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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NFATC2-DOK5 (FusionGDB2 ID:HG4773TG55816)

Fusion Gene Summary for NFATC2-DOK5

check button Fusion gene summary
Fusion gene informationFusion gene name: NFATC2-DOK5
Fusion gene ID: hg4773tg55816
HgeneTgene
Gene symbol

NFATC2

DOK5

Gene ID

4773

55816

Gene namenuclear factor of activated T cells 2docking protein 5
SynonymsNFAT1|NFATPC20orf180|IRS-6|IRS6
Cytomap('NFATC2')('DOK5')

20q13.2

20q13.2

Type of geneprotein-codingprotein-coding
Descriptionnuclear factor of activated T-cells, cytoplasmic 2NF-ATc2NFAT pre-existing subunitNFAT transcription complex, preexisting componentT cell transcription factor NFAT1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2nuclear factdocking protein 5downstream of tyrosine kinase 5insulin receptor substrate 6
Modification date2020032920200320
UniProtAcc

Q13469

.
Ensembl transtripts involved in fusion geneENST00000371564, ENST00000396009, 
ENST00000414705, ENST00000609507, 
ENST00000609943, ENST00000610033, 
Fusion gene scores* DoF score9 X 9 X 5=40511 X 9 X 8=792
# samples 812
** MAII scorelog2(8/405*10)=-2.33985000288462
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/792*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NFATC2 [Title/Abstract] AND DOK5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNFATC2(50133323)-DOK5(53171472), # samples:2
Anticipated loss of major functional domain due to fusion event.NFATC2-DOK5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NFATC2-DOK5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NFATC2-DOK5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NFATC2-DOK5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NFATC2-DOK5 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NFATC2-DOK5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NFATC2-DOK5 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
NFATC2-DOK5 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFATC2

GO:0016477

cell migration

21871017

HgeneNFATC2

GO:0045893

positive regulation of transcription, DNA-templated

15790681

HgeneNFATC2

GO:1905064

negative regulation of vascular smooth muscle cell differentiation

23853098


check buttonFusion gene breakpoints across NFATC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across DOK5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EE-A2MH-06ANFATC2chr20

50133323

-DOK5chr20

53171472

+


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Fusion Gene ORF analysis for NFATC2-DOK5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000371564ENST00000395939NFATC2chr20

50133323

-DOK5chr20

53171472

+
5CDS-5UTRENST00000396009ENST00000395939NFATC2chr20

50133323

-DOK5chr20

53171472

+
5CDS-5UTRENST00000414705ENST00000395939NFATC2chr20

50133323

-DOK5chr20

53171472

+
5CDS-5UTRENST00000609507ENST00000395939NFATC2chr20

50133323

-DOK5chr20

53171472

+
5CDS-5UTRENST00000609943ENST00000395939NFATC2chr20

50133323

-DOK5chr20

53171472

+
5CDS-5UTRENST00000610033ENST00000395939NFATC2chr20

50133323

-DOK5chr20

53171472

+
5CDS-intronENST00000371564ENST00000491469NFATC2chr20

50133323

-DOK5chr20

53171472

+
5CDS-intronENST00000396009ENST00000491469NFATC2chr20

50133323

-DOK5chr20

53171472

+
5CDS-intronENST00000414705ENST00000491469NFATC2chr20

50133323

-DOK5chr20

53171472

+
5CDS-intronENST00000609507ENST00000491469NFATC2chr20

50133323

-DOK5chr20

53171472

+
5CDS-intronENST00000609943ENST00000491469NFATC2chr20

50133323

-DOK5chr20

53171472

+
5CDS-intronENST00000610033ENST00000491469NFATC2chr20

50133323

-DOK5chr20

53171472

+
Frame-shiftENST00000371564ENST00000262593NFATC2chr20

50133323

-DOK5chr20

53171472

+
Frame-shiftENST00000414705ENST00000262593NFATC2chr20

50133323

-DOK5chr20

53171472

+
In-frameENST00000396009ENST00000262593NFATC2chr20

50133323

-DOK5chr20

53171472

+
In-frameENST00000609507ENST00000262593NFATC2chr20

50133323

-DOK5chr20

53171472

+
In-frameENST00000609943ENST00000262593NFATC2chr20

50133323

-DOK5chr20

53171472

+
In-frameENST00000610033ENST00000262593NFATC2chr20

50133323

-DOK5chr20

53171472

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000396009NFATC2chr2050133323-ENST00000262593DOK5chr2053171472+309915522112406731
ENST00000609943NFATC2chr2050133323-ENST00000262593DOK5chr2053171472+302114742022328708
ENST00000610033NFATC2chr2050133323-ENST00000262593DOK5chr2053171472+258510383631892509
ENST00000609507NFATC2chr2050133323-ENST00000262593DOK5chr2053171472+25079602341814526

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000396009ENST00000262593NFATC2chr2050133323-DOK5chr2053171472+0.0146426690.98535734
ENST00000609943ENST00000262593NFATC2chr2050133323-DOK5chr2053171472+0.0183914580.98160857
ENST00000610033ENST00000262593NFATC2chr2050133323-DOK5chr2053171472+0.0339680540.96603197
ENST00000609507ENST00000262593NFATC2chr2050133323-DOK5chr2053171472+0.0278495230.9721505

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Fusion Genomic Features for NFATC2-DOK5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NFATC2chr2050133322-DOK5chr2053171471+0.0003439310.9996561
NFATC2chr2050133322-DOK5chr2053171471+0.0003439310.9996561

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NFATC2-DOK5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:50133323/chr20:53171472)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFATC2

Q13469

.
FUNCTION: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway. {ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFATC2chr20:50133323chr20:53171472ENST00000371564-311421_4284441989.6666666666667DNA binding.
HgeneNFATC2chr20:50133323chr20:53171472ENST00000396009-310421_428444926.0DNA binding.
HgeneNFATC2chr20:50133323chr20:53171472ENST00000371564-311251_2534441989.6666666666667MotifNote=Nuclear localization signal
HgeneNFATC2chr20:50133323chr20:53171472ENST00000371564-31126_344441989.6666666666667MotifNote=9aaTAD
HgeneNFATC2chr20:50133323chr20:53171472ENST00000396009-310251_253444926.0MotifNote=Nuclear localization signal
HgeneNFATC2chr20:50133323chr20:53171472ENST00000396009-31026_34444926.0MotifNote=9aaTAD
HgeneNFATC2chr20:50133323chr20:53171472ENST00000414705-311251_253424639.3333333333334MotifNote=Nuclear localization signal
HgeneNFATC2chr20:50133323chr20:53171472ENST00000414705-31126_34424639.3333333333334MotifNote=9aaTAD
HgeneNFATC2chr20:50133323chr20:53171472ENST00000371564-311111_1164441989.6666666666667RegionCalcineurin-binding
HgeneNFATC2chr20:50133323chr20:53171472ENST00000371564-311119_1994441989.6666666666667RegionNote=Trans-activation domain A (TAD-A)
HgeneNFATC2chr20:50133323chr20:53171472ENST00000371564-311161_1754441989.6666666666667RegionRequired for cytoplasmic retention of the phosphorylated form
HgeneNFATC2chr20:50133323chr20:53171472ENST00000371564-311184_2864441989.6666666666667RegionNote=3 X approximate SP repeats
HgeneNFATC2chr20:50133323chr20:53171472ENST00000396009-310111_116444926.0RegionCalcineurin-binding
HgeneNFATC2chr20:50133323chr20:53171472ENST00000396009-310119_199444926.0RegionNote=Trans-activation domain A (TAD-A)
HgeneNFATC2chr20:50133323chr20:53171472ENST00000396009-310161_175444926.0RegionRequired for cytoplasmic retention of the phosphorylated form
HgeneNFATC2chr20:50133323chr20:53171472ENST00000396009-310184_286444926.0RegionNote=3 X approximate SP repeats
HgeneNFATC2chr20:50133323chr20:53171472ENST00000414705-311111_116424639.3333333333334RegionCalcineurin-binding
HgeneNFATC2chr20:50133323chr20:53171472ENST00000414705-311119_199424639.3333333333334RegionNote=Trans-activation domain A (TAD-A)
HgeneNFATC2chr20:50133323chr20:53171472ENST00000414705-311161_175424639.3333333333334RegionRequired for cytoplasmic retention of the phosphorylated form
HgeneNFATC2chr20:50133323chr20:53171472ENST00000414705-311184_286424639.3333333333334RegionNote=3 X approximate SP repeats
HgeneNFATC2chr20:50133323chr20:53171472ENST00000371564-311184_2004441989.6666666666667RepeatNote=1
HgeneNFATC2chr20:50133323chr20:53171472ENST00000371564-311213_2294441989.6666666666667RepeatNote=2
HgeneNFATC2chr20:50133323chr20:53171472ENST00000371564-311272_2864441989.6666666666667RepeatNote=3%3B approximate
HgeneNFATC2chr20:50133323chr20:53171472ENST00000396009-310184_200444926.0RepeatNote=1
HgeneNFATC2chr20:50133323chr20:53171472ENST00000396009-310213_229444926.0RepeatNote=2
HgeneNFATC2chr20:50133323chr20:53171472ENST00000396009-310272_286444926.0RepeatNote=3%3B approximate
HgeneNFATC2chr20:50133323chr20:53171472ENST00000414705-311184_200424639.3333333333334RepeatNote=1
HgeneNFATC2chr20:50133323chr20:53171472ENST00000414705-311213_229424639.3333333333334RepeatNote=2
HgeneNFATC2chr20:50133323chr20:53171472ENST00000414705-311272_286424639.3333333333334RepeatNote=3%3B approximate
TgeneDOK5chr20:50133323chr20:53171472ENST0000026259308132_23722307.0DomainIRS-type PTB
TgeneDOK5chr20:50133323chr20:53171472ENST0000039593908132_2370199.0DomainIRS-type PTB
TgeneDOK5chr20:50133323chr20:53171472ENST00000395939088_1120199.0DomainNote=PH
TgeneDOK5chr20:50133323chr20:53171472ENST0000026259308263_27322307.0MotifNote=DKFBH motif
TgeneDOK5chr20:50133323chr20:53171472ENST0000039593908263_2730199.0MotifNote=DKFBH motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFATC2chr20:50133323chr20:53171472ENST00000414705-311421_428424639.3333333333334DNA binding.
HgeneNFATC2chr20:50133323chr20:53171472ENST00000371564-311392_5744441989.6666666666667DomainRHD
HgeneNFATC2chr20:50133323chr20:53171472ENST00000396009-310392_574444926.0DomainRHD
HgeneNFATC2chr20:50133323chr20:53171472ENST00000414705-311392_574424639.3333333333334DomainRHD
HgeneNFATC2chr20:50133323chr20:53171472ENST00000371564-311664_6664441989.6666666666667MotifNote=Nuclear localization signal
HgeneNFATC2chr20:50133323chr20:53171472ENST00000371564-311904_9134441989.6666666666667MotifNote=Nuclear export signal
HgeneNFATC2chr20:50133323chr20:53171472ENST00000396009-310664_666444926.0MotifNote=Nuclear localization signal
HgeneNFATC2chr20:50133323chr20:53171472ENST00000396009-310904_913444926.0MotifNote=Nuclear export signal
HgeneNFATC2chr20:50133323chr20:53171472ENST00000414705-311664_666424639.3333333333334MotifNote=Nuclear localization signal
HgeneNFATC2chr20:50133323chr20:53171472ENST00000414705-311904_913424639.3333333333334MotifNote=Nuclear export signal
TgeneDOK5chr20:50133323chr20:53171472ENST00000262593088_11222307.0DomainNote=PH


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Fusion Gene Sequence for NFATC2-DOK5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>58789_58789_1_NFATC2-DOK5_NFATC2_chr20_50133323_ENST00000396009_DOK5_chr20_53171472_ENST00000262593_length(transcript)=3099nt_BP=1552nt
AGCAGGAAGCTCGCGCCGCCGTCGCCGCCGCCGCTCAGCTTCCCCGGGCGCGTCCAGGACCCGCTGCGCCAGGCGCGCCGTCCCCGGACC
CGGCGTGCGTCCCTACGAGGAAAGGGACCCCGCCGCTCGAGCCGCCTCCGCCAGCCCCACTGCGAGGGGTCCCAGAGCCAGCCGCGCCCG
CCCTCGCCCCCGGCCCCGCAGCCTTCCCGCCCTGCGCGCCATGAACGCCCCCGAGCGGCAGCCCCAACCCGACGGCGGGGACGCCCCAGG
CCACGAGCCTGGGGGCAGCCCCCAAGACGAGCTTGACTTCTCCATCCTCTTCGACTATGAGTATTTGAATCCGAACGAAGAAGAGCCGAA
TGCACATAAGGTCGCCAGCCCACCCTCCGGACCCGCATACCCCGATGATGTCCTGGACTATGGCCTCAAGCCATACAGCCCCCTTGCTAG
TCTCTCTGGCGAGCCCCCCGGCCGATTCGGAGAGCCGGATAGGGTAGGGCCGCAGAAGTTTCTGAGCGCGGCCAAGCCAGCAGGGGCCTC
GGGCCTGAGCCCTCGGATCGAGATCACTCCGTCCCACGAACTGATCCAGGCAGTGGGGCCCCTCCGCATGAGAGACGCGGGCCTCCTGGT
GGAGCAGCCGCCCCTGGCCGGGGTGGCCGCCAGCCCGAGGTTCACCCTGCCCGTGCCCGGCTTCGAGGGCTACCGCGAGCCGCTTTGCTT
GAGCCCCGCTAGCAGCGGCTCCTCTGCCAGCTTCATTTCTGACACCTTCTCCCCCTACACCTCGCCCTGCGTCTCGCCCAATAACGGCGG
GCCCGACGACCTGTGTCCGCAGTTTCAAAACATCCCTGCTCATTATTCCCCCAGAACCTCGCCAATAATGTCACCTCGAACCAGCCTCGC
CGAGGACAGCTGCCTGGGCCGCCACTCGCCCGTGCCCCGTCCGGCCTCCCGCTCCTCATCGCCTGGTGCCAAGCGGAGGCATTCGTGCGC
CGAGGCCTTGGTTGCCCTGCCGCCCGGAGCCTCACCCCAGCGCTCCCGGAGCCCCTCGCCGCAGCCCTCATCTCACGTGGCACCCCAGGA
CCACGGCTCCCCGGCTGGGTACCCCCCTGTGGCTGGCTCTGCCGTGATCATGGATGCCCTGAACAGCCTCGCCACGGACTCGCCTTGTGG
GATCCCCCCCAAGATGTGGAAGACCAGCCCTGACCCCTCGCCGGTGTCTGCCGCCCCATCCAAGGCCGGCCTGCCTCGCCACATCTACCC
GGCCGTGGAGTTCCTGGGGCCCTGCGAGCAGGGCGAGAGGAGAAACTCGGCTCCAGAATCCATCCTGCTGGTTCCGCCCACTTGGCCCAA
GCCGCTGGTGCCTGCCATTCCCATCTGCAGCATCCCAGTGACTGCATCCCTCCCTCCACTTGAGTGGCCGCTGTCCAGTCAGTCAGGCTC
TTACGAGCTGCGGATCGAGGTGCAGCCCAAGCCACATCACCGGGCCCACTATGAGACAGAAGGCAGCCGAGGGGCTGTCAAAGCTCCAAC
TGGAGGCCACCCTGTGGTTCAGATTTATCAGCGATGCTGGTTAGTATTCAAGAAAGCTTCAAGCAAAGGTCCAAAAAGACTGGAGAAATT
TTCTGATGAACGTGCTGCATATTTCAGGTGTTATCATAAGGTTACAGAACTCAATAATGTGAAGAACGTAGCTCGATTGCCAAAAAGCAC
CAAGAAACATGCCATAGGGATTTATTTCAATGACGATACCTCCAAGACTTTTGCTTGCGAATCAGATCTTGAGGCTGATGAGTGGTGCAA
AGTACTCCAGATGGAGTGTGTAGGAACACGGATCAATGACATCAGCCTTGGAGAGCCTGACTTACTGGCCACTGGGGTTGAGAGAGAACA
GAGTGAGAGATTCAATGTGTATTTGATGCCATCTCCTAACTTAGATGTACATGGCGAATGTGCCTTGCAGATTACATATGAGTATATCTG
TCTTTGGGACGTCCAGAATCCCAGAGTCAAACTCATCTCTTGGCCGCTAAGCGCCCTGCGGCGGTATGGACGTGATACTACGTGGTTCAC
TTTTGAGGCAGGGAGGATGTGTGAGACTGGTGAAGGGCTGTTTATCTTTCAGACCCGAGACGGGGAGGCCATCTATCAGAAAGTCCACTC
TGCTGCCTTGGCCATAGCCGAGCAGCACGAGCGCTTGCTACAGAGTGTGAAAAACTCGATGCTCCAGATGAAGATGAGTGAGCGGGCCGC
CTCGCTGAGCACCATGGTGCCCCTGCCTCGCAGCGCCTACTGGCAGCACATCACACGGCAGCACAGCACGGGACAGCTCTACCGCTTGCA
AGATGTTTCCAGCCCTCTGAAGCTTCATCGAACAGAGACTTTTCCAGCCTACAGATCTGAGCACTGACAGTAACTGCCAAGAATTGTTAA
CACACTTGTGATGTGTCAGCCACAGATTCACCCAGGAGGTCACAGAATGACAGCAAGGGAAATGACGACCAAGAGAAGAAGCTTAAAGTC
CTGGCTAATTGTGTGGTCATTGGAAAACTCTGCAATACAATAATTTTCTTTATTTTCTTTTTCTTTTTTAAATTCTTAGTGTAATTGAAA
CGTGCTCTATAGATATTGACTCTGTGTTCCCTCTTTTACAGCTGGACAGAAAGAAGTCAATGTCACGAAATGATTTTCTATTGTAGATAC
TTTGTCCCTTGCACTTCTCTGAATCTGTCCTTTTGTGGATTCTTGTGATTTTCCTTCCAAGTGTTTCAGTTGTATGACAGTCAGTATTGA
CAATAAAATGGCTTTTAATTATTTGTTATTTGTTTACACCCTATTCCTCAGTTATTATTACTGTGGTTCTGATTAACTACTGGAAATTAT
ATTTGATTATATCACCAATTAGTTAAATCAGTGCTTCGACTCACTCTTATCTGTTCTGTTCAAAACTATTTGTTCAAAGAACCCGTTAGT
GTTGTTTACAGGGTTACAGTTTCTCTCACATGCTTTCCTCACCCCTTTACCCCCCTTTTTGAAAGCCTTTATTTTGTTCGGAGTCTCTTC

>58789_58789_1_NFATC2-DOK5_NFATC2_chr20_50133323_ENST00000396009_DOK5_chr20_53171472_ENST00000262593_length(amino acids)=731AA_BP=446
MRAMNAPERQPQPDGGDAPGHEPGGSPQDELDFSILFDYEYLNPNEEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFG
EPDRVGPQKFLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSAS
FISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGA
SPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQ
GERRNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQIYQ
RCWLVFKKASSKGPKRLEKFSDERAAYFRCYHKVTELNNVKNVARLPKSTKKHAIGIYFNDDTSKTFACESDLEADEWCKVLQMECVGTR
INDISLGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECALQITYEYICLWDVQNPRVKLISWPLSALRRYGRDTTWFTFEAGRMCETG
EGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYRLQDVSSPLKLHR

--------------------------------------------------------------
>58789_58789_2_NFATC2-DOK5_NFATC2_chr20_50133323_ENST00000609507_DOK5_chr20_53171472_ENST00000262593_length(transcript)=2507nt_BP=960nt
TCTGGAGTAAGCCGGATCGCGGAGCCGCGCCGACTCCGCCGAGCCGGGAGCCGGGAGGCGCGCAGCTCCCGGGTCGCTCCGAGGCTCCTC
GGCCAGGGCAGCCCCGCGGGCACGCGGTAGAGAAGACGGCGTCCCCTCGGCTGCTGGTCGATACAAACAGATCCCCCTTTCCAAACACGC
GCCAAGTCCCCGTGCCCTCCAGATGCAGAGAGAGGCTGCGTTCAGACTGGGGCACTGCCATCCCCTCCGCATCATGGGGTCTGTGGACCA
AGAACCTCGCCAATAATGTCACCTCGAACCAGCCTCGCCGAGGACAGCTGCCTGGGCCGCCACTCGCCCGTGCCCCGTCCGGCCTCCCGC
TCCTCATCGCCTGGTGCCAAGCGGAGGCATTCGTGCGCCGAGGCCTTGGTTGCCCTGCCGCCCGGAGCCTCACCCCAGCGCTCCCGGAGC
CCCTCGCCGCAGCCCTCATCTCACGTGGCACCCCAGGACCACGGCTCCCCGGCTGGGTACCCCCCTGTGGCTGGCTCTGCCGTGATCATG
GATGCCCTGAACAGCCTCGCCACGGACTCGCCTTGTGGGATCCCCCCCAAGATGTGGAAGACCAGCCCTGACCCCTCGCCGGTGTCTGCC
GCCCCATCCAAGGCCGGCCTGCCTCGCCACATCTACCCGGCCGTGGAGTTCCTGGGGCCCTGCGAGCAGGGCGAGAGGAGAAACTCGGCT
CCAGAATCCATCCTGCTGGTTCCGCCCACTTGGCCCAAGCCGCTGGTGCCTGCCATTCCCATCTGCAGCATCCCAGTGACTGCATCCCTC
CCTCCACTTGAGTGGCCGCTGTCCAGTCAGTCAGGCTCTTACGAGCTGCGGATCGAGGTGCAGCCCAAGCCACATCACCGGGCCCACTAT
GAGACAGAAGGCAGCCGAGGGGCTGTCAAAGCTCCAACTGGAGGCCACCCTGTGGTTCAGATTTATCAGCGATGCTGGTTAGTATTCAAG
AAAGCTTCAAGCAAAGGTCCAAAAAGACTGGAGAAATTTTCTGATGAACGTGCTGCATATTTCAGGTGTTATCATAAGGTTACAGAACTC
AATAATGTGAAGAACGTAGCTCGATTGCCAAAAAGCACCAAGAAACATGCCATAGGGATTTATTTCAATGACGATACCTCCAAGACTTTT
GCTTGCGAATCAGATCTTGAGGCTGATGAGTGGTGCAAAGTACTCCAGATGGAGTGTGTAGGAACACGGATCAATGACATCAGCCTTGGA
GAGCCTGACTTACTGGCCACTGGGGTTGAGAGAGAACAGAGTGAGAGATTCAATGTGTATTTGATGCCATCTCCTAACTTAGATGTACAT
GGCGAATGTGCCTTGCAGATTACATATGAGTATATCTGTCTTTGGGACGTCCAGAATCCCAGAGTCAAACTCATCTCTTGGCCGCTAAGC
GCCCTGCGGCGGTATGGACGTGATACTACGTGGTTCACTTTTGAGGCAGGGAGGATGTGTGAGACTGGTGAAGGGCTGTTTATCTTTCAG
ACCCGAGACGGGGAGGCCATCTATCAGAAAGTCCACTCTGCTGCCTTGGCCATAGCCGAGCAGCACGAGCGCTTGCTACAGAGTGTGAAA
AACTCGATGCTCCAGATGAAGATGAGTGAGCGGGCCGCCTCGCTGAGCACCATGGTGCCCCTGCCTCGCAGCGCCTACTGGCAGCACATC
ACACGGCAGCACAGCACGGGACAGCTCTACCGCTTGCAAGATGTTTCCAGCCCTCTGAAGCTTCATCGAACAGAGACTTTTCCAGCCTAC
AGATCTGAGCACTGACAGTAACTGCCAAGAATTGTTAACACACTTGTGATGTGTCAGCCACAGATTCACCCAGGAGGTCACAGAATGACA
GCAAGGGAAATGACGACCAAGAGAAGAAGCTTAAAGTCCTGGCTAATTGTGTGGTCATTGGAAAACTCTGCAATACAATAATTTTCTTTA
TTTTCTTTTTCTTTTTTAAATTCTTAGTGTAATTGAAACGTGCTCTATAGATATTGACTCTGTGTTCCCTCTTTTACAGCTGGACAGAAA
GAAGTCAATGTCACGAAATGATTTTCTATTGTAGATACTTTGTCCCTTGCACTTCTCTGAATCTGTCCTTTTGTGGATTCTTGTGATTTT
CCTTCCAAGTGTTTCAGTTGTATGACAGTCAGTATTGACAATAAAATGGCTTTTAATTATTTGTTATTTGTTTACACCCTATTCCTCAGT
TATTATTACTGTGGTTCTGATTAACTACTGGAAATTATATTTGATTATATCACCAATTAGTTAAATCAGTGCTTCGACTCACTCTTATCT
GTTCTGTTCAAAACTATTTGTTCAAAGAACCCGTTAGTGTTGTTTACAGGGTTACAGTTTCTCTCACATGCTTTCCTCACCCCTTTACCC

>58789_58789_2_NFATC2-DOK5_NFATC2_chr20_50133323_ENST00000609507_DOK5_chr20_53171472_ENST00000262593_length(amino acids)=526AA_BP=2
MPSPPHHGVCGPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGSPA
GYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLVPA
IPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQIYQRCWLVFKKASSKGPKRLEKFSDERA
AYFRCYHKVTELNNVKNVARLPKSTKKHAIGIYFNDDTSKTFACESDLEADEWCKVLQMECVGTRINDISLGEPDLLATGVEREQSERFN
VYLMPSPNLDVHGECALQITYEYICLWDVQNPRVKLISWPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAI

--------------------------------------------------------------
>58789_58789_3_NFATC2-DOK5_NFATC2_chr20_50133323_ENST00000609943_DOK5_chr20_53171472_ENST00000262593_length(transcript)=3021nt_BP=1474nt
TCTGGAGTAAGCCGGATCGCGGAGCCGCGCCGACTCCGCCGAGCCGGGAGCCGGGAGGCGCGCAGCTCCCGGGTCGCTCCGAGGCTCCTC
GGCCAGGGCAGCCCCGCGGGCACGCGGTAGAGAAGACGGCGTCCCCTCGGCTGCTGGTCGATACAAACAGATCCCCCTTTCCAAACACGC
GCCAAGTCCCCGTGCCCTCCAGATGCAGAGAGAGGCTGCGTTCAGACTGGGGCACTGCCATCCCCTCCGCATCATGGGGTCTGTGGACCA
AGAAGAGCCGAATGCACATAAGGTCGCCAGCCCACCCTCCGGACCCGCATACCCCGATGATGTCCTGGACTATGGCCTCAAGCCATACAG
CCCCCTTGCTAGTCTCTCTGGCGAGCCCCCCGGCCGATTCGGAGAGCCGGATAGGGTAGGGCCGCAGAAGTTTCTGAGCGCGGCCAAGCC
AGCAGGGGCCTCGGGCCTGAGCCCTCGGATCGAGATCACTCCGTCCCACGAACTGATCCAGGCAGTGGGGCCCCTCCGCATGAGAGACGC
GGGCCTCCTGGTGGAGCAGCCGCCCCTGGCCGGGGTGGCCGCCAGCCCGAGGTTCACCCTGCCCGTGCCCGGCTTCGAGGGCTACCGCGA
GCCGCTTTGCTTGAGCCCCGCTAGCAGCGGCTCCTCTGCCAGCTTCATTTCTGACACCTTCTCCCCCTACACCTCGCCCTGCGTCTCGCC
CAATAACGGCGGGCCCGACGACCTGTGTCCGCAGTTTCAAAACATCCCTGCTCATTATTCCCCCAGAACCTCGCCAATAATGTCACCTCG
AACCAGCCTCGCCGAGGACAGCTGCCTGGGCCGCCACTCGCCCGTGCCCCGTCCGGCCTCCCGCTCCTCATCGCCTGGTGCCAAGCGGAG
GCATTCGTGCGCCGAGGCCTTGGTTGCCCTGCCGCCCGGAGCCTCACCCCAGCGCTCCCGGAGCCCCTCGCCGCAGCCCTCATCTCACGT
GGCACCCCAGGACCACGGCTCCCCGGCTGGGTACCCCCCTGTGGCTGGCTCTGCCGTGATCATGGATGCCCTGAACAGCCTCGCCACGGA
CTCGCCTTGTGGGATCCCCCCCAAGATGTGGAAGACCAGCCCTGACCCCTCGCCGGTGTCTGCCGCCCCATCCAAGGCCGGCCTGCCTCG
CCACATCTACCCGGCCGTGGAGTTCCTGGGGCCCTGCGAGCAGGGCGAGAGGAGAAACTCGGCTCCAGAATCCATCCTGCTGGTTCCGCC
CACTTGGCCCAAGCCGCTGGTGCCTGCCATTCCCATCTGCAGCATCCCAGTGACTGCATCCCTCCCTCCACTTGAGTGGCCGCTGTCCAG
TCAGTCAGGCTCTTACGAGCTGCGGATCGAGGTGCAGCCCAAGCCACATCACCGGGCCCACTATGAGACAGAAGGCAGCCGAGGGGCTGT
CAAAGCTCCAACTGGAGGCCACCCTGTGGTTCAGATTTATCAGCGATGCTGGTTAGTATTCAAGAAAGCTTCAAGCAAAGGTCCAAAAAG
ACTGGAGAAATTTTCTGATGAACGTGCTGCATATTTCAGGTGTTATCATAAGGTTACAGAACTCAATAATGTGAAGAACGTAGCTCGATT
GCCAAAAAGCACCAAGAAACATGCCATAGGGATTTATTTCAATGACGATACCTCCAAGACTTTTGCTTGCGAATCAGATCTTGAGGCTGA
TGAGTGGTGCAAAGTACTCCAGATGGAGTGTGTAGGAACACGGATCAATGACATCAGCCTTGGAGAGCCTGACTTACTGGCCACTGGGGT
TGAGAGAGAACAGAGTGAGAGATTCAATGTGTATTTGATGCCATCTCCTAACTTAGATGTACATGGCGAATGTGCCTTGCAGATTACATA
TGAGTATATCTGTCTTTGGGACGTCCAGAATCCCAGAGTCAAACTCATCTCTTGGCCGCTAAGCGCCCTGCGGCGGTATGGACGTGATAC
TACGTGGTTCACTTTTGAGGCAGGGAGGATGTGTGAGACTGGTGAAGGGCTGTTTATCTTTCAGACCCGAGACGGGGAGGCCATCTATCA
GAAAGTCCACTCTGCTGCCTTGGCCATAGCCGAGCAGCACGAGCGCTTGCTACAGAGTGTGAAAAACTCGATGCTCCAGATGAAGATGAG
TGAGCGGGCCGCCTCGCTGAGCACCATGGTGCCCCTGCCTCGCAGCGCCTACTGGCAGCACATCACACGGCAGCACAGCACGGGACAGCT
CTACCGCTTGCAAGATGTTTCCAGCCCTCTGAAGCTTCATCGAACAGAGACTTTTCCAGCCTACAGATCTGAGCACTGACAGTAACTGCC
AAGAATTGTTAACACACTTGTGATGTGTCAGCCACAGATTCACCCAGGAGGTCACAGAATGACAGCAAGGGAAATGACGACCAAGAGAAG
AAGCTTAAAGTCCTGGCTAATTGTGTGGTCATTGGAAAACTCTGCAATACAATAATTTTCTTTATTTTCTTTTTCTTTTTTAAATTCTTA
GTGTAATTGAAACGTGCTCTATAGATATTGACTCTGTGTTCCCTCTTTTACAGCTGGACAGAAAGAAGTCAATGTCACGAAATGATTTTC
TATTGTAGATACTTTGTCCCTTGCACTTCTCTGAATCTGTCCTTTTGTGGATTCTTGTGATTTTCCTTCCAAGTGTTTCAGTTGTATGAC
AGTCAGTATTGACAATAAAATGGCTTTTAATTATTTGTTATTTGTTTACACCCTATTCCTCAGTTATTATTACTGTGGTTCTGATTAACT
ACTGGAAATTATATTTGATTATATCACCAATTAGTTAAATCAGTGCTTCGACTCACTCTTATCTGTTCTGTTCAAAACTATTTGTTCAAA
GAACCCGTTAGTGTTGTTTACAGGGTTACAGTTTCTCTCACATGCTTTCCTCACCCCTTTACCCCCCTTTTTGAAAGCCTTTATTTTGTT

>58789_58789_3_NFATC2-DOK5_NFATC2_chr20_50133323_ENST00000609943_DOK5_chr20_53171472_ENST00000262593_length(amino acids)=708AA_BP=423
MQREAAFRLGHCHPLRIMGSVDQEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKFLSAAKPAGASGLS
PRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDD
LCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGS
PAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLV
PAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQIYQRCWLVFKKASSKGPKRLEKFSDE
RAAYFRCYHKVTELNNVKNVARLPKSTKKHAIGIYFNDDTSKTFACESDLEADEWCKVLQMECVGTRINDISLGEPDLLATGVEREQSER
FNVYLMPSPNLDVHGECALQITYEYICLWDVQNPRVKLISWPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAAL

--------------------------------------------------------------
>58789_58789_4_NFATC2-DOK5_NFATC2_chr20_50133323_ENST00000610033_DOK5_chr20_53171472_ENST00000262593_length(transcript)=2585nt_BP=1038nt
AGCAGGAAGCTCGCGCCGCCGTCGCCGCCGCCGCTCAGCTTCCCCGGGCGCGTCCAGGACCCGCTGCGCCAGGCGCGCCGTCCCCGGACC
CGGCGTGCGTCCCTACGAGGAAAGGGACCCCGCCGCTCGAGCCGCCTCCGCCAGCCCCACTGCGAGGGGTCCCAGAGCCAGCCGCGCCCG
CCCTCGCCCCCGGCCCCGCAGCCTTCCCGCCCTGCGCGCCATGAACGCCCCCGAGCGGCAGCCCCAACCCGACGGCGGGGACGCCCCAGG
CCACGAGCCTGGGGGCAGCCCCCAAGACGAGCTTGACTTCTCCATCCTCTTCGACTATGAGTATTTGAATCCGAACGAAGAACCTCGCCA
ATAATGTCACCTCGAACCAGCCTCGCCGAGGACAGCTGCCTGGGCCGCCACTCGCCCGTGCCCCGTCCGGCCTCCCGCTCCTCATCGCCT
GGTGCCAAGCGGAGGCATTCGTGCGCCGAGGCCTTGGTTGCCCTGCCGCCCGGAGCCTCACCCCAGCGCTCCCGGAGCCCCTCGCCGCAG
CCCTCATCTCACGTGGCACCCCAGGACCACGGCTCCCCGGCTGGGTACCCCCCTGTGGCTGGCTCTGCCGTGATCATGGATGCCCTGAAC
AGCCTCGCCACGGACTCGCCTTGTGGGATCCCCCCCAAGATGTGGAAGACCAGCCCTGACCCCTCGCCGGTGTCTGCCGCCCCATCCAAG
GCCGGCCTGCCTCGCCACATCTACCCGGCCGTGGAGTTCCTGGGGCCCTGCGAGCAGGGCGAGAGGAGAAACTCGGCTCCAGAATCCATC
CTGCTGGTTCCGCCCACTTGGCCCAAGCCGCTGGTGCCTGCCATTCCCATCTGCAGCATCCCAGTGACTGCATCCCTCCCTCCACTTGAG
TGGCCGCTGTCCAGTCAGTCAGGCTCTTACGAGCTGCGGATCGAGGTGCAGCCCAAGCCACATCACCGGGCCCACTATGAGACAGAAGGC
AGCCGAGGGGCTGTCAAAGCTCCAACTGGAGGCCACCCTGTGGTTCAGATTTATCAGCGATGCTGGTTAGTATTCAAGAAAGCTTCAAGC
AAAGGTCCAAAAAGACTGGAGAAATTTTCTGATGAACGTGCTGCATATTTCAGGTGTTATCATAAGGTTACAGAACTCAATAATGTGAAG
AACGTAGCTCGATTGCCAAAAAGCACCAAGAAACATGCCATAGGGATTTATTTCAATGACGATACCTCCAAGACTTTTGCTTGCGAATCA
GATCTTGAGGCTGATGAGTGGTGCAAAGTACTCCAGATGGAGTGTGTAGGAACACGGATCAATGACATCAGCCTTGGAGAGCCTGACTTA
CTGGCCACTGGGGTTGAGAGAGAACAGAGTGAGAGATTCAATGTGTATTTGATGCCATCTCCTAACTTAGATGTACATGGCGAATGTGCC
TTGCAGATTACATATGAGTATATCTGTCTTTGGGACGTCCAGAATCCCAGAGTCAAACTCATCTCTTGGCCGCTAAGCGCCCTGCGGCGG
TATGGACGTGATACTACGTGGTTCACTTTTGAGGCAGGGAGGATGTGTGAGACTGGTGAAGGGCTGTTTATCTTTCAGACCCGAGACGGG
GAGGCCATCTATCAGAAAGTCCACTCTGCTGCCTTGGCCATAGCCGAGCAGCACGAGCGCTTGCTACAGAGTGTGAAAAACTCGATGCTC
CAGATGAAGATGAGTGAGCGGGCCGCCTCGCTGAGCACCATGGTGCCCCTGCCTCGCAGCGCCTACTGGCAGCACATCACACGGCAGCAC
AGCACGGGACAGCTCTACCGCTTGCAAGATGTTTCCAGCCCTCTGAAGCTTCATCGAACAGAGACTTTTCCAGCCTACAGATCTGAGCAC
TGACAGTAACTGCCAAGAATTGTTAACACACTTGTGATGTGTCAGCCACAGATTCACCCAGGAGGTCACAGAATGACAGCAAGGGAAATG
ACGACCAAGAGAAGAAGCTTAAAGTCCTGGCTAATTGTGTGGTCATTGGAAAACTCTGCAATACAATAATTTTCTTTATTTTCTTTTTCT
TTTTTAAATTCTTAGTGTAATTGAAACGTGCTCTATAGATATTGACTCTGTGTTCCCTCTTTTACAGCTGGACAGAAAGAAGTCAATGTC
ACGAAATGATTTTCTATTGTAGATACTTTGTCCCTTGCACTTCTCTGAATCTGTCCTTTTGTGGATTCTTGTGATTTTCCTTCCAAGTGT
TTCAGTTGTATGACAGTCAGTATTGACAATAAAATGGCTTTTAATTATTTGTTATTTGTTTACACCCTATTCCTCAGTTATTATTACTGT
GGTTCTGATTAACTACTGGAAATTATATTTGATTATATCACCAATTAGTTAAATCAGTGCTTCGACTCACTCTTATCTGTTCTGTTCAAA
ACTATTTGTTCAAAGAACCCGTTAGTGTTGTTTACAGGGTTACAGTTTCTCTCACATGCTTTCCTCACCCCTTTACCCCCCTTTTTGAAA

>58789_58789_4_NFATC2-DOK5_NFATC2_chr20_50133323_ENST00000610033_DOK5_chr20_53171472_ENST00000262593_length(amino acids)=509AA_BP=224
MSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNS
LATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEW
PLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQIYQRCWLVFKKASSKGPKRLEKFSDERAAYFRCYHKVTELNNVKN
VARLPKSTKKHAIGIYFNDDTSKTFACESDLEADEWCKVLQMECVGTRINDISLGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECAL
QITYEYICLWDVQNPRVKLISWPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NFATC2-DOK5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NFATC2-DOK5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NFATC2-DOK5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNFATC2C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneNFATC2C0020542Pulmonary Hypertension1CTD_human
HgeneNFATC2C0027765nervous system disorder1CTD_human
TgeneC0005586Bipolar Disorder1PSYGENET