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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BRWD1-SMC1A (FusionGDB2 ID:HG54014TG8243)

Fusion Gene Summary for BRWD1-SMC1A

check button Fusion gene summary
Fusion gene informationFusion gene name: BRWD1-SMC1A
Fusion gene ID: hg54014tg8243
HgeneTgene
Gene symbol

BRWD1

SMC1A

Gene ID

54014

8243

Gene namebromodomain and WD repeat domain containing 1structural maintenance of chromosomes 1A
SynonymsC21orf107|DCAF19|N143|WDR9|WRD9CDLS2|DXS423E|SB1.8|SMC1|SMC1L1|SMC1alpha|SMCB
Cytomap('BRWD1')('SMC1A')

21q22.2

Xp11.22

Type of geneprotein-codingprotein-coding
Descriptionbromodomain and WD repeat-containing protein 1WD repeat protein WDR9-form2WD repeat-containing protein 9transcriptional unit N143structural maintenance of chromosomes protein 1ASMC protein 1ASMC-1-alphaSMC1 (structural maintenance of chromosomes 1, yeast)-like 1epididymis secretory sperm binding proteinsegregation of mitotic chromosomes 1
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000333229, ENST00000380800, 
ENST00000341322, ENST00000342449, 
ENST00000470108, 
Fusion gene scores* DoF score28 X 28 X 10=78407 X 6 X 4=168
# samples 327
** MAII scorelog2(32/7840*10)=-4.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BRWD1 [Title/Abstract] AND SMC1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBRWD1(40568424)-SMC1A(53442118), # samples:3
Anticipated loss of major functional domain due to fusion event.BRWD1-SMC1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BRWD1-SMC1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BRWD1-SMC1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BRWD1-SMC1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSMC1A

GO:0072423

response to DNA damage checkpoint signaling

11877377


check buttonFusion gene breakpoints across BRWD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SMC1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-55-6987-01ABRWD1chr21

40568424

-SMC1AchrX

53442118

-


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Fusion Gene ORF analysis for BRWD1-SMC1A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000333229ENST00000375340BRWD1chr21

40568424

-SMC1AchrX

53442118

-
5CDS-intronENST00000333229ENST00000469129BRWD1chr21

40568424

-SMC1AchrX

53442118

-
5CDS-intronENST00000380800ENST00000375340BRWD1chr21

40568424

-SMC1AchrX

53442118

-
5CDS-intronENST00000380800ENST00000469129BRWD1chr21

40568424

-SMC1AchrX

53442118

-
In-frameENST00000333229ENST00000322213BRWD1chr21

40568424

-SMC1AchrX

53442118

-
In-frameENST00000380800ENST00000322213BRWD1chr21

40568424

-SMC1AchrX

53442118

-
intron-3CDSENST00000341322ENST00000322213BRWD1chr21

40568424

-SMC1AchrX

53442118

-
intron-3CDSENST00000342449ENST00000322213BRWD1chr21

40568424

-SMC1AchrX

53442118

-
intron-3CDSENST00000470108ENST00000322213BRWD1chr21

40568424

-SMC1AchrX

53442118

-
intron-intronENST00000341322ENST00000375340BRWD1chr21

40568424

-SMC1AchrX

53442118

-
intron-intronENST00000341322ENST00000469129BRWD1chr21

40568424

-SMC1AchrX

53442118

-
intron-intronENST00000342449ENST00000375340BRWD1chr21

40568424

-SMC1AchrX

53442118

-
intron-intronENST00000342449ENST00000469129BRWD1chr21

40568424

-SMC1AchrX

53442118

-
intron-intronENST00000470108ENST00000375340BRWD1chr21

40568424

-SMC1AchrX

53442118

-
intron-intronENST00000470108ENST00000469129BRWD1chr21

40568424

-SMC1AchrX

53442118

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000333229BRWD1chr2140568424-ENST00000322213SMC1AchrX53442118-164466899235104913418
ENST00000380800BRWD1chr2140568424-ENST00000322213SMC1AchrX53442118-1621766706102623418

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000333229ENST00000322213BRWD1chr2140568424-SMC1AchrX53442118-0.0007016180.99929833
ENST00000380800ENST00000322213BRWD1chr2140568424-SMC1AchrX53442118-0.0005430620.99945694

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Fusion Genomic Features for BRWD1-SMC1A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for BRWD1-SMC1A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:40568424/chrX:53442118)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-41421539_154821902321.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-41421687_169221902321.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-4142661_66821902321.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-4142821_82421902321.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-41421539_154821902200.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-41421687_169221902200.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-4142661_66821902200.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-4142821_82421902200.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-41421177_124721902321.0DomainBromo 1
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-41421330_140021902321.0DomainBromo 2
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-41421177_124721902200.0DomainBromo 1
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-41421330_140021902200.0DomainBromo 2
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-4142184_22321902321.0RepeatNote=WD 1
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-4142226_26521902321.0RepeatNote=WD 2
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-4142268_31121902321.0RepeatNote=WD 3
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-4142322_36521902321.0RepeatNote=WD 4
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-4142366_40521902321.0RepeatNote=WD 5
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-4142424_46321902321.0RepeatNote=WD 6
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-4142466_50621902321.0RepeatNote=WD 7
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-4142514_55321902321.0RepeatNote=WD 8
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-4142184_22321902200.0RepeatNote=WD 1
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-4142226_26521902200.0RepeatNote=WD 2
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-4142268_31121902200.0RepeatNote=WD 3
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-4142322_36521902200.0RepeatNote=WD 4
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-4142366_40521902200.0RepeatNote=WD 5
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-4142424_46321902200.0RepeatNote=WD 6
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-4142466_50621902200.0RepeatNote=WD 7
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-4142514_55321902200.0RepeatNote=WD 8
TgeneSMC1Achr21:40568424chrX:53442118ENST00000322213025104_124361234.0Coiled coilOntology_term=ECO:0000255
TgeneSMC1Achr21:40568424chrX:53442118ENST00000322213025163_503361234.0Coiled coilOntology_term=ECO:0000255
TgeneSMC1Achr21:40568424chrX:53442118ENST00000322213025660_935361234.0Coiled coilOntology_term=ECO:0000255
TgeneSMC1Achr21:40568424chrX:53442118ENST00000322213025991_1068361234.0Coiled coilOntology_term=ECO:0000255
TgeneSMC1Achr21:40568424chrX:53442118ENST000003222130251128_1163361234.0Compositional biasNote=Ala/Asp-rich (DA-box)
TgeneSMC1Achr21:40568424chrX:53442118ENST00000322213025515_629361234.0DomainNote=SMC hinge

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-151539_15480121.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-151687_16920121.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-15661_6680121.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-15821_8240121.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-1411539_154802270.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-1411687_169202270.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-141661_66802270.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-141821_82402270.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-151177_12470121.0DomainBromo 1
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-151330_14000121.0DomainBromo 2
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-1411177_124702270.0DomainBromo 1
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-1411330_140002270.0DomainBromo 2
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-15184_2230121.0RepeatNote=WD 1
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-15226_2650121.0RepeatNote=WD 2
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-15268_3110121.0RepeatNote=WD 3
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-15322_3650121.0RepeatNote=WD 4
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-15366_4050121.0RepeatNote=WD 5
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-15424_4630121.0RepeatNote=WD 6
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-15466_5060121.0RepeatNote=WD 7
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-15514_5530121.0RepeatNote=WD 8
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-141184_22302270.0RepeatNote=WD 1
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-141226_26502270.0RepeatNote=WD 2
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-141268_31102270.0RepeatNote=WD 3
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-141322_36502270.0RepeatNote=WD 4
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-141366_40502270.0RepeatNote=WD 5
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-141424_46302270.0RepeatNote=WD 6
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-141466_50602270.0RepeatNote=WD 7
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-141514_55302270.0RepeatNote=WD 8
TgeneSMC1Achr21:40568424chrX:53442118ENST0000032221302532_39361234.0Nucleotide bindingATP


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Fusion Gene Sequence for BRWD1-SMC1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10359_10359_1_BRWD1-SMC1A_BRWD1_chr21_40568424_ENST00000333229_SMC1A_chrX_53442118_ENST00000322213_length(transcript)=16446nt_BP=6899nt
AGGTCTTTGCCTCCGCGTCACTTTCTCCTCATCGAGTCCCCGGAGGCAGAGAGCTGAGCGAGGTTCGCCTCCCCGGGCGGGACACGAGCT
CCGGTCCTCTCTTGGCGCAAACCCCCGCCCCCCGCGGAGGGACTACTTTTCGTCTCCCGCGGAGGAACTACTTCCTCCCCCGCGGAGGCG
TCGGTCCAGGCGGCGCGCACGGTATGGCGGCGGCGGCGGCGGCGGCGGCGCGCGCCTGAGAAGAGGGGACGCCAGCCCGGTCAGGCCTCG
GCGCGGCCTACACGCTCCGCTCGCTCGCTCGCTCCCGCCTCCCGCCCCGCGCCCGGCCATGGCGGAGCCGTCGTCCGCCCGACGCCCGGT
GCCTCTCATCGAGTCGGAGCTGTACTTCCTTATCGCCCGGTACCTATCGGCGGGCCCGTGTCGGAGAGCGGCCCAGGTGCTGGTGCAGGA
GCTGGAGCAGTACCAGTTGTTGCCGAAGAGATTGGACTGGGAGGGCAACGAGCACAACAGGAGCTACGAGGAGTTGGTCTTGTCCAATAA
GCATGTGGCTCCTGATCATCTTTTGCAAATCTGCCAGCGCATCGGTCCTATGTTGGATAAAGAAATTCCACCCAGTATTTCAAGAGTCAC
TTCTTTACTTGGTGCAGGAAGGCAGTCTTTGCTACGTACAGCAAAAGACTGCAGGCACACAGTTTGGAAGGGCTCTGCCTTTGCTGCTCT
TCATAGAGGAAGACCTCCTGAAATGCCAGTGAATTATGGTTCCCCACCAAATCTTGTGGAGATACATCGAGGAAAACAACTCACAGGGTG
TTCCACTTTTAGTACAGCATTTCCAGGAACTATGTATCAGCATATAAAAATGCACAGAAGGATTCTCGGACATCTATCTGCTGTTTACTG
TGTAGCATTTGATAGGACAGGACATAGAATCTTTACAGGTTCAGATGACTGTTTGGTAAAGATTTGGTCAACACATAATGGCCGCTTGTT
ATCTACATTAAGAGGTCATTCTGCAGAAATTTCAGATATGGCAGTAAACTATGAGAATACAATGATTGCTGCGGGGAGCTGTGATAAAAT
TATTAGAGTGTGGTGCTTGAGAACTTGTGCCCCAGTTGCTGTGCTCCAAGGACACACAGGATCAATTACATCTTTACAGTTTAGCCCGAT
GGCCAAAGGCTCTCAAAGATACATGGTTTCCACTGGTGCTGATGGGACAGTTTGCTTTTGGCAATGGGATTTAGAATCCTTAAAATTTAG
CCCACGTCCCCTGAAGTTCACTGAAAAGCCTAGGCCAGGCGTTCAAATGCTTTGTTCTTCTTTTAGTGTTGGTGGTATGTTTTTAGCCAC
AGGTAGTACTGATCATGTAATCAGAATGTATTTTTTGGGTTTTGAAGCACCCGAAAAAATCGCAGAACTTGAAAGCCACACTGATAAAGT
AGATAGTATCCAATTTTGTAACAATGGTGATCGGTTCCTAAGTGGTAGCAGAGATGGAACAGCACGGATTTGGAGATTTGAGCAGTTAGA
ATGGAGGAGCATTTTATTGGATATGGCTACCAGAATCTCAGGGGACTTATCTTCCGAAGAGGAAAGGTTTATGAAACCTAAAGTAACAAT
GATAGCTTGGAATCAAAATGATAGCATTGTTGTCACAGCTGTGAATGATCATGTCCTCAAAGTGTGGAATTCTTACACTGGACAACTGCT
TCATAACTTAATGGGACATGCTGATGAAGTATTTGTTCTGGAGACACATCCCTTTGATTCCAGAATTATGTTATCTGCAGGACATGATGG
CAGCATATTTATATGGGATATTACAAAAGGTACCAAGATGAAACATTATTTTAATATGATTGAAGGACAAGGACATGGAGCTGTGTTTGA
CTGTAAGTTTTCACAGGATGGACAGCATTTTGCCTGTACAGATTCTCATGGGCACCTTCTGATATTTGGTTTTGGATGCAGCAAACCATA
TGAAAAGATTCCTGATCAGATGTTCTTCCATACTGACTATCGACCACTTATTAGAGATTCTAATAATTATGTCTTAGATGAGCAAACTCA
GCAGGCTCCTCATCTTATGCCTCCACCATTCTTGGTAGATGTAGATGGAAATCCTCATCCAACCAAGTATCAGAGATTAGTACCAGGCCG
AGAAAATTCTGCAGATGAACATTTGATTCCACAGCTGGGCTATGTGGCAACAAGTGATGGAGAGGTGATTGAACAAATTATAAGCCTGCA
AACCAATGATAATGATGAACGCAGCCCAGAATCGAGTATTCTTGATGGAATGATAAGACAGTTGCAGCAGCAGCAAGATCAGAGAATGGG
AGCAGATCAGGATACTATTCCAAGAGGACTTTCAAATGGTGAAGAAACACCCCGGAGAGGTTTTAGAAGGCTGAGCTTAGACATTCAGTC
CCCTCCAAATATTGGTCTGCGTCGTAGTGGACAAGTTGAAGGTGTTCGTCAGATGCATCAAAACGCTCCACGCAGTCAGATTGCTACAGA
ACGTGACCTGCAGGCTTGGAAACGAAGAGTGGTTGTACCAGAGGTACCACTAGGCATATTTAGGAAGCTGGAAGACTTCCGATTAGAGAA
AGGTGAAGAGGAAAGAAATCTTTATATAATAGGAAGAAAAAGAAAGACTCTTCAGCTCTCACATAAGTCGGATTCAGTGGTTTTGGTATC
ACAGTCTAGACAAAGGACATGTAGGCGTAAATATCCAAATTATGGTAGAAGAAATCGTAGCTGGCGTGAGTTATCTTCTGGAAATGAGTC
TTCAAGCTCTGTAAGACATGAGACTTCCTGTGATCAGAGTGAAGGTTCTGGTTCTTCAGAAGAGGATGAATGGAGAAGTGACAGAAAAAG
TGAGAGTTACAGCGAAAGTTCAAGTGACTCTTCATCTAGATATTCCGATTGGACAGCTGATGCGGGCATCAATTTGCAGCCTCCTTTAAG
AACATCATGTCGTCGACGAATTACTCGATTTTGTAGTAGTTCAGAAGATGAAATATCTACTGAGAATTTATCTCCTCCAAAAAGAAGACG
AAAGAGAAAGAAAGAAAATAAGCCTAAGAAGGAGAATTTGCGGAGGATGACTCCAGCAGAGCTTGCAAATATGGAGCATTTATATGAATT
TCACCCTCCAGTTTGGATTACTGACACCACACTTAGAAAATCTCCTTTTGTTCCTCAAATGGGTGATGAGGTAATATATTTTCGACAGGG
TCATGAAGCTTATATTGAGGCTGTAAGAAGAAATAATATTTATGAACTGAACCCTAATAAGGAGCCATGGAGAAAAATGGATCTTAGGGA
TCAAGAATTGGTTAAAATAGTTGGAATACGATATGAAGTTGGGCCCCCTACACTCTGTTGCCTAAAACTAGCATTTATAGATCCAGCAAC
TGGAAAACTTATGGACAAATCTTTCTCTATTAGATATCATGATATGCCAGATGTTATTGACTTTCTTGTATTGCGTCAATTTTATGATGA
AGCAAGACAGAGGAATTGGCAGTCTTGTGACAGATTCCGCTCTATTATTGATGATGCTTGGTGGTTTGGAACAGTGTTAAGTCAAGAGCC
ATATCAACCACAGTATCCTGATAGTCATTTCCAGTGTTATATTGTTAGGTGGGATAATACTGAAATTGAAAAACTTAGCCCATGGGACAT
GGAACCAATTCCTGATAATGTTGATCCACCTGAAGAATTAGGAGCTAGTATTTCTGTCACAACAGATGAGCTAGAGAAATTGCTCTATAA
ACCACAAGCTGGTGAATGGGGTCAGAAATCAAGAGATGAAGAATGTGATAGAATTATCAGTGGTATAGATCAACTTTTGAATCTTGATAT
AGCAGCAGCTTTTGCAGGCCCTGTTGATTTGTGTACATACCCGAAGTACTGTACTGTAGTAGCTTATCCAACCGATCTTTACACAATTCG
AATGAGACTTGTTAATCGATTTTACAGGAGGCTGTCTGCGTTAGTTTGGGAAGTCAGATATATAGAACATAATGCCAGAACATTTAACGA
ACCTGAGAGTGTAATTGCAAGATCAGCTAAAAAGATAACTGACCAACTTTTAAAATTTATCAAGAATCAACACTGTACAAATATCTCAGA
ACTTTCTAACACATCTGAAAATGATGAGCAAAATGCTGAGGATTTGGATGATAGTGATCTTCCTAAAACATCTTCTGGAAGGAGGAGAGT
CCATGATGGGAAAAAAAGCATCAGAGCTACGAACTATGTTGAAAGCAACTGGAAGAAACAGTGTAAGGAACTAGTGAACTTAATTTTTCA
GTGTGAAGATTCTGAACCATTTAGACAACCTGTTGATTTGGTTGAATATCCAGACTACAGAGATATTATAGATACCCCAATGGATTTTGG
AACAGTAAGGGAAACTCTAGATGCGGGAAATTATGACAGCCCTTTGGAGTTTTGCAAAGACATCCGGCTGATATTTAGCAATGCAAAAGC
GTATACACCAAACAAAAGATCAAAGATTTATAGTATGACCTTGAGATTATCTGCCTTATTTGAAGAAAAAATGAAGAAAATCTCTTCTGA
TTTTAAAATTGGTCAAAAATTCAATGAAAAACTTCGAAGAAGCCAGAGGTTCAAGCAACGGCAAAATTGTAAAGGTGACAGTCAGCCTAA
CAAAAGTATCAGAAACCTCAAGCCGAAGAGGTTAAAATCTCAGACAAAAATAATTCCTGAGTTGGTAGGTTCTCCTACCCAGTCTACCTC
AAGTAGGACAGCTTATCTTGGAACCCACAAGACAAGTGCTGGTATCTCTTCAGGTGTTACTTCTGGTGACTCTTCAGATTCAGCAGAATC
ATCAGAAAGGAGGAAAAGAAATAGACCTATAACAAATGGTTCTACATTATCTGAAAGTGAAGTGGAAGATTCTTTAGCTACCTCTTTGTC
ATCGTCAGCTTCCAGTAGTTCTGAGGAAAGCAAAGAGAGTTCCAGAGCTCGTGAATCCTCCTCACGCAGTGGGCTATCCAGAAGCAGCAA
TCTCAGGGTAACCAGAACTAGAGCTGCTCAAAGAAAAACTGGTCCCGTTTCATTAGCAAATGGATGTGGCAGAAAAGCCACTCGAAAGAG
AGTCTATTTAAGTGATTCTGATAACAATTCATTGGAGACTGGTGAAATTCTAAAAGCCAGAGCTGGAAATAACCGAAAAGTCTTAAGGAA
GTGTGCTGCTGTGGCTGCCAATAAAATAAAGCTAATGAGTGATGTAGAAGAGAATTCTAGCTCTGAAAGTGTCTGTTCTGGTCGGAAGCT
GCCTCACCGCAATGCTTCTGCTGTAGCTAGAAAAAAGTTATTACATAATTCTGAAGATGAACAGAGCTTAAAGTCAGAAATTGAAGAAGA
GGAGCTAAAAGATGAAAATCAACTATTACCAGTGTCCAGTTCTCACACTGCCCAGAGCAATGTTGATGAATCTGAAAACAGAGACTCAGA
GTCAGAAAGTGATTTGCGGGTAGCCCGGAAAAATTGGCATGCTAATGGTTACAAGTCCCATACTCCAGCACCTTCAAAGACAAAATTTCT
TAAAATAGAGTCTTCTGAGGAAGACTCTAAAAGTCATGATTCAGATCATGCATGTAACAGAACTGCTGGCCCATCAACGTCTGTGCAGAA
ACTTAAGGCAGAGAGCATCTCAGAGGAAGCAGATTCTGAACCAGGAAGATCTGGTGGTAGGAAATACAATACATTTCACAAGAATGCGAG
TTTCTTTAAAAAAACCAAGATTCTGAGTGACTCAGAAGACTCTGAATCTGAAGAGCAAGATAGAGAAGATGGGAAATGTCATAAAATGGA
AATGAACCCAATTTCAGGAAATCTGAACTGTGACCCTATTGCTATGTCCCAGTGTTCCTCAGATCATGGATGTGAAACTGATTTAGATTC
AGATGATGACAAAATAGAAAAACCAAACAATTTTATGAAAGATTCTGCATCACAAGACAATGGACTAAGCAGAAAAATTTCCAGGAAAAG
GGTCTGTTCCAGTGACTCAGACAGTAGTTTACAGGTGGTTAAGAAATCATCAAAAGCCAGAACAGGTCTCCTGAGGATTACTCGAAGATG
TGCAGCTACGGCTGCCAATAAGATCAAGCTCATGAGTGATGTAGAAGATGTCAGTTTAGAAAATGTGCACACTAGAAGCAAAAATGGAAG
GAAAAAACCTCTCCATCTTGCTTGTACTACAGCTAAGAAGAAATTGAGTGATTGTGAAGGAAGTGTACATTGTGAAGTACCAAGTGAACA
GTATGCCTGTGAAGGCAAGCCACCTGATCCTGACTCCGAAGGTAGTACAAAAGTGCTTAGTCAGGCTCTAAATGGAGACTCAGACTCTGA
AGATATGTTGAATTCAGAACACAAGCACAGGCATACCAATATTCACAAAATAGATGCACCTTCTAAAAGAAAAAGTTCCTCTGTTACATC
TTCAGGAGAAGATTCAAAAAGTCATATTCCAGGGAGTGAGACTGATAGGACATTTTCTTCAGAGTCAACCTTGGCACAAAAAGCTACTGC
AGAGAATAATTTTGAAGTGGAACTGAATTATGGGCTGCGCAGGTGGAATGGCAGAAGACTCAGGACCTATGGAAAGGCTCCTTTTAGTAA
GACAAAAGTGATTCATGATTCACAGGAAACAGCAGAGAAGGAAGTAAAAAGGAAGAGATCGCATCCTGAATTGGAAAATGTGAAAATCTC
TGAAACAACTGGGAATTCAAAGTTTAGACCTGATACTAGTTCCAAATCATCAGATTTGGGATCTGTAACTGAATCAGATATTGACTGTAC
TGATAATACAAAAACCAAAAGGAGGAAAACGAAAGGAAAAGCAAAAGTAGTTAGAAAAGGTAAGTCAAATCTCATGGATGCCATCAGCTT
TGTGCTAGGTGAAAAAACCAGCAACCTGCGGGTAAAGACCCTGCGGGACCTGATCCATGGAGCTCCTGTGGGCAAGCCAGCTGCCAACCG
GGCCTTTGTCAGCATGGTCTACTCTGAGGAGGGTGCTGAGGACCGTACCTTTGCCCGTGTCATTGTAGGAGGTTCTTCTGAGTACAAGAT
CAACAACAAAGTGGTCCAACTACATGAGTACAGTGAGGAATTAGAGAAGTTGGGCATTCTCATCAAAGCTCGTAACTTCCTCGTTTTCCA
GGGTGCTGTGGAATCTATTGCCATGAAGAACCCCAAAGAGAGGACAGCTCTATTTGAAGAGATTAGTCGTTCTGGGGAGCTGGCGCAGGA
GTATGACAAGCGAAAGAAGGAAATGGTGAAGGCTGAAGAGGACACACAGTTTAATTACCATCGCAAGAAAAATATTGCGGCTGAACGCAA
GGAAGCAAAGCAGGAGAAAGAAGAGGCTGACCGGTACCAGCGCCTGAAGGATGAGGTAGTACGGGCTCAGGTACAGCTGCAGCTCTTTAA
GCTTTACCATAATGAAGTGGAAATTGAGAAGCTCAACAAGGAACTGGCCTCAAAGAACAAGGAGATCGAGAAGGACAAGAAGCGTATGGA
CAAGGTGGAGGATGAACTGAAGGAGAAGAAGAAGGAGCTGGGCAAAATGATGCGGGAGCAGCAGCAGATTGAGAAGGAGATCAAGGAGAA
GGACTCAGAATTGAACCAGAAGCGGCCTCAGTACATCAAAGCCAAGGAGAACACCTCCCACAAAATCAAGAAGCTGGAAGCAGCCAAGAA
GTCTCTGCAGAATGCTCAGAAGCACTACAAGAAGCGTAAAGGTGACATGGATGAGCTGGAGAAGGAGATGCTGTCAGTGGAGAAGGCTCG
GCAGGAGTTTGAAGAACGGATGGAAGAAGAGAGTCAGAGTCAGGGCAGAGATTTGACGTTGGAGGAGAATCAGGTGAAGAAATACCACCG
GTTGAAAGAAGAAGCCAGCAAGAGAGCAGCTACCCTGGCCCAGGAGCTGGAGAAATTCAATCGAGACCAGAAAGCTGACCAGGACCGTCT
GGATCTGGAAGAACGGAAGAAAGTAGAGACAGAGGCCAAGATCAAGCAAAAGCTGCGGGAAATTGAAGAGAATCAGAAGCGGATTGAGAA
ACTGGAGGAATACATCACCACTAGCAAGCAGTCCCTAGAAGAGCAGAAGAAGCTAGAGGGGGAGCTGACAGAGGAGGTGGAGATGGCCAA
GCGGCGTATTGATGAAATCAATAAGGAGCTGAACCAGGTGATGGAGCAGCTAGGGGATGCCCGCATCGACCGCCAGGAGAGCAGCCGCCA
GCAGCGAAAGGCAGAGATAATGGAAAGCATCAAGCGCCTTTACCCTGGCTCTGTGTACGGCCGCCTCATTGACCTATGCCAGCCCACACA
AAAGAAGTATCAGATTGCTGTAACCAAGGTTTTGGGCAAGAACATGGATGCCATTATTGTGGACTCGGAGAAGACAGGCCGGGACTGTAT
TCAGTATATCAAGGAGCAGCGTGGGGAGCCTGAGACCTTCTTGCCTCTTGACTACCTGGAGGTGAAGCCTACAGATGAGAAACTCCGGGA
GCTGAAGGGGGCCAAGCTAGTGATTGATGTGATTCGCTATGAGCCACCTCATATCAAAAAGGCCCTGCAGTATGCTTGTGGCAATGCCCT
TGTCTGTGACAACGTGGAAGATGCCCGCCGCATTGCCTTTGGAGGCCACCAGCGCCACAAGACAGTGGCACTGGATGGAACCCTATTCCA
GAAGTCAGGAGTGATCTCTGGTGGGGCCAGTGACCTGAAGGCCAAGGCACGGCGCTGGGATGAGAAAGCAGTAGACAAGTTGAAAGAGAA
GAAGGAGCGCTTGACAGAGGAGCTGAAAGAGCAGATGAAGGCAAAACGGAAAGAGGCAGAGCTGCGTCAGGTGCAGTCTCAGGCCCATGG
ACTGCAGATGCGGCTCAAGTACTCCCAGAGTGACCTAGAACAGACCAAGACACGACATCTAGCCCTGAATCTGCAGGAAAAATCCAAGCT
GGAGAGTGAGCTAGCCAACTTTGGGCCTCGCATTAATGATATCAAGAGGATCATTCAGAGCCGAGAGAGGGAAATGAAAGACTTGAAGGA
GAAGATGAACCAGGTAGAGGATGAGGTGTTTGAAGAGTTTTGTCGGGAGATTGGTGTGCGCAACATCCGGGAGTTTGAGGAAGAAAAGGT
GAAACGGCAGAATGAAATCGCCAAGAAGCGTTTGGAGTTTGAGAATCAGAAGACTCGCTTGGGCATTCAGTTGGATTTTGAAAAGAACCA
ACTGAAGGAGGACCAAGATAAAGTACACATGTGGGAGCAGACAGTGAAAAAAGATGAAAATGAGATAGAAAAGCTCAAAAAGGAGGAACA
AAGACACATGAAGATCATAGATGAGACCATGGCTCAGCTACAAGACCTGAAGAATCAGCATCTGGCCAAGAAGTCGGAAGTGAATGACAA
GAATCATGAGATGGAGGAGATTCGTAAGAAACTCGGGGGCGCCAACAAGGAAATGACCCATTTACAGAAGGAGGTGACAGCCATTGAGAC
CAAGCTTGAACAGAAGCGCAGTGACCGTCACAACTTGCTACAGGCCTGTAAGATGCAGGACATTAAGTTGCCACTGTCAAAAGGCACCAT
GGATGATATTAGTCAGGAAGAGGGTAGCTCCCAGGGGGAGGACTCAGTGAGTGGTTCACAGAGAATTTCCAGTATCTATGCACGAGAGGC
CCTCATTGAGATTGACTACGGTGATCTGTGTGAGGATCTGAAGGATGCCCAGGCTGAGGAAGAGATCAAGCAAGAGATGAACACACTGCA
GCAGAAGCTGAATGAGCAGCAGAGTGTGCTTCAGCGTATTGCCGCCCCCAACATGAAGGCCATGGAAAAGCTGGAAAGTGTCCGAGACAA
GTTCCAGGAGACCTCAGATGAGTTTGAAGCAGCCCGAAAGCGAGCAAAGAAGGCCAAGCAGGCATTCGAACAGATCAAGAAGGAGCGCTT
TGACCGCTTCAATGCTTGTTTTGAATCTGTGGCTACCAACATTGATGAGATCTATAAGGCCCTGTCCCGCAATAGCAGTGCCCAGGCATT
CCTGGGCCCTGAGAACCCTGAAGAGCCCTACTTGGATGGCATCAACTACAACTGTGTGGCTCCTGGGAAACGCTTCCGGCCTATGGACAA
CTTGTCAGGCGGGGAGAAGACAGTGGCAGCTCTGGCCCTGCTCTTTGCCATCCACAGCTACAAGCCAGCCCCCTTCTTCGTCCTGGATGA
GATTGATGCTGCCTTGGATAACACCAACATTGGCAAGGTGGCAAATTACATCAAGGAGCAGTCGACTTGCAACTTCCAGGCCATCGTCAT
CTCTCTCAAGGAGGAGTTCTACACCAAGGCCGAGAGCCTCATTGGAGTCTATCCTGAGCAAGGGGACTGTGTGATCAGCAAAGTCCTGAC
CTTCGACCTCACCAAGTACCCAGATGCCAACCCCAACCCCAATGAGCAGTAGCAGTATTTTTGCCCTCCCGCCCTGTCTGGATCCCTAAG
CTGTCCCTCTCCCAATCTCTGGATATTTGACTCCCAACCTTCCCCCTACCTCCTGGCCCTTTTTGGTGTAGTCATGGGATTTAGGCACTG
CTAATCAAGCATGAAGAGGAACAGAGGTGATGTTAGGTCTGGAGCAAAAATTCCTGAACGACAGGGAGTATTCTGGCCTCTGAAAGGAGG
TGCTGAGCTGAACAGGGCCATCTGTTCATCACACACACCCCCTTCCTCCCCCTCATCACCCATAATCGTGGGCCCCTTGGGCCTCTTGCC
CACTGTGTGTGTGGGTATGTATGTGTGTATGTATGTATCCGCATGTGTGCATGTGAGTATGTTTGCAAAATAATAAAGGATATTGGAGAC
CTGTTTTAGAAGGAGCCTAGGCTGAATTTGATTCCAAGAGAGCTTAGGATGACAGCACCCCTGAGCTGGGCAAAGGTACTCAGGACCTCA
TAGGAGTCTTAGGCAGTTACCTGAAACTGCCTTCATTCACTCATTTGTGTATTCATTCATTTATGTATTCATCAGACACATACCGAACAC
CCTCTATTTGTCAGGCTCTGTGCTTGGAATACAGAGTTGAATCAGACATGATCTCTACCCTCCTAGTAAGGAGATACAGTGGGTTCATGA
ATGACTATAGTTAGCTGAATGTCATATGTACTTTGAATTTGAGAAGTGGGTGATCCCCTCTAGGCTTCCTGGAGGTCACATTTAAGCTAG
ACCTTGACAAATTGGTAGGATTTGGTCAGGCACTAGGAGTGGAGCATGAGCTCTGGGGACAGACAGTTATGGGTTCTGGTCCCACTTTTT
ATCACTTACTAGTTGTTTGACCTTGGGCAAGTCATTTGACCTTCTGTGCCTCAGTTTCCTCATCTGTAAAATGGGGCTAACAATATTACC
TACCTCATAGGATTTAATGATGTCAAGCTCCTCACTGGAGGCCTTATCCCTTCGTGGAGCCCACTAGGTGCCGACCCCTCAGAATATAAC
CCTCATGCCTGGACCCCTGAGAGCTTCTGATCCCAGCTATTAGGGACAGAAGAAGCCTCCAAATCTGGAAGGTGCTGAATGCCCTGCTGA
CTGGGAAAGTTTCAGGGCACTGATGGGGTCTACCTGGTAAGCGGAGGGCCTGAGGAAACCTGTAGCTTCAATCATGTCTGGTAACCGGGT
GCCTGAGCCCCAATCTGGGTTGTGAGGAAATAGGGGAGAGGTATCCTGGGCCACATCCCAGCCTAACACCTGTGAGGTTCATTTTAGGAA
CTAACCTCATTAGCTATAAGGATCATGCAGAGGCAGCAAAGCCGGGTGCGATGAGCTCAGCCTTTACTCATTCACATACACCATCACACT
TTAATTCCAATCTGTATATTGCTTTTTAAAAGTTAAGTCCATTCTAATTACCCAAATATGCATGAATTCATTCTCCTTTTGAGAAGTTAG
ATTGTTAAAGATAGTCTCATTCAGCTACCAACCACTCCTTGATCCTTCCCTTCTTAGTGGCTGTTGTTTGTTGTACTTCCGTTTAGACTT
TGTTTTAATGCTTGTACGTACATATGTGAACTCATTGGAAATATTGTGTGTTTAATGCAAATGATATATTGAATTGTTTAGCAATTTGTT
TTCTTTGCTTAACGATGTTTTTGAGATCTGTGCATGTTACTTAATGTAGCTCAATCCATCTTCTGTAATTGCTGTATAGATTGTCATCAT
ATGATTACCACATTTTACTTACGCATTTCTTTTGTGATGGACATTAAGACTGTTTTTAGGTTTTGCTATTACAAAATACTACACAGGAGC
ATCACTATGCCTGTGTGAAAGTATATGTATGAAAGTTTACCTAGGGTTGATTCCTAGAAGTGGAATTGCAAAGTCATAGGATATTTATAT
ATTGGTTTTTAATAATACTTCCAAATTGCCCTCCTGTACTATTTACTCAGTATTTTTCTTGAGGTTGATCTGAGGTCTAACATTGTTATC
CTATATCATTTTCATCCCAAGTAGTGATATCTGTGAAATCACAGGTTTGATGTGTGCTAATTATGTATTCTTCTAATACATATTAAAAGA
CATAACTATCAAAACAAAATAAATTTGTCTGTTTTCAACCAAAGAAGTCACGTACCACTGGTGGTACTGTGTGCCATAATTTGGCAAATG
CTGGCCTTTATGGACGAGCACAATTCGGGGGTCAGACCTGGTTCAAATTCTAGCTGTAGAAACTTGTGCAAGTTACTTCACCTCTGAGCC
TAAGTTTCCACATCTGTAAAAGGAGATAATAAACACCTACCTTGCAGTAGTGAAGCAAAGAGAAAATTAAATATATATGAAGCAATTTGG
CTGGCATCTAGATCATTCACAGCCCTTTAAAGGTCACCTTTGCTGTTCTCCCCACTTTACAGATAAGGAAACTGAGGCCCAAAAAGGTTT
GAACCCAGGTCTTCCAAGTCATTCAAGTGCTTTCTCCACTGTACAGGTGGTTATCAACCTTGGCTGCGCATCAGAATCGTTTGTAAAGCT
TTTTCTTTTTCCTTTTTAAAAAGTAAAGCAATATATACACAGGTAAAAAAATAAAATAGTACAGAAGGGCTTATAATGAGAAGCAGCAGT
TCCCTGCTTGCACCCCCACATCCAAAGGATGTGGAGCTCTTTAAAAATAAATTGCTCTGGTCCCACCTCTGGAAATCTGATTCAGCCAGC
ATGGATAATAACCCAGATAACTAACCCCTACCTCACAGGATAAAAAGGATTACATGAGATGCCTTAGGCTAAGGCCCTGGCACACAGGAA
CACATGTGCTACAAAGGAGCTTTGGGGACTTAAGTCCTGAGGATCCAGGAGGTGAGGTGACTTGTCCAAGATTCCACTGGTTTAGTGGCA
GAGCCTAGACTTCCACTCGGATCTATTTAGTGCTTGCCCCCTGCTCTCTCCTGTCGTGCCCCACCACCTCCTGGCATCACAGGGCAACCG
TTGTCAAGGCTATGCTCACGGGAGGCTGGGCACCACAGTGTTTCCAAGAGCAAGCTGGATCCGAGTAGATTCCCTAGGGCTTGTTGGAGG
AACTAGTTTGACTCCCTTATACTGTGGACGCAGTAGCCTTGCTGTAGGGAGTTGAAGAGTACTCCACAACAGTATCTTAAGTTTAACTGG
GCACTTCCCTCTGGAAATCACAGTGTTGTGCACCAGGAACACAAAGATGAGTCAAATCTTTATCCTGCCTTTGAGGAGCTCACTGTTTAG
TTGGGGAAACCATTTGTAAAACAGCCATTAACCATACAGTGTGATCAACACTGACAGGAGCACAGGAAAAACATCTAGCTTATGTGAAGA
TTCAGAGAAGGCATCCTGTAGTCTAGGTGGTGATACCTGAACTGAGTCTTGAGGGACGGGTAGGAATTAGCCAGTTGAGGAAGTAGAAGG
AATTTCCAGATATTGGAAACAGTATGCATGAAGACATGAAGGCAAGAAACAGCAAAACAAATACTGAAGCATGAAGATTCCTGGGGTGGG
GGGAAAGCAGCAAGAAAAGGTAGAGAGGAACCAGATTGGAAGAGGGTCGTAAATGCATGGCTACAGAATTCAGATTTGTTTTGTAGGACA
GTGTGGTTCCCAAACTGGCTGTATACCACAAACAGGTACGGCATTCTGGGCCCCGGCCCCTAAAACATTCATTAAGTCTGGGGTGAAGAT
TTGGAATCTTGAATGCTTATAAAGGTTACCACATGACTAGGGTACAGCCAGATTTGGAAACCATAGCTTGAAGGCAGTGAGGGAGCCATG
AAATGGTTTTTAATAGGGGGACTCCAGATCAGATGTGAACTTAACCTGTTTCTGGCTGGCTAGCCAACCAGCATGGAAAACAGATTAGGT
TAGATGTTCATGCTGTATGTGCCCGTGCCTGTAGCTTCCCTGTTAATCAGCTTCTTACACTACTATATTTGCTTATTTTGTCTCTGAATA
AGCTTTAGGCACCACAAGGGTGGGCCTGGGGATATTTTGCTTACCAGTATAGCCCCTGCAAAAAAGCACAGTGCCTGACACAAAACAGGC
ACCCAGTAAAGTTTTTGAATGAATGAATGCATGAGTGAATCCATTTGTGAGAGAGCGAATGGAGATGACAAGATTAGCTAGGAGACTGGA
AAAAGACCAGGAGGCCTGCACTAGGGCAAAGGCCAGTAGGAATAGATTGGAGGTGTTAAGGTGTGAACTGTTAAGGTAAGATGATAACTT
AATGACTGATTATTGGATGTGGAGGGTGACTGAGAGGATAGAATGAGTACCCATGAATAGCCATGATTCCTACCCTGTCCCAGTCATCTC
TTTCCTTATCCATCTCTGAAACAATCTGCTTACATCCTCCTCAGCAACTGGAATTCCTCAAGTTAGTTAGACATTCTGTGTGCTGTGTGG
TCTCTCACTGCCCCCCCACTCCCCACCCCTCCACAAGCCATTGATTCATTCATCCAGTTCAATAAATCTTGGCTAAGCACCTCCAGTGTG
CAGTAAGGCTCTTCCAAGCCAGGACTCTGACTCCCTCTTTCCTACCTCAAGAGATGTTTTTGAGGGCTTTCCCAGGTAAGAGTCACATCT
CTTATACAATAACTTATAGTGAGATACCCAGAATGTCAGACTTGTAAGGGAAGACTGCCCAAACCCCTTCTGAGGTCCTCAGAGGGGAAT
TAACTTCCTAAGGTCCGACTGCTAGGAAGTGTTGGAGCCAGAAATGGAACCTAGGTTTCCTTTCTATGTCATCTCTGGAGTCTTGATCTT
GATCTATCCCATTGTAGATCAGGACAGGCAGAGGTGGTCAGGGAGAAGGTGGGACTTAGGTTGAACCTTGAAGGTCAATGTATTGGACAG
GTCAAACAAGATGGTTGCCAATTACACTGCCCCCTTCTGGAAACCCTTAGCAAACCTGCCATGCTTGCAGTCCCTTCTAAGGGGTTTCCT
TAGCATAAGTTGCCATGCTCTGTACCATGTGACCTCACAATCCTGGCCACAGATAGCTAGATGTGGATAGTGTCTGGTTCAAGGGCAACC
AATCTCTAGGCTGGCCAGTGGCCTGTTAGCTGGACTGGCATAAGGACTTCACCTTACAGGGGTGGCATGTATCAAATGGCAAATGTATGA
AACAACCAGATCTTTCAGGGAGGCAGAATGTGAGCTATTCAGAAGAAGTGAACGTTAATTAGAATTTAATGAGGCATTAGTGGTGGTGGA
TGAGGGGTGGCCAGAAACTAAACAGCAAAAGCAAAGAGAAAGCTGCAGAAACCATAAGTAAGCAGAGGTCATGAGACATTTGTATAATGA
GATCACGGAGCCACAGGGTGGCAGAAGCCATGAAGCAGCAAGGCAACAATGGGCTAGAAGCCATGAAGCAATAGGAGCCACGAGGAACAG
AAACCGTGAGACAAAACTGACTATGAGATCCACAAAGCAGCAGAAGGCTTGAATAGATAAGATCATGAGACAGTAGAAGCGATGAGACTG
CAAGAACCACAAGGTAGCCAGAACCATGTGGCAACATGGCAACAGGAATGGAAGAGGCAGCAGGAGCTACAATGCAGAAAAGCCATGGAT
TAATAGGAACTGAAGCGCCGGGAGCCATGAAGCTGCAGGACCCATGAGGCAGAAAAAGCCATGGGCTAGCATCGAGGGGGGCAGAAAGAA
GTTAGTCAGTAGCAGTAGGAGGAGTATAAATACAGCCAGAAAGGAGTTGAGTCACCAATTTGGGAAGCACTAGAGAAGGGAGCAACAGAT
GCCTGCAGCTGAGGGGGTGACAAGATAAGCCAGGCTCTAGAGCTGCTTTGGATCATGAACCATTTTCAAGTTTCTGTTCTTCCATGAGGC

>10359_10359_1_BRWD1-SMC1A_BRWD1_chr21_40568424_ENST00000333229_SMC1A_chrX_53442118_ENST00000322213_length(amino acids)=3418AA_BP=2221
MRRGDASPVRPRRGLHAPLARSLPPPAPRPAMAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEH
NRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNL
VEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYE
NTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLC
SSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSS
EEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFN
MIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNP
HPTKYQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIRQLQQQQDQRMGADQDTIPRGLSNGEETPR
RGFRRLSLDIQSPPNIGLRRSGQVEGVRQMHQNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQ
LSHKSDSVVLVSQSRQRTCRRKYPNYGRRNRSWRELSSGNESSSSVRHETSCDQSEGSGSSEEDEWRSDRKSESYSESSSDSSSRYSDWT
ADAGINLQPPLRTSCRRRITRFCSSSEDEISTENLSPPKRRRKRKKENKPKKENLRRMTPAELANMEHLYEFHPPVWITDTTLRKSPFVP
QMGDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIVGIRYEVGPPTLCCLKLAFIDPATGKLMDKSFSIRYHDMPDV
IDFLVLRQFYDEARQRNWQSCDRFRSIIDDAWWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASIS
VTTDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTVVAYPTDLYTIRMRLVNRFYRRLSALVWEV
RYIEHNARTFNEPESVIARSAKKITDQLLKFIKNQHCTNISELSNTSENDEQNAEDLDDSDLPKTSSGRRRVHDGKKSIRATNYVESNWK
KQCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLDAGNYDSPLEFCKDIRLIFSNAKAYTPNKRSKIYSMTLRLSA
LFEEKMKKISSDFKIGQKFNEKLRRSQRFKQRQNCKGDSQPNKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSRTAYLGTHKTSAGISSG
VTSGDSSDSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARESSSRSGLSRSSNLRVTRTRAAQRKTGPVSL
ANGCGRKATRKRVYLSDSDNNSLETGEILKARAGNNRKVLRKCAAVAANKIKLMSDVEENSSSESVCSGRKLPHRNASAVARKKLLHNSE
DEQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESESDLRVARKNWHANGYKSHTPAPSKTKFLKIESSEEDSKSHDSDHAC
NRTAGPSTSVQKLKAESISEEADSEPGRSGGRKYNTFHKNASFFKKTKILSDSEDSESEEQDREDGKCHKMEMNPISGNLNCDPIAMSQC
SSDHGCETDLDSDDDKIEKPNNFMKDSASQDNGLSRKISRKRVCSSDSDSSLQVVKKSSKARTGLLRITRRCAATAANKIKLMSDVEDVS
LENVHTRSKNGRKKPLHLACTTAKKKLSDCEGSVHCEVPSEQYACEGKPPDPDSEGSTKVLSQALNGDSDSEDMLNSEHKHRHTNIHKID
APSKRKSSSVTSSGEDSKSHIPGSETDRTFSSESTLAQKATAENNFEVELNYGLRRWNGRRLRTYGKAPFSKTKVIHDSQETAEKEVKRK
RSHPELENVKISETTGNSKFRPDTSSKSSDLGSVTESDIDCTDNTKTKRRKTKGKAKVVRKGKSNLMDAISFVLGEKTSNLRVKTLRDLI
HGAPVGKPAANRAFVSMVYSEEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALF
EEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASK
NKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDE
LEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKL
REIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSV
YGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHI
KKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKE
AELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIG
VRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKN
QHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSG
SQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKA
KQAFEQIKKERFDRFNACFESVATNIDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALALLFAIH

--------------------------------------------------------------
>10359_10359_2_BRWD1-SMC1A_BRWD1_chr21_40568424_ENST00000380800_SMC1A_chrX_53442118_ENST00000322213_length(transcript)=16217nt_BP=6670nt
GCGCGCCTGAGAAGAGGGGACGCCAGCCCGGTCAGGCCTCGGCGCGGCCTACACGCTCCGCTCGCTCGCTCGCTCCCGCCTCCCGCCCCG
CGCCCGGCCATGGCGGAGCCGTCGTCCGCCCGACGCCCGGTGCCTCTCATCGAGTCGGAGCTGTACTTCCTTATCGCCCGGTACCTATCG
GCGGGCCCGTGTCGGAGAGCGGCCCAGGTGCTGGTGCAGGAGCTGGAGCAGTACCAGTTGTTGCCGAAGAGATTGGACTGGGAGGGCAAC
GAGCACAACAGGAGCTACGAGGAGTTGGTCTTGTCCAATAAGCATGTGGCTCCTGATCATCTTTTGCAAATCTGCCAGCGCATCGGTCCT
ATGTTGGATAAAGAAATTCCACCCAGTATTTCAAGAGTCACTTCTTTACTTGGTGCAGGAAGGCAGTCTTTGCTACGTACAGCAAAAGAC
TGCAGGCACACAGTTTGGAAGGGCTCTGCCTTTGCTGCTCTTCATAGAGGAAGACCTCCTGAAATGCCAGTGAATTATGGTTCCCCACCA
AATCTTGTGGAGATACATCGAGGAAAACAACTCACAGGGTGTTCCACTTTTAGTACAGCATTTCCAGGAACTATGTATCAGCATATAAAA
ATGCACAGAAGGATTCTCGGACATCTATCTGCTGTTTACTGTGTAGCATTTGATAGGACAGGACATAGAATCTTTACAGGTTCAGATGAC
TGTTTGGTAAAGATTTGGTCAACACATAATGGCCGCTTGTTATCTACATTAAGAGGTCATTCTGCAGAAATTTCAGATATGGCAGTAAAC
TATGAGAATACAATGATTGCTGCGGGGAGCTGTGATAAAATTATTAGAGTGTGGTGCTTGAGAACTTGTGCCCCAGTTGCTGTGCTCCAA
GGACACACAGGATCAATTACATCTTTACAGTTTAGCCCGATGGCCAAAGGCTCTCAAAGATACATGGTTTCCACTGGTGCTGATGGGACA
GTTTGCTTTTGGCAATGGGATTTAGAATCCTTAAAATTTAGCCCACGTCCCCTGAAGTTCACTGAAAAGCCTAGGCCAGGCGTTCAAATG
CTTTGTTCTTCTTTTAGTGTTGGTGGTATGTTTTTAGCCACAGGTAGTACTGATCATGTAATCAGAATGTATTTTTTGGGTTTTGAAGCA
CCCGAAAAAATCGCAGAACTTGAAAGCCACACTGATAAAGTAGATAGTATCCAATTTTGTAACAATGGTGATCGGTTCCTAAGTGGTAGC
AGAGATGGAACAGCACGGATTTGGAGATTTGAGCAGTTAGAATGGAGGAGCATTTTATTGGATATGGCTACCAGAATCTCAGGGGACTTA
TCTTCCGAAGAGGAAAGGTTTATGAAACCTAAAGTAACAATGATAGCTTGGAATCAAAATGATAGCATTGTTGTCACAGCTGTGAATGAT
CATGTCCTCAAAGTGTGGAATTCTTACACTGGACAACTGCTTCATAACTTAATGGGACATGCTGATGAAGTATTTGTTCTGGAGACACAT
CCCTTTGATTCCAGAATTATGTTATCTGCAGGACATGATGGCAGCATATTTATATGGGATATTACAAAAGGTACCAAGATGAAACATTAT
TTTAATATGATTGAAGGACAAGGACATGGAGCTGTGTTTGACTGTAAGTTTTCACAGGATGGACAGCATTTTGCCTGTACAGATTCTCAT
GGGCACCTTCTGATATTTGGTTTTGGATGCAGCAAACCATATGAAAAGATTCCTGATCAGATGTTCTTCCATACTGACTATCGACCACTT
ATTAGAGATTCTAATAATTATGTCTTAGATGAGCAAACTCAGCAGGCTCCTCATCTTATGCCTCCACCATTCTTGGTAGATGTAGATGGA
AATCCTCATCCAACCAAGTATCAGAGATTAGTACCAGGCCGAGAAAATTCTGCAGATGAACATTTGATTCCACAGCTGGGCTATGTGGCA
ACAAGTGATGGAGAGGTGATTGAACAAATTATAAGCCTGCAAACCAATGATAATGATGAACGCAGCCCAGAATCGAGTATTCTTGATGGA
ATGATAAGACAGTTGCAGCAGCAGCAAGATCAGAGAATGGGAGCAGATCAGGATACTATTCCAAGAGGACTTTCAAATGGTGAAGAAACA
CCCCGGAGAGGTTTTAGAAGGCTGAGCTTAGACATTCAGTCCCCTCCAAATATTGGTCTGCGTCGTAGTGGACAAGTTGAAGGTGTTCGT
CAGATGCATCAAAACGCTCCACGCAGTCAGATTGCTACAGAACGTGACCTGCAGGCTTGGAAACGAAGAGTGGTTGTACCAGAGGTACCA
CTAGGCATATTTAGGAAGCTGGAAGACTTCCGATTAGAGAAAGGTGAAGAGGAAAGAAATCTTTATATAATAGGAAGAAAAAGAAAGACT
CTTCAGCTCTCACATAAGTCGGATTCAGTGGTTTTGGTATCACAGTCTAGACAAAGGACATGTAGGCGTAAATATCCAAATTATGGTAGA
AGAAATCGTAGCTGGCGTGAGTTATCTTCTGGAAATGAGTCTTCAAGCTCTGTAAGACATGAGACTTCCTGTGATCAGAGTGAAGGTTCT
GGTTCTTCAGAAGAGGATGAATGGAGAAGTGACAGAAAAAGTGAGAGTTACAGCGAAAGTTCAAGTGACTCTTCATCTAGATATTCCGAT
TGGACAGCTGATGCGGGCATCAATTTGCAGCCTCCTTTAAGAACATCATGTCGTCGACGAATTACTCGATTTTGTAGTAGTTCAGAAGAT
GAAATATCTACTGAGAATTTATCTCCTCCAAAAAGAAGACGAAAGAGAAAGAAAGAAAATAAGCCTAAGAAGGAGAATTTGCGGAGGATG
ACTCCAGCAGAGCTTGCAAATATGGAGCATTTATATGAATTTCACCCTCCAGTTTGGATTACTGACACCACACTTAGAAAATCTCCTTTT
GTTCCTCAAATGGGTGATGAGGTAATATATTTTCGACAGGGTCATGAAGCTTATATTGAGGCTGTAAGAAGAAATAATATTTATGAACTG
AACCCTAATAAGGAGCCATGGAGAAAAATGGATCTTAGGGATCAAGAATTGGTTAAAATAGTTGGAATACGATATGAAGTTGGGCCCCCT
ACACTCTGTTGCCTAAAACTAGCATTTATAGATCCAGCAACTGGAAAACTTATGGACAAATCTTTCTCTATTAGATATCATGATATGCCA
GATGTTATTGACTTTCTTGTATTGCGTCAATTTTATGATGAAGCAAGACAGAGGAATTGGCAGTCTTGTGACAGATTCCGCTCTATTATT
GATGATGCTTGGTGGTTTGGAACAGTGTTAAGTCAAGAGCCATATCAACCACAGTATCCTGATAGTCATTTCCAGTGTTATATTGTTAGG
TGGGATAATACTGAAATTGAAAAACTTAGCCCATGGGACATGGAACCAATTCCTGATAATGTTGATCCACCTGAAGAATTAGGAGCTAGT
ATTTCTGTCACAACAGATGAGCTAGAGAAATTGCTCTATAAACCACAAGCTGGTGAATGGGGTCAGAAATCAAGAGATGAAGAATGTGAT
AGAATTATCAGTGGTATAGATCAACTTTTGAATCTTGATATAGCAGCAGCTTTTGCAGGCCCTGTTGATTTGTGTACATACCCGAAGTAC
TGTACTGTAGTAGCTTATCCAACCGATCTTTACACAATTCGAATGAGACTTGTTAATCGATTTTACAGGAGGCTGTCTGCGTTAGTTTGG
GAAGTCAGATATATAGAACATAATGCCAGAACATTTAACGAACCTGAGAGTGTAATTGCAAGATCAGCTAAAAAGATAACTGACCAACTT
TTAAAATTTATCAAGAATCAACACTGTACAAATATCTCAGAACTTTCTAACACATCTGAAAATGATGAGCAAAATGCTGAGGATTTGGAT
GATAGTGATCTTCCTAAAACATCTTCTGGAAGGAGGAGAGTCCATGATGGGAAAAAAAGCATCAGAGCTACGAACTATGTTGAAAGCAAC
TGGAAGAAACAGTGTAAGGAACTAGTGAACTTAATTTTTCAGTGTGAAGATTCTGAACCATTTAGACAACCTGTTGATTTGGTTGAATAT
CCAGACTACAGAGATATTATAGATACCCCAATGGATTTTGGAACAGTAAGGGAAACTCTAGATGCGGGAAATTATGACAGCCCTTTGGAG
TTTTGCAAAGACATCCGGCTGATATTTAGCAATGCAAAAGCGTATACACCAAACAAAAGATCAAAGATTTATAGTATGACCTTGAGATTA
TCTGCCTTATTTGAAGAAAAAATGAAGAAAATCTCTTCTGATTTTAAAATTGGTCAAAAATTCAATGAAAAACTTCGAAGAAGCCAGAGG
TTCAAGCAACGGCAAAATTGTAAAGGTGACAGTCAGCCTAACAAAAGTATCAGAAACCTCAAGCCGAAGAGGTTAAAATCTCAGACAAAA
ATAATTCCTGAGTTGGTAGGTTCTCCTACCCAGTCTACCTCAAGTAGGACAGCTTATCTTGGAACCCACAAGACAAGTGCTGGTATCTCT
TCAGGTGTTACTTCTGGTGACTCTTCAGATTCAGCAGAATCATCAGAAAGGAGGAAAAGAAATAGACCTATAACAAATGGTTCTACATTA
TCTGAAAGTGAAGTGGAAGATTCTTTAGCTACCTCTTTGTCATCGTCAGCTTCCAGTAGTTCTGAGGAAAGCAAAGAGAGTTCCAGAGCT
CGTGAATCCTCCTCACGCAGTGGGCTATCCAGAAGCAGCAATCTCAGGGTAACCAGAACTAGAGCTGCTCAAAGAAAAACTGGTCCCGTT
TCATTAGCAAATGGATGTGGCAGAAAAGCCACTCGAAAGAGAGTCTATTTAAGTGATTCTGATAACAATTCATTGGAGACTGGTGAAATT
CTAAAAGCCAGAGCTGGAAATAACCGAAAAGTCTTAAGGAAGTGTGCTGCTGTGGCTGCCAATAAAATAAAGCTAATGAGTGATGTAGAA
GAGAATTCTAGCTCTGAAAGTGTCTGTTCTGGTCGGAAGCTGCCTCACCGCAATGCTTCTGCTGTAGCTAGAAAAAAGTTATTACATAAT
TCTGAAGATGAACAGAGCTTAAAGTCAGAAATTGAAGAAGAGGAGCTAAAAGATGAAAATCAACTATTACCAGTGTCCAGTTCTCACACT
GCCCAGAGCAATGTTGATGAATCTGAAAACAGAGACTCAGAGTCAGAAAGTGATTTGCGGGTAGCCCGGAAAAATTGGCATGCTAATGGT
TACAAGTCCCATACTCCAGCACCTTCAAAGACAAAATTTCTTAAAATAGAGTCTTCTGAGGAAGACTCTAAAAGTCATGATTCAGATCAT
GCATGTAACAGAACTGCTGGCCCATCAACGTCTGTGCAGAAACTTAAGGCAGAGAGCATCTCAGAGGAAGCAGATTCTGAACCAGGAAGA
TCTGGTGGTAGGAAATACAATACATTTCACAAGAATGCGAGTTTCTTTAAAAAAACCAAGATTCTGAGTGACTCAGAAGACTCTGAATCT
GAAGAGCAAGATAGAGAAGATGGGAAATGTCATAAAATGGAAATGAACCCAATTTCAGGAAATCTGAACTGTGACCCTATTGCTATGTCC
CAGTGTTCCTCAGATCATGGATGTGAAACTGATTTAGATTCAGATGATGACAAAATAGAAAAACCAAACAATTTTATGAAAGATTCTGCA
TCACAAGACAATGGACTAAGCAGAAAAATTTCCAGGAAAAGGGTCTGTTCCAGTGACTCAGACAGTAGTTTACAGGTGGTTAAGAAATCA
TCAAAAGCCAGAACAGGTCTCCTGAGGATTACTCGAAGATGTGCAGCTACGGCTGCCAATAAGATCAAGCTCATGAGTGATGTAGAAGAT
GTCAGTTTAGAAAATGTGCACACTAGAAGCAAAAATGGAAGGAAAAAACCTCTCCATCTTGCTTGTACTACAGCTAAGAAGAAATTGAGT
GATTGTGAAGGAAGTGTACATTGTGAAGTACCAAGTGAACAGTATGCCTGTGAAGGCAAGCCACCTGATCCTGACTCCGAAGGTAGTACA
AAAGTGCTTAGTCAGGCTCTAAATGGAGACTCAGACTCTGAAGATATGTTGAATTCAGAACACAAGCACAGGCATACCAATATTCACAAA
ATAGATGCACCTTCTAAAAGAAAAAGTTCCTCTGTTACATCTTCAGGAGAAGATTCAAAAAGTCATATTCCAGGGAGTGAGACTGATAGG
ACATTTTCTTCAGAGTCAACCTTGGCACAAAAAGCTACTGCAGAGAATAATTTTGAAGTGGAACTGAATTATGGGCTGCGCAGGTGGAAT
GGCAGAAGACTCAGGACCTATGGAAAGGCTCCTTTTAGTAAGACAAAAGTGATTCATGATTCACAGGAAACAGCAGAGAAGGAAGTAAAA
AGGAAGAGATCGCATCCTGAATTGGAAAATGTGAAAATCTCTGAAACAACTGGGAATTCAAAGTTTAGACCTGATACTAGTTCCAAATCA
TCAGATTTGGGATCTGTAACTGAATCAGATATTGACTGTACTGATAATACAAAAACCAAAAGGAGGAAAACGAAAGGAAAAGCAAAAGTA
GTTAGAAAAGGTAAGTCAAATCTCATGGATGCCATCAGCTTTGTGCTAGGTGAAAAAACCAGCAACCTGCGGGTAAAGACCCTGCGGGAC
CTGATCCATGGAGCTCCTGTGGGCAAGCCAGCTGCCAACCGGGCCTTTGTCAGCATGGTCTACTCTGAGGAGGGTGCTGAGGACCGTACC
TTTGCCCGTGTCATTGTAGGAGGTTCTTCTGAGTACAAGATCAACAACAAAGTGGTCCAACTACATGAGTACAGTGAGGAATTAGAGAAG
TTGGGCATTCTCATCAAAGCTCGTAACTTCCTCGTTTTCCAGGGTGCTGTGGAATCTATTGCCATGAAGAACCCCAAAGAGAGGACAGCT
CTATTTGAAGAGATTAGTCGTTCTGGGGAGCTGGCGCAGGAGTATGACAAGCGAAAGAAGGAAATGGTGAAGGCTGAAGAGGACACACAG
TTTAATTACCATCGCAAGAAAAATATTGCGGCTGAACGCAAGGAAGCAAAGCAGGAGAAAGAAGAGGCTGACCGGTACCAGCGCCTGAAG
GATGAGGTAGTACGGGCTCAGGTACAGCTGCAGCTCTTTAAGCTTTACCATAATGAAGTGGAAATTGAGAAGCTCAACAAGGAACTGGCC
TCAAAGAACAAGGAGATCGAGAAGGACAAGAAGCGTATGGACAAGGTGGAGGATGAACTGAAGGAGAAGAAGAAGGAGCTGGGCAAAATG
ATGCGGGAGCAGCAGCAGATTGAGAAGGAGATCAAGGAGAAGGACTCAGAATTGAACCAGAAGCGGCCTCAGTACATCAAAGCCAAGGAG
AACACCTCCCACAAAATCAAGAAGCTGGAAGCAGCCAAGAAGTCTCTGCAGAATGCTCAGAAGCACTACAAGAAGCGTAAAGGTGACATG
GATGAGCTGGAGAAGGAGATGCTGTCAGTGGAGAAGGCTCGGCAGGAGTTTGAAGAACGGATGGAAGAAGAGAGTCAGAGTCAGGGCAGA
GATTTGACGTTGGAGGAGAATCAGGTGAAGAAATACCACCGGTTGAAAGAAGAAGCCAGCAAGAGAGCAGCTACCCTGGCCCAGGAGCTG
GAGAAATTCAATCGAGACCAGAAAGCTGACCAGGACCGTCTGGATCTGGAAGAACGGAAGAAAGTAGAGACAGAGGCCAAGATCAAGCAA
AAGCTGCGGGAAATTGAAGAGAATCAGAAGCGGATTGAGAAACTGGAGGAATACATCACCACTAGCAAGCAGTCCCTAGAAGAGCAGAAG
AAGCTAGAGGGGGAGCTGACAGAGGAGGTGGAGATGGCCAAGCGGCGTATTGATGAAATCAATAAGGAGCTGAACCAGGTGATGGAGCAG
CTAGGGGATGCCCGCATCGACCGCCAGGAGAGCAGCCGCCAGCAGCGAAAGGCAGAGATAATGGAAAGCATCAAGCGCCTTTACCCTGGC
TCTGTGTACGGCCGCCTCATTGACCTATGCCAGCCCACACAAAAGAAGTATCAGATTGCTGTAACCAAGGTTTTGGGCAAGAACATGGAT
GCCATTATTGTGGACTCGGAGAAGACAGGCCGGGACTGTATTCAGTATATCAAGGAGCAGCGTGGGGAGCCTGAGACCTTCTTGCCTCTT
GACTACCTGGAGGTGAAGCCTACAGATGAGAAACTCCGGGAGCTGAAGGGGGCCAAGCTAGTGATTGATGTGATTCGCTATGAGCCACCT
CATATCAAAAAGGCCCTGCAGTATGCTTGTGGCAATGCCCTTGTCTGTGACAACGTGGAAGATGCCCGCCGCATTGCCTTTGGAGGCCAC
CAGCGCCACAAGACAGTGGCACTGGATGGAACCCTATTCCAGAAGTCAGGAGTGATCTCTGGTGGGGCCAGTGACCTGAAGGCCAAGGCA
CGGCGCTGGGATGAGAAAGCAGTAGACAAGTTGAAAGAGAAGAAGGAGCGCTTGACAGAGGAGCTGAAAGAGCAGATGAAGGCAAAACGG
AAAGAGGCAGAGCTGCGTCAGGTGCAGTCTCAGGCCCATGGACTGCAGATGCGGCTCAAGTACTCCCAGAGTGACCTAGAACAGACCAAG
ACACGACATCTAGCCCTGAATCTGCAGGAAAAATCCAAGCTGGAGAGTGAGCTAGCCAACTTTGGGCCTCGCATTAATGATATCAAGAGG
ATCATTCAGAGCCGAGAGAGGGAAATGAAAGACTTGAAGGAGAAGATGAACCAGGTAGAGGATGAGGTGTTTGAAGAGTTTTGTCGGGAG
ATTGGTGTGCGCAACATCCGGGAGTTTGAGGAAGAAAAGGTGAAACGGCAGAATGAAATCGCCAAGAAGCGTTTGGAGTTTGAGAATCAG
AAGACTCGCTTGGGCATTCAGTTGGATTTTGAAAAGAACCAACTGAAGGAGGACCAAGATAAAGTACACATGTGGGAGCAGACAGTGAAA
AAAGATGAAAATGAGATAGAAAAGCTCAAAAAGGAGGAACAAAGACACATGAAGATCATAGATGAGACCATGGCTCAGCTACAAGACCTG
AAGAATCAGCATCTGGCCAAGAAGTCGGAAGTGAATGACAAGAATCATGAGATGGAGGAGATTCGTAAGAAACTCGGGGGCGCCAACAAG
GAAATGACCCATTTACAGAAGGAGGTGACAGCCATTGAGACCAAGCTTGAACAGAAGCGCAGTGACCGTCACAACTTGCTACAGGCCTGT
AAGATGCAGGACATTAAGTTGCCACTGTCAAAAGGCACCATGGATGATATTAGTCAGGAAGAGGGTAGCTCCCAGGGGGAGGACTCAGTG
AGTGGTTCACAGAGAATTTCCAGTATCTATGCACGAGAGGCCCTCATTGAGATTGACTACGGTGATCTGTGTGAGGATCTGAAGGATGCC
CAGGCTGAGGAAGAGATCAAGCAAGAGATGAACACACTGCAGCAGAAGCTGAATGAGCAGCAGAGTGTGCTTCAGCGTATTGCCGCCCCC
AACATGAAGGCCATGGAAAAGCTGGAAAGTGTCCGAGACAAGTTCCAGGAGACCTCAGATGAGTTTGAAGCAGCCCGAAAGCGAGCAAAG
AAGGCCAAGCAGGCATTCGAACAGATCAAGAAGGAGCGCTTTGACCGCTTCAATGCTTGTTTTGAATCTGTGGCTACCAACATTGATGAG
ATCTATAAGGCCCTGTCCCGCAATAGCAGTGCCCAGGCATTCCTGGGCCCTGAGAACCCTGAAGAGCCCTACTTGGATGGCATCAACTAC
AACTGTGTGGCTCCTGGGAAACGCTTCCGGCCTATGGACAACTTGTCAGGCGGGGAGAAGACAGTGGCAGCTCTGGCCCTGCTCTTTGCC
ATCCACAGCTACAAGCCAGCCCCCTTCTTCGTCCTGGATGAGATTGATGCTGCCTTGGATAACACCAACATTGGCAAGGTGGCAAATTAC
ATCAAGGAGCAGTCGACTTGCAACTTCCAGGCCATCGTCATCTCTCTCAAGGAGGAGTTCTACACCAAGGCCGAGAGCCTCATTGGAGTC
TATCCTGAGCAAGGGGACTGTGTGATCAGCAAAGTCCTGACCTTCGACCTCACCAAGTACCCAGATGCCAACCCCAACCCCAATGAGCAG
TAGCAGTATTTTTGCCCTCCCGCCCTGTCTGGATCCCTAAGCTGTCCCTCTCCCAATCTCTGGATATTTGACTCCCAACCTTCCCCCTAC
CTCCTGGCCCTTTTTGGTGTAGTCATGGGATTTAGGCACTGCTAATCAAGCATGAAGAGGAACAGAGGTGATGTTAGGTCTGGAGCAAAA
ATTCCTGAACGACAGGGAGTATTCTGGCCTCTGAAAGGAGGTGCTGAGCTGAACAGGGCCATCTGTTCATCACACACACCCCCTTCCTCC
CCCTCATCACCCATAATCGTGGGCCCCTTGGGCCTCTTGCCCACTGTGTGTGTGGGTATGTATGTGTGTATGTATGTATCCGCATGTGTG
CATGTGAGTATGTTTGCAAAATAATAAAGGATATTGGAGACCTGTTTTAGAAGGAGCCTAGGCTGAATTTGATTCCAAGAGAGCTTAGGA
TGACAGCACCCCTGAGCTGGGCAAAGGTACTCAGGACCTCATAGGAGTCTTAGGCAGTTACCTGAAACTGCCTTCATTCACTCATTTGTG
TATTCATTCATTTATGTATTCATCAGACACATACCGAACACCCTCTATTTGTCAGGCTCTGTGCTTGGAATACAGAGTTGAATCAGACAT
GATCTCTACCCTCCTAGTAAGGAGATACAGTGGGTTCATGAATGACTATAGTTAGCTGAATGTCATATGTACTTTGAATTTGAGAAGTGG
GTGATCCCCTCTAGGCTTCCTGGAGGTCACATTTAAGCTAGACCTTGACAAATTGGTAGGATTTGGTCAGGCACTAGGAGTGGAGCATGA
GCTCTGGGGACAGACAGTTATGGGTTCTGGTCCCACTTTTTATCACTTACTAGTTGTTTGACCTTGGGCAAGTCATTTGACCTTCTGTGC
CTCAGTTTCCTCATCTGTAAAATGGGGCTAACAATATTACCTACCTCATAGGATTTAATGATGTCAAGCTCCTCACTGGAGGCCTTATCC
CTTCGTGGAGCCCACTAGGTGCCGACCCCTCAGAATATAACCCTCATGCCTGGACCCCTGAGAGCTTCTGATCCCAGCTATTAGGGACAG
AAGAAGCCTCCAAATCTGGAAGGTGCTGAATGCCCTGCTGACTGGGAAAGTTTCAGGGCACTGATGGGGTCTACCTGGTAAGCGGAGGGC
CTGAGGAAACCTGTAGCTTCAATCATGTCTGGTAACCGGGTGCCTGAGCCCCAATCTGGGTTGTGAGGAAATAGGGGAGAGGTATCCTGG
GCCACATCCCAGCCTAACACCTGTGAGGTTCATTTTAGGAACTAACCTCATTAGCTATAAGGATCATGCAGAGGCAGCAAAGCCGGGTGC
GATGAGCTCAGCCTTTACTCATTCACATACACCATCACACTTTAATTCCAATCTGTATATTGCTTTTTAAAAGTTAAGTCCATTCTAATT
ACCCAAATATGCATGAATTCATTCTCCTTTTGAGAAGTTAGATTGTTAAAGATAGTCTCATTCAGCTACCAACCACTCCTTGATCCTTCC
CTTCTTAGTGGCTGTTGTTTGTTGTACTTCCGTTTAGACTTTGTTTTAATGCTTGTACGTACATATGTGAACTCATTGGAAATATTGTGT
GTTTAATGCAAATGATATATTGAATTGTTTAGCAATTTGTTTTCTTTGCTTAACGATGTTTTTGAGATCTGTGCATGTTACTTAATGTAG
CTCAATCCATCTTCTGTAATTGCTGTATAGATTGTCATCATATGATTACCACATTTTACTTACGCATTTCTTTTGTGATGGACATTAAGA
CTGTTTTTAGGTTTTGCTATTACAAAATACTACACAGGAGCATCACTATGCCTGTGTGAAAGTATATGTATGAAAGTTTACCTAGGGTTG
ATTCCTAGAAGTGGAATTGCAAAGTCATAGGATATTTATATATTGGTTTTTAATAATACTTCCAAATTGCCCTCCTGTACTATTTACTCA
GTATTTTTCTTGAGGTTGATCTGAGGTCTAACATTGTTATCCTATATCATTTTCATCCCAAGTAGTGATATCTGTGAAATCACAGGTTTG
ATGTGTGCTAATTATGTATTCTTCTAATACATATTAAAAGACATAACTATCAAAACAAAATAAATTTGTCTGTTTTCAACCAAAGAAGTC
ACGTACCACTGGTGGTACTGTGTGCCATAATTTGGCAAATGCTGGCCTTTATGGACGAGCACAATTCGGGGGTCAGACCTGGTTCAAATT
CTAGCTGTAGAAACTTGTGCAAGTTACTTCACCTCTGAGCCTAAGTTTCCACATCTGTAAAAGGAGATAATAAACACCTACCTTGCAGTA
GTGAAGCAAAGAGAAAATTAAATATATATGAAGCAATTTGGCTGGCATCTAGATCATTCACAGCCCTTTAAAGGTCACCTTTGCTGTTCT
CCCCACTTTACAGATAAGGAAACTGAGGCCCAAAAAGGTTTGAACCCAGGTCTTCCAAGTCATTCAAGTGCTTTCTCCACTGTACAGGTG
GTTATCAACCTTGGCTGCGCATCAGAATCGTTTGTAAAGCTTTTTCTTTTTCCTTTTTAAAAAGTAAAGCAATATATACACAGGTAAAAA
AATAAAATAGTACAGAAGGGCTTATAATGAGAAGCAGCAGTTCCCTGCTTGCACCCCCACATCCAAAGGATGTGGAGCTCTTTAAAAATA
AATTGCTCTGGTCCCACCTCTGGAAATCTGATTCAGCCAGCATGGATAATAACCCAGATAACTAACCCCTACCTCACAGGATAAAAAGGA
TTACATGAGATGCCTTAGGCTAAGGCCCTGGCACACAGGAACACATGTGCTACAAAGGAGCTTTGGGGACTTAAGTCCTGAGGATCCAGG
AGGTGAGGTGACTTGTCCAAGATTCCACTGGTTTAGTGGCAGAGCCTAGACTTCCACTCGGATCTATTTAGTGCTTGCCCCCTGCTCTCT
CCTGTCGTGCCCCACCACCTCCTGGCATCACAGGGCAACCGTTGTCAAGGCTATGCTCACGGGAGGCTGGGCACCACAGTGTTTCCAAGA
GCAAGCTGGATCCGAGTAGATTCCCTAGGGCTTGTTGGAGGAACTAGTTTGACTCCCTTATACTGTGGACGCAGTAGCCTTGCTGTAGGG
AGTTGAAGAGTACTCCACAACAGTATCTTAAGTTTAACTGGGCACTTCCCTCTGGAAATCACAGTGTTGTGCACCAGGAACACAAAGATG
AGTCAAATCTTTATCCTGCCTTTGAGGAGCTCACTGTTTAGTTGGGGAAACCATTTGTAAAACAGCCATTAACCATACAGTGTGATCAAC
ACTGACAGGAGCACAGGAAAAACATCTAGCTTATGTGAAGATTCAGAGAAGGCATCCTGTAGTCTAGGTGGTGATACCTGAACTGAGTCT
TGAGGGACGGGTAGGAATTAGCCAGTTGAGGAAGTAGAAGGAATTTCCAGATATTGGAAACAGTATGCATGAAGACATGAAGGCAAGAAA
CAGCAAAACAAATACTGAAGCATGAAGATTCCTGGGGTGGGGGGAAAGCAGCAAGAAAAGGTAGAGAGGAACCAGATTGGAAGAGGGTCG
TAAATGCATGGCTACAGAATTCAGATTTGTTTTGTAGGACAGTGTGGTTCCCAAACTGGCTGTATACCACAAACAGGTACGGCATTCTGG
GCCCCGGCCCCTAAAACATTCATTAAGTCTGGGGTGAAGATTTGGAATCTTGAATGCTTATAAAGGTTACCACATGACTAGGGTACAGCC
AGATTTGGAAACCATAGCTTGAAGGCAGTGAGGGAGCCATGAAATGGTTTTTAATAGGGGGACTCCAGATCAGATGTGAACTTAACCTGT
TTCTGGCTGGCTAGCCAACCAGCATGGAAAACAGATTAGGTTAGATGTTCATGCTGTATGTGCCCGTGCCTGTAGCTTCCCTGTTAATCA
GCTTCTTACACTACTATATTTGCTTATTTTGTCTCTGAATAAGCTTTAGGCACCACAAGGGTGGGCCTGGGGATATTTTGCTTACCAGTA
TAGCCCCTGCAAAAAAGCACAGTGCCTGACACAAAACAGGCACCCAGTAAAGTTTTTGAATGAATGAATGCATGAGTGAATCCATTTGTG
AGAGAGCGAATGGAGATGACAAGATTAGCTAGGAGACTGGAAAAAGACCAGGAGGCCTGCACTAGGGCAAAGGCCAGTAGGAATAGATTG
GAGGTGTTAAGGTGTGAACTGTTAAGGTAAGATGATAACTTAATGACTGATTATTGGATGTGGAGGGTGACTGAGAGGATAGAATGAGTA
CCCATGAATAGCCATGATTCCTACCCTGTCCCAGTCATCTCTTTCCTTATCCATCTCTGAAACAATCTGCTTACATCCTCCTCAGCAACT
GGAATTCCTCAAGTTAGTTAGACATTCTGTGTGCTGTGTGGTCTCTCACTGCCCCCCCACTCCCCACCCCTCCACAAGCCATTGATTCAT
TCATCCAGTTCAATAAATCTTGGCTAAGCACCTCCAGTGTGCAGTAAGGCTCTTCCAAGCCAGGACTCTGACTCCCTCTTTCCTACCTCA
AGAGATGTTTTTGAGGGCTTTCCCAGGTAAGAGTCACATCTCTTATACAATAACTTATAGTGAGATACCCAGAATGTCAGACTTGTAAGG
GAAGACTGCCCAAACCCCTTCTGAGGTCCTCAGAGGGGAATTAACTTCCTAAGGTCCGACTGCTAGGAAGTGTTGGAGCCAGAAATGGAA
CCTAGGTTTCCTTTCTATGTCATCTCTGGAGTCTTGATCTTGATCTATCCCATTGTAGATCAGGACAGGCAGAGGTGGTCAGGGAGAAGG
TGGGACTTAGGTTGAACCTTGAAGGTCAATGTATTGGACAGGTCAAACAAGATGGTTGCCAATTACACTGCCCCCTTCTGGAAACCCTTA
GCAAACCTGCCATGCTTGCAGTCCCTTCTAAGGGGTTTCCTTAGCATAAGTTGCCATGCTCTGTACCATGTGACCTCACAATCCTGGCCA
CAGATAGCTAGATGTGGATAGTGTCTGGTTCAAGGGCAACCAATCTCTAGGCTGGCCAGTGGCCTGTTAGCTGGACTGGCATAAGGACTT
CACCTTACAGGGGTGGCATGTATCAAATGGCAAATGTATGAAACAACCAGATCTTTCAGGGAGGCAGAATGTGAGCTATTCAGAAGAAGT
GAACGTTAATTAGAATTTAATGAGGCATTAGTGGTGGTGGATGAGGGGTGGCCAGAAACTAAACAGCAAAAGCAAAGAGAAAGCTGCAGA
AACCATAAGTAAGCAGAGGTCATGAGACATTTGTATAATGAGATCACGGAGCCACAGGGTGGCAGAAGCCATGAAGCAGCAAGGCAACAA
TGGGCTAGAAGCCATGAAGCAATAGGAGCCACGAGGAACAGAAACCGTGAGACAAAACTGACTATGAGATCCACAAAGCAGCAGAAGGCT
TGAATAGATAAGATCATGAGACAGTAGAAGCGATGAGACTGCAAGAACCACAAGGTAGCCAGAACCATGTGGCAACATGGCAACAGGAAT
GGAAGAGGCAGCAGGAGCTACAATGCAGAAAAGCCATGGATTAATAGGAACTGAAGCGCCGGGAGCCATGAAGCTGCAGGACCCATGAGG
CAGAAAAAGCCATGGGCTAGCATCGAGGGGGGCAGAAAGAAGTTAGTCAGTAGCAGTAGGAGGAGTATAAATACAGCCAGAAAGGAGTTG
AGTCACCAATTTGGGAAGCACTAGAGAAGGGAGCAACAGATGCCTGCAGCTGAGGGGGTGACAAGATAAGCCAGGCTCTAGAGCTGCTTT
GGATCATGAACCATTTTCAAGTTTCTGTTCTTCCATGAGGCTGCCTGTGTAGCTGTTCTTGTCTTCCTTATTTCCCTGTGAATGCTTTAA

>10359_10359_2_BRWD1-SMC1A_BRWD1_chr21_40568424_ENST00000380800_SMC1A_chrX_53442118_ENST00000322213_length(amino acids)=3418AA_BP=2221
MRRGDASPVRPRRGLHAPLARSLPPPAPRPAMAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEH
NRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNL
VEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYE
NTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLC
SSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSS
EEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFN
MIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNP
HPTKYQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIRQLQQQQDQRMGADQDTIPRGLSNGEETPR
RGFRRLSLDIQSPPNIGLRRSGQVEGVRQMHQNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQ
LSHKSDSVVLVSQSRQRTCRRKYPNYGRRNRSWRELSSGNESSSSVRHETSCDQSEGSGSSEEDEWRSDRKSESYSESSSDSSSRYSDWT
ADAGINLQPPLRTSCRRRITRFCSSSEDEISTENLSPPKRRRKRKKENKPKKENLRRMTPAELANMEHLYEFHPPVWITDTTLRKSPFVP
QMGDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIVGIRYEVGPPTLCCLKLAFIDPATGKLMDKSFSIRYHDMPDV
IDFLVLRQFYDEARQRNWQSCDRFRSIIDDAWWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASIS
VTTDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTVVAYPTDLYTIRMRLVNRFYRRLSALVWEV
RYIEHNARTFNEPESVIARSAKKITDQLLKFIKNQHCTNISELSNTSENDEQNAEDLDDSDLPKTSSGRRRVHDGKKSIRATNYVESNWK
KQCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLDAGNYDSPLEFCKDIRLIFSNAKAYTPNKRSKIYSMTLRLSA
LFEEKMKKISSDFKIGQKFNEKLRRSQRFKQRQNCKGDSQPNKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSRTAYLGTHKTSAGISSG
VTSGDSSDSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARESSSRSGLSRSSNLRVTRTRAAQRKTGPVSL
ANGCGRKATRKRVYLSDSDNNSLETGEILKARAGNNRKVLRKCAAVAANKIKLMSDVEENSSSESVCSGRKLPHRNASAVARKKLLHNSE
DEQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESESDLRVARKNWHANGYKSHTPAPSKTKFLKIESSEEDSKSHDSDHAC
NRTAGPSTSVQKLKAESISEEADSEPGRSGGRKYNTFHKNASFFKKTKILSDSEDSESEEQDREDGKCHKMEMNPISGNLNCDPIAMSQC
SSDHGCETDLDSDDDKIEKPNNFMKDSASQDNGLSRKISRKRVCSSDSDSSLQVVKKSSKARTGLLRITRRCAATAANKIKLMSDVEDVS
LENVHTRSKNGRKKPLHLACTTAKKKLSDCEGSVHCEVPSEQYACEGKPPDPDSEGSTKVLSQALNGDSDSEDMLNSEHKHRHTNIHKID
APSKRKSSSVTSSGEDSKSHIPGSETDRTFSSESTLAQKATAENNFEVELNYGLRRWNGRRLRTYGKAPFSKTKVIHDSQETAEKEVKRK
RSHPELENVKISETTGNSKFRPDTSSKSSDLGSVTESDIDCTDNTKTKRRKTKGKAKVVRKGKSNLMDAISFVLGEKTSNLRVKTLRDLI
HGAPVGKPAANRAFVSMVYSEEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALF
EEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASK
NKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDE
LEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKL
REIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSV
YGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHI
KKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKE
AELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIG
VRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKN
QHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSG
SQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKA
KQAFEQIKKERFDRFNACFESVATNIDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALALLFAIH

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Fusion Gene PPI Analysis for BRWD1-SMC1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BRWD1-SMC1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BRWD1-SMC1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBRWD1C0028960Oligospermia1CTD_human
TgeneC1802395Congenital muscular hypertrophy-cerebral syndrome9CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0543888Epileptic encephalopathy2GENOMICS_ENGLAND
TgeneC0005684Malignant neoplasm of urinary bladder1CTD_human
TgeneC0005695Bladder Neoplasm1CTD_human
TgeneC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneC0014544Epilepsy1CTD_human
TgeneC0023466Leukemia, Monocytic, Chronic1CTD_human
TgeneC0023470Myeloid Leukemia1CTD_human
TgeneC0023487Acute Promyelocytic Leukemia1GENOMICS_ENGLAND
TgeneC0036572Seizures1GENOMICS_ENGLAND
TgeneC0086237Epilepsy, Cryptogenic1CTD_human
TgeneC0236018Aura1CTD_human
TgeneC0751111Awakening Epilepsy1CTD_human
TgeneC1535926Neurodevelopmental Disorders1CTD_human
TgeneC1854630Growth Deficiency and Mental Retardation with Facial Dysmorphism1ORPHANET