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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMEM189-MMP23B (FusionGDB2 ID:HG387521TG8510)

Fusion Gene Summary for TMEM189-MMP23B

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM189-MMP23B
Fusion gene ID: hg387521tg8510
HgeneTgene
Gene symbol

TMEM189

MMP23B

Gene ID

387521

8510

Gene nametransmembrane protein 189matrix metallopeptidase 23B
SynonymsCarF|KUAMIFR|MIFR-1|MMP22|MMP23A
Cytomap('TMEM189')('MMP23B')

20q13.13

1p36.33

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 189matrix metalloproteinase-23MMP-21MMP-22MMP-23femalysinmatrix metalloproteinase 22matrix metalloproteinase 23Bmatrix metalloproteinase in the female reproductive tractmatrix metalloproteinase-21
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000371650, ENST00000371652, 
ENST00000371656, ENST00000557021, 
Fusion gene scores* DoF score7 X 9 X 6=3781 X 1 X 1=1
# samples 81
** MAII scorelog2(8/378*10)=-2.24031432933371
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: TMEM189 [Title/Abstract] AND MMP23B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMEM189(48744511)-MMP23B(1568566), # samples:1
Anticipated loss of major functional domain due to fusion event.TMEM189-MMP23B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TMEM189-MMP23B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TMEM189-MMP23B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TMEM189-MMP23B seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMEM189

GO:0008611

ether lipid biosynthetic process

31604315

TgeneMMP23B

GO:0006508

proteolysis

9988691


check buttonFusion gene breakpoints across TMEM189 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MMP23B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-L5-A4OQ-11ATMEM189chr20

48744511

-MMP23Bchr1

1568566

+


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Fusion Gene ORF analysis for TMEM189-MMP23B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000371650ENST00000378675TMEM189chr20

48744511

-MMP23Bchr1

1568566

+
Frame-shiftENST00000371652ENST00000378675TMEM189chr20

48744511

-MMP23Bchr1

1568566

+
Frame-shiftENST00000371656ENST00000378675TMEM189chr20

48744511

-MMP23Bchr1

1568566

+
Frame-shiftENST00000557021ENST00000378675TMEM189chr20

48744511

-MMP23Bchr1

1568566

+
In-frameENST00000371650ENST00000356026TMEM189chr20

48744511

-MMP23Bchr1

1568566

+
In-frameENST00000371652ENST00000356026TMEM189chr20

48744511

-MMP23Bchr1

1568566

+
In-frameENST00000371656ENST00000356026TMEM189chr20

48744511

-MMP23Bchr1

1568566

+
In-frameENST00000557021ENST00000356026TMEM189chr20

48744511

-MMP23Bchr1

1568566

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000557021TMEM189chr2048744511-ENST00000356026MMP23Bchr11568566+16278521101597495
ENST00000371650TMEM189chr2048744511-ENST00000356026MMP23Bchr11568566+1554779461524492
ENST00000371652TMEM189chr2048744511-ENST00000356026MMP23Bchr11568566+1563788461533495
ENST00000371656TMEM189chr2048744511-ENST00000356026MMP23Bchr11568566+1338563971308403

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000557021ENST00000356026TMEM189chr2048744511-MMP23Bchr11568566+0.144553070.855447
ENST00000371650ENST00000356026TMEM189chr2048744511-MMP23Bchr11568566+0.172118680.8278813
ENST00000371652ENST00000356026TMEM189chr2048744511-MMP23Bchr11568566+0.146981090.85301894
ENST00000371656ENST00000356026TMEM189chr2048744511-MMP23Bchr11568566+0.149116490.85088354

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Fusion Genomic Features for TMEM189-MMP23B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TMEM189chr2048744511-MMP23Bchr11568566+0.91660140.08339861
TMEM189chr2048744511-MMP23Bchr11568566+0.91660140.08339861

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TMEM189-MMP23B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:48744511/chr1:1568566)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM189chr20:48744511chr1:1568566ENST00000371652-56186_190230271.0MotifHistidine box-1
HgeneTMEM189chr20:48744511chr1:1568566ENST00000371652-56213_217230271.0MotifHistidine box-2
HgeneTMEM189chr20:48744511chr1:1568566ENST00000371652-56161_181230271.0TransmembraneHelical
HgeneTMEM189chr20:48744511chr1:1568566ENST00000371652-5647_67230271.0TransmembraneHelical
HgeneTMEM189chr20:48744511chr1:1568566ENST00000371652-5674_94230271.0TransmembraneHelical
TgeneMMP23Bchr20:48744511chr1:1568566ENST0000035602628295_380142391.0DomainNote=Ig-like C2-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMMP23Bchr20:48744511chr1:1568566ENST00000356026281_19142391.0Topological domainCytoplasmic
TgeneMMP23Bchr20:48744511chr1:1568566ENST000003560262841_390142391.0Topological domainLumenal
TgeneMMP23Bchr20:48744511chr1:1568566ENST000003560262820_40142391.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for TMEM189-MMP23B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>91847_91847_1_TMEM189-MMP23B_TMEM189_chr20_48744511_ENST00000371650_MMP23B_chr1_1568566_ENST00000356026_length(transcript)=1554nt_BP=779nt
GCTGGGCGGTCATTGGGCGGCGTGATCTCGCCGCGGTTCCGCGGCCCTGCCGCCGCCGCCGCCAGCAGAGCGCACCGGGCCGATCGGGCG
AGTGGCCATGGCGGGCGCCGAGAACTGGCCGGGCCAGCAGCTGGAGCTGGACGAGGACGAGGCGTCTTGTTGCCGCTGGGGCGCGCAGCA
CGCCGGGGCCCGCGAGCTGGCTGCGCTCTACTCGCCAGGCAAGCGCCTCCAGGAGTGGTGCTCTGTGATCCTGTGCTTCAGCCTCATCGC
CCACAACCTGGTCCATCTCCTGCTGCTGGCCCGCTGGGAGGACACACCCCTCGTCATACTCGGTGTTGTTGCAGGGGCTCTCATTGCTGA
CTTCTTGTCTGGCCTGGTACACTGGGGTGCTGACACATGGGGCTCTGTGGAGCTGCCCATTGCTTTCATCCGACCCTTCCGGGAGCACCA
CATTGACCCGACAGCTATCACACGGCACGACTTCATCGAGACCAACGGGGACAACTGCCTGGTGACACTGCTGCCGCTGCTAAACATGGC
CTACAAGTTCCGCACCCACAGCCCTGAAGCCCTGGAGCAGCTATACCCCTGGGAGTGCTTCGTCTTCTGCCTGATCATCTTCGGCACCTT
CACCAACCAGATCCACAAGTGGTCGCACACGTACTTTGGGCTGCCACGCTGGGTCACCCTCCTGCAGGACTGGCATGTCATCCTGCCACG
TAAACACCATCGCATCCACCACGTCTCACCCCACGAGACCTACTTCTGCATCACCACAGGCTTCTACCCGATCAACCACACGGACTGCCT
GGTCTCCGCGCTGCACCACTGCTTCGACGGCCCCACGGGGGAGCTGGCCCACGCCTTCTTCCCCCCGCACGGCGGCATCCACTTCGACGA
CAGCGAGTACTGGGTCCTGGGCCCCACGCGCTACAGCTGGAAGAAAGGCGTGTGGCTCACGGACCTGGTGCACGTGGCGGCCCACGAGAT
CGGCCACGCGCTGGGCCTGATGCACTCACAACACGGCCGGGCGCTCATGCACCTGAACGCCACGCTGCGCGGCTGGAAGGCGTTGTCCCA
GGACGAGCTGTGGGGGCTGCACCGGCTCTACGGATGCCTCGACAGGCTGTTCGTGTGCGCGTCCTGGGCGCGGAGGGGCTTCTGCGACGC
TCGCCGGCGGCTCATGAAGAGGCTCTGCCCCAGCAGCTGCGACTTCTGCTACGAATTCCCCTTCCCCACGGTGGCCACCACCCCACCGCC
CCCCAGGACCAAAACCAGGCTGGTGCCCGAGGGCAGGAACGTGACCTTCCGCTGCGGCCAGAAGATCCTCCACAAGAAAGGGAAAGTGTA
CTGGTACAAGGACCAGGAGCCCCTGGAGTTCTCCTACCCCGGCTACCTGGCCCTGGGCGAGGCGCACCTGAGCATCATCGCCAACGCCGT
CAATGAGGGCACCTACACCTGCGTGGTGCGCCGCCAGCAGCGCGTGCTGACCACCTACTCCTGGCGAGTCCGTGTGCGGGGCTGAGCCCG

>91847_91847_1_TMEM189-MMP23B_TMEM189_chr20_48744511_ENST00000371650_MMP23B_chr1_1568566_ENST00000356026_length(amino acids)=492AA_BP=244
MPPPPPAERTGPIGRVAMAGAENWPGQQLELDEDEASCCRWGAQHAGARELAALYSPGKRLQEWCSVILCFSLIAHNLVHLLLLARWEDT
PLVILGVVAGALIADFLSGLVHWGADTWGSVELPIAFIRPFREHHIDPTAITRHDFIETNGDNCLVTLLPLLNMAYKFRTHSPEALEQLY
PWECFVFCLIIFGTFTNQIHKWSHTYFGLPRWVTLLQDWHVILPRKHHRIHHVSPHETYFCITTGFYPINHTDCLVSALHHCFDGPTGEL
AHAFFPPHGGIHFDDSEYWVLGPTRYSWKKGVWLTDLVHVAAHEIGHALGLMHSQHGRALMHLNATLRGWKALSQDELWGLHRLYGCLDR
LFVCASWARRGFCDARRRLMKRLCPSSCDFCYEFPFPTVATTPPPPRTKTRLVPEGRNVTFRCGQKILHKKGKVYWYKDQEPLEFSYPGY

--------------------------------------------------------------
>91847_91847_2_TMEM189-MMP23B_TMEM189_chr20_48744511_ENST00000371652_MMP23B_chr1_1568566_ENST00000356026_length(transcript)=1563nt_BP=788nt
GCTGGGCGGTCATTGGGCGGCGTGATCTCGCCGCGGTTCCGCGGCCCTGCCGCCGCCGCCGCCAGCAGAGCGCACCGGGCCGATCGGGCG
AGTGGCCATGGCGGGCGCCGAGAACTGGCCGGGCCAGCAGCTGGAGCTGGACGAGGACGAGGCGTCTTGTTGCCGCTGGGGCGCGCAGCA
CGCCGGGGCCCGCGAGCTGGCTGCGCTCTACTCGCCAGGCAAGCGCCTCCAGGAGTGGTGCTCTGTGATCCTGTGCTTCAGCCTCATCGC
CCACAACCTGGTCCATCTCCTGCTGCTGGCCCGCTGGGAGGACACACCCCTCGTCATACTCGGTGTTGTTGCAGGGGCTCTCATTGCTGA
CTTCTTGTCTGGCCTGGTACACTGGGGTGCTGACACATGGGGCTCTGTGGAGCTGCCCATTGTGGGGAAGGCTTTCATCCGACCCTTCCG
GGAGCACCACATTGACCCGACAGCTATCACACGGCACGACTTCATCGAGACCAACGGGGACAACTGCCTGGTGACACTGCTGCCGCTGCT
AAACATGGCCTACAAGTTCCGCACCCACAGCCCTGAAGCCCTGGAGCAGCTATACCCCTGGGAGTGCTTCGTCTTCTGCCTGATCATCTT
CGGCACCTTCACCAACCAGATCCACAAGTGGTCGCACACGTACTTTGGGCTGCCACGCTGGGTCACCCTCCTGCAGGACTGGCATGTCAT
CCTGCCACGTAAACACCATCGCATCCACCACGTCTCACCCCACGAGACCTACTTCTGCATCACCACAGGCTTCTACCCGATCAACCACAC
GGACTGCCTGGTCTCCGCGCTGCACCACTGCTTCGACGGCCCCACGGGGGAGCTGGCCCACGCCTTCTTCCCCCCGCACGGCGGCATCCA
CTTCGACGACAGCGAGTACTGGGTCCTGGGCCCCACGCGCTACAGCTGGAAGAAAGGCGTGTGGCTCACGGACCTGGTGCACGTGGCGGC
CCACGAGATCGGCCACGCGCTGGGCCTGATGCACTCACAACACGGCCGGGCGCTCATGCACCTGAACGCCACGCTGCGCGGCTGGAAGGC
GTTGTCCCAGGACGAGCTGTGGGGGCTGCACCGGCTCTACGGATGCCTCGACAGGCTGTTCGTGTGCGCGTCCTGGGCGCGGAGGGGCTT
CTGCGACGCTCGCCGGCGGCTCATGAAGAGGCTCTGCCCCAGCAGCTGCGACTTCTGCTACGAATTCCCCTTCCCCACGGTGGCCACCAC
CCCACCGCCCCCCAGGACCAAAACCAGGCTGGTGCCCGAGGGCAGGAACGTGACCTTCCGCTGCGGCCAGAAGATCCTCCACAAGAAAGG
GAAAGTGTACTGGTACAAGGACCAGGAGCCCCTGGAGTTCTCCTACCCCGGCTACCTGGCCCTGGGCGAGGCGCACCTGAGCATCATCGC
CAACGCCGTCAATGAGGGCACCTACACCTGCGTGGTGCGCCGCCAGCAGCGCGTGCTGACCACCTACTCCTGGCGAGTCCGTGTGCGGGG

>91847_91847_2_TMEM189-MMP23B_TMEM189_chr20_48744511_ENST00000371652_MMP23B_chr1_1568566_ENST00000356026_length(amino acids)=495AA_BP=247
MPPPPPAERTGPIGRVAMAGAENWPGQQLELDEDEASCCRWGAQHAGARELAALYSPGKRLQEWCSVILCFSLIAHNLVHLLLLARWEDT
PLVILGVVAGALIADFLSGLVHWGADTWGSVELPIVGKAFIRPFREHHIDPTAITRHDFIETNGDNCLVTLLPLLNMAYKFRTHSPEALE
QLYPWECFVFCLIIFGTFTNQIHKWSHTYFGLPRWVTLLQDWHVILPRKHHRIHHVSPHETYFCITTGFYPINHTDCLVSALHHCFDGPT
GELAHAFFPPHGGIHFDDSEYWVLGPTRYSWKKGVWLTDLVHVAAHEIGHALGLMHSQHGRALMHLNATLRGWKALSQDELWGLHRLYGC
LDRLFVCASWARRGFCDARRRLMKRLCPSSCDFCYEFPFPTVATTPPPPRTKTRLVPEGRNVTFRCGQKILHKKGKVYWYKDQEPLEFSY

--------------------------------------------------------------
>91847_91847_3_TMEM189-MMP23B_TMEM189_chr20_48744511_ENST00000371656_MMP23B_chr1_1568566_ENST00000356026_length(transcript)=1338nt_BP=563nt
CAAGTAACAGGCAGGAGGAGTGTTAAGCCTGAGGCTCCATCTTCAGGGAAGAAAACATCCCAACTAGAGAAGAAGGGACACCTTCCCCTC
CTAACAAATGAATGAGCGGGCAATTGCAGGGGCTCTCATTGCTGACTTCTTGTCTGGCCTGGTACACTGGGGTGCTGACACATGGGGCTC
TGTGGAGCTGCCCATTGTGGGGAAGGCTTTCATCCGACCCTTCCGGGAGCACCACATTGACCCGACAGCTATCACACGGCACGACTTCAT
CGAGACCAACGGGGACAACTGCCTGGTGACACTGCTGCCGCTGCTAAACATGGCCTACAAGTTCCGCACCCACAGCCCTGAAGCCCTGGA
GCAGCTATACCCCTGGGAGTGCTTCGTCTTCTGCCTGATCATCTTCGGCACCTTCACCAACCAGATCCACAAGTGGTCGCACACGTACTT
TGGGCTGCCACGCTGGGTCACCCTCCTGCAGGACTGGCATGTCATCCTGCCACGTAAACACCATCGCATCCACCACGTCTCACCCCACGA
GACCTACTTCTGCATCACCACAGGCTTCTACCCGATCAACCACACGGACTGCCTGGTCTCCGCGCTGCACCACTGCTTCGACGGCCCCAC
GGGGGAGCTGGCCCACGCCTTCTTCCCCCCGCACGGCGGCATCCACTTCGACGACAGCGAGTACTGGGTCCTGGGCCCCACGCGCTACAG
CTGGAAGAAAGGCGTGTGGCTCACGGACCTGGTGCACGTGGCGGCCCACGAGATCGGCCACGCGCTGGGCCTGATGCACTCACAACACGG
CCGGGCGCTCATGCACCTGAACGCCACGCTGCGCGGCTGGAAGGCGTTGTCCCAGGACGAGCTGTGGGGGCTGCACCGGCTCTACGGATG
CCTCGACAGGCTGTTCGTGTGCGCGTCCTGGGCGCGGAGGGGCTTCTGCGACGCTCGCCGGCGGCTCATGAAGAGGCTCTGCCCCAGCAG
CTGCGACTTCTGCTACGAATTCCCCTTCCCCACGGTGGCCACCACCCCACCGCCCCCCAGGACCAAAACCAGGCTGGTGCCCGAGGGCAG
GAACGTGACCTTCCGCTGCGGCCAGAAGATCCTCCACAAGAAAGGGAAAGTGTACTGGTACAAGGACCAGGAGCCCCTGGAGTTCTCCTA
CCCCGGCTACCTGGCCCTGGGCGAGGCGCACCTGAGCATCATCGCCAACGCCGTCAATGAGGGCACCTACACCTGCGTGGTGCGCCGCCA

>91847_91847_3_TMEM189-MMP23B_TMEM189_chr20_48744511_ENST00000371656_MMP23B_chr1_1568566_ENST00000356026_length(amino acids)=403AA_BP=155
MNERAIAGALIADFLSGLVHWGADTWGSVELPIVGKAFIRPFREHHIDPTAITRHDFIETNGDNCLVTLLPLLNMAYKFRTHSPEALEQL
YPWECFVFCLIIFGTFTNQIHKWSHTYFGLPRWVTLLQDWHVILPRKHHRIHHVSPHETYFCITTGFYPINHTDCLVSALHHCFDGPTGE
LAHAFFPPHGGIHFDDSEYWVLGPTRYSWKKGVWLTDLVHVAAHEIGHALGLMHSQHGRALMHLNATLRGWKALSQDELWGLHRLYGCLD
RLFVCASWARRGFCDARRRLMKRLCPSSCDFCYEFPFPTVATTPPPPRTKTRLVPEGRNVTFRCGQKILHKKGKVYWYKDQEPLEFSYPG

--------------------------------------------------------------
>91847_91847_4_TMEM189-MMP23B_TMEM189_chr20_48744511_ENST00000557021_MMP23B_chr1_1568566_ENST00000356026_length(transcript)=1627nt_BP=852nt
AGCCCCGATTGGCTGTGACGCGCGGCCGGGCGAGGACCCCGCCCGCGCCGCCGCCGCGCCCGGCGCTGGGCGGTCATTGGGCGGCGTGAT
CTCGCCGCGGTTCCGCGGCCCTGCCGCCGCCGCCGCCAGCAGAGCGCACCGGGCCGATCGGGCGAGTGGCCATGGCGGGCGCCGAGAACT
GGCCGGGCCAGCAGCTGGAGCTGGACGAGGACGAGGCGTCTTGTTGCCGCTGGGGCGCGCAGCACGCCGGGGCCCGCGAGCTGGCTGCGC
TCTACTCGCCAGGCAAGCGCCTCCAGGAGTGGTGCTCTGTGATCCTGTGCTTCAGCCTCATCGCCCACAACCTGGTCCATCTCCTGCTGC
TGGCCCGCTGGGAGGACACACCCCTCGTCATACTCGGTGTTGTTGCAGGGGCTCTCATTGCTGACTTCTTGTCTGGCCTGGTACACTGGG
GTGCTGACACATGGGGCTCTGTGGAGCTGCCCATTGTGGGGAAGGCTTTCATCCGACCCTTCCGGGAGCACCACATTGACCCGACAGCTA
TCACACGGCACGACTTCATCGAGACCAACGGGGACAACTGCCTGGTGACACTGCTGCCGCTGCTAAACATGGCCTACAAGTTCCGCACCC
ACAGCCCTGAAGCCCTGGAGCAGCTATACCCCTGGGAGTGCTTCGTCTTCTGCCTGATCATCTTCGGCACCTTCACCAACCAGATCCACA
AGTGGTCGCACACGTACTTTGGGCTGCCACGCTGGGTCACCCTCCTGCAGGACTGGCATGTCATCCTGCCACGTAAACACCATCGCATCC
ACCACGTCTCACCCCACGAGACCTACTTCTGCATCACCACAGGCTTCTACCCGATCAACCACACGGACTGCCTGGTCTCCGCGCTGCACC
ACTGCTTCGACGGCCCCACGGGGGAGCTGGCCCACGCCTTCTTCCCCCCGCACGGCGGCATCCACTTCGACGACAGCGAGTACTGGGTCC
TGGGCCCCACGCGCTACAGCTGGAAGAAAGGCGTGTGGCTCACGGACCTGGTGCACGTGGCGGCCCACGAGATCGGCCACGCGCTGGGCC
TGATGCACTCACAACACGGCCGGGCGCTCATGCACCTGAACGCCACGCTGCGCGGCTGGAAGGCGTTGTCCCAGGACGAGCTGTGGGGGC
TGCACCGGCTCTACGGATGCCTCGACAGGCTGTTCGTGTGCGCGTCCTGGGCGCGGAGGGGCTTCTGCGACGCTCGCCGGCGGCTCATGA
AGAGGCTCTGCCCCAGCAGCTGCGACTTCTGCTACGAATTCCCCTTCCCCACGGTGGCCACCACCCCACCGCCCCCCAGGACCAAAACCA
GGCTGGTGCCCGAGGGCAGGAACGTGACCTTCCGCTGCGGCCAGAAGATCCTCCACAAGAAAGGGAAAGTGTACTGGTACAAGGACCAGG
AGCCCCTGGAGTTCTCCTACCCCGGCTACCTGGCCCTGGGCGAGGCGCACCTGAGCATCATCGCCAACGCCGTCAATGAGGGCACCTACA
CCTGCGTGGTGCGCCGCCAGCAGCGCGTGCTGACCACCTACTCCTGGCGAGTCCGTGTGCGGGGCTGAGCCCGGCTGATAAAGCACTTTC

>91847_91847_4_TMEM189-MMP23B_TMEM189_chr20_48744511_ENST00000557021_MMP23B_chr1_1568566_ENST00000356026_length(amino acids)=495AA_BP=247
MPPPPPAERTGPIGRVAMAGAENWPGQQLELDEDEASCCRWGAQHAGARELAALYSPGKRLQEWCSVILCFSLIAHNLVHLLLLARWEDT
PLVILGVVAGALIADFLSGLVHWGADTWGSVELPIVGKAFIRPFREHHIDPTAITRHDFIETNGDNCLVTLLPLLNMAYKFRTHSPEALE
QLYPWECFVFCLIIFGTFTNQIHKWSHTYFGLPRWVTLLQDWHVILPRKHHRIHHVSPHETYFCITTGFYPINHTDCLVSALHHCFDGPT
GELAHAFFPPHGGIHFDDSEYWVLGPTRYSWKKGVWLTDLVHVAAHEIGHALGLMHSQHGRALMHLNATLRGWKALSQDELWGLHRLYGC
LDRLFVCASWARRGFCDARRRLMKRLCPSSCDFCYEFPFPTVATTPPPPRTKTRLVPEGRNVTFRCGQKILHKKGKVYWYKDQEPLEFSY

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Fusion Gene PPI Analysis for TMEM189-MMP23B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMEM189-MMP23B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMEM189-MMP23B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource