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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:EIF2AK2-CEBPZ (FusionGDB2 ID:HG5610TG10153)

Fusion Gene Summary for EIF2AK2-CEBPZ

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF2AK2-CEBPZ
Fusion gene ID: hg5610tg10153
HgeneTgene
Gene symbol

EIF2AK2

CEBPZ

Gene ID

5610

10153

Gene nameeukaryotic translation initiation factor 2 alpha kinase 2CCAAT enhancer binding protein zeta
SynonymsEIF2AK1|PKR|PPP1R83|PRKRCBF|CBF2|HSP-CBF|NOC1
Cytomap('EIF2AK2')('CEBPZ')

2p22.2

2p22.2

Type of geneprotein-codingprotein-coding
Descriptioninterferon-induced, double-stranded RNA-activated protein kinaseP1/eIF-2A protein kinasedouble stranded RNA activated protein kinaseeIF-2A protein kinase 2interferon-inducible elF2alpha kinasep68 kinaseprotein kinase Rprotein kinase, interferon-indCCAAT/enhancer-binding protein zetaCCAAT-box-binding transcription factorCCAAT/enhancer binding protein (C/EBP), zetaCCAAT/enhancer binding protein cebp family zeta
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000233057, ENST00000395127, 
ENST00000405334, 
Fusion gene scores* DoF score6 X 8 X 4=1927 X 8 X 6=336
# samples 910
** MAII scorelog2(9/192*10)=-1.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/336*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EIF2AK2 [Title/Abstract] AND CEBPZ [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEIF2AK2(37349649)-CEBPZ(37429046), # samples:3
Anticipated loss of major functional domain due to fusion event.EIF2AK2-CEBPZ seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EIF2AK2-CEBPZ seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EIF2AK2-CEBPZ seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EIF2AK2-CEBPZ seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EIF2AK2-CEBPZ seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
EIF2AK2-CEBPZ seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
EIF2AK2-CEBPZ seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
EIF2AK2-CEBPZ seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
EIF2AK2-CEBPZ seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF2AK2

GO:0006468

protein phosphorylation

19189853

HgeneEIF2AK2

GO:0017148

negative regulation of translation

12882984

HgeneEIF2AK2

GO:0035455

response to interferon-alpha

19840259

HgeneEIF2AK2

GO:0046777

protein autophosphorylation

22801494

HgeneEIF2AK2

GO:0051092

positive regulation of NF-kappaB transcription factor activity

15121867

TgeneCEBPZ

GO:0045944

positive regulation of transcription by RNA polymerase II

2247079


check buttonFusion gene breakpoints across EIF2AK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CEBPZ (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-FD-A3NA-01AEIF2AK2chr2

37362627

-CEBPZchr2

37429046

-
ChimerDB4BLCATCGA-FD-A3NA-01AEIF2AK2chr2

37362627

-CEBPZchr2

37430151

-
ChimerDB4BRCATCGA-A2-A04P-01AEIF2AK2chr2

37349648

-CEBPZchr2

37429045

-
ChimerDB4BRCATCGA-A2-A04P-01AEIF2AK2chr2

37349649

-CEBPZchr2

37429046

-
ChimerDB4BRCATCGA-A2-A04PEIF2AK2chr2

37349648

-CEBPZchr2

37429046

-
ChimerDB4BRCATCGA-E2-A1AZ-01AEIF2AK2chr2

37347102

-CEBPZchr2

37444180

-


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Fusion Gene ORF analysis for EIF2AK2-CEBPZ

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000233057ENST00000234170EIF2AK2chr2

37362627

-CEBPZchr2

37429046

-
Frame-shiftENST00000233057ENST00000234170EIF2AK2chr2

37362627

-CEBPZchr2

37430151

-
Frame-shiftENST00000233057ENST00000234170EIF2AK2chr2

37349648

-CEBPZchr2

37429045

-
Frame-shiftENST00000233057ENST00000234170EIF2AK2chr2

37349649

-CEBPZchr2

37429046

-
Frame-shiftENST00000233057ENST00000234170EIF2AK2chr2

37349648

-CEBPZchr2

37429046

-
Frame-shiftENST00000233057ENST00000234170EIF2AK2chr2

37347102

-CEBPZchr2

37444180

-
Frame-shiftENST00000395127ENST00000234170EIF2AK2chr2

37362627

-CEBPZchr2

37429046

-
Frame-shiftENST00000395127ENST00000234170EIF2AK2chr2

37362627

-CEBPZchr2

37430151

-
Frame-shiftENST00000395127ENST00000234170EIF2AK2chr2

37349648

-CEBPZchr2

37429045

-
Frame-shiftENST00000395127ENST00000234170EIF2AK2chr2

37349649

-CEBPZchr2

37429046

-
Frame-shiftENST00000395127ENST00000234170EIF2AK2chr2

37349648

-CEBPZchr2

37429046

-
Frame-shiftENST00000395127ENST00000234170EIF2AK2chr2

37347102

-CEBPZchr2

37444180

-
Frame-shiftENST00000405334ENST00000234170EIF2AK2chr2

37362627

-CEBPZchr2

37430151

-
In-frameENST00000405334ENST00000234170EIF2AK2chr2

37362627

-CEBPZchr2

37429046

-
In-frameENST00000405334ENST00000234170EIF2AK2chr2

37349648

-CEBPZchr2

37429045

-
In-frameENST00000405334ENST00000234170EIF2AK2chr2

37349649

-CEBPZchr2

37429046

-
In-frameENST00000405334ENST00000234170EIF2AK2chr2

37349648

-CEBPZchr2

37429046

-
In-frameENST00000405334ENST00000234170EIF2AK2chr2

37347102

-CEBPZchr2

37444180

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for EIF2AK2-CEBPZ


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for EIF2AK2-CEBPZ


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:37349649/chr2:37429046)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEIF2AK2chr2:37347102chr2:37444180ENST00000233057-1317100_167416552.0DomainDRBM 2
HgeneEIF2AK2chr2:37347102chr2:37444180ENST00000233057-13179_77416552.0DomainDRBM 1
HgeneEIF2AK2chr2:37347102chr2:37444180ENST00000395127-1317100_167416552.0DomainDRBM 2
HgeneEIF2AK2chr2:37347102chr2:37444180ENST00000395127-13179_77416552.0DomainDRBM 1
HgeneEIF2AK2chr2:37347102chr2:37444180ENST00000405334-1014100_167375511.0DomainDRBM 2
HgeneEIF2AK2chr2:37347102chr2:37444180ENST00000405334-10149_77375511.0DomainDRBM 1
HgeneEIF2AK2chr2:37349648chr2:37429045ENST00000233057-1217100_167355552.0DomainDRBM 2
HgeneEIF2AK2chr2:37349648chr2:37429045ENST00000233057-12179_77355552.0DomainDRBM 1
HgeneEIF2AK2chr2:37349648chr2:37429045ENST00000395127-1217100_167355552.0DomainDRBM 2
HgeneEIF2AK2chr2:37349648chr2:37429045ENST00000395127-12179_77355552.0DomainDRBM 1
HgeneEIF2AK2chr2:37349648chr2:37429045ENST00000405334-914100_167314511.0DomainDRBM 2
HgeneEIF2AK2chr2:37349648chr2:37429045ENST00000405334-9149_77314511.0DomainDRBM 1
HgeneEIF2AK2chr2:37349648chr2:37429046ENST00000233057-1217100_167355552.0DomainDRBM 2
HgeneEIF2AK2chr2:37349648chr2:37429046ENST00000233057-12179_77355552.0DomainDRBM 1
HgeneEIF2AK2chr2:37349648chr2:37429046ENST00000395127-1217100_167355552.0DomainDRBM 2
HgeneEIF2AK2chr2:37349648chr2:37429046ENST00000395127-12179_77355552.0DomainDRBM 1
HgeneEIF2AK2chr2:37349648chr2:37429046ENST00000405334-914100_167314511.0DomainDRBM 2
HgeneEIF2AK2chr2:37349648chr2:37429046ENST00000405334-9149_77314511.0DomainDRBM 1
HgeneEIF2AK2chr2:37349649chr2:37429046ENST00000233057-1217100_167355552.0DomainDRBM 2
HgeneEIF2AK2chr2:37349649chr2:37429046ENST00000233057-12179_77355552.0DomainDRBM 1
HgeneEIF2AK2chr2:37349649chr2:37429046ENST00000395127-1217100_167355552.0DomainDRBM 2
HgeneEIF2AK2chr2:37349649chr2:37429046ENST00000395127-12179_77355552.0DomainDRBM 1
HgeneEIF2AK2chr2:37349649chr2:37429046ENST00000405334-914100_167314511.0DomainDRBM 2
HgeneEIF2AK2chr2:37349649chr2:37429046ENST00000405334-9149_77314511.0DomainDRBM 1
HgeneEIF2AK2chr2:37362627chr2:37429046ENST00000233057-1017100_167261552.0DomainDRBM 2
HgeneEIF2AK2chr2:37362627chr2:37429046ENST00000233057-10179_77261552.0DomainDRBM 1
HgeneEIF2AK2chr2:37362627chr2:37429046ENST00000395127-1017100_167261552.0DomainDRBM 2
HgeneEIF2AK2chr2:37362627chr2:37429046ENST00000395127-10179_77261552.0DomainDRBM 1
HgeneEIF2AK2chr2:37362627chr2:37429046ENST00000405334-814100_167261511.0DomainDRBM 2
HgeneEIF2AK2chr2:37362627chr2:37429046ENST00000405334-8149_77261511.0DomainDRBM 1
HgeneEIF2AK2chr2:37347102chr2:37444180ENST00000233057-1317273_281416552.0Nucleotide bindingATP
HgeneEIF2AK2chr2:37347102chr2:37444180ENST00000395127-1317273_281416552.0Nucleotide bindingATP
HgeneEIF2AK2chr2:37347102chr2:37444180ENST00000405334-1014273_281375511.0Nucleotide bindingATP
HgeneEIF2AK2chr2:37349648chr2:37429045ENST00000233057-1217273_281355552.0Nucleotide bindingATP
HgeneEIF2AK2chr2:37349648chr2:37429045ENST00000395127-1217273_281355552.0Nucleotide bindingATP
HgeneEIF2AK2chr2:37349648chr2:37429045ENST00000405334-914273_281314511.0Nucleotide bindingATP
HgeneEIF2AK2chr2:37349648chr2:37429046ENST00000233057-1217273_281355552.0Nucleotide bindingATP
HgeneEIF2AK2chr2:37349648chr2:37429046ENST00000395127-1217273_281355552.0Nucleotide bindingATP
HgeneEIF2AK2chr2:37349648chr2:37429046ENST00000405334-914273_281314511.0Nucleotide bindingATP
HgeneEIF2AK2chr2:37349649chr2:37429046ENST00000233057-1217273_281355552.0Nucleotide bindingATP
HgeneEIF2AK2chr2:37349649chr2:37429046ENST00000395127-1217273_281355552.0Nucleotide bindingATP
HgeneEIF2AK2chr2:37349649chr2:37429046ENST00000405334-914273_281314511.0Nucleotide bindingATP
HgeneEIF2AK2chr2:37347102chr2:37444180ENST00000233057-1317331_357416552.0RegionNote=2 X 13 AA approximate repeats
HgeneEIF2AK2chr2:37347102chr2:37444180ENST00000395127-1317331_357416552.0RegionNote=2 X 13 AA approximate repeats
HgeneEIF2AK2chr2:37347102chr2:37444180ENST00000405334-1014331_357375511.0RegionNote=2 X 13 AA approximate repeats
HgeneEIF2AK2chr2:37349648chr2:37429045ENST00000233057-1217331_357355552.0RegionNote=2 X 13 AA approximate repeats
HgeneEIF2AK2chr2:37349648chr2:37429045ENST00000395127-1217331_357355552.0RegionNote=2 X 13 AA approximate repeats
HgeneEIF2AK2chr2:37349648chr2:37429046ENST00000233057-1217331_357355552.0RegionNote=2 X 13 AA approximate repeats
HgeneEIF2AK2chr2:37349648chr2:37429046ENST00000395127-1217331_357355552.0RegionNote=2 X 13 AA approximate repeats
HgeneEIF2AK2chr2:37349649chr2:37429046ENST00000233057-1217331_357355552.0RegionNote=2 X 13 AA approximate repeats
HgeneEIF2AK2chr2:37349649chr2:37429046ENST00000395127-1217331_357355552.0RegionNote=2 X 13 AA approximate repeats
HgeneEIF2AK2chr2:37347102chr2:37444180ENST00000233057-1317331_343416552.0RepeatNote=1
HgeneEIF2AK2chr2:37347102chr2:37444180ENST00000233057-1317345_357416552.0RepeatNote=2
HgeneEIF2AK2chr2:37347102chr2:37444180ENST00000395127-1317331_343416552.0RepeatNote=1
HgeneEIF2AK2chr2:37347102chr2:37444180ENST00000395127-1317345_357416552.0RepeatNote=2
HgeneEIF2AK2chr2:37347102chr2:37444180ENST00000405334-1014331_343375511.0RepeatNote=1
HgeneEIF2AK2chr2:37347102chr2:37444180ENST00000405334-1014345_357375511.0RepeatNote=2
HgeneEIF2AK2chr2:37349648chr2:37429045ENST00000233057-1217331_343355552.0RepeatNote=1
HgeneEIF2AK2chr2:37349648chr2:37429045ENST00000233057-1217345_357355552.0RepeatNote=2
HgeneEIF2AK2chr2:37349648chr2:37429045ENST00000395127-1217331_343355552.0RepeatNote=1
HgeneEIF2AK2chr2:37349648chr2:37429045ENST00000395127-1217345_357355552.0RepeatNote=2
HgeneEIF2AK2chr2:37349648chr2:37429046ENST00000233057-1217331_343355552.0RepeatNote=1
HgeneEIF2AK2chr2:37349648chr2:37429046ENST00000233057-1217345_357355552.0RepeatNote=2
HgeneEIF2AK2chr2:37349648chr2:37429046ENST00000395127-1217331_343355552.0RepeatNote=1
HgeneEIF2AK2chr2:37349648chr2:37429046ENST00000395127-1217345_357355552.0RepeatNote=2
HgeneEIF2AK2chr2:37349649chr2:37429046ENST00000233057-1217331_343355552.0RepeatNote=1
HgeneEIF2AK2chr2:37349649chr2:37429046ENST00000233057-1217345_357355552.0RepeatNote=2
HgeneEIF2AK2chr2:37349649chr2:37429046ENST00000395127-1217331_343355552.0RepeatNote=1
HgeneEIF2AK2chr2:37349649chr2:37429046ENST00000395127-1217345_357355552.0RepeatNote=2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEIF2AK2chr2:37347102chr2:37444180ENST00000233057-1317267_538416552.0DomainProtein kinase
HgeneEIF2AK2chr2:37347102chr2:37444180ENST00000395127-1317267_538416552.0DomainProtein kinase
HgeneEIF2AK2chr2:37347102chr2:37444180ENST00000405334-1014267_538375511.0DomainProtein kinase
HgeneEIF2AK2chr2:37349648chr2:37429045ENST00000233057-1217267_538355552.0DomainProtein kinase
HgeneEIF2AK2chr2:37349648chr2:37429045ENST00000395127-1217267_538355552.0DomainProtein kinase
HgeneEIF2AK2chr2:37349648chr2:37429045ENST00000405334-914267_538314511.0DomainProtein kinase
HgeneEIF2AK2chr2:37349648chr2:37429046ENST00000233057-1217267_538355552.0DomainProtein kinase
HgeneEIF2AK2chr2:37349648chr2:37429046ENST00000395127-1217267_538355552.0DomainProtein kinase
HgeneEIF2AK2chr2:37349648chr2:37429046ENST00000405334-914267_538314511.0DomainProtein kinase
HgeneEIF2AK2chr2:37349649chr2:37429046ENST00000233057-1217267_538355552.0DomainProtein kinase
HgeneEIF2AK2chr2:37349649chr2:37429046ENST00000395127-1217267_538355552.0DomainProtein kinase
HgeneEIF2AK2chr2:37349649chr2:37429046ENST00000405334-914267_538314511.0DomainProtein kinase
HgeneEIF2AK2chr2:37362627chr2:37429046ENST00000233057-1017267_538261552.0DomainProtein kinase
HgeneEIF2AK2chr2:37362627chr2:37429046ENST00000395127-1017267_538261552.0DomainProtein kinase
HgeneEIF2AK2chr2:37362627chr2:37429046ENST00000405334-814267_538261511.0DomainProtein kinase
HgeneEIF2AK2chr2:37362627chr2:37429046ENST00000233057-1017273_281261552.0Nucleotide bindingATP
HgeneEIF2AK2chr2:37362627chr2:37429046ENST00000395127-1017273_281261552.0Nucleotide bindingATP
HgeneEIF2AK2chr2:37362627chr2:37429046ENST00000405334-814273_281261511.0Nucleotide bindingATP
HgeneEIF2AK2chr2:37349648chr2:37429045ENST00000405334-914331_357314511.0RegionNote=2 X 13 AA approximate repeats
HgeneEIF2AK2chr2:37349648chr2:37429046ENST00000405334-914331_357314511.0RegionNote=2 X 13 AA approximate repeats
HgeneEIF2AK2chr2:37349649chr2:37429046ENST00000405334-914331_357314511.0RegionNote=2 X 13 AA approximate repeats
HgeneEIF2AK2chr2:37362627chr2:37429046ENST00000233057-1017331_357261552.0RegionNote=2 X 13 AA approximate repeats
HgeneEIF2AK2chr2:37362627chr2:37429046ENST00000395127-1017331_357261552.0RegionNote=2 X 13 AA approximate repeats
HgeneEIF2AK2chr2:37362627chr2:37429046ENST00000405334-814331_357261511.0RegionNote=2 X 13 AA approximate repeats
HgeneEIF2AK2chr2:37349648chr2:37429045ENST00000405334-914331_343314511.0RepeatNote=1
HgeneEIF2AK2chr2:37349648chr2:37429045ENST00000405334-914345_357314511.0RepeatNote=2
HgeneEIF2AK2chr2:37349648chr2:37429046ENST00000405334-914331_343314511.0RepeatNote=1
HgeneEIF2AK2chr2:37349648chr2:37429046ENST00000405334-914345_357314511.0RepeatNote=2
HgeneEIF2AK2chr2:37349649chr2:37429046ENST00000405334-914331_343314511.0RepeatNote=1
HgeneEIF2AK2chr2:37349649chr2:37429046ENST00000405334-914345_357314511.0RepeatNote=2
HgeneEIF2AK2chr2:37362627chr2:37429046ENST00000233057-1017331_343261552.0RepeatNote=1
HgeneEIF2AK2chr2:37362627chr2:37429046ENST00000233057-1017345_357261552.0RepeatNote=2
HgeneEIF2AK2chr2:37362627chr2:37429046ENST00000395127-1017331_343261552.0RepeatNote=1
HgeneEIF2AK2chr2:37362627chr2:37429046ENST00000395127-1017345_357261552.0RepeatNote=2
HgeneEIF2AK2chr2:37362627chr2:37429046ENST00000405334-814331_343261511.0RepeatNote=1
HgeneEIF2AK2chr2:37362627chr2:37429046ENST00000405334-814345_357261511.0RepeatNote=2


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Fusion Gene Sequence for EIF2AK2-CEBPZ


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for EIF2AK2-CEBPZ


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneEIF2AK2chr2:37347102chr2:37444180ENST00000233057-1317266_551416.0552.0TRAF5
HgeneEIF2AK2chr2:37347102chr2:37444180ENST00000395127-1317266_551416.0552.0TRAF5
HgeneEIF2AK2chr2:37347102chr2:37444180ENST00000405334-1014266_551375.0511.0TRAF5
HgeneEIF2AK2chr2:37349648chr2:37429045ENST00000233057-1217266_551355.6666666666667552.0TRAF5
HgeneEIF2AK2chr2:37349648chr2:37429045ENST00000395127-1217266_551355.6666666666667552.0TRAF5
HgeneEIF2AK2chr2:37349648chr2:37429045ENST00000405334-914266_551314.6666666666667511.0TRAF5
HgeneEIF2AK2chr2:37349648chr2:37429046ENST00000233057-1217266_551355.6666666666667552.0TRAF5
HgeneEIF2AK2chr2:37349648chr2:37429046ENST00000395127-1217266_551355.6666666666667552.0TRAF5
HgeneEIF2AK2chr2:37349648chr2:37429046ENST00000405334-914266_551314.6666666666667511.0TRAF5
HgeneEIF2AK2chr2:37349649chr2:37429046ENST00000233057-1217266_551355.6666666666667552.0TRAF5
HgeneEIF2AK2chr2:37349649chr2:37429046ENST00000395127-1217266_551355.6666666666667552.0TRAF5
HgeneEIF2AK2chr2:37349649chr2:37429046ENST00000405334-914266_551314.6666666666667511.0TRAF5
HgeneEIF2AK2chr2:37362627chr2:37429046ENST00000233057-1017266_551261.6666666666667552.0TRAF5
HgeneEIF2AK2chr2:37362627chr2:37429046ENST00000395127-1017266_551261.6666666666667552.0TRAF5
HgeneEIF2AK2chr2:37362627chr2:37429046ENST00000405334-814266_551261.6666666666667511.0TRAF5


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EIF2AK2-CEBPZ


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EIF2AK2-CEBPZ


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEIF2AK2C0021400Influenza1CTD_human
HgeneEIF2AK2C0033578Prostatic Neoplasms1CTD_human
HgeneEIF2AK2C0038220Status Epilepticus1CTD_human
HgeneEIF2AK2C0270823Petit mal status1CTD_human
HgeneEIF2AK2C0311335Grand Mal Status Epilepticus1CTD_human
HgeneEIF2AK2C0376358Malignant neoplasm of prostate1CTD_human
HgeneEIF2AK2C0393734Complex Partial Status Epilepticus1CTD_human
HgeneEIF2AK2C0751522Status Epilepticus, Subclinical1CTD_human
HgeneEIF2AK2C0751523Non-Convulsive Status Epilepticus1CTD_human
HgeneEIF2AK2C0751524Simple Partial Status Epilepticus1CTD_human