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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LCN2-ZNFX1 (FusionGDB2 ID:HG3934TG57169)

Fusion Gene Summary for LCN2-ZNFX1

check button Fusion gene summary
Fusion gene informationFusion gene name: LCN2-ZNFX1
Fusion gene ID: hg3934tg57169
HgeneTgene
Gene symbol

LCN2

ZNFX1

Gene ID

3934

57169

Gene namelipocalin 2zinc finger NFX1-type containing 1
Synonyms24p3|MSFI|NGAL|p25-
Cytomap('LCN2')('ZNFX1')

9q34.11

20q13.13

Type of geneprotein-codingprotein-coding
Descriptionneutrophil gelatinase-associated lipocalin25 kDa alpha-2-microglobulin-related subunit of MMP-9migration-stimulating factor inhibitoroncogene 24p3siderocalin LCN2NFX1-type zinc finger-containing protein 1
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000277480, ENST00000373013, 
ENST00000470902, ENST00000372998, 
ENST00000373017, ENST00000540948, 
Fusion gene scores* DoF score6 X 5 X 4=12031 X 9 X 16=4464
# samples 735
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(35/4464*10)=-3.67291019999686
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LCN2 [Title/Abstract] AND ZNFX1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLCN2(130915734)-ZNFX1(47863418), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLCN2

GO:0042742

defense response to bacterium

27780864

HgeneLCN2

GO:0097577

sequestering of iron ion

27780864



check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AA-A01P-01ALCN2chr9

130915734

-ZNFX1chr20

47863418

-
ChimerDB4LUSCTCGA-92-8065-01ALCN2chr9

130915734

-ZNFX1chr20

47863418

-


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Fusion Gene ORF analysis for LCN2-ZNFX1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000277480ENST00000371752LCN2chr9

130915734

-ZNFX1chr20

47863418

-
5CDS-3UTRENST00000277480ENST00000396105LCN2chr9

130915734

-ZNFX1chr20

47863418

-
5CDS-3UTRENST00000373013ENST00000371752LCN2chr9

130915734

-ZNFX1chr20

47863418

-
5CDS-3UTRENST00000373013ENST00000396105LCN2chr9

130915734

-ZNFX1chr20

47863418

-
5CDS-3UTRENST00000470902ENST00000371752LCN2chr9

130915734

-ZNFX1chr20

47863418

-
5CDS-3UTRENST00000470902ENST00000396105LCN2chr9

130915734

-ZNFX1chr20

47863418

-
5CDS-intronENST00000277480ENST00000371754LCN2chr9

130915734

-ZNFX1chr20

47863418

-
5CDS-intronENST00000277480ENST00000469991LCN2chr9

130915734

-ZNFX1chr20

47863418

-
5CDS-intronENST00000373013ENST00000371754LCN2chr9

130915734

-ZNFX1chr20

47863418

-
5CDS-intronENST00000373013ENST00000469991LCN2chr9

130915734

-ZNFX1chr20

47863418

-
5CDS-intronENST00000470902ENST00000371754LCN2chr9

130915734

-ZNFX1chr20

47863418

-
5CDS-intronENST00000470902ENST00000469991LCN2chr9

130915734

-ZNFX1chr20

47863418

-
intron-3UTRENST00000372998ENST00000371752LCN2chr9

130915734

-ZNFX1chr20

47863418

-
intron-3UTRENST00000372998ENST00000396105LCN2chr9

130915734

-ZNFX1chr20

47863418

-
intron-3UTRENST00000373017ENST00000371752LCN2chr9

130915734

-ZNFX1chr20

47863418

-
intron-3UTRENST00000373017ENST00000396105LCN2chr9

130915734

-ZNFX1chr20

47863418

-
intron-3UTRENST00000540948ENST00000371752LCN2chr9

130915734

-ZNFX1chr20

47863418

-
intron-3UTRENST00000540948ENST00000396105LCN2chr9

130915734

-ZNFX1chr20

47863418

-
intron-intronENST00000372998ENST00000371754LCN2chr9

130915734

-ZNFX1chr20

47863418

-
intron-intronENST00000372998ENST00000469991LCN2chr9

130915734

-ZNFX1chr20

47863418

-
intron-intronENST00000373017ENST00000371754LCN2chr9

130915734

-ZNFX1chr20

47863418

-
intron-intronENST00000373017ENST00000469991LCN2chr9

130915734

-ZNFX1chr20

47863418

-
intron-intronENST00000540948ENST00000371754LCN2chr9

130915734

-ZNFX1chr20

47863418

-
intron-intronENST00000540948ENST00000469991LCN2chr9

130915734

-ZNFX1chr20

47863418

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for LCN2-ZNFX1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for LCN2-ZNFX1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:130915734/:47863418)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for LCN2-ZNFX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for LCN2-ZNFX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LCN2-ZNFX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LCN2-ZNFX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLCN2C0022660Kidney Failure, Acute5CTD_human
HgeneLCN2C1565662Acute Kidney Insufficiency5CTD_human
HgeneLCN2C2609414Acute kidney injury5CTD_human
HgeneLCN2C0022658Kidney Diseases4CTD_human
HgeneLCN2C0019193Hepatitis, Toxic2CTD_human
HgeneLCN2C0023893Liver Cirrhosis, Experimental2CTD_human
HgeneLCN2C0860207Drug-Induced Liver Disease2CTD_human
HgeneLCN2C1262760Hepatitis, Drug-Induced2CTD_human
HgeneLCN2C3658290Drug-Induced Acute Liver Injury2CTD_human
HgeneLCN2C4277682Chemical and Drug Induced Liver Injury2CTD_human
HgeneLCN2C4279912Chemically-Induced Liver Toxicity2CTD_human
HgeneLCN2C0002875Cooley's anemia1CTD_human
HgeneLCN2C0003873Rheumatoid Arthritis1CTD_human
HgeneLCN2C0005283beta Thalassemia1CTD_human
HgeneLCN2C0006663Calcinosis1CTD_human
HgeneLCN2C0006826Malignant Neoplasms1CTD_human
HgeneLCN2C0007570Celiac Disease1CTD_human
HgeneLCN2C0011616Contact Dermatitis1CTD_human
HgeneLCN2C0013221Drug toxicity1CTD_human
HgeneLCN2C0018824Heart valve disease1CTD_human
HgeneLCN2C0019025Hemoglobin F Disease1CTD_human
HgeneLCN2C0019188Hepatitis, Animal1CTD_human
HgeneLCN2C0021368Inflammation1CTD_human
HgeneLCN2C0027627Neoplasm Metastasis1CTD_human
HgeneLCN2C0027651Neoplasms1CTD_human
HgeneLCN2C0035222Respiratory Distress Syndrome, Adult1CTD_human
HgeneLCN2C0036341Schizophrenia1PSYGENET
HgeneLCN2C0041755Adverse reaction to drug1CTD_human
HgeneLCN2C0085578Thalassemia Minor1CTD_human
HgeneLCN2C0086692Benign Neoplasm1CTD_human
HgeneLCN2C0162351Contact hypersensitivity1CTD_human
HgeneLCN2C0263628Tumoral calcinosis1CTD_human
HgeneLCN2C0271979Thalassemia Intermedia1CTD_human
HgeneLCN2C0403447Chronic Kidney Insufficiency1CTD_human
HgeneLCN2C0521174Microcalcification1CTD_human
HgeneLCN2C1561643Chronic Kidney Diseases1CTD_human