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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KDM3A-IVNS1ABP (FusionGDB2 ID:HG55818TG10625)

Fusion Gene Summary for KDM3A-IVNS1ABP

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM3A-IVNS1ABP
Fusion gene ID: hg55818tg10625
HgeneTgene
Gene symbol

KDM3A

IVNS1ABP

Gene ID

55818

10625

Gene namelysine demethylase 3Ainfluenza virus NS1A binding protein
SynonymsJHDM2A|JHMD2A|JMJD1|JMJD1A|TSGAARA3|FLARA3|HSPC068|KLHL39|ND1|NS-1|NS1-BP|NS1BP
Cytomap('KDM3A')('IVNS1ABP')

2p11.2

1q25.3

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 3AjmjC domain-containing histone demethylation protein 2Ajumonji C domain-containing histone demethylase 2Ajumonji domain-containing protein 1Alysine (K)-specific demethylase 3Atestis-specific protein Ainfluenza virus NS1A-binding proteinNCX downstream gene 1NS1-binding proteinaryl hydrocarbon receptor-associated 3aryl hydrocarbon receptor-associated protein 3kelch-like family member 39kelch-like protein 39
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000312912, ENST00000409064, 
ENST00000409556, ENST00000542128, 
ENST00000485171, 
Fusion gene scores* DoF score13 X 12 X 7=109217 X 9 X 9=1377
# samples 1518
** MAII scorelog2(15/1092*10)=-2.86393845042397
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1377*10)=-2.93545974780529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KDM3A [Title/Abstract] AND IVNS1ABP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKDM3A(86709225)-IVNS1ABP(185276794), # samples:1
Anticipated loss of major functional domain due to fusion event.KDM3A-IVNS1ABP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM3A-IVNS1ABP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM3A-IVNS1ABP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM3A-IVNS1ABP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM3A

GO:0009755

hormone-mediated signaling pathway

16603237

HgeneKDM3A

GO:0030521

androgen receptor signaling pathway

16603237

HgeneKDM3A

GO:0033169

histone H3-K9 demethylation

16603237

HgeneKDM3A

GO:0046293

formaldehyde biosynthetic process

16603237


check buttonFusion gene breakpoints across KDM3A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across IVNS1ABP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0878-01AKDM3Achr2

86709225

+IVNS1ABPchr1

185276794

-


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Fusion Gene ORF analysis for KDM3A-IVNS1ABP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000312912ENST00000392007KDM3Achr2

86709225

+IVNS1ABPchr1

185276794

-
5CDS-5UTRENST00000312912ENST00000459929KDM3Achr2

86709225

+IVNS1ABPchr1

185276794

-
5CDS-5UTRENST00000409064ENST00000392007KDM3Achr2

86709225

+IVNS1ABPchr1

185276794

-
5CDS-5UTRENST00000409064ENST00000459929KDM3Achr2

86709225

+IVNS1ABPchr1

185276794

-
5CDS-5UTRENST00000409556ENST00000392007KDM3Achr2

86709225

+IVNS1ABPchr1

185276794

-
5CDS-5UTRENST00000409556ENST00000459929KDM3Achr2

86709225

+IVNS1ABPchr1

185276794

-
5CDS-5UTRENST00000542128ENST00000392007KDM3Achr2

86709225

+IVNS1ABPchr1

185276794

-
5CDS-5UTRENST00000542128ENST00000459929KDM3Achr2

86709225

+IVNS1ABPchr1

185276794

-
5CDS-intronENST00000312912ENST00000367497KDM3Achr2

86709225

+IVNS1ABPchr1

185276794

-
5CDS-intronENST00000409064ENST00000367497KDM3Achr2

86709225

+IVNS1ABPchr1

185276794

-
5CDS-intronENST00000409556ENST00000367497KDM3Achr2

86709225

+IVNS1ABPchr1

185276794

-
5CDS-intronENST00000542128ENST00000367497KDM3Achr2

86709225

+IVNS1ABPchr1

185276794

-
In-frameENST00000312912ENST00000367498KDM3Achr2

86709225

+IVNS1ABPchr1

185276794

-
In-frameENST00000409064ENST00000367498KDM3Achr2

86709225

+IVNS1ABPchr1

185276794

-
In-frameENST00000409556ENST00000367498KDM3Achr2

86709225

+IVNS1ABPchr1

185276794

-
In-frameENST00000542128ENST00000367498KDM3Achr2

86709225

+IVNS1ABPchr1

185276794

-
intron-3CDSENST00000485171ENST00000367498KDM3Achr2

86709225

+IVNS1ABPchr1

185276794

-
intron-5UTRENST00000485171ENST00000392007KDM3Achr2

86709225

+IVNS1ABPchr1

185276794

-
intron-5UTRENST00000485171ENST00000459929KDM3Achr2

86709225

+IVNS1ABPchr1

185276794

-
intron-intronENST00000485171ENST00000367497KDM3Achr2

86709225

+IVNS1ABPchr1

185276794

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409556KDM3Achr286709225+ENST00000367498IVNS1ABPchr1185276794-6269305036546211418
ENST00000312912KDM3Achr286709225+ENST00000367498IVNS1ABPchr1185276794-6231301232745831418
ENST00000409064KDM3Achr286709225+ENST00000367498IVNS1ABPchr1185276794-596227435843141418
ENST00000542128KDM3Achr286709225+ENST00000367498IVNS1ABPchr1185276794-57482529041001366

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409556ENST00000367498KDM3Achr286709225+IVNS1ABPchr1185276794-0.0002160510.99978393
ENST00000312912ENST00000367498KDM3Achr286709225+IVNS1ABPchr1185276794-0.0002016530.99979836
ENST00000409064ENST00000367498KDM3Achr286709225+IVNS1ABPchr1185276794-0.0001442250.99985576
ENST00000542128ENST00000367498KDM3Achr286709225+IVNS1ABPchr1185276794-0.0001368720.99986315

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Fusion Genomic Features for KDM3A-IVNS1ABP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for KDM3A-IVNS1ABP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:86709225/chr1:185276794)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM3Achr2:86709225chr1:185276794ENST00000312912+1726885_8898951322.0MotifNote=LXXLL motif
HgeneKDM3Achr2:86709225chr1:185276794ENST00000409064+1726885_8898951322.0MotifNote=LXXLL motif
HgeneKDM3Achr2:86709225chr1:185276794ENST00000409556+1827885_8898951322.0MotifNote=LXXLL motif
HgeneKDM3Achr2:86709225chr1:185276794ENST00000312912+1726662_6878951322.0Zinc fingerC6-type
HgeneKDM3Achr2:86709225chr1:185276794ENST00000409064+1726662_6878951322.0Zinc fingerC6-type
HgeneKDM3Achr2:86709225chr1:185276794ENST00000409556+1827662_6878951322.0Zinc fingerC6-type
TgeneIVNS1ABPchr2:86709225chr1:185276794ENST00000367498415134_233119643.0DomainNote=BACK
TgeneIVNS1ABPchr2:86709225chr1:185276794ENST00000367498415369_415119643.0RepeatNote=Kelch 1
TgeneIVNS1ABPchr2:86709225chr1:185276794ENST00000367498415416_463119643.0RepeatNote=Kelch 2
TgeneIVNS1ABPchr2:86709225chr1:185276794ENST00000367498415465_512119643.0RepeatNote=Kelch 3
TgeneIVNS1ABPchr2:86709225chr1:185276794ENST00000367498415513_559119643.0RepeatNote=Kelch 4
TgeneIVNS1ABPchr2:86709225chr1:185276794ENST00000367498415560_606119643.0RepeatNote=Kelch 5
TgeneIVNS1ABPchr2:86709225chr1:185276794ENST00000367498415608_642119643.0RepeatNote=Kelch 6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM3Achr2:86709225chr1:185276794ENST00000312912+17261058_12818951322.0DomainJmjC
HgeneKDM3Achr2:86709225chr1:185276794ENST00000409064+17261058_12818951322.0DomainJmjC
HgeneKDM3Achr2:86709225chr1:185276794ENST00000409556+18271058_12818951322.0DomainJmjC
TgeneIVNS1ABPchr2:86709225chr1:185276794ENST0000036749841532_99119643.0DomainBTB


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Fusion Gene Sequence for KDM3A-IVNS1ABP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41761_41761_1_KDM3A-IVNS1ABP_KDM3A_chr2_86709225_ENST00000312912_IVNS1ABP_chr1_185276794_ENST00000367498_length(transcript)=6231nt_BP=3012nt
TAATGGGGGTCGCCCGGGAGTCGGAAGGGGGAGGGGAAAGGGAGGAGGCAGCCAAGGAATTGTTTTTTTCTCTGGCCCCGCCCTCGCCCG
GGGGGCCAATGGTGATGATCTGTTTCCCCCGGAGCCTCGCCCAGCTCCTGTGTTTCAGCCAATGAGCGGCGGAAGCGGCTCCGAGGGGGG
CGGGTCCGGGAGGCTGTGCGTGTCTTGTGAGAGCTCTTGAACCAAGTCAGCGCTGGAGTCGGCTAGGCGGCTGGAAACGGCGGCTGCCGC
CGGTGACTCAGGGAGGCGGGAGGCGGGGGAGGAGCTCTTCCTGCAGGCGTGGAAACCATGGTGCTCACGCTCGGAGAAAGTTGGCCGGTA
TTGGTGGGGAGGAGGTTTCTCAGTCTGTCCGCAGCCGACGGCAGCGATGGCAGCCACGACAGCTGGGACGTGGAGCGCGTCGCCGAGTGG
CCCTGGCTCTCCGGGACCATTCGAGCTGTTTCCCACACCGACGTTACCAAGAAGGATCTGAAGGTGTGTGTGGAATTTGATGGGGAATCT
TGGAGGAAAAGAAGATGGATAGAAGTCTACAGCCTTCTAAGGAGAGCATTTTTAGTAGAACATAATTTGGTTTTAGCTGAACGAAAGTCA
CCTGAAATTTCTGAACGAATTGTACAGTGGCCTGCAATAACGTACAAACCTCTGTTGGACAAAGCTGGTTTGGGATCCATAACTTCTGTT
CGCTTTCTGGGAGATCAACAAAGAGTATTTCTTTCTAAAGACCTTTTGAAGCCTATACAGGATGTAAACAGTCTTCGACTTTCTCTTACG
GATAATCAGATTGTCAGTAAAGAATTTCAAGCTTTGATTGTGAAGCATTTAGATGAAAGCCATCTTTTAAAAGGTGACAAAAACTTAGTT
GGTTCAGAAGTAAAAATTTATAGCTTGGACCCATCTACTCAGTGGTTTTCAGCAACCGTTATAAATGGAAACCCAGCATCAAAAACTCTT
CAAGTCAACTGTGAGGAGATTCCAGCACTGAAAATTGTTGATCCGTCACTGATTCATGTTGAAGTTGTACACGATAACCTTGTGACATGT
GGTAATTCTGCAAGAATTGGAGCTGTAAAACGCAAGTCTTCTGAGAATAATGGAACCCTGGTTTCCAAACAAGCAAAATCTTGCTCTGAG
GCCTCTCCCAGTATGTGTCCTGTGCAGTCTGTACCTACAACAGTTTTTAAGGAGATACTGCTTGGCTGTACTGCGGCAACTCCACCTAGT
AAGGACCCAAGACAGCAAAGTACTCCCCAGGCTGCCAACTCTCCACCTAACCTTGGAGCAAAAATTCCTCAAGGATGTCATAAACAAAGT
TTACCAGAGGAAATTTCTTCCTGTCTAAATACAAAGTCTGAAGCTCTGAGAACAAAACCAGATGTCTGCAAAGCAGGGTTGCTCTCAAAG
TCCTCTCAGATTGGAACTGGAGACTTGAAAATTCTGACTGAGCCAAAAGGCAGCTGTACTCAGCCTAAGACAAACACTGATCAGGAAAAC
AGATTGGAGTCTGTTCCACAAGCATTGACTGGCCTTCCTAAGGAGTGCTTACCTACAAAGGCTTCTTCTAAGGCAGAATTGGAAATTGCC
AATCCTCCTGAACTGCAGAAGCACCTAGAACATGCACCTTCCCCATCGGATGTTTCAAATGCACCAGAAGTGAAAGCAGGTGTCAATAGT
GATAGCCCTAATAACTGTTCAGGAAAAAAGGTAGAACCTTCAGCTTTAGCTTGCCGATCACAGAATTTAAAGGAATCTTCAGTAAAAGTA
GATAATGAAAGCTGTTGTTCAAGAAGCAACAATAAAATCCAGAATGCCCCATCCAGGAAGTCGGTTTTGACAGACCCAGCTAAACTCAAA
AAGCTGCAACAGAGTGGCGAGGCCTTCGTACAGGATGATTCTTGTGTGAACATCGTGGCACAGTTGCCTAAATGCCGAGAGTGTCGCTTG
GACAGTCTCCGCAAGGATAAGGAGCAACAGAAGGACTCACCTGTGTTTTGCCGCTTCTTTCACTTCAGGAGGTTACAATTCAACAAACAT
GGTGTGTTGCGGGTAGAAGGCTTCTTAACACCAAACAAGTATGACAATGAAGCAATTGGCTTGTGGTTACCTTTAACCAAAAACGTTGTG
GGGATTGATTTGGACACAGCAAAGTACATCTTGGCCAACATTGGAGACCACTTCTGTCAAATGGTGATTTCTGAAAAGGAAGCTATGTCA
ACTATTGAGCCACACAGACAGGTTGCTTGGAAGCGAGCTGTCAAAGGTGTTCGAGAAATGTGTGATGTGTGCGACACCACCATCTTCAAC
CTGCACTGGGTGTGTCCTCGGTGTGGGTTTGGAGTATGTGTGGACTGCTACCGGATGAAGAGAAAGAATTGCCAACAGGGTGCTGCTTAC
AAGACTTTCTCTTGGCTAAAATGTGTGAAGAGTCAGATACATGAACCAGAGAACTTAATGCCCACACAGATCATTCCTGGAAAAGCACTC
TATGATGTTGGAGACATTGTTCATTCTGTAAGAGCGAAATGGGGAATAAAGGCAAACTGCCCTTGTTCAAACAGGCAATTCAAACTCTTT
TCAAAGCCAGCCTCAAAGGAAGACCTAAAACAGACTTCTTTAGCTGGAGAAAAACCGACTCTTGGTGCAGTGCTCCAGCAGAATCCCTCA
GTGTTGGAGCCAGCAGCTGTGGGTGGGGAAGCAGCCTCCAAGCCAGCCGGCAGCATGAAGCCTGCCTGTCCAGCCAGCACATCTCCTCTA
AACTGGCTGGCCGACCTAACCAGCGGGAATGTCAACAAGGAAAACAAGGAAAAACAACCAACAATGCCAATTTTAAAGAATGAAATCAAA
TGCCTTCCACCCCTCCCACCTTTAAGCAAATCCAGCACAGTCCTCCATACGTTTAACAGCACAATTTTGACACCCGTAAGCAACAACAAT
TCTGGTTTCCTCCGGAATCTCTTGAATTCTTCTACAGGAAAGGTTTGTGGTGATTATTTACTGTCTAGAATGGATGTTACCAGCTGCATC
TCTTACCGAAATTTTGCAAGTTGTATGGGAGACTCCCGTTTGTTGAATAAGGTTGATGCTTATATTCAGGAGCATTTGTTACAAATTTCT
GAAGAGGAGGAGTTTCTTAAGCTTCCAAGGCTAAAGTTGGAGGTAATGCTTGAAGATAATGTTTGCTTGCCCAGCAATGGCAAATTATAT
ACAAAGGTAATCAACTGGGTGCAGCGTAGCATCTGGGAGAATGGAGACAGTCTGGAAGAGCTGATGGAAGAGGTTCAAACCTTGTACTAC
TCAGCTGATCACAAGCTGCTTGATGGGAACCTACTAGATGGACAGGCTGAGGTGTTTGGCAGTGATGATGACCACATTCAGTTTGTGCAG
AAAAAGCCACCACGTGAGAATGGCCATAAGCAGATAAGTAGCAGTTCAACTGGATGTCTCTCTTCTCCAAATGCTACAGTACAAAGCCCT
AAGCATGAGTGGAAAATCGTTGCTTCAGAAAAGACTTCAAATAACACTTACTTGTGCCTGGCTGTGCTGGATGGTATATTCTGTGTCATT
TTTCTTCATGGGAGAAACAGCCCACAGAGCTCACCAACAAGTACTCCAAAACTAAGTAAGAGTTTAAGCTTTGAGATGCAACAAGATGAG
CTAATCGAAAAGCCCATGTCTCCTATGCAGTACGCACGATCTGGTCTGGGAACAGCAGAGATGAATGGCAAACTCATAGCTGCAGGTGGC
TATAACAGAGAGGAATGTCTTCGAACAGTCGAATGCTATAATCCACATACAGATCACTGGTCCTTTCTTGCTCCCATGAGAACACCAAGA
GCCCGATTTCAAATGGCTGTACTCATGGGCCAGCTCTATGTGGTAGGTGGATCAAATGGCCACTCAGATGACCTGAGTTGTGGAGAGATG
TATGATTCAAACATAGATGACTGGATTCCTGTTCCAGAATTGAGAACTAACCGTTGTAATGCAGGAGTGTGTGCTCTGAATGGAAAGTTA
TACATCGTTGGTGGCTCTGATCCATATGGTCAAAAAGGACTGAAAAATTGTGATGTATTTGATCCTGTAACAAAGTTGTGGACAAGCTGT
GCCCCTCTTAACATTCGGAGACACCAGTCTGCAGTCTGTGAGCTTGGTGGTTATTTGTACATAATCGGAGGTGCAGAATCTTGGAATTGT
CTGAACACAGTAGAACGATACAATCCTGAAAATAATACCTGGACTTTAATTGCACCCATGAATGTGGCTAGGCGAGGAGCTGGAGTGGCT
GTTCTTAATGGAAAACTGTTTGTATGTGGTGGCTTTGATGGTTCTCATGCCATCAGTTGTGTGGAAATGTATGATCCAACTAGAAATGAA
TGGAAGATGATGGGAAATATGACTTCACCAAGGAGCAATGCTGGGATTGCAACTGTAGGGAACACCATTTATGCAGTGGGAGGATTCGAT
GGCAATGAATTTCTGAATACGGTGGAAGTCTATAACCTTGAGTCAAATGAATGGAGCCCCTATACAAAGATTTTCCAGTTTTAACAAATT
TAAGACCCTCTCAAACTAACAGGCTTAGTGATGTAATTATGGTTAGTAGAGGTACACTTGTGAATAAAGAGGGTGGGTGGGTATAGATGT
TGCTAACAGCAACACAAAGCTTTTGCATATTGCATACTATTAAACATGCTGTACATACTTTTTGGGTTTATTTGGAAAGGAATGCAAAGA
TGAAGGTCTGTTTTGTGTACTTTTAAGACTTTGGTTATTTTACTTTTTGGAAAAGAATAAACCAAGAATTGATTGGGCACATCATTTCAA
GAAGTCCCCTCTCCTCCACATTTGTTTTGCCAATTTGCACATTAAATGACTCTTCCCTCAAATGTGTACTATGGGGTAAAAGGGGTAGGG
TTTAAAGATGTAGACAGTTGGGTTTTTTAAGGGCCCTTTTTCAATAACTGGAACACTCTATAACAAAGGATACTTATTTAAATAGATGAC
ATTGACTATTTTTGTTTTTATTAAAAGGAAGCTTACATGCCTACCAATATTTAATCTTTTATGATTGCCTTTTTATAACTTTTTATATTC
TCAGCAGAGTGCTTTACCAATTGAAGTAAAATGTGGCAGGCTGGAGTTATTGAAGCAGAGTGGCAGTCTTCAGTTTGCAGAGTAGGGGTC
TGTCTTTTAAACTCTGAGTGCAAACTTCAGAGTTCTTGCCTTGGCTGCAGTTTTTTTCCTTCAAGAATGCAGTACTAACATTTATTTGAG
TGGAGTTACTGAACAGTAACATAGCTGTGATTTTTGGTATTTGAAACACTGGTTTTAAATATTTTGACTTGTTGAGGGTATGTTTTATAT
AGCAAGACATTATATAGCAGTAAAAAATGGTGTTTTATCTTCTATATAATTCCTGTTTTTATTATTAACAAAACAGTCCTAAATAGCAGC
CCTCAATTGTGAAAAAATTTACTTTAAACTACATTAGGTTGTGAATGCAGGTTTTATCAGAACTATGTTTTTGTTCAGTTTATCTGTTCA
TATGGATAAATATTGGTTGGGATGACTTGGTGTCTAATGTGTAGTGCTACACACCTAACTTATGGGGCCAAAATAGCATGTCCTAATGCT
TGCTGCTGATTTAAACACATTAAAGGTACTTTGCAGGAAATCCTTGCACCATGGGATTAATATCCAATTGCTGCTTGTACACTCATTCAT
TACTAAAAGTTTTGAGAAATTTTTTTTTCCAGTAATGAGCTTAAGAAATTTGTGGAAAATAACTCACCTGGCATCTTACATCTGAAATAA
GGAATGATATAAGGTTTTTTTTTCTCACAGAAGATGAAGCACACAGGAACCTAATGGGCCAACTGGGATGAGGTGACTATTCTGAGATGA
CTATTCAGTGGCTAACTTGGGTTAGGAAGAAAATAATTAGGTATTTTCTCCAAATGTTCACTGGTACTCTGCCACTTTATTTCTCTCATC
TGTTACACAAAGAACCACCAGGAAAGCAAATCAGTTTGGTTGGTAACTCTGTAATTCCTAACTATCACTGGTTTGGTTCTGGACTAAAAC
TACATTGACAGATTGAATTTGCCTAATATGATGACTGTTTTTAATATGGATCTGTATGTGTTCTATTCAGCACAAGGAAATAAAATTTTA

>41761_41761_1_KDM3A-IVNS1ABP_KDM3A_chr2_86709225_ENST00000312912_IVNS1ABP_chr1_185276794_ENST00000367498_length(amino acids)=1418AA_BP=880
MVLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWLSGTIRAVSHTDVTKKDLKVCVEFDGESWRKRRWIEVYSLLRRAFLV
EHNLVLAERKSPEISERIVQWPAITYKPLLDKAGLGSITSVRFLGDQQRVFLSKDLLKPIQDVNSLRLSLTDNQIVSKEFQALIVKHLDE
SHLLKGDKNLVGSEVKIYSLDPSTQWFSATVINGNPASKTLQVNCEEIPALKIVDPSLIHVEVVHDNLVTCGNSARIGAVKRKSSENNGT
LVSKQAKSCSEASPSMCPVQSVPTTVFKEILLGCTAATPPSKDPRQQSTPQAANSPPNLGAKIPQGCHKQSLPEEISSCLNTKSEALRTK
PDVCKAGLLSKSSQIGTGDLKILTEPKGSCTQPKTNTDQENRLESVPQALTGLPKECLPTKASSKAELEIANPPELQKHLEHAPSPSDVS
NAPEVKAGVNSDSPNNCSGKKVEPSALACRSQNLKESSVKVDNESCCSRSNNKIQNAPSRKSVLTDPAKLKKLQQSGEAFVQDDSCVNIV
AQLPKCRECRLDSLRKDKEQQKDSPVFCRFFHFRRLQFNKHGVLRVEGFLTPNKYDNEAIGLWLPLTKNVVGIDLDTAKYILANIGDHFC
QMVISEKEAMSTIEPHRQVAWKRAVKGVREMCDVCDTTIFNLHWVCPRCGFGVCVDCYRMKRKNCQQGAAYKTFSWLKCVKSQIHEPENL
MPTQIIPGKALYDVGDIVHSVRAKWGIKANCPCSNRQFKLFSKPASKEDLKQTSLAGEKPTLGAVLQQNPSVLEPAAVGGEAASKPAGSM
KPACPASTSPLNWLADLTSGNVNKENKEKQPTMPILKNEIKCLPPLPPLSKSSTVLHTFNSTILTPVSNNNSGFLRNLLNSSTGKVCGDY
LLSRMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLEDNVCLPSNGKLYTKVINWVQRSIWENGDSLE
ELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSDDDHIQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLC
LAVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDH
WSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDV
FDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAIS

--------------------------------------------------------------
>41761_41761_2_KDM3A-IVNS1ABP_KDM3A_chr2_86709225_ENST00000409064_IVNS1ABP_chr1_185276794_ENST00000367498_length(transcript)=5962nt_BP=2743nt
CTCGGCTGCGGGGAGAGGGGAGAGAAAGGGAGGAGCTCTTCCTGCAGGCGTGGAAACCATGGTGCTCACGCTCGGAGAAAGTTGGCCGGT
ATTGGTGGGGAGGAGGTTTCTCAGTCTGTCCGCAGCCGACGGCAGCGATGGCAGCCACGACAGCTGGGACGTGGAGCGCGTCGCCGAGTG
GCCCTGGCTCTCCGGGACCATTCGAGCTGTTTCCCACACCGACGTTACCAAGAAGGATCTGAAGGTGTGTGTGGAATTTGATGGGGAATC
TTGGAGGAAAAGAAGATGGATAGAAGTCTACAGCCTTCTAAGGAGAGCATTTTTAGTAGAACATAATTTGGTTTTAGCTGAACGAAAGTC
ACCTGAAATTTCTGAACGAATTGTACAGTGGCCTGCAATAACGTACAAACCTCTGTTGGACAAAGCTGGTTTGGGATCCATAACTTCTGT
TCGCTTTCTGGGAGATCAACAAAGAGTATTTCTTTCTAAAGACCTTTTGAAGCCTATACAGGATGTAAACAGTCTTCGACTTTCTCTTAC
GGATAATCAGATTGTCAGTAAAGAATTTCAAGCTTTGATTGTGAAGCATTTAGATGAAAGCCATCTTTTAAAAGGTGACAAAAACTTAGT
TGGTTCAGAAGTAAAAATTTATAGCTTGGACCCATCTACTCAGTGGTTTTCAGCAACCGTTATAAATGGAAACCCAGCATCAAAAACTCT
TCAAGTCAACTGTGAGGAGATTCCAGCACTGAAAATTGTTGATCCGTCACTGATTCATGTTGAAGTTGTACACGATAACCTTGTGACATG
TGGTAATTCTGCAAGAATTGGAGCTGTAAAACGCAAGTCTTCTGAGAATAATGGAACCCTGGTTTCCAAACAAGCAAAATCTTGCTCTGA
GGCCTCTCCCAGTATGTGTCCTGTGCAGTCTGTACCTACAACAGTTTTTAAGGAGATACTGCTTGGCTGTACTGCGGCAACTCCACCTAG
TAAGGACCCAAGACAGCAAAGTACTCCCCAGGCTGCCAACTCTCCACCTAACCTTGGAGCAAAAATTCCTCAAGGATGTCATAAACAAAG
TTTACCAGAGGAAATTTCTTCCTGTCTAAATACAAAGTCTGAAGCTCTGAGAACAAAACCAGATGTCTGCAAAGCAGGGTTGCTCTCAAA
GTCCTCTCAGATTGGAACTGGAGACTTGAAAATTCTGACTGAGCCAAAAGGCAGCTGTACTCAGCCTAAGACAAACACTGATCAGGAAAA
CAGATTGGAGTCTGTTCCACAAGCATTGACTGGCCTTCCTAAGGAGTGCTTACCTACAAAGGCTTCTTCTAAGGCAGAATTGGAAATTGC
CAATCCTCCTGAACTGCAGAAGCACCTAGAACATGCACCTTCCCCATCGGATGTTTCAAATGCACCAGAAGTGAAAGCAGGTGTCAATAG
TGATAGCCCTAATAACTGTTCAGGAAAAAAGGTAGAACCTTCAGCTTTAGCTTGCCGATCACAGAATTTAAAGGAATCTTCAGTAAAAGT
AGATAATGAAAGCTGTTGTTCAAGAAGCAACAATAAAATCCAGAATGCCCCATCCAGGAAGTCGGTTTTGACAGACCCAGCTAAACTCAA
AAAGCTGCAACAGAGTGGCGAGGCCTTCGTACAGGATGATTCTTGTGTGAACATCGTGGCACAGTTGCCTAAATGCCGAGAGTGTCGCTT
GGACAGTCTCCGCAAGGATAAGGAGCAACAGAAGGACTCACCTGTGTTTTGCCGCTTCTTTCACTTCAGGAGGTTACAATTCAACAAACA
TGGTGTGTTGCGGGTAGAAGGCTTCTTAACACCAAACAAGTATGACAATGAAGCAATTGGCTTGTGGTTACCTTTAACCAAAAACGTTGT
GGGGATTGATTTGGACACAGCAAAGTACATCTTGGCCAACATTGGAGACCACTTCTGTCAAATGGTGATTTCTGAAAAGGAAGCTATGTC
AACTATTGAGCCACACAGACAGGTTGCTTGGAAGCGAGCTGTCAAAGGTGTTCGAGAAATGTGTGATGTGTGCGACACCACCATCTTCAA
CCTGCACTGGGTGTGTCCTCGGTGTGGGTTTGGAGTATGTGTGGACTGCTACCGGATGAAGAGAAAGAATTGCCAACAGGGTGCTGCTTA
CAAGACTTTCTCTTGGCTAAAATGTGTGAAGAGTCAGATACATGAACCAGAGAACTTAATGCCCACACAGATCATTCCTGGAAAAGCACT
CTATGATGTTGGAGACATTGTTCATTCTGTAAGAGCGAAATGGGGAATAAAGGCAAACTGCCCTTGTTCAAACAGGCAATTCAAACTCTT
TTCAAAGCCAGCCTCAAAGGAAGACCTAAAACAGACTTCTTTAGCTGGAGAAAAACCGACTCTTGGTGCAGTGCTCCAGCAGAATCCCTC
AGTGTTGGAGCCAGCAGCTGTGGGTGGGGAAGCAGCCTCCAAGCCAGCCGGCAGCATGAAGCCTGCCTGTCCAGCCAGCACATCTCCTCT
AAACTGGCTGGCCGACCTAACCAGCGGGAATGTCAACAAGGAAAACAAGGAAAAACAACCAACAATGCCAATTTTAAAGAATGAAATCAA
ATGCCTTCCACCCCTCCCACCTTTAAGCAAATCCAGCACAGTCCTCCATACGTTTAACAGCACAATTTTGACACCCGTAAGCAACAACAA
TTCTGGTTTCCTCCGGAATCTCTTGAATTCTTCTACAGGAAAGGTTTGTGGTGATTATTTACTGTCTAGAATGGATGTTACCAGCTGCAT
CTCTTACCGAAATTTTGCAAGTTGTATGGGAGACTCCCGTTTGTTGAATAAGGTTGATGCTTATATTCAGGAGCATTTGTTACAAATTTC
TGAAGAGGAGGAGTTTCTTAAGCTTCCAAGGCTAAAGTTGGAGGTAATGCTTGAAGATAATGTTTGCTTGCCCAGCAATGGCAAATTATA
TACAAAGGTAATCAACTGGGTGCAGCGTAGCATCTGGGAGAATGGAGACAGTCTGGAAGAGCTGATGGAAGAGGTTCAAACCTTGTACTA
CTCAGCTGATCACAAGCTGCTTGATGGGAACCTACTAGATGGACAGGCTGAGGTGTTTGGCAGTGATGATGACCACATTCAGTTTGTGCA
GAAAAAGCCACCACGTGAGAATGGCCATAAGCAGATAAGTAGCAGTTCAACTGGATGTCTCTCTTCTCCAAATGCTACAGTACAAAGCCC
TAAGCATGAGTGGAAAATCGTTGCTTCAGAAAAGACTTCAAATAACACTTACTTGTGCCTGGCTGTGCTGGATGGTATATTCTGTGTCAT
TTTTCTTCATGGGAGAAACAGCCCACAGAGCTCACCAACAAGTACTCCAAAACTAAGTAAGAGTTTAAGCTTTGAGATGCAACAAGATGA
GCTAATCGAAAAGCCCATGTCTCCTATGCAGTACGCACGATCTGGTCTGGGAACAGCAGAGATGAATGGCAAACTCATAGCTGCAGGTGG
CTATAACAGAGAGGAATGTCTTCGAACAGTCGAATGCTATAATCCACATACAGATCACTGGTCCTTTCTTGCTCCCATGAGAACACCAAG
AGCCCGATTTCAAATGGCTGTACTCATGGGCCAGCTCTATGTGGTAGGTGGATCAAATGGCCACTCAGATGACCTGAGTTGTGGAGAGAT
GTATGATTCAAACATAGATGACTGGATTCCTGTTCCAGAATTGAGAACTAACCGTTGTAATGCAGGAGTGTGTGCTCTGAATGGAAAGTT
ATACATCGTTGGTGGCTCTGATCCATATGGTCAAAAAGGACTGAAAAATTGTGATGTATTTGATCCTGTAACAAAGTTGTGGACAAGCTG
TGCCCCTCTTAACATTCGGAGACACCAGTCTGCAGTCTGTGAGCTTGGTGGTTATTTGTACATAATCGGAGGTGCAGAATCTTGGAATTG
TCTGAACACAGTAGAACGATACAATCCTGAAAATAATACCTGGACTTTAATTGCACCCATGAATGTGGCTAGGCGAGGAGCTGGAGTGGC
TGTTCTTAATGGAAAACTGTTTGTATGTGGTGGCTTTGATGGTTCTCATGCCATCAGTTGTGTGGAAATGTATGATCCAACTAGAAATGA
ATGGAAGATGATGGGAAATATGACTTCACCAAGGAGCAATGCTGGGATTGCAACTGTAGGGAACACCATTTATGCAGTGGGAGGATTCGA
TGGCAATGAATTTCTGAATACGGTGGAAGTCTATAACCTTGAGTCAAATGAATGGAGCCCCTATACAAAGATTTTCCAGTTTTAACAAAT
TTAAGACCCTCTCAAACTAACAGGCTTAGTGATGTAATTATGGTTAGTAGAGGTACACTTGTGAATAAAGAGGGTGGGTGGGTATAGATG
TTGCTAACAGCAACACAAAGCTTTTGCATATTGCATACTATTAAACATGCTGTACATACTTTTTGGGTTTATTTGGAAAGGAATGCAAAG
ATGAAGGTCTGTTTTGTGTACTTTTAAGACTTTGGTTATTTTACTTTTTGGAAAAGAATAAACCAAGAATTGATTGGGCACATCATTTCA
AGAAGTCCCCTCTCCTCCACATTTGTTTTGCCAATTTGCACATTAAATGACTCTTCCCTCAAATGTGTACTATGGGGTAAAAGGGGTAGG
GTTTAAAGATGTAGACAGTTGGGTTTTTTAAGGGCCCTTTTTCAATAACTGGAACACTCTATAACAAAGGATACTTATTTAAATAGATGA
CATTGACTATTTTTGTTTTTATTAAAAGGAAGCTTACATGCCTACCAATATTTAATCTTTTATGATTGCCTTTTTATAACTTTTTATATT
CTCAGCAGAGTGCTTTACCAATTGAAGTAAAATGTGGCAGGCTGGAGTTATTGAAGCAGAGTGGCAGTCTTCAGTTTGCAGAGTAGGGGT
CTGTCTTTTAAACTCTGAGTGCAAACTTCAGAGTTCTTGCCTTGGCTGCAGTTTTTTTCCTTCAAGAATGCAGTACTAACATTTATTTGA
GTGGAGTTACTGAACAGTAACATAGCTGTGATTTTTGGTATTTGAAACACTGGTTTTAAATATTTTGACTTGTTGAGGGTATGTTTTATA
TAGCAAGACATTATATAGCAGTAAAAAATGGTGTTTTATCTTCTATATAATTCCTGTTTTTATTATTAACAAAACAGTCCTAAATAGCAG
CCCTCAATTGTGAAAAAATTTACTTTAAACTACATTAGGTTGTGAATGCAGGTTTTATCAGAACTATGTTTTTGTTCAGTTTATCTGTTC
ATATGGATAAATATTGGTTGGGATGACTTGGTGTCTAATGTGTAGTGCTACACACCTAACTTATGGGGCCAAAATAGCATGTCCTAATGC
TTGCTGCTGATTTAAACACATTAAAGGTACTTTGCAGGAAATCCTTGCACCATGGGATTAATATCCAATTGCTGCTTGTACACTCATTCA
TTACTAAAAGTTTTGAGAAATTTTTTTTTCCAGTAATGAGCTTAAGAAATTTGTGGAAAATAACTCACCTGGCATCTTACATCTGAAATA
AGGAATGATATAAGGTTTTTTTTTCTCACAGAAGATGAAGCACACAGGAACCTAATGGGCCAACTGGGATGAGGTGACTATTCTGAGATG
ACTATTCAGTGGCTAACTTGGGTTAGGAAGAAAATAATTAGGTATTTTCTCCAAATGTTCACTGGTACTCTGCCACTTTATTTCTCTCAT
CTGTTACACAAAGAACCACCAGGAAAGCAAATCAGTTTGGTTGGTAACTCTGTAATTCCTAACTATCACTGGTTTGGTTCTGGACTAAAA
CTACATTGACAGATTGAATTTGCCTAATATGATGACTGTTTTTAATATGGATCTGTATGTGTTCTATTCAGCACAAGGAAATAAAATTTT

>41761_41761_2_KDM3A-IVNS1ABP_KDM3A_chr2_86709225_ENST00000409064_IVNS1ABP_chr1_185276794_ENST00000367498_length(amino acids)=1418AA_BP=880
MVLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWLSGTIRAVSHTDVTKKDLKVCVEFDGESWRKRRWIEVYSLLRRAFLV
EHNLVLAERKSPEISERIVQWPAITYKPLLDKAGLGSITSVRFLGDQQRVFLSKDLLKPIQDVNSLRLSLTDNQIVSKEFQALIVKHLDE
SHLLKGDKNLVGSEVKIYSLDPSTQWFSATVINGNPASKTLQVNCEEIPALKIVDPSLIHVEVVHDNLVTCGNSARIGAVKRKSSENNGT
LVSKQAKSCSEASPSMCPVQSVPTTVFKEILLGCTAATPPSKDPRQQSTPQAANSPPNLGAKIPQGCHKQSLPEEISSCLNTKSEALRTK
PDVCKAGLLSKSSQIGTGDLKILTEPKGSCTQPKTNTDQENRLESVPQALTGLPKECLPTKASSKAELEIANPPELQKHLEHAPSPSDVS
NAPEVKAGVNSDSPNNCSGKKVEPSALACRSQNLKESSVKVDNESCCSRSNNKIQNAPSRKSVLTDPAKLKKLQQSGEAFVQDDSCVNIV
AQLPKCRECRLDSLRKDKEQQKDSPVFCRFFHFRRLQFNKHGVLRVEGFLTPNKYDNEAIGLWLPLTKNVVGIDLDTAKYILANIGDHFC
QMVISEKEAMSTIEPHRQVAWKRAVKGVREMCDVCDTTIFNLHWVCPRCGFGVCVDCYRMKRKNCQQGAAYKTFSWLKCVKSQIHEPENL
MPTQIIPGKALYDVGDIVHSVRAKWGIKANCPCSNRQFKLFSKPASKEDLKQTSLAGEKPTLGAVLQQNPSVLEPAAVGGEAASKPAGSM
KPACPASTSPLNWLADLTSGNVNKENKEKQPTMPILKNEIKCLPPLPPLSKSSTVLHTFNSTILTPVSNNNSGFLRNLLNSSTGKVCGDY
LLSRMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLEDNVCLPSNGKLYTKVINWVQRSIWENGDSLE
ELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSDDDHIQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLC
LAVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDH
WSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDV
FDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAIS

--------------------------------------------------------------
>41761_41761_3_KDM3A-IVNS1ABP_KDM3A_chr2_86709225_ENST00000409556_IVNS1ABP_chr1_185276794_ENST00000367498_length(transcript)=6269nt_BP=3050nt
ACTATCGCTCCTCCCTCTAGCTGAGTACGCCTGAAACCGCACGTTCTCTTCCCTGCCCTCCCCCGCTAACCCTGCACCGCCCTCACCCTT
TCCTGTGAGATTCTTCCGCCAAGTGGAAGGCTCATCTTCGGTCGACAGCCTACGCGGTTGAAGAACAATCCACCTCGCCCAGCTCCTGTG
TTTCAGCCAATGAGCGGCGGAAGCGGCTCCGAGGGGGGCGGGTCCGGGAGGCTGTGCGTGTCTTGTGAGAGCTCTTGAACCAAGTCAGCG
CTGGAGTCGGCTAGGCGGCTGGAAACGGCGGCTGCCGCCGGTGACTCAGGGAGGCGGGAGGCGGGGGAGGAGCTCTTCCTGCAGGCGTGG
AAACCATGGTGCTCACGCTCGGAGAAAGTTGGCCGGTATTGGTGGGGAGGAGGTTTCTCAGTCTGTCCGCAGCCGACGGCAGCGATGGCA
GCCACGACAGCTGGGACGTGGAGCGCGTCGCCGAGTGGCCCTGGCTCTCCGGGACCATTCGAGCTGTTTCCCACACCGACGTTACCAAGA
AGGATCTGAAGGTGTGTGTGGAATTTGATGGGGAATCTTGGAGGAAAAGAAGATGGATAGAAGTCTACAGCCTTCTAAGGAGAGCATTTT
TAGTAGAACATAATTTGGTTTTAGCTGAACGAAAGTCACCTGAAATTTCTGAACGAATTGTACAGTGGCCTGCAATAACGTACAAACCTC
TGTTGGACAAAGCTGGTTTGGGATCCATAACTTCTGTTCGCTTTCTGGGAGATCAACAAAGAGTATTTCTTTCTAAAGACCTTTTGAAGC
CTATACAGGATGTAAACAGTCTTCGACTTTCTCTTACGGATAATCAGATTGTCAGTAAAGAATTTCAAGCTTTGATTGTGAAGCATTTAG
ATGAAAGCCATCTTTTAAAAGGTGACAAAAACTTAGTTGGTTCAGAAGTAAAAATTTATAGCTTGGACCCATCTACTCAGTGGTTTTCAG
CAACCGTTATAAATGGAAACCCAGCATCAAAAACTCTTCAAGTCAACTGTGAGGAGATTCCAGCACTGAAAATTGTTGATCCGTCACTGA
TTCATGTTGAAGTTGTACACGATAACCTTGTGACATGTGGTAATTCTGCAAGAATTGGAGCTGTAAAACGCAAGTCTTCTGAGAATAATG
GAACCCTGGTTTCCAAACAAGCAAAATCTTGCTCTGAGGCCTCTCCCAGTATGTGTCCTGTGCAGTCTGTACCTACAACAGTTTTTAAGG
AGATACTGCTTGGCTGTACTGCGGCAACTCCACCTAGTAAGGACCCAAGACAGCAAAGTACTCCCCAGGCTGCCAACTCTCCACCTAACC
TTGGAGCAAAAATTCCTCAAGGATGTCATAAACAAAGTTTACCAGAGGAAATTTCTTCCTGTCTAAATACAAAGTCTGAAGCTCTGAGAA
CAAAACCAGATGTCTGCAAAGCAGGGTTGCTCTCAAAGTCCTCTCAGATTGGAACTGGAGACTTGAAAATTCTGACTGAGCCAAAAGGCA
GCTGTACTCAGCCTAAGACAAACACTGATCAGGAAAACAGATTGGAGTCTGTTCCACAAGCATTGACTGGCCTTCCTAAGGAGTGCTTAC
CTACAAAGGCTTCTTCTAAGGCAGAATTGGAAATTGCCAATCCTCCTGAACTGCAGAAGCACCTAGAACATGCACCTTCCCCATCGGATG
TTTCAAATGCACCAGAAGTGAAAGCAGGTGTCAATAGTGATAGCCCTAATAACTGTTCAGGAAAAAAGGTAGAACCTTCAGCTTTAGCTT
GCCGATCACAGAATTTAAAGGAATCTTCAGTAAAAGTAGATAATGAAAGCTGTTGTTCAAGAAGCAACAATAAAATCCAGAATGCCCCAT
CCAGGAAGTCGGTTTTGACAGACCCAGCTAAACTCAAAAAGCTGCAACAGAGTGGCGAGGCCTTCGTACAGGATGATTCTTGTGTGAACA
TCGTGGCACAGTTGCCTAAATGCCGAGAGTGTCGCTTGGACAGTCTCCGCAAGGATAAGGAGCAACAGAAGGACTCACCTGTGTTTTGCC
GCTTCTTTCACTTCAGGAGGTTACAATTCAACAAACATGGTGTGTTGCGGGTAGAAGGCTTCTTAACACCAAACAAGTATGACAATGAAG
CAATTGGCTTGTGGTTACCTTTAACCAAAAACGTTGTGGGGATTGATTTGGACACAGCAAAGTACATCTTGGCCAACATTGGAGACCACT
TCTGTCAAATGGTGATTTCTGAAAAGGAAGCTATGTCAACTATTGAGCCACACAGACAGGTTGCTTGGAAGCGAGCTGTCAAAGGTGTTC
GAGAAATGTGTGATGTGTGCGACACCACCATCTTCAACCTGCACTGGGTGTGTCCTCGGTGTGGGTTTGGAGTATGTGTGGACTGCTACC
GGATGAAGAGAAAGAATTGCCAACAGGGTGCTGCTTACAAGACTTTCTCTTGGCTAAAATGTGTGAAGAGTCAGATACATGAACCAGAGA
ACTTAATGCCCACACAGATCATTCCTGGAAAAGCACTCTATGATGTTGGAGACATTGTTCATTCTGTAAGAGCGAAATGGGGAATAAAGG
CAAACTGCCCTTGTTCAAACAGGCAATTCAAACTCTTTTCAAAGCCAGCCTCAAAGGAAGACCTAAAACAGACTTCTTTAGCTGGAGAAA
AACCGACTCTTGGTGCAGTGCTCCAGCAGAATCCCTCAGTGTTGGAGCCAGCAGCTGTGGGTGGGGAAGCAGCCTCCAAGCCAGCCGGCA
GCATGAAGCCTGCCTGTCCAGCCAGCACATCTCCTCTAAACTGGCTGGCCGACCTAACCAGCGGGAATGTCAACAAGGAAAACAAGGAAA
AACAACCAACAATGCCAATTTTAAAGAATGAAATCAAATGCCTTCCACCCCTCCCACCTTTAAGCAAATCCAGCACAGTCCTCCATACGT
TTAACAGCACAATTTTGACACCCGTAAGCAACAACAATTCTGGTTTCCTCCGGAATCTCTTGAATTCTTCTACAGGAAAGGTTTGTGGTG
ATTATTTACTGTCTAGAATGGATGTTACCAGCTGCATCTCTTACCGAAATTTTGCAAGTTGTATGGGAGACTCCCGTTTGTTGAATAAGG
TTGATGCTTATATTCAGGAGCATTTGTTACAAATTTCTGAAGAGGAGGAGTTTCTTAAGCTTCCAAGGCTAAAGTTGGAGGTAATGCTTG
AAGATAATGTTTGCTTGCCCAGCAATGGCAAATTATATACAAAGGTAATCAACTGGGTGCAGCGTAGCATCTGGGAGAATGGAGACAGTC
TGGAAGAGCTGATGGAAGAGGTTCAAACCTTGTACTACTCAGCTGATCACAAGCTGCTTGATGGGAACCTACTAGATGGACAGGCTGAGG
TGTTTGGCAGTGATGATGACCACATTCAGTTTGTGCAGAAAAAGCCACCACGTGAGAATGGCCATAAGCAGATAAGTAGCAGTTCAACTG
GATGTCTCTCTTCTCCAAATGCTACAGTACAAAGCCCTAAGCATGAGTGGAAAATCGTTGCTTCAGAAAAGACTTCAAATAACACTTACT
TGTGCCTGGCTGTGCTGGATGGTATATTCTGTGTCATTTTTCTTCATGGGAGAAACAGCCCACAGAGCTCACCAACAAGTACTCCAAAAC
TAAGTAAGAGTTTAAGCTTTGAGATGCAACAAGATGAGCTAATCGAAAAGCCCATGTCTCCTATGCAGTACGCACGATCTGGTCTGGGAA
CAGCAGAGATGAATGGCAAACTCATAGCTGCAGGTGGCTATAACAGAGAGGAATGTCTTCGAACAGTCGAATGCTATAATCCACATACAG
ATCACTGGTCCTTTCTTGCTCCCATGAGAACACCAAGAGCCCGATTTCAAATGGCTGTACTCATGGGCCAGCTCTATGTGGTAGGTGGAT
CAAATGGCCACTCAGATGACCTGAGTTGTGGAGAGATGTATGATTCAAACATAGATGACTGGATTCCTGTTCCAGAATTGAGAACTAACC
GTTGTAATGCAGGAGTGTGTGCTCTGAATGGAAAGTTATACATCGTTGGTGGCTCTGATCCATATGGTCAAAAAGGACTGAAAAATTGTG
ATGTATTTGATCCTGTAACAAAGTTGTGGACAAGCTGTGCCCCTCTTAACATTCGGAGACACCAGTCTGCAGTCTGTGAGCTTGGTGGTT
ATTTGTACATAATCGGAGGTGCAGAATCTTGGAATTGTCTGAACACAGTAGAACGATACAATCCTGAAAATAATACCTGGACTTTAATTG
CACCCATGAATGTGGCTAGGCGAGGAGCTGGAGTGGCTGTTCTTAATGGAAAACTGTTTGTATGTGGTGGCTTTGATGGTTCTCATGCCA
TCAGTTGTGTGGAAATGTATGATCCAACTAGAAATGAATGGAAGATGATGGGAAATATGACTTCACCAAGGAGCAATGCTGGGATTGCAA
CTGTAGGGAACACCATTTATGCAGTGGGAGGATTCGATGGCAATGAATTTCTGAATACGGTGGAAGTCTATAACCTTGAGTCAAATGAAT
GGAGCCCCTATACAAAGATTTTCCAGTTTTAACAAATTTAAGACCCTCTCAAACTAACAGGCTTAGTGATGTAATTATGGTTAGTAGAGG
TACACTTGTGAATAAAGAGGGTGGGTGGGTATAGATGTTGCTAACAGCAACACAAAGCTTTTGCATATTGCATACTATTAAACATGCTGT
ACATACTTTTTGGGTTTATTTGGAAAGGAATGCAAAGATGAAGGTCTGTTTTGTGTACTTTTAAGACTTTGGTTATTTTACTTTTTGGAA
AAGAATAAACCAAGAATTGATTGGGCACATCATTTCAAGAAGTCCCCTCTCCTCCACATTTGTTTTGCCAATTTGCACATTAAATGACTC
TTCCCTCAAATGTGTACTATGGGGTAAAAGGGGTAGGGTTTAAAGATGTAGACAGTTGGGTTTTTTAAGGGCCCTTTTTCAATAACTGGA
ACACTCTATAACAAAGGATACTTATTTAAATAGATGACATTGACTATTTTTGTTTTTATTAAAAGGAAGCTTACATGCCTACCAATATTT
AATCTTTTATGATTGCCTTTTTATAACTTTTTATATTCTCAGCAGAGTGCTTTACCAATTGAAGTAAAATGTGGCAGGCTGGAGTTATTG
AAGCAGAGTGGCAGTCTTCAGTTTGCAGAGTAGGGGTCTGTCTTTTAAACTCTGAGTGCAAACTTCAGAGTTCTTGCCTTGGCTGCAGTT
TTTTTCCTTCAAGAATGCAGTACTAACATTTATTTGAGTGGAGTTACTGAACAGTAACATAGCTGTGATTTTTGGTATTTGAAACACTGG
TTTTAAATATTTTGACTTGTTGAGGGTATGTTTTATATAGCAAGACATTATATAGCAGTAAAAAATGGTGTTTTATCTTCTATATAATTC
CTGTTTTTATTATTAACAAAACAGTCCTAAATAGCAGCCCTCAATTGTGAAAAAATTTACTTTAAACTACATTAGGTTGTGAATGCAGGT
TTTATCAGAACTATGTTTTTGTTCAGTTTATCTGTTCATATGGATAAATATTGGTTGGGATGACTTGGTGTCTAATGTGTAGTGCTACAC
ACCTAACTTATGGGGCCAAAATAGCATGTCCTAATGCTTGCTGCTGATTTAAACACATTAAAGGTACTTTGCAGGAAATCCTTGCACCAT
GGGATTAATATCCAATTGCTGCTTGTACACTCATTCATTACTAAAAGTTTTGAGAAATTTTTTTTTCCAGTAATGAGCTTAAGAAATTTG
TGGAAAATAACTCACCTGGCATCTTACATCTGAAATAAGGAATGATATAAGGTTTTTTTTTCTCACAGAAGATGAAGCACACAGGAACCT
AATGGGCCAACTGGGATGAGGTGACTATTCTGAGATGACTATTCAGTGGCTAACTTGGGTTAGGAAGAAAATAATTAGGTATTTTCTCCA
AATGTTCACTGGTACTCTGCCACTTTATTTCTCTCATCTGTTACACAAAGAACCACCAGGAAAGCAAATCAGTTTGGTTGGTAACTCTGT
AATTCCTAACTATCACTGGTTTGGTTCTGGACTAAAACTACATTGACAGATTGAATTTGCCTAATATGATGACTGTTTTTAATATGGATC

>41761_41761_3_KDM3A-IVNS1ABP_KDM3A_chr2_86709225_ENST00000409556_IVNS1ABP_chr1_185276794_ENST00000367498_length(amino acids)=1418AA_BP=880
MVLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWLSGTIRAVSHTDVTKKDLKVCVEFDGESWRKRRWIEVYSLLRRAFLV
EHNLVLAERKSPEISERIVQWPAITYKPLLDKAGLGSITSVRFLGDQQRVFLSKDLLKPIQDVNSLRLSLTDNQIVSKEFQALIVKHLDE
SHLLKGDKNLVGSEVKIYSLDPSTQWFSATVINGNPASKTLQVNCEEIPALKIVDPSLIHVEVVHDNLVTCGNSARIGAVKRKSSENNGT
LVSKQAKSCSEASPSMCPVQSVPTTVFKEILLGCTAATPPSKDPRQQSTPQAANSPPNLGAKIPQGCHKQSLPEEISSCLNTKSEALRTK
PDVCKAGLLSKSSQIGTGDLKILTEPKGSCTQPKTNTDQENRLESVPQALTGLPKECLPTKASSKAELEIANPPELQKHLEHAPSPSDVS
NAPEVKAGVNSDSPNNCSGKKVEPSALACRSQNLKESSVKVDNESCCSRSNNKIQNAPSRKSVLTDPAKLKKLQQSGEAFVQDDSCVNIV
AQLPKCRECRLDSLRKDKEQQKDSPVFCRFFHFRRLQFNKHGVLRVEGFLTPNKYDNEAIGLWLPLTKNVVGIDLDTAKYILANIGDHFC
QMVISEKEAMSTIEPHRQVAWKRAVKGVREMCDVCDTTIFNLHWVCPRCGFGVCVDCYRMKRKNCQQGAAYKTFSWLKCVKSQIHEPENL
MPTQIIPGKALYDVGDIVHSVRAKWGIKANCPCSNRQFKLFSKPASKEDLKQTSLAGEKPTLGAVLQQNPSVLEPAAVGGEAASKPAGSM
KPACPASTSPLNWLADLTSGNVNKENKEKQPTMPILKNEIKCLPPLPPLSKSSTVLHTFNSTILTPVSNNNSGFLRNLLNSSTGKVCGDY
LLSRMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLEDNVCLPSNGKLYTKVINWVQRSIWENGDSLE
ELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSDDDHIQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLC
LAVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDH
WSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDV
FDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAIS

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>41761_41761_4_KDM3A-IVNS1ABP_KDM3A_chr2_86709225_ENST00000542128_IVNS1ABP_chr1_185276794_ENST00000367498_length(transcript)=5748nt_BP=2529nt
ATGGTGCTCACGCTCGGAGAAAGTTGGCCGGTATTGGTGGGGAGGAGGTTTCTCAGTCTGTCCGCAGCCGACGGCAGCGATGGCAGCCAC
GACAGCTGGGACGTGGAGCGCGTCGCCGAGTGGCCCTGGCTCTCCGGGACCATTCGAGCTGTTTCCCACACCGACGTTACCAAGAAGGAT
CTGAAGACGTACAAACCTCTGTTGGACAAAGCTGGTTTGGGATCCATAACTTCTGTTCGCTTTCTGGGAGATCAACAAAGAGTATTTCTT
TCTAAAGACCTTTTGAAGCCTATACAGGATGTAAACAGTCTTCGACTTTCTCTTACGGATAATCAGATTGTCAGTAAAGAATTTCAAGCT
TTGATTGTGAAGCATTTAGATGAAAGCCATCTTTTAAAAGGTGACAAAAACTTAGTTGGTTCAGAAGTAAAAATTTATAGCTTGGACCCA
TCTACTCAGTGGTTTTCAGCAACCGTTATAAATGGAAACCCAGCATCAAAAACTCTTCAAGTCAACTGTGAGGAGATTCCAGCACTGAAA
ATTGTTGATCCGTCACTGATTCATGTTGAAGTTGTACACGATAACCTTGTGACATGTGGTAATTCTGCAAGAATTGGAGCTGTAAAACGC
AAGTCTTCTGAGAATAATGGAACCCTGGTTTCCAAACAAGCAAAATCTTGCTCTGAGGCCTCTCCCAGTATGTGTCCTGTGCAGTCTGTA
CCTACAACAGTTTTTAAGGAGATACTGCTTGGCTGTACTGCGGCAACTCCACCTAGTAAGGACCCAAGACAGCAAAGTACTCCCCAGGCT
GCCAACTCTCCACCTAACCTTGGAGCAAAAATTCCTCAAGGATGTCATAAACAAAGTTTACCAGAGGAAATTTCTTCCTGTCTAAATACA
AAGTCTGAAGCTCTGAGAACAAAACCAGATGTCTGCAAAGCAGGGTTGCTCTCAAAGTCCTCTCAGATTGGAACTGGAGACTTGAAAATT
CTGACTGAGCCAAAAGGCAGCTGTACTCAGCCTAAGACAAACACTGATCAGGAAAACAGATTGGAGTCTGTTCCACAAGCATTGACTGGC
CTTCCTAAGGAGTGCTTACCTACAAAGGCTTCTTCTAAGGCAGAATTGGAAATTGCCAATCCTCCTGAACTGCAGAAGCACCTAGAACAT
GCACCTTCCCCATCGGATGTTTCAAATGCACCAGAAGTGAAAGCAGGTGTCAATAGTGATAGCCCTAATAACTGTTCAGGAAAAAAGGTA
GAACCTTCAGCTTTAGCTTGCCGATCACAGAATTTAAAGGAATCTTCAGTAAAAGTAGATAATGAAAGCTGTTGTTCAAGAAGCAACAAT
AAAATCCAGAATGCCCCATCCAGGAAGTCGGTTTTGACAGACCCAGCTAAACTCAAAAAGCTGCAACAGAGTGGCGAGGCCTTCGTACAG
GATGATTCTTGTGTGAACATCGTGGCACAGTTGCCTAAATGCCGAGAGTGTCGCTTGGACAGTCTCCGCAAGGATAAGGAGCAACAGAAG
GACTCACCTGTGTTTTGCCGCTTCTTTCACTTCAGGAGGTTACAATTCAACAAACATGGTGTGTTGCGGGTAGAAGGCTTCTTAACACCA
AACAAGTATGACAATGAAGCAATTGGCTTGTGGTTACCTTTAACCAAAAACGTTGTGGGGATTGATTTGGACACAGCAAAGTACATCTTG
GCCAACATTGGAGACCACTTCTGTCAAATGGTGATTTCTGAAAAGGAAGCTATGTCAACTATTGAGCCACACAGACAGGTTGCTTGGAAG
CGAGCTGTCAAAGGTGTTCGAGAAATGTGTGATGTGTGCGACACCACCATCTTCAACCTGCACTGGGTGTGTCCTCGGTGTGGGTTTGGA
GTATGTGTGGACTGCTACCGGATGAAGAGAAAGAATTGCCAACAGGGTGCTGCTTACAAGACTTTCTCTTGGCTAAAATGTGTGAAGAGT
CAGATACATGAACCAGAGAACTTAATGCCCACACAGATCATTCCTGGAAAAGCACTCTATGATGTTGGAGACATTGTTCATTCTGTAAGA
GCGAAATGGGGAATAAAGGCAAACTGCCCTTGTTCAAACAGGCAATTCAAACTCTTTTCAAAGCCAGCCTCAAAGGAAGACCTAAAACAG
ACTTCTTTAGCTGGAGAAAAACCGACTCTTGGTGCAGTGCTCCAGCAGAATCCCTCAGTGTTGGAGCCAGCAGCTGTGGGTGGGGAAGCA
GCCTCCAAGCCAGCCGGCAGCATGAAGCCTGCCTGTCCAGCCAGCACATCTCCTCTAAACTGGCTGGCCGACCTAACCAGCGGGAATGTC
AACAAGGAAAACAAGGAAAAACAACCAACAATGCCAATTTTAAAGAATGAAATCAAATGCCTTCCACCCCTCCCACCTTTAAGCAAATCC
AGCACAGTCCTCCATACGTTTAACAGCACAATTTTGACACCCGTAAGCAACAACAATTCTGGTTTCCTCCGGAATCTCTTGAATTCTTCT
ACAGGAAAGGTTTGTGGTGATTATTTACTGTCTAGAATGGATGTTACCAGCTGCATCTCTTACCGAAATTTTGCAAGTTGTATGGGAGAC
TCCCGTTTGTTGAATAAGGTTGATGCTTATATTCAGGAGCATTTGTTACAAATTTCTGAAGAGGAGGAGTTTCTTAAGCTTCCAAGGCTA
AAGTTGGAGGTAATGCTTGAAGATAATGTTTGCTTGCCCAGCAATGGCAAATTATATACAAAGGTAATCAACTGGGTGCAGCGTAGCATC
TGGGAGAATGGAGACAGTCTGGAAGAGCTGATGGAAGAGGTTCAAACCTTGTACTACTCAGCTGATCACAAGCTGCTTGATGGGAACCTA
CTAGATGGACAGGCTGAGGTGTTTGGCAGTGATGATGACCACATTCAGTTTGTGCAGAAAAAGCCACCACGTGAGAATGGCCATAAGCAG
ATAAGTAGCAGTTCAACTGGATGTCTCTCTTCTCCAAATGCTACAGTACAAAGCCCTAAGCATGAGTGGAAAATCGTTGCTTCAGAAAAG
ACTTCAAATAACACTTACTTGTGCCTGGCTGTGCTGGATGGTATATTCTGTGTCATTTTTCTTCATGGGAGAAACAGCCCACAGAGCTCA
CCAACAAGTACTCCAAAACTAAGTAAGAGTTTAAGCTTTGAGATGCAACAAGATGAGCTAATCGAAAAGCCCATGTCTCCTATGCAGTAC
GCACGATCTGGTCTGGGAACAGCAGAGATGAATGGCAAACTCATAGCTGCAGGTGGCTATAACAGAGAGGAATGTCTTCGAACAGTCGAA
TGCTATAATCCACATACAGATCACTGGTCCTTTCTTGCTCCCATGAGAACACCAAGAGCCCGATTTCAAATGGCTGTACTCATGGGCCAG
CTCTATGTGGTAGGTGGATCAAATGGCCACTCAGATGACCTGAGTTGTGGAGAGATGTATGATTCAAACATAGATGACTGGATTCCTGTT
CCAGAATTGAGAACTAACCGTTGTAATGCAGGAGTGTGTGCTCTGAATGGAAAGTTATACATCGTTGGTGGCTCTGATCCATATGGTCAA
AAAGGACTGAAAAATTGTGATGTATTTGATCCTGTAACAAAGTTGTGGACAAGCTGTGCCCCTCTTAACATTCGGAGACACCAGTCTGCA
GTCTGTGAGCTTGGTGGTTATTTGTACATAATCGGAGGTGCAGAATCTTGGAATTGTCTGAACACAGTAGAACGATACAATCCTGAAAAT
AATACCTGGACTTTAATTGCACCCATGAATGTGGCTAGGCGAGGAGCTGGAGTGGCTGTTCTTAATGGAAAACTGTTTGTATGTGGTGGC
TTTGATGGTTCTCATGCCATCAGTTGTGTGGAAATGTATGATCCAACTAGAAATGAATGGAAGATGATGGGAAATATGACTTCACCAAGG
AGCAATGCTGGGATTGCAACTGTAGGGAACACCATTTATGCAGTGGGAGGATTCGATGGCAATGAATTTCTGAATACGGTGGAAGTCTAT
AACCTTGAGTCAAATGAATGGAGCCCCTATACAAAGATTTTCCAGTTTTAACAAATTTAAGACCCTCTCAAACTAACAGGCTTAGTGATG
TAATTATGGTTAGTAGAGGTACACTTGTGAATAAAGAGGGTGGGTGGGTATAGATGTTGCTAACAGCAACACAAAGCTTTTGCATATTGC
ATACTATTAAACATGCTGTACATACTTTTTGGGTTTATTTGGAAAGGAATGCAAAGATGAAGGTCTGTTTTGTGTACTTTTAAGACTTTG
GTTATTTTACTTTTTGGAAAAGAATAAACCAAGAATTGATTGGGCACATCATTTCAAGAAGTCCCCTCTCCTCCACATTTGTTTTGCCAA
TTTGCACATTAAATGACTCTTCCCTCAAATGTGTACTATGGGGTAAAAGGGGTAGGGTTTAAAGATGTAGACAGTTGGGTTTTTTAAGGG
CCCTTTTTCAATAACTGGAACACTCTATAACAAAGGATACTTATTTAAATAGATGACATTGACTATTTTTGTTTTTATTAAAAGGAAGCT
TACATGCCTACCAATATTTAATCTTTTATGATTGCCTTTTTATAACTTTTTATATTCTCAGCAGAGTGCTTTACCAATTGAAGTAAAATG
TGGCAGGCTGGAGTTATTGAAGCAGAGTGGCAGTCTTCAGTTTGCAGAGTAGGGGTCTGTCTTTTAAACTCTGAGTGCAAACTTCAGAGT
TCTTGCCTTGGCTGCAGTTTTTTTCCTTCAAGAATGCAGTACTAACATTTATTTGAGTGGAGTTACTGAACAGTAACATAGCTGTGATTT
TTGGTATTTGAAACACTGGTTTTAAATATTTTGACTTGTTGAGGGTATGTTTTATATAGCAAGACATTATATAGCAGTAAAAAATGGTGT
TTTATCTTCTATATAATTCCTGTTTTTATTATTAACAAAACAGTCCTAAATAGCAGCCCTCAATTGTGAAAAAATTTACTTTAAACTACA
TTAGGTTGTGAATGCAGGTTTTATCAGAACTATGTTTTTGTTCAGTTTATCTGTTCATATGGATAAATATTGGTTGGGATGACTTGGTGT
CTAATGTGTAGTGCTACACACCTAACTTATGGGGCCAAAATAGCATGTCCTAATGCTTGCTGCTGATTTAAACACATTAAAGGTACTTTG
CAGGAAATCCTTGCACCATGGGATTAATATCCAATTGCTGCTTGTACACTCATTCATTACTAAAAGTTTTGAGAAATTTTTTTTTCCAGT
AATGAGCTTAAGAAATTTGTGGAAAATAACTCACCTGGCATCTTACATCTGAAATAAGGAATGATATAAGGTTTTTTTTTCTCACAGAAG
ATGAAGCACACAGGAACCTAATGGGCCAACTGGGATGAGGTGACTATTCTGAGATGACTATTCAGTGGCTAACTTGGGTTAGGAAGAAAA
TAATTAGGTATTTTCTCCAAATGTTCACTGGTACTCTGCCACTTTATTTCTCTCATCTGTTACACAAAGAACCACCAGGAAAGCAAATCA
GTTTGGTTGGTAACTCTGTAATTCCTAACTATCACTGGTTTGGTTCTGGACTAAAACTACATTGACAGATTGAATTTGCCTAATATGATG

>41761_41761_4_KDM3A-IVNS1ABP_KDM3A_chr2_86709225_ENST00000542128_IVNS1ABP_chr1_185276794_ENST00000367498_length(amino acids)=1366AA_BP=828
MVLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWLSGTIRAVSHTDVTKKDLKTYKPLLDKAGLGSITSVRFLGDQQRVFL
SKDLLKPIQDVNSLRLSLTDNQIVSKEFQALIVKHLDESHLLKGDKNLVGSEVKIYSLDPSTQWFSATVINGNPASKTLQVNCEEIPALK
IVDPSLIHVEVVHDNLVTCGNSARIGAVKRKSSENNGTLVSKQAKSCSEASPSMCPVQSVPTTVFKEILLGCTAATPPSKDPRQQSTPQA
ANSPPNLGAKIPQGCHKQSLPEEISSCLNTKSEALRTKPDVCKAGLLSKSSQIGTGDLKILTEPKGSCTQPKTNTDQENRLESVPQALTG
LPKECLPTKASSKAELEIANPPELQKHLEHAPSPSDVSNAPEVKAGVNSDSPNNCSGKKVEPSALACRSQNLKESSVKVDNESCCSRSNN
KIQNAPSRKSVLTDPAKLKKLQQSGEAFVQDDSCVNIVAQLPKCRECRLDSLRKDKEQQKDSPVFCRFFHFRRLQFNKHGVLRVEGFLTP
NKYDNEAIGLWLPLTKNVVGIDLDTAKYILANIGDHFCQMVISEKEAMSTIEPHRQVAWKRAVKGVREMCDVCDTTIFNLHWVCPRCGFG
VCVDCYRMKRKNCQQGAAYKTFSWLKCVKSQIHEPENLMPTQIIPGKALYDVGDIVHSVRAKWGIKANCPCSNRQFKLFSKPASKEDLKQ
TSLAGEKPTLGAVLQQNPSVLEPAAVGGEAASKPAGSMKPACPASTSPLNWLADLTSGNVNKENKEKQPTMPILKNEIKCLPPLPPLSKS
STVLHTFNSTILTPVSNNNSGFLRNLLNSSTGKVCGDYLLSRMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRL
KLEVMLEDNVCLPSNGKLYTKVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSDDDHIQFVQKKPPRENGHKQ
ISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCLAVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQY
ARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPV
PELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPEN
NTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVY

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Fusion Gene PPI Analysis for KDM3A-IVNS1ABP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KDM3A-IVNS1ABP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KDM3A-IVNS1ABP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human