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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LGALS3-MEIS1 (FusionGDB2 ID:HG3958TG4211)

Fusion Gene Summary for LGALS3-MEIS1

check button Fusion gene summary
Fusion gene informationFusion gene name: LGALS3-MEIS1
Fusion gene ID: hg3958tg4211
HgeneTgene
Gene symbol

LGALS3

MEIS1

Gene ID

3958

4211

Gene namegalectin 3Meis homeobox 1
SynonymsCBP35|GAL3|GALBP|GALIG|L31|LGALS2|MAC2-
Cytomap('LGALS3')('MEIS1')

14q22.3

2p14

Type of geneprotein-codingprotein-coding
Descriptiongalectin-335 kDa lectinIgE-binding proteinMAC-2 antigenadvanced glycation end-product receptor 3carbohydrate-binding protein 35epididymis secretory sperm binding proteingalactose-specific lectin 3laminin-binding proteinlectin L-29lectin, galactohomeobox protein Meis1Meis1, myeloid ecotropic viral integration site 1 homologWUGSC:H_NH0444B04.1leukemogenic homolog protein
Modification date2020032220200313
UniProtAcc.

O00470

Ensembl transtripts involved in fusion geneENST00000254301, ENST00000553755, 
ENST00000554715, 
Fusion gene scores* DoF score18 X 6 X 8=86411 X 10 X 4=440
# samples 1813
** MAII scorelog2(18/864*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/440*10)=-1.7589919004962
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LGALS3 [Title/Abstract] AND MEIS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLGALS3(55609467)-MEIS1(66706316), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLGALS3

GO:0002548

monocyte chemotaxis

10925302

HgeneLGALS3

GO:0030593

neutrophil chemotaxis

10925302

HgeneLGALS3

GO:0031334

positive regulation of protein complex assembly

24846175

HgeneLGALS3

GO:0045806

negative regulation of endocytosis

19706535

HgeneLGALS3

GO:0048245

eosinophil chemotaxis

10925302

HgeneLGALS3

GO:0048246

macrophage chemotaxis

10925302

HgeneLGALS3

GO:0050918

positive chemotaxis

10925302

HgeneLGALS3

GO:0070232

regulation of T cell apoptotic process

8692888

HgeneLGALS3

GO:0071674

mononuclear cell migration

10925302

HgeneLGALS3

GO:0071677

positive regulation of mononuclear cell migration

10925302

HgeneLGALS3

GO:0090280

positive regulation of calcium ion import

10925302

HgeneLGALS3

GO:1903078

positive regulation of protein localization to plasma membrane

24846175

HgeneLGALS3

GO:2001200

positive regulation of dendritic cell differentiation

16116184

HgeneLGALS3

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

22761016



check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA304654LGALS3chr14

55609467

+MEIS1chr2

66706316

+


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Fusion Gene ORF analysis for LGALS3-MEIS1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000254301ENST00000272369LGALS3chr14

55609467

+MEIS1chr2

66706316

+
5CDS-intronENST00000254301ENST00000398506LGALS3chr14

55609467

+MEIS1chr2

66706316

+
5CDS-intronENST00000254301ENST00000407092LGALS3chr14

55609467

+MEIS1chr2

66706316

+
5CDS-intronENST00000254301ENST00000409517LGALS3chr14

55609467

+MEIS1chr2

66706316

+
5CDS-intronENST00000254301ENST00000444274LGALS3chr14

55609467

+MEIS1chr2

66706316

+
5CDS-intronENST00000254301ENST00000488550LGALS3chr14

55609467

+MEIS1chr2

66706316

+
5CDS-intronENST00000254301ENST00000495021LGALS3chr14

55609467

+MEIS1chr2

66706316

+
5CDS-intronENST00000254301ENST00000560281LGALS3chr14

55609467

+MEIS1chr2

66706316

+
5CDS-intronENST00000553755ENST00000272369LGALS3chr14

55609467

+MEIS1chr2

66706316

+
5CDS-intronENST00000553755ENST00000398506LGALS3chr14

55609467

+MEIS1chr2

66706316

+
5CDS-intronENST00000553755ENST00000407092LGALS3chr14

55609467

+MEIS1chr2

66706316

+
5CDS-intronENST00000553755ENST00000409517LGALS3chr14

55609467

+MEIS1chr2

66706316

+
5CDS-intronENST00000553755ENST00000444274LGALS3chr14

55609467

+MEIS1chr2

66706316

+
5CDS-intronENST00000553755ENST00000488550LGALS3chr14

55609467

+MEIS1chr2

66706316

+
5CDS-intronENST00000553755ENST00000495021LGALS3chr14

55609467

+MEIS1chr2

66706316

+
5CDS-intronENST00000553755ENST00000560281LGALS3chr14

55609467

+MEIS1chr2

66706316

+
5CDS-intronENST00000554715ENST00000272369LGALS3chr14

55609467

+MEIS1chr2

66706316

+
5CDS-intronENST00000554715ENST00000398506LGALS3chr14

55609467

+MEIS1chr2

66706316

+
5CDS-intronENST00000554715ENST00000407092LGALS3chr14

55609467

+MEIS1chr2

66706316

+
5CDS-intronENST00000554715ENST00000409517LGALS3chr14

55609467

+MEIS1chr2

66706316

+
5CDS-intronENST00000554715ENST00000444274LGALS3chr14

55609467

+MEIS1chr2

66706316

+
5CDS-intronENST00000554715ENST00000488550LGALS3chr14

55609467

+MEIS1chr2

66706316

+
5CDS-intronENST00000554715ENST00000495021LGALS3chr14

55609467

+MEIS1chr2

66706316

+
5CDS-intronENST00000554715ENST00000560281LGALS3chr14

55609467

+MEIS1chr2

66706316

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for LGALS3-MEIS1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for LGALS3-MEIS1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:55609467/:66706316)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MEIS1

O00470

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias. {ECO:0000269|PubMed:12609849}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for LGALS3-MEIS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for LGALS3-MEIS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LGALS3-MEIS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LGALS3-MEIS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLGALS3C0023893Liver Cirrhosis, Experimental2CTD_human
HgeneLGALS3C0000786Spontaneous abortion1CTD_human
HgeneLGALS3C0000822Abortion, Tubal1CTD_human
HgeneLGALS3C0007621Neoplastic Cell Transformation1CTD_human
HgeneLGALS3C0014859Esophageal Neoplasms1CTD_human
HgeneLGALS3C0016059Fibrosis1CTD_human
HgeneLGALS3C0019193Hepatitis, Toxic1CTD_human
HgeneLGALS3C0024623Malignant neoplasm of stomach1CTD_human
HgeneLGALS3C0025202melanoma1CTD_human
HgeneLGALS3C0027051Myocardial Infarction1CTD_human
HgeneLGALS3C0027540Necrosis1CTD_human
HgeneLGALS3C0027627Neoplasm Metastasis1CTD_human
HgeneLGALS3C0027697Nephritis1CTD_human
HgeneLGALS3C0038356Stomach Neoplasms1CTD_human
HgeneLGALS3C0042373Vascular Diseases1CTD_human
HgeneLGALS3C0546837Malignant neoplasm of esophagus1CTD_human
HgeneLGALS3C0860207Drug-Induced Liver Disease1CTD_human
HgeneLGALS3C1262760Hepatitis, Drug-Induced1CTD_human
HgeneLGALS3C1536220ST segment elevation myocardial infarction1CTD_human
HgeneLGALS3C1623038Cirrhosis1CTD_human
HgeneLGALS3C1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgeneLGALS3C3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneLGALS3C3830362Early Pregnancy Loss1CTD_human
HgeneLGALS3C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneLGALS3C4279912Chemically-Induced Liver Toxicity1CTD_human
HgeneLGALS3C4552766Miscarriage1CTD_human
TgeneC0035258Restless Legs Syndrome2CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0021603Sleep Initiation and Maintenance Disorders1CTD_human
TgeneC0033139Primary Insomnia1CTD_human
TgeneC0270541Rebound Insomnia1CTD_human
TgeneC0349255Nonorganic Insomnia1CTD_human
TgeneC0393759Transient Insomnia1CTD_human
TgeneC0541798Early Awakening1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC0751249Chronic Insomnia1CTD_human
TgeneC0751250Psychophysiological Insomnia1CTD_human
TgeneC0751251Secondary Insomnia1CTD_human
TgeneC0751252Sleep Initiation Dysfunction1CTD_human
TgeneC0917801Sleeplessness1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human