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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAOA-CCDC132 (FusionGDB2 ID:HG4128TG55610)

Fusion Gene Summary for MAOA-CCDC132

check button Fusion gene summary
Fusion gene informationFusion gene name: MAOA-CCDC132
Fusion gene ID: hg4128tg55610
HgeneTgene
Gene symbol

MAOA

CCDC132

Gene ID

4128

55610

Gene namemonoamine oxidase AVPS50 subunit of EARP/GARPII complex
SynonymsBRNRS|MAO-ACCDC132|VPS54L
Cytomap('MAOA')('CCDC132')

Xp11.3

7q21.2-q21.3

Type of geneprotein-codingprotein-coding
Descriptionamine oxidase [flavin-containing] Amonoamine oxidase type AsyndetinEARP/GARPII complex subunit VPS50VPS50, EARP/GARPII complex subunitcoiled-coil domain containing 132coiled-coil domain-containing protein 132
Modification date2020032920200313
UniProtAcc

P21397

.
Ensembl transtripts involved in fusion geneENST00000497485, ENST00000338702, 
ENST00000542639, 
Fusion gene scores* DoF score3 X 3 X 2=188 X 9 X 6=432
# samples 310
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(10/432*10)=-2.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAOA [Title/Abstract] AND CCDC132 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAOA(43552675)-CCDC132(92905477), # samples:1
Anticipated loss of major functional domain due to fusion event.MAOA-CCDC132 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MAOA-CCDC132 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCCDC132

GO:0032456

endocytic recycling

25799061


check buttonFusion gene breakpoints across MAOA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CCDC132 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-5799-01AMAOAchrX

43552675

+CCDC132chr7

92905477

+


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Fusion Gene ORF analysis for MAOA-CCDC132

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000497485ENST00000305866MAOAchrX

43552675

+CCDC132chr7

92905477

+
3UTR-3CDSENST00000497485ENST00000541136MAOAchrX

43552675

+CCDC132chr7

92905477

+
3UTR-3CDSENST00000497485ENST00000544910MAOAchrX

43552675

+CCDC132chr7

92905477

+
3UTR-5UTRENST00000497485ENST00000251739MAOAchrX

43552675

+CCDC132chr7

92905477

+
3UTR-5UTRENST00000497485ENST00000317751MAOAchrX

43552675

+CCDC132chr7

92905477

+
3UTR-intronENST00000497485ENST00000474412MAOAchrX

43552675

+CCDC132chr7

92905477

+
3UTR-intronENST00000497485ENST00000535481MAOAchrX

43552675

+CCDC132chr7

92905477

+
5CDS-5UTRENST00000338702ENST00000251739MAOAchrX

43552675

+CCDC132chr7

92905477

+
5CDS-5UTRENST00000338702ENST00000317751MAOAchrX

43552675

+CCDC132chr7

92905477

+
5CDS-intronENST00000338702ENST00000474412MAOAchrX

43552675

+CCDC132chr7

92905477

+
5CDS-intronENST00000338702ENST00000535481MAOAchrX

43552675

+CCDC132chr7

92905477

+
5UTR-3CDSENST00000542639ENST00000305866MAOAchrX

43552675

+CCDC132chr7

92905477

+
5UTR-3CDSENST00000542639ENST00000541136MAOAchrX

43552675

+CCDC132chr7

92905477

+
5UTR-3CDSENST00000542639ENST00000544910MAOAchrX

43552675

+CCDC132chr7

92905477

+
5UTR-5UTRENST00000542639ENST00000251739MAOAchrX

43552675

+CCDC132chr7

92905477

+
5UTR-5UTRENST00000542639ENST00000317751MAOAchrX

43552675

+CCDC132chr7

92905477

+
5UTR-intronENST00000542639ENST00000474412MAOAchrX

43552675

+CCDC132chr7

92905477

+
5UTR-intronENST00000542639ENST00000535481MAOAchrX

43552675

+CCDC132chr7

92905477

+
In-frameENST00000338702ENST00000305866MAOAchrX

43552675

+CCDC132chr7

92905477

+
In-frameENST00000338702ENST00000541136MAOAchrX

43552675

+CCDC132chr7

92905477

+
In-frameENST00000338702ENST00000544910MAOAchrX

43552675

+CCDC132chr7

92905477

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000338702MAOAchrX43552675+ENST00000305866CCDC132chr792905477+3113429482522824
ENST00000338702MAOAchrX43552675+ENST00000541136CCDC132chr792905477+3107429481976642
ENST00000338702MAOAchrX43552675+ENST00000544910CCDC132chr792905477+3112429482522824

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000338702ENST00000305866MAOAchrX43552675+CCDC132chr792905477+0.0003756460.9996244
ENST00000338702ENST00000541136MAOAchrX43552675+CCDC132chr792905477+0.0003422430.99965775
ENST00000338702ENST00000544910MAOAchrX43552675+CCDC132chr792905477+0.000377370.9996226

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Fusion Genomic Features for MAOA-CCDC132


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MAOA-CCDC132


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:43552675/chr7:92905477)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAOA

P21397

.
FUNCTION: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAOAchrX:43552675chr7:92905477ENST00000338702+3151_497102528.0Topological domainCytoplasmic
HgeneMAOAchrX:43552675chr7:92905477ENST00000338702+315519_527102528.0Topological domainMitochondrial intermembrane
HgeneMAOAchrX:43552675chr7:92905477ENST00000542639+4161_4970395.0Topological domainCytoplasmic
HgeneMAOAchrX:43552675chr7:92905477ENST00000542639+416519_5270395.0Topological domainMitochondrial intermembrane
HgeneMAOAchrX:43552675chr7:92905477ENST00000338702+315498_518102528.0TransmembraneNote=Helical%3B Anchor for type IV membrane protein
HgeneMAOAchrX:43552675chr7:92905477ENST00000542639+416498_5180395.0TransmembraneNote=Helical%3B Anchor for type IV membrane protein
TgeneCCDC132chrX:43552675chr7:92905477ENST000002517391012216_244267328.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC132chrX:43552675chr7:92905477ENST00000251739101282_105267328.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC132chrX:43552675chr7:92905477ENST000003058661028216_244267965.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC132chrX:43552675chr7:92905477ENST00000305866102882_105267965.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC132chrX:43552675chr7:92905477ENST000005449101129216_244237935.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC132chrX:43552675chr7:92905477ENST00000544910112982_105237935.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for MAOA-CCDC132


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>51138_51138_1_MAOA-CCDC132_MAOA_chrX_43552675_ENST00000338702_CCDC132_chr7_92905477_ENST00000305866_length(transcript)=3113nt_BP=429nt
CGGGTATCAAAAGAAGGATCGGCTCCGCCCCCGGGCTCCCCGGGGGAGTTGATAGAAGGGTCCTTCCCACCCTTTGCCGTCCCCACTCCT
GTGCCTACGACCCAGGAGCGTGTCAGCCAAAGCATGGAGAATCAAGAGAAGGCGAGTATCGCGGGCCACATGTTCGACGTAGTCGTGATC
GGAGGTGGCATTTCAGGACTATCTGCTGCCAAACTCTTGACTGAATATGGCGTTAGTGTTTTGGTTTTAGAAGCTCGGGACAGGGTTGGA
GGAAGAACATATACTATAAGGAATGAGCATGTTGATTACGTAGATGTTGGTGGAGCTTATGTGGGACCAACCCAAAACAGAATCTTACGC
TTGTCTAAGGAGCTGGGCATAGAGACTTACAAAGTGAATGTCAGTGAGCGTCTCGTTCAATATGTCAAGACAGCAATGGATCAACTTCAT
ATGCACTTCACCCAAGCCATTCACAACACCGTGTTTCAAGTTGTTCTTGGTTATGTGGAACTATGTGCAGGAAACACAGACACAAAATTC
CAAAAGCTGCAATATAAGGATCTCTGTACACATGTTACACCAGACAGCTATATTCCATGCCTTGCAGACCTGTGCAAAGCACTATGGGAA
GTTATGCTCAGCTATTATAGGACTATGGAATGGCATGAAAAGCATGACAATGAGGATACTGCTTCAGCTTCTGAAGGGAGTAATATGATA
GGTACTGAAGAAACTAATTTTGATCGTGGCTACATAAAAAAGAAATTAGAACATGGACTTACACGAATATGGCAGGATGTTCAGCTAAAA
GTAAAAACCTACTTGCTTGGAACTGATTTGTCTATATTCAAATATGATGATTTCATCTTTGTTTTGGATATAATCAGCAGGTTGATGCAA
GTTGGAGAAGAATTTTGTGGTAGCAAGTCTGAAGTTTTACAGGAATCTATTAGAAAACAAAGTGTCAATTATTTCAAGAATTACCATAGA
ACACGGCTCGATGAACTGAGAATGTTCTTAGAGAATGAGACTTGGGAACTTTGTCCTGTTAAGTCAAATTTCAGCATCTTGCAACTTCAT
GAATTTAAATTCATGGAACAGTCTCGCTCCCCATCAGTTTCACCTAGTAAACAGCCAGTCTCAACTTCTTCAAAAACAGTGACCTTGTTT
GAGCAGTACTGTAGTGGTGGGAATCCATTTGAAATTCAGGCCAACCACAAAGATGAAGAAACAGAAGATGTCTTAGCTTCTAATGGGTAT
GAATCTGATGAACAAGAAAAGAGTGCCTATCAAGAGTATGACAGTGACAGTGATGTTCCTGAGGAACTCAAACGAGACTATGTGGATGAG
CAGACAGGAGATGGTCCTGTGAAAAGTGTTTCTCGGGAAACTCTAAAAAGCAGGAAGAAATCAGATTACAGTCTAAATAAAGTGAATGCA
CCTATCTTAACAAATACAACATTGAACGTCATAAGACTTGTTGGAAAATATATGCAGATGATGAACATTCTTAAGCCAATTGCCTTTGAT
GTTATTCATTTCATGTCTCAACTATTTGATTATTACTTGTATGCAATATATACCTTTTTTGGTCGGAATGATTCATTGGAATCAACTGGA
CTCGGCCTTAGTAGTAGTAGACTAAGAACAACTCTAAACAGAATACAAGAAAGCCTTATTGATCTAGAAGTTTCAGCTGATCCTACTGCC
ACACTCACAGCAGCAGAAGAAAGAAAGGAGAAGGTGCCAAGTCCACACCTCAGTCACCTAGTGGTTTTGACATCTGGGGATACGCTGTAT
GGGTTGGCAGAAAGAGTGGTAGCCACGGAATCCTTGGTATTCTTGGCTGAACAGTTTGAGTTCCTTCAGCCACATCTGGATGCTGTGATG
CCTGCAGTCAAAAAGCCCTTTCTTCAGCAGTTCTATTCTCAGACAGTCTCAACCGCCAGTGAACTACGGAAACCAATTTACTGGATTGTA
GCTGGTAAAGCCCTTGATTATGAACAGATGCTGCTTCTCATGGCTAATGTGAAATGGGATGTAAAAGAAATTATGTCACAGCACAACATA
TATGTAGATGCACTATTAAAGGAATTTGAGCAGTTTAACAGGAGGCTAAATGAAGTTTCTAAGAGAGTTCGCATACCCTTGCCTGTGTCT
AATATACTTTGGGAACATTGTATACGATTGGCTAATCGAACTATTGTAGAAGGATATGCCAATGTCAAGAAATGCAGTAATGAGGGTCGT
GCCCTGATGCAATTGGATTTTCAACAGTTTTTAATGAAACTTGAAAAACTAACAGATATTAGACCCATTCCTGATAAAGAATTTGTAGAA
ACTTATATTAAAGCTTATTACCTAACTGAGAATGACATGGAACGGTGGATCAAAGAGCACAGGGAATATTCAACGAAGCAGCTGACCAAT
CTGGTGAATGTTTGCCTGGGATCCCATATCAATAAGAAAGCAAGACAAAAACTTCTAGCAGCTATAGATGATATAGACAGACCTAAAAGA
TAATGAACACAGCTCTCTTTCCTCAATGGCATTGATCCTCACTCAACATATATGACCTGAAAGCCAGTTTTTTTATGCACTTCTGACAAC
TATCTGCTAAGAAAACTTTGTGCATGTTTTTTTGACTGGAAAGTGGAAAATATTGAAATGTGTGTGGTGTTCTCATGACTTTTATATGCT
GTGGTCTCTTCAACTTTTGGTCTCATTTGTTGTAATCTGAAATGATGTTGCCGCCTTGTCATAACAATGGTTATGTGACTACAGTTATAC
ATTTTACAGAAGAATGTACCATAAGTATATAATTAGAAGAACAGTGGCTTAATATATGTATGGGAAGTTTATGGAAAATGAAGTTGGCAC
TTTTCTACCCTCTGAGCTTGGTTCTTAATAAGCATAATGTGAGGGTGAATATGTAGTATCTCCTAATTATGAGCACTGCATGAGAATTAA
AAAACACATGTAAGTAAAATAGTTGAAAAATCAGTATGTTCTCTGTTTTTAAAATGTCAAAGTTTATGTCAGGGTTAATTTAGTTATAAC

>51138_51138_1_MAOA-CCDC132_MAOA_chrX_43552675_ENST00000338702_CCDC132_chr7_92905477_ENST00000305866_length(amino acids)=824AA_BP=127
MIEGSFPPFAVPTPVPTTQERVSQSMENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDV
GGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKTAMDQLHMHFTQAIHNTVFQVVLGYVELCAGNTDTKFQKLQYKDLCTHVTPDS
YIPCLADLCKALWEVMLSYYRTMEWHEKHDNEDTASASEGSNMIGTEETNFDRGYIKKKLEHGLTRIWQDVQLKVKTYLLGTDLSIFKYD
DFIFVLDIISRLMQVGEEFCGSKSEVLQESIRKQSVNYFKNYHRTRLDELRMFLENETWELCPVKSNFSILQLHEFKFMEQSRSPSVSPS
KQPVSTSSKTVTLFEQYCSGGNPFEIQANHKDEETEDVLASNGYESDEQEKSAYQEYDSDSDVPEELKRDYVDEQTGDGPVKSVSRETLK
SRKKSDYSLNKVNAPILTNTTLNVIRLVGKYMQMMNILKPIAFDVIHFMSQLFDYYLYAIYTFFGRNDSLESTGLGLSSSRLRTTLNRIQ
ESLIDLEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAERVVATESLVFLAEQFEFLQPHLDAVMPAVKKPFLQQFYSQTV
STASELRKPIYWIVAGKALDYEQMLLLMANVKWDVKEIMSQHNIYVDALLKEFEQFNRRLNEVSKRVRIPLPVSNILWEHCIRLANRTIV
EGYANVKKCSNEGRALMQLDFQQFLMKLEKLTDIRPIPDKEFVETYIKAYYLTENDMERWIKEHREYSTKQLTNLVNVCLGSHINKKARQ

--------------------------------------------------------------
>51138_51138_2_MAOA-CCDC132_MAOA_chrX_43552675_ENST00000338702_CCDC132_chr7_92905477_ENST00000541136_length(transcript)=3107nt_BP=429nt
CGGGTATCAAAAGAAGGATCGGCTCCGCCCCCGGGCTCCCCGGGGGAGTTGATAGAAGGGTCCTTCCCACCCTTTGCCGTCCCCACTCCT
GTGCCTACGACCCAGGAGCGTGTCAGCCAAAGCATGGAGAATCAAGAGAAGGCGAGTATCGCGGGCCACATGTTCGACGTAGTCGTGATC
GGAGGTGGCATTTCAGGACTATCTGCTGCCAAACTCTTGACTGAATATGGCGTTAGTGTTTTGGTTTTAGAAGCTCGGGACAGGGTTGGA
GGAAGAACATATACTATAAGGAATGAGCATGTTGATTACGTAGATGTTGGTGGAGCTTATGTGGGACCAACCCAAAACAGAATCTTACGC
TTGTCTAAGGAGCTGGGCATAGAGACTTACAAAGTGAATGTCAGTGAGCGTCTCGTTCAATATGTCAAGACAGCAATGGATCAACTTCAT
ATGCACTTCACCCAAGCCATTCACAACACCGTGTTTCAAGTTGTTCTTGGTTATGTGGAACTATGTGCAGGAAACACAGACACAAAATTC
CAAAAGCTGCAATATAAGGATCTCTGTACACATGTTACACCAGACAGCTATATTCCATGCCTTGCAGACCTGTGCAAAGCACTATGGGAA
GTTATGCTCAGCTATTATAGGACTATGGAATGGCATGAAAAGCATGACAATGAGGATACTGCTTCAGCTTCTGAAGGGAGTAATATGATA
GGTACTGAAGAAACTAATTTTGATCGTGGCTACATAAAAAAGAAATTAGAACATGGACTTACACGAATATGGCAGGATGTTCAGCTAAAA
GTAAAAACCTACTTGCTTGGAACTGATTTGTCTATATTCAAATATGATGATTTCATCTTTGTTTTGGATATAATCAGCAGGTTGATGCAA
GTTGGAGAAGAATTTTGTGGTAGCAAGTCTGAAGTTTTACAGGAATCTATTAGAAAACAAAGTGTCAATTATTTCAAGAATTACCATAGA
ACACGGCTCGATGAACTGAGAATGTTCTTAGAGAATGAGACTTGGGAACTTTGTCCTGTTAAGTCAAATTTCAGCATCTTGCAACTTCAT
GAATTTAAATTCATGGAACAGTCTCGCTCCCCATCAGTTTCACCTAGTAAACAGCCAGTCTCAACTTCTTCAAAAACAGTGACCTTGTTT
GAGCAGTACTGTAGTGGTGGGAATCCATTTGAAATTCAGGCCAACCACAAAGATGAAGAAACAGAAGATGTCTTAGCTTCTAATGGGTAT
GAATCTGATGAACAAGAAAAGAGTGCCTATCAAGAGTATGACAGTGACAGTGATGTTCCTGAGGAACTCAAACGAGACTATGTGGATGAG
CAGACAGGAGATGGTCCTGTGAAAAGTGTTTCTCGGGAAACTCTAAAAAGCAGGAAGAAATCAGATTACAGTCTAAATAAAGTGAATGCA
CCTATCTTAACAAATACAACATTGAACGTCATAAGACTTGTTGGAAAATATATGCAGATGATGAACATTCTTAAGCCAATTGCCTTTGAT
GTTATTCATTTCATGTCTCAACTATTTGATTATTACTTGTATGCAATATATACCTTTTTTGGTCGGAATGATTCATTGGAATCAACTGGA
CTCGGCCTTAGTAGTAGTAGACTAAGAACAACTCTAAACAGAATACAAGAAAGCCTTATTGATCTAGAAGTTTCAGCTGATCCTACTGCC
ACACTCACAGCAGCAGAAGAAAGAAAGGAGAAGGTGCCAAGTCCACACCTCAGTCACCTAGTGGTTTTGACATCTGGGGATACGCTGTAT
GGGTTGGCAGAAAGAGTGGTAGCCACGGAATCCTTGGTATTCTTGGCTGAACAGTTTGAGTTCCTTCAGCCACATCTGGATGCTGTGATG
CCTGCAGTCAAAAAGCCCTTTCTTCAGCAGTTCTATTCTCAGTCTCAACCGCCAGTGAACTACGGAAACCAATTTACTGGATTGTAGCTG
GTAAAGCCCTTGATTATGAACAGATGCTGCTTCTCATGGCTAATGTGAAATGGGATGTAAAAGAAATTATGTCACAGCACAACATATATG
TAGATGCACTATTAAAGGAATTTGAGCAGTTTAACAGGAGGCTAAATGAAGTTTCTAAGAGAGTTCGCATACCCTTGCCTGTGTCTAATA
TACTTTGGGAACATTGTATACGATTGGCTAATCGAACTATTGTAGAAGGATATGCCAATGTCAAGAAATGCAGTAATGAGGGTCGTGCCC
TGATGCAATTGGATTTTCAACAGTTTTTAATGAAACTTGAAAAACTAACAGATATTAGACCCATTCCTGATAAAGAATTTGTAGAAACTT
ATATTAAAGCTTATTACCTAACTGAGAATGACATGGAACGGTGGATCAAAGAGCACAGGGAATATTCAACGAAGCAGCTGACCAATCTGG
TGAATGTTTGCCTGGGATCCCATATCAATAAGAAAGCAAGACAAAAACTTCTAGCAGCTATAGATGATATAGACAGACCTAAAAGATAAT
GAACACAGCTCTCTTTCCTCAATGGCATTGATCCTCACTCAACATATATGACCTGAAAGCCAGTTTTTTTATGCACTTCTGACAACTATC
TGCTAAGAAAACTTTGTGCATGTTTTTTTGACTGGAAAGTGGAAAATATTGAAATGTGTGTGGTGTTCTCATGACTTTTATATGCTGTGG
TCTCTTCAACTTTTGGTCTCATTTGTTGTAATCTGAAATGATGTTGCCGCCTTGTCATAACAATGGTTATGTGACTACAGTTATACATTT
TACAGAAGAATGTACCATAAGTATATAATTAGAAGAACAGTGGCTTAATATATGTATGGGAAGTTTATGGAAAATGAAGTTGGCACTTTT
CTACCCTCTGAGCTTGGTTCTTAATAAGCATAATGTGAGGGTGAATATGTAGTATCTCCTAATTATGAGCACTGCATGAGAATTAAAAAA
CACATGTAAGTAAAATAGTTGAAAAATCAGTATGTTCTCTGTTTTTAAAATGTCAAAGTTTATGTCAGGGTTAATTTAGTTATAACAAAG

>51138_51138_2_MAOA-CCDC132_MAOA_chrX_43552675_ENST00000338702_CCDC132_chr7_92905477_ENST00000541136_length(amino acids)=642AA_BP=127
MIEGSFPPFAVPTPVPTTQERVSQSMENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDV
GGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKTAMDQLHMHFTQAIHNTVFQVVLGYVELCAGNTDTKFQKLQYKDLCTHVTPDS
YIPCLADLCKALWEVMLSYYRTMEWHEKHDNEDTASASEGSNMIGTEETNFDRGYIKKKLEHGLTRIWQDVQLKVKTYLLGTDLSIFKYD
DFIFVLDIISRLMQVGEEFCGSKSEVLQESIRKQSVNYFKNYHRTRLDELRMFLENETWELCPVKSNFSILQLHEFKFMEQSRSPSVSPS
KQPVSTSSKTVTLFEQYCSGGNPFEIQANHKDEETEDVLASNGYESDEQEKSAYQEYDSDSDVPEELKRDYVDEQTGDGPVKSVSRETLK
SRKKSDYSLNKVNAPILTNTTLNVIRLVGKYMQMMNILKPIAFDVIHFMSQLFDYYLYAIYTFFGRNDSLESTGLGLSSSRLRTTLNRIQ
ESLIDLEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAERVVATESLVFLAEQFEFLQPHLDAVMPAVKKPFLQQFYSQSQ

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>51138_51138_3_MAOA-CCDC132_MAOA_chrX_43552675_ENST00000338702_CCDC132_chr7_92905477_ENST00000544910_length(transcript)=3112nt_BP=429nt
CGGGTATCAAAAGAAGGATCGGCTCCGCCCCCGGGCTCCCCGGGGGAGTTGATAGAAGGGTCCTTCCCACCCTTTGCCGTCCCCACTCCT
GTGCCTACGACCCAGGAGCGTGTCAGCCAAAGCATGGAGAATCAAGAGAAGGCGAGTATCGCGGGCCACATGTTCGACGTAGTCGTGATC
GGAGGTGGCATTTCAGGACTATCTGCTGCCAAACTCTTGACTGAATATGGCGTTAGTGTTTTGGTTTTAGAAGCTCGGGACAGGGTTGGA
GGAAGAACATATACTATAAGGAATGAGCATGTTGATTACGTAGATGTTGGTGGAGCTTATGTGGGACCAACCCAAAACAGAATCTTACGC
TTGTCTAAGGAGCTGGGCATAGAGACTTACAAAGTGAATGTCAGTGAGCGTCTCGTTCAATATGTCAAGACAGCAATGGATCAACTTCAT
ATGCACTTCACCCAAGCCATTCACAACACCGTGTTTCAAGTTGTTCTTGGTTATGTGGAACTATGTGCAGGAAACACAGACACAAAATTC
CAAAAGCTGCAATATAAGGATCTCTGTACACATGTTACACCAGACAGCTATATTCCATGCCTTGCAGACCTGTGCAAAGCACTATGGGAA
GTTATGCTCAGCTATTATAGGACTATGGAATGGCATGAAAAGCATGACAATGAGGATACTGCTTCAGCTTCTGAAGGGAGTAATATGATA
GGTACTGAAGAAACTAATTTTGATCGTGGCTACATAAAAAAGAAATTAGAACATGGACTTACACGAATATGGCAGGATGTTCAGCTAAAA
GTAAAAACCTACTTGCTTGGAACTGATTTGTCTATATTCAAATATGATGATTTCATCTTTGTTTTGGATATAATCAGCAGGTTGATGCAA
GTTGGAGAAGAATTTTGTGGTAGCAAGTCTGAAGTTTTACAGGAATCTATTAGAAAACAAAGTGTCAATTATTTCAAGAATTACCATAGA
ACACGGCTCGATGAACTGAGAATGTTCTTAGAGAATGAGACTTGGGAACTTTGTCCTGTTAAGTCAAATTTCAGCATCTTGCAACTTCAT
GAATTTAAATTCATGGAACAGTCTCGCTCCCCATCAGTTTCACCTAGTAAACAGCCAGTCTCAACTTCTTCAAAAACAGTGACCTTGTTT
GAGCAGTACTGTAGTGGTGGGAATCCATTTGAAATTCAGGCCAACCACAAAGATGAAGAAACAGAAGATGTCTTAGCTTCTAATGGGTAT
GAATCTGATGAACAAGAAAAGAGTGCCTATCAAGAGTATGACAGTGACAGTGATGTTCCTGAGGAACTCAAACGAGACTATGTGGATGAG
CAGACAGGAGATGGTCCTGTGAAAAGTGTTTCTCGGGAAACTCTAAAAAGCAGGAAGAAATCAGATTACAGTCTAAATAAAGTGAATGCA
CCTATCTTAACAAATACAACATTGAACGTCATAAGACTTGTTGGAAAATATATGCAGATGATGAACATTCTTAAGCCAATTGCCTTTGAT
GTTATTCATTTCATGTCTCAACTATTTGATTATTACTTGTATGCAATATATACCTTTTTTGGTCGGAATGATTCATTGGAATCAACTGGA
CTCGGCCTTAGTAGTAGTAGACTAAGAACAACTCTAAACAGAATACAAGAAAGCCTTATTGATCTAGAAGTTTCAGCTGATCCTACTGCC
ACACTCACAGCAGCAGAAGAAAGAAAGGAGAAGGTGCCAAGTCCACACCTCAGTCACCTAGTGGTTTTGACATCTGGGGATACGCTGTAT
GGGTTGGCAGAAAGAGTGGTAGCCACGGAATCCTTGGTATTCTTGGCTGAACAGTTTGAGTTCCTTCAGCCACATCTGGATGCTGTGATG
CCTGCAGTCAAAAAGCCCTTTCTTCAGCAGTTCTATTCTCAGACAGTCTCAACCGCCAGTGAACTACGGAAACCAATTTACTGGATTGTA
GCTGGTAAAGCCCTTGATTATGAACAGATGCTGCTTCTCATGGCTAATGTGAAATGGGATGTAAAAGAAATTATGTCACAGCACAACATA
TATGTAGATGCACTATTAAAGGAATTTGAGCAGTTTAACAGGAGGCTAAATGAAGTTTCTAAGAGAGTTCGCATACCCTTGCCTGTGTCT
AATATACTTTGGGAACATTGTATACGATTGGCTAATCGAACTATTGTAGAAGGATATGCCAATGTCAAGAAATGCAGTAATGAGGGTCGT
GCCCTGATGCAATTGGATTTTCAACAGTTTTTAATGAAACTTGAAAAACTAACAGATATTAGACCCATTCCTGATAAAGAATTTGTAGAA
ACTTATATTAAAGCTTATTACCTAACTGAGAATGACATGGAACGGTGGATCAAAGAGCACAGGGAATATTCAACGAAGCAGCTGACCAAT
CTGGTGAATGTTTGCCTGGGATCCCATATCAATAAGAAAGCAAGACAAAAACTTCTAGCAGCTATAGATGATATAGACAGACCTAAAAGA
TAATGAACACAGCTCTCTTTCCTCAATGGCATTGATCCTCACTCAACATATATGACCTGAAAGCCAGTTTTTTTATGCACTTCTGACAAC
TATCTGCTAAGAAAACTTTGTGCATGTTTTTTTGACTGGAAAGTGGAAAATATTGAAATGTGTGTGGTGTTCTCATGACTTTTATATGCT
GTGGTCTCTTCAACTTTTGGTCTCATTTGTTGTAATCTGAAATGATGTTGCCGCCTTGTCATAACAATGGTTATGTGACTACAGTTATAC
ATTTTACAGAAGAATGTACCATAAGTATATAATTAGAAGAACAGTGGCTTAATATATGTATGGGAAGTTTATGGAAAATGAAGTTGGCAC
TTTTCTACCCTCTGAGCTTGGTTCTTAATAAGCATAATGTGAGGGTGAATATGTAGTATCTCCTAATTATGAGCACTGCATGAGAATTAA
AAAACACATGTAAGTAAAATAGTTGAAAAATCAGTATGTTCTCTGTTTTTAAAATGTCAAAGTTTATGTCAGGGTTAATTTAGTTATAAC

>51138_51138_3_MAOA-CCDC132_MAOA_chrX_43552675_ENST00000338702_CCDC132_chr7_92905477_ENST00000544910_length(amino acids)=824AA_BP=127
MIEGSFPPFAVPTPVPTTQERVSQSMENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDV
GGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKTAMDQLHMHFTQAIHNTVFQVVLGYVELCAGNTDTKFQKLQYKDLCTHVTPDS
YIPCLADLCKALWEVMLSYYRTMEWHEKHDNEDTASASEGSNMIGTEETNFDRGYIKKKLEHGLTRIWQDVQLKVKTYLLGTDLSIFKYD
DFIFVLDIISRLMQVGEEFCGSKSEVLQESIRKQSVNYFKNYHRTRLDELRMFLENETWELCPVKSNFSILQLHEFKFMEQSRSPSVSPS
KQPVSTSSKTVTLFEQYCSGGNPFEIQANHKDEETEDVLASNGYESDEQEKSAYQEYDSDSDVPEELKRDYVDEQTGDGPVKSVSRETLK
SRKKSDYSLNKVNAPILTNTTLNVIRLVGKYMQMMNILKPIAFDVIHFMSQLFDYYLYAIYTFFGRNDSLESTGLGLSSSRLRTTLNRIQ
ESLIDLEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAERVVATESLVFLAEQFEFLQPHLDAVMPAVKKPFLQQFYSQTV
STASELRKPIYWIVAGKALDYEQMLLLMANVKWDVKEIMSQHNIYVDALLKEFEQFNRRLNEVSKRVRIPLPVSNILWEHCIRLANRTIV
EGYANVKKCSNEGRALMQLDFQQFLMKLEKLTDIRPIPDKEFVETYIKAYYLTENDMERWIKEHREYSTKQLTNLVNVCLGSHINKKARQ

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Fusion Gene PPI Analysis for MAOA-CCDC132


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMAOAchrX:43552675chr7:92905477ENST00000338702+315520_522102.0528.0membrane phospholipid headgroups
HgeneMAOAchrX:43552675chr7:92905477ENST00000542639+416520_5220395.0membrane phospholipid headgroups


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAOA-CCDC132


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMAOAP21397DB00780PhenelzineAntagonistSmall moleculeApproved
HgeneMAOAP21397DB00805MinaprineInhibitorSmall moleculeApproved
HgeneMAOAP21397DB01247IsocarboxazidInhibitorSmall moleculeApproved
HgeneMAOAP21397DB01626PargylineInhibitorSmall moleculeApproved
HgeneMAOAP21397DB03147Flavin adenine dinucleotideSmall moleculeApproved
HgeneMAOAP21397DB00191PhentermineAntagonistSmall moleculeApproved|Illicit
HgeneMAOAP21397DB01577MetamfetamineInhibitorSmall moleculeApproved|Illicit
HgeneMAOAP21397DB00752TranylcypromineInhibitorSmall moleculeApproved|Investigational
HgeneMAOAP21397DB00909ZonisamideInhibitorSmall moleculeApproved|Investigational
HgeneMAOAP21397DB01171MoclobemideAntagonist|InhibitorSmall moleculeApproved|Investigational
HgeneMAOAP21397DB14914Flortaucipir F-18BinderSmall moleculeApproved|Investigational
HgeneMAOAP21397DB01037SelegilineInhibitorSmall moleculeApproved|Investigational|Vet_approved
HgeneMAOAP21397DB04820NialamideSmall moleculeApproved|Withdrawn
HgeneMAOAP21397DB04821NomifensineSmall moleculeApproved|Withdrawn
HgeneMAOAP21397DB04832ZimelidineInhibitorSmall moleculeApproved|Withdrawn

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Related Diseases for MAOA-CCDC132


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAOAC0001973Alcoholic Intoxication, Chronic5PSYGENET
HgeneMAOAC0005586Bipolar Disorder5PSYGENET
HgeneMAOAC0011570Mental Depression5PSYGENET
HgeneMAOAC0011581Depressive disorder5PSYGENET
HgeneMAOAC0041696Unipolar Depression5PSYGENET
HgeneMAOAC0525045Mood Disorders5PSYGENET
HgeneMAOAC1269683Major Depressive Disorder5PSYGENET
HgeneMAOAC0796275Brunner Syndrome4CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneMAOAC0003431Antisocial Personality Disorder3CTD_human
HgeneMAOAC0004352Autistic Disorder3CTD_human
HgeneMAOAC0013409Dyssocial Behavior3CTD_human
HgeneMAOAC0019147Hepatic Coma3CTD_human
HgeneMAOAC0019151Hepatic Encephalopathy3CTD_human
HgeneMAOAC0751197Fulminant Hepatic Failure with Cerebral Edema3CTD_human
HgeneMAOAC0751198Hepatic Stupor3CTD_human
HgeneMAOAC0036341Schizophrenia2PSYGENET
HgeneMAOAC0085762Alcohol abuse2PSYGENET
HgeneMAOAC0270458Severe major depression with psychotic features2PSYGENET
HgeneMAOAC2362914clinical depression2PSYGENET
HgeneMAOAC0004930Behavior Disorders1CTD_human
HgeneMAOAC0004936Mental disorders1CTD_human
HgeneMAOAC0005587Depression, Bipolar1PSYGENET
HgeneMAOAC0009241Cognition Disorders1CTD_human
HgeneMAOAC0013415Dysthymic Disorder1PSYGENET
HgeneMAOAC0014175Endometriosis1CTD_human
HgeneMAOAC0020179Huntington Disease1CTD_human
HgeneMAOAC0020649Hypotension1CTD_human
HgeneMAOAC0026848Myopathy1CTD_human
HgeneMAOAC0030567Parkinson Disease1CTD_human
HgeneMAOAC0031511Pheochromocytoma1CTD_human
HgeneMAOAC0033054Prenatal Exposure Delayed Effects1CTD_human
HgeneMAOAC0033975Psychotic Disorders1PSYGENET
HgeneMAOAC0038644Sudden infant death syndrome1GENOMICS_ENGLAND
HgeneMAOAC0158850Fetal Malnutrition1CTD_human
HgeneMAOAC0269102Endometrioma1CTD_human
HgeneMAOAC0376338Diagnosis, Psychiatric1CTD_human
HgeneMAOAC0393574Huntington Disease, Late Onset1CTD_human
HgeneMAOAC0600427Cocaine Dependence1PSYGENET
HgeneMAOAC0745744End Stage Liver Disease1CTD_human
HgeneMAOAC0751207Akinetic-Rigid Variant of Huntington Disease1CTD_human
HgeneMAOAC0751208Juvenile Huntington Disease1CTD_human
HgeneMAOAC1136249Mental Retardation, X-Linked1CTD_human
HgeneMAOAC1257877Pheochromocytoma, Extra-Adrenal1CTD_human
HgeneMAOAC1285261Fetal Nutrition Disorders1CTD_human
HgeneMAOAC2063866Depressive Disorder, Treatment-Resistant1PSYGENET
HgeneMAOAC2936476Chronic Liver Failure1CTD_human
HgeneMAOAC4046029Mental Disorders, Severe1CTD_human