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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:WWOX-GNAS (FusionGDB2 ID:HG51741TG2778)

Fusion Gene Summary for WWOX-GNAS

Fusion gene summary

Fusion gene information	Fusion gene name: WWOX-GNAS
	Fusion gene ID: hg51741tg2778
		Hgene	Tgene
	Gene symbol	WWOX	GNAS
	Gene ID	51741	2778
	Gene name	WW domain containing oxidoreductase	GNAS complex locus
	Synonyms	D16S432E\|EIEE28\|FOR\|FRA16D\|HHCMA56\|PRO0128\|SCAR12\|SDR41C1\|WOX1	AHO\|C20orf45\|GNAS1\|GPSA\|GSA\|GSP\|NESP\|PITA3\|POH\|SCG6\|SgVI
	Cytomap	('WWOX')('GNAS') 16q23.1-q23.2	20q13.32
	Type of gene	protein-coding	protein-coding
	Description	WW domain-containing oxidoreductaseWW domain-containing protein WWOXfragile site FRA16D oxidoreductaseshort chain dehydrogenase/reductase family 41C member 1	protein ALEXprotein GNASprotein SCG6 (secretogranin VI)G protein subunit alpha Sadenylate cyclase-stimulating G alpha proteinalternative gene product encoded by XL-exonextra large alphas proteinguanine nucleotide binding protein (G protein), alpha
	Modification date	20200313	20200329
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000408984, ENST00000566780, ENST00000355860, ENST00000402655, ENST00000406884, ENST00000539474, ENST00000565791, ENST00000569818,
Fusion gene scores	* DoF score	26 X 26 X 8=5408	111 X 41 X 18=81918
	# samples	31	111
	** MAII score	log2(31/5408*10)=-4.12475503100795 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(111/81918*10)=-6.20554891117303 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: WWOX [Title/Abstract] AND GNAS [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	WWOX(78466649)-GNAS(57470667), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	WWOX	GO:0030178	negative regulation of Wnt signaling pathway	19465938
Hgene	WWOX	GO:0071560	cellular response to transforming growth factor beta stimulus	19366691

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-27-1832-01A	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+

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Fusion Gene ORF analysis for WWOX-GNAS

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000408984	ENST00000313949	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-3UTR	ENST00000408984	ENST00000371075	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-3UTR	ENST00000408984	ENST00000371098	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-3UTR	ENST00000408984	ENST00000371100	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-3UTR	ENST00000408984	ENST00000464624	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-3UTR	ENST00000566780	ENST00000313949	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-3UTR	ENST00000566780	ENST00000371075	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-3UTR	ENST00000566780	ENST00000371098	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-3UTR	ENST00000566780	ENST00000371100	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-3UTR	ENST00000566780	ENST00000464624	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-intron	ENST00000408984	ENST00000265620	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-intron	ENST00000408984	ENST00000306090	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-intron	ENST00000408984	ENST00000306120	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-intron	ENST00000408984	ENST00000354359	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-intron	ENST00000408984	ENST00000371081	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-intron	ENST00000408984	ENST00000371085	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-intron	ENST00000408984	ENST00000371095	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-intron	ENST00000408984	ENST00000371099	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-intron	ENST00000408984	ENST00000371102	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-intron	ENST00000566780	ENST00000265620	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-intron	ENST00000566780	ENST00000306090	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-intron	ENST00000566780	ENST00000306120	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-intron	ENST00000566780	ENST00000354359	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-intron	ENST00000566780	ENST00000371081	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-intron	ENST00000566780	ENST00000371085	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-intron	ENST00000566780	ENST00000371095	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-intron	ENST00000566780	ENST00000371099	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
5CDS-intron	ENST00000566780	ENST00000371102	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000355860	ENST00000313949	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000355860	ENST00000371075	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000355860	ENST00000371098	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000355860	ENST00000371100	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000355860	ENST00000464624	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000402655	ENST00000313949	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000402655	ENST00000371075	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000402655	ENST00000371098	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000402655	ENST00000371100	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000402655	ENST00000464624	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000406884	ENST00000313949	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000406884	ENST00000371075	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000406884	ENST00000371098	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000406884	ENST00000371100	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000406884	ENST00000464624	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000539474	ENST00000313949	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000539474	ENST00000371075	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000539474	ENST00000371098	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000539474	ENST00000371100	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000539474	ENST00000464624	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000565791	ENST00000313949	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000565791	ENST00000371075	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000565791	ENST00000371098	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000565791	ENST00000371100	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000565791	ENST00000464624	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000569818	ENST00000313949	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000569818	ENST00000371075	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000569818	ENST00000371098	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000569818	ENST00000371100	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000569818	ENST00000464624	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000355860	ENST00000265620	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000355860	ENST00000306090	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000355860	ENST00000306120	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000355860	ENST00000354359	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000355860	ENST00000371081	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000355860	ENST00000371085	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000355860	ENST00000371095	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000355860	ENST00000371099	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000355860	ENST00000371102	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000402655	ENST00000265620	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000402655	ENST00000306090	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000402655	ENST00000306120	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000402655	ENST00000354359	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000402655	ENST00000371081	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000402655	ENST00000371085	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000402655	ENST00000371095	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000402655	ENST00000371099	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000402655	ENST00000371102	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000406884	ENST00000265620	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000406884	ENST00000306090	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000406884	ENST00000306120	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000406884	ENST00000354359	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000406884	ENST00000371081	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000406884	ENST00000371085	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000406884	ENST00000371095	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000406884	ENST00000371099	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000406884	ENST00000371102	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000539474	ENST00000265620	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000539474	ENST00000306090	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000539474	ENST00000306120	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000539474	ENST00000354359	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000539474	ENST00000371081	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000539474	ENST00000371085	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000539474	ENST00000371095	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000539474	ENST00000371099	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000539474	ENST00000371102	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000565791	ENST00000265620	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000565791	ENST00000306090	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000565791	ENST00000306120	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000565791	ENST00000354359	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000565791	ENST00000371081	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000565791	ENST00000371085	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000565791	ENST00000371095	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000565791	ENST00000371099	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000565791	ENST00000371102	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000569818	ENST00000265620	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000569818	ENST00000306090	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000569818	ENST00000306120	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000569818	ENST00000354359	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000569818	ENST00000371081	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000569818	ENST00000371085	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000569818	ENST00000371095	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000569818	ENST00000371099	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+
intron-intron	ENST00000569818	ENST00000371102	WWOX	chr16	78466649	+	GNAS	chr20	57470667	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for WWOX-GNAS

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
WWOX	chr16	78466649	+	GNAS	chr20	57470666	+	1.24E-07	0.9999999
WWOX	chr16	78466649	+	GNAS	chr20	57470666	+	1.24E-07	0.9999999

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for WWOX-GNAS

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:78466649/:57470667)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for WWOX-GNAS

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for WWOX-GNAS

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for WWOX-GNAS

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for WWOX-GNAS

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	WWOX	C0279626	Squamous cell carcinoma of esophagus	3	CTD_human;ORPHANET
Hgene	WWOX	C3280452	SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 12	2	GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	WWOX	C4015519	EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 28	2	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	WWOX	C0002395	Alzheimer's Disease	1	CTD_human
Hgene	WWOX	C0006142	Malignant neoplasm of breast	1	CTD_human
Hgene	WWOX	C0007137	Squamous cell carcinoma	1	CTD_human
Hgene	WWOX	C0011265	Presenile dementia	1	CTD_human
Hgene	WWOX	C0024623	Malignant neoplasm of stomach	1	CTD_human
Hgene	WWOX	C0038356	Stomach Neoplasms	1	CTD_human
Hgene	WWOX	C0042076	Urologic Neoplasms	1	CTD_human
Hgene	WWOX	C0087031	Juvenile-Onset Still Disease	1	CTD_human
Hgene	WWOX	C0276496	Familial Alzheimer Disease (FAD)	1	CTD_human
Hgene	WWOX	C0494463	Alzheimer Disease, Late Onset	1	CTD_human
Hgene	WWOX	C0546126	Acute Confusional Senile Dementia	1	CTD_human
Hgene	WWOX	C0678222	Breast Carcinoma	1	CTD_human
Hgene	WWOX	C0750900	Alzheimer's Disease, Focal Onset	1	CTD_human
Hgene	WWOX	C0750901	Alzheimer Disease, Early Onset	1	CTD_human
Hgene	WWOX	C0751571	Cancer of Urinary Tract	1	CTD_human
Hgene	WWOX	C1257931	Mammary Neoplasms, Human	1	CTD_human
Hgene	WWOX	C1458155	Mammary Neoplasms	1	CTD_human
Hgene	WWOX	C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human
Hgene	WWOX	C3495559	Juvenile arthritis	1	CTD_human
Hgene	WWOX	C3714758	Juvenile psoriatic arthritis	1	CTD_human
Hgene	WWOX	C4510744	46,XY partial gonadal dysgenesis	1	ORPHANET
Hgene	WWOX	C4552091	Polyarthritis, Juvenile, Rheumatoid Factor Negative	1	CTD_human
Hgene	WWOX	C4704862	Polyarthritis, Juvenile, Rheumatoid Factor Positive	1	CTD_human
Hgene	WWOX	C4704874	Mammary Carcinoma, Human	1	CTD_human
Tgene		C3494506	Pseudohypoparathyroidism, Type Ia	17	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C0242292	McCune-Albright Syndrome	7	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C0016065	Polyostotic fibrous dysplasia	5	CTD_human;ORPHANET
Tgene		C1864100	PSEUDOHYPOPARATHYROIDISM, TYPE IB	5	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene		C2931404	Albright's hereditary osteodystrophy	4	CTD_human;GENOMICS_ENGLAND
Tgene		C0033806	Pseudohypoparathyroidism	3	CTD_human
Tgene		C0334041	Osteoma cutis	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C0014130	Endocrine System Diseases	2	CTD_human
Tgene		C0016064	Fibrous Dysplasia, Monostotic	2	ORPHANET
Tgene		C0034013	Precocious Puberty	2	CTD_human
Tgene		C0221263	Cafe-au-Lait Spots	2	CTD_human
Tgene		C0271527	Cryptogenic sexual precocity	2	CTD_human
Tgene		C0342543	Central Precocious Puberty	2	CTD_human
Tgene		C1504412	Testotoxicosis	2	CTD_human
Tgene		C1857451	Acth-Independent Macronodular Adrenal Hyperplasia	2	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C2932716	Pseudohypoparathyroidism Type 1C	2	GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C0001206	Acromegaly	1	CTD_human
Tgene		C0001624	Adrenal Gland Neoplasms	1	CTD_human
Tgene		C0003129	Anoxemia	1	CTD_human
Tgene		C0003130	Anoxia	1	CTD_human
Tgene		C0008370	Cholestasis	1	GENOMICS_ENGLAND
Tgene		C0009438	Common Bile Duct Calculi	1	CTD_human
Tgene		C0011573	Endogenous depression	1	PSYGENET
Tgene		C0019087	Hemorrhagic Disorders	1	CTD_human
Tgene		C0020538	Hypertensive disease	1	CTD_human
Tgene		C0020796	Profound Mental Retardation	1	CTD_human
Tgene		C0021655	Insulin Resistance	1	CTD_human
Tgene		C0023897	Liver Diseases, Parasitic	1	CTD_human
Tgene		C0025363	Mental Retardation, Psychosocial	1	CTD_human
Tgene		C0027819	Neuroblastoma	1	CTD_human
Tgene		C0028754	Obesity	1	CTD_human
Tgene		C0029396	Heterotopic Ossification	1	CTD_human
Tgene		C0032460	Polycystic Ovary Syndrome	1	CTD_human
Tgene		C0033835	Pseudopseudohypoparathyroidism	1	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene		C0035204	Respiration Disorders	1	CTD_human
Tgene		C0036341	Schizophrenia	1	PSYGENET
Tgene		C0038587	Substance Withdrawal Syndrome	1	CTD_human
Tgene		C0039231	Tachycardia	1	CTD_human
Tgene		C0080203	Tachyarrhythmia	1	CTD_human
Tgene		C0086189	Drug Withdrawal Symptoms	1	CTD_human
Tgene		C0087169	Withdrawal Symptoms	1	CTD_human
Tgene		C0206698	Cholangiocarcinoma	1	CTD_human
Tgene		C0221357	Brachydactyly	1	CTD_human
Tgene		C0242184	Hypoxia	1	CTD_human
Tgene		C0242216	Biliary calculi	1	CTD_human
Tgene		C0345905	Intrahepatic Cholangiocarcinoma	1	CTD_human
Tgene		C0346302	Growth Hormone-Secreting Pituitary Adenoma	1	CTD_human
Tgene		C0700292	Hypoxemia	1	CTD_human
Tgene		C0750887	Adrenal Cancer	1	CTD_human
Tgene		C0917816	Mental deficiency	1	CTD_human
Tgene		C0920563	Insulin Sensitivity	1	CTD_human
Tgene		C1136382	Sclerocystic Ovaries	1	CTD_human
Tgene		C2932715	Pseudohypoparathyroidism Type 1B	1	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene		C3489630	Somatotrophinoma, Familial	1	CTD_human
Tgene		C3697137	Fibrous dysplasia of bone with intramuscular myxoma	1	ORPHANET
Tgene		C3714756	Intellectual Disability	1	CTD_human
Tgene		C3805278	Extrahepatic Cholangiocarcinoma	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:WWOX-GNAS (FusionGDB2 ID:HG51741TG2778)

Fusion Gene Summary for WWOX-GNAS

Fusion Gene ORF analysis for WWOX-GNAS

Fusion Genomic Features for WWOX-GNAS

Fusion Protein Features for WWOX-GNAS

Fusion Gene Sequence for WWOX-GNAS

Fusion Gene PPI Analysis for WWOX-GNAS

Related Drugs for WWOX-GNAS

Related Diseases for WWOX-GNAS

Fusion Gene Studies
in Kim Lab