Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ARFGAP1-ARFGAP1 (FusionGDB2 ID:HG55738TG55738)

Fusion Gene Summary for ARFGAP1-ARFGAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARFGAP1-ARFGAP1
Fusion gene ID: hg55738tg55738
HgeneTgene
Gene symbol

ARFGAP1

ARFGAP1

Gene ID

55738

55738

Gene nameADP ribosylation factor GTPase activating protein 1ADP ribosylation factor GTPase activating protein 1
SynonymsARF1GAP|HRIHFB2281ARF1GAP|HRIHFB2281
Cytomap('ARFGAP1')('ARFGAP1')

20q13.33

20q13.33

Type of geneprotein-codingprotein-coding
DescriptionADP-ribosylation factor GTPase-activating protein 1ARF1-directed GTPase-activating proteinADP-ribosylation factor GTPase-activating protein 1ARF1-directed GTPase-activating protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000353546, ENST00000370275, 
ENST00000370283, ENST00000518794, 
ENST00000519273, ENST00000519604, 
ENST00000547204, 		ENST00000370275, 
ENST00000370283, ENST00000353546, 
ENST00000518794, ENST00000519273, 
ENST00000519604, ENST00000547204, 
Fusion gene scores* DoF score4 X 5 X 4=807 X 8 X 4=224
# samples 78
** MAII scorelog2(7/80*10)=-0.192645077942396
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARFGAP1 [Title/Abstract] AND ARFGAP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARFGAP1(61919533)-ARFGAP1(61921078), # samples:2
ARFGAP1(61921078)-ARFGAP1(61919533), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA402828ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
ChiTaRS5.0N/AAA454556ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
ChiTaRS5.0N/AAA456448ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
ChiTaRS5.0N/ABF435836ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+


Top

Fusion Gene ORF analysis for ARFGAP1-ARFGAP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000353546ENST00000370275ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-3UTRENST00000353546ENST00000370283ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-3UTRENST00000370275ENST00000353546ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-3UTRENST00000370275ENST00000370275ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-3UTRENST00000370275ENST00000370275ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-3UTRENST00000370275ENST00000370283ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-3UTRENST00000370275ENST00000370283ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-3UTRENST00000370275ENST00000518794ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-3UTRENST00000370275ENST00000519273ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-3UTRENST00000370283ENST00000353546ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-3UTRENST00000370283ENST00000370275ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-3UTRENST00000370283ENST00000370275ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-3UTRENST00000370283ENST00000370283ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-3UTRENST00000370283ENST00000370283ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-3UTRENST00000370283ENST00000518794ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-3UTRENST00000370283ENST00000519273ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-3UTRENST00000518794ENST00000370275ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-3UTRENST00000518794ENST00000370283ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-3UTRENST00000519273ENST00000370275ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-3UTRENST00000519273ENST00000370283ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000353546ENST00000353546ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000353546ENST00000518794ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000353546ENST00000519273ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000353546ENST00000519604ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000353546ENST00000547204ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000370275ENST00000353546ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000370275ENST00000518794ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000370275ENST00000519273ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000370275ENST00000519604ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000370275ENST00000519604ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-intronENST00000370275ENST00000547204ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000370275ENST00000547204ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-intronENST00000370283ENST00000353546ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000370283ENST00000518794ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000370283ENST00000519273ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000370283ENST00000519604ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000370283ENST00000519604ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-intronENST00000370283ENST00000547204ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000370283ENST00000547204ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
3UTR-intronENST00000518794ENST00000353546ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000518794ENST00000518794ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000518794ENST00000519273ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000518794ENST00000519604ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000518794ENST00000547204ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000519273ENST00000353546ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000519273ENST00000518794ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000519273ENST00000519273ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000519273ENST00000519604ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
3UTR-intronENST00000519273ENST00000547204ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-3UTRENST00000353546ENST00000353546ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000353546ENST00000370275ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000353546ENST00000370283ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000353546ENST00000518794ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000353546ENST00000519273ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000518794ENST00000353546ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000518794ENST00000370275ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000518794ENST00000370283ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000518794ENST00000518794ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000518794ENST00000519273ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000519273ENST00000353546ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000519273ENST00000370275ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000519273ENST00000370283ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000519273ENST00000518794ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000519273ENST00000519273ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000519604ENST00000353546ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000519604ENST00000370275ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-3UTRENST00000519604ENST00000370275ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000519604ENST00000370283ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-3UTRENST00000519604ENST00000370283ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000519604ENST00000518794ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000519604ENST00000519273ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000547204ENST00000353546ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000547204ENST00000370275ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-3UTRENST00000547204ENST00000370275ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000547204ENST00000370283ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-3UTRENST00000547204ENST00000370283ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000547204ENST00000518794ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-3UTRENST00000547204ENST00000519273ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-intronENST00000353546ENST00000519604ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-intronENST00000353546ENST00000547204ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-intronENST00000518794ENST00000519604ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-intronENST00000518794ENST00000547204ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-intronENST00000519273ENST00000519604ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-intronENST00000519273ENST00000547204ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-intronENST00000519604ENST00000353546ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-intronENST00000519604ENST00000518794ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-intronENST00000519604ENST00000519273ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-intronENST00000519604ENST00000519604ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-intronENST00000519604ENST00000519604ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-intronENST00000519604ENST00000547204ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-intronENST00000519604ENST00000547204ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-intronENST00000547204ENST00000353546ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-intronENST00000547204ENST00000518794ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-intronENST00000547204ENST00000519273ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-intronENST00000547204ENST00000519604ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-intronENST00000547204ENST00000519604ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+
intron-intronENST00000547204ENST00000547204ARFGAP1chr20

61919533

-ARFGAP1chr20

61921078

-
intron-intronENST00000547204ENST00000547204ARFGAP1chr20

61921078

+ARFGAP1chr20

61919533

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for ARFGAP1-ARFGAP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


Top

Fusion Protein Features for ARFGAP1-ARFGAP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:61919533/:61921078)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for ARFGAP1-ARFGAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for ARFGAP1-ARFGAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ARFGAP1-ARFGAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ARFGAP1-ARFGAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARFGAP1C0008073Developmental Disabilities1CTD_human
HgeneARFGAP1C0027765nervous system disorder1CTD_human
HgeneARFGAP1C0085996Child Development Deviations1CTD_human
HgeneARFGAP1C0085997Child Development Disorders, Specific1CTD_human
TgeneC0008073Developmental Disabilities1CTD_human
TgeneC0027765nervous system disorder1CTD_human
TgeneC0085996Child Development Deviations1CTD_human
TgeneC0085997Child Development Disorders, Specific1CTD_human