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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:PPM1B-CTNND1 (FusionGDB2 ID:HG5495TG1500)

Fusion Gene Summary for PPM1B-CTNND1

check button Fusion gene summary
Fusion gene informationFusion gene name: PPM1B-CTNND1
Fusion gene ID: hg5495tg1500
HgeneTgene
Gene symbol

PPM1B

CTNND1

Gene ID

5495

1500

Gene nameprotein phosphatase, Mg2+/Mn2+ dependent 1Bcatenin delta 1
SynonymsPP2C-beta|PP2C-beta-X|PP2CB|PP2CBETA|PPC2BETAXBCDS2|CAS|CTNND|P120CAS|P120CTN|p120|p120(CAS)|p120(CTN)
Cytomap('PPM1B')('CTNND1')

2p21

11q12.1

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase 1BSer/Thr protein phosphatase type 2C beta 2 isoformprotein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoformprotein phosphatase 2C-like proteincatenin delta-1cadherin-associated Src substratecatenin (cadherin-associated protein), delta 1p120 catenin
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000378540, ENST00000282412, 
ENST00000345249, ENST00000378551, 
ENST00000409432, ENST00000409895, 
Fusion gene scores* DoF score11 X 7 X 7=53917 X 21 X 10=3570
# samples 1325
** MAII scorelog2(13/539*10)=-2.05177364972405
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/3570*10)=-3.83592407425437
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPM1B [Title/Abstract] AND CTNND1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPM1B(44445676)-CTNND1(57569204), # samples:1
Anticipated loss of major functional domain due to fusion event.PPM1B-CTNND1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PPM1B-CTNND1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
PPM1B-CTNND1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPM1B

GO:0035970

peptidyl-threonine dephosphorylation

20801214

TgeneCTNND1

GO:0099072

regulation of postsynaptic membrane neurotransmitter receptor levels

18602475



check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-59-2363PPM1Bchr2

44445676

+CTNND1chr11

57569204

+


Top

Fusion Gene ORF analysis for PPM1B-CTNND1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000378540ENST00000360682PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-3CDSENST00000378540ENST00000361332PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-3CDSENST00000378540ENST00000361391PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-3CDSENST00000378540ENST00000361796PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-3CDSENST00000378540ENST00000399039PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-3CDSENST00000378540ENST00000428599PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-3CDSENST00000378540ENST00000524630PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-3CDSENST00000378540ENST00000529919PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-3CDSENST00000378540ENST00000530094PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-5UTRENST00000378540ENST00000358694PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-5UTRENST00000378540ENST00000399050PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-5UTRENST00000378540ENST00000415361PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-5UTRENST00000378540ENST00000426142PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-5UTRENST00000378540ENST00000525902PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-5UTRENST00000378540ENST00000526357PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-5UTRENST00000378540ENST00000526772PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-5UTRENST00000378540ENST00000526938PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-5UTRENST00000378540ENST00000527467PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-5UTRENST00000378540ENST00000528232PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-5UTRENST00000378540ENST00000528621PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-5UTRENST00000378540ENST00000529526PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-5UTRENST00000378540ENST00000529873PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-5UTRENST00000378540ENST00000529986PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-5UTRENST00000378540ENST00000530748PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-5UTRENST00000378540ENST00000531014PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-5UTRENST00000378540ENST00000532245PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-5UTRENST00000378540ENST00000532463PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-5UTRENST00000378540ENST00000532649PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-5UTRENST00000378540ENST00000532787PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-5UTRENST00000378540ENST00000532844PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-5UTRENST00000378540ENST00000533667PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
3UTR-5UTRENST00000378540ENST00000534579PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000282412ENST00000358694PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000282412ENST00000399050PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000282412ENST00000415361PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000282412ENST00000426142PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000282412ENST00000525902PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000282412ENST00000526357PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000282412ENST00000526772PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000282412ENST00000526938PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000282412ENST00000527467PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000282412ENST00000528232PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000282412ENST00000528621PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000282412ENST00000529526PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000282412ENST00000529873PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000282412ENST00000529986PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000282412ENST00000530748PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000282412ENST00000531014PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000282412ENST00000532245PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000282412ENST00000532463PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000282412ENST00000532649PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000282412ENST00000532787PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000282412ENST00000532844PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000282412ENST00000533667PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000282412ENST00000534579PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000345249ENST00000358694PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000345249ENST00000399050PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000345249ENST00000415361PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000345249ENST00000426142PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000345249ENST00000525902PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000345249ENST00000526357PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000345249ENST00000526772PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000345249ENST00000526938PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000345249ENST00000527467PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000345249ENST00000528232PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000345249ENST00000528621PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000345249ENST00000529526PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000345249ENST00000529873PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000345249ENST00000529986PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000345249ENST00000530748PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000345249ENST00000531014PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000345249ENST00000532245PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000345249ENST00000532463PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000345249ENST00000532649PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000345249ENST00000532787PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000345249ENST00000532844PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000345249ENST00000533667PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000345249ENST00000534579PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000378551ENST00000358694PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000378551ENST00000399050PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000378551ENST00000415361PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000378551ENST00000426142PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000378551ENST00000525902PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000378551ENST00000526357PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000378551ENST00000526772PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000378551ENST00000526938PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000378551ENST00000527467PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000378551ENST00000528232PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000378551ENST00000528621PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000378551ENST00000529526PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000378551ENST00000529873PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000378551ENST00000529986PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000378551ENST00000530748PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000378551ENST00000531014PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000378551ENST00000532245PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000378551ENST00000532463PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000378551ENST00000532649PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000378551ENST00000532787PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000378551ENST00000532844PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000378551ENST00000533667PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000378551ENST00000534579PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000409432ENST00000358694PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000409432ENST00000399050PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000409432ENST00000415361PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000409432ENST00000426142PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000409432ENST00000525902PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000409432ENST00000526357PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000409432ENST00000526772PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000409432ENST00000526938PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000409432ENST00000527467PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000409432ENST00000528232PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000409432ENST00000528621PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000409432ENST00000529526PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000409432ENST00000529873PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000409432ENST00000529986PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000409432ENST00000530748PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000409432ENST00000531014PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000409432ENST00000532245PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000409432ENST00000532463PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000409432ENST00000532649PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000409432ENST00000532787PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000409432ENST00000532844PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000409432ENST00000533667PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
5CDS-5UTRENST00000409432ENST00000534579PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000282412ENST00000360682PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000282412ENST00000361332PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000282412ENST00000361391PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000282412ENST00000361796PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000282412ENST00000399039PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000282412ENST00000428599PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000282412ENST00000524630PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000282412ENST00000529919PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000282412ENST00000530094PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000345249ENST00000360682PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000345249ENST00000361332PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000345249ENST00000361391PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000345249ENST00000361796PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000345249ENST00000399039PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000345249ENST00000428599PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000345249ENST00000524630PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000345249ENST00000529919PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000345249ENST00000530094PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000378551ENST00000360682PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000378551ENST00000361332PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000378551ENST00000361391PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000378551ENST00000361796PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000378551ENST00000399039PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000378551ENST00000428599PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000378551ENST00000524630PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000378551ENST00000529919PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000378551ENST00000530094PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000409432ENST00000360682PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000409432ENST00000361332PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000409432ENST00000361391PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000409432ENST00000361796PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000409432ENST00000399039PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000409432ENST00000428599PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000409432ENST00000524630PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000409432ENST00000529919PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
Frame-shiftENST00000409432ENST00000530094PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-3CDSENST00000409895ENST00000360682PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-3CDSENST00000409895ENST00000361332PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-3CDSENST00000409895ENST00000361391PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-3CDSENST00000409895ENST00000361796PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-3CDSENST00000409895ENST00000399039PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-3CDSENST00000409895ENST00000428599PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-3CDSENST00000409895ENST00000524630PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-3CDSENST00000409895ENST00000529919PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-3CDSENST00000409895ENST00000530094PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-5UTRENST00000409895ENST00000358694PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-5UTRENST00000409895ENST00000399050PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-5UTRENST00000409895ENST00000415361PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-5UTRENST00000409895ENST00000426142PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-5UTRENST00000409895ENST00000525902PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-5UTRENST00000409895ENST00000526357PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-5UTRENST00000409895ENST00000526772PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-5UTRENST00000409895ENST00000526938PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-5UTRENST00000409895ENST00000527467PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-5UTRENST00000409895ENST00000528232PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-5UTRENST00000409895ENST00000528621PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-5UTRENST00000409895ENST00000529526PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-5UTRENST00000409895ENST00000529873PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-5UTRENST00000409895ENST00000529986PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-5UTRENST00000409895ENST00000530748PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-5UTRENST00000409895ENST00000531014PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-5UTRENST00000409895ENST00000532245PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-5UTRENST00000409895ENST00000532463PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-5UTRENST00000409895ENST00000532649PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-5UTRENST00000409895ENST00000532787PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-5UTRENST00000409895ENST00000532844PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-5UTRENST00000409895ENST00000533667PPM1Bchr2

44445676

+CTNND1chr11

57569204

+
intron-5UTRENST00000409895ENST00000534579PPM1Bchr2

44445676

+CTNND1chr11

57569204

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for PPM1B-CTNND1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PPM1Bchr244445676+CTNND1chr1157569204+4.20E-060.9999958
PPM1Bchr244445676+CTNND1chr1157569204+4.20E-060.9999958


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PPM1B-CTNND1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:44445676/:57569204)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PPM1B-CTNND1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PPM1B-CTNND1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPM1B-CTNND1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPM1B-CTNND1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPM1BC0151744Myocardial Ischemia1CTD_human
HgenePPM1BC1848030Hypotonia-Cystinuria Syndrome1CTD_human
HgenePPM1BC43045372p21 microdeletion syndrome1ORPHANET
TgeneC0008925Cleft Palate1GENOMICS_ENGLAND
TgeneC1861536Blepharo-cheilo-dontic syndrome1ORPHANET