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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:LAP3-DDX1 (FusionGDB2 ID:HG51056TG1653) |
Fusion Gene Summary for LAP3-DDX1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LAP3-DDX1 | Fusion gene ID: hg51056tg1653 | Hgene | Tgene | Gene symbol | LAP3 | DDX1 | Gene ID | 51056 | 1653 |
| Gene name | leucine aminopeptidase 3 | DEAD-box helicase 1 | |
| Synonyms | HEL-S-106|LAP|LAPEP|PEPS | DBP-RB|UKVH5d | |
| Cytomap | ('LAP3')('DDX1') 4p15.32 | 2p24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytosol aminopeptidaseLAP-3epididymis secretory protein Li 106leucyl aminopeptidasepeptidase Sproline aminopeptidaseprolyl aminopeptidase | ATP-dependent RNA helicase DDX1DEAD (Asp-Glu-Ala-Asp) box helicase 1DEAD (Asp-Glu-Ala-Asp) box polypeptide 1DEAD box polypeptide 1DEAD box protein 1DEAD box protein retinoblastomaDEAD box-1DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1DEAD/H-box h | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q92499 | |
| Ensembl transtripts involved in fusion gene | ENST00000226299, ENST00000606142, ENST00000503467, | ||
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 4 X 5 X 3=60 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LAP3 [Title/Abstract] AND DDX1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | LAP3(17583437)-DDX1(15746274), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | LAP3-DDX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LAP3-DDX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LAP3-DDX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LAP3-DDX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DDX1 | GO:0006302 | double-strand break repair | 18710941 |
| Tgene | DDX1 | GO:0032508 | DNA duplex unwinding | 18710941 |
| Tgene | DDX1 | GO:0090305 | nucleic acid phosphodiester bond hydrolysis | 18710941 |
| Fusion gene breakpoints across LAP3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across DDX1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BLCA | TCGA-G2-A2EF-01A | LAP3 | chr4 | 17583437 | - | DDX1 | chr2 | 15746274 | + |
| ChimerDB4 | BLCA | TCGA-G2-A2EF-01A | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746274 | + |
| ChimerDB4 | BLCA | TCGA-G2-A2EF | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746273 | + |
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Fusion Gene ORF analysis for LAP3-DDX1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000226299 | ENST00000233084 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746274 | + |
| In-frame | ENST00000226299 | ENST00000233084 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746273 | + |
| In-frame | ENST00000226299 | ENST00000381341 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746274 | + |
| In-frame | ENST00000226299 | ENST00000381341 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746273 | + |
| In-frame | ENST00000606142 | ENST00000233084 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746274 | + |
| In-frame | ENST00000606142 | ENST00000233084 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746273 | + |
| In-frame | ENST00000606142 | ENST00000381341 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746274 | + |
| In-frame | ENST00000606142 | ENST00000381341 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746273 | + |
| intron-3CDS | ENST00000503467 | ENST00000233084 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746274 | + |
| intron-3CDS | ENST00000503467 | ENST00000233084 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746273 | + |
| intron-3CDS | ENST00000503467 | ENST00000381341 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746274 | + |
| intron-3CDS | ENST00000503467 | ENST00000381341 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746273 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000226299 | LAP3 | chr4 | 17583437 | + | ENST00000381341 | DDX1 | chr2 | 15746274 | + | 2273 | 547 | 184 | 2067 | 627 |
| ENST00000226299 | LAP3 | chr4 | 17583437 | + | ENST00000233084 | DDX1 | chr2 | 15746274 | + | 2263 | 547 | 184 | 2067 | 627 |
| ENST00000606142 | LAP3 | chr4 | 17583437 | + | ENST00000381341 | DDX1 | chr2 | 15746274 | + | 1970 | 244 | 19 | 1764 | 581 |
| ENST00000606142 | LAP3 | chr4 | 17583437 | + | ENST00000233084 | DDX1 | chr2 | 15746274 | + | 1960 | 244 | 19 | 1764 | 581 |
| ENST00000226299 | LAP3 | chr4 | 17583437 | + | ENST00000381341 | DDX1 | chr2 | 15746273 | + | 2273 | 547 | 184 | 2067 | 627 |
| ENST00000226299 | LAP3 | chr4 | 17583437 | + | ENST00000233084 | DDX1 | chr2 | 15746273 | + | 2263 | 547 | 184 | 2067 | 627 |
| ENST00000606142 | LAP3 | chr4 | 17583437 | + | ENST00000381341 | DDX1 | chr2 | 15746273 | + | 1970 | 244 | 19 | 1764 | 581 |
| ENST00000606142 | LAP3 | chr4 | 17583437 | + | ENST00000233084 | DDX1 | chr2 | 15746273 | + | 1960 | 244 | 19 | 1764 | 581 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000226299 | ENST00000381341 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746274 | + | 0.000629676 | 0.9993704 |
| ENST00000226299 | ENST00000233084 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746274 | + | 0.000610711 | 0.9993893 |
| ENST00000606142 | ENST00000381341 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746274 | + | 0.000636292 | 0.9993637 |
| ENST00000606142 | ENST00000233084 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746274 | + | 0.000620971 | 0.99937904 |
| ENST00000226299 | ENST00000381341 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746273 | + | 0.000629676 | 0.9993704 |
| ENST00000226299 | ENST00000233084 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746273 | + | 0.000610711 | 0.9993893 |
| ENST00000606142 | ENST00000381341 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746273 | + | 0.000636292 | 0.9993637 |
| ENST00000606142 | ENST00000233084 | LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746273 | + | 0.000620971 | 0.99937904 |
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Fusion Genomic Features for LAP3-DDX1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746273 | + | 0.001819627 | 0.9981804 |
| LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746273 | + | 0.001819627 | 0.9981804 |
| LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746273 | + | 0.001819627 | 0.9981804 |
| LAP3 | chr4 | 17583437 | + | DDX1 | chr2 | 15746273 | + | 0.001819627 | 0.9981804 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for LAP3-DDX1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:17583437/chr2:15746274) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | DDX1 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (PubMed:24870230). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity). {ECO:0000250|UniProtKB:Q91VR5, ECO:0000269|PubMed:12183465, ECO:0000269|PubMed:15567440, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:18710941, ECO:0000269|PubMed:20573827, ECO:0000269|PubMed:24870230}.; FUNCTION: (Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. Binds to the RRE sequence of HIV-1 mRNAs. {ECO:0000269|PubMed:15567440}.; FUNCTION: (Microbial infection) Required for Coronavirus IBV replication. {ECO:0000269|PubMed:20573827}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | DDX1 | chr4:17583437 | chr2:15746273 | ENST00000233084 | 10 | 26 | 493_681 | 234 | 741.0 | Domain | Helicase C-terminal | |
| Tgene | DDX1 | chr4:17583437 | chr2:15746273 | ENST00000381341 | 11 | 27 | 493_681 | 234 | 741.0 | Domain | Helicase C-terminal | |
| Tgene | DDX1 | chr4:17583437 | chr2:15746274 | ENST00000233084 | 10 | 26 | 493_681 | 234 | 741.0 | Domain | Helicase C-terminal | |
| Tgene | DDX1 | chr4:17583437 | chr2:15746274 | ENST00000381341 | 11 | 27 | 493_681 | 234 | 741.0 | Domain | Helicase C-terminal | |
| Tgene | DDX1 | chr4:17583437 | chr2:15746273 | ENST00000233084 | 10 | 26 | 370_373 | 234 | 741.0 | Motif | DEAD box | |
| Tgene | DDX1 | chr4:17583437 | chr2:15746273 | ENST00000381341 | 11 | 27 | 370_373 | 234 | 741.0 | Motif | DEAD box | |
| Tgene | DDX1 | chr4:17583437 | chr2:15746274 | ENST00000233084 | 10 | 26 | 370_373 | 234 | 741.0 | Motif | DEAD box | |
| Tgene | DDX1 | chr4:17583437 | chr2:15746274 | ENST00000381341 | 11 | 27 | 370_373 | 234 | 741.0 | Motif | DEAD box |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | DDX1 | chr4:17583437 | chr2:15746273 | ENST00000233084 | 10 | 26 | 2_428 | 234 | 741.0 | Domain | Helicase ATP-binding | |
| Tgene | DDX1 | chr4:17583437 | chr2:15746273 | ENST00000233084 | 10 | 26 | 70_247 | 234 | 741.0 | Domain | B30.2/SPRY | |
| Tgene | DDX1 | chr4:17583437 | chr2:15746273 | ENST00000381341 | 11 | 27 | 2_428 | 234 | 741.0 | Domain | Helicase ATP-binding | |
| Tgene | DDX1 | chr4:17583437 | chr2:15746273 | ENST00000381341 | 11 | 27 | 70_247 | 234 | 741.0 | Domain | B30.2/SPRY | |
| Tgene | DDX1 | chr4:17583437 | chr2:15746274 | ENST00000233084 | 10 | 26 | 2_428 | 234 | 741.0 | Domain | Helicase ATP-binding | |
| Tgene | DDX1 | chr4:17583437 | chr2:15746274 | ENST00000233084 | 10 | 26 | 70_247 | 234 | 741.0 | Domain | B30.2/SPRY | |
| Tgene | DDX1 | chr4:17583437 | chr2:15746274 | ENST00000381341 | 11 | 27 | 2_428 | 234 | 741.0 | Domain | Helicase ATP-binding | |
| Tgene | DDX1 | chr4:17583437 | chr2:15746274 | ENST00000381341 | 11 | 27 | 70_247 | 234 | 741.0 | Domain | B30.2/SPRY | |
| Tgene | DDX1 | chr4:17583437 | chr2:15746273 | ENST00000233084 | 10 | 26 | 46_53 | 234 | 741.0 | Nucleotide binding | ATP | |
| Tgene | DDX1 | chr4:17583437 | chr2:15746273 | ENST00000381341 | 11 | 27 | 46_53 | 234 | 741.0 | Nucleotide binding | ATP | |
| Tgene | DDX1 | chr4:17583437 | chr2:15746274 | ENST00000233084 | 10 | 26 | 46_53 | 234 | 741.0 | Nucleotide binding | ATP | |
| Tgene | DDX1 | chr4:17583437 | chr2:15746274 | ENST00000381341 | 11 | 27 | 46_53 | 234 | 741.0 | Nucleotide binding | ATP |
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Fusion Gene Sequence for LAP3-DDX1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >44034_44034_1_LAP3-DDX1_LAP3_chr4_17583437_ENST00000226299_DDX1_chr2_15746273_ENST00000233084_length(transcript)=2263nt_BP=547nt GCGGGCGCACACGAATGCGGGCGCACACGAATGCGGGCGCACACGAATGCGGGCGCACCCTTGAGTCCCCTCCACAACCGCGGTTTGATC CCAGCGGTCCAGTCGGCCGGTGCTGCCCATCCGTCCCGCCCCCTAGACGCACGTCCGCTCGCCCGGCGCCCGAGCCAGTCCGCGCGCACG CCGTCTGCGCCCCGAAAGCCCCGCCCCAAGGCGCGCCCGCCCACCGCTCTCCACGTGCTCGCTGGAGGGCGGTGCGAGGGGCCGAGCCGA CAAGATGTTCTTGCTGCCTCTTCCGGCTGCGGGGCGAGTAGTCGTCCGACGTCTGGCCGTGAGACGTTTCGGGAGCCGGAGTCTCTCCAC CGCAGACATGACGAAGGGCCTTGTTTTAGGAATCTATTCCAAAGAAAAAGAAGATGATGTGCCACAGTTCACAAGTGCAGGAGAGAATTT TGATAAATTGTTAGCTGGAAAGCTGAGAGAGACTTTGAACATATCTGGACCACCTCTGAAGGCAGGGAAGACTCGAACCTTTTATGGTCT GCATCAGAATGCTGAACTGAAATTTAACTTCGGTGAAGAGGAATTTAAGTTTCCACCAAAAGATGGCTTTGTTGCTCTTTCCAAGGCACC GGATGGTTACATTGTCAAATCACAGCACTCAGGTAATGCACAGGTGACACAAACAAAGTTTCTCCCCAATGCTCCGAAAGCTCTCATTGT TGAACCTTCCCGGGAGTTAGCTGAACAAACTTTGAACAACATCAAGCAGTTTAAGAAATACATTGATAATCCTAAATTAAGGGAGCTTCT GATAATTGGAGGTGTTGCAGCCCGGGATCAGCTCTCTGTTTTGGAAAATGGAGTAGATATAGTTGTAGGTACTCCGGGAAGACTAGATGA CTTGGTGTCAACTGGAAAGCTGAACTTATCTCAAGTTAGATTCCTGGTCCTGGATGAAGCTGATGGGCTTCTTTCTCAAGGTTATTCTGA TTTTATAAATAGGATGCACAATCAGATTCCTCAGGTTACCTCTGATGGAAAAAGACTTCAGGTGATTGTTTGCTCTGCCACTTTGCATTC TTTCGATGTAAAGAAACTGTCCGAGAAGATAATGCATTTTCCTACATGGGTTGACTTAAAAGGAGAAGACTCTGTTCCAGATACTGTACA CCATGTTGTTGTCCCAGTAAATCCCAAAACTGACAGACTCTGGGAAAGGCTTGGAAAGAGCCACATTAGAACTGATGATGTACATGCAAA AGATAACACAAGACCTGGTGCTAATAGTCCAGAGATGTGGTCTGAAGCTATTAAAATCCTGAAAGGGGAGTATGCTGTCCGGGCAATCAA GGAACATAAGATGGATCAAGCAATTATCTTCTGTAGAACCAAAATTGACTGTGATAACTTGGAGCAGTACTTTATACAACAAGGAGGAGG ACCTGATAAAAAAGGACACCAGTTCTCATGTGTTTGTCTTCATGGTGACAGAAAGCCTCATGAGAGAAAGCAAAACTTGGAAAGATTTAA GAAAGGAGATGTAAGATTCTTGATTTGCACAGATGTAGCTGCTAGAGGAATTGATATCCACGGTGTTCCTTATGTTATAAATGTCACTCT GCCCGATGAAAAGCAAAACTACGTACATCGAATTGGCAGAGTAGGAAGAGCTGAAAGGATGGGTCTGGCAATTTCCCTGGTGGCAACAGA AAAAGAAAAGGTTTGGTACCATGTATGTAGCAGCCGTGGAAAAGGGTGTTATAACACAAGACTCAAGGAAGATGGAGGCTGTACCATATG GTACAACGAGATGCAGTTACTATCTGAGATAGAAGAACACCTGAACTGTACCATTTCTCAGGTTGAGCCGGATATAAAGGTACCAGTGGA TGAATTTGATGGGAAAGTTACCTACGGTCAGAAAAGGGCTGCTGGTGGTGGAAGCTATAAAGGCCATGTGGATATTTTGGCACCTACTGT TCAAGAGTTGGCTGCCCTTGAAAAGGAGGCGCAGACATCTTTCCTGCATCTTGGCTACCTTCCTAACCAGCTGTTCAGAACCTTCTGATT TTTACATTTACTGAATAAGATTTGAGTAATGAAAGTCTGTAGTCTTAAAACTCTAAAACAGTTGTACTGCTTCCAAGCAGCAGTATTTAT AGTAACGTAAGCTATTAATGCTAACTCTTGCATGTCAAGAAACATTAGTCTTAGGAATTCTTCAAAAAATGGCATCCCAATGAAAATAAA >44034_44034_1_LAP3-DDX1_LAP3_chr4_17583437_ENST00000226299_DDX1_chr2_15746273_ENST00000233084_length(amino acids)=627AA_BP=121 MRPESPAPRRARPPLSTCSLEGGARGRADKMFLLPLPAAGRVVVRRLAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFD KLLAGKLRETLNISGPPLKAGKTRTFYGLHQNAELKFNFGEEEFKFPPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVE PSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDF INRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKD NTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKK GDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWY -------------------------------------------------------------- >44034_44034_2_LAP3-DDX1_LAP3_chr4_17583437_ENST00000226299_DDX1_chr2_15746273_ENST00000381341_length(transcript)=2273nt_BP=547nt GCGGGCGCACACGAATGCGGGCGCACACGAATGCGGGCGCACACGAATGCGGGCGCACCCTTGAGTCCCCTCCACAACCGCGGTTTGATC CCAGCGGTCCAGTCGGCCGGTGCTGCCCATCCGTCCCGCCCCCTAGACGCACGTCCGCTCGCCCGGCGCCCGAGCCAGTCCGCGCGCACG CCGTCTGCGCCCCGAAAGCCCCGCCCCAAGGCGCGCCCGCCCACCGCTCTCCACGTGCTCGCTGGAGGGCGGTGCGAGGGGCCGAGCCGA CAAGATGTTCTTGCTGCCTCTTCCGGCTGCGGGGCGAGTAGTCGTCCGACGTCTGGCCGTGAGACGTTTCGGGAGCCGGAGTCTCTCCAC CGCAGACATGACGAAGGGCCTTGTTTTAGGAATCTATTCCAAAGAAAAAGAAGATGATGTGCCACAGTTCACAAGTGCAGGAGAGAATTT TGATAAATTGTTAGCTGGAAAGCTGAGAGAGACTTTGAACATATCTGGACCACCTCTGAAGGCAGGGAAGACTCGAACCTTTTATGGTCT GCATCAGAATGCTGAACTGAAATTTAACTTCGGTGAAGAGGAATTTAAGTTTCCACCAAAAGATGGCTTTGTTGCTCTTTCCAAGGCACC GGATGGTTACATTGTCAAATCACAGCACTCAGGTAATGCACAGGTGACACAAACAAAGTTTCTCCCCAATGCTCCGAAAGCTCTCATTGT TGAACCTTCCCGGGAGTTAGCTGAACAAACTTTGAACAACATCAAGCAGTTTAAGAAATACATTGATAATCCTAAATTAAGGGAGCTTCT GATAATTGGAGGTGTTGCAGCCCGGGATCAGCTCTCTGTTTTGGAAAATGGAGTAGATATAGTTGTAGGTACTCCGGGAAGACTAGATGA CTTGGTGTCAACTGGAAAGCTGAACTTATCTCAAGTTAGATTCCTGGTCCTGGATGAAGCTGATGGGCTTCTTTCTCAAGGTTATTCTGA TTTTATAAATAGGATGCACAATCAGATTCCTCAGGTTACCTCTGATGGAAAAAGACTTCAGGTGATTGTTTGCTCTGCCACTTTGCATTC TTTCGATGTAAAGAAACTGTCCGAGAAGATAATGCATTTTCCTACATGGGTTGACTTAAAAGGAGAAGACTCTGTTCCAGATACTGTACA CCATGTTGTTGTCCCAGTAAATCCCAAAACTGACAGACTCTGGGAAAGGCTTGGAAAGAGCCACATTAGAACTGATGATGTACATGCAAA AGATAACACAAGACCTGGTGCTAATAGTCCAGAGATGTGGTCTGAAGCTATTAAAATCCTGAAAGGGGAGTATGCTGTCCGGGCAATCAA GGAACATAAGATGGATCAAGCAATTATCTTCTGTAGAACCAAAATTGACTGTGATAACTTGGAGCAGTACTTTATACAACAAGGAGGAGG ACCTGATAAAAAAGGACACCAGTTCTCATGTGTTTGTCTTCATGGTGACAGAAAGCCTCATGAGAGAAAGCAAAACTTGGAAAGATTTAA GAAAGGAGATGTAAGATTCTTGATTTGCACAGATGTAGCTGCTAGAGGAATTGATATCCACGGTGTTCCTTATGTTATAAATGTCACTCT GCCCGATGAAAAGCAAAACTACGTACATCGAATTGGCAGAGTAGGAAGAGCTGAAAGGATGGGTCTGGCAATTTCCCTGGTGGCAACAGA AAAAGAAAAGGTTTGGTACCATGTATGTAGCAGCCGTGGAAAAGGGTGTTATAACACAAGACTCAAGGAAGATGGAGGCTGTACCATATG GTACAACGAGATGCAGTTACTATCTGAGATAGAAGAACACCTGAACTGTACCATTTCTCAGGTTGAGCCGGATATAAAGGTACCAGTGGA TGAATTTGATGGGAAAGTTACCTACGGTCAGAAAAGGGCTGCTGGTGGTGGAAGCTATAAAGGCCATGTGGATATTTTGGCACCTACTGT TCAAGAGTTGGCTGCCCTTGAAAAGGAGGCGCAGACATCTTTCCTGCATCTTGGCTACCTTCCTAACCAGCTGTTCAGAACCTTCTGATT TTTACATTTACTGAATAAGATTTGAGTAATGAAAGTCTGTAGTCTTAAAACTCTAAAACAGTTGTACTGCTTCCAAGCAGCAGTATTTAT AGTAACGTAAGCTATTAATGCTAACTCTTGCATGTCAAGAAACATTAGTCTTAGGAATTCTTCAAAAAATGGCATCCCAATGAAAATAAA >44034_44034_2_LAP3-DDX1_LAP3_chr4_17583437_ENST00000226299_DDX1_chr2_15746273_ENST00000381341_length(amino acids)=627AA_BP=121 MRPESPAPRRARPPLSTCSLEGGARGRADKMFLLPLPAAGRVVVRRLAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFD KLLAGKLRETLNISGPPLKAGKTRTFYGLHQNAELKFNFGEEEFKFPPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVE PSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDF INRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKD NTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKK GDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWY -------------------------------------------------------------- >44034_44034_3_LAP3-DDX1_LAP3_chr4_17583437_ENST00000226299_DDX1_chr2_15746274_ENST00000233084_length(transcript)=2263nt_BP=547nt GCGGGCGCACACGAATGCGGGCGCACACGAATGCGGGCGCACACGAATGCGGGCGCACCCTTGAGTCCCCTCCACAACCGCGGTTTGATC CCAGCGGTCCAGTCGGCCGGTGCTGCCCATCCGTCCCGCCCCCTAGACGCACGTCCGCTCGCCCGGCGCCCGAGCCAGTCCGCGCGCACG CCGTCTGCGCCCCGAAAGCCCCGCCCCAAGGCGCGCCCGCCCACCGCTCTCCACGTGCTCGCTGGAGGGCGGTGCGAGGGGCCGAGCCGA CAAGATGTTCTTGCTGCCTCTTCCGGCTGCGGGGCGAGTAGTCGTCCGACGTCTGGCCGTGAGACGTTTCGGGAGCCGGAGTCTCTCCAC CGCAGACATGACGAAGGGCCTTGTTTTAGGAATCTATTCCAAAGAAAAAGAAGATGATGTGCCACAGTTCACAAGTGCAGGAGAGAATTT TGATAAATTGTTAGCTGGAAAGCTGAGAGAGACTTTGAACATATCTGGACCACCTCTGAAGGCAGGGAAGACTCGAACCTTTTATGGTCT GCATCAGAATGCTGAACTGAAATTTAACTTCGGTGAAGAGGAATTTAAGTTTCCACCAAAAGATGGCTTTGTTGCTCTTTCCAAGGCACC GGATGGTTACATTGTCAAATCACAGCACTCAGGTAATGCACAGGTGACACAAACAAAGTTTCTCCCCAATGCTCCGAAAGCTCTCATTGT TGAACCTTCCCGGGAGTTAGCTGAACAAACTTTGAACAACATCAAGCAGTTTAAGAAATACATTGATAATCCTAAATTAAGGGAGCTTCT GATAATTGGAGGTGTTGCAGCCCGGGATCAGCTCTCTGTTTTGGAAAATGGAGTAGATATAGTTGTAGGTACTCCGGGAAGACTAGATGA CTTGGTGTCAACTGGAAAGCTGAACTTATCTCAAGTTAGATTCCTGGTCCTGGATGAAGCTGATGGGCTTCTTTCTCAAGGTTATTCTGA TTTTATAAATAGGATGCACAATCAGATTCCTCAGGTTACCTCTGATGGAAAAAGACTTCAGGTGATTGTTTGCTCTGCCACTTTGCATTC TTTCGATGTAAAGAAACTGTCCGAGAAGATAATGCATTTTCCTACATGGGTTGACTTAAAAGGAGAAGACTCTGTTCCAGATACTGTACA CCATGTTGTTGTCCCAGTAAATCCCAAAACTGACAGACTCTGGGAAAGGCTTGGAAAGAGCCACATTAGAACTGATGATGTACATGCAAA AGATAACACAAGACCTGGTGCTAATAGTCCAGAGATGTGGTCTGAAGCTATTAAAATCCTGAAAGGGGAGTATGCTGTCCGGGCAATCAA GGAACATAAGATGGATCAAGCAATTATCTTCTGTAGAACCAAAATTGACTGTGATAACTTGGAGCAGTACTTTATACAACAAGGAGGAGG ACCTGATAAAAAAGGACACCAGTTCTCATGTGTTTGTCTTCATGGTGACAGAAAGCCTCATGAGAGAAAGCAAAACTTGGAAAGATTTAA GAAAGGAGATGTAAGATTCTTGATTTGCACAGATGTAGCTGCTAGAGGAATTGATATCCACGGTGTTCCTTATGTTATAAATGTCACTCT GCCCGATGAAAAGCAAAACTACGTACATCGAATTGGCAGAGTAGGAAGAGCTGAAAGGATGGGTCTGGCAATTTCCCTGGTGGCAACAGA AAAAGAAAAGGTTTGGTACCATGTATGTAGCAGCCGTGGAAAAGGGTGTTATAACACAAGACTCAAGGAAGATGGAGGCTGTACCATATG GTACAACGAGATGCAGTTACTATCTGAGATAGAAGAACACCTGAACTGTACCATTTCTCAGGTTGAGCCGGATATAAAGGTACCAGTGGA TGAATTTGATGGGAAAGTTACCTACGGTCAGAAAAGGGCTGCTGGTGGTGGAAGCTATAAAGGCCATGTGGATATTTTGGCACCTACTGT TCAAGAGTTGGCTGCCCTTGAAAAGGAGGCGCAGACATCTTTCCTGCATCTTGGCTACCTTCCTAACCAGCTGTTCAGAACCTTCTGATT TTTACATTTACTGAATAAGATTTGAGTAATGAAAGTCTGTAGTCTTAAAACTCTAAAACAGTTGTACTGCTTCCAAGCAGCAGTATTTAT AGTAACGTAAGCTATTAATGCTAACTCTTGCATGTCAAGAAACATTAGTCTTAGGAATTCTTCAAAAAATGGCATCCCAATGAAAATAAA >44034_44034_3_LAP3-DDX1_LAP3_chr4_17583437_ENST00000226299_DDX1_chr2_15746274_ENST00000233084_length(amino acids)=627AA_BP=121 MRPESPAPRRARPPLSTCSLEGGARGRADKMFLLPLPAAGRVVVRRLAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFD KLLAGKLRETLNISGPPLKAGKTRTFYGLHQNAELKFNFGEEEFKFPPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVE PSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDF INRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKD NTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKK GDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWY -------------------------------------------------------------- >44034_44034_4_LAP3-DDX1_LAP3_chr4_17583437_ENST00000226299_DDX1_chr2_15746274_ENST00000381341_length(transcript)=2273nt_BP=547nt GCGGGCGCACACGAATGCGGGCGCACACGAATGCGGGCGCACACGAATGCGGGCGCACCCTTGAGTCCCCTCCACAACCGCGGTTTGATC CCAGCGGTCCAGTCGGCCGGTGCTGCCCATCCGTCCCGCCCCCTAGACGCACGTCCGCTCGCCCGGCGCCCGAGCCAGTCCGCGCGCACG CCGTCTGCGCCCCGAAAGCCCCGCCCCAAGGCGCGCCCGCCCACCGCTCTCCACGTGCTCGCTGGAGGGCGGTGCGAGGGGCCGAGCCGA CAAGATGTTCTTGCTGCCTCTTCCGGCTGCGGGGCGAGTAGTCGTCCGACGTCTGGCCGTGAGACGTTTCGGGAGCCGGAGTCTCTCCAC CGCAGACATGACGAAGGGCCTTGTTTTAGGAATCTATTCCAAAGAAAAAGAAGATGATGTGCCACAGTTCACAAGTGCAGGAGAGAATTT TGATAAATTGTTAGCTGGAAAGCTGAGAGAGACTTTGAACATATCTGGACCACCTCTGAAGGCAGGGAAGACTCGAACCTTTTATGGTCT GCATCAGAATGCTGAACTGAAATTTAACTTCGGTGAAGAGGAATTTAAGTTTCCACCAAAAGATGGCTTTGTTGCTCTTTCCAAGGCACC GGATGGTTACATTGTCAAATCACAGCACTCAGGTAATGCACAGGTGACACAAACAAAGTTTCTCCCCAATGCTCCGAAAGCTCTCATTGT TGAACCTTCCCGGGAGTTAGCTGAACAAACTTTGAACAACATCAAGCAGTTTAAGAAATACATTGATAATCCTAAATTAAGGGAGCTTCT GATAATTGGAGGTGTTGCAGCCCGGGATCAGCTCTCTGTTTTGGAAAATGGAGTAGATATAGTTGTAGGTACTCCGGGAAGACTAGATGA CTTGGTGTCAACTGGAAAGCTGAACTTATCTCAAGTTAGATTCCTGGTCCTGGATGAAGCTGATGGGCTTCTTTCTCAAGGTTATTCTGA TTTTATAAATAGGATGCACAATCAGATTCCTCAGGTTACCTCTGATGGAAAAAGACTTCAGGTGATTGTTTGCTCTGCCACTTTGCATTC TTTCGATGTAAAGAAACTGTCCGAGAAGATAATGCATTTTCCTACATGGGTTGACTTAAAAGGAGAAGACTCTGTTCCAGATACTGTACA CCATGTTGTTGTCCCAGTAAATCCCAAAACTGACAGACTCTGGGAAAGGCTTGGAAAGAGCCACATTAGAACTGATGATGTACATGCAAA AGATAACACAAGACCTGGTGCTAATAGTCCAGAGATGTGGTCTGAAGCTATTAAAATCCTGAAAGGGGAGTATGCTGTCCGGGCAATCAA GGAACATAAGATGGATCAAGCAATTATCTTCTGTAGAACCAAAATTGACTGTGATAACTTGGAGCAGTACTTTATACAACAAGGAGGAGG ACCTGATAAAAAAGGACACCAGTTCTCATGTGTTTGTCTTCATGGTGACAGAAAGCCTCATGAGAGAAAGCAAAACTTGGAAAGATTTAA GAAAGGAGATGTAAGATTCTTGATTTGCACAGATGTAGCTGCTAGAGGAATTGATATCCACGGTGTTCCTTATGTTATAAATGTCACTCT GCCCGATGAAAAGCAAAACTACGTACATCGAATTGGCAGAGTAGGAAGAGCTGAAAGGATGGGTCTGGCAATTTCCCTGGTGGCAACAGA AAAAGAAAAGGTTTGGTACCATGTATGTAGCAGCCGTGGAAAAGGGTGTTATAACACAAGACTCAAGGAAGATGGAGGCTGTACCATATG GTACAACGAGATGCAGTTACTATCTGAGATAGAAGAACACCTGAACTGTACCATTTCTCAGGTTGAGCCGGATATAAAGGTACCAGTGGA TGAATTTGATGGGAAAGTTACCTACGGTCAGAAAAGGGCTGCTGGTGGTGGAAGCTATAAAGGCCATGTGGATATTTTGGCACCTACTGT TCAAGAGTTGGCTGCCCTTGAAAAGGAGGCGCAGACATCTTTCCTGCATCTTGGCTACCTTCCTAACCAGCTGTTCAGAACCTTCTGATT TTTACATTTACTGAATAAGATTTGAGTAATGAAAGTCTGTAGTCTTAAAACTCTAAAACAGTTGTACTGCTTCCAAGCAGCAGTATTTAT AGTAACGTAAGCTATTAATGCTAACTCTTGCATGTCAAGAAACATTAGTCTTAGGAATTCTTCAAAAAATGGCATCCCAATGAAAATAAA >44034_44034_4_LAP3-DDX1_LAP3_chr4_17583437_ENST00000226299_DDX1_chr2_15746274_ENST00000381341_length(amino acids)=627AA_BP=121 MRPESPAPRRARPPLSTCSLEGGARGRADKMFLLPLPAAGRVVVRRLAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFD KLLAGKLRETLNISGPPLKAGKTRTFYGLHQNAELKFNFGEEEFKFPPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVE PSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDF INRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKD NTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKK GDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWY -------------------------------------------------------------- >44034_44034_5_LAP3-DDX1_LAP3_chr4_17583437_ENST00000606142_DDX1_chr2_15746273_ENST00000233084_length(transcript)=1960nt_BP=244nt GCGAGTAGTCGTCCGACGTCTGGCCGTGAGACGTTTCGGGAGCCGGAGTCTCTCCACCGCAGACATGACGAAGGGCCTTGTTTTAGGAAT CTATTCCAAAGAAAAAGAAGATGATGTGCCACAGTTCACAAGTGCAGGAGAGAATTTTGATAAATTGTTAGCTGGAAAGCTGAGAGAGAC TTTGAACATATCTGGACCACCTCTGAAGGCAGGGAAGACTCGAACCTTTTATGGTCTGCATCAGAATGCTGAACTGAAATTTAACTTCGG TGAAGAGGAATTTAAGTTTCCACCAAAAGATGGCTTTGTTGCTCTTTCCAAGGCACCGGATGGTTACATTGTCAAATCACAGCACTCAGG TAATGCACAGGTGACACAAACAAAGTTTCTCCCCAATGCTCCGAAAGCTCTCATTGTTGAACCTTCCCGGGAGTTAGCTGAACAAACTTT GAACAACATCAAGCAGTTTAAGAAATACATTGATAATCCTAAATTAAGGGAGCTTCTGATAATTGGAGGTGTTGCAGCCCGGGATCAGCT CTCTGTTTTGGAAAATGGAGTAGATATAGTTGTAGGTACTCCGGGAAGACTAGATGACTTGGTGTCAACTGGAAAGCTGAACTTATCTCA AGTTAGATTCCTGGTCCTGGATGAAGCTGATGGGCTTCTTTCTCAAGGTTATTCTGATTTTATAAATAGGATGCACAATCAGATTCCTCA GGTTACCTCTGATGGAAAAAGACTTCAGGTGATTGTTTGCTCTGCCACTTTGCATTCTTTCGATGTAAAGAAACTGTCCGAGAAGATAAT GCATTTTCCTACATGGGTTGACTTAAAAGGAGAAGACTCTGTTCCAGATACTGTACACCATGTTGTTGTCCCAGTAAATCCCAAAACTGA CAGACTCTGGGAAAGGCTTGGAAAGAGCCACATTAGAACTGATGATGTACATGCAAAAGATAACACAAGACCTGGTGCTAATAGTCCAGA GATGTGGTCTGAAGCTATTAAAATCCTGAAAGGGGAGTATGCTGTCCGGGCAATCAAGGAACATAAGATGGATCAAGCAATTATCTTCTG TAGAACCAAAATTGACTGTGATAACTTGGAGCAGTACTTTATACAACAAGGAGGAGGACCTGATAAAAAAGGACACCAGTTCTCATGTGT TTGTCTTCATGGTGACAGAAAGCCTCATGAGAGAAAGCAAAACTTGGAAAGATTTAAGAAAGGAGATGTAAGATTCTTGATTTGCACAGA TGTAGCTGCTAGAGGAATTGATATCCACGGTGTTCCTTATGTTATAAATGTCACTCTGCCCGATGAAAAGCAAAACTACGTACATCGAAT TGGCAGAGTAGGAAGAGCTGAAAGGATGGGTCTGGCAATTTCCCTGGTGGCAACAGAAAAAGAAAAGGTTTGGTACCATGTATGTAGCAG CCGTGGAAAAGGGTGTTATAACACAAGACTCAAGGAAGATGGAGGCTGTACCATATGGTACAACGAGATGCAGTTACTATCTGAGATAGA AGAACACCTGAACTGTACCATTTCTCAGGTTGAGCCGGATATAAAGGTACCAGTGGATGAATTTGATGGGAAAGTTACCTACGGTCAGAA AAGGGCTGCTGGTGGTGGAAGCTATAAAGGCCATGTGGATATTTTGGCACCTACTGTTCAAGAGTTGGCTGCCCTTGAAAAGGAGGCGCA GACATCTTTCCTGCATCTTGGCTACCTTCCTAACCAGCTGTTCAGAACCTTCTGATTTTTACATTTACTGAATAAGATTTGAGTAATGAA AGTCTGTAGTCTTAAAACTCTAAAACAGTTGTACTGCTTCCAAGCAGCAGTATTTATAGTAACGTAAGCTATTAATGCTAACTCTTGCAT >44034_44034_5_LAP3-DDX1_LAP3_chr4_17583437_ENST00000606142_DDX1_chr2_15746273_ENST00000233084_length(amino acids)=581AA_BP=75 MAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFDKLLAGKLRETLNISGPPLKAGKTRTFYGLHQNAELKFNFGEEEFKF PPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVEPSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENG VDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWV DLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDC DNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRA ERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWYNEMQLLSEIEEHLNCTISQVEPDIKVPVDEFDGKVTYGQKRAAGGG -------------------------------------------------------------- >44034_44034_6_LAP3-DDX1_LAP3_chr4_17583437_ENST00000606142_DDX1_chr2_15746273_ENST00000381341_length(transcript)=1970nt_BP=244nt GCGAGTAGTCGTCCGACGTCTGGCCGTGAGACGTTTCGGGAGCCGGAGTCTCTCCACCGCAGACATGACGAAGGGCCTTGTTTTAGGAAT CTATTCCAAAGAAAAAGAAGATGATGTGCCACAGTTCACAAGTGCAGGAGAGAATTTTGATAAATTGTTAGCTGGAAAGCTGAGAGAGAC TTTGAACATATCTGGACCACCTCTGAAGGCAGGGAAGACTCGAACCTTTTATGGTCTGCATCAGAATGCTGAACTGAAATTTAACTTCGG TGAAGAGGAATTTAAGTTTCCACCAAAAGATGGCTTTGTTGCTCTTTCCAAGGCACCGGATGGTTACATTGTCAAATCACAGCACTCAGG TAATGCACAGGTGACACAAACAAAGTTTCTCCCCAATGCTCCGAAAGCTCTCATTGTTGAACCTTCCCGGGAGTTAGCTGAACAAACTTT GAACAACATCAAGCAGTTTAAGAAATACATTGATAATCCTAAATTAAGGGAGCTTCTGATAATTGGAGGTGTTGCAGCCCGGGATCAGCT CTCTGTTTTGGAAAATGGAGTAGATATAGTTGTAGGTACTCCGGGAAGACTAGATGACTTGGTGTCAACTGGAAAGCTGAACTTATCTCA AGTTAGATTCCTGGTCCTGGATGAAGCTGATGGGCTTCTTTCTCAAGGTTATTCTGATTTTATAAATAGGATGCACAATCAGATTCCTCA GGTTACCTCTGATGGAAAAAGACTTCAGGTGATTGTTTGCTCTGCCACTTTGCATTCTTTCGATGTAAAGAAACTGTCCGAGAAGATAAT GCATTTTCCTACATGGGTTGACTTAAAAGGAGAAGACTCTGTTCCAGATACTGTACACCATGTTGTTGTCCCAGTAAATCCCAAAACTGA CAGACTCTGGGAAAGGCTTGGAAAGAGCCACATTAGAACTGATGATGTACATGCAAAAGATAACACAAGACCTGGTGCTAATAGTCCAGA GATGTGGTCTGAAGCTATTAAAATCCTGAAAGGGGAGTATGCTGTCCGGGCAATCAAGGAACATAAGATGGATCAAGCAATTATCTTCTG TAGAACCAAAATTGACTGTGATAACTTGGAGCAGTACTTTATACAACAAGGAGGAGGACCTGATAAAAAAGGACACCAGTTCTCATGTGT TTGTCTTCATGGTGACAGAAAGCCTCATGAGAGAAAGCAAAACTTGGAAAGATTTAAGAAAGGAGATGTAAGATTCTTGATTTGCACAGA TGTAGCTGCTAGAGGAATTGATATCCACGGTGTTCCTTATGTTATAAATGTCACTCTGCCCGATGAAAAGCAAAACTACGTACATCGAAT TGGCAGAGTAGGAAGAGCTGAAAGGATGGGTCTGGCAATTTCCCTGGTGGCAACAGAAAAAGAAAAGGTTTGGTACCATGTATGTAGCAG CCGTGGAAAAGGGTGTTATAACACAAGACTCAAGGAAGATGGAGGCTGTACCATATGGTACAACGAGATGCAGTTACTATCTGAGATAGA AGAACACCTGAACTGTACCATTTCTCAGGTTGAGCCGGATATAAAGGTACCAGTGGATGAATTTGATGGGAAAGTTACCTACGGTCAGAA AAGGGCTGCTGGTGGTGGAAGCTATAAAGGCCATGTGGATATTTTGGCACCTACTGTTCAAGAGTTGGCTGCCCTTGAAAAGGAGGCGCA GACATCTTTCCTGCATCTTGGCTACCTTCCTAACCAGCTGTTCAGAACCTTCTGATTTTTACATTTACTGAATAAGATTTGAGTAATGAA AGTCTGTAGTCTTAAAACTCTAAAACAGTTGTACTGCTTCCAAGCAGCAGTATTTATAGTAACGTAAGCTATTAATGCTAACTCTTGCAT >44034_44034_6_LAP3-DDX1_LAP3_chr4_17583437_ENST00000606142_DDX1_chr2_15746273_ENST00000381341_length(amino acids)=581AA_BP=75 MAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFDKLLAGKLRETLNISGPPLKAGKTRTFYGLHQNAELKFNFGEEEFKF PPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVEPSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENG VDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWV DLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDC DNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRA ERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWYNEMQLLSEIEEHLNCTISQVEPDIKVPVDEFDGKVTYGQKRAAGGG -------------------------------------------------------------- >44034_44034_7_LAP3-DDX1_LAP3_chr4_17583437_ENST00000606142_DDX1_chr2_15746274_ENST00000233084_length(transcript)=1960nt_BP=244nt GCGAGTAGTCGTCCGACGTCTGGCCGTGAGACGTTTCGGGAGCCGGAGTCTCTCCACCGCAGACATGACGAAGGGCCTTGTTTTAGGAAT CTATTCCAAAGAAAAAGAAGATGATGTGCCACAGTTCACAAGTGCAGGAGAGAATTTTGATAAATTGTTAGCTGGAAAGCTGAGAGAGAC TTTGAACATATCTGGACCACCTCTGAAGGCAGGGAAGACTCGAACCTTTTATGGTCTGCATCAGAATGCTGAACTGAAATTTAACTTCGG TGAAGAGGAATTTAAGTTTCCACCAAAAGATGGCTTTGTTGCTCTTTCCAAGGCACCGGATGGTTACATTGTCAAATCACAGCACTCAGG TAATGCACAGGTGACACAAACAAAGTTTCTCCCCAATGCTCCGAAAGCTCTCATTGTTGAACCTTCCCGGGAGTTAGCTGAACAAACTTT GAACAACATCAAGCAGTTTAAGAAATACATTGATAATCCTAAATTAAGGGAGCTTCTGATAATTGGAGGTGTTGCAGCCCGGGATCAGCT CTCTGTTTTGGAAAATGGAGTAGATATAGTTGTAGGTACTCCGGGAAGACTAGATGACTTGGTGTCAACTGGAAAGCTGAACTTATCTCA AGTTAGATTCCTGGTCCTGGATGAAGCTGATGGGCTTCTTTCTCAAGGTTATTCTGATTTTATAAATAGGATGCACAATCAGATTCCTCA GGTTACCTCTGATGGAAAAAGACTTCAGGTGATTGTTTGCTCTGCCACTTTGCATTCTTTCGATGTAAAGAAACTGTCCGAGAAGATAAT GCATTTTCCTACATGGGTTGACTTAAAAGGAGAAGACTCTGTTCCAGATACTGTACACCATGTTGTTGTCCCAGTAAATCCCAAAACTGA CAGACTCTGGGAAAGGCTTGGAAAGAGCCACATTAGAACTGATGATGTACATGCAAAAGATAACACAAGACCTGGTGCTAATAGTCCAGA GATGTGGTCTGAAGCTATTAAAATCCTGAAAGGGGAGTATGCTGTCCGGGCAATCAAGGAACATAAGATGGATCAAGCAATTATCTTCTG TAGAACCAAAATTGACTGTGATAACTTGGAGCAGTACTTTATACAACAAGGAGGAGGACCTGATAAAAAAGGACACCAGTTCTCATGTGT TTGTCTTCATGGTGACAGAAAGCCTCATGAGAGAAAGCAAAACTTGGAAAGATTTAAGAAAGGAGATGTAAGATTCTTGATTTGCACAGA TGTAGCTGCTAGAGGAATTGATATCCACGGTGTTCCTTATGTTATAAATGTCACTCTGCCCGATGAAAAGCAAAACTACGTACATCGAAT TGGCAGAGTAGGAAGAGCTGAAAGGATGGGTCTGGCAATTTCCCTGGTGGCAACAGAAAAAGAAAAGGTTTGGTACCATGTATGTAGCAG CCGTGGAAAAGGGTGTTATAACACAAGACTCAAGGAAGATGGAGGCTGTACCATATGGTACAACGAGATGCAGTTACTATCTGAGATAGA AGAACACCTGAACTGTACCATTTCTCAGGTTGAGCCGGATATAAAGGTACCAGTGGATGAATTTGATGGGAAAGTTACCTACGGTCAGAA AAGGGCTGCTGGTGGTGGAAGCTATAAAGGCCATGTGGATATTTTGGCACCTACTGTTCAAGAGTTGGCTGCCCTTGAAAAGGAGGCGCA GACATCTTTCCTGCATCTTGGCTACCTTCCTAACCAGCTGTTCAGAACCTTCTGATTTTTACATTTACTGAATAAGATTTGAGTAATGAA AGTCTGTAGTCTTAAAACTCTAAAACAGTTGTACTGCTTCCAAGCAGCAGTATTTATAGTAACGTAAGCTATTAATGCTAACTCTTGCAT >44034_44034_7_LAP3-DDX1_LAP3_chr4_17583437_ENST00000606142_DDX1_chr2_15746274_ENST00000233084_length(amino acids)=581AA_BP=75 MAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFDKLLAGKLRETLNISGPPLKAGKTRTFYGLHQNAELKFNFGEEEFKF PPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVEPSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENG VDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWV DLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDC DNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRA ERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWYNEMQLLSEIEEHLNCTISQVEPDIKVPVDEFDGKVTYGQKRAAGGG -------------------------------------------------------------- >44034_44034_8_LAP3-DDX1_LAP3_chr4_17583437_ENST00000606142_DDX1_chr2_15746274_ENST00000381341_length(transcript)=1970nt_BP=244nt GCGAGTAGTCGTCCGACGTCTGGCCGTGAGACGTTTCGGGAGCCGGAGTCTCTCCACCGCAGACATGACGAAGGGCCTTGTTTTAGGAAT CTATTCCAAAGAAAAAGAAGATGATGTGCCACAGTTCACAAGTGCAGGAGAGAATTTTGATAAATTGTTAGCTGGAAAGCTGAGAGAGAC TTTGAACATATCTGGACCACCTCTGAAGGCAGGGAAGACTCGAACCTTTTATGGTCTGCATCAGAATGCTGAACTGAAATTTAACTTCGG TGAAGAGGAATTTAAGTTTCCACCAAAAGATGGCTTTGTTGCTCTTTCCAAGGCACCGGATGGTTACATTGTCAAATCACAGCACTCAGG TAATGCACAGGTGACACAAACAAAGTTTCTCCCCAATGCTCCGAAAGCTCTCATTGTTGAACCTTCCCGGGAGTTAGCTGAACAAACTTT GAACAACATCAAGCAGTTTAAGAAATACATTGATAATCCTAAATTAAGGGAGCTTCTGATAATTGGAGGTGTTGCAGCCCGGGATCAGCT CTCTGTTTTGGAAAATGGAGTAGATATAGTTGTAGGTACTCCGGGAAGACTAGATGACTTGGTGTCAACTGGAAAGCTGAACTTATCTCA AGTTAGATTCCTGGTCCTGGATGAAGCTGATGGGCTTCTTTCTCAAGGTTATTCTGATTTTATAAATAGGATGCACAATCAGATTCCTCA GGTTACCTCTGATGGAAAAAGACTTCAGGTGATTGTTTGCTCTGCCACTTTGCATTCTTTCGATGTAAAGAAACTGTCCGAGAAGATAAT GCATTTTCCTACATGGGTTGACTTAAAAGGAGAAGACTCTGTTCCAGATACTGTACACCATGTTGTTGTCCCAGTAAATCCCAAAACTGA CAGACTCTGGGAAAGGCTTGGAAAGAGCCACATTAGAACTGATGATGTACATGCAAAAGATAACACAAGACCTGGTGCTAATAGTCCAGA GATGTGGTCTGAAGCTATTAAAATCCTGAAAGGGGAGTATGCTGTCCGGGCAATCAAGGAACATAAGATGGATCAAGCAATTATCTTCTG TAGAACCAAAATTGACTGTGATAACTTGGAGCAGTACTTTATACAACAAGGAGGAGGACCTGATAAAAAAGGACACCAGTTCTCATGTGT TTGTCTTCATGGTGACAGAAAGCCTCATGAGAGAAAGCAAAACTTGGAAAGATTTAAGAAAGGAGATGTAAGATTCTTGATTTGCACAGA TGTAGCTGCTAGAGGAATTGATATCCACGGTGTTCCTTATGTTATAAATGTCACTCTGCCCGATGAAAAGCAAAACTACGTACATCGAAT TGGCAGAGTAGGAAGAGCTGAAAGGATGGGTCTGGCAATTTCCCTGGTGGCAACAGAAAAAGAAAAGGTTTGGTACCATGTATGTAGCAG CCGTGGAAAAGGGTGTTATAACACAAGACTCAAGGAAGATGGAGGCTGTACCATATGGTACAACGAGATGCAGTTACTATCTGAGATAGA AGAACACCTGAACTGTACCATTTCTCAGGTTGAGCCGGATATAAAGGTACCAGTGGATGAATTTGATGGGAAAGTTACCTACGGTCAGAA AAGGGCTGCTGGTGGTGGAAGCTATAAAGGCCATGTGGATATTTTGGCACCTACTGTTCAAGAGTTGGCTGCCCTTGAAAAGGAGGCGCA GACATCTTTCCTGCATCTTGGCTACCTTCCTAACCAGCTGTTCAGAACCTTCTGATTTTTACATTTACTGAATAAGATTTGAGTAATGAA AGTCTGTAGTCTTAAAACTCTAAAACAGTTGTACTGCTTCCAAGCAGCAGTATTTATAGTAACGTAAGCTATTAATGCTAACTCTTGCAT >44034_44034_8_LAP3-DDX1_LAP3_chr4_17583437_ENST00000606142_DDX1_chr2_15746274_ENST00000381341_length(amino acids)=581AA_BP=75 MAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFDKLLAGKLRETLNISGPPLKAGKTRTFYGLHQNAELKFNFGEEEFKF PPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVEPSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENG VDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWV DLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDC DNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRA ERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWYNEMQLLSEIEEHLNCTISQVEPDIKVPVDEFDGKVTYGQKRAAGGG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for LAP3-DDX1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | DDX1 | chr4:17583437 | chr2:15746273 | ENST00000233084 | 10 | 26 | 1_448 | 234.0 | 741.0 | dsRNA | |
| Tgene | DDX1 | chr4:17583437 | chr2:15746273 | ENST00000381341 | 11 | 27 | 1_448 | 234.0 | 741.0 | dsRNA | |
| Tgene | DDX1 | chr4:17583437 | chr2:15746274 | ENST00000233084 | 10 | 26 | 1_448 | 234.0 | 741.0 | dsRNA | |
| Tgene | DDX1 | chr4:17583437 | chr2:15746274 | ENST00000381341 | 11 | 27 | 1_448 | 234.0 | 741.0 | dsRNA |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for LAP3-DDX1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for LAP3-DDX1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | LAP3 | C0019193 | Hepatitis, Toxic | 1 | CTD_human |
| Hgene | LAP3 | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human |
| Hgene | LAP3 | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human |
| Hgene | LAP3 | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human |
| Hgene | LAP3 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
| Hgene | LAP3 | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |
| Tgene | C0013146 | Drug abuse | 1 | CTD_human | |
| Tgene | C0013170 | Drug habituation | 1 | CTD_human | |
| Tgene | C0013222 | Drug Use Disorders | 1 | CTD_human | |
| Tgene | C0014173 | Endometrial Hyperplasia | 1 | CTD_human | |
| Tgene | C0029231 | Organic Mental Disorders, Substance-Induced | 1 | CTD_human | |
| Tgene | C0038580 | Substance Dependence | 1 | CTD_human | |
| Tgene | C0038586 | Substance Use Disorders | 1 | CTD_human | |
| Tgene | C0236969 | Substance-Related Disorders | 1 | CTD_human | |
| Tgene | C0349578 | Complex Endometrial Hyperplasia | 1 | CTD_human | |
| Tgene | C0349579 | Atypical Endometrial Hyperplasia | 1 | CTD_human | |
| Tgene | C0456483 | Simple Endometrial Hyperplasia | 1 | CTD_human | |
| Tgene | C0740858 | Substance abuse problem | 1 | CTD_human | |
| Tgene | C1510472 | Drug Dependence | 1 | CTD_human | |
| Tgene | C4316881 | Prescription Drug Abuse | 1 | CTD_human |
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