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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAP2-EZR (FusionGDB2 ID:HG4133TG7430)

Fusion Gene Summary for MAP2-EZR

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP2-EZR
Fusion gene ID: hg4133tg7430
HgeneTgene
Gene symbol

MAP2

EZR

Gene ID

4133

7430

Gene namemicrotubule associated protein 2ezrin
SynonymsMAP-2|MAP2A|MAP2B|MAP2CCVIL|CVL|HEL-S-105|VIL2
Cytomap('MAP2')('EZR')

2q34

6q25.3

Type of geneprotein-codingprotein-coding
Descriptionmicrotubule-associated protein 2ezrincytovillin 2epididymis secretory protein Li 105p81villin 2 (ezrin)
Modification date2020031320200322
UniProtAcc

P11137

P15311

Ensembl transtripts involved in fusion geneENST00000199940, ENST00000360351, 
ENST00000361559, ENST00000392194, 
ENST00000447185, ENST00000475600, 
Fusion gene scores* DoF score12 X 9 X 6=64825 X 24 X 6=3600
# samples 1227
** MAII scorelog2(12/648*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/3600*10)=-3.73696559416621
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAP2 [Title/Abstract] AND EZR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAP2(210575812)-EZR(159197475), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneEZR

GO:0048015

phosphatidylinositol-mediated signaling

25591774

TgeneEZR

GO:0051017

actin filament bundle assembly

10793131



check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AFN139454MAP2chr2

210575812

+EZRchr6

159197475

+


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Fusion Gene ORF analysis for MAP2-EZR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000199940ENST00000337147MAP2chr2

210575812

+EZRchr6

159197475

+
intron-3CDSENST00000199940ENST00000367075MAP2chr2

210575812

+EZRchr6

159197475

+
intron-3CDSENST00000199940ENST00000392177MAP2chr2

210575812

+EZRchr6

159197475

+
intron-3CDSENST00000360351ENST00000337147MAP2chr2

210575812

+EZRchr6

159197475

+
intron-3CDSENST00000360351ENST00000367075MAP2chr2

210575812

+EZRchr6

159197475

+
intron-3CDSENST00000360351ENST00000392177MAP2chr2

210575812

+EZRchr6

159197475

+
intron-3CDSENST00000361559ENST00000337147MAP2chr2

210575812

+EZRchr6

159197475

+
intron-3CDSENST00000361559ENST00000367075MAP2chr2

210575812

+EZRchr6

159197475

+
intron-3CDSENST00000361559ENST00000392177MAP2chr2

210575812

+EZRchr6

159197475

+
intron-3CDSENST00000392194ENST00000337147MAP2chr2

210575812

+EZRchr6

159197475

+
intron-3CDSENST00000392194ENST00000367075MAP2chr2

210575812

+EZRchr6

159197475

+
intron-3CDSENST00000392194ENST00000392177MAP2chr2

210575812

+EZRchr6

159197475

+
intron-3CDSENST00000447185ENST00000337147MAP2chr2

210575812

+EZRchr6

159197475

+
intron-3CDSENST00000447185ENST00000367075MAP2chr2

210575812

+EZRchr6

159197475

+
intron-3CDSENST00000447185ENST00000392177MAP2chr2

210575812

+EZRchr6

159197475

+
intron-3CDSENST00000475600ENST00000337147MAP2chr2

210575812

+EZRchr6

159197475

+
intron-3CDSENST00000475600ENST00000367075MAP2chr2

210575812

+EZRchr6

159197475

+
intron-3CDSENST00000475600ENST00000392177MAP2chr2

210575812

+EZRchr6

159197475

+
intron-intronENST00000199940ENST00000476189MAP2chr2

210575812

+EZRchr6

159197475

+
intron-intronENST00000360351ENST00000476189MAP2chr2

210575812

+EZRchr6

159197475

+
intron-intronENST00000361559ENST00000476189MAP2chr2

210575812

+EZRchr6

159197475

+
intron-intronENST00000392194ENST00000476189MAP2chr2

210575812

+EZRchr6

159197475

+
intron-intronENST00000447185ENST00000476189MAP2chr2

210575812

+EZRchr6

159197475

+
intron-intronENST00000475600ENST00000476189MAP2chr2

210575812

+EZRchr6

159197475

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MAP2-EZR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for MAP2-EZR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:210575812/:159197475)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP2

P11137

EZR

P15311

FUNCTION: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.FUNCTION: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MAP2-EZR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MAP2-EZR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAP2-EZR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMAP2P11137DB01196EstramustineAntagonistSmall moleculeApproved|Investigational
HgeneMAP2P11137DB01248DocetaxelSmall moleculeApproved|Investigational
HgeneMAP2P11137DB01229PaclitaxelSmall moleculeApproved|Vet_approved

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Related Diseases for MAP2-EZR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAP2C0000786Spontaneous abortion1CTD_human
HgeneMAP2C0000822Abortion, Tubal1CTD_human
HgeneMAP2C0005586Bipolar Disorder1PSYGENET
HgeneMAP2C0030567Parkinson Disease1CTD_human
HgeneMAP2C0041696Unipolar Depression1PSYGENET
HgeneMAP2C0087031Juvenile-Onset Still Disease1CTD_human
HgeneMAP2C0525045Mood Disorders1PSYGENET
HgeneMAP2C0752347Lewy Body Disease1CTD_human
HgeneMAP2C1269683Major Depressive Disorder1PSYGENET
HgeneMAP2C3495559Juvenile arthritis1CTD_human
HgeneMAP2C3714758Juvenile psoriatic arthritis1CTD_human
HgeneMAP2C3830362Early Pregnancy Loss1CTD_human
HgeneMAP2C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneMAP2C4552766Miscarriage1CTD_human
HgeneMAP2C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
TgeneC0033578Prostatic Neoplasms3CTD_human
TgeneC0376358Malignant neoplasm of prostate3CTD_human
TgeneC0007097Carcinoma1CTD_human
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC0024667Animal Mammary Neoplasms1CTD_human
TgeneC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneC0027627Neoplasm Metastasis1CTD_human
TgeneC0029408Degenerative polyarthritis1CTD_human
TgeneC0086743Osteoarthrosis Deformans1CTD_human
TgeneC0205696Anaplastic carcinoma1CTD_human
TgeneC0205697Carcinoma, Spindle-Cell1CTD_human
TgeneC0205698Undifferentiated carcinoma1CTD_human
TgeneC0205699Carcinomatosis1CTD_human
TgeneC1257925Mammary Carcinoma, Animal1CTD_human