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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KIF3C-ADCY3 (FusionGDB2 ID:HG3797TG109)

Fusion Gene Summary for KIF3C-ADCY3

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF3C-ADCY3
Fusion gene ID: hg3797tg109
HgeneTgene
Gene symbol

KIF3C

ADCY3

Gene ID

3797

109

Gene namekinesin family member 3Cadenylate cyclase 3
Synonyms-AC-III|AC3|BMIQ19
Cytomap('KIF3C')('ADCY3')

2p23.3

2p23.3

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF3CKIF3C variant proteinadenylate cyclase type 3ATP pyrophosphate-lyase 3adenylate cyclase type IIIadenylate cyclase, olfactive typeadenylyl cyclase 3adenylyl cyclase, type III
Modification date2020031320200313
UniProtAcc

O14782

.
Ensembl transtripts involved in fusion geneENST00000264712, ENST00000405914, 
ENST00000496378, 
Fusion gene scores* DoF score7 X 5 X 4=1403 X 3 X 3=27
# samples 94
** MAII scorelog2(9/140*10)=-0.637429920615292
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KIF3C [Title/Abstract] AND ADCY3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKIF3C(26203242)-ADCY3(25095588), # samples:3
Anticipated loss of major functional domain due to fusion event.KIF3C-ADCY3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KIF3C-ADCY3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KIF3C-ADCY3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KIF3C-ADCY3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KIF3C-ADCY3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KIF3C-ADCY3 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
KIF3C-ADCY3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across KIF3C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ADCY3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-59-A5PD-01AKIF3Cchr2

26203242

-ADCY3chr2

25095588

-
ChimerDB4OVTCGA-59-A5PDKIF3Cchr2

26203241

-ADCY3chr2

25095588

-


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Fusion Gene ORF analysis for KIF3C-ADCY3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000264712ENST00000405392KIF3Cchr2

26203242

-ADCY3chr2

25095588

-
5CDS-intronENST00000264712ENST00000405392KIF3Cchr2

26203241

-ADCY3chr2

25095588

-
5CDS-intronENST00000264712ENST00000450524KIF3Cchr2

26203242

-ADCY3chr2

25095588

-
5CDS-intronENST00000264712ENST00000450524KIF3Cchr2

26203241

-ADCY3chr2

25095588

-
5CDS-intronENST00000405914ENST00000405392KIF3Cchr2

26203242

-ADCY3chr2

25095588

-
5CDS-intronENST00000405914ENST00000405392KIF3Cchr2

26203241

-ADCY3chr2

25095588

-
5CDS-intronENST00000405914ENST00000450524KIF3Cchr2

26203242

-ADCY3chr2

25095588

-
5CDS-intronENST00000405914ENST00000450524KIF3Cchr2

26203241

-ADCY3chr2

25095588

-
Frame-shiftENST00000405914ENST00000260600KIF3Cchr2

26203242

-ADCY3chr2

25095588

-
Frame-shiftENST00000405914ENST00000260600KIF3Cchr2

26203241

-ADCY3chr2

25095588

-
In-frameENST00000264712ENST00000260600KIF3Cchr2

26203242

-ADCY3chr2

25095588

-
In-frameENST00000264712ENST00000260600KIF3Cchr2

26203241

-ADCY3chr2

25095588

-
intron-3CDSENST00000496378ENST00000260600KIF3Cchr2

26203242

-ADCY3chr2

25095588

-
intron-3CDSENST00000496378ENST00000260600KIF3Cchr2

26203241

-ADCY3chr2

25095588

-
intron-intronENST00000496378ENST00000405392KIF3Cchr2

26203242

-ADCY3chr2

25095588

-
intron-intronENST00000496378ENST00000405392KIF3Cchr2

26203241

-ADCY3chr2

25095588

-
intron-intronENST00000496378ENST00000450524KIF3Cchr2

26203242

-ADCY3chr2

25095588

-
intron-intronENST00000496378ENST00000450524KIF3Cchr2

26203241

-ADCY3chr2

25095588

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264712KIF3Cchr226203242-ENST00000260600ADCY3chr225095588-5648212558048841434
ENST00000264712KIF3Cchr226203241-ENST00000260600ADCY3chr225095588-5648212558048841434

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264712ENST00000260600KIF3Cchr226203242-ADCY3chr225095588-0.0078151930.9921848
ENST00000264712ENST00000260600KIF3Cchr226203241-ADCY3chr225095588-0.0078151930.9921848

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Fusion Genomic Features for KIF3C-ADCY3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for KIF3C-ADCY3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:26203242/chr2:25095588)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF3C

O14782

.
FUNCTION: Microtubule-based anterograde translocator for membranous organelles. {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIF3Cchr2:26203241chr2:25095588ENST00000264712-18270_284515794.0Compositional biasNote=Poly-Gly
HgeneKIF3Cchr2:26203241chr2:25095588ENST00000264712-18438_441515794.0Compositional biasNote=Poly-Asn
HgeneKIF3Cchr2:26203241chr2:25095588ENST00000405914-29270_284515794.0Compositional biasNote=Poly-Gly
HgeneKIF3Cchr2:26203241chr2:25095588ENST00000405914-29438_441515794.0Compositional biasNote=Poly-Asn
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000264712-18270_284515794.0Compositional biasNote=Poly-Gly
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000264712-18438_441515794.0Compositional biasNote=Poly-Asn
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000405914-29270_284515794.0Compositional biasNote=Poly-Gly
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000405914-29438_441515794.0Compositional biasNote=Poly-Asn
HgeneKIF3Cchr2:26203241chr2:25095588ENST00000264712-1810_365515794.0DomainKinesin motor
HgeneKIF3Cchr2:26203241chr2:25095588ENST00000405914-2910_365515794.0DomainKinesin motor
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000264712-1810_365515794.0DomainKinesin motor
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000405914-2910_365515794.0DomainKinesin motor
HgeneKIF3Cchr2:26203241chr2:25095588ENST00000264712-1897_104515794.0Nucleotide bindingNote=ATP
HgeneKIF3Cchr2:26203241chr2:25095588ENST00000405914-2997_104515794.0Nucleotide bindingNote=ATP
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000264712-1897_104515794.0Nucleotide bindingNote=ATP
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000405914-2997_104515794.0Nucleotide bindingNote=ATP
TgeneADCY3chr2:26203241chr2:25095588ENST000002606000211062_10642251145.0Nucleotide bindingATP
TgeneADCY3chr2:26203241chr2:25095588ENST000002606000211069_10732251145.0Nucleotide bindingATP
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021324_3292251145.0Nucleotide bindingATP
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021366_3682251145.0Nucleotide bindingATP
TgeneADCY3chr2:26203242chr2:25095588ENST000002606000211062_10642251145.0Nucleotide bindingATP
TgeneADCY3chr2:26203242chr2:25095588ENST000002606000211069_10732251145.0Nucleotide bindingATP
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021324_3292251145.0Nucleotide bindingATP
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021366_3682251145.0Nucleotide bindingATP
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021402_6322251145.0Topological domainCytoplasmic
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021854_11442251145.0Topological domainCytoplasmic
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021402_6322251145.0Topological domainCytoplasmic
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021854_11442251145.0Topological domainCytoplasmic
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021226_2462251145.0TransmembraneHelical
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021381_4012251145.0TransmembraneHelical
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021633_6532251145.0TransmembraneHelical
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021664_6842251145.0TransmembraneHelical
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021708_7282251145.0TransmembraneHelical
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021754_7742251145.0TransmembraneHelical
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021775_7952251145.0TransmembraneHelical
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021833_8532251145.0TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021226_2462251145.0TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021381_4012251145.0TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021633_6532251145.0TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021664_6842251145.0TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021708_7282251145.0TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021754_7742251145.0TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021775_7952251145.0TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021833_8532251145.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIF3Cchr2:26203241chr2:25095588ENST00000264712-18376_629515794.0Coiled coilOntology_term=ECO:0000255
HgeneKIF3Cchr2:26203241chr2:25095588ENST00000405914-29376_629515794.0Coiled coilOntology_term=ECO:0000255
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000264712-18376_629515794.0Coiled coilOntology_term=ECO:0000255
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000405914-29376_629515794.0Coiled coilOntology_term=ECO:0000255
HgeneKIF3Cchr2:26203241chr2:25095588ENST00000264712-18630_793515794.0RegionGlobular
HgeneKIF3Cchr2:26203241chr2:25095588ENST00000405914-29630_793515794.0RegionGlobular
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000264712-18630_793515794.0RegionGlobular
HgeneKIF3Cchr2:26203242chr2:25095588ENST00000405914-29630_793515794.0RegionGlobular
TgeneADCY3chr2:26203241chr2:25095588ENST000002606000211_792251145.0Topological domainCytoplasmic
TgeneADCY3chr2:26203242chr2:25095588ENST000002606000211_792251145.0Topological domainCytoplasmic
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021105_1252251145.0TransmembraneHelical
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021139_1592251145.0TransmembraneHelical
TgeneADCY3chr2:26203241chr2:25095588ENST00000260600021173_1932251145.0TransmembraneHelical
TgeneADCY3chr2:26203241chr2:25095588ENST0000026060002180_1002251145.0TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021105_1252251145.0TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021139_1592251145.0TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST00000260600021173_1932251145.0TransmembraneHelical
TgeneADCY3chr2:26203242chr2:25095588ENST0000026060002180_1002251145.0TransmembraneHelical


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Fusion Gene Sequence for KIF3C-ADCY3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>42706_42706_1_KIF3C-ADCY3_KIF3C_chr2_26203241_ENST00000264712_ADCY3_chr2_25095588_ENST00000260600_length(transcript)=5648nt_BP=2125nt
GTTTTTCTCTCTCATTCTCCAGTGGCGGCGGCGGGGAAGGCGGAGGCAGAGGCAGCAGCAGCCGCGCTGGCTGCAATGAATGATCCCCCA
GCTTGGGGGGAGGACTCCAGGTGAGCCTCTGCCCTCGGGAGGCCCGGGACCCCCGGCCGCCCACGACCGGCAGCCCACGCTATGGATCCC
TAGAGGAAGGAGGAGAAGACAGCTCGCCGCCCACCCCCATCCCATTTTCCTCTTCCTTTATCTCATTGTTGCCGAAGCTGTTTACGGCAG
CGCTCCCTCTGCTCCTGCATGGGGCGGGCTCCGGGCACGGCTGCTCGGCAGGCGCTGCTCCCGCGGCGACTGGGGGATTCTGCCTAATTC
ACCTCCCAGCCGGTGCAGAGAGGACCGGAGAGCGGTGGAGGCCCGGACTGCAGCAGCGTTGGGGCCACCTCCCAGCGTCCCCACCCTAGG
AGGCTGCATGCGGATTGAAGAGCTGCGCCTGGGGGCTGGGCCGGCCCCGCTGATCCCGACCTAGCGAGCAGGATAGCAGGACCGCCCAGG
CTGCGGAGGGGCTCGGGGGCAGGAAGGTCAGAGCAGCAAGATGGCCAGTAAGACCAAGGCCAGCGAGGCCCTCAAGGTGGTGGCCCGGTG
CCGCCCCCTCAGCAGGAAGGAGGAGGCTGCTGGTCACGAGCAGATCCTGACCATGGACGTGAAACTGGGCCAGGTGACCCTGCGGAACCC
CCGCGCCGCCCCGGGGGAGCTGCCCAAGACCTTCACCTTTGACGCCGTGTATGATGCCAGCTCCAAGCAGGCCGACCTGTATGACGAAAC
CGTGAGGCCCCTGATAGACTCCGTGCTCCAGGGTTTCAATGGCACGGTGTTTGCCTATGGCCAGACGGGCACTGGCAAGACCTATACCAT
GCAGGGGACCTGGGTGGAGCCCGAGCTGCGCGGGGTCATCCCGAATGCCTTTGAGCACATCTTCACCCACATCTCCCGCTCCCAGAACCA
ACAGTACCTGGTCCGGGCCTCCTATTTGGAGATCTACCAGGAAGAGATTCGAGACCTGCTCTCCAAGGAGCCGGGCAAGAGGCTAGAGCT
GAAAGAGAACCCCGAGACTGGCGTCTACATCAAGGACCTCTCCTCCTTCGTCACCAAGAATGTCAAGGAGATTGAGCATGTGATGAACCT
GGGGAACCAGACCCGGGCTGTGGGCAGCACCCACATGAATGAGGTCAGCTCCCGCTCCCATGCCATCTTCATCATCACTGTGGAGTGCAG
CGAACGTGGCTCTGATGGCCAGGACCACATCCGAGTGGGCAAGCTCAACCTCGTGGACCTGGCTGGCAGCGAGAGGCAGAACAAGGCAGG
CCCCAACACAGCGGGAGGGGCAGCCACACCATCCTCGGGTGGCGGTGGTGGCGGTGGAGGCAGTGGTGGTGGTGCTGGTGGAGAGAGGCC
TAAGGAAGCCTCCAAAATCAACCTCTCATTATCTGCCCTGGGCAACGTGATTGCTGCCCTGGCGGGCAACAGGAGCACCCACATTCCCTA
CCGGGACTCCAAGCTGACCCGGCTGCTCCAGGACTCCCTGGGGGGGAATGCCAAGACCATCATGGTAGCCACACTGGGGCCAGCTTCTCA
CAGCTACGATGAGAGCCTCTCCACCTTGCGCTTTGCCAACCGAGCCAAGAACATCAAGAACAAGCCCCAGGTGAACGAGGACCCCAAGGA
CACACTGCTGCGGGAATTCCAAGAGGAGATTGCCCGCCTGAAGGCCCAGCTGGAGAAGAGGGGGATGCTGGGGAAGCGGCCCCGGAGGAA
GAGCAGCCGCAGGAAGAAGGCCGTGTCCGCCCCGCCTGGGTACCCTGAGGGCCCAGTGATTGAGGCCTGGGTGGCAGAAGAGGAGGATGA
CAACAACAACAACCACCGCCCGCCCCAGCCCATCCTGGAGTCAGCCTTGGAGAAGAACATGGAGAATTACCTGCAGGAACAGAAGGAGCG
GCTGGAGGAGGAGAAGGCAGCCATCCAGGATGACCGCAGCCTGGTGAGCGAGGAGAAGCAGAAGCTGCTGGAGGAGAAGGAGAAGATGCT
GGAGGACCTGCGGCGGGAACAGCAGGCCACAGAGCTGCTTGCGGCCAAGTACAAGATCCTGGCCAACGTCTTCCTCTACCTGTGCGCCAT
CGCTGTGGGCATCATGTCCTACTACATGGCTGACCGCAAGCACCGCAAGGCCTTCCTGGAGGCCCGCCAGTCGCTGGAGGTGAAGATGAA
CCTGGAAGAGCAGAGCCAGCAGCAGGAGAACCTCATGCTTTCCATCCTGCCCAAGCACGTGGCTGACGAGATGCTGAAAGACATGAAGAA
AGACGAGAGCCAGAAGGACCAGCAGCAGTTCAACACCATGTACATGTACCGTCACGAGAACGTCAGCATCCTCTTTGCCGACATCGTGGG
CTTTACCCAGCTGTCTTCTGCCTGCAGTGCCCAGGAGCTTGTGAAGCTGCTCAACGAGCTCTTTGCCCGCTTTGACAAGCTGGCAGCTAA
ATACCACCAGCTGCGGATTAAGATCCTGGGCGACTGCTACTACTGCATCTGCGGCTTGCCCGACTACCGGGAGGACCACGCCGTCTGCTC
CATCCTCATGGGGCTGGCCATGGTGGAGGCCATCTCGTATGTGCGGGAGAAGACCAAGACTGGGGTGGACATGCGTGTGGGGGTGCACAC
GGGCACCGTGCTGGGGGGCGTCCTGGGCCAGAAGCGCTGGCAGTACGACGTGTGGTCGACTGATGTCACTGTAGCCAACAAGATGGAGGC
CGGCGGCATCCCTGGGCGCGTGCACATCTCCCAGAGCACCATGGACTGCCTGAAAGGGGAGTTTGATGTGGAGCCAGGCGATGGGGGCAG
CCGCTGTGATTACCTAGAAGAGAAGGGTATTGAAACCTACCTCATCATTGCCTCCAAGCCAGAGGTGAAGAAAACAGCCACCCAGAATGG
CCTCAATGGCTCGGCCCTGCCCAATGGAGCACCAGCTTCCTCAAAGTCCAGCTCCCCTGCCCTCATTGAGACCAAGGAGCCCAACGGGAG
TGCCCACAGCAGTGGGTCCACGTCGGAGAAGCCCGAGGAGCAGGATGCCCAGGCCGACAACCCCTCATTCCCCAACCCACGCCGGAGGCT
GCGCCTGCAGGACCTGGCTGACCGAGTGGTGGATGCCTCTGAAGATGAGCACGAGCTCAACCAGCTGCTCAACGAGGCCCTGCTTGAGCG
AGAGTCCGCCCAAGTAGTAAAGAAGAGAAACACCTTCCTCTTGTCCATGCGGTTCATGGACCCCGAGATGGAAACCCGCTACTCGGTGGA
GAAGGAGAAGCAGAGTGGGGCTGCCTTCAGCTGCTCCTGCGTCGTCCTGCTCTGCACGGCCCTGGTCGAGATACTCATCGACCCCTGGCT
AATGACAAACTATGTGACCTTCATGGTGGGGGAGATTCTGCTCCTCATCCTGACCATCTGCTCCCTGGCTGCCATCTTTCCCCGGGCCTT
TCCTAAGAAGCTTGTGGCCTTCTCAACTTGGATTGACCGGACCCGCTGGGCCAGGAACACCTGGGCCATGCTCGCCATCTTCATCCTGGT
GATGGCAAATGTCGTGGACATGCTCAGCTGTCTCCAGTACTACACGGGACCCAGCAATGCAACGGCAGGGATGGAAACGGAGGGCAGCTG
CCTGGAGAACCCCAAGTATTACAACTATGTGGCCGTGCTGTCCCTCATCGCCACCATCATGCTGGTGCAGGTCAGCCACATGGTGAAGCT
CACGCTCATGCTGCTCGTCGCAGGCGCCGTGGCCACCATCAACCTCTATGCCTGGCGTCCCGTCTTTGATGAATACGACCACAAGCGTTT
TCGGGAGCACGACTTACCTATGGTGGCCTTAGAGCAGATGCAAGGATTCAACCCTGGGCTCAATGGCACTGACAGGCTGCCCCTGGTGCC
TTCCAAGTACTCTATGACGGTGATGGTGTTCCTCATGATGCTCAGCTTCTACTACTTCTCCCGCCACGTAGAAAAACTGGCACGGACACT
TTTCTTGTGGAAGATTGAGGTCCACGACCAGAAGGAACGTGTCTATGAGATGCGACGCTGGAACGAGGCCTTGGTCACCAACATGTTGCC
TGAGCACGTGGCACGCCATTTCCTGGGGTCCAAGAAGAGAGATGAGGAGCTGTATAGCCAGACGTATGATGAGATTGGAGTCATGTTTGC
CTCCCTGCCCAACTTTGCTGACTTCTACACAGAGGAGAGCATCAACAATGGTGGTATTGAGTGTCTGCGTTTCCTCAATGAAATCATCTC
AGATTTTGACTCTCTCCTGGACAATCCCAAGTTCCGGGTGATCACCAAGATCAAAACCATTGGCAGCACGTATATGGCGGCTTCAGGAGT
CACCCCCGATGTCAACACCAATGGCTTTGCCAGCTCCAACAAGGAAGACAAGTCCGAGAGAGAGCGCTGGCAGCACCTGGCTGACCTGGC
CGACTTCGCGCTGGCCATGAAGGATACGCTCACCAACATCAACAACCAGTCCTTCAATAACTTCATGCTGCGCATAGGCATGAACAAAGG
CGGGGTTCTGGCTGGGGTCATCGGAGCCCGGAAACCACACTACGACATCTGGGGCAATACAGTCAATGTAGCCAGCAGGATGGAGTCCAC
GGGGGTCATGGGCAACATTCAGGTGGTAGAAGAAACCCAAGTCATCCTCCGAGAGTACGGCTTCCGCTTTGTGAGGCGAGGCCCCATCTT
TGTGAAGGGGAAGGGGGAGCTGCTGACCTTCTTCTTGAAGGGGCGGGATAAGCTAGCCACCTTCCCCAATGGCCCCTCTGTCACACTGCC
CCACCAGGTGGTGGACAACTCCTGAATGGCCTCGAGCCTGCAACAGTCCAAACCGGAAGGGAGAATTTATTTTTTGAAACTGAAGGAAGT
CCCGACCTTCCTGGATTGAAGTGCACACTCATGGACTTTAGGTTTAGAAACCTCCTCAGCCTTCATTTGTTCGTGGATGTGTGAGCTCTG
AGGGTGGCCCTGCTATTCCTGTGTGTGCCTGTAGTGTCCCCAGCATAGGGGTCTTAGGCATAGGGCTGAACAGTCCTTCCAGAGCCCTCG
TTCCAATCCCTGCCGTCCTTGCCCCTGAGGGGCCCTGACCACTGTGAGCAGGAGGGTGGCAGAGCTGGGACAAAGCTGCCTTTGCCGCTG
GGCTTTCCGGGACTGTGGAGGGAGCACAGGCGGGGAAGCTCCACTTCAGACAGGGCTTGGTGGGGCAGGACATGGCTCCCATTTTGAAGG
GAGGTCTCCATGTGGTCCGAGTGAGGTGAGACGGCCCTCGTCCTGGTGTTCCTGATCATCTTGAAAGGTTCTTCTGGAACTCCTGTCCCC
TTAGTCATGAGAACAGAAAGTGCAATATTTCCTTTCACCTGGCAGGGGAGGGGGGATTTATTTCTGAAAGAAAAATATATAAACAGATCT
TCTACATTTATATTTTTAATCTTCTGTTAAATACACTTTCCGATATTGCCTTGCCTTTTGAGCTCTTGCTACAGTCGCCTTTGCTACTGC

>42706_42706_1_KIF3C-ADCY3_KIF3C_chr2_26203241_ENST00000264712_ADCY3_chr2_25095588_ENST00000260600_length(amino acids)=1434AA_BP=0
MASKTKASEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYDASSKQADLYDETVRPLIDSVLQGFN
GTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDL
SSFVTKNVKEIEHVMNLGNQTRAVGSTHMNEVSSRSHAIFIITVECSERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNTAGGAATPSSG
GGGGGGGSGGGAGGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDSKLTRLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFAN
RAKNIKNKPQVNEDPKDTLLREFQEEIARLKAQLEKRGMLGKRPRRKSSRRKKAVSAPPGYPEGPVIEAWVAEEEDDNNNNHRPPQPILE
SALEKNMENYLQEQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLRREQQATELLAAKYKILANVFLYLCAIAVGIMSYYMADRK
HRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQEL
VKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRW
QYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPAS
SKSSSPALIETKEPNGSAHSSGSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFL
LSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDR
TRWARNTWAMLAIFILVMANVVDMLSCLQYYTGPSNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATI
NLYAWRPVFDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKER
VYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRV
ITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPH

--------------------------------------------------------------
>42706_42706_2_KIF3C-ADCY3_KIF3C_chr2_26203242_ENST00000264712_ADCY3_chr2_25095588_ENST00000260600_length(transcript)=5648nt_BP=2125nt
GTTTTTCTCTCTCATTCTCCAGTGGCGGCGGCGGGGAAGGCGGAGGCAGAGGCAGCAGCAGCCGCGCTGGCTGCAATGAATGATCCCCCA
GCTTGGGGGGAGGACTCCAGGTGAGCCTCTGCCCTCGGGAGGCCCGGGACCCCCGGCCGCCCACGACCGGCAGCCCACGCTATGGATCCC
TAGAGGAAGGAGGAGAAGACAGCTCGCCGCCCACCCCCATCCCATTTTCCTCTTCCTTTATCTCATTGTTGCCGAAGCTGTTTACGGCAG
CGCTCCCTCTGCTCCTGCATGGGGCGGGCTCCGGGCACGGCTGCTCGGCAGGCGCTGCTCCCGCGGCGACTGGGGGATTCTGCCTAATTC
ACCTCCCAGCCGGTGCAGAGAGGACCGGAGAGCGGTGGAGGCCCGGACTGCAGCAGCGTTGGGGCCACCTCCCAGCGTCCCCACCCTAGG
AGGCTGCATGCGGATTGAAGAGCTGCGCCTGGGGGCTGGGCCGGCCCCGCTGATCCCGACCTAGCGAGCAGGATAGCAGGACCGCCCAGG
CTGCGGAGGGGCTCGGGGGCAGGAAGGTCAGAGCAGCAAGATGGCCAGTAAGACCAAGGCCAGCGAGGCCCTCAAGGTGGTGGCCCGGTG
CCGCCCCCTCAGCAGGAAGGAGGAGGCTGCTGGTCACGAGCAGATCCTGACCATGGACGTGAAACTGGGCCAGGTGACCCTGCGGAACCC
CCGCGCCGCCCCGGGGGAGCTGCCCAAGACCTTCACCTTTGACGCCGTGTATGATGCCAGCTCCAAGCAGGCCGACCTGTATGACGAAAC
CGTGAGGCCCCTGATAGACTCCGTGCTCCAGGGTTTCAATGGCACGGTGTTTGCCTATGGCCAGACGGGCACTGGCAAGACCTATACCAT
GCAGGGGACCTGGGTGGAGCCCGAGCTGCGCGGGGTCATCCCGAATGCCTTTGAGCACATCTTCACCCACATCTCCCGCTCCCAGAACCA
ACAGTACCTGGTCCGGGCCTCCTATTTGGAGATCTACCAGGAAGAGATTCGAGACCTGCTCTCCAAGGAGCCGGGCAAGAGGCTAGAGCT
GAAAGAGAACCCCGAGACTGGCGTCTACATCAAGGACCTCTCCTCCTTCGTCACCAAGAATGTCAAGGAGATTGAGCATGTGATGAACCT
GGGGAACCAGACCCGGGCTGTGGGCAGCACCCACATGAATGAGGTCAGCTCCCGCTCCCATGCCATCTTCATCATCACTGTGGAGTGCAG
CGAACGTGGCTCTGATGGCCAGGACCACATCCGAGTGGGCAAGCTCAACCTCGTGGACCTGGCTGGCAGCGAGAGGCAGAACAAGGCAGG
CCCCAACACAGCGGGAGGGGCAGCCACACCATCCTCGGGTGGCGGTGGTGGCGGTGGAGGCAGTGGTGGTGGTGCTGGTGGAGAGAGGCC
TAAGGAAGCCTCCAAAATCAACCTCTCATTATCTGCCCTGGGCAACGTGATTGCTGCCCTGGCGGGCAACAGGAGCACCCACATTCCCTA
CCGGGACTCCAAGCTGACCCGGCTGCTCCAGGACTCCCTGGGGGGGAATGCCAAGACCATCATGGTAGCCACACTGGGGCCAGCTTCTCA
CAGCTACGATGAGAGCCTCTCCACCTTGCGCTTTGCCAACCGAGCCAAGAACATCAAGAACAAGCCCCAGGTGAACGAGGACCCCAAGGA
CACACTGCTGCGGGAATTCCAAGAGGAGATTGCCCGCCTGAAGGCCCAGCTGGAGAAGAGGGGGATGCTGGGGAAGCGGCCCCGGAGGAA
GAGCAGCCGCAGGAAGAAGGCCGTGTCCGCCCCGCCTGGGTACCCTGAGGGCCCAGTGATTGAGGCCTGGGTGGCAGAAGAGGAGGATGA
CAACAACAACAACCACCGCCCGCCCCAGCCCATCCTGGAGTCAGCCTTGGAGAAGAACATGGAGAATTACCTGCAGGAACAGAAGGAGCG
GCTGGAGGAGGAGAAGGCAGCCATCCAGGATGACCGCAGCCTGGTGAGCGAGGAGAAGCAGAAGCTGCTGGAGGAGAAGGAGAAGATGCT
GGAGGACCTGCGGCGGGAACAGCAGGCCACAGAGCTGCTTGCGGCCAAGTACAAGATCCTGGCCAACGTCTTCCTCTACCTGTGCGCCAT
CGCTGTGGGCATCATGTCCTACTACATGGCTGACCGCAAGCACCGCAAGGCCTTCCTGGAGGCCCGCCAGTCGCTGGAGGTGAAGATGAA
CCTGGAAGAGCAGAGCCAGCAGCAGGAGAACCTCATGCTTTCCATCCTGCCCAAGCACGTGGCTGACGAGATGCTGAAAGACATGAAGAA
AGACGAGAGCCAGAAGGACCAGCAGCAGTTCAACACCATGTACATGTACCGTCACGAGAACGTCAGCATCCTCTTTGCCGACATCGTGGG
CTTTACCCAGCTGTCTTCTGCCTGCAGTGCCCAGGAGCTTGTGAAGCTGCTCAACGAGCTCTTTGCCCGCTTTGACAAGCTGGCAGCTAA
ATACCACCAGCTGCGGATTAAGATCCTGGGCGACTGCTACTACTGCATCTGCGGCTTGCCCGACTACCGGGAGGACCACGCCGTCTGCTC
CATCCTCATGGGGCTGGCCATGGTGGAGGCCATCTCGTATGTGCGGGAGAAGACCAAGACTGGGGTGGACATGCGTGTGGGGGTGCACAC
GGGCACCGTGCTGGGGGGCGTCCTGGGCCAGAAGCGCTGGCAGTACGACGTGTGGTCGACTGATGTCACTGTAGCCAACAAGATGGAGGC
CGGCGGCATCCCTGGGCGCGTGCACATCTCCCAGAGCACCATGGACTGCCTGAAAGGGGAGTTTGATGTGGAGCCAGGCGATGGGGGCAG
CCGCTGTGATTACCTAGAAGAGAAGGGTATTGAAACCTACCTCATCATTGCCTCCAAGCCAGAGGTGAAGAAAACAGCCACCCAGAATGG
CCTCAATGGCTCGGCCCTGCCCAATGGAGCACCAGCTTCCTCAAAGTCCAGCTCCCCTGCCCTCATTGAGACCAAGGAGCCCAACGGGAG
TGCCCACAGCAGTGGGTCCACGTCGGAGAAGCCCGAGGAGCAGGATGCCCAGGCCGACAACCCCTCATTCCCCAACCCACGCCGGAGGCT
GCGCCTGCAGGACCTGGCTGACCGAGTGGTGGATGCCTCTGAAGATGAGCACGAGCTCAACCAGCTGCTCAACGAGGCCCTGCTTGAGCG
AGAGTCCGCCCAAGTAGTAAAGAAGAGAAACACCTTCCTCTTGTCCATGCGGTTCATGGACCCCGAGATGGAAACCCGCTACTCGGTGGA
GAAGGAGAAGCAGAGTGGGGCTGCCTTCAGCTGCTCCTGCGTCGTCCTGCTCTGCACGGCCCTGGTCGAGATACTCATCGACCCCTGGCT
AATGACAAACTATGTGACCTTCATGGTGGGGGAGATTCTGCTCCTCATCCTGACCATCTGCTCCCTGGCTGCCATCTTTCCCCGGGCCTT
TCCTAAGAAGCTTGTGGCCTTCTCAACTTGGATTGACCGGACCCGCTGGGCCAGGAACACCTGGGCCATGCTCGCCATCTTCATCCTGGT
GATGGCAAATGTCGTGGACATGCTCAGCTGTCTCCAGTACTACACGGGACCCAGCAATGCAACGGCAGGGATGGAAACGGAGGGCAGCTG
CCTGGAGAACCCCAAGTATTACAACTATGTGGCCGTGCTGTCCCTCATCGCCACCATCATGCTGGTGCAGGTCAGCCACATGGTGAAGCT
CACGCTCATGCTGCTCGTCGCAGGCGCCGTGGCCACCATCAACCTCTATGCCTGGCGTCCCGTCTTTGATGAATACGACCACAAGCGTTT
TCGGGAGCACGACTTACCTATGGTGGCCTTAGAGCAGATGCAAGGATTCAACCCTGGGCTCAATGGCACTGACAGGCTGCCCCTGGTGCC
TTCCAAGTACTCTATGACGGTGATGGTGTTCCTCATGATGCTCAGCTTCTACTACTTCTCCCGCCACGTAGAAAAACTGGCACGGACACT
TTTCTTGTGGAAGATTGAGGTCCACGACCAGAAGGAACGTGTCTATGAGATGCGACGCTGGAACGAGGCCTTGGTCACCAACATGTTGCC
TGAGCACGTGGCACGCCATTTCCTGGGGTCCAAGAAGAGAGATGAGGAGCTGTATAGCCAGACGTATGATGAGATTGGAGTCATGTTTGC
CTCCCTGCCCAACTTTGCTGACTTCTACACAGAGGAGAGCATCAACAATGGTGGTATTGAGTGTCTGCGTTTCCTCAATGAAATCATCTC
AGATTTTGACTCTCTCCTGGACAATCCCAAGTTCCGGGTGATCACCAAGATCAAAACCATTGGCAGCACGTATATGGCGGCTTCAGGAGT
CACCCCCGATGTCAACACCAATGGCTTTGCCAGCTCCAACAAGGAAGACAAGTCCGAGAGAGAGCGCTGGCAGCACCTGGCTGACCTGGC
CGACTTCGCGCTGGCCATGAAGGATACGCTCACCAACATCAACAACCAGTCCTTCAATAACTTCATGCTGCGCATAGGCATGAACAAAGG
CGGGGTTCTGGCTGGGGTCATCGGAGCCCGGAAACCACACTACGACATCTGGGGCAATACAGTCAATGTAGCCAGCAGGATGGAGTCCAC
GGGGGTCATGGGCAACATTCAGGTGGTAGAAGAAACCCAAGTCATCCTCCGAGAGTACGGCTTCCGCTTTGTGAGGCGAGGCCCCATCTT
TGTGAAGGGGAAGGGGGAGCTGCTGACCTTCTTCTTGAAGGGGCGGGATAAGCTAGCCACCTTCCCCAATGGCCCCTCTGTCACACTGCC
CCACCAGGTGGTGGACAACTCCTGAATGGCCTCGAGCCTGCAACAGTCCAAACCGGAAGGGAGAATTTATTTTTTGAAACTGAAGGAAGT
CCCGACCTTCCTGGATTGAAGTGCACACTCATGGACTTTAGGTTTAGAAACCTCCTCAGCCTTCATTTGTTCGTGGATGTGTGAGCTCTG
AGGGTGGCCCTGCTATTCCTGTGTGTGCCTGTAGTGTCCCCAGCATAGGGGTCTTAGGCATAGGGCTGAACAGTCCTTCCAGAGCCCTCG
TTCCAATCCCTGCCGTCCTTGCCCCTGAGGGGCCCTGACCACTGTGAGCAGGAGGGTGGCAGAGCTGGGACAAAGCTGCCTTTGCCGCTG
GGCTTTCCGGGACTGTGGAGGGAGCACAGGCGGGGAAGCTCCACTTCAGACAGGGCTTGGTGGGGCAGGACATGGCTCCCATTTTGAAGG
GAGGTCTCCATGTGGTCCGAGTGAGGTGAGACGGCCCTCGTCCTGGTGTTCCTGATCATCTTGAAAGGTTCTTCTGGAACTCCTGTCCCC
TTAGTCATGAGAACAGAAAGTGCAATATTTCCTTTCACCTGGCAGGGGAGGGGGGATTTATTTCTGAAAGAAAAATATATAAACAGATCT
TCTACATTTATATTTTTAATCTTCTGTTAAATACACTTTCCGATATTGCCTTGCCTTTTGAGCTCTTGCTACAGTCGCCTTTGCTACTGC

>42706_42706_2_KIF3C-ADCY3_KIF3C_chr2_26203242_ENST00000264712_ADCY3_chr2_25095588_ENST00000260600_length(amino acids)=1434AA_BP=0
MASKTKASEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYDASSKQADLYDETVRPLIDSVLQGFN
GTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDL
SSFVTKNVKEIEHVMNLGNQTRAVGSTHMNEVSSRSHAIFIITVECSERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNTAGGAATPSSG
GGGGGGGSGGGAGGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDSKLTRLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFAN
RAKNIKNKPQVNEDPKDTLLREFQEEIARLKAQLEKRGMLGKRPRRKSSRRKKAVSAPPGYPEGPVIEAWVAEEEDDNNNNHRPPQPILE
SALEKNMENYLQEQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLRREQQATELLAAKYKILANVFLYLCAIAVGIMSYYMADRK
HRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQEL
VKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRW
QYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPAS
SKSSSPALIETKEPNGSAHSSGSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFL
LSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDR
TRWARNTWAMLAIFILVMANVVDMLSCLQYYTGPSNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATI
NLYAWRPVFDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKER
VYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRV
ITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KIF3C-ADCY3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KIF3C-ADCY3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KIF3C-ADCY3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKIF3CC0004238Atrial Fibrillation2CTD_human
HgeneKIF3CC0235480Paroxysmal atrial fibrillation2CTD_human
HgeneKIF3CC2585653Persistent atrial fibrillation2CTD_human
HgeneKIF3CC3468561familial atrial fibrillation2CTD_human
HgeneKIF3CC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
HgeneKIF3CC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
HgeneKIF3CC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human
TgeneC0005586Bipolar Disorder1PSYGENET
TgeneC0011875Diabetic Angiopathies1CTD_human
TgeneC0025945Microangiopathy, Diabetic1CTD_human
TgeneC0028754Obesity1CTD_human
TgeneC0028756Obesity, Morbid1CTD_human
TgeneC0525045Mood Disorders1PSYGENET