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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AFF3-HDAC5 (FusionGDB2 ID:HG3899TG10014)

Fusion Gene Summary for AFF3-HDAC5

check button Fusion gene summary
Fusion gene informationFusion gene name: AFF3-HDAC5
Fusion gene ID: hg3899tg10014
HgeneTgene
Gene symbol

AFF3

HDAC5

Gene ID

3899

10014

Gene nameAF4/FMR2 family member 3histone deacetylase 5
SynonymsLAF4|MLLT2-likeHD5|NY-CO-9
Cytomap('AFF3')('HDAC5')

2q11.2

17q21.31

Type of geneprotein-codingprotein-coding
DescriptionAF4/FMR2 family member 3MLLT2-related proteinlymphoid nuclear protein 4lymphoid nuclear protein related to AF4protein LAF-4histone deacetylase 5antigen NY-CO-9
Modification date2020031320200313
UniProtAcc

P51826

.
Ensembl transtripts involved in fusion geneENST00000317233, ENST00000356421, 
ENST00000409236, ENST00000409579, 
ENST00000483600, 
Fusion gene scores* DoF score17 X 13 X 7=154713 X 11 X 8=1144
# samples 1714
** MAII scorelog2(17/1547*10)=-3.18586654531133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1144*10)=-3.03058831983342
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AFF3 [Title/Abstract] AND HDAC5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAFF3(100623094)-HDAC5(42195072), # samples:1
AFF3(100623094)-HDAC5(42171202), # samples:1
Anticipated loss of major functional domain due to fusion event.AFF3-HDAC5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AFF3-HDAC5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AFF3-HDAC5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AFF3-HDAC5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AFF3-HDAC5 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
AFF3-HDAC5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
AFF3-HDAC5 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
AFF3-HDAC5 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHDAC5

GO:0000122

negative regulation of transcription by RNA polymerase II

16236793

TgeneHDAC5

GO:0016575

histone deacetylation

10869435


check buttonFusion gene breakpoints across AFF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across HDAC5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-YL-A8HO-01AAFF3chr2

100623094

-HDAC5chr17

42171202

-
ChimerDB4PRADTCGA-YL-A8HO-01AAFF3chr2

100623094

-HDAC5chr17

42195072

-


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Fusion Gene ORF analysis for AFF3-HDAC5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000317233ENST00000225983AFF3chr2

100623094

-HDAC5chr17

42195072

-
5CDS-5UTRENST00000317233ENST00000336057AFF3chr2

100623094

-HDAC5chr17

42195072

-
5CDS-5UTRENST00000317233ENST00000393622AFF3chr2

100623094

-HDAC5chr17

42195072

-
5CDS-5UTRENST00000317233ENST00000586802AFF3chr2

100623094

-HDAC5chr17

42195072

-
5CDS-5UTRENST00000356421ENST00000225983AFF3chr2

100623094

-HDAC5chr17

42195072

-
5CDS-5UTRENST00000356421ENST00000336057AFF3chr2

100623094

-HDAC5chr17

42195072

-
5CDS-5UTRENST00000356421ENST00000393622AFF3chr2

100623094

-HDAC5chr17

42195072

-
5CDS-5UTRENST00000356421ENST00000586802AFF3chr2

100623094

-HDAC5chr17

42195072

-
5CDS-5UTRENST00000409236ENST00000225983AFF3chr2

100623094

-HDAC5chr17

42195072

-
5CDS-5UTRENST00000409236ENST00000336057AFF3chr2

100623094

-HDAC5chr17

42195072

-
5CDS-5UTRENST00000409236ENST00000393622AFF3chr2

100623094

-HDAC5chr17

42195072

-
5CDS-5UTRENST00000409236ENST00000586802AFF3chr2

100623094

-HDAC5chr17

42195072

-
5CDS-5UTRENST00000409579ENST00000225983AFF3chr2

100623094

-HDAC5chr17

42195072

-
5CDS-5UTRENST00000409579ENST00000336057AFF3chr2

100623094

-HDAC5chr17

42195072

-
5CDS-5UTRENST00000409579ENST00000393622AFF3chr2

100623094

-HDAC5chr17

42195072

-
5CDS-5UTRENST00000409579ENST00000586802AFF3chr2

100623094

-HDAC5chr17

42195072

-
Frame-shiftENST00000317233ENST00000225983AFF3chr2

100623094

-HDAC5chr17

42171202

-
Frame-shiftENST00000317233ENST00000336057AFF3chr2

100623094

-HDAC5chr17

42171202

-
Frame-shiftENST00000317233ENST00000393622AFF3chr2

100623094

-HDAC5chr17

42171202

-
Frame-shiftENST00000317233ENST00000586802AFF3chr2

100623094

-HDAC5chr17

42171202

-
Frame-shiftENST00000356421ENST00000225983AFF3chr2

100623094

-HDAC5chr17

42171202

-
Frame-shiftENST00000356421ENST00000336057AFF3chr2

100623094

-HDAC5chr17

42171202

-
Frame-shiftENST00000356421ENST00000393622AFF3chr2

100623094

-HDAC5chr17

42171202

-
Frame-shiftENST00000356421ENST00000586802AFF3chr2

100623094

-HDAC5chr17

42171202

-
Frame-shiftENST00000409579ENST00000225983AFF3chr2

100623094

-HDAC5chr17

42171202

-
Frame-shiftENST00000409579ENST00000336057AFF3chr2

100623094

-HDAC5chr17

42171202

-
Frame-shiftENST00000409579ENST00000393622AFF3chr2

100623094

-HDAC5chr17

42171202

-
Frame-shiftENST00000409579ENST00000586802AFF3chr2

100623094

-HDAC5chr17

42171202

-
In-frameENST00000409236ENST00000225983AFF3chr2

100623094

-HDAC5chr17

42171202

-
In-frameENST00000409236ENST00000336057AFF3chr2

100623094

-HDAC5chr17

42171202

-
In-frameENST00000409236ENST00000393622AFF3chr2

100623094

-HDAC5chr17

42171202

-
In-frameENST00000409236ENST00000586802AFF3chr2

100623094

-HDAC5chr17

42171202

-
intron-3CDSENST00000483600ENST00000225983AFF3chr2

100623094

-HDAC5chr17

42171202

-
intron-3CDSENST00000483600ENST00000336057AFF3chr2

100623094

-HDAC5chr17

42171202

-
intron-3CDSENST00000483600ENST00000393622AFF3chr2

100623094

-HDAC5chr17

42171202

-
intron-3CDSENST00000483600ENST00000586802AFF3chr2

100623094

-HDAC5chr17

42171202

-
intron-5UTRENST00000483600ENST00000225983AFF3chr2

100623094

-HDAC5chr17

42195072

-
intron-5UTRENST00000483600ENST00000336057AFF3chr2

100623094

-HDAC5chr17

42195072

-
intron-5UTRENST00000483600ENST00000393622AFF3chr2

100623094

-HDAC5chr17

42195072

-
intron-5UTRENST00000483600ENST00000586802AFF3chr2

100623094

-HDAC5chr17

42195072

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409236AFF3chr2100623094-ENST00000225983HDAC5chr1742171202-589198689242601122
ENST00000409236AFF3chr2100623094-ENST00000393622HDAC5chr1742171202-588498689242601122
ENST00000409236AFF3chr2100623094-ENST00000336057HDAC5chr1742171202-562898689240051037
ENST00000409236AFF3chr2100623094-ENST00000586802HDAC5chr1742171202-434398689242601122

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409236ENST00000225983AFF3chr2100623094-HDAC5chr1742171202-0.0121211750.98787886
ENST00000409236ENST00000393622AFF3chr2100623094-HDAC5chr1742171202-0.0122917990.9877082
ENST00000409236ENST00000336057AFF3chr2100623094-HDAC5chr1742171202-0.0153475480.98465246
ENST00000409236ENST00000586802AFF3chr2100623094-HDAC5chr1742171202-0.0236526320.9763474

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Fusion Genomic Features for AFF3-HDAC5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for AFF3-HDAC5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:100623094/chr17:42195072)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AFF3

P51826

.
FUNCTION: Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHDAC5chr2:100623094chr17:42171202ENST000002259832271099_1104321124.0Compositional biasNote=Poly-Ala
TgeneHDAC5chr2:100623094chr17:42171202ENST0000022598322747_52321124.0Compositional biasNote=Poly-Gly
TgeneHDAC5chr2:100623094chr17:42171202ENST00000225983227596_599321124.0Compositional biasNote=Poly-Glu
TgeneHDAC5chr2:100623094chr17:42171202ENST0000022598322785_92321124.0Compositional biasNote=Poly-Gln
TgeneHDAC5chr2:100623094chr17:42171202ENST000003360572251099_1104311038.0Compositional biasNote=Poly-Ala
TgeneHDAC5chr2:100623094chr17:42171202ENST0000033605722547_52311038.0Compositional biasNote=Poly-Gly
TgeneHDAC5chr2:100623094chr17:42171202ENST00000336057225596_599311038.0Compositional biasNote=Poly-Glu
TgeneHDAC5chr2:100623094chr17:42171202ENST0000033605722585_92311038.0Compositional biasNote=Poly-Gln
TgeneHDAC5chr2:100623094chr17:42171202ENST000003936222271099_1104311123.0Compositional biasNote=Poly-Ala
TgeneHDAC5chr2:100623094chr17:42171202ENST0000039362222747_52311123.0Compositional biasNote=Poly-Gly
TgeneHDAC5chr2:100623094chr17:42171202ENST00000393622227596_599311123.0Compositional biasNote=Poly-Glu
TgeneHDAC5chr2:100623094chr17:42171202ENST0000039362222785_92311123.0Compositional biasNote=Poly-Gln
TgeneHDAC5chr2:100623094chr17:42171202ENST000005868022271099_1104311123.0Compositional biasNote=Poly-Ala
TgeneHDAC5chr2:100623094chr17:42171202ENST0000058680222747_52311123.0Compositional biasNote=Poly-Gly
TgeneHDAC5chr2:100623094chr17:42171202ENST00000586802227596_599311123.0Compositional biasNote=Poly-Glu
TgeneHDAC5chr2:100623094chr17:42171202ENST0000058680222785_92311123.0Compositional biasNote=Poly-Gln
TgeneHDAC5chr2:100623094chr17:42171202ENST000002259832271081_1122321124.0MotifNote=Nuclear export signal
TgeneHDAC5chr2:100623094chr17:42171202ENST000003360572251081_1122311038.0MotifNote=Nuclear export signal
TgeneHDAC5chr2:100623094chr17:42171202ENST000003936222271081_1122311123.0MotifNote=Nuclear export signal
TgeneHDAC5chr2:100623094chr17:42171202ENST000005868022271081_1122311123.0MotifNote=Nuclear export signal
TgeneHDAC5chr2:100623094chr17:42171202ENST00000225983227684_1028321124.0RegionNote=Histone deacetylase
TgeneHDAC5chr2:100623094chr17:42171202ENST00000336057225684_1028311038.0RegionNote=Histone deacetylase
TgeneHDAC5chr2:100623094chr17:42171202ENST00000393622227684_1028311123.0RegionNote=Histone deacetylase
TgeneHDAC5chr2:100623094chr17:42171202ENST00000586802227684_1028311123.0RegionNote=Histone deacetylase

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAFF3chr2:100623094chr17:42171202ENST00000317233-624413_4192911227.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000317233-624422_4322911227.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000317233-624440_4452911227.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000317233-624670_6792911227.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000356421-624413_4193161252.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000356421-624422_4323161252.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000356421-624440_4453161252.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000356421-624670_6793161252.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000409236-523413_4192911227.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000409236-523422_4322911227.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000409236-523440_4452911227.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000409236-523670_6792911227.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000409579-725413_4193161252.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000409579-725422_4323161252.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000409579-725440_4453161252.0Compositional biasNote=Poly-Ser
HgeneAFF3chr2:100623094chr17:42171202ENST00000409579-725670_6793161252.0Compositional biasNote=Poly-Ser


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Fusion Gene Sequence for AFF3-HDAC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2685_2685_1_AFF3-HDAC5_AFF3_chr2_100623094_ENST00000409236_HDAC5_chr17_42171202_ENST00000225983_length(transcript)=5891nt_BP=986nt
GAGCTCGCTGCTCTCTCTTGAGTGTGCCTGCGCGCAAGCCGGGGAGCGGCGCGCGGGCGGCCCGAGCCTCGGCGGCGGCGGTAGCGGCGG
CGGCGACGCTGACACCTCCCACCATGGACAGCTTCGACTTAGCCCTGCTCCAGGAATGGGACCTCGAGTCACTGTGTGTCTATGAACCAG
ATAGAAATGCATTACGGAGGAAAGAACGAGAAAGAAGAAATCAAGAAACTCAACAGGATGATGGCACGTTTAATTCTAGTTACTCTCTCT
TCAGTGAGCCCTACAAGACTAACAAGGGGGATGAACTCTCCAACCGGATCCAGAACACTTTAGGCAATTATGATGAAATGAAAGACTTTT
TAACTGATAGATCCAATCAGAGTCATCTCGTTGGAGTTCCCAAACCTGGGGTTCCTCAGACTCCTGTGAACAAGATCGATGAACATTTTG
TTGCAGATTCAAGAGCCCAGAACCAGCCCTCGTCTATCTGTAGCACTACAACTTCCACACCAGCAGCTGTCCCCGTGCAGCAGAGTAAGA
GAGGCACTATGGGCTGGCAGAAGGCTGGGCACCCACCCTCTGACGGCCAACAGAGAGCAACACAACAGGGCTCTCTCAGGACCTTGCTTG
GAGATGGTGTTGGCAGACAGCAGCCTCGGGCCAAACAAGTGTGCAATGTGGAGGTGGGCCTTCAGACCCAGGAGAGGCCACCTGCCATGG
CGGCCAAGCACAGCAGCAGCGGACACTGTGTTCAGAACTTTCCTCCATCCCTAGCTTCAAAACCCAGCCTGGTCCAGCAGAAACCGACCG
CGTATGTGAGGCCAATGGACGGCCAAGATCAGGCCCCTGATGAGTCTCCTAAGCTGAAGTCGTCTTCGGAAACCAGCGTGCACTGCACAT
CATACAGGGGAGTCCCTGCCAGCAAGCCGGAGCCTGCCAGAGCCAAGGCCAAGCTCTCCAAGTTCAGCATCCCCAAGCAGGGGGAGTGGA
GGTGAAGCCGGTGCTGCCAAGAGCCATGCCCAGTTCCATGGGGGGTGGGGGTGGAGGCAGCCCCAGCCCTGTGGAGCTACGGGGGGCTCT
GGTGGGCTCTGTGGACCCCACACTGCGGGAGCAGCAACTGCAGCAGGAGCTCCTGGCGCTCAAGCAGCAGCAGCAGCTGCAGAAGCAGCT
CCTGTTCGCTGAGTTCCAGAAACAGCATGACCACCTGACAAGGCAGCATGAGGTCCAGCTGCAGAAGCACCTCAAGCAGCAGCAGGAGAT
GCTGGCAGCCAAGCAGCAGCAGGAGATGCTGGCAGCCAAGCGGCAGCAGGAGCTGGAGCAGCAGCGGCAGCGGGAGCAGCAGCGGCAGGA
AGAGCTGGAGAAGCAGCGGCTGGAGCAGCAGCTGCTCATCCTGCGGAACAAGGAGAAGAGCAAAGAGAGTGCCATTGCCAGCACTGAGGT
AAAGCTGAGGCTCCAGGAATTCCTCTTGTCGAAGTCAAAGGAGCCCACACCAGGCGGCCTCAACCATTCCCTCCCACAGCACCCCAAATG
CTGGGGAGCCCACCATGCTTCTTTGGACCAGAGTTCCCCTCCCCAGAGCGGCCCCCCTGGGACGCCTCCCTCCTACAAACTGCCTTTGCC
TGGGCCCTACGACAGTCGAGACGACTTCCCCCTCCGCAAAACAGCCTCTGAACCCAACTTGAAAGTGCGTTCAAGGCTAAAACAGAAGGT
GGCTGAGCGGAGAAGCAGTCCCCTCCTGCGTCGCAAGGATGGGACTGTTATTAGCACCTTTAAGAAGAGAGCTGTTGAGATCACAGGTGC
CGGGCCTGGGGCGTCGTCCGTGTGTAACAGCGCACCCGGCTCCGGCCCCAGCTCTCCCAACAGCTCCCACAGCACCATCGCTGAGAATGG
CTTTACTGGCTCAGTCCCCAACATCCCCACTGAGATGCTCCCTCAGCACCGAGCCCTCCCTCTGGACAGCTCCCCCAACCAGTTCAGCCT
CTACACGTCTCCTTCTCTGCCCAACATCTCCCTAGGGCTGCAGGCCACGGTCACTGTCACCAACTCACACCTCACTGCCTCCCCGAAGCT
GTCGACACAGCAGGAGGCCGAGAGGCAGGCCCTCCAGTCCCTGCGGCAGGGTGGCACGCTGACCGGCAAGTTCATGAGCACATCCTCTAT
TCCTGGCTGCCTGCTGGGCGTGGCACTGGAGGGCGACGGGAGCCCCCACGGGCATGCCTCCCTGCTGCAGCATGTGCTGTTGCTGGAGCA
GGCCCGGCAGCAGAGCACCCTCATTGCTGTGCCACTCCACGGGCAGTCCCCACTAGTGACGGGTGAACGTGTGGCCACCAGCATGCGGAC
GGTAGGCAAGCTCCCGCGGCATCGGCCCCTGAGCCGCACTCAGTCCTCACCGCTGCCGCAGAGTCCCCAGGCCCTGCAGCAGCTGGTCAT
GCAACAACAGCACCAGCAGTTCCTGGAGAAGCAGAAGCAGCAGCAGCTACAGCTGGGCAAGATCCTCACCAAGACAGGGGAGCTGCCCAG
GCAGCCCACCACCCACCCTGAGGAGACAGAGGAGGAGCTGACGGAGCAGCAGGAGGTCTTGCTGGGGGAGGGAGCCCTGACCATGCCCCG
GGAGGGCTCCACAGAGAGTGAGAGCACACAGGAAGACCTGGAGGAGGAGGACGAGGAAGACGATGGGGAGGAGGAGGAGGATTGCATCCA
GGTTAAGGACGAGGAGGGCGAGAGTGGTGCTGAGGAGGGGCCCGACTTGGAGGAGCCTGGTGCTGGATACAAAAAACTGTTCTCAGATGC
CCAGCCGCTGCAGCCTTTGCAGGTGTACCAGGCGCCCCTCAGCCTGGCCACTGTGCCCCACCAGGCCCTGGGCCGTACCCAGTCCTCCCC
TGCTGCCCCTGGGGGCATGAAGAGCCCCCCAGACCAGCCCGTCAAGCACCTCTTCACCACAGGTGTGGTCTACGACACGTTCATGCTAAA
GCACCAGTGCATGTGCGGGAACACACACGTGCACCCTGAGCATGCTGGCCGGATCCAGAGCATCTGGTCCCGGCTGCAGGAGACAGGCCT
GCTTAGCAAGTGCGAGCGGATCCGAGGTCGCAAAGCCACGCTAGATGAGATCCAGACAGTGCACTCTGAATACCACACCCTGCTCTATGG
GACCAGTCCCCTCAACCGGCAGAAGCTAGACAGCAAGAAGTTGCTCGGCCCCATCAGCCAGAAGATGTATGCTGTGCTGCCTTGTGGGGG
CATCGGGGTGGACAGTGACACCGTGTGGAATGAGATGCACTCCTCCAGTGCTGTGCGCATGGCAGTGGGCTGCCTGCTGGAGCTGGCCTT
CAAGGTGGCTGCAGGAGAGCTCAAGAATGGATTTGCCATCATCCGGCCCCCAGGACACCACGCCGAGGAATCCACAGCCATGGGATTCTG
CTTCTTCAACTCTGTAGCCATCACCGCAAAACTCCTACAGCAGAAGTTGAACGTGGGCAAGGTCCTCATCGTGGACTGGGACATTCACCA
TGGCAATGGCACCCAGCAGGCGTTCTACAATGACCCCTCTGTGCTCTACATCTCTCTGCATCGCTATGACAACGGGAACTTCTTTCCAGG
CTCTGGGGCTCCTGAAGAGGTTGGTGGAGGACCAGGCGTGGGGTACAATGTGAACGTGGCATGGACAGGAGGTGTGGACCCCCCCATTGG
AGACGTGGAGTACCTTACAGCCTTCAGGACAGTGGTGATGCCCATTGCCCACGAGTTCTCACCTGATGTGGTCCTAGTCTCCGCCGGGTT
TGATGCTGTTGAAGGACATCTGTCTCCTCTGGGTGGCTACTCTGTCACCGCCAGATGTTTTGGCCACTTGACCAGGCAGCTGATGACCCT
GGCAGGGGGCCGGGTGGTGCTGGCCCTGGAGGGAGGCCATGACTTGACCGCCATCTGTGATGCCTCTGAGGCTTGTGTCTCGGCTCTGCT
CAGTGTAGAGCTGCAGCCCTTGGATGAGGCAGTCTTGCAGCAAAAGCCCAACATCAACGCAGTGGCCACGCTAGAGAAAGTCATCGAGAT
CCAGAGCAAACACTGGAGCTGTGTGCAGAAGTTCGCCGCTGGTCTGGGCCGGTCCCTGCGAGAGGCCCAAGCAGGTGAGACCGAGGAGGC
CGAGACTGTGAGCGCCATGGCCTTGCTGTCGGTGGGGGCCGAGCAGGCCCAGGCTGCGGCAGCCCGGGAACACAGCCCCAGGCCGGCAGA
GGAGCCCATGGAGCAGGAGCCTGCCCTGTGACGCCCCGGCCCCCATCCCTCTGGGCTTCACCATTGTGATTTTGTTTATTTTTTCTATTA
AAAACAAAAAGTCACACATTCAACAAGGTGTGCCGTGTGGGTCTCTCAGCCTTGCCCCTCCTGCTCCTCTACGCTGCCTCAGGCCCCCAG
CCCTGTGGCTTCCACCTCAGCTCTAGAAGCCTGCTCCCTCTGCAGGGGGTGGTGGTGTCTTCCCAGCCCTGTCCCATGTGTCCCTCCCCC
CATTTTCCTGCATTCTGTCTGTCCTTTTCCTCCTTGGAGCCTGGGCCAGCTCAAGGTGGGCACGGGGGCCCAGACAGTACTCTCCAGTTC
TGGGGCCCCCCGAGTGAGGAGGGAACGGGAAGTCGGTGCCTTGGTTTCAGCTGATTTGGGGGGAAATGCCTTAATTTCACTCTCCTCCCT
TCTCCAGCCTCAGGGGAGGATCTGGAGGATCCACTACTGTCTTTAAGATGCAGAGTGGAGGGGAGGTGGGCACCCACCCTGCGATTCTCC
ACCCTTTCCCCTTCTTTCGTCCTCACCATCTCTGCAGACCCCTCTCCTCCTCCTTCCTCTTGGTCTCAGCACTGATGGGAGGCTGGTGCC
CAAGCTGTGGCCTGCAGTCTGTGAGGAGGGCTGTCTTGCCTCACACTCCTCACAGCCTACTTCCCCTTCCCCGGGGCTGAGAGGGTGAAA
GTGTGTGGGGAAGGAGAGGACTGGTTTCCTGGGTTCTCAGGGGCCAGGAGGAGTAACAGAACCAGGTCTGCTCCCCACCTTACTCGGATG
GCCTCCCTGCCCCTCTGCTGGCACAGCCTGGGCAAGGGGAGAAGGTGGTCCCTGCAGAGGGGCTCCAGGCTGGTGAGAGCCCCCCTGCTG
TCAGGACCAGATTTTCCCAGCCATCCAGCATGCTGCGGGGAGAAGGGGCAGAGGCTCACCTCCCTCCTGGGGCCTTTTGTTTTGGATCCT
GGGGATGGTGAGAATGGAGGTTCTAGAAGGGGTAAGGCCAGAACCCAGGGATCCAGGAGTCGGCTCTCAGCTGGAGCTTCCATACCTTCT
GGGCTCCCTTTGCTGACCACCAGCCCAAGGGAGCTAAGACCAGGAGGGGGCTGGGCGCTGTCCCTTCTCTTTCCCAGGAGCCCTGCCAGG
GGCTGTGGGCCTACAAGGCTTCCAGGGGATGCCATCCAGCCTGTAGGAAACCAAAGATGGGAAGTGGCTCCTAGGGGGCTGACTCTTCCT
TCCTCCTCCTCCCCAGTACCACATATACTTTCTCTCCTTCTATCTCCAGGGCCCCACCAATCTGTTTACATATTTATTATCCTATGGGGG
CCTGAGCAGGATTGAGGGAGCCAGGGGAGGGGCAGGAGTCCCAGCACCATCGGTTCATAGTGTGCTTGTGTGTTTGTTTTAGATCCTCCT
GGGGGATGGGGATGGGGCCAGGCTCAGTGTACTAGGCCTCTCTGTGCTGAGCCCCAGGCTCCCGGCCCCTTACCCACTCTCTCCCTGTGG
CTGGTCTGGTTCTCATGTAAACCCACTCCTTGCTTTGTCTCCCTGGATATGGATTTCAGTTAAGTATTTTGTAACCCGTTACACTGTGTG

>2685_2685_1_AFF3-HDAC5_AFF3_chr2_100623094_ENST00000409236_HDAC5_chr17_42171202_ENST00000225983_length(amino acids)=1122AA_BP=31
MHIIQGSPCQQAGACQSQGQALQVQHPQAGGVEVKPVLPRAMPSSMGGGGGGSPSPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQ
KQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIAS
TEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLK
QKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPNQ
FSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLL
LEQARQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGE
LPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLF
SDAQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQE
TGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLE
LAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNF
FPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQL
MTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGET

--------------------------------------------------------------
>2685_2685_2_AFF3-HDAC5_AFF3_chr2_100623094_ENST00000409236_HDAC5_chr17_42171202_ENST00000336057_length(transcript)=5628nt_BP=986nt
GAGCTCGCTGCTCTCTCTTGAGTGTGCCTGCGCGCAAGCCGGGGAGCGGCGCGCGGGCGGCCCGAGCCTCGGCGGCGGCGGTAGCGGCGG
CGGCGACGCTGACACCTCCCACCATGGACAGCTTCGACTTAGCCCTGCTCCAGGAATGGGACCTCGAGTCACTGTGTGTCTATGAACCAG
ATAGAAATGCATTACGGAGGAAAGAACGAGAAAGAAGAAATCAAGAAACTCAACAGGATGATGGCACGTTTAATTCTAGTTACTCTCTCT
TCAGTGAGCCCTACAAGACTAACAAGGGGGATGAACTCTCCAACCGGATCCAGAACACTTTAGGCAATTATGATGAAATGAAAGACTTTT
TAACTGATAGATCCAATCAGAGTCATCTCGTTGGAGTTCCCAAACCTGGGGTTCCTCAGACTCCTGTGAACAAGATCGATGAACATTTTG
TTGCAGATTCAAGAGCCCAGAACCAGCCCTCGTCTATCTGTAGCACTACAACTTCCACACCAGCAGCTGTCCCCGTGCAGCAGAGTAAGA
GAGGCACTATGGGCTGGCAGAAGGCTGGGCACCCACCCTCTGACGGCCAACAGAGAGCAACACAACAGGGCTCTCTCAGGACCTTGCTTG
GAGATGGTGTTGGCAGACAGCAGCCTCGGGCCAAACAAGTGTGCAATGTGGAGGTGGGCCTTCAGACCCAGGAGAGGCCACCTGCCATGG
CGGCCAAGCACAGCAGCAGCGGACACTGTGTTCAGAACTTTCCTCCATCCCTAGCTTCAAAACCCAGCCTGGTCCAGCAGAAACCGACCG
CGTATGTGAGGCCAATGGACGGCCAAGATCAGGCCCCTGATGAGTCTCCTAAGCTGAAGTCGTCTTCGGAAACCAGCGTGCACTGCACAT
CATACAGGGGAGTCCCTGCCAGCAAGCCGGAGCCTGCCAGAGCCAAGGCCAAGCTCTCCAAGTTCAGCATCCCCAAGCAGGGGGAGTGGA
GGTGAAGCCGGTGCTGCCAAGAGCCATGCCCAGTTCCATGGGGGGTGGGGGTGGAGGCAGCCCCAGCCCTGTGGAGCTACGGGGGGCTCT
GGTGGGCTCTGTGGACCCCACACTGCGGGAGCAGCAACTGCAGCAGGAGCTCCTGGCGCTCAAGCAGCAGCAGCAGCTGCAGAAGCAGCT
CCTGTTCGCTGAGTTCCAGAAACAGCATGACCACCTGACAAGGCAGCATGAGGTCCAGCTGCAGAAGCACCTCAAGCAGCAGCAGGAGAT
GCTGGCAGCCAAGCAGCAGCAGGAGATGCTGGCAGCCAAGCGGCAGCAGGAGCTGGAGCAGCAGCGGCAGCGGGAGCAGCAGCGGCAGGA
AGAGCTGGAGAAGCAGCGGCTGGAGCAGCAGCTGCTCATCCTGCGGAACAAGGAGAAGAGCAAAGAGAGTGCCATTGCCAGCACTGAGGT
AAAGCTGAGGCTCCAGGAATTCCTCTTGTCGAAGTCAAAGGAGCCCACACCAGGCGGCCTCAACCATTCCCTCCCACAGCACCCCAAATG
CTGGGGAGCCCACCATGCTTCTTTGGACCAGAGTTCCCCTCCCCAGAGCGGCCCCCCTGGGACGCCTCCCTCCTACAAACTGCCTTTGCC
TGGGCCCTACGACAGTCGAGACGACTTCCCCCTCCGCAAAACAGCCTCTGAACCCAACTTGAAAGTGCGTTCAAGGCTAAAACAGAAGGT
GGCTGAGCGGAGAAGCAGTCCCCTCCTGCGTCGCAAGGATGGGACTGTTATTAGCACCTTTAAGAAGAGAGCTGTTGAGATCACAGGTGC
CGGGCCTGGGGCGTCGTCCGTGTGTAACAGCGCACCCGGCTCCGGCCCCAGCTCTCCCAACAGCTCCCACAGCACCATCGCTGAGAATGG
CTTTACTGGCTCAGTCCCCAACATCCCCACTGAGATGCTCCCTCAGCACCGAGCCCTCCCTCTGGACAGCTCCCCCAACCAGTTCAGCCT
CTACACGTCTCCTTCTCTGCCCAACATCTCCCTAGGGCTGCAGGCCACGGTCACTGTCACCAACTCACACCTCACTGCCTCCCCGAAGCT
GTCGACACAGCAGGAGGCCGAGAGGCAGGCCCTCCAGTCCCTGCGGCAGGGTGGCACGCTGACCGGCAAGTTCATGAGCACATCCTCTAT
TCCTGGCTGCCTGCTGGGCGTGGCACTGGAGGGCGACGGGAGCCCCCACGGGCATGCCTCCCTGCTGCAGCATGTGCTGTTGCTGGAGCA
GGCCCGGCAGCAGAGCACCCTCATTGCTGTGCCACTCCACGGGCAGTCCCCACTAGTGACGGGTGAACGTGTGGCCACCAGCATGCGGAC
GGTAGGCAAGCTCCCGCGGCATCGGCCCCTGAGCCGCACTCAGTCCTCACCGCTGCCGCAGAGTCCCCAGGCCCTGCAGCAGCTGGTCAT
GCAACAACAGCACCAGCAGTTCCTGGAGAAGCAGAAGCAGCAGCAGCTACAGCTGGGCAAGATCCTCACCAAGACAGGGGAGCTGCCCAG
GCAGCCCACCACCCACCCTGAGGAGACAGAGGAGGAGCTGACGGAGCAGCAGGAGGTCTTGCTGGGGGAGGGAGCCCTGACCATGCCCCG
GGAGGGCTCCACAGAGAGTGAGAGCACACAGGAAGACCTGGAGGAGGAGGACGAGGAAGACGATGGGGAGGAGGAGGAGGATTGCATCCA
GGTTAAGGACGAGGAGGGCGAGAGTGGTGCTGAGGAGGGGCCCGACTTGGAGGAGCCTGGTGCTGGATACAAAAAACTGTTCTCAGATGC
CCAGCCGCTGCAGCCTTTGCAGGTGTACCAGGCGCCCCTCAGCCTGGCCACTGTGCCCCACCAGGCCCTGGGCCGTACCCAGTCCTCCCC
TGCTGCCCCTGGGGGCATGAAGAGCCCCCCAGACCAGCCCGTCAAGCACCTCTTCACCACAGGCCCCATCAGCCAGAAGATGTATGCTGT
GCTGCCTTGTGGGGGCATCGGGGTGGACAGTGACACCGTGTGGAATGAGATGCACTCCTCCAGTGCTGTGCGCATGGCAGTGGGCTGCCT
GCTGGAGCTGGCCTTCAAGGTGGCTGCAGGAGAGCTCAAGAATGGATTTGCCATCATCCGGCCCCCAGGACACCACGCCGAGGAATCCAC
AGCCATGGGATTCTGCTTCTTCAACTCTGTAGCCATCACCGCAAAACTCCTACAGCAGAAGTTGAACGTGGGCAAGGTCCTCATCGTGGA
CTGGGACATTCACCATGGCAATGGCACCCAGCAGGCGTTCTACAATGACCCCTCTGTGCTCTACATCTCTCTGCATCGCTATGACAACGG
GAACTTCTTTCCAGGCTCTGGGGCTCCTGAAGAGGTTGGTGGAGGACCAGGCGTGGGGTACAATGTGAACGTGGCATGGACAGGAGGTGT
GGACCCCCCCATTGGAGACGTGGAGTACCTTACAGCCTTCAGGACAGTGGTGATGCCCATTGCCCACGAGTTCTCACCTGATGTGGTCCT
AGTCTCCGCCGGGTTTGATGCTGTTGAAGGACATCTGTCTCCTCTGGGTGGCTACTCTGTCACCGCCAGATGTTTTGGCCACTTGACCAG
GCAGCTGATGACCCTGGCAGGGGGCCGGGTGGTGCTGGCCCTGGAGGGAGGCCATGACTTGACCGCCATCTGTGATGCCTCTGAGGCTTG
TGTCTCGGCTCTGCTCAGTGTAGAGCTGCAGCCCTTGGATGAGGCAGTCTTGCAGCAAAAGCCCAACATCAACGCAGTGGCCACGCTAGA
GAAAGTCATCGAGATCCAGAGCAAACACTGGAGCTGTGTGCAGAAGTTCGCCGCTGGTCTGGGCCGGTCCCTGCGAGAGGCCCAAGCAGG
TGAGACCGAGGAGGCCGAGACTGTGAGCGCCATGGCCTTGCTGTCGGTGGGGGCCGAGCAGGCCCAGGCTGCGGCAGCCCGGGAACACAG
CCCCAGGCCGGCAGAGGAGCCCATGGAGCAGGAGCCTGCCCTGTGACGCCCCGGCCCCCATCCCTCTGGGCTTCACCATTGTGATTTTGT
TTATTTTTTCTATTAAAAACAAAAAGTCACACATTCAACAAGGTGTGCCGTGTGGGTCTCTCAGCCTTGCCCCTCCTGCTCCTCTACGCT
GCCTCAGGCCCCCAGCCCTGTGGCTTCCACCTCAGCTCTAGAAGCCTGCTCCCTCTGCAGGGGGTGGTGGTGTCTTCCCAGCCCTGTCCC
ATGTGTCCCTCCCCCCATTTTCCTGCATTCTGTCTGTCCTTTTCCTCCTTGGAGCCTGGGCCAGCTCAAGGTGGGCACGGGGGCCCAGAC
AGTACTCTCCAGTTCTGGGGCCCCCCGAGTGAGGAGGGAACGGGAAGTCGGTGCCTTGGTTTCAGCTGATTTGGGGGGAAATGCCTTAAT
TTCACTCTCCTCCCTTCTCCAGCCTCAGGGGAGGATCTGGAGGATCCACTACTGTCTTTAAGATGCAGAGTGGAGGGGAGGTGGGCACCC
ACCCTGCGATTCTCCACCCTTTCCCCTTCTTTCGTCCTCACCATCTCTGCAGACCCCTCTCCTCCTCCTTCCTCTTGGTCTCAGCACTGA
TGGGAGGCTGGTGCCCAAGCTGTGGCCTGCAGTCTGTGAGGAGGGCTGTCTTGCCTCACACTCCTCACAGCCTACTTCCCCTTCCCCGGG
GCTGAGAGGGTGAAAGTGTGTGGGGAAGGAGAGGACTGGTTTCCTGGGTTCTCAGGGGCCAGGAGGAGTAACAGAACCAGGTCTGCTCCC
CACCTTACTCGGATGGCCTCCCTGCCCCTCTGCTGGCACAGCCTGGGCAAGGGGAGAAGGTGGTCCCTGCAGAGGGGCTCCAGGCTGGTG
AGAGCCCCCCTGCTGTCAGGACCAGATTTTCCCAGCCATCCAGCATGCTGCGGGGAGAAGGGGCAGAGGCTCACCTCCCTCCTGGGGCCT
TTTGTTTTGGATCCTGGGGATGGTGAGAATGGAGGTTCTAGAAGGGGTAAGGCCAGAACCCAGGGATCCAGGAGTCGGCTCTCAGCTGGA
GCTTCCATACCTTCTGGGCTCCCTTTGCTGACCACCAGCCCAAGGGAGCTAAGACCAGGAGGGGGCTGGGCGCTGTCCCTTCTCTTTCCC
AGGAGCCCTGCCAGGGGCTGTGGGCCTACAAGGCTTCCAGGGGATGCCATCCAGCCTGTAGGAAACCAAAGATGGGAAGTGGCTCCTAGG
GGGCTGACTCTTCCTTCCTCCTCCTCCCCAGTACCACATATACTTTCTCTCCTTCTATCTCCAGGGCCCCACCAATCTGTTTACATATTT
ATTATCCTATGGGGGCCTGAGCAGGATTGAGGGAGCCAGGGGAGGGGCAGGAGTCCCAGCACCATCGGTTCATAGTGTGCTTGTGTGTTT
GTTTTAGATCCTCCTGGGGGATGGGGATGGGGCCAGGCTCAGTGTACTAGGCCTCTCTGTGCTGAGCCCCAGGCTCCCGGCCCCTTACCC
ACTCTCTCCCTGTGGCTGGTCTGGTTCTCATGTAAACCCACTCCTTGCTTTGTCTCCCTGGATATGGATTTCAGTTAAGTATTTTGTAAC

>2685_2685_2_AFF3-HDAC5_AFF3_chr2_100623094_ENST00000409236_HDAC5_chr17_42171202_ENST00000336057_length(amino acids)=1037AA_BP=31
MHIIQGSPCQQAGACQSQGQALQVQHPQAGGVEVKPVLPRAMPSSMGGGGGGSPSPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQ
KQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIAS
TEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLK
QKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPNQ
FSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLL
LEQARQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGE
LPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLF
SDAQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAV
GCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRY
DNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGH
LTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREA

--------------------------------------------------------------
>2685_2685_3_AFF3-HDAC5_AFF3_chr2_100623094_ENST00000409236_HDAC5_chr17_42171202_ENST00000393622_length(transcript)=5884nt_BP=986nt
GAGCTCGCTGCTCTCTCTTGAGTGTGCCTGCGCGCAAGCCGGGGAGCGGCGCGCGGGCGGCCCGAGCCTCGGCGGCGGCGGTAGCGGCGG
CGGCGACGCTGACACCTCCCACCATGGACAGCTTCGACTTAGCCCTGCTCCAGGAATGGGACCTCGAGTCACTGTGTGTCTATGAACCAG
ATAGAAATGCATTACGGAGGAAAGAACGAGAAAGAAGAAATCAAGAAACTCAACAGGATGATGGCACGTTTAATTCTAGTTACTCTCTCT
TCAGTGAGCCCTACAAGACTAACAAGGGGGATGAACTCTCCAACCGGATCCAGAACACTTTAGGCAATTATGATGAAATGAAAGACTTTT
TAACTGATAGATCCAATCAGAGTCATCTCGTTGGAGTTCCCAAACCTGGGGTTCCTCAGACTCCTGTGAACAAGATCGATGAACATTTTG
TTGCAGATTCAAGAGCCCAGAACCAGCCCTCGTCTATCTGTAGCACTACAACTTCCACACCAGCAGCTGTCCCCGTGCAGCAGAGTAAGA
GAGGCACTATGGGCTGGCAGAAGGCTGGGCACCCACCCTCTGACGGCCAACAGAGAGCAACACAACAGGGCTCTCTCAGGACCTTGCTTG
GAGATGGTGTTGGCAGACAGCAGCCTCGGGCCAAACAAGTGTGCAATGTGGAGGTGGGCCTTCAGACCCAGGAGAGGCCACCTGCCATGG
CGGCCAAGCACAGCAGCAGCGGACACTGTGTTCAGAACTTTCCTCCATCCCTAGCTTCAAAACCCAGCCTGGTCCAGCAGAAACCGACCG
CGTATGTGAGGCCAATGGACGGCCAAGATCAGGCCCCTGATGAGTCTCCTAAGCTGAAGTCGTCTTCGGAAACCAGCGTGCACTGCACAT
CATACAGGGGAGTCCCTGCCAGCAAGCCGGAGCCTGCCAGAGCCAAGGCCAAGCTCTCCAAGTTCAGCATCCCCAAGCAGGGGGAGTGGA
GGTGAAGCCGGTGCTGCCAAGAGCCATGCCCAGTTCCATGGGGGGTGGGGGTGGAGGCAGCCCCAGCCCTGTGGAGCTACGGGGGGCTCT
GGTGGGCTCTGTGGACCCCACACTGCGGGAGCAGCAACTGCAGCAGGAGCTCCTGGCGCTCAAGCAGCAGCAGCAGCTGCAGAAGCAGCT
CCTGTTCGCTGAGTTCCAGAAACAGCATGACCACCTGACAAGGCAGCATGAGGTCCAGCTGCAGAAGCACCTCAAGCAGCAGCAGGAGAT
GCTGGCAGCCAAGCAGCAGCAGGAGATGCTGGCAGCCAAGCGGCAGCAGGAGCTGGAGCAGCAGCGGCAGCGGGAGCAGCAGCGGCAGGA
AGAGCTGGAGAAGCAGCGGCTGGAGCAGCAGCTGCTCATCCTGCGGAACAAGGAGAAGAGCAAAGAGAGTGCCATTGCCAGCACTGAGGT
AAAGCTGAGGCTCCAGGAATTCCTCTTGTCGAAGTCAAAGGAGCCCACACCAGGCGGCCTCAACCATTCCCTCCCACAGCACCCCAAATG
CTGGGGAGCCCACCATGCTTCTTTGGACCAGAGTTCCCCTCCCCAGAGCGGCCCCCCTGGGACGCCTCCCTCCTACAAACTGCCTTTGCC
TGGGCCCTACGACAGTCGAGACGACTTCCCCCTCCGCAAAACAGCCTCTGAACCCAACTTGAAAGTGCGTTCAAGGCTAAAACAGAAGGT
GGCTGAGCGGAGAAGCAGTCCCCTCCTGCGTCGCAAGGATGGGACTGTTATTAGCACCTTTAAGAAGAGAGCTGTTGAGATCACAGGTGC
CGGGCCTGGGGCGTCGTCCGTGTGTAACAGCGCACCCGGCTCCGGCCCCAGCTCTCCCAACAGCTCCCACAGCACCATCGCTGAGAATGG
CTTTACTGGCTCAGTCCCCAACATCCCCACTGAGATGCTCCCTCAGCACCGAGCCCTCCCTCTGGACAGCTCCCCCAACCAGTTCAGCCT
CTACACGTCTCCTTCTCTGCCCAACATCTCCCTAGGGCTGCAGGCCACGGTCACTGTCACCAACTCACACCTCACTGCCTCCCCGAAGCT
GTCGACACAGCAGGAGGCCGAGAGGCAGGCCCTCCAGTCCCTGCGGCAGGGTGGCACGCTGACCGGCAAGTTCATGAGCACATCCTCTAT
TCCTGGCTGCCTGCTGGGCGTGGCACTGGAGGGCGACGGGAGCCCCCACGGGCATGCCTCCCTGCTGCAGCATGTGCTGTTGCTGGAGCA
GGCCCGGCAGCAGAGCACCCTCATTGCTGTGCCACTCCACGGGCAGTCCCCACTAGTGACGGGTGAACGTGTGGCCACCAGCATGCGGAC
GGTAGGCAAGCTCCCGCGGCATCGGCCCCTGAGCCGCACTCAGTCCTCACCGCTGCCGCAGAGTCCCCAGGCCCTGCAGCAGCTGGTCAT
GCAACAACAGCACCAGCAGTTCCTGGAGAAGCAGAAGCAGCAGCAGCTACAGCTGGGCAAGATCCTCACCAAGACAGGGGAGCTGCCCAG
GCAGCCCACCACCCACCCTGAGGAGACAGAGGAGGAGCTGACGGAGCAGCAGGAGGTCTTGCTGGGGGAGGGAGCCCTGACCATGCCCCG
GGAGGGCTCCACAGAGAGTGAGAGCACACAGGAAGACCTGGAGGAGGAGGACGAGGAAGACGATGGGGAGGAGGAGGAGGATTGCATCCA
GGTTAAGGACGAGGAGGGCGAGAGTGGTGCTGAGGAGGGGCCCGACTTGGAGGAGCCTGGTGCTGGATACAAAAAACTGTTCTCAGATGC
CCAGCCGCTGCAGCCTTTGCAGGTGTACCAGGCGCCCCTCAGCCTGGCCACTGTGCCCCACCAGGCCCTGGGCCGTACCCAGTCCTCCCC
TGCTGCCCCTGGGGGCATGAAGAGCCCCCCAGACCAGCCCGTCAAGCACCTCTTCACCACAGGTGTGGTCTACGACACGTTCATGCTAAA
GCACCAGTGCATGTGCGGGAACACACACGTGCACCCTGAGCATGCTGGCCGGATCCAGAGCATCTGGTCCCGGCTGCAGGAGACAGGCCT
GCTTAGCAAGTGCGAGCGGATCCGAGGTCGCAAAGCCACGCTAGATGAGATCCAGACAGTGCACTCTGAATACCACACCCTGCTCTATGG
GACCAGTCCCCTCAACCGGCAGAAGCTAGACAGCAAGAAGTTGCTCGGCCCCATCAGCCAGAAGATGTATGCTGTGCTGCCTTGTGGGGG
CATCGGGGTGGACAGTGACACCGTGTGGAATGAGATGCACTCCTCCAGTGCTGTGCGCATGGCAGTGGGCTGCCTGCTGGAGCTGGCCTT
CAAGGTGGCTGCAGGAGAGCTCAAGAATGGATTTGCCATCATCCGGCCCCCAGGACACCACGCCGAGGAATCCACAGCCATGGGATTCTG
CTTCTTCAACTCTGTAGCCATCACCGCAAAACTCCTACAGCAGAAGTTGAACGTGGGCAAGGTCCTCATCGTGGACTGGGACATTCACCA
TGGCAATGGCACCCAGCAGGCGTTCTACAATGACCCCTCTGTGCTCTACATCTCTCTGCATCGCTATGACAACGGGAACTTCTTTCCAGG
CTCTGGGGCTCCTGAAGAGGTTGGTGGAGGACCAGGCGTGGGGTACAATGTGAACGTGGCATGGACAGGAGGTGTGGACCCCCCCATTGG
AGACGTGGAGTACCTTACAGCCTTCAGGACAGTGGTGATGCCCATTGCCCACGAGTTCTCACCTGATGTGGTCCTAGTCTCCGCCGGGTT
TGATGCTGTTGAAGGACATCTGTCTCCTCTGGGTGGCTACTCTGTCACCGCCAGATGTTTTGGCCACTTGACCAGGCAGCTGATGACCCT
GGCAGGGGGCCGGGTGGTGCTGGCCCTGGAGGGAGGCCATGACTTGACCGCCATCTGTGATGCCTCTGAGGCTTGTGTCTCGGCTCTGCT
CAGTGTAGAGCTGCAGCCCTTGGATGAGGCAGTCTTGCAGCAAAAGCCCAACATCAACGCAGTGGCCACGCTAGAGAAAGTCATCGAGAT
CCAGAGCAAACACTGGAGCTGTGTGCAGAAGTTCGCCGCTGGTCTGGGCCGGTCCCTGCGAGAGGCCCAAGCAGGTGAGACCGAGGAGGC
CGAGACTGTGAGCGCCATGGCCTTGCTGTCGGTGGGGGCCGAGCAGGCCCAGGCTGCGGCAGCCCGGGAACACAGCCCCAGGCCGGCAGA
GGAGCCCATGGAGCAGGAGCCTGCCCTGTGACGCCCCGGCCCCCATCCCTCTGGGCTTCACCATTGTGATTTTGTTTATTTTTTCTATTA
AAAACAAAAAGTCACACATTCAACAAGGTGTGCCGTGTGGGTCTCTCAGCCTTGCCCCTCCTGCTCCTCTACGCTGCCTCAGGCCCCCAG
CCCTGTGGCTTCCACCTCAGCTCTAGAAGCCTGCTCCCTCTGCAGGGGGTGGTGGTGTCTTCCCAGCCCTGTCCCATGTGTCCCTCCCCC
CATTTTCCTGCATTCTGTCTGTCCTTTTCCTCCTTGGAGCCTGGGCCAGCTCAAGGTGGGCACGGGGGCCCAGACAGTACTCTCCAGTTC
TGGGGCCCCCCGAGTGAGGAGGGAACGGGAAGTCGGTGCCTTGGTTTCAGCTGATTTGGGGGGAAATGCCTTAATTTCACTCTCCTCCCT
TCTCCAGCCTCAGGGGAGGATCTGGAGGATCCACTACTGTCTTTAAGATGCAGAGTGGAGGGGAGGTGGGCACCCACCCTGCGATTCTCC
ACCCTTTCCCCTTCTTTCGTCCTCACCATCTCTGCAGACCCCTCTCCTCCTCCTTCCTCTTGGTCTCAGCACTGATGGGAGGCTGGTGCC
CAAGCTGTGGCCTGCAGTCTGTGAGGAGGGCTGTCTTGCCTCACACTCCTCACAGCCTACTTCCCCTTCCCCGGGGCTGAGAGGGTGAAA
GTGTGTGGGGAAGGAGAGGACTGGTTTCCTGGGTTCTCAGGGGCCAGGAGGAGTAACAGAACCAGGTCTGCTCCCCACCTTACTCGGATG
GCCTCCCTGCCCCTCTGCTGGCACAGCCTGGGCAAGGGGAGAAGGTGGTCCCTGCAGAGGGGCTCCAGGCTGGTGAGAGCCCCCCTGCTG
TCAGGACCAGATTTTCCCAGCCATCCAGCATGCTGCGGGGAGAAGGGGCAGAGGCTCACCTCCCTCCTGGGGCCTTTTGTTTTGGATCCT
GGGGATGGTGAGAATGGAGGTTCTAGAAGGGGTAAGGCCAGAACCCAGGGATCCAGGAGTCGGCTCTCAGCTGGAGCTTCCATACCTTCT
GGGCTCCCTTTGCTGACCACCAGCCCAAGGGAGCTAAGACCAGGAGGGGGCTGGGCGCTGTCCCTTCTCTTTCCCAGGAGCCCTGCCAGG
GGCTGTGGGCCTACAAGGCTTCCAGGGGATGCCATCCAGCCTGTAGGAAACCAAAGATGGGAAGTGGCTCCTAGGGGGCTGACTCTTCCT
TCCTCCTCCTCCCCAGTACCACATATACTTTCTCTCCTTCTATCTCCAGGGCCCCACCAATCTGTTTACATATTTATTATCCTATGGGGG
CCTGAGCAGGATTGAGGGAGCCAGGGGAGGGGCAGGAGTCCCAGCACCATCGGTTCATAGTGTGCTTGTGTGTTTGTTTTAGATCCTCCT
GGGGGATGGGGATGGGGCCAGGCTCAGTGTACTAGGCCTCTCTGTGCTGAGCCCCAGGCTCCCGGCCCCTTACCCACTCTCTCCCTGTGG
CTGGTCTGGTTCTCATGTAAACCCACTCCTTGCTTTGTCTCCCTGGATATGGATTTCAGTTAAGTATTTTGTAACCCGTTACACTGTGTG

>2685_2685_3_AFF3-HDAC5_AFF3_chr2_100623094_ENST00000409236_HDAC5_chr17_42171202_ENST00000393622_length(amino acids)=1122AA_BP=31
MHIIQGSPCQQAGACQSQGQALQVQHPQAGGVEVKPVLPRAMPSSMGGGGGGSPSPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQ
KQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIAS
TEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLK
QKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPNQ
FSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLL
LEQARQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGE
LPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLF
SDAQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQE
TGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLE
LAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNF
FPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQL
MTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGET

--------------------------------------------------------------
>2685_2685_4_AFF3-HDAC5_AFF3_chr2_100623094_ENST00000409236_HDAC5_chr17_42171202_ENST00000586802_length(transcript)=4343nt_BP=986nt
GAGCTCGCTGCTCTCTCTTGAGTGTGCCTGCGCGCAAGCCGGGGAGCGGCGCGCGGGCGGCCCGAGCCTCGGCGGCGGCGGTAGCGGCGG
CGGCGACGCTGACACCTCCCACCATGGACAGCTTCGACTTAGCCCTGCTCCAGGAATGGGACCTCGAGTCACTGTGTGTCTATGAACCAG
ATAGAAATGCATTACGGAGGAAAGAACGAGAAAGAAGAAATCAAGAAACTCAACAGGATGATGGCACGTTTAATTCTAGTTACTCTCTCT
TCAGTGAGCCCTACAAGACTAACAAGGGGGATGAACTCTCCAACCGGATCCAGAACACTTTAGGCAATTATGATGAAATGAAAGACTTTT
TAACTGATAGATCCAATCAGAGTCATCTCGTTGGAGTTCCCAAACCTGGGGTTCCTCAGACTCCTGTGAACAAGATCGATGAACATTTTG
TTGCAGATTCAAGAGCCCAGAACCAGCCCTCGTCTATCTGTAGCACTACAACTTCCACACCAGCAGCTGTCCCCGTGCAGCAGAGTAAGA
GAGGCACTATGGGCTGGCAGAAGGCTGGGCACCCACCCTCTGACGGCCAACAGAGAGCAACACAACAGGGCTCTCTCAGGACCTTGCTTG
GAGATGGTGTTGGCAGACAGCAGCCTCGGGCCAAACAAGTGTGCAATGTGGAGGTGGGCCTTCAGACCCAGGAGAGGCCACCTGCCATGG
CGGCCAAGCACAGCAGCAGCGGACACTGTGTTCAGAACTTTCCTCCATCCCTAGCTTCAAAACCCAGCCTGGTCCAGCAGAAACCGACCG
CGTATGTGAGGCCAATGGACGGCCAAGATCAGGCCCCTGATGAGTCTCCTAAGCTGAAGTCGTCTTCGGAAACCAGCGTGCACTGCACAT
CATACAGGGGAGTCCCTGCCAGCAAGCCGGAGCCTGCCAGAGCCAAGGCCAAGCTCTCCAAGTTCAGCATCCCCAAGCAGGGGGAGTGGA
GGTGAAGCCGGTGCTGCCAAGAGCCATGCCCAGTTCCATGGGGGGTGGGGGTGGAGGCAGCCCCAGCCCTGTGGAGCTACGGGGGGCTCT
GGTGGGCTCTGTGGACCCCACACTGCGGGAGCAGCAACTGCAGCAGGAGCTCCTGGCGCTCAAGCAGCAGCAGCAGCTGCAGAAGCAGCT
CCTGTTCGCTGAGTTCCAGAAACAGCATGACCACCTGACAAGGCAGCATGAGGTCCAGCTGCAGAAGCACCTCAAGCAGCAGCAGGAGAT
GCTGGCAGCCAAGCAGCAGCAGGAGATGCTGGCAGCCAAGCGGCAGCAGGAGCTGGAGCAGCAGCGGCAGCGGGAGCAGCAGCGGCAGGA
AGAGCTGGAGAAGCAGCGGCTGGAGCAGCAGCTGCTCATCCTGCGGAACAAGGAGAAGAGCAAAGAGAGTGCCATTGCCAGCACTGAGGT
AAAGCTGAGGCTCCAGGAATTCCTCTTGTCGAAGTCAAAGGAGCCCACACCAGGCGGCCTCAACCATTCCCTCCCACAGCACCCCAAATG
CTGGGGAGCCCACCATGCTTCTTTGGACCAGAGTTCCCCTCCCCAGAGCGGCCCCCCTGGGACGCCTCCCTCCTACAAACTGCCTTTGCC
TGGGCCCTACGACAGTCGAGACGACTTCCCCCTCCGCAAAACAGCCTCTGAACCCAACTTGAAAGTGCGTTCAAGGCTAAAACAGAAGGT
GGCTGAGCGGAGAAGCAGTCCCCTCCTGCGTCGCAAGGATGGGACTGTTATTAGCACCTTTAAGAAGAGAGCTGTTGAGATCACAGGTGC
CGGGCCTGGGGCGTCGTCCGTGTGTAACAGCGCACCCGGCTCCGGCCCCAGCTCTCCCAACAGCTCCCACAGCACCATCGCTGAGAATGG
CTTTACTGGCTCAGTCCCCAACATCCCCACTGAGATGCTCCCTCAGCACCGAGCCCTCCCTCTGGACAGCTCCCCCAACCAGTTCAGCCT
CTACACGTCTCCTTCTCTGCCCAACATCTCCCTAGGGCTGCAGGCCACGGTCACTGTCACCAACTCACACCTCACTGCCTCCCCGAAGCT
GTCGACACAGCAGGAGGCCGAGAGGCAGGCCCTCCAGTCCCTGCGGCAGGGTGGCACGCTGACCGGCAAGTTCATGAGCACATCCTCTAT
TCCTGGCTGCCTGCTGGGCGTGGCACTGGAGGGCGACGGGAGCCCCCACGGGCATGCCTCCCTGCTGCAGCATGTGCTGTTGCTGGAGCA
GGCCCGGCAGCAGAGCACCCTCATTGCTGTGCCACTCCACGGGCAGTCCCCACTAGTGACGGGTGAACGTGTGGCCACCAGCATGCGGAC
GGTAGGCAAGCTCCCGCGGCATCGGCCCCTGAGCCGCACTCAGTCCTCACCGCTGCCGCAGAGTCCCCAGGCCCTGCAGCAGCTGGTCAT
GCAACAACAGCACCAGCAGTTCCTGGAGAAGCAGAAGCAGCAGCAGCTACAGCTGGGCAAGATCCTCACCAAGACAGGGGAGCTGCCCAG
GCAGCCCACCACCCACCCTGAGGAGACAGAGGAGGAGCTGACGGAGCAGCAGGAGGTCTTGCTGGGGGAGGGAGCCCTGACCATGCCCCG
GGAGGGCTCCACAGAGAGTGAGAGCACACAGGAAGACCTGGAGGAGGAGGACGAGGAAGACGATGGGGAGGAGGAGGAGGATTGCATCCA
GGTTAAGGACGAGGAGGGCGAGAGTGGTGCTGAGGAGGGGCCCGACTTGGAGGAGCCTGGTGCTGGATACAAAAAACTGTTCTCAGATGC
CCAGCCGCTGCAGCCTTTGCAGGTGTACCAGGCGCCCCTCAGCCTGGCCACTGTGCCCCACCAGGCCCTGGGCCGTACCCAGTCCTCCCC
TGCTGCCCCTGGGGGCATGAAGAGCCCCCCAGACCAGCCCGTCAAGCACCTCTTCACCACAGGTGTGGTCTACGACACGTTCATGCTAAA
GCACCAGTGCATGTGCGGGAACACACACGTGCACCCTGAGCATGCTGGCCGGATCCAGAGCATCTGGTCCCGGCTGCAGGAGACAGGCCT
GCTTAGCAAGTGCGAGCGGATCCGAGGTCGCAAAGCCACGCTAGATGAGATCCAGACAGTGCACTCTGAATACCACACCCTGCTCTATGG
GACCAGTCCCCTCAACCGGCAGAAGCTAGACAGCAAGAAGTTGCTCGGCCCCATCAGCCAGAAGATGTATGCTGTGCTGCCTTGTGGGGG
CATCGGGGTGGACAGTGACACCGTGTGGAATGAGATGCACTCCTCCAGTGCTGTGCGCATGGCAGTGGGCTGCCTGCTGGAGCTGGCCTT
CAAGGTGGCTGCAGGAGAGCTCAAGAATGGATTTGCCATCATCCGGCCCCCAGGACACCACGCCGAGGAATCCACAGCCATGGGATTCTG
CTTCTTCAACTCTGTAGCCATCACCGCAAAACTCCTACAGCAGAAGTTGAACGTGGGCAAGGTCCTCATCGTGGACTGGGACATTCACCA
TGGCAATGGCACCCAGCAGGCGTTCTACAATGACCCCTCTGTGCTCTACATCTCTCTGCATCGCTATGACAACGGGAACTTCTTTCCAGG
CTCTGGGGCTCCTGAAGAGGTTGGTGGAGGACCAGGCGTGGGGTACAATGTGAACGTGGCATGGACAGGAGGTGTGGACCCCCCCATTGG
AGACGTGGAGTACCTTACAGCCTTCAGGACAGTGGTGATGCCCATTGCCCACGAGTTCTCACCTGATGTGGTCCTAGTCTCCGCCGGGTT
TGATGCTGTTGAAGGACATCTGTCTCCTCTGGGTGGCTACTCTGTCACCGCCAGATGTTTTGGCCACTTGACCAGGCAGCTGATGACCCT
GGCAGGGGGCCGGGTGGTGCTGGCCCTGGAGGGAGGCCATGACTTGACCGCCATCTGTGATGCCTCTGAGGCTTGTGTCTCGGCTCTGCT
CAGTGTAGAGCTGCAGCCCTTGGATGAGGCAGTCTTGCAGCAAAAGCCCAACATCAACGCAGTGGCCACGCTAGAGAAAGTCATCGAGAT
CCAGAGCAAACACTGGAGCTGTGTGCAGAAGTTCGCCGCTGGTCTGGGCCGGTCCCTGCGAGAGGCCCAAGCAGGTGAGACCGAGGAGGC
CGAGACTGTGAGCGCCATGGCCTTGCTGTCGGTGGGGGCCGAGCAGGCCCAGGCTGCGGCAGCCCGGGAACACAGCCCCAGGCCGGCAGA
GGAGCCCATGGAGCAGGAGCCTGCCCTGTGACGCCCCGGCCCCCATCCCTCTGGGCTTCACCATTGTGATTTTGTTTATTTTTTCTATTA

>2685_2685_4_AFF3-HDAC5_AFF3_chr2_100623094_ENST00000409236_HDAC5_chr17_42171202_ENST00000586802_length(amino acids)=1122AA_BP=31
MHIIQGSPCQQAGACQSQGQALQVQHPQAGGVEVKPVLPRAMPSSMGGGGGGSPSPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQ
KQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIAS
TEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLK
QKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPNQ
FSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLL
LEQARQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGE
LPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLF
SDAQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQE
TGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLE
LAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNF
FPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQL
MTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGET

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AFF3-HDAC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AFF3-HDAC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AFF3-HDAC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAFF3C0003873Rheumatoid Arthritis2CTD_human
HgeneAFF3C0013146Drug abuse1CTD_human
HgeneAFF3C0013170Drug habituation1CTD_human
HgeneAFF3C0013222Drug Use Disorders1CTD_human
HgeneAFF3C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneAFF3C0036572Seizures1GENOMICS_ENGLAND
HgeneAFF3C0038580Substance Dependence1CTD_human
HgeneAFF3C0038586Substance Use Disorders1CTD_human
HgeneAFF3C0236969Substance-Related Disorders1CTD_human
HgeneAFF3C0740858Substance abuse problem1CTD_human
HgeneAFF3C1510472Drug Dependence1CTD_human
HgeneAFF3C3714756Intellectual Disability1GENOMICS_ENGLAND
HgeneAFF3C4316881Prescription Drug Abuse1CTD_human
TgeneC0011570Mental Depression2PSYGENET
TgeneC0011581Depressive disorder2PSYGENET
TgeneC0001546Adjustment Disorders1CTD_human
TgeneC0005586Bipolar Disorder1CTD_human
TgeneC0005587Depression, Bipolar1CTD_human
TgeneC0009171Cocaine Abuse1CTD_human
TgeneC0011579Reactive depression1CTD_human
TgeneC0024713Manic Disorder1CTD_human
TgeneC0029456Osteoporosis1GENOMICS_ENGLAND
TgeneC0036421Systemic Scleroderma1CTD_human
TgeneC0041696Unipolar Depression1PSYGENET
TgeneC0236736Cocaine-Related Disorders1CTD_human
TgeneC0338831Manic1CTD_human
TgeneC0340543Familial primary pulmonary hypertension1CTD_human
TgeneC0600427Cocaine Dependence1CTD_human
TgeneC1269683Major Depressive Disorder1PSYGENET
TgeneC1522512Transient Situational Disturbance1CTD_human
TgeneC1969342PULMONARY HYPERTENSION, PRIMARY, DEXFENFLURAMINE-ASSOCIATED1CTD_human
TgeneC1969343Pulmonary Hypertension, Primary, Fenfluramine-Associated1CTD_human
TgeneC3203102Idiopathic pulmonary arterial hypertension1CTD_human
TgeneC3714844Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia1CTD_human
TgeneC4552070Pulmonary Hypertension, Primary, 11CTD_human