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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARNTL-DYNLRB1 (FusionGDB2 ID:HG406TG83658)

Fusion Gene Summary for ARNTL-DYNLRB1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARNTL-DYNLRB1
Fusion gene ID: hg406tg83658
HgeneTgene
Gene symbol

ARNTL

DYNLRB1

Gene ID

406

83658

Gene namearyl hydrocarbon receptor nuclear translocator likedynein light chain roadblock-type 1
SynonymsBMAL1|BMAL1c|JAP3|MOP3|PASD3|TIC|bHLHe5BITH|BLP|DNCL2A|DNLC2A|ROBLD1
Cytomap('ARNTL')('DYNLRB1')

11p15.3

20q11.22

Type of geneprotein-codingprotein-coding
Descriptionaryl hydrocarbon receptor nuclear translocator-like protein 1ARNT-like protein 1, brain and musclePAS domain containing 3PAS domain-containing protein 3bHLH-PAS protein JAP3basic helix-loop-helix family member e5basic-helix-loop-helix-PAS orphan MOPdynein light chain roadblock-type 1ROBL/LC7-like 1bithoraxoid-like proteindynein, cytoplasmic, light polypeptide 2Adynein-associated protein Km23roadblock domain-containing protein 1
Modification date2020032220200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000361003, ENST00000389707, 
ENST00000389708, ENST00000396441, 
ENST00000401424, ENST00000403290, 
ENST00000403510, ENST00000403482, 
ENST00000497429, 
Fusion gene scores* DoF score7 X 8 X 7=39217 X 12 X 12=2448
# samples 1023
** MAII scorelog2(10/392*10)=-1.97085365434048
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/2448*10)=-3.41189779174828
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARNTL [Title/Abstract] AND DYNLRB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARNTL(13331606)-DYNLRB1(33114073), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARNTL

GO:0032922

circadian regulation of gene expression

24005054

HgeneARNTL

GO:0045893

positive regulation of transcription, DNA-templated

11441146|12738229|23785138

HgeneARNTL

GO:0045944

positive regulation of transcription by RNA polymerase II

20093779

HgeneARNTL

GO:0051775

response to redox state

11441146



check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4PD-01AARNTLchr11

13331606

+DYNLRB1chr20

33114073

+


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Fusion Gene ORF analysis for ARNTL-DYNLRB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000361003ENST00000357156ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3CDSENST00000389707ENST00000357156ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3CDSENST00000389708ENST00000357156ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3CDSENST00000396441ENST00000357156ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3CDSENST00000401424ENST00000357156ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3CDSENST00000403290ENST00000357156ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3CDSENST00000403510ENST00000357156ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000361003ENST00000300469ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000361003ENST00000374846ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000361003ENST00000417166ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000361003ENST00000480759ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000389707ENST00000300469ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000389707ENST00000374846ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000389707ENST00000417166ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000389707ENST00000480759ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000389708ENST00000300469ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000389708ENST00000374846ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000389708ENST00000417166ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000389708ENST00000480759ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000396441ENST00000300469ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000396441ENST00000374846ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000396441ENST00000417166ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000396441ENST00000480759ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000401424ENST00000300469ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000401424ENST00000374846ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000401424ENST00000417166ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000401424ENST00000480759ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000403290ENST00000300469ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000403290ENST00000374846ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000403290ENST00000417166ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000403290ENST00000480759ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000403510ENST00000300469ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000403510ENST00000374846ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000403510ENST00000417166ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000403510ENST00000480759ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
intron-3CDSENST00000403482ENST00000357156ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
intron-3CDSENST00000497429ENST00000357156ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
intron-3UTRENST00000403482ENST00000300469ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
intron-3UTRENST00000403482ENST00000374846ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
intron-3UTRENST00000403482ENST00000417166ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
intron-3UTRENST00000403482ENST00000480759ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
intron-3UTRENST00000497429ENST00000300469ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
intron-3UTRENST00000497429ENST00000374846ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
intron-3UTRENST00000497429ENST00000417166ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+
intron-3UTRENST00000497429ENST00000480759ARNTLchr11

13331606

+DYNLRB1chr20

33114073

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ARNTL-DYNLRB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARNTLchr1113331606+DYNLRB1chr2033114072+0.0002657220.9997342
ARNTLchr1113331606+DYNLRB1chr2033114072+0.0002657220.9997342


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARNTL-DYNLRB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:13331606/:33114073)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ARNTL-DYNLRB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ARNTL-DYNLRB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARNTL-DYNLRB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARNTL-DYNLRB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARNTLC0005586Bipolar Disorder5PSYGENET
HgeneARNTLC0011570Mental Depression3PSYGENET
HgeneARNTLC0011581Depressive disorder3PSYGENET
HgeneARNTLC0525045Mood Disorders2PSYGENET
HgeneARNTLC0000772Multiple congenital anomalies1CTD_human
HgeneARNTLC0021361Female infertility1CTD_human
HgeneARNTLC0023473Myeloid Leukemia, Chronic1CTD_human
HgeneARNTLC0038279Sterility, Postpartum1CTD_human
HgeneARNTLC0085159Seasonal Affective Disorder1PSYGENET
HgeneARNTLC0151744Myocardial Ischemia1CTD_human
HgeneARNTLC0268548Hyperargininemia1CTD_human
HgeneARNTLC0341869Subfertility, Female1CTD_human
HgeneARNTLC0917730Female sterility1CTD_human