Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ANAPC5-G6PD (FusionGDB2 ID:HG51433TG2539)

Fusion Gene Summary for ANAPC5-G6PD

check button Fusion gene summary
Fusion gene informationFusion gene name: ANAPC5-G6PD
Fusion gene ID: hg51433tg2539
HgeneTgene
Gene symbol

ANAPC5

G6PD

Gene ID

51433

2539

Gene nameanaphase promoting complex subunit 5glucose-6-phosphate dehydrogenase
SynonymsAPC5G6PD1
Cytomap('ANAPC5')('G6PD')

12q24.31

Xq28

Type of geneprotein-codingprotein-coding
Descriptionanaphase-promoting complex subunit 5cyclosome subunit 5glucose-6-phosphate 1-dehydrogenaseepididymis secretory sperm binding protein
Modification date2020031320200313
UniProtAcc.

P11413

Ensembl transtripts involved in fusion geneENST00000261819, ENST00000344395, 
ENST00000441917, ENST00000535482, 
ENST00000536366, ENST00000541887, 
ENST00000544314, 
Fusion gene scores* DoF score9 X 11 X 6=5944 X 7 X 2=56
# samples 118
** MAII scorelog2(11/594*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/56*10)=0.514573172829758
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ANAPC5 [Title/Abstract] AND G6PD [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANAPC5(121746247)-G6PD(153760136), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANAPC5

GO:0070979

protein K11-linked ubiquitination

18485873

TgeneG6PD

GO:0006098

pentose-phosphate shunt

2297768

TgeneG6PD

GO:0006739

NADP metabolic process

15858258

TgeneG6PD

GO:0019322

pentose biosynthetic process

5643703

TgeneG6PD

GO:0051156

glucose 6-phosphate metabolic process

15858258



check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACA419747ANAPC5chr12

121746247

+G6PDchrX

153760136

+


Top

Fusion Gene ORF analysis for ANAPC5-G6PD

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000261819ENST00000393562ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-3UTRENST00000344395ENST00000393562ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-3UTRENST00000441917ENST00000393562ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-3UTRENST00000535482ENST00000393562ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-3UTRENST00000536366ENST00000393562ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-3UTRENST00000541887ENST00000393562ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-3UTRENST00000544314ENST00000393562ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-intronENST00000261819ENST00000369620ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-intronENST00000261819ENST00000393564ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-intronENST00000261819ENST00000497281ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-intronENST00000344395ENST00000369620ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-intronENST00000344395ENST00000393564ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-intronENST00000344395ENST00000497281ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-intronENST00000441917ENST00000369620ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-intronENST00000441917ENST00000393564ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-intronENST00000441917ENST00000497281ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-intronENST00000535482ENST00000369620ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-intronENST00000535482ENST00000393564ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-intronENST00000535482ENST00000497281ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-intronENST00000536366ENST00000369620ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-intronENST00000536366ENST00000393564ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-intronENST00000536366ENST00000497281ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-intronENST00000541887ENST00000369620ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-intronENST00000541887ENST00000393564ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-intronENST00000541887ENST00000497281ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-intronENST00000544314ENST00000369620ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-intronENST00000544314ENST00000393564ANAPC5chr12

121746247

+G6PDchrX

153760136

+
intron-intronENST00000544314ENST00000497281ANAPC5chr12

121746247

+G6PDchrX

153760136

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for ANAPC5-G6PD


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


Top

Fusion Protein Features for ANAPC5-G6PD


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:121746247/:153760136)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.G6PD

P11413

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. {ECO:0000269|PubMed:15858258, ECO:0000269|PubMed:24769394, ECO:0000269|PubMed:26479991, ECO:0000269|PubMed:743300}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for ANAPC5-G6PD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for ANAPC5-G6PD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ANAPC5-G6PD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneG6PDP11413DB03085Glycolic acidInhibitorSmall moleculeApproved|Investigational

Top

Related Diseases for ANAPC5-G6PD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC2720289ANEMIA, NONSPHEROCYTIC HEMOLYTIC, DUE TO G6PD DEFICIENCY21CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0005586Bipolar Disorder5PSYGENET
TgeneC0002878Anemia, Hemolytic4CTD_human;GENOMICS_ENGLAND
TgeneC0002879Anemia, Hemolytic, Acquired3CTD_human
TgeneC0002889Anemia, Microangiopathic3CTD_human
TgeneC0022660Kidney Failure, Acute3CTD_human
TgeneC0221021Microangiopathic hemolytic anemia3CTD_human
TgeneC1565662Acute Kidney Insufficiency3CTD_human
TgeneC2609414Acute kidney injury3CTD_human
TgeneC2939465Deficiency of glucose-6-phosphate dehydrogenase3CTD_human
TgeneC0002882Anemia, Hemolytic, Congenital Nonspherocytic2CTD_human
TgeneC0015702Favism2CTD_human
TgeneC0019054Hemolysis (disorder)2CTD_human
TgeneC0235574Intravascular hemolysis2CTD_human
TgeneC0312854Extravascular Hemolysis2CTD_human
TgeneC0520572Enzymopathy2GENOMICS_ENGLAND
TgeneC0011616Contact Dermatitis1CTD_human
TgeneC0018203Chronic granulomatous disease1CTD_human
TgeneC0031306Phagocyte Bactericidal Dysfunction1CTD_human
TgeneC0162351Contact hypersensitivity1CTD_human
TgeneC1844376Granulomatous Disease, Chronic, X-Linked1CTD_human
TgeneC3661525Autosomal Recessive Chronic Granulomatous Disease1CTD_human
TgeneC3714514Infection1GENOMICS_ENGLAND