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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:CTSA-ATP6V0A4 (FusionGDB2 ID:HG5476TG50617)

Fusion Gene Summary for CTSA-ATP6V0A4

Fusion gene summary

Fusion gene information	Fusion gene name: CTSA-ATP6V0A4
	Fusion gene ID: hg5476tg50617
		Hgene	Tgene
	Gene symbol	CTSA	ATP6V0A4
	Gene ID	5476	50617
	Gene name	cathepsin A	ATPase H+ transporting V0 subunit a4
	Synonyms	GLB2\|GSL\|NGBE\|PPCA\|PPGB	A4\|ATP6N1B\|ATP6N2\|RDRTA2\|RTA1C\|RTADR\|STV1\|VPH1\|VPP2
	Cytomap	('CTSA')('ATP6V0A4') 20q13.12	7q34
	Type of gene	protein-coding	protein-coding
	Description	lysosomal protective proteinbeta-galactosidase 2beta-galactosidase protective proteincarboxypeptidase Ccarboxypeptidase Y-like kininasecarboxypeptidase-Ldeamidaselysosomal carboxypeptidase Aprotective protein cathepsin Aurinary kininase	V-type proton ATPase 116 kDa subunit a isoform 4V-type proton ATPase 116 kDa subunit aATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1BATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic ac
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000191018, ENST00000354880, ENST00000372459, ENST00000372484,
Fusion gene scores	* DoF score	7 X 7 X 5=245	4 X 4 X 2=32
	# samples	8	4
	** MAII score	log2(8/245*10)=-1.61470984411521 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: CTSA [Title/Abstract] AND ATP6V0A4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CTSA(44526658)-ATP6V0A4(138406708), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CTSA	GO:0006508	proteolysis	12505983

Fusion gene breakpoints across CTSA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ATP6V0A4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BF823719	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+

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Fusion Gene ORF analysis for CTSA-ATP6V0A4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000191018	ENST00000483139	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+
5CDS-intron	ENST00000354880	ENST00000483139	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+
5CDS-intron	ENST00000372459	ENST00000483139	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+
5CDS-intron	ENST00000372484	ENST00000483139	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+
In-frame	ENST00000191018	ENST00000310018	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+
In-frame	ENST00000191018	ENST00000353492	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+
In-frame	ENST00000191018	ENST00000393054	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+
In-frame	ENST00000354880	ENST00000310018	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+
In-frame	ENST00000354880	ENST00000353492	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+
In-frame	ENST00000354880	ENST00000393054	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+
In-frame	ENST00000372459	ENST00000310018	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+
In-frame	ENST00000372459	ENST00000353492	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+
In-frame	ENST00000372459	ENST00000393054	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+
In-frame	ENST00000372484	ENST00000310018	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+
In-frame	ENST00000372484	ENST00000353492	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+
In-frame	ENST00000372484	ENST00000393054	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000372484	CTSA	chr20	44526658	-	ENST00000393054	ATP6V0A4	chr7	138406708	+	2460	1680	282	1685	467
ENST00000372484	CTSA	chr20	44526658	-	ENST00000310018	ATP6V0A4	chr7	138406708	+	2460	1680	282	1685	467
ENST00000372484	CTSA	chr20	44526658	-	ENST00000353492	ATP6V0A4	chr7	138406708	+	2229	1680	282	1685	467
ENST00000354880	CTSA	chr20	44526658	-	ENST00000393054	ATP6V0A4	chr7	138406708	+	2131	1351	4	1356	450
ENST00000354880	CTSA	chr20	44526658	-	ENST00000310018	ATP6V0A4	chr7	138406708	+	2131	1351	4	1356	450
ENST00000354880	CTSA	chr20	44526658	-	ENST00000353492	ATP6V0A4	chr7	138406708	+	1900	1351	4	1356	450
ENST00000191018	CTSA	chr20	44526658	-	ENST00000393054	ATP6V0A4	chr7	138406708	+	2209	1429	85	1434	449
ENST00000191018	CTSA	chr20	44526658	-	ENST00000310018	ATP6V0A4	chr7	138406708	+	2209	1429	85	1434	449
ENST00000191018	CTSA	chr20	44526658	-	ENST00000353492	ATP6V0A4	chr7	138406708	+	1978	1429	85	1434	449
ENST00000372459	CTSA	chr20	44526658	-	ENST00000393054	ATP6V0A4	chr7	138406708	+	2317	1537	193	1542	449
ENST00000372459	CTSA	chr20	44526658	-	ENST00000310018	ATP6V0A4	chr7	138406708	+	2317	1537	193	1542	449
ENST00000372459	CTSA	chr20	44526658	-	ENST00000353492	ATP6V0A4	chr7	138406708	+	2086	1537	193	1542	449

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000372484	ENST00000393054	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+	0.005933968	0.994066
ENST00000372484	ENST00000310018	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+	0.005933968	0.994066
ENST00000372484	ENST00000353492	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+	0.005899973	0.99410003
ENST00000354880	ENST00000393054	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+	0.005898973	0.994101
ENST00000354880	ENST00000310018	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+	0.005898973	0.994101
ENST00000354880	ENST00000353492	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+	0.005569542	0.9944305
ENST00000191018	ENST00000393054	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+	0.001382589	0.9986174
ENST00000191018	ENST00000310018	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+	0.001382589	0.9986174
ENST00000191018	ENST00000353492	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+	0.001717556	0.99828243
ENST00000372459	ENST00000393054	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+	0.001682181	0.99831784
ENST00000372459	ENST00000310018	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+	0.001682181	0.99831784
ENST00000372459	ENST00000353492	CTSA	chr20	44526658	-	ATP6V0A4	chr7	138406708	+	0.002036182	0.9979638

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Fusion Genomic Features for CTSA-ATP6V0A4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for CTSA-ATP6V0A4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:44526658/chr7:138406708)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000310018

1_390

841.0

Topological domain

Cytoplasmic

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000310018

410_411

841.0

Topological domain

Vacuolar

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000310018

429_443

841.0

Topological domain

Cytoplasmic

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000310018

474_538

841.0

Topological domain

Vacuolar

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000310018

559_576

841.0

Topological domain

Cytoplasmic

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000310018

598_642

841.0

Topological domain

Vacuolar

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000310018

663_727

841.0

Topological domain

Cytoplasmic

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000310018

753_773

841.0

Topological domain

Vacuolar

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000310018

813_840

841.0

Topological domain

Cytoplasmic

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000353492

1_390

841.0

Topological domain

Cytoplasmic

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000353492

410_411

841.0

Topological domain

Vacuolar

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000353492

429_443

841.0

Topological domain

Cytoplasmic

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000353492

474_538

841.0

Topological domain

Vacuolar

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000353492

559_576

841.0

Topological domain

Cytoplasmic

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000353492

598_642

841.0

Topological domain

Vacuolar

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000353492

663_727

841.0

Topological domain

Cytoplasmic

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000353492

753_773

841.0

Topological domain

Vacuolar

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000353492

813_840

841.0

Topological domain

Cytoplasmic

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000393054

1_390

841.0

Topological domain

Cytoplasmic

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000393054

410_411

841.0

Topological domain

Vacuolar

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000393054

429_443

841.0

Topological domain

Cytoplasmic

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000393054

474_538

841.0

Topological domain

Vacuolar

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000393054

559_576

841.0

Topological domain

Cytoplasmic

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000393054

598_642

841.0

Topological domain

Vacuolar

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000393054

663_727

841.0

Topological domain

Cytoplasmic

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000393054

753_773

841.0

Topological domain

Vacuolar

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000393054

813_840

841.0

Topological domain

Cytoplasmic

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000310018

391_409

841.0

Transmembrane

Helical

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000310018

412_428

841.0

Transmembrane

Helical

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000310018

444_473

841.0

Transmembrane

Helical

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000310018

539_558

841.0

Transmembrane

Helical

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000310018

577_597

841.0

Transmembrane

Helical

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000310018

643_662

841.0

Transmembrane

Helical

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000310018

728_752

841.0

Transmembrane

Helical

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000310018

774_812

841.0

Transmembrane

Helical

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000353492

391_409

841.0

Transmembrane

Helical

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000353492

412_428

841.0

Transmembrane

Helical

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000353492

444_473

841.0

Transmembrane

Helical

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000353492

539_558

841.0

Transmembrane

Helical

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000353492

577_597

841.0

Transmembrane

Helical

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000353492

643_662

841.0

Transmembrane

Helical

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000353492

728_752

841.0

Transmembrane

Helical

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000353492

774_812

841.0

Transmembrane

Helical

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000393054

391_409

841.0

Transmembrane

Helical

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000393054

412_428

841.0

Transmembrane

Helical

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000393054

444_473

841.0

Transmembrane

Helical

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000393054

539_558

841.0

Transmembrane

Helical

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000393054

577_597

841.0

Transmembrane

Helical

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000393054

643_662

841.0

Transmembrane

Helical

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000393054

728_752

841.0

Transmembrane

Helical

Tgene

ATP6V0A4

chr20:44526658

chr7:138406708

ENST00000393054

774_812

841.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for CTSA-ATP6V0A4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>20447_20447_1_CTSA-ATP6V0A4_CTSA_chr20_44526658_ENST00000191018_ATP6V0A4_chr7_138406708_ENST00000310018_length(transcript)=2209nt_BP=1429nt
CGGGCGCCTCCTGGAGAGCAAGGACGCGGGGGAGCAGAGGTGAGCTGGCACCGGAGGCTGGAGGGGATCCCCGAGCCCGGGATCGATGAT
CCGAGCCGCGCCGCCGCCGCTGTTCCTGCTGCTGCTGCTGCTGCTGCTGCTAGTGTCCTGGGCGTCCCGAGGCGAGGCAGCCCCCGACCA
GGACGAGATCCAGCGCCTCCCCGGGCTGGCCAAGCAGCCGTCTTTCCGCCAGTACTCCGGCTACCTCAAAGGCTCCGGCTCCAAGCACCT
CCACTACTGGTTTGTGGAGTCCCAGAAGGATCCCGAGAACAGCCCTGTGGTGCTTTGGCTCAATGGGGGTCCCGGCTGCAGCTCACTAGA
TGGGCTCCTCACAGAGCATGGCCCCTTCCTGGTCCAGCCAGATGGTGTCACCCTGGAGTACAACCCCTATTCTTGGAATCTGATTGCCAA
TGTGTTATACCTGGAGTCCCCAGCTGGGGTGGGCTTCTCCTACTCCGATGACAAGTTTTATGCAACTAATGACACTGAGGTCGCCCAGAG
CAATTTTGAGGCCCTTCAAGATTTCTTCCGCCTCTTTCCGGAGTACAAGAACAACAAACTTTTCCTGACCGGGGAGAGCTATGCTGGCAT
CTACATCCCCACCCTGGCCGTGCTGGTCATGCAGGATCCCAGCATGAACCTTCAGGGGCTGGCTGTGGGCAATGGACTCTCCTCCTATGA
GCAGAATGACAACTCCCTGGTCTACTTTGCCTACTACCATGGCCTTCTGGGGAACAGGCTTTGGTCTTCTCTCCAGACCCACTGCTGCTC
TCAAAACAAGTGTAACTTCTATGACAACAAAGACCTGGAATGCGTGACCAATCTTCAGGAAGTGGCCCGCATCGTGGGCAACTCTGGCCT
CAACATCTACAATCTCTATGCCCCGTGTGCTGGAGGGGTGCCCAGCCATTTTAGGTATGAGAAGGACACTGTTGTGGTCCAGGATTTGGG
CAACATCTTCACTCGCCTGCCACTCAAGCGGATGTGGCATCAGGCACTGCTGCGCTCAGGGGATAAAGTGCGCATGGACCCCCCCTGCAC
CAACACAACAGCTGCTTCCACCTACCTCAACAACCCGTACGTGCGGAAGGCCCTCAACATCCCGGAGCAGCTGCCACAATGGGACATGTG
CAACTTTCTGGTAAACTTACAGTACCGCCGTCTCTACCGAAGCATGAACTCCCAGTATCTGAAGCTGCTTAGCTCACAGAAATACCAGAT
CCTATTATATAATGGAGATGTAGACATGGCCTGCAATTTCATGGGGGATGAGTGGTTTGTGGATTCCCTCAACCAGAAGCGGCCCTGGTT
AGTGAAGTACGGGGACAGCGGGGAGCAGATTGCCGGCTTCGTGAAGGAGTTCTCCCACATCGCCTTTCTCACGATCAAGGGTTGAGTTCC
AGAACAAGTTCTATGTCGGGGATGGTTACAAGTTTTCTCCATTCTCCTTTAAACACATCCTGGATGGCACAGCCGAGGAGTAGGCTGAGG
GCTGCACCTCCCACGGTGGTCACCATGCCAATGAAGGAAGTTCAGTCTTGTCTTTGATATCAGCCCCTGCAAGGCGCTCAATGGGAAGGT
TGTTCTTGGCTCACCTGAAGCATGAAACTGTGTATTATTTGGACGTCAGCCTGTGGATTTGATACGACTTAACCACGTCAGAGGAAGGAC
TTTGGCAAGTGATATTGTCTTCATGTGGGGTATTAATTCTCAAATAATAAAGTAATTGACAAATGAGGGGAGAATGCTAAACAGATGTCT
TCTTGCAATATTTTAAATATTGTATTTGAGAAAATAAACATCTGAGTCATTCAACTGTCTGAAGTGCTCTGGACTATGGTGATGAACAGC
GGCCTTCAGACGCGAGGCTGGGGAGGAATCGTCGGGGTTTTTATTATTTTTGCCGTATTTGCTGTCCTGACAGTAGCCATCCTTCTGATC
ATGGAGGGCCTCTCTGCTTTCCTGCACGCCCTGCGACTGCACTGTTCAACTTTGGAGACGTCTTTGTCCACCAAGCCATCCACACCATCG
AGTACTGCCTGGGCTGCATTTCAAACACAGCCTCCTACCTGCGGCTCTGGGCCCTCAGCCTGGCTCATGCACTTCTAGCCGTTCTGGCCA

>20447_20447_1_CTSA-ATP6V0A4_CTSA_chr20_44526658_ENST00000191018_ATP6V0A4_chr7_138406708_ENST00000310018_length(amino acids)=449AA_BP=
MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKDPENSPVVLWLNGGPGCSS
LDGLLTEHGPFLVQPDGVTLEYNPYSWNLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYA
GIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGNS
GLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWD

--------------------------------------------------------------
>20447_20447_2_CTSA-ATP6V0A4_CTSA_chr20_44526658_ENST00000191018_ATP6V0A4_chr7_138406708_ENST00000353492_length(transcript)=1978nt_BP=1429nt
CGGGCGCCTCCTGGAGAGCAAGGACGCGGGGGAGCAGAGGTGAGCTGGCACCGGAGGCTGGAGGGGATCCCCGAGCCCGGGATCGATGAT
CCGAGCCGCGCCGCCGCCGCTGTTCCTGCTGCTGCTGCTGCTGCTGCTGCTAGTGTCCTGGGCGTCCCGAGGCGAGGCAGCCCCCGACCA
GGACGAGATCCAGCGCCTCCCCGGGCTGGCCAAGCAGCCGTCTTTCCGCCAGTACTCCGGCTACCTCAAAGGCTCCGGCTCCAAGCACCT
CCACTACTGGTTTGTGGAGTCCCAGAAGGATCCCGAGAACAGCCCTGTGGTGCTTTGGCTCAATGGGGGTCCCGGCTGCAGCTCACTAGA
TGGGCTCCTCACAGAGCATGGCCCCTTCCTGGTCCAGCCAGATGGTGTCACCCTGGAGTACAACCCCTATTCTTGGAATCTGATTGCCAA
TGTGTTATACCTGGAGTCCCCAGCTGGGGTGGGCTTCTCCTACTCCGATGACAAGTTTTATGCAACTAATGACACTGAGGTCGCCCAGAG
CAATTTTGAGGCCCTTCAAGATTTCTTCCGCCTCTTTCCGGAGTACAAGAACAACAAACTTTTCCTGACCGGGGAGAGCTATGCTGGCAT
CTACATCCCCACCCTGGCCGTGCTGGTCATGCAGGATCCCAGCATGAACCTTCAGGGGCTGGCTGTGGGCAATGGACTCTCCTCCTATGA
GCAGAATGACAACTCCCTGGTCTACTTTGCCTACTACCATGGCCTTCTGGGGAACAGGCTTTGGTCTTCTCTCCAGACCCACTGCTGCTC
TCAAAACAAGTGTAACTTCTATGACAACAAAGACCTGGAATGCGTGACCAATCTTCAGGAAGTGGCCCGCATCGTGGGCAACTCTGGCCT
CAACATCTACAATCTCTATGCCCCGTGTGCTGGAGGGGTGCCCAGCCATTTTAGGTATGAGAAGGACACTGTTGTGGTCCAGGATTTGGG
CAACATCTTCACTCGCCTGCCACTCAAGCGGATGTGGCATCAGGCACTGCTGCGCTCAGGGGATAAAGTGCGCATGGACCCCCCCTGCAC
CAACACAACAGCTGCTTCCACCTACCTCAACAACCCGTACGTGCGGAAGGCCCTCAACATCCCGGAGCAGCTGCCACAATGGGACATGTG
CAACTTTCTGGTAAACTTACAGTACCGCCGTCTCTACCGAAGCATGAACTCCCAGTATCTGAAGCTGCTTAGCTCACAGAAATACCAGAT
CCTATTATATAATGGAGATGTAGACATGGCCTGCAATTTCATGGGGGATGAGTGGTTTGTGGATTCCCTCAACCAGAAGCGGCCCTGGTT
AGTGAAGTACGGGGACAGCGGGGAGCAGATTGCCGGCTTCGTGAAGGAGTTCTCCCACATCGCCTTTCTCACGATCAAGGGTTGAGTTCC
AGAACAAGTTCTATGTCGGGGATGGTTACAAGTTTTCTCCATTCTCCTTTAAACACATCCTGGATGGCACAGCCGAGGAGTAGGCTGAGG
GCTGCACCTCCCACGGTGGTCACCATGCCAATGAAGGAAGTTCAGTCTTGTCTTTGATATCAGCCCCTGCAAGGCGCTCAATGGGAAGGT
TAACTGTCTGAAGTGCTCTGGACTATGGTGATGAACAGCGGCCTTCAGACGCGAGGCTGGGGAGGAATCGTCGGGGTTTTTATTATTTTT
GCCGTATTTGCTGTCCTGACAGTAGCCATCCTTCTGATCATGGAGGGCCTCTCTGCTTTCCTGCACGCCCTGCGACTGCACTGTTCAACT
TTGGAGACGTCTTTGTCCACCAAGCCATCCACACCATCGAGTACTGCCTGGGCTGCATTTCAAACACAGCCTCCTACCTGCGGCTCTGGG

>20447_20447_2_CTSA-ATP6V0A4_CTSA_chr20_44526658_ENST00000191018_ATP6V0A4_chr7_138406708_ENST00000353492_length(amino acids)=449AA_BP=
MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKDPENSPVVLWLNGGPGCSS
LDGLLTEHGPFLVQPDGVTLEYNPYSWNLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYA
GIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGNS
GLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWD

--------------------------------------------------------------
>20447_20447_3_CTSA-ATP6V0A4_CTSA_chr20_44526658_ENST00000191018_ATP6V0A4_chr7_138406708_ENST00000393054_length(transcript)=2209nt_BP=1429nt
CGGGCGCCTCCTGGAGAGCAAGGACGCGGGGGAGCAGAGGTGAGCTGGCACCGGAGGCTGGAGGGGATCCCCGAGCCCGGGATCGATGAT
CCGAGCCGCGCCGCCGCCGCTGTTCCTGCTGCTGCTGCTGCTGCTGCTGCTAGTGTCCTGGGCGTCCCGAGGCGAGGCAGCCCCCGACCA
GGACGAGATCCAGCGCCTCCCCGGGCTGGCCAAGCAGCCGTCTTTCCGCCAGTACTCCGGCTACCTCAAAGGCTCCGGCTCCAAGCACCT
CCACTACTGGTTTGTGGAGTCCCAGAAGGATCCCGAGAACAGCCCTGTGGTGCTTTGGCTCAATGGGGGTCCCGGCTGCAGCTCACTAGA
TGGGCTCCTCACAGAGCATGGCCCCTTCCTGGTCCAGCCAGATGGTGTCACCCTGGAGTACAACCCCTATTCTTGGAATCTGATTGCCAA
TGTGTTATACCTGGAGTCCCCAGCTGGGGTGGGCTTCTCCTACTCCGATGACAAGTTTTATGCAACTAATGACACTGAGGTCGCCCAGAG
CAATTTTGAGGCCCTTCAAGATTTCTTCCGCCTCTTTCCGGAGTACAAGAACAACAAACTTTTCCTGACCGGGGAGAGCTATGCTGGCAT
CTACATCCCCACCCTGGCCGTGCTGGTCATGCAGGATCCCAGCATGAACCTTCAGGGGCTGGCTGTGGGCAATGGACTCTCCTCCTATGA
GCAGAATGACAACTCCCTGGTCTACTTTGCCTACTACCATGGCCTTCTGGGGAACAGGCTTTGGTCTTCTCTCCAGACCCACTGCTGCTC
TCAAAACAAGTGTAACTTCTATGACAACAAAGACCTGGAATGCGTGACCAATCTTCAGGAAGTGGCCCGCATCGTGGGCAACTCTGGCCT
CAACATCTACAATCTCTATGCCCCGTGTGCTGGAGGGGTGCCCAGCCATTTTAGGTATGAGAAGGACACTGTTGTGGTCCAGGATTTGGG
CAACATCTTCACTCGCCTGCCACTCAAGCGGATGTGGCATCAGGCACTGCTGCGCTCAGGGGATAAAGTGCGCATGGACCCCCCCTGCAC
CAACACAACAGCTGCTTCCACCTACCTCAACAACCCGTACGTGCGGAAGGCCCTCAACATCCCGGAGCAGCTGCCACAATGGGACATGTG
CAACTTTCTGGTAAACTTACAGTACCGCCGTCTCTACCGAAGCATGAACTCCCAGTATCTGAAGCTGCTTAGCTCACAGAAATACCAGAT
CCTATTATATAATGGAGATGTAGACATGGCCTGCAATTTCATGGGGGATGAGTGGTTTGTGGATTCCCTCAACCAGAAGCGGCCCTGGTT
AGTGAAGTACGGGGACAGCGGGGAGCAGATTGCCGGCTTCGTGAAGGAGTTCTCCCACATCGCCTTTCTCACGATCAAGGGTTGAGTTCC
AGAACAAGTTCTATGTCGGGGATGGTTACAAGTTTTCTCCATTCTCCTTTAAACACATCCTGGATGGCACAGCCGAGGAGTAGGCTGAGG
GCTGCACCTCCCACGGTGGTCACCATGCCAATGAAGGAAGTTCAGTCTTGTCTTTGATATCAGCCCCTGCAAGGCGCTCAATGGGAAGGT
TGTTCTTGGCTCACCTGAAGCATGAAACTGTGTATTATTTGGACGTCAGCCTGTGGATTTGATACGACTTAACCACGTCAGAGGAAGGAC
TTTGGCAAGTGATATTGTCTTCATGTGGGGTATTAATTCTCAAATAATAAAGTAATTGACAAATGAGGGGAGAATGCTAAACAGATGTCT
TCTTGCAATATTTTAAATATTGTATTTGAGAAAATAAACATCTGAGTCATTCAACTGTCTGAAGTGCTCTGGACTATGGTGATGAACAGC
GGCCTTCAGACGCGAGGCTGGGGAGGAATCGTCGGGGTTTTTATTATTTTTGCCGTATTTGCTGTCCTGACAGTAGCCATCCTTCTGATC
ATGGAGGGCCTCTCTGCTTTCCTGCACGCCCTGCGACTGCACTGTTCAACTTTGGAGACGTCTTTGTCCACCAAGCCATCCACACCATCG
AGTACTGCCTGGGCTGCATTTCAAACACAGCCTCCTACCTGCGGCTCTGGGCCCTCAGCCTGGCTCATGCACTTCTAGCCGTTCTGGCCA

>20447_20447_3_CTSA-ATP6V0A4_CTSA_chr20_44526658_ENST00000191018_ATP6V0A4_chr7_138406708_ENST00000393054_length(amino acids)=449AA_BP=
MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKDPENSPVVLWLNGGPGCSS
LDGLLTEHGPFLVQPDGVTLEYNPYSWNLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYA
GIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGNS
GLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWD

--------------------------------------------------------------
>20447_20447_4_CTSA-ATP6V0A4_CTSA_chr20_44526658_ENST00000354880_ATP6V0A4_chr7_138406708_ENST00000310018_length(transcript)=2131nt_BP=1351nt
ACACATGACTTCCAGTCCCCGGGCGCCTCCTGGAGAGCAAGGACGCGGGGGAGCAGAGATGATCCGAGCCGCGCCGCCGCCGCTGTTCCT
GCTGCTGCTGCTGCTGCTGCTGCTAGTGTCCTGGGCGTCCCGAGGCGAGGCAGCCCCCGACCAGGACGAGATCCAGCGCCTCCCCGGGCT
GGCCAAGCAGCCGTCTTTCCGCCAGTACTCCGGCTACCTCAAAGGCTCCGGCTCCAAGCACCTCCACTACTGGTTTGTGGAGTCCCAGAA
GGATCCCGAGAACAGCCCTGTGGTGCTTTGGCTCAATGGGGGTCCCGGCTGCAGCTCACTAGATGGGCTCCTCACAGAGCATGGCCCCTT
CCTGATTGCCAATGTGTTATACCTGGAGTCCCCAGCTGGGGTGGGCTTCTCCTACTCCGATGACAAGTTTTATGCAACTAATGACACTGA
GGTCGCCCAGAGCAATTTTGAGGCCCTTCAAGATTTCTTCCGCCTCTTTCCGGAGTACAAGAACAACAAACTTTTCCTGACCGGGGAGAG
CTATGCTGGCATCTACATCCCCACCCTGGCCGTGCTGGTCATGCAGGATCCCAGCATGAACCTTCAGGGGCTGGCTGTGGGCAATGGACT
CTCCTCCTATGAGCAGAATGACAACTCCCTGGTCTACTTTGCCTACTACCATGGCCTTCTGGGGAACAGGCTTTGGTCTTCTCTCCAGAC
CCACTGCTGCTCTCAAAACAAGTGTAACTTCTATGACAACAAAGACCTGGAATGCGTGACCAATCTTCAGGAAGTGGCCCGCATCGTGGG
CAACTCTGGCCTCAACATCTACAATCTCTATGCCCCGTGTGCTGGAGGGGTGCCCAGCCATTTTAGGTATGAGAAGGACACTGTTGTGGT
CCAGGATTTGGGCAACATCTTCACTCGCCTGCCACTCAAGCGGATGTGGCATCAGGCACTGCTGCGCTCAGGGGATAAAGTGCGCATGGA
CCCCCCCTGCACCAACACAACAGCTGCTTCCACCTACCTCAACAACCCGTACGTGCGGAAGGCCCTCAACATCCCGGAGCAGCTGCCACA
ATGGGACATGTGCAACTTTCTGGTAAACTTACAGTACCGCCGTCTCTACCGAAGCATGAACTCCCAGTATCTGAAGCTGCTTAGCTCACA
GAAATACCAGATCCTATTATATAATGGAGATGTAGACATGGCCTGCAATTTCATGGGGGATGAGTGGTTTGTGGATTCCCTCAACCAGAA
GCGGCCCTGGTTAGTGAAGTACGGGGACAGCGGGGAGCAGATTGCCGGCTTCGTGAAGGAGTTCTCCCACATCGCCTTTCTCACGATCAA
GGGTTGAGTTCCAGAACAAGTTCTATGTCGGGGATGGTTACAAGTTTTCTCCATTCTCCTTTAAACACATCCTGGATGGCACAGCCGAGG
AGTAGGCTGAGGGCTGCACCTCCCACGGTGGTCACCATGCCAATGAAGGAAGTTCAGTCTTGTCTTTGATATCAGCCCCTGCAAGGCGCT
CAATGGGAAGGTTGTTCTTGGCTCACCTGAAGCATGAAACTGTGTATTATTTGGACGTCAGCCTGTGGATTTGATACGACTTAACCACGT
CAGAGGAAGGACTTTGGCAAGTGATATTGTCTTCATGTGGGGTATTAATTCTCAAATAATAAAGTAATTGACAAATGAGGGGAGAATGCT
AAACAGATGTCTTCTTGCAATATTTTAAATATTGTATTTGAGAAAATAAACATCTGAGTCATTCAACTGTCTGAAGTGCTCTGGACTATG
GTGATGAACAGCGGCCTTCAGACGCGAGGCTGGGGAGGAATCGTCGGGGTTTTTATTATTTTTGCCGTATTTGCTGTCCTGACAGTAGCC
ATCCTTCTGATCATGGAGGGCCTCTCTGCTTTCCTGCACGCCCTGCGACTGCACTGTTCAACTTTGGAGACGTCTTTGTCCACCAAGCCA
TCCACACCATCGAGTACTGCCTGGGCTGCATTTCAAACACAGCCTCCTACCTGCGGCTCTGGGCCCTCAGCCTGGCTCATGCACTTCTAG

>20447_20447_4_CTSA-ATP6V0A4_CTSA_chr20_44526658_ENST00000354880_ATP6V0A4_chr7_138406708_ENST00000310018_length(amino acids)=450AA_BP=
MTSSPRAPPGEQGRGGAEMIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKD
PENSPVVLWLNGGPGCSSLDGLLTEHGPFLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESY
AGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGN
SGLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQW
DMCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKG

--------------------------------------------------------------
>20447_20447_5_CTSA-ATP6V0A4_CTSA_chr20_44526658_ENST00000354880_ATP6V0A4_chr7_138406708_ENST00000353492_length(transcript)=1900nt_BP=1351nt
ACACATGACTTCCAGTCCCCGGGCGCCTCCTGGAGAGCAAGGACGCGGGGGAGCAGAGATGATCCGAGCCGCGCCGCCGCCGCTGTTCCT
GCTGCTGCTGCTGCTGCTGCTGCTAGTGTCCTGGGCGTCCCGAGGCGAGGCAGCCCCCGACCAGGACGAGATCCAGCGCCTCCCCGGGCT
GGCCAAGCAGCCGTCTTTCCGCCAGTACTCCGGCTACCTCAAAGGCTCCGGCTCCAAGCACCTCCACTACTGGTTTGTGGAGTCCCAGAA
GGATCCCGAGAACAGCCCTGTGGTGCTTTGGCTCAATGGGGGTCCCGGCTGCAGCTCACTAGATGGGCTCCTCACAGAGCATGGCCCCTT
CCTGATTGCCAATGTGTTATACCTGGAGTCCCCAGCTGGGGTGGGCTTCTCCTACTCCGATGACAAGTTTTATGCAACTAATGACACTGA
GGTCGCCCAGAGCAATTTTGAGGCCCTTCAAGATTTCTTCCGCCTCTTTCCGGAGTACAAGAACAACAAACTTTTCCTGACCGGGGAGAG
CTATGCTGGCATCTACATCCCCACCCTGGCCGTGCTGGTCATGCAGGATCCCAGCATGAACCTTCAGGGGCTGGCTGTGGGCAATGGACT
CTCCTCCTATGAGCAGAATGACAACTCCCTGGTCTACTTTGCCTACTACCATGGCCTTCTGGGGAACAGGCTTTGGTCTTCTCTCCAGAC
CCACTGCTGCTCTCAAAACAAGTGTAACTTCTATGACAACAAAGACCTGGAATGCGTGACCAATCTTCAGGAAGTGGCCCGCATCGTGGG
CAACTCTGGCCTCAACATCTACAATCTCTATGCCCCGTGTGCTGGAGGGGTGCCCAGCCATTTTAGGTATGAGAAGGACACTGTTGTGGT
CCAGGATTTGGGCAACATCTTCACTCGCCTGCCACTCAAGCGGATGTGGCATCAGGCACTGCTGCGCTCAGGGGATAAAGTGCGCATGGA
CCCCCCCTGCACCAACACAACAGCTGCTTCCACCTACCTCAACAACCCGTACGTGCGGAAGGCCCTCAACATCCCGGAGCAGCTGCCACA
ATGGGACATGTGCAACTTTCTGGTAAACTTACAGTACCGCCGTCTCTACCGAAGCATGAACTCCCAGTATCTGAAGCTGCTTAGCTCACA
GAAATACCAGATCCTATTATATAATGGAGATGTAGACATGGCCTGCAATTTCATGGGGGATGAGTGGTTTGTGGATTCCCTCAACCAGAA
GCGGCCCTGGTTAGTGAAGTACGGGGACAGCGGGGAGCAGATTGCCGGCTTCGTGAAGGAGTTCTCCCACATCGCCTTTCTCACGATCAA
GGGTTGAGTTCCAGAACAAGTTCTATGTCGGGGATGGTTACAAGTTTTCTCCATTCTCCTTTAAACACATCCTGGATGGCACAGCCGAGG
AGTAGGCTGAGGGCTGCACCTCCCACGGTGGTCACCATGCCAATGAAGGAAGTTCAGTCTTGTCTTTGATATCAGCCCCTGCAAGGCGCT
CAATGGGAAGGTTAACTGTCTGAAGTGCTCTGGACTATGGTGATGAACAGCGGCCTTCAGACGCGAGGCTGGGGAGGAATCGTCGGGGTT
TTTATTATTTTTGCCGTATTTGCTGTCCTGACAGTAGCCATCCTTCTGATCATGGAGGGCCTCTCTGCTTTCCTGCACGCCCTGCGACTG
CACTGTTCAACTTTGGAGACGTCTTTGTCCACCAAGCCATCCACACCATCGAGTACTGCCTGGGCTGCATTTCAAACACAGCCTCCTACC
TGCGGCTCTGGGCCCTCAGCCTGGCTCATGCACTTCTAGCCGTTCTGGCCAGAGGACTTCTGCAGATACCCACGGGGCTCTGGACGACCA

>20447_20447_5_CTSA-ATP6V0A4_CTSA_chr20_44526658_ENST00000354880_ATP6V0A4_chr7_138406708_ENST00000353492_length(amino acids)=450AA_BP=
MTSSPRAPPGEQGRGGAEMIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKD
PENSPVVLWLNGGPGCSSLDGLLTEHGPFLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESY
AGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGN
SGLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQW
DMCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKG

--------------------------------------------------------------
>20447_20447_6_CTSA-ATP6V0A4_CTSA_chr20_44526658_ENST00000354880_ATP6V0A4_chr7_138406708_ENST00000393054_length(transcript)=2131nt_BP=1351nt
ACACATGACTTCCAGTCCCCGGGCGCCTCCTGGAGAGCAAGGACGCGGGGGAGCAGAGATGATCCGAGCCGCGCCGCCGCCGCTGTTCCT
GCTGCTGCTGCTGCTGCTGCTGCTAGTGTCCTGGGCGTCCCGAGGCGAGGCAGCCCCCGACCAGGACGAGATCCAGCGCCTCCCCGGGCT
GGCCAAGCAGCCGTCTTTCCGCCAGTACTCCGGCTACCTCAAAGGCTCCGGCTCCAAGCACCTCCACTACTGGTTTGTGGAGTCCCAGAA
GGATCCCGAGAACAGCCCTGTGGTGCTTTGGCTCAATGGGGGTCCCGGCTGCAGCTCACTAGATGGGCTCCTCACAGAGCATGGCCCCTT
CCTGATTGCCAATGTGTTATACCTGGAGTCCCCAGCTGGGGTGGGCTTCTCCTACTCCGATGACAAGTTTTATGCAACTAATGACACTGA
GGTCGCCCAGAGCAATTTTGAGGCCCTTCAAGATTTCTTCCGCCTCTTTCCGGAGTACAAGAACAACAAACTTTTCCTGACCGGGGAGAG
CTATGCTGGCATCTACATCCCCACCCTGGCCGTGCTGGTCATGCAGGATCCCAGCATGAACCTTCAGGGGCTGGCTGTGGGCAATGGACT
CTCCTCCTATGAGCAGAATGACAACTCCCTGGTCTACTTTGCCTACTACCATGGCCTTCTGGGGAACAGGCTTTGGTCTTCTCTCCAGAC
CCACTGCTGCTCTCAAAACAAGTGTAACTTCTATGACAACAAAGACCTGGAATGCGTGACCAATCTTCAGGAAGTGGCCCGCATCGTGGG
CAACTCTGGCCTCAACATCTACAATCTCTATGCCCCGTGTGCTGGAGGGGTGCCCAGCCATTTTAGGTATGAGAAGGACACTGTTGTGGT
CCAGGATTTGGGCAACATCTTCACTCGCCTGCCACTCAAGCGGATGTGGCATCAGGCACTGCTGCGCTCAGGGGATAAAGTGCGCATGGA
CCCCCCCTGCACCAACACAACAGCTGCTTCCACCTACCTCAACAACCCGTACGTGCGGAAGGCCCTCAACATCCCGGAGCAGCTGCCACA
ATGGGACATGTGCAACTTTCTGGTAAACTTACAGTACCGCCGTCTCTACCGAAGCATGAACTCCCAGTATCTGAAGCTGCTTAGCTCACA
GAAATACCAGATCCTATTATATAATGGAGATGTAGACATGGCCTGCAATTTCATGGGGGATGAGTGGTTTGTGGATTCCCTCAACCAGAA
GCGGCCCTGGTTAGTGAAGTACGGGGACAGCGGGGAGCAGATTGCCGGCTTCGTGAAGGAGTTCTCCCACATCGCCTTTCTCACGATCAA
GGGTTGAGTTCCAGAACAAGTTCTATGTCGGGGATGGTTACAAGTTTTCTCCATTCTCCTTTAAACACATCCTGGATGGCACAGCCGAGG
AGTAGGCTGAGGGCTGCACCTCCCACGGTGGTCACCATGCCAATGAAGGAAGTTCAGTCTTGTCTTTGATATCAGCCCCTGCAAGGCGCT
CAATGGGAAGGTTGTTCTTGGCTCACCTGAAGCATGAAACTGTGTATTATTTGGACGTCAGCCTGTGGATTTGATACGACTTAACCACGT
CAGAGGAAGGACTTTGGCAAGTGATATTGTCTTCATGTGGGGTATTAATTCTCAAATAATAAAGTAATTGACAAATGAGGGGAGAATGCT
AAACAGATGTCTTCTTGCAATATTTTAAATATTGTATTTGAGAAAATAAACATCTGAGTCATTCAACTGTCTGAAGTGCTCTGGACTATG
GTGATGAACAGCGGCCTTCAGACGCGAGGCTGGGGAGGAATCGTCGGGGTTTTTATTATTTTTGCCGTATTTGCTGTCCTGACAGTAGCC
ATCCTTCTGATCATGGAGGGCCTCTCTGCTTTCCTGCACGCCCTGCGACTGCACTGTTCAACTTTGGAGACGTCTTTGTCCACCAAGCCA
TCCACACCATCGAGTACTGCCTGGGCTGCATTTCAAACACAGCCTCCTACCTGCGGCTCTGGGCCCTCAGCCTGGCTCATGCACTTCTAG

>20447_20447_6_CTSA-ATP6V0A4_CTSA_chr20_44526658_ENST00000354880_ATP6V0A4_chr7_138406708_ENST00000393054_length(amino acids)=450AA_BP=
MTSSPRAPPGEQGRGGAEMIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKD
PENSPVVLWLNGGPGCSSLDGLLTEHGPFLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESY
AGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGN
SGLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQW
DMCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKG

--------------------------------------------------------------
>20447_20447_7_CTSA-ATP6V0A4_CTSA_chr20_44526658_ENST00000372459_ATP6V0A4_chr7_138406708_ENST00000310018_length(transcript)=2317nt_BP=1537nt
AGAGGTGAGCTGGCACCGGAGGCTGGAGGGGATCCCCGAGCCCGGGATCGGTGCGCGGCAGAGGAGGCTCGCGGGTGGGAGCTGGCGCTG
GGGCCGGGGCTTCCCTCGCGGAGGCGCCGCCAGCAACTCCCCGGGGGCTGCTGCACGGAAGCGCTGAGGAGCGAGTCAACAGCCCCTCTG
CTGCCTCCCGTAGATGATCCGAGCCGCGCCGCCGCCGCTGTTCCTGCTGCTGCTGCTGCTGCTGCTGCTAGTGTCCTGGGCGTCCCGAGG
CGAGGCAGCCCCCGACCAGGACGAGATCCAGCGCCTCCCCGGGCTGGCCAAGCAGCCGTCTTTCCGCCAGTACTCCGGCTACCTCAAAGG
CTCCGGCTCCAAGCACCTCCACTACTGGTTTGTGGAGTCCCAGAAGGATCCCGAGAACAGCCCTGTGGTGCTTTGGCTCAATGGGGGTCC
CGGCTGCAGCTCACTAGATGGGCTCCTCACAGAGCATGGCCCCTTCCTGGTCCAGCCAGATGGTGTCACCCTGGAGTACAACCCCTATTC
TTGGAATCTGATTGCCAATGTGTTATACCTGGAGTCCCCAGCTGGGGTGGGCTTCTCCTACTCCGATGACAAGTTTTATGCAACTAATGA
CACTGAGGTCGCCCAGAGCAATTTTGAGGCCCTTCAAGATTTCTTCCGCCTCTTTCCGGAGTACAAGAACAACAAACTTTTCCTGACCGG
GGAGAGCTATGCTGGCATCTACATCCCCACCCTGGCCGTGCTGGTCATGCAGGATCCCAGCATGAACCTTCAGGGGCTGGCTGTGGGCAA
TGGACTCTCCTCCTATGAGCAGAATGACAACTCCCTGGTCTACTTTGCCTACTACCATGGCCTTCTGGGGAACAGGCTTTGGTCTTCTCT
CCAGACCCACTGCTGCTCTCAAAACAAGTGTAACTTCTATGACAACAAAGACCTGGAATGCGTGACCAATCTTCAGGAAGTGGCCCGCAT
CGTGGGCAACTCTGGCCTCAACATCTACAATCTCTATGCCCCGTGTGCTGGAGGGGTGCCCAGCCATTTTAGGTATGAGAAGGACACTGT
TGTGGTCCAGGATTTGGGCAACATCTTCACTCGCCTGCCACTCAAGCGGATGTGGCATCAGGCACTGCTGCGCTCAGGGGATAAAGTGCG
CATGGACCCCCCCTGCACCAACACAACAGCTGCTTCCACCTACCTCAACAACCCGTACGTGCGGAAGGCCCTCAACATCCCGGAGCAGCT
GCCACAATGGGACATGTGCAACTTTCTGGTAAACTTACAGTACCGCCGTCTCTACCGAAGCATGAACTCCCAGTATCTGAAGCTGCTTAG
CTCACAGAAATACCAGATCCTATTATATAATGGAGATGTAGACATGGCCTGCAATTTCATGGGGGATGAGTGGTTTGTGGATTCCCTCAA
CCAGAAGCGGCCCTGGTTAGTGAAGTACGGGGACAGCGGGGAGCAGATTGCCGGCTTCGTGAAGGAGTTCTCCCACATCGCCTTTCTCAC
GATCAAGGGTTGAGTTCCAGAACAAGTTCTATGTCGGGGATGGTTACAAGTTTTCTCCATTCTCCTTTAAACACATCCTGGATGGCACAG
CCGAGGAGTAGGCTGAGGGCTGCACCTCCCACGGTGGTCACCATGCCAATGAAGGAAGTTCAGTCTTGTCTTTGATATCAGCCCCTGCAA
GGCGCTCAATGGGAAGGTTGTTCTTGGCTCACCTGAAGCATGAAACTGTGTATTATTTGGACGTCAGCCTGTGGATTTGATACGACTTAA
CCACGTCAGAGGAAGGACTTTGGCAAGTGATATTGTCTTCATGTGGGGTATTAATTCTCAAATAATAAAGTAATTGACAAATGAGGGGAG
AATGCTAAACAGATGTCTTCTTGCAATATTTTAAATATTGTATTTGAGAAAATAAACATCTGAGTCATTCAACTGTCTGAAGTGCTCTGG
ACTATGGTGATGAACAGCGGCCTTCAGACGCGAGGCTGGGGAGGAATCGTCGGGGTTTTTATTATTTTTGCCGTATTTGCTGTCCTGACA
GTAGCCATCCTTCTGATCATGGAGGGCCTCTCTGCTTTCCTGCACGCCCTGCGACTGCACTGTTCAACTTTGGAGACGTCTTTGTCCACC
AAGCCATCCACACCATCGAGTACTGCCTGGGCTGCATTTCAAACACAGCCTCCTACCTGCGGCTCTGGGCCCTCAGCCTGGCTCATGCAC

>20447_20447_7_CTSA-ATP6V0A4_CTSA_chr20_44526658_ENST00000372459_ATP6V0A4_chr7_138406708_ENST00000310018_length(amino acids)=449AA_BP=
MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKDPENSPVVLWLNGGPGCSS
LDGLLTEHGPFLVQPDGVTLEYNPYSWNLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYA
GIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGNS
GLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWD

--------------------------------------------------------------
>20447_20447_8_CTSA-ATP6V0A4_CTSA_chr20_44526658_ENST00000372459_ATP6V0A4_chr7_138406708_ENST00000353492_length(transcript)=2086nt_BP=1537nt
AGAGGTGAGCTGGCACCGGAGGCTGGAGGGGATCCCCGAGCCCGGGATCGGTGCGCGGCAGAGGAGGCTCGCGGGTGGGAGCTGGCGCTG
GGGCCGGGGCTTCCCTCGCGGAGGCGCCGCCAGCAACTCCCCGGGGGCTGCTGCACGGAAGCGCTGAGGAGCGAGTCAACAGCCCCTCTG
CTGCCTCCCGTAGATGATCCGAGCCGCGCCGCCGCCGCTGTTCCTGCTGCTGCTGCTGCTGCTGCTGCTAGTGTCCTGGGCGTCCCGAGG
CGAGGCAGCCCCCGACCAGGACGAGATCCAGCGCCTCCCCGGGCTGGCCAAGCAGCCGTCTTTCCGCCAGTACTCCGGCTACCTCAAAGG
CTCCGGCTCCAAGCACCTCCACTACTGGTTTGTGGAGTCCCAGAAGGATCCCGAGAACAGCCCTGTGGTGCTTTGGCTCAATGGGGGTCC
CGGCTGCAGCTCACTAGATGGGCTCCTCACAGAGCATGGCCCCTTCCTGGTCCAGCCAGATGGTGTCACCCTGGAGTACAACCCCTATTC
TTGGAATCTGATTGCCAATGTGTTATACCTGGAGTCCCCAGCTGGGGTGGGCTTCTCCTACTCCGATGACAAGTTTTATGCAACTAATGA
CACTGAGGTCGCCCAGAGCAATTTTGAGGCCCTTCAAGATTTCTTCCGCCTCTTTCCGGAGTACAAGAACAACAAACTTTTCCTGACCGG
GGAGAGCTATGCTGGCATCTACATCCCCACCCTGGCCGTGCTGGTCATGCAGGATCCCAGCATGAACCTTCAGGGGCTGGCTGTGGGCAA
TGGACTCTCCTCCTATGAGCAGAATGACAACTCCCTGGTCTACTTTGCCTACTACCATGGCCTTCTGGGGAACAGGCTTTGGTCTTCTCT
CCAGACCCACTGCTGCTCTCAAAACAAGTGTAACTTCTATGACAACAAAGACCTGGAATGCGTGACCAATCTTCAGGAAGTGGCCCGCAT
CGTGGGCAACTCTGGCCTCAACATCTACAATCTCTATGCCCCGTGTGCTGGAGGGGTGCCCAGCCATTTTAGGTATGAGAAGGACACTGT
TGTGGTCCAGGATTTGGGCAACATCTTCACTCGCCTGCCACTCAAGCGGATGTGGCATCAGGCACTGCTGCGCTCAGGGGATAAAGTGCG
CATGGACCCCCCCTGCACCAACACAACAGCTGCTTCCACCTACCTCAACAACCCGTACGTGCGGAAGGCCCTCAACATCCCGGAGCAGCT
GCCACAATGGGACATGTGCAACTTTCTGGTAAACTTACAGTACCGCCGTCTCTACCGAAGCATGAACTCCCAGTATCTGAAGCTGCTTAG
CTCACAGAAATACCAGATCCTATTATATAATGGAGATGTAGACATGGCCTGCAATTTCATGGGGGATGAGTGGTTTGTGGATTCCCTCAA
CCAGAAGCGGCCCTGGTTAGTGAAGTACGGGGACAGCGGGGAGCAGATTGCCGGCTTCGTGAAGGAGTTCTCCCACATCGCCTTTCTCAC
GATCAAGGGTTGAGTTCCAGAACAAGTTCTATGTCGGGGATGGTTACAAGTTTTCTCCATTCTCCTTTAAACACATCCTGGATGGCACAG
CCGAGGAGTAGGCTGAGGGCTGCACCTCCCACGGTGGTCACCATGCCAATGAAGGAAGTTCAGTCTTGTCTTTGATATCAGCCCCTGCAA
GGCGCTCAATGGGAAGGTTAACTGTCTGAAGTGCTCTGGACTATGGTGATGAACAGCGGCCTTCAGACGCGAGGCTGGGGAGGAATCGTC
GGGGTTTTTATTATTTTTGCCGTATTTGCTGTCCTGACAGTAGCCATCCTTCTGATCATGGAGGGCCTCTCTGCTTTCCTGCACGCCCTG
CGACTGCACTGTTCAACTTTGGAGACGTCTTTGTCCACCAAGCCATCCACACCATCGAGTACTGCCTGGGCTGCATTTCAAACACAGCCT
CCTACCTGCGGCTCTGGGCCCTCAGCCTGGCTCATGCACTTCTAGCCGTTCTGGCCAGAGGACTTCTGCAGATACCCACGGGGCTCTGGA

>20447_20447_8_CTSA-ATP6V0A4_CTSA_chr20_44526658_ENST00000372459_ATP6V0A4_chr7_138406708_ENST00000353492_length(amino acids)=449AA_BP=
MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKDPENSPVVLWLNGGPGCSS
LDGLLTEHGPFLVQPDGVTLEYNPYSWNLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYA
GIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGNS
GLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWD

--------------------------------------------------------------
>20447_20447_9_CTSA-ATP6V0A4_CTSA_chr20_44526658_ENST00000372459_ATP6V0A4_chr7_138406708_ENST00000393054_length(transcript)=2317nt_BP=1537nt
AGAGGTGAGCTGGCACCGGAGGCTGGAGGGGATCCCCGAGCCCGGGATCGGTGCGCGGCAGAGGAGGCTCGCGGGTGGGAGCTGGCGCTG
GGGCCGGGGCTTCCCTCGCGGAGGCGCCGCCAGCAACTCCCCGGGGGCTGCTGCACGGAAGCGCTGAGGAGCGAGTCAACAGCCCCTCTG
CTGCCTCCCGTAGATGATCCGAGCCGCGCCGCCGCCGCTGTTCCTGCTGCTGCTGCTGCTGCTGCTGCTAGTGTCCTGGGCGTCCCGAGG
CGAGGCAGCCCCCGACCAGGACGAGATCCAGCGCCTCCCCGGGCTGGCCAAGCAGCCGTCTTTCCGCCAGTACTCCGGCTACCTCAAAGG
CTCCGGCTCCAAGCACCTCCACTACTGGTTTGTGGAGTCCCAGAAGGATCCCGAGAACAGCCCTGTGGTGCTTTGGCTCAATGGGGGTCC
CGGCTGCAGCTCACTAGATGGGCTCCTCACAGAGCATGGCCCCTTCCTGGTCCAGCCAGATGGTGTCACCCTGGAGTACAACCCCTATTC
TTGGAATCTGATTGCCAATGTGTTATACCTGGAGTCCCCAGCTGGGGTGGGCTTCTCCTACTCCGATGACAAGTTTTATGCAACTAATGA
CACTGAGGTCGCCCAGAGCAATTTTGAGGCCCTTCAAGATTTCTTCCGCCTCTTTCCGGAGTACAAGAACAACAAACTTTTCCTGACCGG
GGAGAGCTATGCTGGCATCTACATCCCCACCCTGGCCGTGCTGGTCATGCAGGATCCCAGCATGAACCTTCAGGGGCTGGCTGTGGGCAA
TGGACTCTCCTCCTATGAGCAGAATGACAACTCCCTGGTCTACTTTGCCTACTACCATGGCCTTCTGGGGAACAGGCTTTGGTCTTCTCT
CCAGACCCACTGCTGCTCTCAAAACAAGTGTAACTTCTATGACAACAAAGACCTGGAATGCGTGACCAATCTTCAGGAAGTGGCCCGCAT
CGTGGGCAACTCTGGCCTCAACATCTACAATCTCTATGCCCCGTGTGCTGGAGGGGTGCCCAGCCATTTTAGGTATGAGAAGGACACTGT
TGTGGTCCAGGATTTGGGCAACATCTTCACTCGCCTGCCACTCAAGCGGATGTGGCATCAGGCACTGCTGCGCTCAGGGGATAAAGTGCG
CATGGACCCCCCCTGCACCAACACAACAGCTGCTTCCACCTACCTCAACAACCCGTACGTGCGGAAGGCCCTCAACATCCCGGAGCAGCT
GCCACAATGGGACATGTGCAACTTTCTGGTAAACTTACAGTACCGCCGTCTCTACCGAAGCATGAACTCCCAGTATCTGAAGCTGCTTAG
CTCACAGAAATACCAGATCCTATTATATAATGGAGATGTAGACATGGCCTGCAATTTCATGGGGGATGAGTGGTTTGTGGATTCCCTCAA
CCAGAAGCGGCCCTGGTTAGTGAAGTACGGGGACAGCGGGGAGCAGATTGCCGGCTTCGTGAAGGAGTTCTCCCACATCGCCTTTCTCAC
GATCAAGGGTTGAGTTCCAGAACAAGTTCTATGTCGGGGATGGTTACAAGTTTTCTCCATTCTCCTTTAAACACATCCTGGATGGCACAG
CCGAGGAGTAGGCTGAGGGCTGCACCTCCCACGGTGGTCACCATGCCAATGAAGGAAGTTCAGTCTTGTCTTTGATATCAGCCCCTGCAA
GGCGCTCAATGGGAAGGTTGTTCTTGGCTCACCTGAAGCATGAAACTGTGTATTATTTGGACGTCAGCCTGTGGATTTGATACGACTTAA
CCACGTCAGAGGAAGGACTTTGGCAAGTGATATTGTCTTCATGTGGGGTATTAATTCTCAAATAATAAAGTAATTGACAAATGAGGGGAG
AATGCTAAACAGATGTCTTCTTGCAATATTTTAAATATTGTATTTGAGAAAATAAACATCTGAGTCATTCAACTGTCTGAAGTGCTCTGG
ACTATGGTGATGAACAGCGGCCTTCAGACGCGAGGCTGGGGAGGAATCGTCGGGGTTTTTATTATTTTTGCCGTATTTGCTGTCCTGACA
GTAGCCATCCTTCTGATCATGGAGGGCCTCTCTGCTTTCCTGCACGCCCTGCGACTGCACTGTTCAACTTTGGAGACGTCTTTGTCCACC
AAGCCATCCACACCATCGAGTACTGCCTGGGCTGCATTTCAAACACAGCCTCCTACCTGCGGCTCTGGGCCCTCAGCCTGGCTCATGCAC

>20447_20447_9_CTSA-ATP6V0A4_CTSA_chr20_44526658_ENST00000372459_ATP6V0A4_chr7_138406708_ENST00000393054_length(amino acids)=449AA_BP=
MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKDPENSPVVLWLNGGPGCSS
LDGLLTEHGPFLVQPDGVTLEYNPYSWNLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYA
GIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGNS
GLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWD

--------------------------------------------------------------
>20447_20447_10_CTSA-ATP6V0A4_CTSA_chr20_44526658_ENST00000372484_ATP6V0A4_chr7_138406708_ENST00000310018_length(transcript)=2460nt_BP=1680nt
GCAATGATGGTGACCGCAAGGCGACCTTGTAAGGCATTTCCCCCCTGACTCCCTTCCCCGAGCCTCTGCCCGGGGGTCCTAGCGCCGCTT
TCTCAGCCATCCCGCCTACAACTTAGCCGTCCACAACAGGATCATCTGATCGCGTGCGCCCGGGCTACGATCTGCGAGGCCCGCGGACCT
TGACCCGGCATTGACCGCCACCGCCCCCCAGGTCCGTAGGGACCAAAGAAGGGGCGGGAGGAAGACTGTCACGTGGCGCCGGAGTTCACG
TGACTCGTACACATGACTTCCAGTCCCCGGGCGCCTCCTGGAGAGCAAGGACGCGGGGGAGCAGAGATGATCCGAGCCGCGCCGCCGCCG
CTGTTCCTGCTGCTGCTGCTGCTGCTGCTGCTAGTGTCCTGGGCGTCCCGAGGCGAGGCAGCCCCCGACCAGGACGAGATCCAGCGCCTC
CCCGGGCTGGCCAAGCAGCCGTCTTTCCGCCAGTACTCCGGCTACCTCAAAGGCTCCGGCTCCAAGCACCTCCACTACTGGTTTGTGGAG
TCCCAGAAGGATCCCGAGAACAGCCCTGTGGTGCTTTGGCTCAATGGGGGTCCCGGCTGCAGCTCACTAGATGGGCTCCTCACAGAGCAT
GGCCCCTTCCTGGTCCAGCCAGATGGTGTCACCCTGGAGTACAACCCCTATTCTTGGAATCTGATTGCCAATGTGTTATACCTGGAGTCC
CCAGCTGGGGTGGGCTTCTCCTACTCCGATGACAAGTTTTATGCAACTAATGACACTGAGGTCGCCCAGAGCAATTTTGAGGCCCTTCAA
GATTTCTTCCGCCTCTTTCCGGAGTACAAGAACAACAAACTTTTCCTGACCGGGGAGAGCTATGCTGGCATCTACATCCCCACCCTGGCC
GTGCTGGTCATGCAGGATCCCAGCATGAACCTTCAGGGGCTGGCTGTGGGCAATGGACTCTCCTCCTATGAGCAGAATGACAACTCCCTG
GTCTACTTTGCCTACTACCATGGCCTTCTGGGGAACAGGCTTTGGTCTTCTCTCCAGACCCACTGCTGCTCTCAAAACAAGTGTAACTTC
TATGACAACAAAGACCTGGAATGCGTGACCAATCTTCAGGAAGTGGCCCGCATCGTGGGCAACTCTGGCCTCAACATCTACAATCTCTAT
GCCCCGTGTGCTGGAGGGGTGCCCAGCCATTTTAGGTATGAGAAGGACACTGTTGTGGTCCAGGATTTGGGCAACATCTTCACTCGCCTG
CCACTCAAGCGGATGTGGCATCAGGCACTGCTGCGCTCAGGGGATAAAGTGCGCATGGACCCCCCCTGCACCAACACAACAGCTGCTTCC
ACCTACCTCAACAACCCGTACGTGCGGAAGGCCCTCAACATCCCGGAGCAGCTGCCACAATGGGACATGTGCAACTTTCTGGTAAACTTA
CAGTACCGCCGTCTCTACCGAAGCATGAACTCCCAGTATCTGAAGCTGCTTAGCTCACAGAAATACCAGATCCTATTATATAATGGAGAT
GTAGACATGGCCTGCAATTTCATGGGGGATGAGTGGTTTGTGGATTCCCTCAACCAGAAGCGGCCCTGGTTAGTGAAGTACGGGGACAGC
GGGGAGCAGATTGCCGGCTTCGTGAAGGAGTTCTCCCACATCGCCTTTCTCACGATCAAGGGTTGAGTTCCAGAACAAGTTCTATGTCGG
GGATGGTTACAAGTTTTCTCCATTCTCCTTTAAACACATCCTGGATGGCACAGCCGAGGAGTAGGCTGAGGGCTGCACCTCCCACGGTGG
TCACCATGCCAATGAAGGAAGTTCAGTCTTGTCTTTGATATCAGCCCCTGCAAGGCGCTCAATGGGAAGGTTGTTCTTGGCTCACCTGAA
GCATGAAACTGTGTATTATTTGGACGTCAGCCTGTGGATTTGATACGACTTAACCACGTCAGAGGAAGGACTTTGGCAAGTGATATTGTC
TTCATGTGGGGTATTAATTCTCAAATAATAAAGTAATTGACAAATGAGGGGAGAATGCTAAACAGATGTCTTCTTGCAATATTTTAAATA
TTGTATTTGAGAAAATAAACATCTGAGTCATTCAACTGTCTGAAGTGCTCTGGACTATGGTGATGAACAGCGGCCTTCAGACGCGAGGCT
GGGGAGGAATCGTCGGGGTTTTTATTATTTTTGCCGTATTTGCTGTCCTGACAGTAGCCATCCTTCTGATCATGGAGGGCCTCTCTGCTT
TCCTGCACGCCCTGCGACTGCACTGTTCAACTTTGGAGACGTCTTTGTCCACCAAGCCATCCACACCATCGAGTACTGCCTGGGCTGCAT
TTCAAACACAGCCTCCTACCTGCGGCTCTGGGCCCTCAGCCTGGCTCATGCACTTCTAGCCGTTCTGGCCAGAGGACTTCTGCAGATACC

>20447_20447_10_CTSA-ATP6V0A4_CTSA_chr20_44526658_ENST00000372484_ATP6V0A4_chr7_138406708_ENST00000310018_length(amino acids)=467AA_BP=
MTSSPRAPPGEQGRGGAEMIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKD
PENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFR
LFPEYKNNKLFLTGESYAGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNK
DLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLN
NPYVRKALNIPEQLPQWDMCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKRPWLVKYGDSGEQI

--------------------------------------------------------------
>20447_20447_11_CTSA-ATP6V0A4_CTSA_chr20_44526658_ENST00000372484_ATP6V0A4_chr7_138406708_ENST00000353492_length(transcript)=2229nt_BP=1680nt
GCAATGATGGTGACCGCAAGGCGACCTTGTAAGGCATTTCCCCCCTGACTCCCTTCCCCGAGCCTCTGCCCGGGGGTCCTAGCGCCGCTT
TCTCAGCCATCCCGCCTACAACTTAGCCGTCCACAACAGGATCATCTGATCGCGTGCGCCCGGGCTACGATCTGCGAGGCCCGCGGACCT
TGACCCGGCATTGACCGCCACCGCCCCCCAGGTCCGTAGGGACCAAAGAAGGGGCGGGAGGAAGACTGTCACGTGGCGCCGGAGTTCACG
TGACTCGTACACATGACTTCCAGTCCCCGGGCGCCTCCTGGAGAGCAAGGACGCGGGGGAGCAGAGATGATCCGAGCCGCGCCGCCGCCG
CTGTTCCTGCTGCTGCTGCTGCTGCTGCTGCTAGTGTCCTGGGCGTCCCGAGGCGAGGCAGCCCCCGACCAGGACGAGATCCAGCGCCTC
CCCGGGCTGGCCAAGCAGCCGTCTTTCCGCCAGTACTCCGGCTACCTCAAAGGCTCCGGCTCCAAGCACCTCCACTACTGGTTTGTGGAG
TCCCAGAAGGATCCCGAGAACAGCCCTGTGGTGCTTTGGCTCAATGGGGGTCCCGGCTGCAGCTCACTAGATGGGCTCCTCACAGAGCAT
GGCCCCTTCCTGGTCCAGCCAGATGGTGTCACCCTGGAGTACAACCCCTATTCTTGGAATCTGATTGCCAATGTGTTATACCTGGAGTCC
CCAGCTGGGGTGGGCTTCTCCTACTCCGATGACAAGTTTTATGCAACTAATGACACTGAGGTCGCCCAGAGCAATTTTGAGGCCCTTCAA
GATTTCTTCCGCCTCTTTCCGGAGTACAAGAACAACAAACTTTTCCTGACCGGGGAGAGCTATGCTGGCATCTACATCCCCACCCTGGCC
GTGCTGGTCATGCAGGATCCCAGCATGAACCTTCAGGGGCTGGCTGTGGGCAATGGACTCTCCTCCTATGAGCAGAATGACAACTCCCTG
GTCTACTTTGCCTACTACCATGGCCTTCTGGGGAACAGGCTTTGGTCTTCTCTCCAGACCCACTGCTGCTCTCAAAACAAGTGTAACTTC
TATGACAACAAAGACCTGGAATGCGTGACCAATCTTCAGGAAGTGGCCCGCATCGTGGGCAACTCTGGCCTCAACATCTACAATCTCTAT
GCCCCGTGTGCTGGAGGGGTGCCCAGCCATTTTAGGTATGAGAAGGACACTGTTGTGGTCCAGGATTTGGGCAACATCTTCACTCGCCTG
CCACTCAAGCGGATGTGGCATCAGGCACTGCTGCGCTCAGGGGATAAAGTGCGCATGGACCCCCCCTGCACCAACACAACAGCTGCTTCC
ACCTACCTCAACAACCCGTACGTGCGGAAGGCCCTCAACATCCCGGAGCAGCTGCCACAATGGGACATGTGCAACTTTCTGGTAAACTTA
CAGTACCGCCGTCTCTACCGAAGCATGAACTCCCAGTATCTGAAGCTGCTTAGCTCACAGAAATACCAGATCCTATTATATAATGGAGAT
GTAGACATGGCCTGCAATTTCATGGGGGATGAGTGGTTTGTGGATTCCCTCAACCAGAAGCGGCCCTGGTTAGTGAAGTACGGGGACAGC
GGGGAGCAGATTGCCGGCTTCGTGAAGGAGTTCTCCCACATCGCCTTTCTCACGATCAAGGGTTGAGTTCCAGAACAAGTTCTATGTCGG
GGATGGTTACAAGTTTTCTCCATTCTCCTTTAAACACATCCTGGATGGCACAGCCGAGGAGTAGGCTGAGGGCTGCACCTCCCACGGTGG
TCACCATGCCAATGAAGGAAGTTCAGTCTTGTCTTTGATATCAGCCCCTGCAAGGCGCTCAATGGGAAGGTTAACTGTCTGAAGTGCTCT
GGACTATGGTGATGAACAGCGGCCTTCAGACGCGAGGCTGGGGAGGAATCGTCGGGGTTTTTATTATTTTTGCCGTATTTGCTGTCCTGA
CAGTAGCCATCCTTCTGATCATGGAGGGCCTCTCTGCTTTCCTGCACGCCCTGCGACTGCACTGTTCAACTTTGGAGACGTCTTTGTCCA
CCAAGCCATCCACACCATCGAGTACTGCCTGGGCTGCATTTCAAACACAGCCTCCTACCTGCGGCTCTGGGCCCTCAGCCTGGCTCATGC

>20447_20447_11_CTSA-ATP6V0A4_CTSA_chr20_44526658_ENST00000372484_ATP6V0A4_chr7_138406708_ENST00000353492_length(amino acids)=467AA_BP=
MTSSPRAPPGEQGRGGAEMIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKD
PENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFR
LFPEYKNNKLFLTGESYAGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNK
DLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLN
NPYVRKALNIPEQLPQWDMCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKRPWLVKYGDSGEQI

--------------------------------------------------------------
>20447_20447_12_CTSA-ATP6V0A4_CTSA_chr20_44526658_ENST00000372484_ATP6V0A4_chr7_138406708_ENST00000393054_length(transcript)=2460nt_BP=1680nt
GCAATGATGGTGACCGCAAGGCGACCTTGTAAGGCATTTCCCCCCTGACTCCCTTCCCCGAGCCTCTGCCCGGGGGTCCTAGCGCCGCTT
TCTCAGCCATCCCGCCTACAACTTAGCCGTCCACAACAGGATCATCTGATCGCGTGCGCCCGGGCTACGATCTGCGAGGCCCGCGGACCT
TGACCCGGCATTGACCGCCACCGCCCCCCAGGTCCGTAGGGACCAAAGAAGGGGCGGGAGGAAGACTGTCACGTGGCGCCGGAGTTCACG
TGACTCGTACACATGACTTCCAGTCCCCGGGCGCCTCCTGGAGAGCAAGGACGCGGGGGAGCAGAGATGATCCGAGCCGCGCCGCCGCCG
CTGTTCCTGCTGCTGCTGCTGCTGCTGCTGCTAGTGTCCTGGGCGTCCCGAGGCGAGGCAGCCCCCGACCAGGACGAGATCCAGCGCCTC
CCCGGGCTGGCCAAGCAGCCGTCTTTCCGCCAGTACTCCGGCTACCTCAAAGGCTCCGGCTCCAAGCACCTCCACTACTGGTTTGTGGAG
TCCCAGAAGGATCCCGAGAACAGCCCTGTGGTGCTTTGGCTCAATGGGGGTCCCGGCTGCAGCTCACTAGATGGGCTCCTCACAGAGCAT
GGCCCCTTCCTGGTCCAGCCAGATGGTGTCACCCTGGAGTACAACCCCTATTCTTGGAATCTGATTGCCAATGTGTTATACCTGGAGTCC
CCAGCTGGGGTGGGCTTCTCCTACTCCGATGACAAGTTTTATGCAACTAATGACACTGAGGTCGCCCAGAGCAATTTTGAGGCCCTTCAA
GATTTCTTCCGCCTCTTTCCGGAGTACAAGAACAACAAACTTTTCCTGACCGGGGAGAGCTATGCTGGCATCTACATCCCCACCCTGGCC
GTGCTGGTCATGCAGGATCCCAGCATGAACCTTCAGGGGCTGGCTGTGGGCAATGGACTCTCCTCCTATGAGCAGAATGACAACTCCCTG
GTCTACTTTGCCTACTACCATGGCCTTCTGGGGAACAGGCTTTGGTCTTCTCTCCAGACCCACTGCTGCTCTCAAAACAAGTGTAACTTC
TATGACAACAAAGACCTGGAATGCGTGACCAATCTTCAGGAAGTGGCCCGCATCGTGGGCAACTCTGGCCTCAACATCTACAATCTCTAT
GCCCCGTGTGCTGGAGGGGTGCCCAGCCATTTTAGGTATGAGAAGGACACTGTTGTGGTCCAGGATTTGGGCAACATCTTCACTCGCCTG
CCACTCAAGCGGATGTGGCATCAGGCACTGCTGCGCTCAGGGGATAAAGTGCGCATGGACCCCCCCTGCACCAACACAACAGCTGCTTCC
ACCTACCTCAACAACCCGTACGTGCGGAAGGCCCTCAACATCCCGGAGCAGCTGCCACAATGGGACATGTGCAACTTTCTGGTAAACTTA
CAGTACCGCCGTCTCTACCGAAGCATGAACTCCCAGTATCTGAAGCTGCTTAGCTCACAGAAATACCAGATCCTATTATATAATGGAGAT
GTAGACATGGCCTGCAATTTCATGGGGGATGAGTGGTTTGTGGATTCCCTCAACCAGAAGCGGCCCTGGTTAGTGAAGTACGGGGACAGC
GGGGAGCAGATTGCCGGCTTCGTGAAGGAGTTCTCCCACATCGCCTTTCTCACGATCAAGGGTTGAGTTCCAGAACAAGTTCTATGTCGG
GGATGGTTACAAGTTTTCTCCATTCTCCTTTAAACACATCCTGGATGGCACAGCCGAGGAGTAGGCTGAGGGCTGCACCTCCCACGGTGG
TCACCATGCCAATGAAGGAAGTTCAGTCTTGTCTTTGATATCAGCCCCTGCAAGGCGCTCAATGGGAAGGTTGTTCTTGGCTCACCTGAA
GCATGAAACTGTGTATTATTTGGACGTCAGCCTGTGGATTTGATACGACTTAACCACGTCAGAGGAAGGACTTTGGCAAGTGATATTGTC
TTCATGTGGGGTATTAATTCTCAAATAATAAAGTAATTGACAAATGAGGGGAGAATGCTAAACAGATGTCTTCTTGCAATATTTTAAATA
TTGTATTTGAGAAAATAAACATCTGAGTCATTCAACTGTCTGAAGTGCTCTGGACTATGGTGATGAACAGCGGCCTTCAGACGCGAGGCT
GGGGAGGAATCGTCGGGGTTTTTATTATTTTTGCCGTATTTGCTGTCCTGACAGTAGCCATCCTTCTGATCATGGAGGGCCTCTCTGCTT
TCCTGCACGCCCTGCGACTGCACTGTTCAACTTTGGAGACGTCTTTGTCCACCAAGCCATCCACACCATCGAGTACTGCCTGGGCTGCAT
TTCAAACACAGCCTCCTACCTGCGGCTCTGGGCCCTCAGCCTGGCTCATGCACTTCTAGCCGTTCTGGCCAGAGGACTTCTGCAGATACC

>20447_20447_12_CTSA-ATP6V0A4_CTSA_chr20_44526658_ENST00000372484_ATP6V0A4_chr7_138406708_ENST00000393054_length(amino acids)=467AA_BP=
MTSSPRAPPGEQGRGGAEMIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKD
PENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFR
LFPEYKNNKLFLTGESYAGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNK
DLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLN
NPYVRKALNIPEQLPQWDMCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKRPWLVKYGDSGEQI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CTSA-ATP6V0A4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CTSA-ATP6V0A4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CTSA-ATP6V0A4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CTSA	C0268233	GALACTOSIALIDOSIS	7	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C1864498	RENAL TUBULAR ACIDOSIS, DISTAL, AUTOSOMAL RECESSIVE	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT

Fusion Gene Studies in Kim Lab

Fusion gene:CTSA-ATP6V0A4 (FusionGDB2 ID:HG5476TG50617)

Fusion Gene Summary for CTSA-ATP6V0A4

Fusion Gene ORF analysis for CTSA-ATP6V0A4

Fusion Genomic Features for CTSA-ATP6V0A4

Fusion Protein Features for CTSA-ATP6V0A4

Fusion Gene Sequence for CTSA-ATP6V0A4

Fusion Gene PPI Analysis for CTSA-ATP6V0A4

Related Drugs for CTSA-ATP6V0A4

Related Diseases for CTSA-ATP6V0A4

Fusion Gene Studies
in Kim Lab