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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LMNA-IGFBP2 (FusionGDB2 ID:HG4000TG3485)

Fusion Gene Summary for LMNA-IGFBP2

check button Fusion gene summary
Fusion gene informationFusion gene name: LMNA-IGFBP2
Fusion gene ID: hg4000tg3485
HgeneTgene
Gene symbol

LMNA

IGFBP2

Gene ID

4000

3485

Gene namelamin A/Cinsulin like growth factor binding protein 2
SynonymsCDCD1|CDDC|CMD1A|CMT2B1|EMD2|FPL|FPLD|FPLD2|HGPS|IDC|LDP1|LFP|LGMD1B|LMN1|LMNC|LMNL1|MADA|PRO1IBP2|IGF-BP53
Cytomap('LMNA')('IGFBP2')

1q22

2q35

Type of geneprotein-codingprotein-coding
Descriptionlamin70 kDa laminepididymis secretory sperm binding proteinlamin A/C-like 1mandibuloacral dysplasia type Aprelamin-A/Crenal carcinoma antigen NY-REN-32insulin-like growth factor-binding protein 2IGF-binding protein 2insulin-like growth factor binding protein 2, 36kDa
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000347559, ENST00000368300, 
ENST00000368299, ENST00000361308, 
ENST00000368297, ENST00000368301, 
ENST00000392353, ENST00000448611, 
ENST00000473598, ENST00000496738, 
Fusion gene scores* DoF score16 X 16 X 9=23044 X 4 X 4=64
# samples 215
** MAII scorelog2(21/2304*10)=-3.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LMNA [Title/Abstract] AND IGFBP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLMNA(156109108)-IGFBP2(217525456), # samples:1
Anticipated loss of major functional domain due to fusion event.LMNA-IGFBP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LMNA-IGFBP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LMNA-IGFBP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LMNA-IGFBP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLMNA

GO:0090343

positive regulation of cell aging

20458013

TgeneIGFBP2

GO:0042104

positive regulation of activated T cell proliferation

15694994


check buttonFusion gene breakpoints across LMNA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across IGFBP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-EO-A3AY-01ALMNAchr1

156109108

-IGFBP2chr2

217525456

+


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Fusion Gene ORF analysis for LMNA-IGFBP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000347559ENST00000233809LMNAchr1

156109108

-IGFBP2chr2

217525456

+
3UTR-3CDSENST00000347559ENST00000456764LMNAchr1

156109108

-IGFBP2chr2

217525456

+
3UTR-3CDSENST00000368300ENST00000233809LMNAchr1

156109108

-IGFBP2chr2

217525456

+
3UTR-3CDSENST00000368300ENST00000456764LMNAchr1

156109108

-IGFBP2chr2

217525456

+
In-frameENST00000368299ENST00000233809LMNAchr1

156109108

-IGFBP2chr2

217525456

+
In-frameENST00000368299ENST00000456764LMNAchr1

156109108

-IGFBP2chr2

217525456

+
intron-3CDSENST00000361308ENST00000233809LMNAchr1

156109108

-IGFBP2chr2

217525456

+
intron-3CDSENST00000361308ENST00000456764LMNAchr1

156109108

-IGFBP2chr2

217525456

+
intron-3CDSENST00000368297ENST00000233809LMNAchr1

156109108

-IGFBP2chr2

217525456

+
intron-3CDSENST00000368297ENST00000456764LMNAchr1

156109108

-IGFBP2chr2

217525456

+
intron-3CDSENST00000368301ENST00000233809LMNAchr1

156109108

-IGFBP2chr2

217525456

+
intron-3CDSENST00000368301ENST00000456764LMNAchr1

156109108

-IGFBP2chr2

217525456

+
intron-3CDSENST00000392353ENST00000233809LMNAchr1

156109108

-IGFBP2chr2

217525456

+
intron-3CDSENST00000392353ENST00000456764LMNAchr1

156109108

-IGFBP2chr2

217525456

+
intron-3CDSENST00000448611ENST00000233809LMNAchr1

156109108

-IGFBP2chr2

217525456

+
intron-3CDSENST00000448611ENST00000456764LMNAchr1

156109108

-IGFBP2chr2

217525456

+
intron-3CDSENST00000473598ENST00000233809LMNAchr1

156109108

-IGFBP2chr2

217525456

+
intron-3CDSENST00000473598ENST00000456764LMNAchr1

156109108

-IGFBP2chr2

217525456

+
intron-3CDSENST00000496738ENST00000233809LMNAchr1

156109108

-IGFBP2chr2

217525456

+
intron-3CDSENST00000496738ENST00000456764LMNAchr1

156109108

-IGFBP2chr2

217525456

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000368299LMNAchr1156109108-ENST00000233809IGFBP2chr2217525456+29442253682041657
ENST00000368299LMNAchr1156109108-ENST00000456764IGFBP2chr2217525456+27932253682041657

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000368299ENST00000233809LMNAchr1156109108-IGFBP2chr2217525456+0.0204720370.97952795
ENST00000368299ENST00000456764LMNAchr1156109108-IGFBP2chr2217525456+0.0260492270.9739508

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Fusion Genomic Features for LMNA-IGFBP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for LMNA-IGFBP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:156109108/chr2:217525456)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneIGFBP2chr1:156109108chr2:217525456ENST0000023380904224_3060326.0DomainThyroglobulin type-1
TgeneIGFBP2chr1:156109108chr2:217525456ENST000002338090438_1340326.0DomainIGFBP N-terminal
TgeneIGFBP2chr1:156109108chr2:217525456ENST0000023380904301_3030326.0MotifNote=Cell attachment site

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLMNAchr1:156109108chr2:217525456ENST00000347559-11131_3870635.0DomainIF rod
HgeneLMNAchr1:156109108chr2:217525456ENST00000347559-111428_5450635.0DomainLTD
HgeneLMNAchr1:156109108chr2:217525456ENST00000361308-11031_3870573.0DomainIF rod
HgeneLMNAchr1:156109108chr2:217525456ENST00000361308-110428_5450573.0DomainLTD
HgeneLMNAchr1:156109108chr2:217525456ENST00000368300-11231_3870665.0DomainIF rod
HgeneLMNAchr1:156109108chr2:217525456ENST00000368300-112428_5450665.0DomainLTD
HgeneLMNAchr1:156109108chr2:217525456ENST00000368301-11331_3870573.0DomainIF rod
HgeneLMNAchr1:156109108chr2:217525456ENST00000368301-113428_5450573.0DomainLTD
HgeneLMNAchr1:156109108chr2:217525456ENST00000448611-11331_3870575.0DomainIF rod
HgeneLMNAchr1:156109108chr2:217525456ENST00000448611-113428_5450575.0DomainLTD
HgeneLMNAchr1:156109108chr2:217525456ENST00000347559-111417_4220635.0MotifNuclear localization signal
HgeneLMNAchr1:156109108chr2:217525456ENST00000361308-110417_4220573.0MotifNuclear localization signal
HgeneLMNAchr1:156109108chr2:217525456ENST00000368300-112417_4220665.0MotifNuclear localization signal
HgeneLMNAchr1:156109108chr2:217525456ENST00000368301-113417_4220573.0MotifNuclear localization signal
HgeneLMNAchr1:156109108chr2:217525456ENST00000448611-113417_4220575.0MotifNuclear localization signal
HgeneLMNAchr1:156109108chr2:217525456ENST00000347559-1111_330635.0RegionNote=Head
HgeneLMNAchr1:156109108chr2:217525456ENST00000347559-111219_2420635.0RegionNote=Linker 2
HgeneLMNAchr1:156109108chr2:217525456ENST00000347559-111243_3830635.0RegionNote=Coil 2
HgeneLMNAchr1:156109108chr2:217525456ENST00000347559-11134_700635.0RegionNote=Coil 1A
HgeneLMNAchr1:156109108chr2:217525456ENST00000347559-111384_6640635.0RegionNote=Tail
HgeneLMNAchr1:156109108chr2:217525456ENST00000347559-11171_800635.0RegionNote=Linker 1
HgeneLMNAchr1:156109108chr2:217525456ENST00000347559-11181_2180635.0RegionNote=Coil 1B
HgeneLMNAchr1:156109108chr2:217525456ENST00000361308-1101_330573.0RegionNote=Head
HgeneLMNAchr1:156109108chr2:217525456ENST00000361308-110219_2420573.0RegionNote=Linker 2
HgeneLMNAchr1:156109108chr2:217525456ENST00000361308-110243_3830573.0RegionNote=Coil 2
HgeneLMNAchr1:156109108chr2:217525456ENST00000361308-11034_700573.0RegionNote=Coil 1A
HgeneLMNAchr1:156109108chr2:217525456ENST00000361308-110384_6640573.0RegionNote=Tail
HgeneLMNAchr1:156109108chr2:217525456ENST00000361308-11071_800573.0RegionNote=Linker 1
HgeneLMNAchr1:156109108chr2:217525456ENST00000361308-11081_2180573.0RegionNote=Coil 1B
HgeneLMNAchr1:156109108chr2:217525456ENST00000368300-1121_330665.0RegionNote=Head
HgeneLMNAchr1:156109108chr2:217525456ENST00000368300-112219_2420665.0RegionNote=Linker 2
HgeneLMNAchr1:156109108chr2:217525456ENST00000368300-112243_3830665.0RegionNote=Coil 2
HgeneLMNAchr1:156109108chr2:217525456ENST00000368300-11234_700665.0RegionNote=Coil 1A
HgeneLMNAchr1:156109108chr2:217525456ENST00000368300-112384_6640665.0RegionNote=Tail
HgeneLMNAchr1:156109108chr2:217525456ENST00000368300-11271_800665.0RegionNote=Linker 1
HgeneLMNAchr1:156109108chr2:217525456ENST00000368300-11281_2180665.0RegionNote=Coil 1B
HgeneLMNAchr1:156109108chr2:217525456ENST00000368301-1131_330573.0RegionNote=Head
HgeneLMNAchr1:156109108chr2:217525456ENST00000368301-113219_2420573.0RegionNote=Linker 2
HgeneLMNAchr1:156109108chr2:217525456ENST00000368301-113243_3830573.0RegionNote=Coil 2
HgeneLMNAchr1:156109108chr2:217525456ENST00000368301-11334_700573.0RegionNote=Coil 1A
HgeneLMNAchr1:156109108chr2:217525456ENST00000368301-113384_6640573.0RegionNote=Tail
HgeneLMNAchr1:156109108chr2:217525456ENST00000368301-11371_800573.0RegionNote=Linker 1
HgeneLMNAchr1:156109108chr2:217525456ENST00000368301-11381_2180573.0RegionNote=Coil 1B
HgeneLMNAchr1:156109108chr2:217525456ENST00000448611-1131_330575.0RegionNote=Head
HgeneLMNAchr1:156109108chr2:217525456ENST00000448611-113219_2420575.0RegionNote=Linker 2
HgeneLMNAchr1:156109108chr2:217525456ENST00000448611-113243_3830575.0RegionNote=Coil 2
HgeneLMNAchr1:156109108chr2:217525456ENST00000448611-11334_700575.0RegionNote=Coil 1A
HgeneLMNAchr1:156109108chr2:217525456ENST00000448611-113384_6640575.0RegionNote=Tail
HgeneLMNAchr1:156109108chr2:217525456ENST00000448611-11371_800575.0RegionNote=Linker 1
HgeneLMNAchr1:156109108chr2:217525456ENST00000448611-11381_2180575.0RegionNote=Coil 1B


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Fusion Gene Sequence for LMNA-IGFBP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>45788_45788_1_LMNA-IGFBP2_LMNA_chr1_156109108_ENST00000368299_IGFBP2_chr2_217525456_ENST00000233809_length(transcript)=2944nt_BP=2253nt
GAGCGCCGCACCTACACCAGCCAACCCAGATCCCGAGGTCCGACAGCGCCCGGCCCAGATCCCCACGCCTGCCAGGAGCAAGCCGAGAGC
CAGCCGGCCGGCGCACTCCGACTCCGAGCAGTCTCTGTCCTTCGACCCGAGCCCCGCGCCCTTTCCGGGACCCCTGCCCCGCGGGCAGCG
CTGCCAACCTGCCGGCCATGGAGACCCCGTCCCAGCGGCGCGCCACCCGCAGCGGGGCGCAGGCCAGCTCCACTCCGCTGTCGCCCACCC
GCATCACCCGGCTGCAGGAGAAGGAGGACCTGCAGGAGCTCAATGATCGCTTGGCGGTCTACATCGACCGTGTGCGCTCGCTGGAAACGG
AGAACGCAGGGCTGCGCCTTCGCATCACCGAGTCTGAAGAGGTGGTCAGCCGCGAGGTGTCCGGCATCAAGGCCGCCTACGAGGCCGAGC
TCGGGGATGCCCGCAAGACCCTTGACTCAGTAGCCAAGGAGCGCGCCCGCCTGCAGCTGGAGCTGAGCAAAGTGCGTGAGGAGTTTAAGG
AGCTGAAAGCGCGCAATACCAAGAAGGAGGGTGACCTGATAGCTGCTCAGGCTCGGCTGAAGGACCTGGAGGCTCTGCTGAACTCCAAGG
AGGCCGCACTGAGCACTGCTCTCAGTGAGAAGCGCACGCTGGAGGGCGAGCTGCATGATCTGCGGGGCCAGGTGGCCAAGCTTGAGGCAG
CCCTAGGTGAGGCCAAGAAGCAACTTCAGGATGAGATGCTGCGGCGGGTGGATGCTGAGAACAGGCTGCAGACCATGAAGGAGGAACTGG
ACTTCCAGAAGAACATCTACAGTGAGGAGCTGCGTGAGACCAAGCGCCGTCATGAGACCCGACTGGTGGAGATTGACAATGGGAAGCAGC
GTGAGTTTGAGAGCCGGCTGGCGGATGCGCTGCAGGAACTGCGGGCCCAGCATGAGGACCAGGTGGAGCAGTATAAGAAGGAGCTGGAGA
AGACTTATTCTGCCAAGCTGGACAATGCCAGGCAGTCTGCTGAGAGGAACAGCAACCTGGTGGGGGCTGCCCACGAGGAGCTGCAGCAGT
CGCGCATCCGCATCGACAGCCTCTCTGCCCAGCTCAGCCAGCTCCAGAAGCAGCTGGCAGCCAAGGAGGCGAAGCTTCGAGACCTGGAGG
ACTCACTGGCCCGTGAGCGGGACACCAGCCGGCGGCTGCTGGCGGAAAAGGAGCGGGAGATGGCCGAGATGCGGGCAAGGATGCAGCAGC
AGCTGGACGAGTACCAGGAGCTTCTGGACATCAAGCTGGCCCTGGACATGGAGATCCACGCCTACCGCAAGCTCTTGGAGGGCGAGGAGG
AGAGGCTACGCCTGTCCCCCAGCCCTACCTCGCAGCGCAGCCGTGGCCGTGCTTCCTCTCACTCATCCCAGACACAGGGTGGGGGCAGCG
TCACCAAAAAGCGCAAACTGGAGTCCACTGAGAGCCGCAGCAGCTTCTCACAGCACGCACGCACTAGCGGGCGCGTGGCCGTGGAGGAGG
TGGATGAGGAGGGCAAGTTTGTCCGGCTGCGCAACAAGTCCAATGAGGACCAGTCCATGGGCAATTGGCAGATCAAGCGCCAGAATGGAG
ATGATCCCTTGCTGACTTACCGGTTCCCACCAAAGTTCACCCTGAAGGCTGGGCAGGTGGTGACGATCTGGGCTGCAGGAGCTGGGGCCA
CCCACAGCCCCCCTACCGACCTGGTGTGGAAGGCACAGAACACCTGGGGCTGCGGGAACAGCCTGCGTACGGCTCTCATCAACTCCACTG
GGGAAGAAGTGGCCATGCGCAAGCTGGTGCGCTCAGTGACTGTGGTTGAGGACGACGAGGATGAGGATGGAGATGACCTGCTCCATCACC
ACCACGGCTCCCACTGCAGCAGCTCGGGGGACCCCGCTGAGTACAACCTGCGCTCGCGCACCGTGCTGTGCGGGACCTGCGGGCAGCCTG
CCGACAAGGCATCTGCCAGCGGCTCAGGAGCCCAGAGCCCCCAGAACTGCAGCATCATGTAATCTGGGACCTGCCAGGCAGGGGTGGGGG
TGGAGGCTTCCTGCGTCCTCCTCACCTCATGCCCACCCCCTGCCCTGCACGTCATGGGAGGGGGCTTGAAGCCAAAGAAAAATAACCCTT
TGGTTTTTTTCTTCTGTATTTTTTTTTCTAAGAGAAGTTATTTTCTACAGTGGTTTTATACTGAAGGAAAAACACAAGCAAAAAAAAAAA
AAAAGCATCACCTTGGCCTGGAGGAGCCCAAGAAGCTGCGACCACCCCCTGCCAGGACTCCCTGCCAACAGGAACTGGACCAGGTCCTGG
AGCGGATCTCCACCATGCGCCTTCCGGATGAGCGGGGCCCTCTGGAGCACCTCTACTCCCTGCACATCCCCAACTGTGACAAGCATGGCC
TGTACAACCTCAAACAGTGCAAGATGTCTCTGAACGGGCAGCGTGGGGAGTGCTGGTGTGTGAACCCCAACACCGGGAAGCTGATCCAGG
GAGCCCCCACCATCCGGGGGGACCCCGAGTGTCATCTCTTCTACAATGAGCAGCAGGAGGCTCGCGGGGTGCACACCCAGCGGATGCAGT
AGACCGCAGCCAGCCGGTGCCTGGCGCCCCTGCCCCCCGCCCCTCTCCAAACACCGGCAGAAAACGGAGAGTGCTTGGGTGGTGGGTGCT
GGAGGATTTTCCAGTTCTGACACACGTATTTATATTTGGAAAGAGACCAGCACCGAGCTCGGCACCTCCCCGGCCTCTCTCTTCCCAGCT
GCAGATGCCACACCTGCTCCTTCTTGCTTTCCCCGGGGGAGGAAGGGGGTTGTGGTCGGGGAGCTGGGGTACAGGTTTGGGGAGGGGGAA

>45788_45788_1_LMNA-IGFBP2_LMNA_chr1_156109108_ENST00000368299_IGFBP2_chr2_217525456_ENST00000233809_length(amino acids)=657AA_BP=
MPGASREPAGRRTPTPSSLCPSTRAPRPFRDPCPAGSAANLPAMETPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYID
RVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDL
EALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLV
EIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKE
AKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSS
QTQGGGSVTKKRKLESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTI
WAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVL

--------------------------------------------------------------
>45788_45788_2_LMNA-IGFBP2_LMNA_chr1_156109108_ENST00000368299_IGFBP2_chr2_217525456_ENST00000456764_length(transcript)=2793nt_BP=2253nt
GAGCGCCGCACCTACACCAGCCAACCCAGATCCCGAGGTCCGACAGCGCCCGGCCCAGATCCCCACGCCTGCCAGGAGCAAGCCGAGAGC
CAGCCGGCCGGCGCACTCCGACTCCGAGCAGTCTCTGTCCTTCGACCCGAGCCCCGCGCCCTTTCCGGGACCCCTGCCCCGCGGGCAGCG
CTGCCAACCTGCCGGCCATGGAGACCCCGTCCCAGCGGCGCGCCACCCGCAGCGGGGCGCAGGCCAGCTCCACTCCGCTGTCGCCCACCC
GCATCACCCGGCTGCAGGAGAAGGAGGACCTGCAGGAGCTCAATGATCGCTTGGCGGTCTACATCGACCGTGTGCGCTCGCTGGAAACGG
AGAACGCAGGGCTGCGCCTTCGCATCACCGAGTCTGAAGAGGTGGTCAGCCGCGAGGTGTCCGGCATCAAGGCCGCCTACGAGGCCGAGC
TCGGGGATGCCCGCAAGACCCTTGACTCAGTAGCCAAGGAGCGCGCCCGCCTGCAGCTGGAGCTGAGCAAAGTGCGTGAGGAGTTTAAGG
AGCTGAAAGCGCGCAATACCAAGAAGGAGGGTGACCTGATAGCTGCTCAGGCTCGGCTGAAGGACCTGGAGGCTCTGCTGAACTCCAAGG
AGGCCGCACTGAGCACTGCTCTCAGTGAGAAGCGCACGCTGGAGGGCGAGCTGCATGATCTGCGGGGCCAGGTGGCCAAGCTTGAGGCAG
CCCTAGGTGAGGCCAAGAAGCAACTTCAGGATGAGATGCTGCGGCGGGTGGATGCTGAGAACAGGCTGCAGACCATGAAGGAGGAACTGG
ACTTCCAGAAGAACATCTACAGTGAGGAGCTGCGTGAGACCAAGCGCCGTCATGAGACCCGACTGGTGGAGATTGACAATGGGAAGCAGC
GTGAGTTTGAGAGCCGGCTGGCGGATGCGCTGCAGGAACTGCGGGCCCAGCATGAGGACCAGGTGGAGCAGTATAAGAAGGAGCTGGAGA
AGACTTATTCTGCCAAGCTGGACAATGCCAGGCAGTCTGCTGAGAGGAACAGCAACCTGGTGGGGGCTGCCCACGAGGAGCTGCAGCAGT
CGCGCATCCGCATCGACAGCCTCTCTGCCCAGCTCAGCCAGCTCCAGAAGCAGCTGGCAGCCAAGGAGGCGAAGCTTCGAGACCTGGAGG
ACTCACTGGCCCGTGAGCGGGACACCAGCCGGCGGCTGCTGGCGGAAAAGGAGCGGGAGATGGCCGAGATGCGGGCAAGGATGCAGCAGC
AGCTGGACGAGTACCAGGAGCTTCTGGACATCAAGCTGGCCCTGGACATGGAGATCCACGCCTACCGCAAGCTCTTGGAGGGCGAGGAGG
AGAGGCTACGCCTGTCCCCCAGCCCTACCTCGCAGCGCAGCCGTGGCCGTGCTTCCTCTCACTCATCCCAGACACAGGGTGGGGGCAGCG
TCACCAAAAAGCGCAAACTGGAGTCCACTGAGAGCCGCAGCAGCTTCTCACAGCACGCACGCACTAGCGGGCGCGTGGCCGTGGAGGAGG
TGGATGAGGAGGGCAAGTTTGTCCGGCTGCGCAACAAGTCCAATGAGGACCAGTCCATGGGCAATTGGCAGATCAAGCGCCAGAATGGAG
ATGATCCCTTGCTGACTTACCGGTTCCCACCAAAGTTCACCCTGAAGGCTGGGCAGGTGGTGACGATCTGGGCTGCAGGAGCTGGGGCCA
CCCACAGCCCCCCTACCGACCTGGTGTGGAAGGCACAGAACACCTGGGGCTGCGGGAACAGCCTGCGTACGGCTCTCATCAACTCCACTG
GGGAAGAAGTGGCCATGCGCAAGCTGGTGCGCTCAGTGACTGTGGTTGAGGACGACGAGGATGAGGATGGAGATGACCTGCTCCATCACC
ACCACGGCTCCCACTGCAGCAGCTCGGGGGACCCCGCTGAGTACAACCTGCGCTCGCGCACCGTGCTGTGCGGGACCTGCGGGCAGCCTG
CCGACAAGGCATCTGCCAGCGGCTCAGGAGCCCAGAGCCCCCAGAACTGCAGCATCATGTAATCTGGGACCTGCCAGGCAGGGGTGGGGG
TGGAGGCTTCCTGCGTCCTCCTCACCTCATGCCCACCCCCTGCCCTGCACGTCATGGGAGGGGGCTTGAAGCCAAAGAAAAATAACCCTT
TGGTTTTTTTCTTCTGTATTTTTTTTTCTAAGAGAAGTTATTTTCTACAGTGGTTTTATACTGAAGGAAAAACACAAGCAAAAAAAAAAA
AAAAGCATCACCTTGGCCTGGAGGAGCCCAAGAAGCTGCGACCACCCCCTGCCAGGACTCCCTGCCAACAGGAACTGGACCAGGTCCTGG
AGCGGATCTCCACCATGCGCCTTCCGGATGAGCGGGGCCCTCTGGAGCACCTCTACTCCCTGCACATCCCCAACTGTGACAAGCATGGCC
TGTACAACCTCAAACAGTGCAAGATGTCTCTGAACGGGCAGCGTGGGGAGTGCTGGTGTGTGAACCCCAACACCGGGAAGCTGATCCAGG
GAGCCCCCACCATCCGGGGGGACCCCGAGTGTCATCTCTTCTACAATGAGCAGCAGGAGGCTCGCGGGGTGCACACCCAGCGGATGCAGT
AGACCGCAGCCAGCCGGTGCCTGGCGCCCCTGCCCCCCGCCCCTCTCCAAACACCGGCAGAAAACGGAGAGTGCTTGGGTGGTGGGTGCT
GGAGGATTTTCCAGTTCTGACACACGTATTTATATTTGGAAAGAGACCAGCACCGAGCTCGGCACCTCCCCGGCCTCTCTCTTCCCAGCT

>45788_45788_2_LMNA-IGFBP2_LMNA_chr1_156109108_ENST00000368299_IGFBP2_chr2_217525456_ENST00000456764_length(amino acids)=657AA_BP=
MPGASREPAGRRTPTPSSLCPSTRAPRPFRDPCPAGSAANLPAMETPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYID
RVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDL
EALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLV
EIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKE
AKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSS
QTQGGGSVTKKRKLESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTI
WAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LMNA-IGFBP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneLMNAchr1:156109108chr2:217525456ENST00000347559-1111_1300635.0MLIP
HgeneLMNAchr1:156109108chr2:217525456ENST00000361308-1101_1300573.0MLIP
HgeneLMNAchr1:156109108chr2:217525456ENST00000368300-1121_1300665.0MLIP
HgeneLMNAchr1:156109108chr2:217525456ENST00000368301-1131_1300573.0MLIP
HgeneLMNAchr1:156109108chr2:217525456ENST00000448611-1131_1300575.0MLIP


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LMNA-IGFBP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LMNA-IGFBP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLMNAC1449563Cardiomyopathy, Familial Idiopathic24CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneLMNAC1720860Familial Partial Lipodystrophy, Type 219CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneLMNAC0033300Progeria16CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneLMNAC0410190Autosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)10CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneLMNAC0432291Mandibuloacral dysostosis9CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneLMNAC1720859Familial Partial Lipodystrophy, Type 16CTD_human;ORPHANET
HgeneLMNAC0271694Familial partial lipodystrophy5CTD_human;GENOMICS_ENGLAND
HgeneLMNAC0406585Lethal tight skin contracture syndrome (disorder)5CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneLMNAC0796031Malouf syndrome5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneLMNAC0007193Cardiomyopathy, Dilated4CTD_human
HgeneLMNAC1720861Familial Partial Lipodystrophy, Type 34CTD_human
HgeneLMNAC2750035Emery-Dreifuss Muscular Dystrophy 34GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneLMNAC2750785MUSCULAR DYSTROPHY, CONGENITAL, LMNA-RELATED (disorder)4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneLMNAC0410189Muscular Dystrophy, Emery-Dreifuss3CTD_human
HgeneLMNAC0686353Muscular Dystrophies, Limb-Girdle3CTD_human;GENOMICS_ENGLAND
HgeneLMNAC0751337X-Linked Emery-Dreifuss Muscular Dystrophy3CTD_human
HgeneLMNAC1450051Autosomal Recessive Emery-Dreifuss Muscular Dystrophy3CTD_human;ORPHANET
HgeneLMNAC1854154Charcot-Marie-Tooth disease, Type 2B13CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneLMNAC1857829Heart-hand syndrome, Slovenian type3CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneLMNAC1832931ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 22ORPHANET
HgeneLMNAC4275075Atypical Werner syndrome2ORPHANET
HgeneLMNAC0004245Atrioventricular Block1CTD_human
HgeneLMNAC0004331Auriculo-Ventricular Dissociation1CTD_human
HgeneLMNAC0011644Scleroderma1CTD_human
HgeneLMNAC0016508Congenital Foot Deformity1CTD_human
HgeneLMNAC0017668Focal glomerulosclerosis1GENOMICS_ENGLAND
HgeneLMNAC0018566Congenital Hand Deformities1CTD_human
HgeneLMNAC0018794Heart Block1CTD_human
HgeneLMNAC0032460Polycystic Ovary Syndrome1CTD_human
HgeneLMNAC0036420Localized scleroderma1CTD_human
HgeneLMNAC0037188Sinoatrial Block1CTD_human
HgeneLMNAC0042514Tachycardia, Ventricular1CTD_human
HgeneLMNAC0085298Sudden Cardiac Death1CTD_human
HgeneLMNAC0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneLMNAC0263409Linear Scleroderma1CTD_human
HgeneLMNAC0376634Craniofacial Abnormalities1CTD_human
HgeneLMNAC0546264Congenital Fiber Type Disproportion1GENOMICS_ENGLAND
HgeneLMNAC0796083Najjar syndrome1ORPHANET
HgeneLMNAC1136321HIV-Associated Lipodystrophy Syndrome1CTD_human
HgeneLMNAC1136382Sclerocystic Ovaries1CTD_human
HgeneLMNAC1527383Morphea1CTD_human
HgeneLMNAC1720824Sudden Cardiac Arrest1CTD_human
HgeneLMNAC4049702Focal Segmental Glomerulosclerosis, Not Otherwise Specified1GENOMICS_ENGLAND
HgeneLMNAC4750858LMNA-related cardiocutaneous progeria syndrome1ORPHANET
TgeneC0005586Bipolar Disorder3PSYGENET
TgeneC0023893Liver Cirrhosis, Experimental2CTD_human
TgeneC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneC0011616Contact Dermatitis1CTD_human
TgeneC0021655Insulin Resistance1CTD_human
TgeneC0023890Liver Cirrhosis1CTD_human
TgeneC0028754Obesity1CTD_human
TgeneC0036095Salivary Gland Neoplasms1CTD_human
TgeneC0162351Contact hypersensitivity1CTD_human
TgeneC0220636Malignant neoplasm of salivary gland1CTD_human
TgeneC0239946Fibrosis, Liver1CTD_human
TgeneC0920563Insulin Sensitivity1CTD_human