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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:EIF2AK2-STRN (FusionGDB2 ID:HG5610TG6801)

Fusion Gene Summary for EIF2AK2-STRN

Fusion gene summary

Fusion gene information	Fusion gene name: EIF2AK2-STRN
	Fusion gene ID: hg5610tg6801
		Hgene	Tgene
	Gene symbol	EIF2AK2	STRN
	Gene ID	5610	6801
	Gene name	eukaryotic translation initiation factor 2 alpha kinase 2	striatin
	Synonyms	EIF2AK1\|PKR\|PPP1R83\|PRKR	PPP2R6A\|SG2NA\|STRN1
	Cytomap	('EIF2AK2')('STRN') 2p22.2	2p22.2
	Type of gene	protein-coding	protein-coding
	Description	interferon-induced, double-stranded RNA-activated protein kinaseP1/eIF-2A protein kinasedouble stranded RNA activated protein kinaseeIF-2A protein kinase 2interferon-inducible elF2alpha kinasep68 kinaseprotein kinase Rprotein kinase, interferon-ind	striatinprotein phosphatase 2 regulatory subunit B'''alphastriatin, calmodulin binding protein
	Modification date	20200313	20200313
	UniProtAcc	.	O43815
	Ensembl transtripts involved in fusion gene	ENST00000233057, ENST00000395127, ENST00000405334,
Fusion gene scores	* DoF score	6 X 8 X 4=192	3 X 2 X 1=6
	# samples	9	4
	** MAII score	log2(9/192*10)=-1.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/6*10)=2.73696559416621
Context	PubMed: EIF2AK2 [Title/Abstract] AND STRN [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	EIF2AK2(37341874)-STRN(37152351), # samples:2
Anticipated loss of major functional domain due to fusion event.	EIF2AK2-STRN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EIF2AK2-STRN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EIF2AK2-STRN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EIF2AK2-STRN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EIF2AK2-STRN seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. EIF2AK2-STRN seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. EIF2AK2-STRN seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. EIF2AK2-STRN seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. EIF2AK2-STRN seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EIF2AK2	GO:0006468	protein phosphorylation	19189853
Hgene	EIF2AK2	GO:0017148	negative regulation of translation	12882984
Hgene	EIF2AK2	GO:0035455	response to interferon-alpha	19840259
Hgene	EIF2AK2	GO:0046777	protein autophosphorylation	22801494
Hgene	EIF2AK2	GO:0051092	positive regulation of NF-kappaB transcription factor activity	15121867

Fusion gene breakpoints across EIF2AK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across STRN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-OL-A5D8-01A	EIF2AK2	chr2	37341874	-	STRN	chr2	37152351	-

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Fusion Gene ORF analysis for EIF2AK2-STRN

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000233057	ENST00000263918	EIF2AK2	chr2	37341874	-	STRN	chr2	37152351	-
Frame-shift	ENST00000233057	ENST00000379213	EIF2AK2	chr2	37341874	-	STRN	chr2	37152351	-
Frame-shift	ENST00000395127	ENST00000263918	EIF2AK2	chr2	37341874	-	STRN	chr2	37152351	-
Frame-shift	ENST00000395127	ENST00000379213	EIF2AK2	chr2	37341874	-	STRN	chr2	37152351	-
In-frame	ENST00000405334	ENST00000263918	EIF2AK2	chr2	37341874	-	STRN	chr2	37152351	-
In-frame	ENST00000405334	ENST00000379213	EIF2AK2	chr2	37341874	-	STRN	chr2	37152351	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000405334	EIF2AK2	chr2	37341874	-	ENST00000263918	STRN	chr2	37152351	-	9179	1254	0	3362	1120
ENST00000405334	EIF2AK2	chr2	37341874	-	ENST00000379213	STRN	chr2	37152351	-	4379	1254	0	3251	1083

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000405334	ENST00000263918	EIF2AK2	chr2	37341874	-	STRN	chr2	37152351	-	7.29E-05	0.99992716
ENST00000405334	ENST00000379213	EIF2AK2	chr2	37341874	-	STRN	chr2	37152351	-	0.000312269	0.9996878

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Fusion Genomic Features for EIF2AK2-STRN

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for EIF2AK2-STRN

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:37341874/chr2:37152351)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	STRN O43815
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EIF2AK2

chr2:37341874

chr2:37152351

ENST00000233057

100_167

459

552.0

Domain

DRBM 2

Hgene

EIF2AK2

chr2:37341874

chr2:37152351

ENST00000233057

9_77

459

552.0

Domain

DRBM 1

Hgene

EIF2AK2

chr2:37341874

chr2:37152351

ENST00000395127

100_167

459

552.0

Domain

DRBM 2

Hgene

EIF2AK2

chr2:37341874

chr2:37152351

ENST00000395127

9_77

459

552.0

Domain

DRBM 1

Hgene

EIF2AK2

chr2:37341874

chr2:37152351

ENST00000405334

100_167

418

511.0

Domain

DRBM 2

Hgene

EIF2AK2

chr2:37341874

chr2:37152351

ENST00000405334

9_77

418

511.0

Domain

DRBM 1

Hgene

EIF2AK2

chr2:37341874

chr2:37152351

ENST00000233057

273_281

459

552.0

Nucleotide binding

ATP

Hgene

EIF2AK2

chr2:37341874

chr2:37152351

ENST00000395127

273_281

459

552.0

Nucleotide binding

ATP

Hgene

EIF2AK2

chr2:37341874

chr2:37152351

ENST00000405334

273_281

418

511.0

Nucleotide binding

ATP

Hgene

EIF2AK2

chr2:37341874

chr2:37152351

ENST00000233057

331_357

459

552.0

Region

Note=2 X 13 AA approximate repeats

Hgene

EIF2AK2

chr2:37341874

chr2:37152351

ENST00000395127

331_357

459

552.0

Region

Note=2 X 13 AA approximate repeats

Hgene

EIF2AK2

chr2:37341874

chr2:37152351

ENST00000405334

331_357

418

511.0

Region

Note=2 X 13 AA approximate repeats

Hgene

EIF2AK2

chr2:37341874

chr2:37152351

ENST00000233057

331_343

459

552.0

Repeat

Note=1

Hgene

EIF2AK2

chr2:37341874

chr2:37152351

ENST00000233057

345_357

459

552.0

Repeat

Note=2

Hgene

EIF2AK2

chr2:37341874

chr2:37152351

ENST00000395127

331_343

459

552.0

Repeat

Note=1

Hgene

EIF2AK2

chr2:37341874

chr2:37152351

ENST00000395127

345_357

459

552.0

Repeat

Note=2

Hgene

EIF2AK2

chr2:37341874

chr2:37152351

ENST00000405334

331_343

418

511.0

Repeat

Note=1

Hgene

EIF2AK2

chr2:37341874

chr2:37152351

ENST00000405334

345_357

418

511.0

Repeat

Note=2

Tgene

STRN

chr2:37341874

chr2:37152351

ENST00000263918

149_166

781.0

Region

Calmodulin-binding

Tgene

STRN

chr2:37341874

chr2:37152351

ENST00000379213

149_166

732.0

Region

Calmodulin-binding

Tgene

STRN

chr2:37341874

chr2:37152351

ENST00000263918

461_500

781.0

Repeat

Note=WD 1

Tgene

STRN

chr2:37341874

chr2:37152351

ENST00000263918

514_553

781.0

Repeat

Note=WD 2

Tgene

STRN

chr2:37341874

chr2:37152351

ENST00000263918

567_606

781.0

Repeat

Note=WD 3

Tgene

STRN

chr2:37341874

chr2:37152351

ENST00000263918

662_701

781.0

Repeat

Note=WD 4

Tgene

STRN

chr2:37341874

chr2:37152351

ENST00000263918

704_743

781.0

Repeat

Note=WD 5

Tgene

STRN

chr2:37341874

chr2:37152351

ENST00000263918

750_779

781.0

Repeat

Note=WD 6

Tgene

STRN

chr2:37341874

chr2:37152351

ENST00000379213

461_500

732.0

Repeat

Note=WD 1

Tgene

STRN

chr2:37341874

chr2:37152351

ENST00000379213

514_553

732.0

Repeat

Note=WD 2

Tgene

STRN

chr2:37341874

chr2:37152351

ENST00000379213

567_606

732.0

Repeat

Note=WD 3

Tgene

STRN

chr2:37341874

chr2:37152351

ENST00000379213

662_701

732.0

Repeat

Note=WD 4

Tgene

STRN

chr2:37341874

chr2:37152351

ENST00000379213

704_743

732.0

Repeat

Note=WD 5

Tgene

STRN

chr2:37341874

chr2:37152351

ENST00000379213

750_779

732.0

Repeat

Note=WD 6

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EIF2AK2

chr2:37341874

chr2:37152351

ENST00000233057

267_538

459

552.0

Domain

Protein kinase

Hgene

EIF2AK2

chr2:37341874

chr2:37152351

ENST00000395127

267_538

459

552.0

Domain

Protein kinase

Hgene

EIF2AK2

chr2:37341874

chr2:37152351

ENST00000405334

267_538

418

511.0

Domain

Protein kinase

Tgene

STRN

chr2:37341874

chr2:37152351

ENST00000263918

53_120

781.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

STRN

chr2:37341874

chr2:37152351

ENST00000379213

53_120

732.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

STRN

chr2:37341874

chr2:37152351

ENST00000263918

55_63

781.0

Region

Caveolin-binding

Tgene

STRN

chr2:37341874

chr2:37152351

ENST00000379213

55_63

732.0

Region

Caveolin-binding

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Fusion Gene Sequence for EIF2AK2-STRN

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>25665_25665_1_EIF2AK2-STRN_EIF2AK2_chr2_37341874_ENST00000405334_STRN_chr2_37152351_ENST00000263918_length(transcript)=9179nt_BP=1254nt
ATGGCTGGTGATCTTTCAGCAGGTTTCTTCATGGAGGAACTTAATACATACCGTCAGAAGCAGGGAGTAGTACTTAAATATCAAGAACTG
CCTAATTCAGGACCTCCACATGATAGGAGGTTTACATTTCAAGTTATAATAGATGGAAGAGAATTTCCAGAAGGTGAAGGTAGATCAAAG
AAGGAAGCAAAAAATGCCGCAGCCAAATTAGCTGTTGAGATACTTAATAAGGAAAAGAAGGCAGTTAGTCCTTTATTATTGACAACAACG
AATTCTTCAGAAGGATTATCCATGGGGAATTACATAGGCCTTATCAATAGAATTGCCCAGAAGAAAAGACTAACTGTAAATTATGAACAG
TGTGCATCGGGGGTGCATGGGCCAGAAGGATTTCATTATAAATGCAAAATGGGACAGAAAGAATATAGTATTGGTACAGGTTCTACTAAA
CAGGAAGCAAAACAATTGGCCGCTAAACTTGCATATCTTCAGATATTATCAGAAGAAACCTCAGTGAAATCTGACTACCTGTCCTCTGGT
TCTTTTGCTACTACGTGTGAGTCCCAAAGCAACTCTTTAGTGACCAGCACACTCGCTTCTGAATCATCATCTGAAGGTGACTTCTCAGCA
GATACATCAGAGATAAATTCTAACAGTGACAGTTTAAACAGTTCTTCGTTGCTTATGAATGGTCTCAGAAATAATCAAAGGAAGGCAAAA
AGATCTTTGGCACCCAGATTTGACCTTCCTGACATGAAAGAAACAAAGTATACTGTGGACAAGAGGAAGGCGGAGCGTGAAGTAAAAGCA
TTGGCAAAACTTGATCATGTAAATATTGTTCACTACAATGGCTGTTGGGATGGATTTGATTATGATCCTGAGACCAGTGATGATTCTCTT
GAGAGCAGTGATTATGATCCTGAGAACAGCAAAAATAGTTCAAGGTCAAAGACTAAGTGCCTTTTCATCCAAATGGAATTCTGTGATAAA
GGGACCTTGGAACAATGGATTGAAAAAAGAAGAGGCGAGAAACTAGACAAAGTTTTGGCTTTGGAACTCTTTGAACAAATAACAAAAGGG
GTGGATTATATACATTCAAAAAAATTAATTCATAGAGATCTTAAGCCAAGTAATATATTCTTAGTAGATACAAAACAAGTAAAGATTGGA
GACTTTGGACTTGTAACATCTCTGAAAAATGATGGAAAGCGAACAAGGAGTAAGGGAACTTTGCGATACATGAGCCCAGAACAGGCCCAG
ATTGCCTTCCTGCAGGGAGAAAGGAAGGGCCAAGAAAATTTGAAGAAGGATCTTGTGAGGAGGATCAAAATGTTGGAGTATGCTCTTAAA
CAGGAAAGAGCCAAATACCACAAGTTGAAATACGGGACAGAATTGAATCAGGGAGATATGAAGCCTCCAAGCTATGATTCTGATGAAGGT
AATGAAACAGAAGTGCAGCCACAACAAAACAGCCAGTTAATGTGGAAACAAGGTCGACAACTACTCAGACAGTATCTACAGGAGGTGGGT
TATACAGATACTATTCTAGATGTGAAATCTAAACGAGTGCGAGCTTTGTTGGGCTTTTCAAGTGATGTCACGGACAGGGAAGATGACAAA
AATCAGGACTCAGTTGTAAATGGCACAGAGGCTGAAGTTAAAGAGACAGCAATGATTGCAAAATCTGAGTTAACAGATTCTGCCTCCGTG
CTGGATAATTTCAAATTCCTTGAAAGTGCAGCTGCAGATTTCAGTGATGAAGATGAAGATGATGATGTTGATGGAAGAGAGAAAAGCGTC
ATTGATACTTCAACAATTGTTAGGAAAAAAGCATTGCCTGACAGCGGTGAAGATCGAGATACAAAAGAAGCTCTAAAGGAGTTTGACTTC
TTGGTTACATCAGAGGAAGGAGACAATGAATCTAGAAGTGCAGGCGATGGAACAGACTGGGAAAAGGAAGACCAGTGTCTCATGCCTGAA
GCCTGGAATGTGGACCAGGGAGTAATTACCAAACTCAAGGAACAATACAAAAAGGAGAGAAAGGGGAAAAAGGGGGTGAAGAGGCCCAAT
AGGTCAAAACTACAAGATATGCTTGCTAATTTGAGAGATGTTGATGAACTTCCTTCATTGCAGCCATCTGTGGGTTCACCTTCCAGACCC
AGCAGCTCCAGGCTTCCTGAACATGAAATTAATAGGGCAGATGAAGTGGAAGCATTGACATTTCCTCCTTCTTCTGGAAAGTCATTCATC
ATGGGAGCAGATGAAGCCCTTGAAAGTGAACTGGGACTTGGAGAACTAGCAGGCCTTACGGTGGCCAATGAAGCAGACTCACTAACTTAT
GATATAGCAAACAATAAAGATGCATTGAGGAAGACATGGAACCCTAAGTTTACATTGAGAAGTCACTTTGATGGCATCCGAGCCCTTGCT
TTCCATCCCATTGAGCCTGTTTTGATAACAGCATCAGAGGATCACACATTAAAAATGTGGAATTTACAGAAAACAGCCCCAGCCAAAAAG
AGCACTTCTCTTGATGTAGAACCTATCTATACATTCAGAGCCCATAAAGGTCCAGTGCTTTGTGTGGTAATGAGCAGCAATGGTGAGCAG
TGTTACAGTGGTGGTACTGATGGACTGATCCAGGGCTGGAATACCACTAATCCCAACATCGACCCCTATGATTCTTATGATCCTTCTGTT
TTACGAGGCCCTCTGCTAGGCCACACGGATGCAGTCTGGGGTTTGGCTTATAGTGCAGCACATCAGCGTTTGTTGTCCTGTTCAGCAGAT
GGCACTCTGCGTTTATGGAATACAACTGAGGTTGCTCCAGCACTAAGTGTATTTAATGATACTAAAGAACTGGGAATCCCTGCCTCTGTG
GATCTAGTGAGCAGTGACCCGAGCCATATGGTAGCATCATTCAGCAAGGGATATACAAGCATTTTTAACATGGAAACACAACAACGCATT
CTCACTTTAGAATCCAATGTAGATACAACAGCCAACTCTTCCTGCCAAATAAATAGAGTCATCAGTCATCCTACTCTTCCGATCAGCATC
ACTGCTCATGAAGACAGGCACATCAAATTCTATGATAACAATACAGGCAAACTGATCCACTCGATGGTAGCCCACCTAGAAGCTGTTACA
AGTTTAGCAGTTGATCCCAATGGCCTTTACTTGATGTCTGGCAGTCATGACTGTTCAATACGTTTATGGAATCTAGAAAGTAAGACGTGT
ATCCAAGAATTCACAGCTCATCGAAAAAAGTTTGAAGAATCGATTCATGATGTAGCTTTCCACCCATCCAAATGCTATATAGCCAGTGCT
GGAGCTGACGCACTGGCTAAAGTCTTTGTATGACGCAATGCATCATCTTCACCTTCTAGCTGTTTATAAGTAATCAACTGCACACAAGAG
ATACAGAAGACGAGGGCAAGAATCATCTCGTCCTGCCCTTTTGTTCTGCTGAAGGAGCACAGAGAACATTTGTTGAAGTATAGTTTTGCA
ATTCATATACTGTTTTCTAAAACTAAGGTTTGTTCAGGTTGCTGCAAGCTCAGCTGAATCTGTGAGCCTGAGGTCTGTTTCAAATTTCTC
CCCAATAGGCGCCTTTATTTCTGAGGTGGTTCTAATTCGCTAGGCAGGCCTGAGCGAATACAAGTTTAGCTTGTCCCTGTTGAGTAAGTA
GGGCATGCTACAATGGATAATTTAAAAGCTTGATAGCTGGGACTGAATAGAAGAAAACGGGAAACTTAGACCAAGTTCTCCCCTGAGAAA
TCTTGTTAAAACACATTAAGTAGTCAAAATAGTAATCTTTATCATATCTGCCATATTAACCCCTTTGTGTATAATGACCAGGCAGTGTTA
AACTGAGTTTTTAATTTGACTCTCCTTTCAGCTGTTCACATAAAGCACCTGGCAAAGCATTTTACCTGTTAGGGGGAGAAAAATGCAATA
ATATGTTAAATATATTATTATTCAGAAATGCTAGACAAATAGTTTGCAAGCAGATTTCTATATTGTATTACAGTTTTGAAAACAGATTTG
GTATCATTCTAAAGTTTAGCTATCAAGCACTCACCATTGTGAAGAATAGTTGATCGACTCTGCTTTTACTAACAGATTTAACTTATTCAG
GTTTGAAATTCTGTTTATTTTTAAGGGTAAACAGGGCATATCTCTTTAATAATTTCTATTTTAAAATTCACTTTATTCATGTGACATTTA
TAGTACCAGAGTGATTATTTCATACCAATGAAATCTTACTTTTCAGTGACTGAAAAGATAGAATTTATTTGCTAATAATCATTTATCAAC
ACCCACCTAATCATGCTTCAGATGATCTGTGCTCTTTCTTCTTTGTCACGTTCAAGTTATCTGACATCTACCAAGAACAGTTCATAATTA
TTAATAGCCCAAAGAGTATGGTTAACTTCACGCAGCTGCTTTTGCAGAAGCACTAATAAAAACAAATATTTTGTACCCTAGAAGTCCTCT
ATTAATCCCTGTAAGAATCTCCTGGAAACCTGGATGAAAGAGTTTAATGCCAAATATTGGCTAAAAAGTTCTGTCTTTCTCTCTCCCTAT
TCCTCCCCCATTGTTTAATTGAGATATACATGTTTTAATGGGCAGTGGATCAGTATTGTTTCTGGGGAAATCCACACCTTAAAAGGCCAG
GCTTCCCCAGCCCAACTTACCTGTGACCCACCTACATGTGTTCACCTTTTGGGATTCTGAAGACCCTGCTATCTAGACCTAGTCTCCTGT
CATAAAGACATTATTTCTATAGTGGTTTATGTCTCTCTTACTCTTTGTCCCAAATGACAGAGACCAATCTAGAAATTGGAAATAAATTAT
TAACGTCCAACTTTCCACCAAAAAACATATAAATAGGCTCTTAGATTTTAAAAATATTAAATCTATAGATATTTTAACCAATTAAAACAA
TTTCTACATATTCCATTCCCCACATTTTCCATCGTCATAACAATGATGCTTCTCATGATACGTACATCTACTCCTTGAAAAAGTATTCTG
GTGGTGGTGTGGCTAATGATTGACAAATATTTCTGTAAAATTTCTGCCTGTTTGCCTCTAGAATTCTGCATTATACAGGCAAATTTTCTT
TAAAGCTAGAGACTTGTGCTAAATTTGCCTGATTTTCATACAGATATGCTGTAGTAATACAGCTACCTTTTCATTTCATCTTTGTGCTTT
GGTTAACAAGCAGGCTCAAGAGACTGCTTTGTGTAATTAAATGAATTGACCTAAACATGAGCTGTCAGGTGAATACTTAATATTTCCATG
CAGATACAGAATTCCATATTGTGTTCAGTAAATTTCTTTTGGTTCTTCACAGTGAAGAAAGAATGTTTCTAACCTAACATTTGTAGAAGG
ATACTGGAAAATTCCTTCCAGGAAGGAAGGAAGGAAGATGCCATTACTTGGTGTATTTATGATGGATGACCACAAAGCTATTGTTCTACC
AGTTATTAATTACCTTCTAAGATCTTCAGTTACTGCTTTATTAATGTCACTGAAATTCTAAAAACCAGGACATTCTTCCCCCGTTCATTT
TATGCTTCATGGTTGAAATTTTTCTGTCAGTGAGTGGAAAATAACCATGAGATACATAGACTGTAGCGCAAATGGAACTGTTGAAAGTTC
CTTAGAAAGCCAGTGCTGTGGCATTGGAGACTACGGAGAGAGTCTTCTCTACCAGCACTGCATGATCTCAGCCTAGAAATGAGCCAAAGC
TGTCTTCCAACCAGAGTAGCATATACATGTGTCTGACTTTTCCCCTAGCCTGTTGAACATTCAATGAAAATTCACAGAATGAACAAATTC
AATGTTTAAACAGCCATTGAAATGCTTTCATAGTGCTTCATTTGTAAATATTTTGTTTGAAATGTATTGGAATAGTATGAAAATTAGCGG
GAGGTTTGGATCCCTGCCTTATTTTCATATGCTGTGGATACATCTCTGGGAGCTTGCAGCACCCTTCTCAAAACTCAACTGTCATATGGA
GCTCATTTGCTACTCAAACCATAGACAGATTATTTAACAAAAGTGATATAATGACCTTCAGTATTTTTCTATTGAACAAGTTTAACAACT
TTTGCCATTAAACAAATACTTAGTTATGCAAAATATTTCGCTTTTATAATCATTTTAGTTATGACTAAAACGGGGGAAATTGAGCTGCAT
CACTGATGATGAACTTTGTGAGAAATTTTTTTTTTAATCTGACTTTCATTCCTTCAGTATTCTTGCTATAAATTTCTTTTGGAGATAATG
ATGAAGATTTATTTGAAAATGTCTAAAATGTATGTATATTTTATAAATATATATTATATATATTGTAAGAATATATATAATATATAAACT
ATATATATATATATATATATATATATATATATATATATATAAACCATAGGTGCATTTTACTGTTTTGTATTTTCATTTTTGGAGGTAGTA
TACACAGCAGATAATGATGAGTATGATGAGTGTTGTGCTGTTTGCTTTTGCAGTATAATATATAGTTCTAAGTGTTTAAATTACTGTATA
TACAATATTCATTATAGGCTAGCATGCTTGTTTTAAAGACTGTCATTCTAGTGTATTAAAATCTGAATGTAAGAAAACCTGGCTATTCAA
ATGTGAATTGAAAAATATTTTATTCTCAGTACTGAACTATTTCCATTGAACATTCAGACTTTTTAACAAAAACAAATATCATCAAGAAGG
CAATAGCTAGAAAATGAGAGGTGCCTTTAAAAAAAAAAATGCAGCCTTACAGTGAGGATGAAGATTGAGTTTGGGGAGGGGGTGGGAGGG
GGGGCACAGAGAGAGAGAGAGAGTTAGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCATGCATGCGTGTGTGTGTGTGTGTGT
GTGTTTACCAATCTGTGAAGGTCCTGATTTGTGACCATCAATGTCTTTTTAATGTATCTGCTCAACTTCTAGGACTTCAGGGGACATTTC
ATGCGCTTTGTGCTCTTCTGAGCACCATATATACTTTCCAAGAATTTTGAATGTGAATTCCTAGAAATTTCAGTAGAGAAAACAATAGCT
ATTCTTTAATTATAGTAAAGTTCAGGTAGAAGGAGAAATTATTTGTTCACCAAAATTATGGGATCTCATTAATGTTGGCTAAGTAAATGT
AATTTTTTAAAGGCTCACTTTTTAATACTTCATATATTTCCCTCTTACAAAACAGCATGTCATGAAGTTCTTATGTGGTAAAGATTCAAC
TAGTAAATATTTTTAGGTTAAATACCTGAACTAGTTAAAATTCCACCTAAGAATAGTCTTAAAATATTTAAAAAGCATCTCTCATATCTA
CCTCTTTGTCATTGCTGCCATTTTAACTGAAGCAAATCTTTATGACATCTGAAATGATGGTTGGATGCAATTAAAAAAAAATCTATGTTG
GTGCTTTTCTCAGGCTTTGTCATTTAAGTTATATTGTATTAAGATGTCACAAATCAGACTGAAAGGCTTAGAATTAATTTTGTTTTTCTT
TGAAAGAATTGCTTAAAATTAACCATCAATGTTTTTAGCGAGTGGAGATAATGAATCTTTGGTTGGTGTCTGTCTGTGTGATGTTTTCAA
CCAATAGCCAAATAATTATTGAACTTACATGAAAAAGAGTGCTAAGTATAATTTTATTTAGATTACTTTATTCTTTGAAAGTGACTACAA
GGCTATTAAGTACATAATCATTCATTTTATTTACTCAGAAGTTGCCTCTCCATTACTGTTAACTTGTTTAGTAATTTATATAATTGCAGT
ACTTTTAAGTGTTGGACACTGGGATTCAGGTTGTATACAAAGTAGTAGCTGACGAAAAATATGTATATTTTTGTGAAATGTATCAAGCCC
TAAAGTTCATTTTAGAGAAAGGCCCAGAAAAACGTATCTGTGTTTAAAAACAAAGGACAGGTCATTCGTCAATTTGAATCATTTTTACTT
TTGCCACTACAAACTTTTTAATTGGCAATATCCATCATCCAACTGGATCTTCATGTCAGTGTCAGGGATGCCAGGTTGACAAAGTATTTA
ACAGATCCTTTCAGTTTTTGTTTTGTTTTTTTAATTCTAAAAAAAACAAATGTTAGGCCAAACAGATCCCTAGATCCCACTCATTGATTC
TGGCGGTATTCCTAAAGTGGTGCTTAGGGGGTCAGAATTTTCTGGATCTTTGCTAATCCAAGCTTTAGATTTAATTTAACCAGGACCACA
TGCTTGTCATCTCTCTGATGCAAATTTTCAAAATCATTTTAATTTAGATTCTAATGTCTGCCTGGGTTTTTAACAGGCTGTGAACCAGTG
AGTGCCTTGTTAATGTAGAATGATTTTTCCCCCCTGGGTGGGTGTTAGTTAGCTCCTCTCTGAAAATGTCTCAGAGAATGGTATTTTAAT
TGACTTGTAGAGAGCTGCTAAATTTGTTATTATCAGCAATCAGAAAGTCTTTGGTCTACCACACATCTCCCTCCCTACTATCTCTTCATT
GTTTGGCTGAAGTTTGCCTCTTGTGAGAAAACAATACAACTCCCCTTCTCCACACACTTTTTTTCCAGCCCAGATTAATAGGTATCCCCT
ACCCTAATCCCAACTCTATGATCTAATACCTTTTTTAGGAGGAACCACTTCTTTTTAATATTGAAATCTGCTGGTTACTTTATGTTTTCT
CAAGTTCAGTTGACTAGAGCTGACCACAGGGTGTCATCAATTCAGATTCCTAAATAACCCTTTCTCTCCACACCCAGTCCTCCAGCTGGT
GAGCCCTGGGCCAGATTGTTTGATCTTCAGGTATTTTAAATTTTAGTTACATCAATTAATGTAAATTAATCCAAATGCTAATTTTTGTGG
TGCAAGAAGTTTCTTATGTAAATTCAGGGTATGGATAAGCTAATTAAGATATCCATCTTTGGTGGCTCTAAGTGTATTATTTGTTTTTAA
ATAAAGTGTACAAATATAGATAACATGCTATAGGTGTCTCATGAATTGGAATATTTGTCAGATTTGGGATCTAGCTGTGGCTTTACAGTA

>25665_25665_1_EIF2AK2-STRN_EIF2AK2_chr2_37341874_ENST00000405334_STRN_chr2_37152351_ENST00000263918_length(amino acids)=1120AA_BP=0
MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSKKEAKNAAAKLAVEILNKEKKAVSPLLLTTT
NSSEGLSMGNYIGLINRIAQKKRLTVNYEQCASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG
SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAKRSLAPRFDLPDMKETKYTVDKRKAEREVKA
LAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKG
VDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQAQIAFLQGERKGQENLKKDLVRRIKMLEYALK
QERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDK
NQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDF
LVTSEEGDNESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGVKRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRP
SSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALA
FHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSV
LRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRI
LTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTC

--------------------------------------------------------------
>25665_25665_2_EIF2AK2-STRN_EIF2AK2_chr2_37341874_ENST00000405334_STRN_chr2_37152351_ENST00000379213_length(transcript)=4379nt_BP=1254nt
ATGGCTGGTGATCTTTCAGCAGGTTTCTTCATGGAGGAACTTAATACATACCGTCAGAAGCAGGGAGTAGTACTTAAATATCAAGAACTG
CCTAATTCAGGACCTCCACATGATAGGAGGTTTACATTTCAAGTTATAATAGATGGAAGAGAATTTCCAGAAGGTGAAGGTAGATCAAAG
AAGGAAGCAAAAAATGCCGCAGCCAAATTAGCTGTTGAGATACTTAATAAGGAAAAGAAGGCAGTTAGTCCTTTATTATTGACAACAACG
AATTCTTCAGAAGGATTATCCATGGGGAATTACATAGGCCTTATCAATAGAATTGCCCAGAAGAAAAGACTAACTGTAAATTATGAACAG
TGTGCATCGGGGGTGCATGGGCCAGAAGGATTTCATTATAAATGCAAAATGGGACAGAAAGAATATAGTATTGGTACAGGTTCTACTAAA
CAGGAAGCAAAACAATTGGCCGCTAAACTTGCATATCTTCAGATATTATCAGAAGAAACCTCAGTGAAATCTGACTACCTGTCCTCTGGT
TCTTTTGCTACTACGTGTGAGTCCCAAAGCAACTCTTTAGTGACCAGCACACTCGCTTCTGAATCATCATCTGAAGGTGACTTCTCAGCA
GATACATCAGAGATAAATTCTAACAGTGACAGTTTAAACAGTTCTTCGTTGCTTATGAATGGTCTCAGAAATAATCAAAGGAAGGCAAAA
AGATCTTTGGCACCCAGATTTGACCTTCCTGACATGAAAGAAACAAAGTATACTGTGGACAAGAGGAAGGCGGAGCGTGAAGTAAAAGCA
TTGGCAAAACTTGATCATGTAAATATTGTTCACTACAATGGCTGTTGGGATGGATTTGATTATGATCCTGAGACCAGTGATGATTCTCTT
GAGAGCAGTGATTATGATCCTGAGAACAGCAAAAATAGTTCAAGGTCAAAGACTAAGTGCCTTTTCATCCAAATGGAATTCTGTGATAAA
GGGACCTTGGAACAATGGATTGAAAAAAGAAGAGGCGAGAAACTAGACAAAGTTTTGGCTTTGGAACTCTTTGAACAAATAACAAAAGGG
GTGGATTATATACATTCAAAAAAATTAATTCATAGAGATCTTAAGCCAAGTAATATATTCTTAGTAGATACAAAACAAGTAAAGATTGGA
GACTTTGGACTTGTAACATCTCTGAAAAATGATGGAAAGCGAACAAGGAGTAAGGGAACTTTGCGATACATGAGCCCAGAACAGGCCCAG
ATTGCCTTCCTGCAGGGAGAAAGGAAGGGCCAAGAAAATTTGAAGAAGGATCTTGTGAGGAGGATCAAAATGTTGGAGTATGCTCTTAAA
CAGGAAAGAGCCAAATACCACAAGTTGAAATACGGGACAGAATTGAATCAGGGAGATATGAAGCCTCCAAGCTATGATTCTGATGAAGGT
AATGAAACAGAAGTGCAGCCACAACAAAACAGCCAGTTAATGTGGAAACAAGGTCGACAACTACTCAGACAGTATCTACAGGAGGTGGGT
TATACAGATACTATTCTAGATGTGAAATCTAAACGAGTGCGAGCTTTGTTGGGCTTTTCAAGTGATGTCACGGACAGGGAAGATGACAAA
AATCAGGACTCAGTTGTAAATGGCACAGAGGCTGAAGTTAAAGAGACAGCAATGATTGCAAAATCTGAGTTAACAGATTCTGCCTCCGTG
CTGGATAATTTCAAATTCCTTGAAAGTGCAGCTGCAGATTTCAGTGATGAAGATGAAGATGATGATGTTGATGGAAGAGAGAAAAGCGTC
ATTGATACTTCAACAATTGTTAGGAAAAAAGCATTGCCTGACAGCGGTGAAGATCGAGATACAAAAGAAGCTCTAAAGGAGTTTGACTTC
TTGGTTACATCAGAGGAAGGAGACAATGAATCTAGAAGTGCAGGCGATGGAACAGACTGGGGGCCCAATAGGTCAAAACTACAAGATATG
CTTGCTAATTTGAGAGATGTTGATGAACTTCCTTCATTGCAGCCATCTGTGGGTTCACCTTCCAGACCCAGCAGCTCCAGGCTTCCTGAA
CATGAAATTAATAGGGCAGATGAAGTGGAAGCATTGACATTTCCTCCTTCTTCTGGAAAGTCATTCATCATGGGAGCAGATGAAGCCCTT
GAAAGTGAACTGGGACTTGGAGAACTAGCAGGCCTTACGGTGGCCAATGAAGCAGACTCACTAACTTATGATATAGCAAACAATAAAGAT
GCATTGAGGAAGACATGGAACCCTAAGTTTACATTGAGAAGTCACTTTGATGGCATCCGAGCCCTTGCTTTCCATCCCATTGAGCCTGTT
TTGATAACAGCATCAGAGGATCACACATTAAAAATGTGGAATTTACAGAAAACAGCCCCAGCCAAAAAGAGCACTTCTCTTGATGTAGAA
CCTATCTATACATTCAGAGCCCATAAAGGTCCAGTGCTTTGTGTGGTAATGAGCAGCAATGGTGAGCAGTGTTACAGTGGTGGTACTGAT
GGACTGATCCAGGGCTGGAATACCACTAATCCCAACATCGACCCCTATGATTCTTATGATCCTTCTGTTTTACGAGGCCCTCTGCTAGGC
CACACGGATGCAGTCTGGGGTTTGGCTTATAGTGCAGCACATCAGCGTTTGTTGTCCTGTTCAGCAGATGGCACTCTGCGTTTATGGAAT
ACAACTGAGGTTGCTCCAGCACTAAGTGTATTTAATGATACTAAAGAACTGGGAATCCCTGCCTCTGTGGATCTAGTGAGCAGTGACCCG
AGCCATATGGTAGCATCATTCAGCAAGGGATATACAAGCATTTTTAACATGGAAACACAACAACGCATTCTCACTTTAGAATCCAATGTA
GATACAACAGCCAACTCTTCCTGCCAAATAAATAGAGTCATCAGTCATCCTACTCTTCCGATCAGCATCACTGCTCATGAAGACAGGCAC
ATCAAATTCTATGATAACAATACAGGCAAACTGATCCACTCGATGGTAGCCCACCTAGAAGCTGTTACAAGTTTAGCAGTTGATCCCAAT
GGCCTTTACTTGATGTCTGGCAGTCATGACTGTTCAATACGTTTATGGAATCTAGAAAGTAAGACGTGTATCCAAGAATTCACAGCTCAT
CGAAAAAAGTTTGAAGAATCGATTCATGATGTAGCTTTCCACCCATCCAAATGCTATATAGCCAGTGCTGGAGCTGACGCACTGGCTAAA
GTCTTTGTATGACGCAATGCATCATCTTCACCTTCTAGCTGTTTATAAGTAATCAACTGCACACAAGAGATACAGAAGACGAGGGCAAGA
ATCATCTCGTCCTGCCCTTTTGTTCTGCTGAAGGAGCACAGAGAACATTTGTTGAAGTATAGTTTTGCAATTCATATACTGTTTTCTAAA
ACTAAGGTTTGTTCAGGTTGCTGCAAGCTCAGCTGAATCTGTGAGCCTGAGGTCTGTTTCAAATTTCTCCCCAATAGGCGCCTTTATTTC
TGAGGTGGTTCTAATTCGCTAGGCAGGCCTGAGCGAATACAAGTTTAGCTTGTCCCTGTTGAGTAAGTAGGGCATGCTACAATGGATAAT
TTAAAAGCTTGATAGCTGGGACTGAATAGAAGAAAACGGGAAACTTAGACCAAGTTCTCCCCTGAGAAATCTTGTTAAAACACATTAAGT
AGTCAAAATAGTAATCTTTATCATATCTGCCATATTAACCCCTTTGTGTATAATGACCAGGCAGTGTTAAACTGAGTTTTTAATTTGACT
CTCCTTTCAGCTGTTCACATAAAGCACCTGGCAAAGCATTTTACCTGTTAGGGGGAGAAAAATGCAATAATATGTTAAATATATTATTAT
TCAGAAATGCTAGACAAATAGTTTGCAAGCAGATTTCTATATTGTATTACAGTTTTGAAAACAGATTTGGTATCATTCTAAAGTTTAGCT
ATCAAGCACTCACCATTGTGAAGAATAGTTGATCGACTCTGCTTTTACTAACAGATTTAACTTATTCAGGTTTGAAATTCTGTTTATTTT
TAAGGGTAAACAGGGCATATCTCTTTAATAATTTCTATTTTAAAATTCACTTTATTCATGTGACATTTATAGTACCAGAGTGATTATTTC
ATACCAATGAAATCTTACTTTTCAGTGACTGAAAAGATAGAATTTATTTGCTAATAATCATTTATCAACACCCACCTAATCATGCTTCAG
ATGATCTGTGCTCTTTCTTCTTTGTCACGTTCAAGTTATCTGACATCTACCAAGAACAGTTCATAATTATTAATAGCCCAAAGAGTATGG

>25665_25665_2_EIF2AK2-STRN_EIF2AK2_chr2_37341874_ENST00000405334_STRN_chr2_37152351_ENST00000379213_length(amino acids)=1083AA_BP=0
MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSKKEAKNAAAKLAVEILNKEKKAVSPLLLTTT
NSSEGLSMGNYIGLINRIAQKKRLTVNYEQCASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG
SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAKRSLAPRFDLPDMKETKYTVDKRKAEREVKA
LAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKG
VDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQAQIAFLQGERKGQENLKKDLVRRIKMLEYALK
QERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDK
NQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDF
LVTSEEGDNESRSAGDGTDWGPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEAL
ESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVE
PIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWN
TTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRH
IKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EIF2AK2-STRN

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	EIF2AK2	chr2:37341874	chr2:37152351	ENST00000233057	-	14	17	266_551	459.0	552.0	TRAF5
Hgene	EIF2AK2	chr2:37341874	chr2:37152351	ENST00000395127	-	14	17	266_551	459.0	552.0	TRAF5
Hgene	EIF2AK2	chr2:37341874	chr2:37152351	ENST00000405334	-	11	14	266_551	418.0	511.0	TRAF5

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for EIF2AK2-STRN

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for EIF2AK2-STRN

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	EIF2AK2	C0021400	Influenza	1	CTD_human
Hgene	EIF2AK2	C0033578	Prostatic Neoplasms	1	CTD_human
Hgene	EIF2AK2	C0038220	Status Epilepticus	1	CTD_human
Hgene	EIF2AK2	C0270823	Petit mal status	1	CTD_human
Hgene	EIF2AK2	C0311335	Grand Mal Status Epilepticus	1	CTD_human
Hgene	EIF2AK2	C0376358	Malignant neoplasm of prostate	1	CTD_human
Hgene	EIF2AK2	C0393734	Complex Partial Status Epilepticus	1	CTD_human
Hgene	EIF2AK2	C0751522	Status Epilepticus, Subclinical	1	CTD_human
Hgene	EIF2AK2	C0751523	Non-Convulsive Status Epilepticus	1	CTD_human
Hgene	EIF2AK2	C0751524	Simple Partial Status Epilepticus	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:EIF2AK2-STRN (FusionGDB2 ID:HG5610TG6801)

Fusion Gene Summary for EIF2AK2-STRN

Fusion Gene ORF analysis for EIF2AK2-STRN

Fusion Genomic Features for EIF2AK2-STRN

Fusion Protein Features for EIF2AK2-STRN

Fusion Gene Sequence for EIF2AK2-STRN

Fusion Gene PPI Analysis for EIF2AK2-STRN

Related Drugs for EIF2AK2-STRN

Related Diseases for EIF2AK2-STRN

Fusion Gene Studies
in Kim Lab