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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATRX-DYM (FusionGDB2 ID:HG546TG54808)

Fusion Gene Summary for ATRX-DYM

check button Fusion gene summary
Fusion gene informationFusion gene name: ATRX-DYM
Fusion gene ID: hg546tg54808
HgeneTgene
Gene symbol

ATRX

DYM

Gene ID

546

54808

Gene nameATRX chromatin remodelerdymeclin
SynonymsJMS|MRX52|RAD54|RAD54L|XH2|XNP|ZNF-HXDMC|SMC
Cytomap('ATRX')('DYM')

Xq21.1

18q21.1

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional regulator ATRXATP-dependent helicase ATRXX-linked helicase IIX-linked nuclear proteinalpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)dymeclindyggve-Melchior-Clausen syndrome protein
Modification date2020031320200313
UniProtAcc.

Q7RTS9

Ensembl transtripts involved in fusion geneENST00000373344, ENST00000395603, 
ENST00000480283, ENST00000373341, 
Fusion gene scores* DoF score17 X 13 X 9=198919 X 11 X 13=2717
# samples 2324
** MAII scorelog2(23/1989*10)=-3.11233750988937
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/2717*10)=-3.50090825461346
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATRX [Title/Abstract] AND DYM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATRX(77041467)-DYM(46645296), # samples:1
Anticipated loss of major functional domain due to fusion event.ATRX-DYM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATRX-DYM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATRX

GO:0006334

nucleosome assembly

20651253

HgeneATRX

GO:0006338

chromatin remodeling

20651253


check buttonFusion gene breakpoints across ATRX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across DYM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A91EATRXchrX

77041467

-DYMchr18

46645296

-


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Fusion Gene ORF analysis for ATRX-DYM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000373344ENST00000578396ATRXchrX

77041467

-DYMchr18

46645296

-
5CDS-intronENST00000373344ENST00000584977ATRXchrX

77041467

-DYMchr18

46645296

-
5CDS-intronENST00000395603ENST00000578396ATRXchrX

77041467

-DYMchr18

46645296

-
5CDS-intronENST00000395603ENST00000584977ATRXchrX

77041467

-DYMchr18

46645296

-
5UTR-3CDSENST00000480283ENST00000269445ATRXchrX

77041467

-DYMchr18

46645296

-
5UTR-3CDSENST00000480283ENST00000442713ATRXchrX

77041467

-DYMchr18

46645296

-
5UTR-intronENST00000480283ENST00000578396ATRXchrX

77041467

-DYMchr18

46645296

-
5UTR-intronENST00000480283ENST00000584977ATRXchrX

77041467

-DYMchr18

46645296

-
In-frameENST00000373344ENST00000269445ATRXchrX

77041467

-DYMchr18

46645296

-
In-frameENST00000373344ENST00000442713ATRXchrX

77041467

-DYMchr18

46645296

-
In-frameENST00000395603ENST00000269445ATRXchrX

77041467

-DYMchr18

46645296

-
In-frameENST00000395603ENST00000442713ATRXchrX

77041467

-DYMchr18

46645296

-
intron-3CDSENST00000373341ENST00000269445ATRXchrX

77041467

-DYMchr18

46645296

-
intron-3CDSENST00000373341ENST00000442713ATRXchrX

77041467

-DYMchr18

46645296

-
intron-intronENST00000373341ENST00000578396ATRXchrX

77041467

-DYMchr18

46645296

-
intron-intronENST00000373341ENST00000584977ATRXchrX

77041467

-DYMchr18

46645296

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373344ATRXchrX77041467-ENST00000442713DYMchr1846645296-1068235271681136
ENST00000373344ATRXchrX77041467-ENST00000269445DYMchr1846645296-917235271681136
ENST00000395603ATRXchrX77041467-ENST00000442713DYMchr1846645296-1068235271681136
ENST00000395603ATRXchrX77041467-ENST00000269445DYMchr1846645296-917235271681136

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373344ENST00000442713ATRXchrX77041467-DYMchr1846645296-0.005911220.99408877
ENST00000373344ENST00000269445ATRXchrX77041467-DYMchr1846645296-0.0093248460.99067515
ENST00000395603ENST00000442713ATRXchrX77041467-DYMchr1846645296-0.005911220.99408877
ENST00000395603ENST00000269445ATRXchrX77041467-DYMchr1846645296-0.0093248460.99067515

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Fusion Genomic Features for ATRX-DYM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ATRX-DYM


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:77041467/chr18:46645296)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DYM

Q7RTS9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Necessary for correct organization of Golgi apparatus. Involved in bone development. {ECO:0000269|PubMed:21280149}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATRXchrX:77041467chr18:46645296ENST00000373344-1351151_115662493.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041467chr18:46645296ENST00000373344-1351166_116962493.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041467chr18:46645296ENST00000373344-1351202_120662493.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041467chr18:46645296ENST00000373344-1351259_126662493.0Compositional biasNote=Poly-Asp
HgeneATRXchrX:77041467chr18:46645296ENST00000373344-1351443_146662493.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041467chr18:46645296ENST00000373344-1351499_150262493.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041467chr18:46645296ENST00000373344-1351929_193962493.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041467chr18:46645296ENST00000373344-1351941_194862493.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041467chr18:46645296ENST00000373344-1352222_222562493.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041467chr18:46645296ENST00000373344-1352262_226562493.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041467chr18:46645296ENST00000373344-1352420_242562493.0Compositional biasNote=Poly-Gln
HgeneATRXchrX:77041467chr18:46645296ENST00000373344-135745_75062493.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041467chr18:46645296ENST00000395603-1341151_115662455.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041467chr18:46645296ENST00000395603-1341166_116962455.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041467chr18:46645296ENST00000395603-1341202_120662455.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041467chr18:46645296ENST00000395603-1341259_126662455.0Compositional biasNote=Poly-Asp
HgeneATRXchrX:77041467chr18:46645296ENST00000395603-1341443_146662455.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041467chr18:46645296ENST00000395603-1341499_150262455.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041467chr18:46645296ENST00000395603-1341929_193962455.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041467chr18:46645296ENST00000395603-1341941_194862455.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041467chr18:46645296ENST00000395603-1342222_222562455.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041467chr18:46645296ENST00000395603-1342262_226562455.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041467chr18:46645296ENST00000395603-1342420_242562455.0Compositional biasNote=Poly-Gln
HgeneATRXchrX:77041467chr18:46645296ENST00000395603-134745_75062455.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041467chr18:46645296ENST00000373344-1351581_176862493.0DomainHelicase ATP-binding
HgeneATRXchrX:77041467chr18:46645296ENST00000373344-135159_29662493.0DomainADD
HgeneATRXchrX:77041467chr18:46645296ENST00000373344-1352025_220562493.0DomainHelicase C-terminal
HgeneATRXchrX:77041467chr18:46645296ENST00000395603-1341581_176862455.0DomainHelicase ATP-binding
HgeneATRXchrX:77041467chr18:46645296ENST00000395603-134159_29662455.0DomainADD
HgeneATRXchrX:77041467chr18:46645296ENST00000395603-1342025_220562455.0DomainHelicase C-terminal
HgeneATRXchrX:77041467chr18:46645296ENST00000373344-1351719_172262493.0MotifNote=DEGH box
HgeneATRXchrX:77041467chr18:46645296ENST00000373344-135581_59462493.0MotifNote=PxVxL motif
HgeneATRXchrX:77041467chr18:46645296ENST00000395603-1341719_172262455.0MotifNote=DEGH box
HgeneATRXchrX:77041467chr18:46645296ENST00000395603-134581_59462455.0MotifNote=PxVxL motif
HgeneATRXchrX:77041467chr18:46645296ENST00000373344-1351594_160162493.0Nucleotide bindingATP
HgeneATRXchrX:77041467chr18:46645296ENST00000395603-1341594_160162455.0Nucleotide bindingATP
HgeneATRXchrX:77041467chr18:46645296ENST00000373344-135170_20662493.0Zinc fingerGATA-type%3B atypical
HgeneATRXchrX:77041467chr18:46645296ENST00000373344-135217_27262493.0Zinc fingerPHD-type%3B atypical
HgeneATRXchrX:77041467chr18:46645296ENST00000395603-134170_20662455.0Zinc fingerGATA-type%3B atypical
HgeneATRXchrX:77041467chr18:46645296ENST00000395603-134217_27262455.0Zinc fingerPHD-type%3B atypical


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Fusion Gene Sequence for ATRX-DYM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8350_8350_1_ATRX-DYM_ATRX_chrX_77041467_ENST00000373344_DYM_chr18_46645296_ENST00000269445_length(transcript)=917nt_BP=235nt
CTCGGCCCAACAAAATGGCGGCGGCAGCGGTGTCGCTTTGTTTCCGCGGCTCCTGCGGCGGTGGCAGTGGTAGCGGCCTTTGAGCTGTGG
GGAGGTTCCAGCAGCAGCTACAGTGACGACTAAGACTCCAGTGCATTTCTATCGTAACCGGGCGCGGGGGAGCGCAGATCGGCGCCCAGC
AATCACAGAAGCCGACAAGGCGTTCAAGCGAAAACATGACCGCTGAGCCCATGAGGCACAAGACCTAAATGTCATTGAAGAAGTGATTCG
AATGATGTTAGAGATCATCAACTCCTGCCTGACAAATTCCCTTCACCACAACCCAAACTTGGTATACGCCCTGCTTTACAAACGCGATCT
CTTTGAACAATTTCGAACTCATCCTTCATTTCAGGATATAATGCAAAATATTGATCTGGTGATCTCCTTCTTTAGCTCAAGGTTGCTGCA
AGCTGGAGCTGAGCTGTCAGTGGAACGGGTCCTGGAAATCATTAAGCAAGGCGTCGTTGCGCTGCCCAAAGACAGACTGAAGAAATTTCC
AGAATTGAAATTCAAATATGTGGAAGAGGAGCAGCCCGAGGAGTTTTTTATCCCCTATGTCTGGTCTCTTGTCTACAACTCAGCAGTCGG
CCTGTACTGGAATCCACAGGACATCCAGCTGTTCACCATGGATTCCGACTGAGGGCAGGATGCTCTCCCACCCGGACCCCTCCAGCCAAG
CAGCCCTTCAAGTTCTTTTATTTCTGGGTAACAGAAGTAGACAGACAGGTTACTTGGTGTATCTTCTGTTAAAGAGGATTGCACGAGTGT
GTTTTCCTCACACACTTTGATTTGGAGAATTGGTGCTAGTTGGCAATAGATAACTCAGCGTAGATAGTATTGCAAAAAGGGGAGGAAATA

>8350_8350_1_ATRX-DYM_ATRX_chrX_77041467_ENST00000373344_DYM_chr18_46645296_ENST00000269445_length(amino acids)=136AA_BP=
MMLEIINSCLTNSLHHNPNLVYALLYKRDLFEQFRTHPSFQDIMQNIDLVISFFSSRLLQAGAELSVERVLEIIKQGVVALPKDRLKKFP

--------------------------------------------------------------
>8350_8350_2_ATRX-DYM_ATRX_chrX_77041467_ENST00000373344_DYM_chr18_46645296_ENST00000442713_length(transcript)=1068nt_BP=235nt
CTCGGCCCAACAAAATGGCGGCGGCAGCGGTGTCGCTTTGTTTCCGCGGCTCCTGCGGCGGTGGCAGTGGTAGCGGCCTTTGAGCTGTGG
GGAGGTTCCAGCAGCAGCTACAGTGACGACTAAGACTCCAGTGCATTTCTATCGTAACCGGGCGCGGGGGAGCGCAGATCGGCGCCCAGC
AATCACAGAAGCCGACAAGGCGTTCAAGCGAAAACATGACCGCTGAGCCCATGAGGCACAAGACCTAAATGTCATTGAAGAAGTGATTCG
AATGATGTTAGAGATCATCAACTCCTGCCTGACAAATTCCCTTCACCACAACCCAAACTTGGTATACGCCCTGCTTTACAAACGCGATCT
CTTTGAACAATTTCGAACTCATCCTTCATTTCAGGATATAATGCAAAATATTGATCTGGTGATCTCCTTCTTTAGCTCAAGGTTGCTGCA
AGCTGGAGCTGAGCTGTCAGTGGAACGGGTCCTGGAAATCATTAAGCAAGGCGTCGTTGCGCTGCCCAAAGACAGACTGAAGAAATTTCC
AGAATTGAAATTCAAATATGTGGAAGAGGAGCAGCCCGAGGAGTTTTTTATCCCCTATGTCTGGTCTCTTGTCTACAACTCAGCAGTCGG
CCTGTACTGGAATCCACAGGACATCCAGCTGTTCACCATGGATTCCGACTGAGGGCAGGATGCTCTCCCACCCGGACCCCTCCAGCCAAG
CAGCCCTTCAAGTTCTTTTATTTCTGGGTAACAGAAGTAGACAGACAGGTTACTTGGTGTATCTTCTGTTAAAGAGGATTGCACGAGTGT
GTTTTCCTCACACACTTTGATTTGGAGAATTGGTGCTAGTTGGCAATAGATAACTCAGCGTAGATAGTATTGCAAAAAGGGGAGGAAATA
CACAACAATAATAAATGTAAAAACCTGCTATTCAACATGCAGTTTTATTTCGAAGCCAAAAATCTAGAGCTTTCCCAAGATCCTGTTGCC

>8350_8350_2_ATRX-DYM_ATRX_chrX_77041467_ENST00000373344_DYM_chr18_46645296_ENST00000442713_length(amino acids)=136AA_BP=
MMLEIINSCLTNSLHHNPNLVYALLYKRDLFEQFRTHPSFQDIMQNIDLVISFFSSRLLQAGAELSVERVLEIIKQGVVALPKDRLKKFP

--------------------------------------------------------------
>8350_8350_3_ATRX-DYM_ATRX_chrX_77041467_ENST00000395603_DYM_chr18_46645296_ENST00000269445_length(transcript)=917nt_BP=235nt
CTCGGCCCAACAAAATGGCGGCGGCAGCGGTGTCGCTTTGTTTCCGCGGCTCCTGCGGCGGTGGCAGTGGTAGCGGCCTTTGAGCTGTGG
GGAGGTTCCAGCAGCAGCTACAGTGACGACTAAGACTCCAGTGCATTTCTATCGTAACCGGGCGCGGGGGAGCGCAGATCGGCGCCCAGC
AATCACAGAAGCCGACAAGGCGTTCAAGCGAAAACATGACCGCTGAGCCCATGAGGCACAAGACCTAAATGTCATTGAAGAAGTGATTCG
AATGATGTTAGAGATCATCAACTCCTGCCTGACAAATTCCCTTCACCACAACCCAAACTTGGTATACGCCCTGCTTTACAAACGCGATCT
CTTTGAACAATTTCGAACTCATCCTTCATTTCAGGATATAATGCAAAATATTGATCTGGTGATCTCCTTCTTTAGCTCAAGGTTGCTGCA
AGCTGGAGCTGAGCTGTCAGTGGAACGGGTCCTGGAAATCATTAAGCAAGGCGTCGTTGCGCTGCCCAAAGACAGACTGAAGAAATTTCC
AGAATTGAAATTCAAATATGTGGAAGAGGAGCAGCCCGAGGAGTTTTTTATCCCCTATGTCTGGTCTCTTGTCTACAACTCAGCAGTCGG
CCTGTACTGGAATCCACAGGACATCCAGCTGTTCACCATGGATTCCGACTGAGGGCAGGATGCTCTCCCACCCGGACCCCTCCAGCCAAG
CAGCCCTTCAAGTTCTTTTATTTCTGGGTAACAGAAGTAGACAGACAGGTTACTTGGTGTATCTTCTGTTAAAGAGGATTGCACGAGTGT
GTTTTCCTCACACACTTTGATTTGGAGAATTGGTGCTAGTTGGCAATAGATAACTCAGCGTAGATAGTATTGCAAAAAGGGGAGGAAATA

>8350_8350_3_ATRX-DYM_ATRX_chrX_77041467_ENST00000395603_DYM_chr18_46645296_ENST00000269445_length(amino acids)=136AA_BP=
MMLEIINSCLTNSLHHNPNLVYALLYKRDLFEQFRTHPSFQDIMQNIDLVISFFSSRLLQAGAELSVERVLEIIKQGVVALPKDRLKKFP

--------------------------------------------------------------
>8350_8350_4_ATRX-DYM_ATRX_chrX_77041467_ENST00000395603_DYM_chr18_46645296_ENST00000442713_length(transcript)=1068nt_BP=235nt
CTCGGCCCAACAAAATGGCGGCGGCAGCGGTGTCGCTTTGTTTCCGCGGCTCCTGCGGCGGTGGCAGTGGTAGCGGCCTTTGAGCTGTGG
GGAGGTTCCAGCAGCAGCTACAGTGACGACTAAGACTCCAGTGCATTTCTATCGTAACCGGGCGCGGGGGAGCGCAGATCGGCGCCCAGC
AATCACAGAAGCCGACAAGGCGTTCAAGCGAAAACATGACCGCTGAGCCCATGAGGCACAAGACCTAAATGTCATTGAAGAAGTGATTCG
AATGATGTTAGAGATCATCAACTCCTGCCTGACAAATTCCCTTCACCACAACCCAAACTTGGTATACGCCCTGCTTTACAAACGCGATCT
CTTTGAACAATTTCGAACTCATCCTTCATTTCAGGATATAATGCAAAATATTGATCTGGTGATCTCCTTCTTTAGCTCAAGGTTGCTGCA
AGCTGGAGCTGAGCTGTCAGTGGAACGGGTCCTGGAAATCATTAAGCAAGGCGTCGTTGCGCTGCCCAAAGACAGACTGAAGAAATTTCC
AGAATTGAAATTCAAATATGTGGAAGAGGAGCAGCCCGAGGAGTTTTTTATCCCCTATGTCTGGTCTCTTGTCTACAACTCAGCAGTCGG
CCTGTACTGGAATCCACAGGACATCCAGCTGTTCACCATGGATTCCGACTGAGGGCAGGATGCTCTCCCACCCGGACCCCTCCAGCCAAG
CAGCCCTTCAAGTTCTTTTATTTCTGGGTAACAGAAGTAGACAGACAGGTTACTTGGTGTATCTTCTGTTAAAGAGGATTGCACGAGTGT
GTTTTCCTCACACACTTTGATTTGGAGAATTGGTGCTAGTTGGCAATAGATAACTCAGCGTAGATAGTATTGCAAAAAGGGGAGGAAATA
CACAACAATAATAAATGTAAAAACCTGCTATTCAACATGCAGTTTTATTTCGAAGCCAAAAATCTAGAGCTTTCCCAAGATCCTGTTGCC

>8350_8350_4_ATRX-DYM_ATRX_chrX_77041467_ENST00000395603_DYM_chr18_46645296_ENST00000442713_length(amino acids)=136AA_BP=
MMLEIINSCLTNSLHHNPNLVYALLYKRDLFEQFRTHPSFQDIMQNIDLVISFFSSRLLQAGAELSVERVLEIIKQGVVALPKDRLKKFP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ATRX-DYM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneATRXchrX:77041467chr18:46645296ENST00000373344-1351189_13266.6666666666666672493.0DAXX
HgeneATRXchrX:77041467chr18:46645296ENST00000395603-1341189_13266.6666666666666672455.0DAXX
HgeneATRXchrX:77041467chr18:46645296ENST00000373344-1352010_22806.6666666666666672493.0MECP2
HgeneATRXchrX:77041467chr18:46645296ENST00000395603-1342010_22806.6666666666666672455.0MECP2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATRX-DYM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATRX-DYM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATRXC0796003Juberg-Marsidi syndrome17CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneATRXC1845055ALPHA-THALASSEMIA/MENTAL RETARDATION SYNDROME, NONDELETION TYPE, X-LINKED16CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneATRXC0017638Glioma2CTD_human
HgeneATRXC0027819Neuroblastoma2CTD_human
HgeneATRXC0259783mixed gliomas2CTD_human
HgeneATRXC0555198Malignant Glioma2CTD_human
HgeneATRXC0010417Cryptorchidism1CTD_human
HgeneATRXC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneATRXC0018273Growth Disorders1CTD_human
HgeneATRXC0030297Pancreatic Neoplasm1CTD_human
HgeneATRXC0030846Penile Diseases1CTD_human
HgeneATRXC0039978Thoracic Diseases1CTD_human
HgeneATRXC0206754Neuroendocrine Tumors1CTD_human
HgeneATRXC0346647Malignant neoplasm of pancreas1CTD_human
HgeneATRXC0376634Craniofacial Abnormalities1CTD_human
HgeneATRXC0431663Bilateral Cryptorchidism1CTD_human
HgeneATRXC0431664Unilateral Cryptorchidism1CTD_human
HgeneATRXC0585216Alpha-Thalassemia Myelodysplasia Syndrome1CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneATRXC0796159Mental retardation Smith Fineman Myers type1ORPHANET
HgeneATRXC1136249Mental Retardation, X-Linked1CTD_human
HgeneATRXC1563730Abdominal Cryptorchidism1CTD_human
HgeneATRXC1563731Inguinal Cryptorchidism1CTD_human
HgeneATRXC2713368Hematopoetic Myelodysplasia1CTD_human
HgeneATRXC3463824MYELODYSPLASTIC SYNDROME1CTD_human
TgeneC0265286Dyggve-Melchior-Clausen syndrome5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC3888088SMITH-MCCORT DYSPLASIA 14GENOMICS_ENGLAND;UNIPROT
TgeneC1846431SMITH-MCCORT DYSPLASIA2CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0036341Schizophrenia1PSYGENET