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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PSMA7-GSTT1 (FusionGDB2 ID:HG5688TG2952)

Fusion Gene Summary for PSMA7-GSTT1

check button Fusion gene summary
Fusion gene informationFusion gene name: PSMA7-GSTT1
Fusion gene ID: hg5688tg2952
HgeneTgene
Gene symbol

PSMA7

GSTT1

Gene ID

5688

2952

Gene nameproteasome 20S subunit alpha 7glutathione S-transferase theta 1
SynonymsC6|HEL-S-276|HSPC|RC6-1|XAPC7-
Cytomap('PSMA7')('GSTT1')

20q13.33

22q11.23

Type of geneprotein-codingprotein-coding
Descriptionproteasome subunit alpha type-7epididymis secretory protein Li 276proteasome (prosome, macropain) subunit, alpha type, 7proteasome subunit RC6-1proteasome subunit XAPC7proteasome subunit alpha 4proteasome subunit alpha 7testicular tissue protein Liglutathione S-transferase theta-1GST class-theta-1glutathione transferase T1-1
Modification date2020032720200315
UniProtAcc.

P30711

Ensembl transtripts involved in fusion geneENST00000370858, ENST00000370873, 
ENST00000484488, ENST00000370861, 
Fusion gene scores* DoF score9 X 12 X 4=4323 X 2 X 3=18
# samples 123
** MAII scorelog2(12/432*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PSMA7 [Title/Abstract] AND GSTT1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPSMA7(60718263)-GSTT1(24379511), # samples:1
Anticipated loss of major functional domain due to fusion event.PSMA7-GSTT1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PSMA7-GSTT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PSMA7-GSTT1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PSMA7-GSTT1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGSTT1

GO:0006749

glutathione metabolic process

9307035|9434735|20097269



check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer221NPSMA7chr20

60718263

-GSTT1chr22

24379511

-


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Fusion Gene ORF analysis for PSMA7-GSTT1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000370858ENST00000439996PSMA7chr20

60718263

-GSTT1chr22

24379511

-
5CDS-5UTRENST00000370873ENST00000439996PSMA7chr20

60718263

-GSTT1chr22

24379511

-
5UTR-3CDSENST00000484488ENST00000248935PSMA7chr20

60718263

-GSTT1chr22

24379511

-
5UTR-5UTRENST00000484488ENST00000439996PSMA7chr20

60718263

-GSTT1chr22

24379511

-
Frame-shiftENST00000370858ENST00000248935PSMA7chr20

60718263

-GSTT1chr22

24379511

-
Frame-shiftENST00000370873ENST00000248935PSMA7chr20

60718263

-GSTT1chr22

24379511

-
intron-3CDSENST00000370861ENST00000248935PSMA7chr20

60718263

-GSTT1chr22

24379511

-
intron-5UTRENST00000370861ENST00000439996PSMA7chr20

60718263

-GSTT1chr22

24379511

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for PSMA7-GSTT1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for PSMA7-GSTT1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:60718263/:24379511)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GSTT1

P30711

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide. {ECO:0000269|PubMed:16298388, ECO:0000269|PubMed:20097269}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PSMA7-GSTT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PSMA7-GSTT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PSMA7-GSTT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGSTT1P30711DB00143GlutathioneSmall moleculeApproved|Investigational|Nutraceutical

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Related Diseases for PSMA7-GSTT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0036341Schizophrenia5PSYGENET
TgeneC0033578Prostatic Neoplasms4CTD_human
TgeneC0376358Malignant neoplasm of prostate4CTD_human
TgeneC0004403Autosome Abnormalities3CTD_human
TgeneC0008625Chromosome Aberrations3CTD_human
TgeneC0019193Hepatitis, Toxic3CTD_human
TgeneC0860207Drug-Induced Liver Disease3CTD_human
TgeneC1262760Hepatitis, Drug-Induced3CTD_human
TgeneC3658290Drug-Induced Acute Liver Injury3CTD_human
TgeneC4277682Chemical and Drug Induced Liver Injury3CTD_human
TgeneC4279912Chemically-Induced Liver Toxicity3CTD_human
TgeneC0007134Renal Cell Carcinoma2CTD_human
TgeneC0236733Amphetamine-Related Disorders2CTD_human
TgeneC0236804Amphetamine Addiction2CTD_human
TgeneC0236807Amphetamine Abuse2CTD_human
TgeneC0279702Conventional (Clear Cell) Renal Cell Carcinoma2CTD_human
TgeneC1266042Chromophobe Renal Cell Carcinoma2CTD_human
TgeneC1266043Sarcomatoid Renal Cell Carcinoma2CTD_human
TgeneC1266044Collecting Duct Carcinoma of the Kidney2CTD_human
TgeneC1306837Papillary Renal Cell Carcinoma2CTD_human
TgeneC0003949Asbestosis1CTD_human
TgeneC0005586Bipolar Disorder1PSYGENET
TgeneC0006826Malignant Neoplasms1CTD_human
TgeneC0007097Carcinoma1CTD_human
TgeneC0007114Malignant neoplasm of skin1CTD_human
TgeneC0011570Mental Depression1PSYGENET
TgeneC0011581Depressive disorder1PSYGENET
TgeneC0017636Glioblastoma1CTD_human
TgeneC0020538Hypertensive disease1CTD_human
TgeneC0022665Kidney Neoplasm1CTD_human
TgeneC0024121Lung Neoplasms1CTD_human
TgeneC0026764Multiple Myeloma1CTD_human
TgeneC0027651Neoplasms1CTD_human
TgeneC0034734Raynaud Disease1CTD_human
TgeneC0034735Raynaud Phenomenon1CTD_human
TgeneC0037286Skin Neoplasms1CTD_human
TgeneC0086692Benign Neoplasm1CTD_human
TgeneC0205696Anaplastic carcinoma1CTD_human
TgeneC0205697Carcinoma, Spindle-Cell1CTD_human
TgeneC0205698Undifferentiated carcinoma1CTD_human
TgeneC0205699Carcinomatosis1CTD_human
TgeneC0242379Malignant neoplasm of lung1CTD_human
TgeneC0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneC0334588Giant Cell Glioblastoma1CTD_human
TgeneC0400966Non-alcoholic Fatty Liver Disease1CTD_human
TgeneC0403823Asthenozoospermia1CTD_human
TgeneC0740457Malignant neoplasm of kidney1CTD_human
TgeneC1449861Micronuclei, Chromosome-Defective1CTD_human
TgeneC1449862Micronuclei, Genotoxicant-Induced1CTD_human
TgeneC1621958Glioblastoma Multiforme1CTD_human
TgeneC2930617Pulmonary Fibrosis - from Asbestos Exposure1CTD_human
TgeneC3241937Nonalcoholic Steatohepatitis1CTD_human