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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:MTIF2-SMEK2 (FusionGDB2 ID:HG4528TG57223) |
Fusion Gene Summary for MTIF2-SMEK2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: MTIF2-SMEK2 | Fusion gene ID: hg4528tg57223 | Hgene | Tgene | Gene symbol | MTIF2 | SMEK2 | Gene ID | 4528 | 57223 |
Gene name | mitochondrial translational initiation factor 2 | protein phosphatase 4 regulatory subunit 3B | |
Synonyms | - | FLFL2|PP4R3B|PSY2|SMEK2|smk1 | |
Cytomap | ('MTIF2')('SMEK2') 2p16.1 | 2p16.1 | |
Type of gene | protein-coding | protein-coding | |
Description | translation initiation factor IF-2, mitochondrialIF-2mt | serine/threonine-protein phosphatase 4 regulatory subunit 3BSMEK homolog 2, suppressor of mek1 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | P46199 | . | |
Ensembl transtripts involved in fusion gene | ENST00000263629, ENST00000394600, ENST00000403721, ENST00000446660, | ||
Fusion gene scores | * DoF score | 6 X 8 X 4=192 | 2 X 1 X 1=2 |
# samples | 11 | 2 | |
** MAII score | log2(11/192*10)=-0.803602787196497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/2*10)=3.32192809488736 | |
Context | PubMed: MTIF2 [Title/Abstract] AND SMEK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | MTIF2(55489452)-SMEK2(55842642), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | MTIF2-SMEK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MTIF2-SMEK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MTIF2-SMEK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MTIF2-SMEK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MTIF2-SMEK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. MTIF2-SMEK2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene breakpoints across MTIF2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across SMEK2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-D7-6822-01A | MTIF2 | chr2 | 55489452 | - | SMEK2 | chr2 | 55842642 | - |
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Fusion Gene ORF analysis for MTIF2-SMEK2 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000263629 | ENST00000477749 | MTIF2 | chr2 | 55489452 | - | SMEK2 | chr2 | 55842642 | - |
5CDS-5UTR | ENST00000394600 | ENST00000477749 | MTIF2 | chr2 | 55489452 | - | SMEK2 | chr2 | 55842642 | - |
5CDS-5UTR | ENST00000403721 | ENST00000477749 | MTIF2 | chr2 | 55489452 | - | SMEK2 | chr2 | 55842642 | - |
5UTR-3CDS | ENST00000446660 | ENST00000272313 | MTIF2 | chr2 | 55489452 | - | SMEK2 | chr2 | 55842642 | - |
5UTR-3CDS | ENST00000446660 | ENST00000345102 | MTIF2 | chr2 | 55489452 | - | SMEK2 | chr2 | 55842642 | - |
5UTR-3CDS | ENST00000446660 | ENST00000407823 | MTIF2 | chr2 | 55489452 | - | SMEK2 | chr2 | 55842642 | - |
5UTR-5UTR | ENST00000446660 | ENST00000477749 | MTIF2 | chr2 | 55489452 | - | SMEK2 | chr2 | 55842642 | - |
Frame-shift | ENST00000263629 | ENST00000272313 | MTIF2 | chr2 | 55489452 | - | SMEK2 | chr2 | 55842642 | - |
Frame-shift | ENST00000263629 | ENST00000345102 | MTIF2 | chr2 | 55489452 | - | SMEK2 | chr2 | 55842642 | - |
Frame-shift | ENST00000263629 | ENST00000407823 | MTIF2 | chr2 | 55489452 | - | SMEK2 | chr2 | 55842642 | - |
Frame-shift | ENST00000403721 | ENST00000272313 | MTIF2 | chr2 | 55489452 | - | SMEK2 | chr2 | 55842642 | - |
Frame-shift | ENST00000403721 | ENST00000345102 | MTIF2 | chr2 | 55489452 | - | SMEK2 | chr2 | 55842642 | - |
Frame-shift | ENST00000403721 | ENST00000407823 | MTIF2 | chr2 | 55489452 | - | SMEK2 | chr2 | 55842642 | - |
In-frame | ENST00000394600 | ENST00000272313 | MTIF2 | chr2 | 55489452 | - | SMEK2 | chr2 | 55842642 | - |
In-frame | ENST00000394600 | ENST00000345102 | MTIF2 | chr2 | 55489452 | - | SMEK2 | chr2 | 55842642 | - |
In-frame | ENST00000394600 | ENST00000407823 | MTIF2 | chr2 | 55489452 | - | SMEK2 | chr2 | 55842642 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000394600 | MTIF2 | chr2 | 55489452 | - | ENST00000272313 | SMEK2 | chr2 | 55842642 | - | 5840 | 1068 | 698 | 3220 | 840 |
ENST00000394600 | MTIF2 | chr2 | 55489452 | - | ENST00000407823 | SMEK2 | chr2 | 55842642 | - | 4913 | 1068 | 698 | 3379 | 893 |
ENST00000394600 | MTIF2 | chr2 | 55489452 | - | ENST00000345102 | SMEK2 | chr2 | 55842642 | - | 5008 | 1068 | 698 | 3475 | 925 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000394600 | ENST00000272313 | MTIF2 | chr2 | 55489452 | - | SMEK2 | chr2 | 55842642 | - | 0.000254987 | 0.99974495 |
ENST00000394600 | ENST00000407823 | MTIF2 | chr2 | 55489452 | - | SMEK2 | chr2 | 55842642 | - | 0.000231543 | 0.99976844 |
ENST00000394600 | ENST00000345102 | MTIF2 | chr2 | 55489452 | - | SMEK2 | chr2 | 55842642 | - | 0.000181152 | 0.99981886 |
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Fusion Genomic Features for MTIF2-SMEK2 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for MTIF2-SMEK2 |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:55489452/chr2:55842642) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
MTIF2 | . |
FUNCTION: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | SMEK2 | chr2:55489452 | chr2:55842642 | ENST00000272313 | 0 | 15 | 719_724 | 47 | 765.0 | Compositional bias | Note=Poly-Glu | |
Tgene | SMEK2 | chr2:55489452 | chr2:55842642 | ENST00000272313 | 0 | 15 | 831_838 | 47 | 765.0 | Compositional bias | Note=Poly-Glu | |
Tgene | SMEK2 | chr2:55489452 | chr2:55842642 | ENST00000345102 | 0 | 17 | 719_724 | 47 | 850.0 | Compositional bias | Note=Poly-Glu | |
Tgene | SMEK2 | chr2:55489452 | chr2:55842642 | ENST00000345102 | 0 | 17 | 831_838 | 47 | 850.0 | Compositional bias | Note=Poly-Glu | |
Tgene | SMEK2 | chr2:55489452 | chr2:55842642 | ENST00000407823 | 0 | 16 | 719_724 | 47 | 818.0 | Compositional bias | Note=Poly-Glu | |
Tgene | SMEK2 | chr2:55489452 | chr2:55842642 | ENST00000407823 | 0 | 16 | 831_838 | 47 | 818.0 | Compositional bias | Note=Poly-Glu |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | MTIF2 | chr2:55489452 | chr2:55842642 | ENST00000263629 | - | 5 | 16 | 178_348 | 110 | 728.0 | Domain | Note=tr-type G |
Hgene | MTIF2 | chr2:55489452 | chr2:55842642 | ENST00000394600 | - | 6 | 17 | 178_348 | 110 | 728.0 | Domain | Note=tr-type G |
Hgene | MTIF2 | chr2:55489452 | chr2:55842642 | ENST00000403721 | - | 4 | 15 | 178_348 | 110 | 728.0 | Domain | Note=tr-type G |
Hgene | MTIF2 | chr2:55489452 | chr2:55842642 | ENST00000263629 | - | 5 | 16 | 187_194 | 110 | 728.0 | Region | G1 |
Hgene | MTIF2 | chr2:55489452 | chr2:55842642 | ENST00000263629 | - | 5 | 16 | 212_216 | 110 | 728.0 | Region | G2 |
Hgene | MTIF2 | chr2:55489452 | chr2:55842642 | ENST00000263629 | - | 5 | 16 | 234_237 | 110 | 728.0 | Region | G3 |
Hgene | MTIF2 | chr2:55489452 | chr2:55842642 | ENST00000263629 | - | 5 | 16 | 288_291 | 110 | 728.0 | Region | G4 |
Hgene | MTIF2 | chr2:55489452 | chr2:55842642 | ENST00000263629 | - | 5 | 16 | 324_326 | 110 | 728.0 | Region | G5 |
Hgene | MTIF2 | chr2:55489452 | chr2:55842642 | ENST00000394600 | - | 6 | 17 | 187_194 | 110 | 728.0 | Region | G1 |
Hgene | MTIF2 | chr2:55489452 | chr2:55842642 | ENST00000394600 | - | 6 | 17 | 212_216 | 110 | 728.0 | Region | G2 |
Hgene | MTIF2 | chr2:55489452 | chr2:55842642 | ENST00000394600 | - | 6 | 17 | 234_237 | 110 | 728.0 | Region | G3 |
Hgene | MTIF2 | chr2:55489452 | chr2:55842642 | ENST00000394600 | - | 6 | 17 | 288_291 | 110 | 728.0 | Region | G4 |
Hgene | MTIF2 | chr2:55489452 | chr2:55842642 | ENST00000394600 | - | 6 | 17 | 324_326 | 110 | 728.0 | Region | G5 |
Hgene | MTIF2 | chr2:55489452 | chr2:55842642 | ENST00000403721 | - | 4 | 15 | 187_194 | 110 | 728.0 | Region | G1 |
Hgene | MTIF2 | chr2:55489452 | chr2:55842642 | ENST00000403721 | - | 4 | 15 | 212_216 | 110 | 728.0 | Region | G2 |
Hgene | MTIF2 | chr2:55489452 | chr2:55842642 | ENST00000403721 | - | 4 | 15 | 234_237 | 110 | 728.0 | Region | G3 |
Hgene | MTIF2 | chr2:55489452 | chr2:55842642 | ENST00000403721 | - | 4 | 15 | 288_291 | 110 | 728.0 | Region | G4 |
Hgene | MTIF2 | chr2:55489452 | chr2:55842642 | ENST00000403721 | - | 4 | 15 | 324_326 | 110 | 728.0 | Region | G5 |
Tgene | SMEK2 | chr2:55489452 | chr2:55842642 | ENST00000272313 | 0 | 15 | 1_100 | 47 | 765.0 | Domain | Note=WH1 | |
Tgene | SMEK2 | chr2:55489452 | chr2:55842642 | ENST00000345102 | 0 | 17 | 1_100 | 47 | 850.0 | Domain | Note=WH1 | |
Tgene | SMEK2 | chr2:55489452 | chr2:55842642 | ENST00000407823 | 0 | 16 | 1_100 | 47 | 818.0 | Domain | Note=WH1 |
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Fusion Gene Sequence for MTIF2-SMEK2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>55705_55705_1_MTIF2-SMEK2_MTIF2_chr2_55489452_ENST00000394600_SMEK2_chr2_55842642_ENST00000272313_length(transcript)=5840nt_BP=1068nt CGGGGCTGTAGGTAGGAGTTAAGTGGGTAGGATCCCTTAACCAGGGTTGTCCGGTGCAGGTGGTGTGTGTTGTTTCGCCTAACGTGTCAG TGGCACAAATCACGCGAACTTCATAAACATTGTGCGTTCGGAAGCCTTTCCAAGATGCATTTAATCCCTGCGTGAGCCCACGTTAGGCAT TCACGAAGGCATGTGCACTGTTCTCTCGGAAGCGGCTGGCCGGCTTCCCCTCCTCGCGCGCGGCTGTGGGTGCAGGTCCTCACTTCCCAG CCTCCCATGGGCCCAAGGCCTTCTGGGCTCCAATTTGAGGCGAGCCACCCCAGATCCGTAATTTTTCTGCAGTGATTTATTTTTACCTTT CTGATTCCTTGACAAGGATATCCTAGCGGCGAAACAACACCGTACTGGGAGTCAGAACGTCTGGGTTCTAGTCTTGACTGCCATTAACTA GCGGTATGACATTGGAGAAGCTTTTTTGACCCTTCTGGATTTCCGTTTCCTTTTCTGTAAAATGAGGAGCTTGGAAGATCCGGAAAATGA GGCCCATAGGAAACAAGTGACTTGCTGAGTCCAGATAACACTGACTGTCAGAAGTCTCGCTCTGTCTCCCCGGCTGGAGTGCAGTGGCGT GATCTTGGCTCACTGCAACCTCTGTCTCCCGGGTTCAAGAAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCA CCACGCCCAGGAGAAACATGAACCAGAAGCTACTGAAGTTGGAGAACTTGCTACGATTTCACACTATTTATAGGCAACTGCACAGTCTGT GTCAAAGAAGAGCATTAAGACAGTGGAGGCATGGGTTTTCATCTGCTTACCCTGTGTGGACAGCTCAACTGTGTGCCTGGCCCTGGCCAA CAGATGTGCTCACTGGGGCTGCTTTATCTCAGTATAGGCTTCTAGTAACAAAAAAGGAAGAAGGACCATGGAAATCTCAGTTATCTTCAA CAAAATCTAAAAAGGTGGTAGAAGTATGGATTGGAATGACTATTGAGGAACTGGCCAGGGCAATGGAAAAAAACACAGGATCACTACTCT TGGAATCAAAGATAAATCCAAATACTGCATATCAGAAACAACAGGATACATTAATTGTTTGGTCAGAAGCAGAGAACTATGATTTGGCTC TGAGTTTTCAGGAGAAAGCTGGCTGTGATGAGATCTGGGAAAAAATTTGTCAGGTTCAAGGTAAAGACCCATCAGTGGAAGTCACACAGG ACCTCATTGATGAATCTGAAGAAGAACGATTTGAAGAAATGCCTGAAACTAGTCATCTGATTGACCTGCCCACATGTGAACTCAATAAAC TTGAAGAGATTGCTGACTTAGTTACCTCAGTGCTCTCCTCACCTATCCGTAGGGAAAAGCTGGCTCTCGCCTTGGAAAATGAAGGCTATA TTAAAAAACTATTGCAGCTGTTCCAAGCTTGCGAGAACCTAGAAAACACTGAAGGCTTACACCATTTGTATGAAATTATTAGAGGAATCT TATTCCTAAATAAGGCAACTCTTTTTGAGGTAATGTTTTCTGATGAGTGTATCATGGATGTCGTGGGATGCCTTGAATATGACCCTGCTT TGGCTCAGCCAAAAAGACATAGAGAATTCTTGACCAAAACTGCAAAGTTCAAGGAAGTTATACCAATAACAGACTCTGAACTAAGGCAAA AAATACATCAGACTTACAGGGTACAGTACATTCAGGACATCATTTTGCCCACACCATCTGTTTTTGAAGAGAATTTTCTTTCTACTCTTA CGTCTTTTATTTTCTTCAACAAAGTTGAGATAGTCAGCATGTTGCAGGAAGATGAGAAGTTTTTGTCTGAAGTTTTTGCACAATTAACAG ATGAGGCTACAGATGATGATAAACGGCGTGAATTGGTTAATTTTTTCAAGGAGTTTTGTGCATTTTCTCAGACATTACAACCTCAAAACA GGGATGCATTTTTCAAAACATTGGCAAAATTGGGAATTCTTCCTGCTCTTGAAATTGTAATGGGCATGGATGATTTGCAAGTCAGATCAG CTGCTACAGATATATTTTCTTATCTAGTAGAATTTAGTCCATCTATGGTCCGAGAGTTTGTAATGCAAGAAGCTCAGCAGAGTGATGACG ATATTCTTCTTATTAATGTGGTAATTGAACAAATGATCTGTGATACTGATCCTGAGCTAGGAGGCGCTGTTCAGTTAATGGGACTTCTTC GTACTCTAATTGATCCAGAGAACATGCTGGCTACAACTAATAAAACCGAAAAAAGTGAATTTCTAAATTTTTTCTACAACCATTGTATGC ATGTTCTCACAGCACCACTTTTGACCAATACTTCAGAAGACAAATGTGAAAAGGATAATATAGTTGGATCAAACAAAAACAACACAATTT GTCCCGGTGCCCTTCGCTTTATGAGGCGGATAATTGGACTTAAAGATGAATTTTATAATCGTTACATCACCAAGGGAAATCTTTTTGAGC CAGTTATAAATGCACTTCTGGATAATGGAACTCGGTATAATCTGTTGAATTCAGCTGTTATTGAGTTGTTTGAATTTATAAGAGTGGAAG ATATCAAGTCTCTTACTGCCCATATAGTTGAAAACTTTTATAAAGCACTTGAATCGATTGAATATGTTCAGACATTCAAAGGATTGAAGA CTAAATATGAGCAAGAAAAAGACAGACAAAATCAGAAACTGAACAGTGTACCATCTATATTGCGTAGTAACAGATTTCGCAGAGATGCAA AAGCCTTGGAAGAGGATGAAGAAATGTGGTTTAATGAAGATGAAGAAGAGGAAGGAAAAGCAGTTGTGGCACCAGTGGAAAAACCTAAGC CAGAAGATGATTTTCCAGATAATTATGAAAAGTTTATGGAGACTAAAAAAGCAAAAGAAAGTGAAGACAAGGAAAACCTTCCCAAAAGGA CATCTCCTGGTGGCTTCAAATTTACTTTCTCCCACTCTGCCAGTGCTGCTAATGGAACAAACAGTAAATCTGTAGTGGCTCAGATACCAC CAGCAACTTCTAATGGATCCTCTTCCAAAACCACAAACTTGCCTACGTCAGTAACAGCCACCAAGGGAAGTTTGGTTGGCTTAGTGGATT ATCCAGATGATGAAGAGGAAGATGAAGAAGAAGAATCGTCCCCCAGGAAAAGACCTCGTCTTGGCTCATAAAATATTTATTAGGGGACCC TCAACATGTGGTCTTACAATGCTGCAACTGTTCAGTGAGCTGAAAATCTGAATCAGAAAGCTTTCTCAATTGAACTTATAAAATATACAA GGAGTAGCAAAAGACAGTATATCAGCTAAGAGAGTTTAGTTCTAATAAAAATCAGGCTTCCCAGGAACTTGATTGCTTGCTAGTAATTAA GGGGTTTGCCTTTTAGGCTGTCAAAACAAACATTAGTAACCAGAACCTGGGAGACAGCTTCTCAGCAAGGAAAAGTCACAGGTTTGGGGA CGGTTTAGGGGAGGGGAAAAGGTTGATATAATAATGCAGGGTTGCTCCTCGGGGTGTCGATCTAGAAACAATTTTACAGAACTTCAGTTG TAAACTCAATAACATTACTTGTATAATGGTGCTGGCCATGTTGTTGTTTTAATCAGTTGCCTCTTTTTAAAAGAAATTTTTATGGAAAAC ACATTCAACTATCATTAAAAAAATGAAGTTAAGCTGTTGGGACCATTTCTTTAAGATTTAACAAAAGTTCAGCCTTTTAGGTAGTTGAAG GGAAGTACACCCCGTATTCAGCACATGTTGAGTTTTCTACACCAGGAATTTTCAATATGTATATTGATGAAAACAAGCTCAATTCAAACT GGACAGTTTTAAGATAATGTTAAAATCAGCACTTTTAGAGACAACGAAGGCCAAGAATCAGTACAGTAGTATTCCAAAATGATTTTCTCT AGAAATTTGAAAGTAGATCGAACAGAATGTTGTCAACCGCCTACCAGTACAATCTTTTGTGGAAGATACTTTGAAATCACTTTCTACTTT GTTAGTAAAGTTCTGTCTTTCCAGAGCTGCAAGTTTTAAAGTGTTACTTATACAGACCAACCAAGAATAGTGCTGAATTAAGTGGCATTT AGTATCTAGAAGCCATTTTGATCCAAGAAGCTACTTAAGTGTCAAAGTCAGCATGCAGCACATGTAGCTTTTCTGTAAACAAGGGTGTGA TATGAAAGCTGCTTTTTTAAGAAGAGTAAAAGCACATTCCATATACGTAAGTGAATTTTAAAAATAAATTGAGGCAAACAGTTAAGTTTT ATTTTTAGAGCAACAAGTTAACTGTAAATATTTTAATGTTAGTTTGCTCATCTATGATCTGAGATCATGCCGAAGTGAGAAAAATCTCCC CAAAATACAATTTAATGCATTGGGAAAAAAAAACTTTAACAGTAATTCCAGCCACAATCTTTAGATCACCCTTGTAATGTGTTACGGGTC CATTTTTCCTGGAATCGTTTAATCTAAAGCAGTTTCCCCTGTTTTGGAGATTTTGTAGTTAATTTTAATTTTGGCTATTGTTTGGAAAAG ATGAGCTGTCTGTGTAGATATGAAGTATAGTTTTTTCCATAAAACAGATGTTTATTTTGTATTAAAAAATACCACTGTACTTGTTTTACA CCATTTGTATACATGTGGTGATATTAATGCTAAACTGTAAAATTCAGGAATTAAAATGTGACCCTGTAATTCCATAATTGATGTTTGTGT TTGGTTTGTTGTAAATATAAATTAACTCCATTTTGAGATATGTCAATTTTACAGTATCTTTTAAAAGCCAATAAAATTATCCATAAATAT TTATTATAAACTGCTAGATCATACCCCAATTTTAATGAAATAATTCTAAACAAATGCGGGTCAATGGCACTTTATCAGTGACTACTTATA GAAGGTAAGCCTTGGGGAAATCATAGCATCACAGTATGGAGCTTTTCTCACCTTTTCAATTAAAGGTGTACATATAGTAAGAAAGAAAGA CCTTCCACCTCATAAGGCAGGTGACTCAGGATATTTTAAACTAAGATCAGTAAAGTTCCCATCCACTTTCTTTGAATCATCAAATTTTAT CGAGACCCATCTCTCAGCTTTTAGTAAATTTCTTCTTAAAATAAGCCCACATGTAAAACACTTTCCTAGTTACTTTTTGTTTGTTTGTTT GAGTCTCGCTCTGTTGCCCAGGCTGGAGTGTAGTTGCACGATTTCGGCTTATTGCAACATCCGCCACCTGGGTTCAAGCAATTCTCTGCC TCAGCCTGAGTAGCTGGGATTACAGGTGCCCGTCACCATGCCAGGCTAATTTTTGTATTTTCAGTAGAGACGGGGTTTCACCATCTTGGC CAGGCTGGTCTTAAACTCCTGACCTCACAATCCACCCGCCTCAGCCTCCCTATCTCTGTATCTTATGAAGACTTCCTTTTTCTTTCTGAA GAGCTGCCATAAGTCTTAAACATTTAAATCATCAGAACCTTTTCTTGTAGCAGAAATGTGAATGTTTTCTTGAAGTACAGGTTACGGTTT TCATGGTACAAGTGCTTACCTACGACGATAAGAGAACAAGGCTTAAAATATCCCTCAAAAGAACAATTGTGAGAATTCCATGTTAGCGGC TGTCTTTAAACGACTACCCTCAGGCAGATCTGGGTTTTTATATCTTTATCTTCATTCAGTGAAGCAAGCCAAAAGCCCACATTTGTATGC >55705_55705_1_MTIF2-SMEK2_MTIF2_chr2_55489452_ENST00000394600_SMEK2_chr2_55842642_ENST00000272313_length(amino acids)=840AA_BP=123 MGLQACATTPRRNMNQKLLKLENLLRFHTIYRQLHSLCQRRALRQWRHGFSSAYPVWTAQLCAWPWPTDVLTGAALSQYRLLVTKKEEGP WKSQLSSTKSKKVVEVWIGMTIEELARAMEKNTGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKD PSVEVTQDLIDESEEERFEEMPETSHLIDLPTCELNKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQACENLENTEGLHHL YEIIRGILFLNKATLFEVMFSDECIMDVVGCLEYDPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQYIQDIILPTPSVFE ENFLSTLTSFIFFNKVEIVSMLQEDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLAKLGILPALEIVMGM DDLQVRSAATDIFSYLVEFSPSMVREFVMQEAQQSDDDILLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENMLATTNKTEKSEFLN FFYNHCMHVLTAPLLTNTSEDKCEKDNIVGSNKNNTICPGALRFMRRIIGLKDEFYNRYITKGNLFEPVINALLDNGTRYNLLNSAVIEL FEFIRVEDIKSLTAHIVENFYKALESIEYVQTFKGLKTKYEQEKDRQNQKLNSVPSILRSNRFRRDAKALEEDEEMWFNEDEEEEGKAVV APVEKPKPEDDFPDNYEKFMETKKAKESEDKENLPKRTSPGGFKFTFSHSASAANGTNSKSVVAQIPPATSNGSSSKTTNLPTSVTATKG -------------------------------------------------------------- >55705_55705_2_MTIF2-SMEK2_MTIF2_chr2_55489452_ENST00000394600_SMEK2_chr2_55842642_ENST00000345102_length(transcript)=5008nt_BP=1068nt CGGGGCTGTAGGTAGGAGTTAAGTGGGTAGGATCCCTTAACCAGGGTTGTCCGGTGCAGGTGGTGTGTGTTGTTTCGCCTAACGTGTCAG TGGCACAAATCACGCGAACTTCATAAACATTGTGCGTTCGGAAGCCTTTCCAAGATGCATTTAATCCCTGCGTGAGCCCACGTTAGGCAT TCACGAAGGCATGTGCACTGTTCTCTCGGAAGCGGCTGGCCGGCTTCCCCTCCTCGCGCGCGGCTGTGGGTGCAGGTCCTCACTTCCCAG CCTCCCATGGGCCCAAGGCCTTCTGGGCTCCAATTTGAGGCGAGCCACCCCAGATCCGTAATTTTTCTGCAGTGATTTATTTTTACCTTT CTGATTCCTTGACAAGGATATCCTAGCGGCGAAACAACACCGTACTGGGAGTCAGAACGTCTGGGTTCTAGTCTTGACTGCCATTAACTA GCGGTATGACATTGGAGAAGCTTTTTTGACCCTTCTGGATTTCCGTTTCCTTTTCTGTAAAATGAGGAGCTTGGAAGATCCGGAAAATGA GGCCCATAGGAAACAAGTGACTTGCTGAGTCCAGATAACACTGACTGTCAGAAGTCTCGCTCTGTCTCCCCGGCTGGAGTGCAGTGGCGT GATCTTGGCTCACTGCAACCTCTGTCTCCCGGGTTCAAGAAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCA CCACGCCCAGGAGAAACATGAACCAGAAGCTACTGAAGTTGGAGAACTTGCTACGATTTCACACTATTTATAGGCAACTGCACAGTCTGT GTCAAAGAAGAGCATTAAGACAGTGGAGGCATGGGTTTTCATCTGCTTACCCTGTGTGGACAGCTCAACTGTGTGCCTGGCCCTGGCCAA CAGATGTGCTCACTGGGGCTGCTTTATCTCAGTATAGGCTTCTAGTAACAAAAAAGGAAGAAGGACCATGGAAATCTCAGTTATCTTCAA CAAAATCTAAAAAGGTGGTAGAAGTATGGATTGGAATGACTATTGAGGAACTGGCCAGGGCAATGGAAAAAAACACAGGATCACTACTCT TGGAATCAAAGATAAATCCAAATACTGCATATCAGAAACAACAGGATACATTAATTGTTTGGTCAGAAGCAGAGAACTATGATTTGGCTC TGAGTTTTCAGGAGAAAGCTGGCTGTGATGAGATCTGGGAAAAAATTTGTCAGGTTCAAGGTAAAGACCCATCAGTGGAAGTCACACAGG ACCTCATTGATGAATCTGAAGAAGAACGATTTGAAGAAATGCCTGAAACTAGTCATCTGATTGACCTGCCCACATGTGAACTCAATAAAC TTGAAGAGATTGCTGACTTAGTTACCTCAGTGCTCTCCTCACCTATCCGTAGGGAAAAGCTGGCTCTCGCCTTGGAAAATGAAGGCTATA TTAAAAAACTATTGCAGCTGTTCCAAGCTTGCGAGAACCTAGAAAACACTGAAGGCTTACACCATTTGTATGAAATTATTAGAGGAATCT TATTCCTAAATAAGGCAACTCTTTTTGAGGTAATGTTTTCTGATGAGTGTATCATGGATGTCGTGGGATGCCTTGAATATGACCCTGCTT TGGCTCAGCCAAAAAGACATAGAGAATTCTTGACCAAAACTGCAAAGTTCAAGGAAGTTATACCAATAACAGACTCTGAACTAAGGCAAA AAATACATCAGACTTACAGGGTACAGTACATTCAGGACATCATTTTGCCCACACCATCTGTTTTTGAAGAGAATTTTCTTTCTACTCTTA CGTCTTTTATTTTCTTCAACAAAGTTGAGATAGTCAGCATGTTGCAGGAAGATGAGAAGTTTTTGTCTGAAGTTTTTGCACAATTAACAG ATGAGGCTACAGATGATGATAAACGGCGTGAATTGGTTAATTTTTTCAAGGAGTTTTGTGCATTTTCTCAGACATTACAACCTCAAAACA GGGATGCATTTTTCAAAACATTGGCAAAATTGGGAATTCTTCCTGCTCTTGAAATTGTAATGGGCATGGATGATTTGCAAGTCAGATCAG CTGCTACAGATATATTTTCTTATCTAGTAGAATTTAGTCCATCTATGGTCCGAGAGTTTGTAATGCAAGAAGCTCAGCAGAGTGATGACG ATATTCTTCTTATTAATGTGGTAATTGAACAAATGATCTGTGATACTGATCCTGAGCTAGGAGGCGCTGTTCAGTTAATGGGACTTCTTC GTACTCTAATTGATCCAGAGAACATGCTGGCTACAACTAATAAAACCGAAAAAAGTGAATTTCTAAATTTTTTCTACAACCATTGTATGC ATGTTCTCACAGCACCACTTTTGACCAATACTTCAGAAGACAAATGTGAAAAGGATTTTTTTTTAAAACATTACAGATATAGTTGGAGTT TCATATGTACCCCTTCACATTCCCATTCCCATTCTACCCCCTCTTCCTCCATCTCTCAAGATAATATAGTTGGATCAAACAAAAACAACA CAATTTGTCCCGATAATTATCAAACAGCACAGCTACTTGCCTTAATTTTAGAGTTACTCACATTTTGTGTGGAACATCACACATATCACA TAAAAAACTATATTATGAACAAGGACTTGCTAAGAAGAGTCTTGGTCTTGATGAATTCAAAGCACACTTTTCTGGCCTTGTGTGCCCTTC GCTTTATGAGGCGGATAATTGGACTTAAAGATGAATTTTATAATCGTTACATCACCAAGGGAAATCTTTTTGAGCCAGTTATAAATGCAC TTCTGGATAATGGAACTCGGTATAATCTGTTGAATTCAGCTGTTATTGAGTTGTTTGAATTTATAAGAGTGGAAGATATCAAGTCTCTTA CTGCCCATATAGTTGAAAACTTTTATAAAGCACTTGAATCGATTGAATATGTTCAGACATTCAAAGGATTGAAGACTAAATATGAGCAAG AAAAAGACAGACAAAATCAGAAACTGAACAGTGTACCATCTATATTGCGTAGTAACAGATTTCGCAGAGATGCAAAAGCCTTGGAAGAGG ATGAAGAAATGTGGTTTAATGAAGATGAAGAAGAGGAAGGAAAAGCAGTTGTGGCACCAGTGGAAAAACCTAAGCCAGAAGATGATTTTC CAGATAATTATGAAAAGTTTATGGAGACTAAAAAAGCAAAAGAAAGTGAAGACAAGGAAAACCTTCCCAAAAGGACATCTCCTGGTGGCT TCAAATTTACTTTCTCCCACTCTGCCAGTGCTGCTAATGGAACAAACAGTAAATCTGTAGTGGCTCAGATACCACCAGCAACTTCTAATG GATCCTCTTCCAAAACCACAAACTTGCCTACGTCAGTAACAGCCACCAAGGGAAGTTTGGTTGGCTTAGTGGATTATCCAGATGATGAAG AGGAAGATGAAGAAGAAGAATCGTCCCCCAGGAAAAGACCTCGTCTTGGCTCATAAAATATTTATTAGGGGACCCTCAACATGTGGTCTT ACAATGCTGCAACTGTTCAGTGAGCTGAAAATCTGAATCAGAAAGCTTTCTCAATTGAACTTATAAAATATACAAGGAGTAGCAAAAGAC AGTATATCAGCTAAGAGAGTTTAGTTCTAATAAAAATCAGGCTTCCCAGGAACTTGATTGCTTGCTAGTAATTAAGGGGTTTGCCTTTTA GGCTGTCAAAACAAACATTAGTAACCAGAACCTGGGAGACAGCTTCTCAGCAAGGAAAAGTCACAGGTTTGGGGACGGTTTAGGGGAGGG GAAAAGGTTGATATAATAATGCAGGGTTGCTCCTCGGGGTGTCGATCTAGAAACAATTTTACAGAACTTCAGTTGTAAACTCAATAACAT TACTTGTATAATGGTGCTGGCCATGTTGTTGTTTTAATCAGTTGCCTCTTTTTAAAAGAAATTTTTATGGAAAACACATTCAACTATCAT TAAAAAAATGAAGTTAAGCTGTTGGGACCATTTCTTTAAGATTTAACAAAAGTTCAGCCTTTTAGGTAGTTGAAGGGAAGTACACCCCGT ATTCAGCACATGTTGAGTTTTCTACACCAGGAATTTTCAATATGTATATTGATGAAAACAAGCTCAATTCAAACTGGACAGTTTTAAGAT AATGTTAAAATCAGCACTTTTAGAGACAACGAAGGCCAAGAATCAGTACAGTAGTATTCCAAAATGATTTTCTCTAGAAATTTGAAAGTA GATCGAACAGAATGTTGTCAACCGCCTACCAGTACAATCTTTTGTGGAAGATACTTTGAAATCACTTTCTACTTTGTTAGTAAAGTTCTG TCTTTCCAGAGCTGCAAGTTTTAAAGTGTTACTTATACAGACCAACCAAGAATAGTGCTGAATTAAGTGGCATTTAGTATCTAGAAGCCA TTTTGATCCAAGAAGCTACTTAAGTGTCAAAGTCAGCATGCAGCACATGTAGCTTTTCTGTAAACAAGGGTGTGATATGAAAGCTGCTTT TTTAAGAAGAGTAAAAGCACATTCCATATACGTAAGTGAATTTTAAAAATAAATTGAGGCAAACAGTTAAGTTTTATTTTTAGAGCAACA AGTTAACTGTAAATATTTTAATGTTAGTTTGCTCATCTATGATCTGAGATCATGCCGAAGTGAGAAAAATCTCCCCAAAATACAATTTAA TGCATTGGGAAAAAAAAACTTTAACAGTAATTCCAGCCACAATCTTTAGATCACCCTTGTAATGTGTTACGGGTCCATTTTTCCTGGAAT CGTTTAATCTAAAGCAGTTTCCCCTGTTTTGGAGATTTTGTAGTTAATTTTAATTTTGGCTATTGTTTGGAAAAGATGAGCTGTCTGTGT AGATATGAAGTATAGTTTTTTCCATAAAACAGATGTTTATTTTGTATTAAAAAATACCACTGTACTTGTTTTACACCATTTGTATACATG >55705_55705_2_MTIF2-SMEK2_MTIF2_chr2_55489452_ENST00000394600_SMEK2_chr2_55842642_ENST00000345102_length(amino acids)=925AA_BP=123 MGLQACATTPRRNMNQKLLKLENLLRFHTIYRQLHSLCQRRALRQWRHGFSSAYPVWTAQLCAWPWPTDVLTGAALSQYRLLVTKKEEGP WKSQLSSTKSKKVVEVWIGMTIEELARAMEKNTGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKD PSVEVTQDLIDESEEERFEEMPETSHLIDLPTCELNKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQACENLENTEGLHHL YEIIRGILFLNKATLFEVMFSDECIMDVVGCLEYDPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQYIQDIILPTPSVFE ENFLSTLTSFIFFNKVEIVSMLQEDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLAKLGILPALEIVMGM DDLQVRSAATDIFSYLVEFSPSMVREFVMQEAQQSDDDILLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENMLATTNKTEKSEFLN FFYNHCMHVLTAPLLTNTSEDKCEKDFFLKHYRYSWSFICTPSHSHSHSTPSSSISQDNIVGSNKNNTICPDNYQTAQLLALILELLTFC VEHHTYHIKNYIMNKDLLRRVLVLMNSKHTFLALCALRFMRRIIGLKDEFYNRYITKGNLFEPVINALLDNGTRYNLLNSAVIELFEFIR VEDIKSLTAHIVENFYKALESIEYVQTFKGLKTKYEQEKDRQNQKLNSVPSILRSNRFRRDAKALEEDEEMWFNEDEEEEGKAVVAPVEK PKPEDDFPDNYEKFMETKKAKESEDKENLPKRTSPGGFKFTFSHSASAANGTNSKSVVAQIPPATSNGSSSKTTNLPTSVTATKGSLVGL -------------------------------------------------------------- >55705_55705_3_MTIF2-SMEK2_MTIF2_chr2_55489452_ENST00000394600_SMEK2_chr2_55842642_ENST00000407823_length(transcript)=4913nt_BP=1068nt CGGGGCTGTAGGTAGGAGTTAAGTGGGTAGGATCCCTTAACCAGGGTTGTCCGGTGCAGGTGGTGTGTGTTGTTTCGCCTAACGTGTCAG TGGCACAAATCACGCGAACTTCATAAACATTGTGCGTTCGGAAGCCTTTCCAAGATGCATTTAATCCCTGCGTGAGCCCACGTTAGGCAT TCACGAAGGCATGTGCACTGTTCTCTCGGAAGCGGCTGGCCGGCTTCCCCTCCTCGCGCGCGGCTGTGGGTGCAGGTCCTCACTTCCCAG CCTCCCATGGGCCCAAGGCCTTCTGGGCTCCAATTTGAGGCGAGCCACCCCAGATCCGTAATTTTTCTGCAGTGATTTATTTTTACCTTT CTGATTCCTTGACAAGGATATCCTAGCGGCGAAACAACACCGTACTGGGAGTCAGAACGTCTGGGTTCTAGTCTTGACTGCCATTAACTA GCGGTATGACATTGGAGAAGCTTTTTTGACCCTTCTGGATTTCCGTTTCCTTTTCTGTAAAATGAGGAGCTTGGAAGATCCGGAAAATGA GGCCCATAGGAAACAAGTGACTTGCTGAGTCCAGATAACACTGACTGTCAGAAGTCTCGCTCTGTCTCCCCGGCTGGAGTGCAGTGGCGT GATCTTGGCTCACTGCAACCTCTGTCTCCCGGGTTCAAGAAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCA CCACGCCCAGGAGAAACATGAACCAGAAGCTACTGAAGTTGGAGAACTTGCTACGATTTCACACTATTTATAGGCAACTGCACAGTCTGT GTCAAAGAAGAGCATTAAGACAGTGGAGGCATGGGTTTTCATCTGCTTACCCTGTGTGGACAGCTCAACTGTGTGCCTGGCCCTGGCCAA CAGATGTGCTCACTGGGGCTGCTTTATCTCAGTATAGGCTTCTAGTAACAAAAAAGGAAGAAGGACCATGGAAATCTCAGTTATCTTCAA CAAAATCTAAAAAGGTGGTAGAAGTATGGATTGGAATGACTATTGAGGAACTGGCCAGGGCAATGGAAAAAAACACAGGATCACTACTCT TGGAATCAAAGATAAATCCAAATACTGCATATCAGAAACAACAGGATACATTAATTGTTTGGTCAGAAGCAGAGAACTATGATTTGGCTC TGAGTTTTCAGGAGAAAGCTGGCTGTGATGAGATCTGGGAAAAAATTTGTCAGGTTCAAGGTAAAGACCCATCAGTGGAAGTCACACAGG ACCTCATTGATGAATCTGAAGAAGAACGATTTGAAGAAATGCCTGAAACTAGTCATCTGATTGACCTGCCCACATGTGAACTCAATAAAC TTGAAGAGATTGCTGACTTAGTTACCTCAGTGCTCTCCTCACCTATCCGTAGGGAAAAGCTGGCTCTCGCCTTGGAAAATGAAGGCTATA TTAAAAAACTATTGCAGCTGTTCCAAGCTTGCGAGAACCTAGAAAACACTGAAGGCTTACACCATTTGTATGAAATTATTAGAGGAATCT TATTCCTAAATAAGGCAACTCTTTTTGAGGTAATGTTTTCTGATGAGTGTATCATGGATGTCGTGGGATGCCTTGAATATGACCCTGCTT TGGCTCAGCCAAAAAGACATAGAGAATTCTTGACCAAAACTGCAAAGTTCAAGGAAGTTATACCAATAACAGACTCTGAACTAAGGCAAA AAATACATCAGACTTACAGGGTACAGTACATTCAGGACATCATTTTGCCCACACCATCTGTTTTTGAAGAGAATTTTCTTTCTACTCTTA CGTCTTTTATTTTCTTCAACAAAGTTGAGATAGTCAGCATGTTGCAGGAAGATGAGAAGTTTTTGTCTGAAGTTTTTGCACAATTAACAG ATGAGGCTACAGATGATGATAAACGGCGTGAATTGGTTAATTTTTTCAAGGAGTTTTGTGCATTTTCTCAGACATTACAACCTCAAAACA GGGATGCATTTTTCAAAACATTGGCAAAATTGGGAATTCTTCCTGCTCTTGAAATTGTAATGGGCATGGATGATTTGCAAGTCAGATCAG CTGCTACAGATATATTTTCTTATCTAGTAGAATTTAGTCCATCTATGGTCCGAGAGTTTGTAATGCAAGAAGCTCAGCAGAGTGATGACG ATATTCTTCTTATTAATGTGGTAATTGAACAAATGATCTGTGATACTGATCCTGAGCTAGGAGGCGCTGTTCAGTTAATGGGACTTCTTC GTACTCTAATTGATCCAGAGAACATGCTGGCTACAACTAATAAAACCGAAAAAAGTGAATTTCTAAATTTTTTCTACAACCATTGTATGC ATGTTCTCACAGCACCACTTTTGACCAATACTTCAGAAGACAAATGTGAAAAGGATAATATAGTTGGATCAAACAAAAACAACACAATTT GTCCCGATAATTATCAAACAGCACAGCTACTTGCCTTAATTTTAGAGTTACTCACATTTTGTGTGGAACATCACACATATCACATAAAAA ACTATATTATGAACAAGGACTTGCTAAGAAGAGTCTTGGTCTTGATGAATTCAAAGCACACTTTTCTGGCCTTGTGTGCCCTTCGCTTTA TGAGGCGGATAATTGGACTTAAAGATGAATTTTATAATCGTTACATCACCAAGGGAAATCTTTTTGAGCCAGTTATAAATGCACTTCTGG ATAATGGAACTCGGTATAATCTGTTGAATTCAGCTGTTATTGAGTTGTTTGAATTTATAAGAGTGGAAGATATCAAGTCTCTTACTGCCC ATATAGTTGAAAACTTTTATAAAGCACTTGAATCGATTGAATATGTTCAGACATTCAAAGGATTGAAGACTAAATATGAGCAAGAAAAAG ACAGACAAAATCAGAAACTGAACAGTGTACCATCTATATTGCGTAGTAACAGATTTCGCAGAGATGCAAAAGCCTTGGAAGAGGATGAAG AAATGTGGTTTAATGAAGATGAAGAAGAGGAAGGAAAAGCAGTTGTGGCACCAGTGGAAAAACCTAAGCCAGAAGATGATTTTCCAGATA ATTATGAAAAGTTTATGGAGACTAAAAAAGCAAAAGAAAGTGAAGACAAGGAAAACCTTCCCAAAAGGACATCTCCTGGTGGCTTCAAAT TTACTTTCTCCCACTCTGCCAGTGCTGCTAATGGAACAAACAGTAAATCTGTAGTGGCTCAGATACCACCAGCAACTTCTAATGGATCCT CTTCCAAAACCACAAACTTGCCTACGTCAGTAACAGCCACCAAGGGAAGTTTGGTTGGCTTAGTGGATTATCCAGATGATGAAGAGGAAG ATGAAGAAGAAGAATCGTCCCCCAGGAAAAGACCTCGTCTTGGCTCATAAAATATTTATTAGGGGACCCTCAACATGTGGTCTTACAATG CTGCAACTGTTCAGTGAGCTGAAAATCTGAATCAGAAAGCTTTCTCAATTGAACTTATAAAATATACAAGGAGTAGCAAAAGACAGTATA TCAGCTAAGAGAGTTTAGTTCTAATAAAAATCAGGCTTCCCAGGAACTTGATTGCTTGCTAGTAATTAAGGGGTTTGCCTTTTAGGCTGT CAAAACAAACATTAGTAACCAGAACCTGGGAGACAGCTTCTCAGCAAGGAAAAGTCACAGGTTTGGGGACGGTTTAGGGGAGGGGAAAAG GTTGATATAATAATGCAGGGTTGCTCCTCGGGGTGTCGATCTAGAAACAATTTTACAGAACTTCAGTTGTAAACTCAATAACATTACTTG TATAATGGTGCTGGCCATGTTGTTGTTTTAATCAGTTGCCTCTTTTTAAAAGAAATTTTTATGGAAAACACATTCAACTATCATTAAAAA AATGAAGTTAAGCTGTTGGGACCATTTCTTTAAGATTTAACAAAAGTTCAGCCTTTTAGGTAGTTGAAGGGAAGTACACCCCGTATTCAG CACATGTTGAGTTTTCTACACCAGGAATTTTCAATATGTATATTGATGAAAACAAGCTCAATTCAAACTGGACAGTTTTAAGATAATGTT AAAATCAGCACTTTTAGAGACAACGAAGGCCAAGAATCAGTACAGTAGTATTCCAAAATGATTTTCTCTAGAAATTTGAAAGTAGATCGA ACAGAATGTTGTCAACCGCCTACCAGTACAATCTTTTGTGGAAGATACTTTGAAATCACTTTCTACTTTGTTAGTAAAGTTCTGTCTTTC CAGAGCTGCAAGTTTTAAAGTGTTACTTATACAGACCAACCAAGAATAGTGCTGAATTAAGTGGCATTTAGTATCTAGAAGCCATTTTGA TCCAAGAAGCTACTTAAGTGTCAAAGTCAGCATGCAGCACATGTAGCTTTTCTGTAAACAAGGGTGTGATATGAAAGCTGCTTTTTTAAG AAGAGTAAAAGCACATTCCATATACGTAAGTGAATTTTAAAAATAAATTGAGGCAAACAGTTAAGTTTTATTTTTAGAGCAACAAGTTAA CTGTAAATATTTTAATGTTAGTTTGCTCATCTATGATCTGAGATCATGCCGAAGTGAGAAAAATCTCCCCAAAATACAATTTAATGCATT GGGAAAAAAAAACTTTAACAGTAATTCCAGCCACAATCTTTAGATCACCCTTGTAATGTGTTACGGGTCCATTTTTCCTGGAATCGTTTA ATCTAAAGCAGTTTCCCCTGTTTTGGAGATTTTGTAGTTAATTTTAATTTTGGCTATTGTTTGGAAAAGATGAGCTGTCTGTGTAGATAT GAAGTATAGTTTTTTCCATAAAACAGATGTTTATTTTGTATTAAAAAATACCACTGTACTTGTTTTACACCATTTGTATACATGTGGTGA >55705_55705_3_MTIF2-SMEK2_MTIF2_chr2_55489452_ENST00000394600_SMEK2_chr2_55842642_ENST00000407823_length(amino acids)=893AA_BP=123 MGLQACATTPRRNMNQKLLKLENLLRFHTIYRQLHSLCQRRALRQWRHGFSSAYPVWTAQLCAWPWPTDVLTGAALSQYRLLVTKKEEGP WKSQLSSTKSKKVVEVWIGMTIEELARAMEKNTGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKD PSVEVTQDLIDESEEERFEEMPETSHLIDLPTCELNKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQACENLENTEGLHHL YEIIRGILFLNKATLFEVMFSDECIMDVVGCLEYDPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQYIQDIILPTPSVFE ENFLSTLTSFIFFNKVEIVSMLQEDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLAKLGILPALEIVMGM DDLQVRSAATDIFSYLVEFSPSMVREFVMQEAQQSDDDILLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENMLATTNKTEKSEFLN FFYNHCMHVLTAPLLTNTSEDKCEKDNIVGSNKNNTICPDNYQTAQLLALILELLTFCVEHHTYHIKNYIMNKDLLRRVLVLMNSKHTFL ALCALRFMRRIIGLKDEFYNRYITKGNLFEPVINALLDNGTRYNLLNSAVIELFEFIRVEDIKSLTAHIVENFYKALESIEYVQTFKGLK TKYEQEKDRQNQKLNSVPSILRSNRFRRDAKALEEDEEMWFNEDEEEEGKAVVAPVEKPKPEDDFPDNYEKFMETKKAKESEDKENLPKR -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for MTIF2-SMEK2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MTIF2-SMEK2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MTIF2-SMEK2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |