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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNFX1-MPO (FusionGDB2 ID:HG57169TG4353)

Fusion Gene Summary for ZNFX1-MPO

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNFX1-MPO
Fusion gene ID: hg57169tg4353
HgeneTgene
Gene symbol

ZNFX1

MPO

Gene ID

57169

4353

Gene namezinc finger NFX1-type containing 1myeloperoxidase
Synonyms--
Cytomap('ZNFX1')('MPO')

20q13.13

17q22

Type of geneprotein-codingprotein-coding
DescriptionNFX1-type zinc finger-containing protein 1myeloperoxidase
Modification date2020031320200329
UniProtAcc.

P05164

Ensembl transtripts involved in fusion geneENST00000371752, ENST00000371754, 
ENST00000396105, ENST00000469991, 
Fusion gene scores* DoF score7 X 8 X 4=22412 X 18 X 3=648
# samples 812
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/648*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNFX1 [Title/Abstract] AND MPO [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNFX1(47887830)-MPO(56355396), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMPO

GO:0034374

low-density lipoprotein particle remodeling

10772654

TgeneMPO

GO:0042744

hydrogen peroxide catabolic process

10772654|11907569

TgeneMPO

GO:0055114

oxidation-reduction process

10772654



check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABQ335856ZNFX1chr20

47887830

-MPOchr17

56355396

-


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Fusion Gene ORF analysis for ZNFX1-MPO

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000371752ENST00000225275ZNFX1chr20

47887830

-MPOchr17

56355396

-
intron-3CDSENST00000371752ENST00000340482ZNFX1chr20

47887830

-MPOchr17

56355396

-
intron-3CDSENST00000371754ENST00000225275ZNFX1chr20

47887830

-MPOchr17

56355396

-
intron-3CDSENST00000371754ENST00000340482ZNFX1chr20

47887830

-MPOchr17

56355396

-
intron-3CDSENST00000396105ENST00000225275ZNFX1chr20

47887830

-MPOchr17

56355396

-
intron-3CDSENST00000396105ENST00000340482ZNFX1chr20

47887830

-MPOchr17

56355396

-
intron-3CDSENST00000469991ENST00000225275ZNFX1chr20

47887830

-MPOchr17

56355396

-
intron-3CDSENST00000469991ENST00000340482ZNFX1chr20

47887830

-MPOchr17

56355396

-
intron-5UTRENST00000371752ENST00000578493ZNFX1chr20

47887830

-MPOchr17

56355396

-
intron-5UTRENST00000371754ENST00000578493ZNFX1chr20

47887830

-MPOchr17

56355396

-
intron-5UTRENST00000396105ENST00000578493ZNFX1chr20

47887830

-MPOchr17

56355396

-
intron-5UTRENST00000469991ENST00000578493ZNFX1chr20

47887830

-MPOchr17

56355396

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ZNFX1-MPO


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for ZNFX1-MPO


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:47887830/:56355396)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MPO

P05164

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. {ECO:0000269|PubMed:9922160}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ZNFX1-MPO


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ZNFX1-MPO


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNFX1-MPO


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMPOP05164DB00244MesalazineSmall moleculeApproved
TgeneMPOP05164DB00535CefdinirInhibitorSmall moleculeApproved
TgeneMPOP05164DB00583LevocarnitineSmall moleculeApproved|Investigational
TgeneMPOP05164DB01065MelatoninInhibitorSmall moleculeApproved|Nutraceutical|Vet_approved
TgeneMPOP05164DB04821NomifensineSmall moleculeApproved|Withdrawn

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Related Diseases for ZNFX1-MPO


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0035126Reperfusion Injury6CTD_human
TgeneC0021368Inflammation5CTD_human
TgeneC0398595Myeloperoxidase Deficiency5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0009324Ulcerative Colitis3CTD_human
TgeneC0003873Rheumatoid Arthritis2CTD_human
TgeneC0023891Liver Cirrhosis, Alcoholic2CTD_human
TgeneC0001969Alcoholic Intoxication1PSYGENET
TgeneC0002152Alloxan Diabetes1CTD_human
TgeneC0002395Alzheimer's Disease1CTD_human
TgeneC0003129Anoxemia1CTD_human
TgeneC0003130Anoxia1CTD_human
TgeneC0003865Arthritis, Adjuvant-Induced1CTD_human
TgeneC0005398Cholestasis, Extrahepatic1CTD_human
TgeneC0005684Malignant neoplasm of urinary bladder1CTD_human
TgeneC0005695Bladder Neoplasm1CTD_human
TgeneC0006111Brain Diseases1CTD_human
TgeneC0007222Cardiovascular Diseases1CTD_human
TgeneC0007786Brain Ischemia1CTD_human
TgeneC0009319Colitis1CTD_human
TgeneC0011265Presenile dementia1CTD_human
TgeneC0011574Involutional Depression1CTD_human
TgeneC0011609Drug Eruptions1CTD_human
TgeneC0011853Diabetes Mellitus, Experimental1CTD_human
TgeneC0022593Keratosis1CTD_human
TgeneC0022594Keratosis Blennorrhagica1CTD_human
TgeneC0022658Kidney Diseases1CTD_human
TgeneC0022660Kidney Failure, Acute1CTD_human
TgeneC0024115Lung diseases1CTD_human
TgeneC0024121Lung Neoplasms1CTD_human
TgeneC0028797Occupational Diseases1CTD_human
TgeneC0030305Pancreatitis1CTD_human
TgeneC0032927Precancerous Conditions1CTD_human
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0036982Shock, Hemorrhagic1CTD_human
TgeneC0038433Streptozotocin Diabetes1CTD_human
TgeneC0040954Infection by Trichuris trichiura1CTD_human
TgeneC0042109Urticaria1CTD_human
TgeneC0085584Encephalopathies1CTD_human
TgeneC0086501Keratoma1CTD_human
TgeneC0242184Hypoxia1CTD_human
TgeneC0242379Malignant neoplasm of lung1CTD_human
TgeneC0276496Familial Alzheimer Disease (FAD)1CTD_human
TgeneC0282313Condition, Preneoplastic1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human
TgeneC0406537Morbilliform Drug Reaction1CTD_human
TgeneC0494463Alzheimer Disease, Late Onset1CTD_human
TgeneC0546126Acute Confusional Senile Dementia1CTD_human
TgeneC0700292Hypoxemia1CTD_human
TgeneC0750900Alzheimer's Disease, Focal Onset1CTD_human
TgeneC0750901Alzheimer Disease, Early Onset1CTD_human
TgeneC0917798Cerebral Ischemia1CTD_human
TgeneC0971858Arthritis, Collagen-Induced1CTD_human
TgeneC0993582Arthritis, Experimental1CTD_human
TgeneC1269683Major Depressive Disorder1CTD_human
TgeneC1565662Acute Kidney Insufficiency1CTD_human
TgeneC1571983Involutional paraphrenia1CTD_human
TgeneC1571984Psychosis, Involutional1CTD_human
TgeneC2239176Liver carcinoma1CTD_human
TgeneC2609414Acute kidney injury1CTD_human