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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ASXL2-HADHA (FusionGDB2 ID:HG55252TG3030)

Fusion Gene Summary for ASXL2-HADHA

check button Fusion gene summary
Fusion gene informationFusion gene name: ASXL2-HADHA
Fusion gene ID: hg55252tg3030
HgeneTgene
Gene symbol

ASXL2

HADHA

Gene ID

55252

3030

Gene nameASXL transcriptional regulator 2hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
SynonymsASXH2|SHAPNSECHA|GBP|HADH|LCEH|LCHAD|MTPA|TP-ALPHA
Cytomap('ASXL2')('HADHA')

2p23.3

2p23.3

Type of geneprotein-codingprotein-coding
Descriptionputative Polycomb group protein ASXL2additional sex combs like 2, transcriptional regulatoradditional sex combs-like protein 2polycomb group protein ASXH2trifunctional enzyme subunit alpha, mitochondrial3-ketoacyl-Coenzyme A (CoA) thiolase, alpha subunit3-oxoacyl-CoA thiolase78 kDa gastrin-binding proteingastrin-binding proteinhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (
Modification date2020031320200313
UniProtAcc

Q76L83

.
Ensembl transtripts involved in fusion geneENST00000336112, ENST00000435504, 
ENST00000272341, ENST00000497092, 
ENST00000404843, 
Fusion gene scores* DoF score18 X 11 X 10=19807 X 6 X 7=294
# samples 249
** MAII scorelog2(24/1980*10)=-3.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/294*10)=-1.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ASXL2 [Title/Abstract] AND HADHA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointASXL2(26101035)-HADHA(26432758), # samples:2
Anticipated loss of major functional domain due to fusion event.ASXL2-HADHA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ASXL2-HADHA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ASXL2-HADHA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ASXL2-HADHA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ASXL2-HADHA seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ASXL2-HADHA seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ASXL2-HADHA seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ASXL2-HADHA seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneASXL2

GO:0035360

positive regulation of peroxisome proliferator activated receptor signaling pathway

21047783

HgeneASXL2

GO:0045600

positive regulation of fat cell differentiation

21047783

HgeneASXL2

GO:0045944

positive regulation of transcription by RNA polymerase II

21047783

TgeneHADHA

GO:0035965

cardiolipin acyl-chain remodeling

23152787


check buttonFusion gene breakpoints across ASXL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across HADHA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A43M-01AASXL2chr2

26101035

-HADHAchr2

26432758

-
ChimerDB4ESCATCGA-L5-A43MASXL2chr2

26101035

-HADHAchr2

26432758

-
ChimerDB4UCECTCGA-AX-A3FW-01AASXL2chr2

26022254

-HADHAchr2

26432758

-


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Fusion Gene ORF analysis for ASXL2-HADHA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000336112ENST00000457468ASXL2chr2

26022254

-HADHAchr2

26432758

-
5CDS-intronENST00000336112ENST00000461025ASXL2chr2

26022254

-HADHAchr2

26432758

-
5CDS-intronENST00000435504ENST00000457468ASXL2chr2

26101035

-HADHAchr2

26432758

-
5CDS-intronENST00000435504ENST00000457468ASXL2chr2

26022254

-HADHAchr2

26432758

-
5CDS-intronENST00000435504ENST00000461025ASXL2chr2

26101035

-HADHAchr2

26432758

-
5CDS-intronENST00000435504ENST00000461025ASXL2chr2

26022254

-HADHAchr2

26432758

-
5UTR-3CDSENST00000272341ENST00000380649ASXL2chr2

26101035

-HADHAchr2

26432758

-
5UTR-3CDSENST00000272341ENST00000380649ASXL2chr2

26022254

-HADHAchr2

26432758

-
5UTR-3CDSENST00000336112ENST00000380649ASXL2chr2

26101035

-HADHAchr2

26432758

-
5UTR-3CDSENST00000497092ENST00000380649ASXL2chr2

26022254

-HADHAchr2

26432758

-
5UTR-intronENST00000272341ENST00000457468ASXL2chr2

26101035

-HADHAchr2

26432758

-
5UTR-intronENST00000272341ENST00000457468ASXL2chr2

26022254

-HADHAchr2

26432758

-
5UTR-intronENST00000272341ENST00000461025ASXL2chr2

26101035

-HADHAchr2

26432758

-
5UTR-intronENST00000272341ENST00000461025ASXL2chr2

26022254

-HADHAchr2

26432758

-
5UTR-intronENST00000336112ENST00000457468ASXL2chr2

26101035

-HADHAchr2

26432758

-
5UTR-intronENST00000336112ENST00000461025ASXL2chr2

26101035

-HADHAchr2

26432758

-
5UTR-intronENST00000497092ENST00000457468ASXL2chr2

26022254

-HADHAchr2

26432758

-
5UTR-intronENST00000497092ENST00000461025ASXL2chr2

26022254

-HADHAchr2

26432758

-
Frame-shiftENST00000435504ENST00000380649ASXL2chr2

26022254

-HADHAchr2

26432758

-
In-frameENST00000336112ENST00000380649ASXL2chr2

26022254

-HADHAchr2

26432758

-
In-frameENST00000435504ENST00000380649ASXL2chr2

26101035

-HADHAchr2

26432758

-
intron-3CDSENST00000404843ENST00000380649ASXL2chr2

26101035

-HADHAchr2

26432758

-
intron-3CDSENST00000404843ENST00000380649ASXL2chr2

26022254

-HADHAchr2

26432758

-
intron-3CDSENST00000497092ENST00000380649ASXL2chr2

26101035

-HADHAchr2

26432758

-
intron-intronENST00000404843ENST00000457468ASXL2chr2

26101035

-HADHAchr2

26432758

-
intron-intronENST00000404843ENST00000457468ASXL2chr2

26022254

-HADHAchr2

26432758

-
intron-intronENST00000404843ENST00000461025ASXL2chr2

26101035

-HADHAchr2

26432758

-
intron-intronENST00000404843ENST00000461025ASXL2chr2

26022254

-HADHAchr2

26432758

-
intron-intronENST00000497092ENST00000457468ASXL2chr2

26101035

-HADHAchr2

26432758

-
intron-intronENST00000497092ENST00000461025ASXL2chr2

26101035

-HADHAchr2

26432758

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000435504ASXL2chr226101035-ENST00000380649HADHAchr226432758-22833511531667504
ENST00000336112ASXL2chr226022254-ENST00000380649HADHAchr226432758-25796475511963470

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000435504ENST00000380649ASXL2chr226101035-HADHAchr226432758-0.0017205730.99827945
ENST00000336112ENST00000380649ASXL2chr226022254-HADHAchr226432758-0.0018448940.99815506

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Fusion Genomic Features for ASXL2-HADHA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ASXL2-HADHA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:26101035/chr2:26432758)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ASXL2

Q76L83

.
FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. {ECO:0000250, ECO:0000269|PubMed:21047783}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASXL2chr2:26022254chr2:26432758ENST00000435504-51311_861341436.0DomainHTH HARE-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASXL2chr2:26022254chr2:26432758ENST00000272341-4131173_11760919.0Compositional biasNote=Poly-Ser
HgeneASXL2chr2:26022254chr2:26432758ENST00000272341-413303_3070919.0Compositional biasNote=Poly-Leu
HgeneASXL2chr2:26022254chr2:26432758ENST00000272341-413654_6840919.0Compositional biasNote=Ala-rich
HgeneASXL2chr2:26022254chr2:26432758ENST00000272341-413687_7390919.0Compositional biasNote=Gly-rich
HgeneASXL2chr2:26022254chr2:26432758ENST00000272341-41395_2350919.0Compositional biasNote=Ser-rich
HgeneASXL2chr2:26022254chr2:26432758ENST00000404843-1101173_11760919.0Compositional biasNote=Poly-Ser
HgeneASXL2chr2:26022254chr2:26432758ENST00000404843-110303_3070919.0Compositional biasNote=Poly-Leu
HgeneASXL2chr2:26022254chr2:26432758ENST00000404843-110654_6840919.0Compositional biasNote=Ala-rich
HgeneASXL2chr2:26022254chr2:26432758ENST00000404843-110687_7390919.0Compositional biasNote=Gly-rich
HgeneASXL2chr2:26022254chr2:26432758ENST00000404843-11095_2350919.0Compositional biasNote=Ser-rich
HgeneASXL2chr2:26022254chr2:26432758ENST00000435504-5131173_11761341436.0Compositional biasNote=Poly-Ser
HgeneASXL2chr2:26022254chr2:26432758ENST00000435504-513303_3071341436.0Compositional biasNote=Poly-Leu
HgeneASXL2chr2:26022254chr2:26432758ENST00000435504-513654_6841341436.0Compositional biasNote=Ala-rich
HgeneASXL2chr2:26022254chr2:26432758ENST00000435504-513687_7391341436.0Compositional biasNote=Gly-rich
HgeneASXL2chr2:26022254chr2:26432758ENST00000435504-51395_2351341436.0Compositional biasNote=Ser-rich
HgeneASXL2chr2:26101035chr2:26432758ENST00000272341-1131173_11760919.0Compositional biasNote=Poly-Ser
HgeneASXL2chr2:26101035chr2:26432758ENST00000272341-113303_3070919.0Compositional biasNote=Poly-Leu
HgeneASXL2chr2:26101035chr2:26432758ENST00000272341-113654_6840919.0Compositional biasNote=Ala-rich
HgeneASXL2chr2:26101035chr2:26432758ENST00000272341-113687_7390919.0Compositional biasNote=Gly-rich
HgeneASXL2chr2:26101035chr2:26432758ENST00000272341-11395_2350919.0Compositional biasNote=Ser-rich
HgeneASXL2chr2:26101035chr2:26432758ENST00000404843-1101173_11760919.0Compositional biasNote=Poly-Ser
HgeneASXL2chr2:26101035chr2:26432758ENST00000404843-110303_3070919.0Compositional biasNote=Poly-Leu
HgeneASXL2chr2:26101035chr2:26432758ENST00000404843-110654_6840919.0Compositional biasNote=Ala-rich
HgeneASXL2chr2:26101035chr2:26432758ENST00000404843-110687_7390919.0Compositional biasNote=Gly-rich
HgeneASXL2chr2:26101035chr2:26432758ENST00000404843-11095_2350919.0Compositional biasNote=Ser-rich
HgeneASXL2chr2:26101035chr2:26432758ENST00000435504-1131173_1176191436.0Compositional biasNote=Poly-Ser
HgeneASXL2chr2:26101035chr2:26432758ENST00000435504-113303_307191436.0Compositional biasNote=Poly-Leu
HgeneASXL2chr2:26101035chr2:26432758ENST00000435504-113654_684191436.0Compositional biasNote=Ala-rich
HgeneASXL2chr2:26101035chr2:26432758ENST00000435504-113687_739191436.0Compositional biasNote=Gly-rich
HgeneASXL2chr2:26101035chr2:26432758ENST00000435504-11395_235191436.0Compositional biasNote=Ser-rich
HgeneASXL2chr2:26022254chr2:26432758ENST00000272341-41311_860919.0DomainHTH HARE-type
HgeneASXL2chr2:26022254chr2:26432758ENST00000272341-413274_3830919.0DomainDEUBAD
HgeneASXL2chr2:26022254chr2:26432758ENST00000404843-11011_860919.0DomainHTH HARE-type
HgeneASXL2chr2:26022254chr2:26432758ENST00000404843-110274_3830919.0DomainDEUBAD
HgeneASXL2chr2:26022254chr2:26432758ENST00000435504-513274_3831341436.0DomainDEUBAD
HgeneASXL2chr2:26101035chr2:26432758ENST00000272341-11311_860919.0DomainHTH HARE-type
HgeneASXL2chr2:26101035chr2:26432758ENST00000272341-113274_3830919.0DomainDEUBAD
HgeneASXL2chr2:26101035chr2:26432758ENST00000404843-11011_860919.0DomainHTH HARE-type
HgeneASXL2chr2:26101035chr2:26432758ENST00000404843-110274_3830919.0DomainDEUBAD
HgeneASXL2chr2:26101035chr2:26432758ENST00000435504-11311_86191436.0DomainHTH HARE-type
HgeneASXL2chr2:26101035chr2:26432758ENST00000435504-113274_383191436.0DomainDEUBAD
HgeneASXL2chr2:26022254chr2:26432758ENST00000272341-413174_1780919.0MotifNuclear localization signal
HgeneASXL2chr2:26022254chr2:26432758ENST00000272341-413887_8910919.0MotifNote=LXXLL motif 2
HgeneASXL2chr2:26022254chr2:26432758ENST00000404843-110174_1780919.0MotifNuclear localization signal
HgeneASXL2chr2:26022254chr2:26432758ENST00000404843-110887_8910919.0MotifNote=LXXLL motif 2
HgeneASXL2chr2:26022254chr2:26432758ENST00000435504-513174_1781341436.0MotifNuclear localization signal
HgeneASXL2chr2:26022254chr2:26432758ENST00000435504-513887_8911341436.0MotifNote=LXXLL motif 2
HgeneASXL2chr2:26101035chr2:26432758ENST00000272341-113174_1780919.0MotifNuclear localization signal
HgeneASXL2chr2:26101035chr2:26432758ENST00000272341-113887_8910919.0MotifNote=LXXLL motif 2
HgeneASXL2chr2:26101035chr2:26432758ENST00000404843-110174_1780919.0MotifNuclear localization signal
HgeneASXL2chr2:26101035chr2:26432758ENST00000404843-110887_8910919.0MotifNote=LXXLL motif 2
HgeneASXL2chr2:26101035chr2:26432758ENST00000435504-113174_178191436.0MotifNuclear localization signal
HgeneASXL2chr2:26101035chr2:26432758ENST00000435504-113887_891191436.0MotifNote=LXXLL motif 2
HgeneASXL2chr2:26022254chr2:26432758ENST00000272341-4131397_14340919.0Zinc fingerNote=PHD-type%3B atypical
HgeneASXL2chr2:26022254chr2:26432758ENST00000404843-1101397_14340919.0Zinc fingerNote=PHD-type%3B atypical
HgeneASXL2chr2:26022254chr2:26432758ENST00000435504-5131397_14341341436.0Zinc fingerNote=PHD-type%3B atypical
HgeneASXL2chr2:26101035chr2:26432758ENST00000272341-1131397_14340919.0Zinc fingerNote=PHD-type%3B atypical
HgeneASXL2chr2:26101035chr2:26432758ENST00000404843-1101397_14340919.0Zinc fingerNote=PHD-type%3B atypical
HgeneASXL2chr2:26101035chr2:26432758ENST00000435504-1131397_1434191436.0Zinc fingerNote=PHD-type%3B atypical


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Fusion Gene Sequence for ASXL2-HADHA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7307_7307_1_ASXL2-HADHA_ASXL2_chr2_26022254_ENST00000336112_HADHA_chr2_26432758_ENST00000380649_length(transcript)=2579nt_BP=647nt
GTACAGTAAGAACCCAATATGGCAGCGGCGGTAGCAGTGGCAACGGCAGCAAGAGGACCGGCCGCCCCATAGACCCCCCCGCGCACCACC
CCCGCCGCTTCCTCTGCTTGGGTGCCCCCCCGGTCTGACTTCCCTTTTCTCCCACCTTTCCCGGCACCGCGGGAAAAGCAGCGCAGGGCA
GAGCAGGCAGGGAGGGCGGCCGGAGCCCGGACACGGGAGCCTCCCAGTCAGTTCAAGACCCGACATGAGGGAAAAGGGACGTAGGAAGAA
GGGCAGGACCTGGGCGGAGGCCGCCAAGACGGTCTTAGAAAAATACCCCAATACACCCATGAGTCATAAAGAAATTCTTCAAGTTATCCA
GAGAGAAGGACTAAAAGAAATCAGCAGTGGGACTTCTCCTCTTGCATGCCTGAATGCAATGCTTCACACAAACTCCAGAGGTGAAGAGGG
CATCTTCTATAAGGTTCCAGGTAGAATGGGAGTATATACTTTGAAGAAAGATGTGCCGGATGGGGTGAAAGAGCTGTCAGAAGGTTCAGA
AGAAAGCAGTGATGGTCAGTCAGATTCCCAGAGTTCTGAGAACAGCAGCAGCAGCAGTGATGGTGGCAGCAACAAGGAGGGAAAAAAGAG
CAGGTGGAAAAGGAAAGAAATTTGGAGAGCTTGTAATGACCAAAGAATCAAAGGCCTTGATGGGACTCTACCATGGTCAGGTCCTGTGCA
AGAAGAATAAATTTGGAGCTCCACAGAAGGATGTTAAGCATCTGGCTATTCTTGGTGCAGGGCTGATGGGAGCAGGCATCGCCCAAGTCT
CCGTGGATAAGGGGCTAAAGACTATACTTAAAGATGCCACCCTCACTGCGCTAGACCGAGGACAGCAACAAGTGTTCAAAGGATTGAATG
ACAAAGTGAAGAAGAAAGCTCTAACATCATTTGAAAGGGATTCCATCTTCAGCAACTTGACTGGGCAGCTTGATTACCAAGGTTTTGAAA
AGGCCGACATGGTGATTGAAGCTGTGTTTGAGGACCTTAGTCTTAAGCACAGAGTGCTAAAGGAAGTAGAAGCGGTGATTCCAGATCACT
GTATCTTTGCCAGTAACACATCTGCTCTCCCAATCAGTGAAATCGCTGCTGTCAGCAAAAGACCTGAGAAGGTGATTGGCATGCACTACT
TCTCTCCCGTGGACAAGATGCAGCTGCTGGAGATTATCACGACCGAGAAAACTTCCAAAGACACCAGTGCTTCAGCTGTAGCAGTTGGTC
TCAAGCAGGGGAAGGTCATCATTGTGGTTAAGGATGGACCTGGCTTCTATACTACCAGGTGTCTTGCGCCCATGATGTCTGAAGTCATCC
GAATCCTCCAGGAAGGAGTTGACCCGAAGAAGCTGGATTCCCTGACCACAAGCTTTGGCTTTCCTGTGGGTGCCGCCACACTGGTGGATG
AAGTTGGTGTGGATGTAGCGAAACATGTGGCGGAAGATCTGGGCAAAGTCTTTGGGGAGCGGTTTGGAGGTGGAAACCCAGAACTGCTGA
CACAGATGGTGTCCAAGGGCTTCCTAGGTCGTAAATCTGGGAAGGGCTTTTACATCTATCAGGAGGGTGTGAAGAGGAAGGATTTGAATT
CTGACATGGATAGTATTTTAGCGAGTCTGAAGCTGCCTCCTAAGTCTGAAGTCTCATCAGACGAAGACATCCAGTTCCGCCTGGTGACAA
GATTTGTGAATGAGGCAGTCATGTGCCTGCAAGAGGGGATCTTGGCCACACCTGCAGAGGGAGACATCGGAGCCGTCTTTGGGCTTGGCT
TCCCGCCTTGTCTGGGAGGGCCTTTCCGCTTTGTGGATCTGTATGGCGCCCAGAAGATAGTGGACCGGCTCAAGAAATATGAAGCTGCCT
ATGGAAAACAGTTCACCCCATGCCAGCTGCTAGCTGACCATGCTAACAGCCCTAACAAGAAGTTCTACCAGTGAGCAGGCCTCATGCCTC
GCTCAGTCAGTGCACTAACCCCAGCTGCCGGCAGTGCTGGTTCTCCAACAGAGTGGTGTCTAGATTTATCAGAGTAACGAGAAGACAAAC
TCCGGCACTGGGTTTGCTCCCTGATTAAAGTGCCTTCAGCCAAGACCATCTCTCCCTCCTGGTGAAGTGTGACTTCGAATTAGTTTGCAC
TTCCTGTTGGAAGGTAGAGCCCACTGCTCATTGTATAAGCCCCGAGGCCTAGAGTGGCAGCCAAGAGCCATCTGAAGCCACCTCTCTGCC
TGTTCCTCCCAAGAGGCCAGGGTGGCCAGGGGTGGTGAGGGCAGTTCTGCACCCAGCCAAACACATAACAATAAAAACCAAACTCTGTGT
CAGCATCTTTGCCCTTCTGGTTTAAACGCCTCCTTCAAAAAGCAATCTGGAAGAAAGCCCTGTGCTTTGGGGGAGTAAGAATGTGTGTGC
AGAATTCTAGGCAGCACCTTAGGGAGGGACTGGGATGAGAGAAAGTGGGACCTGGTGGGCTCAACCACACACACCTGTCTGTGCAGATGC

>7307_7307_1_ASXL2-HADHA_ASXL2_chr2_26022254_ENST00000336112_HADHA_chr2_26432758_ENST00000380649_length(amino acids)=470AA_BP=32
MVSQIPRVLRTAAAAVMVAATRREKRAGGKGKKFGELVMTKESKALMGLYHGQVLCKKNKFGAPQKDVKHLAILGAGLMGAGIAQVSVDK
GLKTILKDATLTALDRGQQQVFKGLNDKVKKKALTSFERDSIFSNLTGQLDYQGFEKADMVIEAVFEDLSLKHRVLKEVEAVIPDHCIFA
SNTSALPISEIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEKTSKDTSASAVAVGLKQGKVIIVVKDGPGFYTTRCLAPMMSEVIRILQ
EGVDPKKLDSLTTSFGFPVGAATLVDEVGVDVAKHVAEDLGKVFGERFGGGNPELLTQMVSKGFLGRKSGKGFYIYQEGVKRKDLNSDMD
SILASLKLPPKSEVSSDEDIQFRLVTRFVNEAVMCLQEGILATPAEGDIGAVFGLGFPPCLGGPFRFVDLYGAQKIVDRLKKYEAAYGKQ

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>7307_7307_2_ASXL2-HADHA_ASXL2_chr2_26101035_ENST00000435504_HADHA_chr2_26432758_ENST00000380649_length(transcript)=2283nt_BP=351nt
ACAGTAGTGACGGCCGCGCGGGAGCGGTCACATGACCGTAGCGGCAGCCTGTACAGTAAGAACCCAATATGGCAGCGGCGGTAGCAGTGG
CAACGGCAGCAAGAGGACCGGCCGCCCCATAGACCCCCCCGCGCACCACCCCCGCCGCTTCCTCTGCTTGGGTGCCCCCCCGGTCTGACT
TCCCTTTTCTCCCACCTTTCCCGGCACCGCGGGAAAAGCAGCGCAGGGCAGAGCAGGCAGGGAGGGCGGCCGGAGCCCGGACACGGGAGC
CTCCCAGTCAGTTCAAGACCCGACATGAGGGAAAAGGGACGTAGGAAGAAGGGCAGGACCTGGGCGGAGGCCGCCAAGACGAAATTTGGA
GAGCTTGTAATGACCAAAGAATCAAAGGCCTTGATGGGACTCTACCATGGTCAGGTCCTGTGCAAGAAGAATAAATTTGGAGCTCCACAG
AAGGATGTTAAGCATCTGGCTATTCTTGGTGCAGGGCTGATGGGAGCAGGCATCGCCCAAGTCTCCGTGGATAAGGGGCTAAAGACTATA
CTTAAAGATGCCACCCTCACTGCGCTAGACCGAGGACAGCAACAAGTGTTCAAAGGATTGAATGACAAAGTGAAGAAGAAAGCTCTAACA
TCATTTGAAAGGGATTCCATCTTCAGCAACTTGACTGGGCAGCTTGATTACCAAGGTTTTGAAAAGGCCGACATGGTGATTGAAGCTGTG
TTTGAGGACCTTAGTCTTAAGCACAGAGTGCTAAAGGAAGTAGAAGCGGTGATTCCAGATCACTGTATCTTTGCCAGTAACACATCTGCT
CTCCCAATCAGTGAAATCGCTGCTGTCAGCAAAAGACCTGAGAAGGTGATTGGCATGCACTACTTCTCTCCCGTGGACAAGATGCAGCTG
CTGGAGATTATCACGACCGAGAAAACTTCCAAAGACACCAGTGCTTCAGCTGTAGCAGTTGGTCTCAAGCAGGGGAAGGTCATCATTGTG
GTTAAGGATGGACCTGGCTTCTATACTACCAGGTGTCTTGCGCCCATGATGTCTGAAGTCATCCGAATCCTCCAGGAAGGAGTTGACCCG
AAGAAGCTGGATTCCCTGACCACAAGCTTTGGCTTTCCTGTGGGTGCCGCCACACTGGTGGATGAAGTTGGTGTGGATGTAGCGAAACAT
GTGGCGGAAGATCTGGGCAAAGTCTTTGGGGAGCGGTTTGGAGGTGGAAACCCAGAACTGCTGACACAGATGGTGTCCAAGGGCTTCCTA
GGTCGTAAATCTGGGAAGGGCTTTTACATCTATCAGGAGGGTGTGAAGAGGAAGGATTTGAATTCTGACATGGATAGTATTTTAGCGAGT
CTGAAGCTGCCTCCTAAGTCTGAAGTCTCATCAGACGAAGACATCCAGTTCCGCCTGGTGACAAGATTTGTGAATGAGGCAGTCATGTGC
CTGCAAGAGGGGATCTTGGCCACACCTGCAGAGGGAGACATCGGAGCCGTCTTTGGGCTTGGCTTCCCGCCTTGTCTGGGAGGGCCTTTC
CGCTTTGTGGATCTGTATGGCGCCCAGAAGATAGTGGACCGGCTCAAGAAATATGAAGCTGCCTATGGAAAACAGTTCACCCCATGCCAG
CTGCTAGCTGACCATGCTAACAGCCCTAACAAGAAGTTCTACCAGTGAGCAGGCCTCATGCCTCGCTCAGTCAGTGCACTAACCCCAGCT
GCCGGCAGTGCTGGTTCTCCAACAGAGTGGTGTCTAGATTTATCAGAGTAACGAGAAGACAAACTCCGGCACTGGGTTTGCTCCCTGATT
AAAGTGCCTTCAGCCAAGACCATCTCTCCCTCCTGGTGAAGTGTGACTTCGAATTAGTTTGCACTTCCTGTTGGAAGGTAGAGCCCACTG
CTCATTGTATAAGCCCCGAGGCCTAGAGTGGCAGCCAAGAGCCATCTGAAGCCACCTCTCTGCCTGTTCCTCCCAAGAGGCCAGGGTGGC
CAGGGGTGGTGAGGGCAGTTCTGCACCCAGCCAAACACATAACAATAAAAACCAAACTCTGTGTCAGCATCTTTGCCCTTCTGGTTTAAA
CGCCTCCTTCAAAAAGCAATCTGGAAGAAAGCCCTGTGCTTTGGGGGAGTAAGAATGTGTGTGCAGAATTCTAGGCAGCACCTTAGGGAG
GGACTGGGATGAGAGAAAGTGGGACCTGGTGGGCTCAACCACACACACCTGTCTGTGCAGATGCTTTGCCCAGGCTTCTCACCACGGTGT

>7307_7307_2_ASXL2-HADHA_ASXL2_chr2_26101035_ENST00000435504_HADHA_chr2_26432758_ENST00000380649_length(amino acids)=504AA_BP=66
MLGCPPGLTSLFSHLSRHRGKSSAGQSRQGGRPEPGHGSLPVSSRPDMREKGRRKKGRTWAEAAKTKFGELVMTKESKALMGLYHGQVLC
KKNKFGAPQKDVKHLAILGAGLMGAGIAQVSVDKGLKTILKDATLTALDRGQQQVFKGLNDKVKKKALTSFERDSIFSNLTGQLDYQGFE
KADMVIEAVFEDLSLKHRVLKEVEAVIPDHCIFASNTSALPISEIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEKTSKDTSASAVAVG
LKQGKVIIVVKDGPGFYTTRCLAPMMSEVIRILQEGVDPKKLDSLTTSFGFPVGAATLVDEVGVDVAKHVAEDLGKVFGERFGGGNPELL
TQMVSKGFLGRKSGKGFYIYQEGVKRKDLNSDMDSILASLKLPPKSEVSSDEDIQFRLVTRFVNEAVMCLQEGILATPAEGDIGAVFGLG

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Fusion Gene PPI Analysis for ASXL2-HADHA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ASXL2-HADHA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ASXL2-HADHA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneASXL2C0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneASXL2C0005695Bladder Neoplasm1CTD_human
HgeneASXL2C0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneASXL2C0026998Acute Myeloid Leukemia, M11CTD_human
HgeneASXL2C1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
HgeneASXL2C4310672SHASHI-PENA SYNDROME1GENOMICS_ENGLAND
TgeneC3711645Long chain 3-hydroxyacyl-CoA dehydrogenase deficiency9CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC1969443Trifunctional Protein Deficiency With Myopathy And Neuropathy3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0019193Hepatitis, Toxic1CTD_human
TgeneC0029408Degenerative polyarthritis1CTD_human
TgeneC0086743Osteoarthrosis Deformans1CTD_human
TgeneC0151744Myocardial Ischemia1CTD_human
TgeneC0369183Erythrocyte Mean Corpuscular Hemoglobin Test1GENOMICS_ENGLAND
TgeneC0860207Drug-Induced Liver Disease1CTD_human
TgeneC1261502Finding of Mean Corpuscular Hemoglobin1GENOMICS_ENGLAND
TgeneC1262760Hepatitis, Drug-Induced1CTD_human
TgeneC1455728Acute fatty liver of pregnancy1ORPHANET
TgeneC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneC4279912Chemically-Induced Liver Toxicity1CTD_human