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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:BIRC6-NBAS (FusionGDB2 ID:HG57448TG51594) |
Fusion Gene Summary for BIRC6-NBAS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BIRC6-NBAS | Fusion gene ID: hg57448tg51594 | Hgene | Tgene | Gene symbol | BIRC6 | NBAS | Gene ID | 57448 | 51594 |
| Gene name | baculoviral IAP repeat containing 6 | NBAS subunit of NRZ tethering complex | |
| Synonyms | APOLLON|BRUCE | ILFS2|NAG|SOPH | |
| Cytomap | ('BIRC6')('NBAS') 2p22.3 | 2p24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | baculoviral IAP repeat-containing protein 6BIR repeat-containing ubiquitin-conjugating enzymeRING-type E3 ubiquitin transferase BIRC6ubiquitin-conjugating BIR-domain enzyme apollon | neuroblastoma-amplified sequenceNAG/BC035112 fusionNAG/FAM49A fusionneuroblastoma amplified sequenceneuroblastoma-amplified gene protein | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000421745, | ||
| Fusion gene scores | * DoF score | 21 X 23 X 16=7728 | 15 X 15 X 6=1350 |
| # samples | 33 | 15 | |
| ** MAII score | log2(33/7728*10)=-4.54955716458996 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/1350*10)=-3.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: BIRC6 [Title/Abstract] AND NBAS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | BIRC6(32774548)-NBAS(15679480), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | BIRC6-NBAS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BIRC6-NBAS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BIRC6-NBAS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BIRC6-NBAS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across BIRC6 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across NBAS (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-E2-A14S | BIRC6 | chr2 | 32774548 | + | NBAS | chr2 | 15679480 | - |
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Fusion Gene ORF analysis for BIRC6-NBAS |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000421745 | ENST00000281513 | BIRC6 | chr2 | 32774548 | + | NBAS | chr2 | 15679480 | - |
| In-frame | ENST00000421745 | ENST00000441750 | BIRC6 | chr2 | 32774548 | + | NBAS | chr2 | 15679480 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000421745 | BIRC6 | chr2 | 32774548 | + | ENST00000441750 | NBAS | chr2 | 15679480 | - | 19795 | 13278 | 134 | 19654 | 6506 |
| ENST00000421745 | BIRC6 | chr2 | 32774548 | + | ENST00000281513 | NBAS | chr2 | 15679480 | - | 20154 | 13278 | 134 | 20014 | 6626 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000421745 | ENST00000441750 | BIRC6 | chr2 | 32774548 | + | NBAS | chr2 | 15679480 | - | 0.001208025 | 0.998792 |
| ENST00000421745 | ENST00000281513 | BIRC6 | chr2 | 32774548 | + | NBAS | chr2 | 15679480 | - | 0.001118083 | 0.9988819 |
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Fusion Genomic Features for BIRC6-NBAS |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for BIRC6-NBAS |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:32774548/chr2:15679480) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | BIRC6 | chr2:32774548 | chr2:15679480 | ENST00000421745 | + | 65 | 74 | 1660_1668 | 4381 | 4858.0 | Compositional bias | Note=Poly-Ala |
| Hgene | BIRC6 | chr2:32774548 | chr2:15679480 | ENST00000421745 | + | 65 | 74 | 30_36 | 4381 | 4858.0 | Compositional bias | Note=Poly-Ala |
| Hgene | BIRC6 | chr2:32774548 | chr2:15679480 | ENST00000421745 | + | 65 | 74 | 284_358 | 4381 | 4858.0 | Repeat | Note=BIR |
| Tgene | NBAS | chr2:32774548 | chr2:15679480 | ENST00000281513 | 5 | 52 | 1421_1425 | 126 | 2372.0 | Compositional bias | Note=Poly-Thr | |
| Tgene | NBAS | chr2:32774548 | chr2:15679480 | ENST00000281513 | 5 | 52 | 2242_2247 | 126 | 2372.0 | Compositional bias | Note=Poly-Leu | |
| Tgene | NBAS | chr2:32774548 | chr2:15679480 | ENST00000441750 | 5 | 50 | 1421_1425 | 126 | 2252.0 | Compositional bias | Note=Poly-Thr | |
| Tgene | NBAS | chr2:32774548 | chr2:15679480 | ENST00000441750 | 5 | 50 | 2242_2247 | 126 | 2252.0 | Compositional bias | Note=Poly-Leu | |
| Tgene | NBAS | chr2:32774548 | chr2:15679480 | ENST00000281513 | 5 | 52 | 130_169 | 126 | 2372.0 | Repeat | Note=WD 1 | |
| Tgene | NBAS | chr2:32774548 | chr2:15679480 | ENST00000281513 | 5 | 52 | 316_355 | 126 | 2372.0 | Repeat | Note=WD 2 | |
| Tgene | NBAS | chr2:32774548 | chr2:15679480 | ENST00000441750 | 5 | 50 | 130_169 | 126 | 2252.0 | Repeat | Note=WD 1 | |
| Tgene | NBAS | chr2:32774548 | chr2:15679480 | ENST00000441750 | 5 | 50 | 316_355 | 126 | 2252.0 | Repeat | Note=WD 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | BIRC6 | chr2:32774548 | chr2:15679480 | ENST00000421745 | + | 65 | 74 | 4573_4740 | 4381 | 4858.0 | Domain | UBC core |
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Fusion Gene Sequence for BIRC6-NBAS |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >9762_9762_1_BIRC6-NBAS_BIRC6_chr2_32774548_ENST00000421745_NBAS_chr2_15679480_ENST00000281513_length(transcript)=20154nt_BP=13278nt TCCCTGCTTCTCCCCCTCTCCCGTCAGCCTCCCTCCGAGTTTGGCCCCTCCGGCCGGGCGATCGACGTTCCGCGTGCGTGCGGGCGCCTG ACTTCACTTCCGGCTAACGCGCTCGGCTTGCCCCCTGGCCCCGGATGGTGACTGGTGGTGGTGCTGCACCTCCCGGGACTGTCACTGAGC CGCTTCCCAGTGTGATTGTGCTGAGCGCAGGCCGGAAGATGGCGGCTGCGGCTGCGGCGGCCTCGGGCCCCGGCTGCTCCTCGGCGGCGG GGGCGGGGGCGGCCGGGGTCTCAGAGTGGCTGGTGCTGCGGGACGGCTGCATGCACTGCGACGCCGACGGGCTGCACAGCCTGTCCTACC ACCCTGCGCTCAACGCCATCCTGGCCGTCACTAGCCGCGGGACCATCAAAGTCATCGACGGCACCTCGGGGGCCACACTGCAGGCCTCCG CGCTCAGTGCTAAACCAGGTGGACAGGTGAAATGTCAGTATATCTCTGCTGTGGATAAAGTTATATTTGTGGATGATTATGCAGTAGGGT GTAGGAAGGACCTTAATGGAATCTTGTTGTTAGACACTGCTCTGCAAACTCCAGTTTCAAAGCAGGATGATGTGGTTCAGCTTGAATTAC CCGTTACAGAGGCACAGCAGCTCTTATCAGCATGTTTAGAAAAGGTAGATATTTCTAGTACAGAGGGTTATGATTTGTTCATCACACAGC TCAAAGATGGTTTAAAAAATACATCTCATGAGACTGCAGCAAACCACAAAGTTGCTAAGTGGGCCACAGTTACATTTCATCTTCCTCATC ATGTGTTGAAGTCCATTGCCAGTGCCATTGTAAATGAACTCAAGAAAATAAATCAAAATGTTGCTGCCTTACCTGTGGCGTCCTCAGTGA TGGACAGATTGTCTTACCTCTTACCTAGTGCACGTCCAGAACTCGGAGTGGGGCCAGGCCGTTCTGTAGACAGATCACTGATGTATAGTG AAGCTAACAGACGGGAGACATTTACCTCATGGCCTCATGTAGGCTATAGGTGGGCACAACCAGATCCCATGGCTCAAGCTGGATTTTATC ATCAGCCTGCCTCATCTGGAGATGATAGAGCCATGTGTTTTACTTGTAGTGTATGCCTCGTTTGTTGGGAACCTACTGATGAACCTTGGT CTGAACACGAAAGACATTCCCCAAACTGCCCATTTGTGAAAGGTGAGCACACACAGAATGTGCCATTGTCAGTCACTCTTGCAACAAGTC CTGCACAGTTTCCTTGTACGGATGGAACTGACAGAATATCTTGCTTTGGGTCGGGGAGCTGCCCTCATTTTCTAGCTGCTGCAACTAAAC GAGGAAAGATCTGCATATGGGATGTTTCCAAACTTATGAAGGTGCACTTAAAGTTTGAAATTAATGCCTATGATCCAGCAATTGTACAAC AGCTTATTCTATCAGGAGACCCAAGCTCAGGAGTTGATTCAAGGAGACCAACTTTGGCGTGGCTGGAGGACTCCTCTAGTTGCTCAGATA TACCAAAATTGGAAGGAGATAGTGATGATTTACTGGAGGATTCAGACAGTGAAGAGCATTCCAGATCAGATTCTGTGACAGGGCATACAT CACAGAAGGAAGCCATGGAAGTAAGCCTTGATATAACAGCACTCAGCATTCTCCAACAGCCAGAAAAACTTCAGTGGGAGATTGTTGCAA ATGTGCTTGAAGATACTGTTAAGGATCTTGAAGAACTTGGGGCAAATCCTTGTTTAACAAACTCTAAGAGTGAAAAGACAAAGGAAAAGC ACCAGGAGCAACACAACATTCCTTTTCCATGTTTATTAGCTGGAGGTTTATTAACATATAAATCTCCTGCTACCTCACCCATTAGTAGTA ATTCTCACAGGTCACTGGATGGTTTAAGCAGAACTCAGGGTGAAAGTATATCAGAACAAGGGTCAACTGACAATGAATCCTGCACTAATT CAGAACTAAATTCTCCTCTGGTAAGGAGGACTTTACCGGTTTTGCTTCTTTATAGCATCAAGGAATCTGATGAGAAAGCAGGAAAGATCT TTTCACAGATGAACAATATTATGAGTAAAAGTTTGCATGATGATGGTTTTACTGTTCCACAGATTATTGAAATGGAGCTGGATAGTCAGG AGCAGTTGTTATTGCAGGATCCTCCTGTGACTTACATTCAGCAATTTGCAGATGCAGCAGCCAACCTTACCTCTCCGGATTCTGAGAAGT GGAACTCTGTGTTTCCCAAGCCTGGGACTTTGGTTCAGTGCTTGAGGCTGCCAAAGTTTGCAGAGGAGGAGAATCTTTGTATAGACTCAA TAACTCCTTGTGCTGACGGAATTCATTTGTTGGTAGGACTGCGGACATGCCCTGTTGAATCCTTGAGTGCAATAAATCAAGTAGAGGCCT TGAATAATTTAAATAAATTAAACTCTGCACTATGTAATAGACGGAAAGGTGAGCTGGAATCAAATCTTGCTGTAGTGAATGGTGCAAATA TTAGTGTAATCCAACATGAATCACCAGCAGATGTACAGACTCCTTTAATAATTCAGCCTGAGCAGAGGAATGTTAGTGGTGGATATTTAG TGCTTTATAAAATGAATTATGCCACTCGGATAGTGACTTTAGAAGAGGAGCCAATAAAAATACAACATATCAAAGATCCCCAGGACACAA TTACCTCGCTCATTTTGCTTCCACCCGATATATTGGATAATCGAGAGGATGACTGTGAGGAACCTATTGAGGACATGCAGTTAACCTCAA AGAATGGTTTTGAGAGAGAAAAAACGTCTGACATTTCTACTCTTGGACACCTGGTAATAACCACTCAGGGAGGATATGTAAAAATACTAG ATCTTTCAAACTTTGAAATTTTGGCCAAAGTGGAGCCTCCCAAAAAGGAGGGCACTGAGGAACAGGACACATTTGTTTCTGTGATTTACT GTTCTGGCACAGACAGGCTGTGTGCATGCACCAAAGGTGGTGAGCTTCATTTTCTCCAAATTGGAGGAACCTGTGATGATATTGATGAAG CTGATATACTAGTGGATGGATCTCTTTCTAAAGGAATAGAACCATCTTCAGAAGGTTCCAAACCTTTATCAAATCCTTCAAGTCCTGGCA TTTCAGGAGTTGATTTATTGGTGGACCAGCCATTCACCCTTGAAATCTTGACATCCCTAGTGGAGCTAACCCGCTTTGAGACTTTGACTC CAAGGTTTTCAGCGACTGTTCCTCCATGCTGGGTAGAAGTTCAACAAGAACAGCAGCAAAGGAGGCATCCTCAACATTTGCATCAGCAAC ACCATGGTGATGCTGCTCAGCATACTCGAACTTGGAAACTACAGACCGACAGCAACAGCTGGGATGAACATGTATTTGAATTAGTACTAC CTAAAGCTTGTATGGTTGGACATGTGGACTTCAAATTCGTTTTGAACTCAAACATCACCAATATTCCACAGATACAAGTGACACTGCTGA AAAATAAAGCTCCAGGATTAGGGAAAGTCAATGCTCTTAACATTGAAGTGGAACAAAATGGGAAACCGTCCCTGGTTGATTTGAATGAAG AAATGCAGCACATGGATGTAGAGGAATCACAGTGTCTTAGATTATGTCCATTTTTGGAGGATCATAAAGAAGACATTCTATGTGGGCCAG TATGGCTTGCTAGTGGCCTTGATCTATCAGGGCATGCTGGAATGTTGACGTTAACAAGCCCCAAACTTGTTAAAGGTATGGCAGGAGGAA AATATCGTTCGTTTTTAATCCATGTCAAGGCAGTGAATGAAAGAGGAACAGAAGAGATTTGTAATGGTGGTATGCGTCCTGTAGTAAGGC TTCCATCCCTAAAACACCAGAGTAACAAGGGTTATTCACTTGCTTCACTTTTGGCTAAAGTTGCAGCAGGCAAGGAAAAATCATCTAATG TTAAGAATGAAAATACAAGTGGCACCCGTAAATCTGAAAACCTCCGGGGCTGTGATTTACTTCAAGAGGTCTCAGTCACCATTCGAAGAT TTAAGAAAACCTCAATTTCTAAGGAAAGAGTGCAACGATGTGCCATGTTACAGTTTTCAGAATTTCATGAGAAGCTTGTTAATACTCTTT GCAGAAAAACAGATGATGGCCAGATCACAGAACATGCCCAGAGCCTTGTGTTGGATACTCTCTGTTGGTTAGCTGGAGTTCATTCAAATG GACCCGGAAGCTCAAAGGAAGGAAATGAGAACCTACTTTCAAAAACACGAAAATTTCTGTCAGACATCGTACGTGTTTGCTTCTTTGAGG CAGGACGAAGTATAGCCCATAAGTGTGCCCGATTTCTAGCCTTGTGCATTAGTAATGGCAAATGTGACCCATGTCAACCAGCATTTGGAC CTGTTCTGTTGAAGGCTTTACTTGATAATATGTCATTTTTACCTGCAGCAACAACTGGTGGTTCTGTCTATTGGTATTTTGTCTTACTGA ATTATGTGAAAGATGAAGATCTGGCTGGATGCAGTACAGCTTGTGCATCTTTGCTTACTGCAGTGTCCAGACAGTTACAGGACAGGCTAA CACCAATGGAGGCTTTACTTCAGACAAGATATGGATTATATAGCTCACCATTTGATCCAGTCCTCTTTGATTTGGAGATGAGTGGCTCTT CTTGTAAAAATGTTTATAACAGCAGCATTGGTGTCCAGTCAGATGAAATTGATTTATCAGATGTCCTTTCAGGAAATGGAAAGGTCAGTA GTTGCACAGCTGCTGAGGGTAGTTTCACATCTCTCACTGGACTTTTGGAAGTTGAACCTCTGCACTTTACTTGTGTGTCAACTAGTGATG GAACCAGAATAGAAAGGGATGATGCAATGAGTTCCTTCGGGGTTACTCCTGCAGTAGGTGGACTATCATCTGGGACAGTTGGGGAAGCCT CGACAGCCCTGAGTTCAGCAGCCCAGGTAGCTTTGCAGTCTCTCTCTCATGCAATGGCTTCAGCCGAGCAACAGCTACAGGTGCTGCAAG AGAAACAGCAGCAGCTTTTGAAGCTTCAGCAACAGAAAGCAAAGCTGGAAGCCAAGTTACATCAGACAACAGCTGCAGCAGCTGCAGCAG CATCAGCAGTAGGTCCTGTTCACAACTCTGTGCCTTCCAACCCAGTGGCTGCCCCTGGATTCTTCATTCATCCATCTGATGTTATTCCAC CCACTCCAAAAACAACACCTCTTTTTATGACTCCACCACTCACTCCACCCAATGAAGCAGTTTCCGTTGTGATTAATGCCGAACTTGCAC AGCTTTTCCCAGGCTCAGTCATTGATCCCCCAGCAGTCAATCTTGCTGCACATAACAAAAATTCCAACAAGTCCAGAATGAATCCACTTG GTTCTGGTCTAGCCCTTGCAATTTCTCATGCTTCACATTTTCTTCAACCTCCGCCTCACCAGTCCATTATTATAGAGCGAATGCATTCAG GAGCAAGAAGATTTGTGACCTTGGATTTTGGGAGGCCTATATTGTTGACTGATGTATTGATTCCCACTTGTGGAGACTTGGCCTCTTTGT CAATTGACATTTGGACATTAGGAGAAGAGGTGGATGGAAGGCGGTTGGTAGTGGCAACTGATATAAGCACTCATTCACTAATTCTTCATG ACTTAATACCACCTCCCGTGTGCAGATTCATGAAGATCACTGTTATTGGACGTTACGGGAGTACAAATGCCAGAGCCAAAATCCCATTAG GATTTTACTATGGTCATACCTACATCTTGCCTTGGGAAAGTGAACTGAAGTTAATGCATGATCCTCTAAAGGGAGAGGGAGAATCTGCAA ACCAGCCAGAAATTGACCAGCATTTAGCAATGATGGTTGCTTTGCAGGAGGATATACAGTGCAGGTATAACTTGGCTTGTCATCGTCTGG AAACCCTTTTGCAAAGTATTGATCTTCCTCCTCTAAACAGTGCTAACAATGCACAGTACTTTTTACGAAAACCAGATAAGGCAGTTGAGG AAGACAGTAGGGTTTTTTCTGCTTATCAAGATTGTATTCAGCTACAGCTTCAACTAAATTTGGCTCATAATGCAGTGCAGAGGCTCAAAG TGGCGCTAGGTGCAAGCCGGAAGATGTTGAGTGAAACATCAAATCCAGAAGATTTAATTCAGACATCTTCCACAGAGCAGTTACGTACTA TCATCAGATATTTACTGGACACTTTGCTCAGCCTGCTTCATGCTTCTAATGGACACTCTGTTCCTGCAGTTTTGCAGAGCACATTTCATG CCCAGGCCTGTGAAGAGCTCTTTAAACACTTGTGCATCAGTGGAACCCCAAAGATACGGTTACATACTGGTCTTCTTCTTGTTCAACTGT GTGGTGGTGAAAGGTGGTGGGGTCAATTTCTTTCTAATGTCCTTCAGGAATTGTACAATTCGGAACAGCTTCTCATCTTTCCACAGGATA GGGTCTTCATGTTACTTTCCTGCATTGGTCAAAGATCACTTAGTAATAGTGGAGTATTAGAAAGCTTACTTAATCTCTTGGATAATTTAT TGTCACCTCTTCAGCCACAGTTACCCATGCATAGGAGGACAGAAGGAGTACTAGATATTCCCATGATCAGTTGGGTTGTTATGCTGGTGT CCAGGTTGCTGGATTATGTGGCAACTGTTGAAGATGAAGCAGCAGCTGCAAAGAAACCTTTGAATGGTAATCAGTGGAGTTTTATTAACA ATAATCTACACACTCAGAGCTTAAATAGATCTTCTAAAGGCAGCAGTAGCCTTGATAGATTATATTCCAGAAAAATCAGAAAGCAGCTTG TTCATCATAAACAGCAACTTAACCTACTAAAAGCAAAGCAGAAGGCATTGGTAGAACAGATGGAAAAAGAAAAAATACAAAGTAACAAAG GATCATCATATAAACTCCTGGTAGAACAAGCAAAACTAAAGCAGGCCACTTCAAAGCACTTTAAGGATTTAATTCGTTTACGTCGGACAG CAGAATGGTCCCGTTCTAATTTAGACACAGAAGTTACAACAGCAAAAGAAAGTCCTGAGATAGAACCACTTCCATTTACTCTGGCCCATG AGCGTTGTATCTCAGTAGTCCAGAAACTTGTTCTGTTTCTTCTCTCCATGGACTTTACATGTCATGCAGATCTCTTATTGTTTGTTTGTA AGGTTCTTGCACGCATTGCAAATGCCACGAGGCCAACTATTCATCTGTGTGAGATTGTGAACGAACCCCAGCTGGAAAGACTGCTGTTAC TTTTGGTTGGAACTGACTTCAATAGAGGAGATATATCTTGGGGTGGTGCTTGGGCTCAGTATTCCTTAACTTGCATGCTACAAGATATTT TAGCAGGAGAATTACTGGCTCCAGTAGCCGCAGAAGCCATGGAGGAAGGAACAGTGGGTGATGATGTAGGTGCGACAGCTGGTGACTCTG ATGACTCCCTTCAACAGTCCTCAGTTCAGTTGCTGGAAACTATAGATGAACCTTTGACACATGACATAACAGGTGCACCTCCTCTGTCCT CTTTGGAAAAAGATAAAGAAATTGACCTTGAGTTACTTCAGGATCTAATGGAAGTTGACATTGATCCTTTAGATATTGATTTGGAAAAGG ACCCTCTTGCAGCCAAGGTTTTTAAGCCAATAAGCAGTACATGGTATGATTATTGGGGTGCTGATTATGGGACCTACAATTACAACCCTT ACATTGGAGGTCTGGGAATTCCTGTAGCAAAGCCACCAGCAAACACGGAGAAGAACGGATCACAGACAGTTAGCGTTTCAGTCTCTCAGG CCCTGGATGCTCGCCTAGAAGTTGGACTTGAACAGCAAGCAGAACTGATGTTGAAAATGATGTCTACTCTGGAGGCAGATTCCATTTTAC AGGCATTAACAAATACATCTCCTACATTATCACAGTCTCCCACTGGAACAGATGATTCACTTCTAGGGGGTTTACAAGCAGCAAACCAAA CCAGCCAGCTTATTATACAGTTATCATCTGTCCCAATGTTAAATGTTTGTTTCAACAAACTTTTTTCCATGCTTCAAGTCCATCATGTTC AGTTGGAGTCACTTCTCCAATTGTGGCTCACACTGAGCCTGAATTCTAGTTCAACTGGAAACAAAGAAAATGGAGCAGACATATTTTTAT ATAATGCTAATAGGATACCTGTTATTTCATTAAATCAAGCATCAATAACTAGCTTTCTCACAGTGTTAGCTTGGTATCCCAATACTTTGC TCCGGACATGGTGCCTTGTGCTTCATAGCCTAACACTCATGACAAACATGCAGCTTAATTCTGGTTCCAGCAGTGCCATTGGAACTCAGG AGAGTACTGCTCATTTGTTGGTTTCAGATCCAAACCTAATTCATGTATTAGTGAAATTTCTTTCTGGCACCAGTCCACATGGAACAAATC AACACAGTCCACAGGTTGGTCCTACAGCTACACAAGCTATGCAAGAATTTCTTACTCGATTACAAGTGCATCTTTCTTCAACATGTCCTC AGATATTCAGTGAATTTTTGCTCAAGCTAATTCATATACTTTCAACTGAAAGGGGTGCTTTCCAGACAGGCCAAGGACCTCTCGATGCCC AAGTGAAGCTCTTAGAATTCACTCTGGAGCAGAATTTTGAAGTCGTTTCAGTTAGTACTATTTCTGCCGTGATAGAATCGGTTACATTTT TAGTGCACCACTATATCACTTGCTCAGACAAAGTAATGTCAAGAAGTGGATCAGATAGCTCCGTGGGTGCTCGAGCATGCTTTGGGGGAC TCTTTGCCAATCTTATTCGTCCGGGTGATGCAAAAGCAGTTTGTGGCGAAATGACAAGAGATCAACTCATGTTTGATTTGTTAAAACTTG TTAACATTTTAGTGCAGCTGCCTCTTTCAGGCAATAGGGAATACAGTGCAAGAGTGTCTGTGACCACAAATACAACAGATAGTGTTTCAG ATGAAGAAAAAGTCTCAGGAGGCAAAGATGGCAATGGAAGCAGTACCAGTGTTCAAGGATCGCCTGCATATGTTGCTGACTTAGTCTTAG CCAACCAACAAATTATGAGCCAGATTTTGTCTGCTCTGGGCCTGTGTAATAGCAGTGCCATGGCAATGATAATTGGAGCAAGTGGATTAC ATCTCACTAAACATGAAAACTTTCATGGTGGGTTGGATGCCATATCAGTTGGGGATGGATTATTTACCATACTGACAACCCTTAGTAAAA AAGCTTCTACAGTCCACATGATGCTGCAGCCAATTTTAACATACATGGCCTGTGGATATATGGGCAGACAAGGCTCTCTTGCTACTTGCC AGTTATCTGAGCCATTATTGTGGTTCATTTTGAGAGTATTGGATACTAGTGATGCCTTGAAAGCATTTCATGATATGGGTGGTGTTCAGC TCATATGCAATAATATGGTTACTAGTACAAGGGCTATTGTGAACACTGCAAGAAGTATGGTATCAACTATTATGAAATTTCTTGACTCTG GTCCAAATAAAGCTGTTGACAGCACATTGAAAACAAGAATACTAGCTTCTGAGCCTGACAATGCTGAAGGGATTCATAACTTTGCACCCC TCGGTACAATCACATCTAGCAGTCCTACTGCCCAACCAGCTGAAGTGCTATTGCAGGCCACACCTCCTCACAGAAGAGCTCGCTCTGCTG CTTGGTCCTACATCTTTCTTCCAGAGGAGGCTTGGTGTGACCTTACCATTCACCTTCCTGCAGCAGTGCTGCTTAAGGAGATACATATCC AGCCTCATCTTGCATCTCTTGCAACCTGCCCTTCCTCAGTGTCTGTTGAAGTAAGTGCAGATGGGGTAAATATGCTACCTTTGTCCACTC CTGTTGTCACAAGTGGCCTCACCTACATAAAAATTCAGCTTGTAAAAGCCGAAGTAGCTTCTGCTGTCTGCCTTAGACTACATCGTCCAC GGGATGCCAGCACATTAGGCCTTTCACAAATTAAATTATTGGGGCTCACTGCTTTTGGTACCACCTCTTCTGCAACAGTTAATAATCCAT TCCTTCCATCTGAAGATCAGGTATCCAAAACAAGTATTGGATGGTTACGGTTATTACATCATTGCCTTACTCACATAAGTGATCTAGAAG GAATGATGGCAAGTGCAGCTGCACCTACTGCTAATCTGCTGCAGACTTGTGCGGCCTTATTGATGTCACCTTACTGTGGAATGCATTCAC CCAACATCGAGGTTGTGCTTGTAAAGATAGGACTGCAGTCTACTAGAATTGGCCTGAAGCTCATAGACATTCTCCTGAGAAATTGTGCAG CATCAGGCAGTGATCCTACAGATTTGAATAGTCCTTTACTTTTTGGAAGACTAAATGGACTCTCTTCTGACTCTACGATAGATATTCTTT ACCAGCTTGGAACAACTCAGGATCCTGGTACAAAAGACAGAATTCAGGCCTTGTTAAAATGGGTTAGTGATTCTGCAAGAGTGGCTGCTA TGAAGAGAAGTGGCAGGATGAACTACATGTGTCCTAACTCCTCAACAGTAGAGTATGGTCTTCTGATGCCATCTCCTTCTCATTTGCACT GTGTAGCAGCCATTCTGTGGCATAGTTATGAGCTGCTTGTAGAATATGACTTACCAGCACTCCTGGACCAAGAGCTCTTTGAGTTACTTT TTAATTGGTCCATGTCTCTTCCCTGCAATATGGTTTTGAAGAAAGCTGTTGACAGTCTACTTTGCTCAATGTGTCACGTACACCCAAACT ATTTTTCTTTGCTCATGGGCTGGATGGGAATTACCCCTCCTCCAGTGCAATGTCATCATAGACTGTCCATGACAGATGATAGCAAAAAGC AGGATCTTAGTTCATCTTTAACAGATGACTCTAAAAATGCACAAGCACCTCTCGCATTAACTGAATCACATTTGGCTACCCTTGCTTCCT CTTCTCAATCTCCTGAAGCTATTAAACAATTACTAGACTCAGGTTTGCCTTCTCTTCTTGTGAGGAGTCTGGCTAGTTTCTGCTTTAGCC ACATTTCTAGCTCAGAAAGCATTGCCCAGTCAATAGATATTTCCCAGGACAAACTCAGGCGCCATCATGTCCCACAACAATGTAATAAGA TGCCTATCACAGCCGACCTAGTTGCTCCTATTCTTAGGTTTTTGACAGAAGTTGGCAATAGCCATATTATGAAAGATTGGCTTGGTGGTT CTGAAGTCAATCCACTATGGACAGCACTTCTGTTTTTATTGTGTCACTCTGGGTCCACTTCTGGAAGCCATAATTTAGGTGCACAACAGA CCAGTGCAAGATCAGCTTCTCTTTCTTCAGCTGCTACAACAGGACTGACTACTCAACAGCGCACAGCAATTGAGAATGCAACTGTTGCGT TCTTTCTACAGTGCATTTCATGCCATCCTAATAATCAAAAGCTGATGGCACAGGTTCTTTGTGAACTATTTCAGACATCTCCTCAAAGAG GGAACCTTCCAACATCTGGGAACATTTCAGGGTTTATACGAAGATTATTTTTACAGTTGATGCTGGAAGATGAGAAAGTGACAATGTTTC TTCAGTCTCCATGTCCACTGTACAAAGGTAGAATTAATGCTACTAGCCACGTCATCCAGCATCCAATGTATGGAGCAGGCCACAAATTCC GTACTCTTCATTTGCCAGTCTCAACAACATTATCAGATGTTCTTGACAGAGTGTCAGATACTCCAAGTATCACAGCTAAATTAATTAGTG AACAAAAAGATGACAAAGAAAAGAAAAACCATGAAGAGAAAGAAAAAGTTAAAGCGGAAAATGGATTTCAAGACAATTACAGTGTTGTTG TTGCCTCTGGGCTGAAGTCTCAATCTAAACGTGCTGTGTCAGCTACACCACCTCGCCCACCATCCAGGAGGGGGAGGACAATACCTGATA AAATAGGAAGTACTTCAGGAGCAGAGGCTGCCAACAAAATAATTACTGTCCCAGTGTTTCACCTGTTTCACAAACTCTTGGCAGGCCAGC CATTGCCAGCTGAAATGACACTTGCCCAGCTTTTAACTCTCCTATATGACCGAAAACTTCCTCAGGGTTACCGCTCAATAGATCTGACTG TTAAATTGGGATCAAGAGTTATAACAGACCCCAGTCTATCAAAAACAGATTCTTATAAAAGACTACACCCTGAAAAAGATCATGGAGACT TACTTGCTAGCTGTCCAGAAGATGAGGCTCTCACTCCAGGTGATGAATGCATGGATGGGATACTGGATGAATCTTTGCTTGAAACCTGTC CAATTCAGTCACCATTACAAGTTTTTGCAGGAATGGGTGGACTGGCTCTTATTGCTGAAAGACTACCCATGCTATATCCAGAAGTAATTC AACAGGTGAGTGCTCCAGTTGTAACATCTACCACTCAGGAAAAGCCGAAGGATAGCGATCAGTTTGAATGGGTGACCATTGAACAGTCAG GGGAGTTAGTTTATGAAGCACCAGAAACTGTTGCGGCTGAACCTCCACCTATCAAGTCAGCAGTACAGACCATGTCTCCCATACCTGCCC ATTCTTTGGCTGCTTTTGGATTATTTCTTCGTCTTCCGGGCTATGCGGAAGTGCTACTGAAAGAGAGAAAACATGCCCAGTGCCTTCTTC GATTGGTATTGGGAGTGACAGATGATGGAGAAGGAAGTCATATTCTTCAATCTCCATCAGCCAATGTGCTTCCAACCCTTCCTTTCCACG TCCTTCGTAGCTTGTTTAGCACTACACCTTTGACAACTGATGATGGTGTACTTCTAAGGCGGATGGCATTGGAAATTGGAGCCTTACACC TCATTCTTGTCTGTCTCTCTGCTTTGAGCCACCATTCCCCACGAGTTCCAAACTCTAGCGTGAATCAAACTGAGCCACAGGTGTCAAGCT CTCATAACCCTACATCAACAGAAGAACAACAGTTATATTGGGCCAAAGGGACTGGCTTTGGAACAGGCTCTACAGCTTCTGGGTGGGATG TGGAACAAGCCTTAACTAAGCAAAGGCTGGAAGAGGAACATGTTACCTGCCTTCTGCAGGTTCTTGCCAGTTACATAAATCCCGTCAGTA GTGCGGTAAATGGAGAAGCTCAGTCATCTCATGAGACTAGAGGGCAGAACAGTAATGCCCTTCCTTCTGTACTTCTCGAGCTTCTCAGTC AGTCCTGCCTCATCCCAGCCATGTCATCTTATCTACGAAATGATTCAGTTCCGAAAGACCCGAAACCCCAGTGGAGACGGGTAGCATGGA GTTACGATTGTACCCTACTGGCCTATGCCGAAAGCACAGGAACTGTGAGGGTGTTTGATCTCATGGGAAGTGAACTCTTTGTCATTTCCC CGGCATCTAGTTTTATAGGTGACTTAAGCTATGCCATTGCTGGGTTGATATTTTTAGAATATAAAGCAAGTGCACAGTGGTCTGCAGAAC TCCTGGTCATCAATTACCGAGGAGAACTTAGAAGTTACCTTGTAAGTGTTGGAACAAATCAGAGCTACCAAGAAAGTCACTGTTTCAGCT TCAGTAGTCATTATCCTCATGGAATCAACACAGCTATTTACCACCCTGGTCACAGACTTTTACTTGTTGGTGGATGTGAAACTGCTGAAG TAGGCATGTCAAAAGCTTCTAGCTGTGGCCTTTCTGCCTGGAGAGTTCTTTCAGGATCACCGTATTATAAGCAGGTTACTAATGGTGGAG ACGGGGTTACTGCAGTACCGAAGACACTGGGATTATTAAGGATGTTAAGTGTCAAGTTTTACAGTCGCCAGGGACAAGAACAGGATGGAA TTTTTAAGATGAGCCTTTCTCCAGATGGGATGCTCCTGGCAGCCATTCACTTCTCAGGGAAACTGAGCATCTGGGCGATTCCATCTCTGA AGCAACAAGGGGAATGGGGTCAAAATGAGCAGCCAGGCTATGATGACCTTAATCCTGATTGGAGGCTCTCTACTGAGAAGAGAAAAAAAA TCAAAGATAAAGAGTCCTTTTACCCACTGATAGATGTCAATTGGTGGGCAGACAGTGCAGTGACTTTAGCTCGATGCTCTGGTGCTTTAA CTGTTTCATCTGTGAAAACTTTGAAGAATTTACTGGGAAAATCCTGTGAATGGTTTGAACCATCACCTCAAGTCACTGCTACCCATGATG GGGGATTTTTAAGTTTGGAGTGTGAGATTAAACTTGCCCCCAAACGATCTCGTTTGGAGACTAGAGCTGGAGAAGAAGATGAAGGAGAAG AGGATTCTGATTCTGATTATGAAATATCTGCCAAGGCTCGCTACTTTGGTTATATAAAACAGGGCCTTTACTTGGTGACTGAAATGGAGC GATTTGCACCACCACGGAAACGCCCACGAACCATTACTAAAAACTACCGCCTTGTGAGTTTGCGCTCCACGACACCAGAGGAACTTTATC AGAGGAAGATTGAAAGTGAAGAGTATGAGGAAGCCTTGTCCTTGGCTCATACCTACGGCCTGGATACTGACCTTGTATATCAGAGGCAGT GGAGGAAGTCAGCGGTCAACGTTGCTTCAATTCAGAATTATTTGAGTAAAATAAAGAAGCGATCCTGGGTTCTCCATGAGTGTTTGGAAA GAGTTCCTGAAAATGTGGATGCTGCAAAAGAACTGCTTCAGTATGGATTAAAAGGCACAGACCTGGAGGCTCTTTTAGCAATAGGGAAAG GAGCAGATGATGGCAGATTTACATTACCTGGTGAAATAGACATTGACAGTATCTCCTATGAAGAGCTTTCACCACCTGATGAAGAGCCTG CCAAGAATAAAAAGGAAAAGGAGCTCAAGAAGAGACAAGAACTACTGAAATTAGTGAACTTTTCCAAGTTGACACTGGAACAAAAGGAAC TTTGCCGTTGTAGACGGAAGTTATTAACCTACTTAGATCGACTTGCAACATATGAGGAAATCCTAGGAGTGCCTCATGCATCTGAACAGA GATATGATGCTGAATTCTTTAAGAAATTCAGAAATCAGAATATTGTTCTCTCAGCAAGAACTTATGCTCAGGAAAGTAATGTACAAGCCC TGGAAATTCTGTTTACTTACCATGGTTCCGACCTGCTTCCTCATCGCCTTGCAATTCTGTCCAACTTTCCAGAGACCACTTCTCCACATG AATATTCTGTTTTGCTGCCCGAAGCTTGTTTTAACGGTGACTCCCTGATGATCATTCCTTGGCATGAACATAAACACCGAGCTAAAGATT GGTGCGAGGAGTTGGCTTGCAGAATGGTTGTTGAGCCGAATCTCCAAGATGAAAGTGAATTCTTGTATGCTGCACAGCCTGAGTTACTAA GGTTCAGGATGACCCAGCTTACGGTGGAGAAGGTTATGGACTGGTATCAGACCAGAGCAGAGGAAATAGAGCATTATGCTCGGCAGGTGG ACTGTGCATTGTCACTTATTCGACTTGGGATGGAGCGGAATATTCCTGGTTTGCTGGTTCTCTGTGACAATTTGGTTACTCTGGAAACAT TGGTTTATGAAGCCAGGTGTGATGTAACTCTAACCCTGAAAGAACTCCAGCAGATGAAAGACATTGAAAAACTAAGATTACTGATGAATA GTTGTTCTGAGGATAAATATGTGACAAGTGCCTACCAGTGGATGGTTCCCTTTCTTCATCGTTGTGAGAAACAGTCGCCTGGTGTGGCTA ATGAGCTATTAAAAGAATATTTAGTAACTTTAGCTAAAGGGGACTTAAAATTTCCCCTGAAGATATTTCAGCATTCCAAACCAGATCTGC AGCAAAAAATTATTCCTGATCAGGACCAACTGATGGCAATAGCACTAGAGTGCATCTATACCTGTGAACGAAATGATCAACTCTGTCTTT GCTATGACCTACTAGAATGTCTGCCAGAAAGAGGATATGGTGATAAGACAGAGGCAACCACAAAGCTTCATGACATGGTAGACCAACTGG AACAAATTCTCAGTGTGTCAGAGCTTTTGGAAAAACATGGACTCGAGAAACCAATTTCATTTGTTAAAAACACTCAATCTAGCTCAGAAG AGGCACGCAAGCTGATGGTTAGATTGACGAGGCACACTGGCCGGAAGCAGCCTCCTGTCAGTGAGTCTCATTGGAGAACGTTGCTGCAAG ACATGTTAACTATGCAGCAGAATGTATACACATGTCTAGATTCTGATGCCTGCTATGAGATATTTACAGAAAGCCTTCTGTGCTCTAGTC GCCTTGAAAACATCCACCTGGCTGGACAGATGATGCACTGCAGTGCTTGTTCAGAAAATCCTCCAGCTGGTATAGCCCATAAAGGGAAAC CCCACTACAGGGTCAGCTACGAAAAGAGTATTGACTTGGTTTTGGCTGCCAGCAGAGAGTACTTCAATTCTTCTACCAACCTCACTGATA GCTGCATGGATCTAGCCAGGTGCTGCTTACAACTGATAACAGACAGACCCCCTGCCATTCAAGAGGAGCTAGATCTTATCCAAGCCGTTG GATGTCTTGAAGAATTTGGGGTAAAGATCCTGCCTTTGCAAGTGCGATTGTGCCCTGATCGGATCAGTCTCATCAAGGAGTGTATTTCCC AGTCCCCCACATGCTATAAACAATCCACCAAGCTTCTGGGCCTTGCTGAGCTGCTGAGGGTTGCAGGTGAGAACCCAGAAGAAAGGCGGG GACAGGTTCTAATCCTTTTAGTGGAGCAGGCACTTCGCTTCCATGACTACAAAGCAGCCAGTATGCATTGTCAGGAGCTGATGGCCACAG GTTATCCTAAAAGTTGGGATGTTTGTAGCCAGTTAGGACAATCAGAAGGTTACCAGGACTTGGCCACTCGTCAAGAGCTCATGGCTTTTG CTTTGACACATTGCCCTCCTAGCAGCATTGAACTTCTTTTGGCAGCTAGCAGCTCTCTGCAGACAGAAATTCTTTATCAAAGAGTGAATT TCCAGATCCATCATGAAGGAGGGGAAAATATCAGTGCTTCACCATTAACTAGTAAAGCAGTACAAGAGGATGAAGTAGGTGTTCCAGGTA GCAATTCAGCTGACCTATTGCGCTGGACCACTGCTACCACCATGAAAGTCCTTTCCAACACCACAACCACCACCAAAGCGGTGCTGCAGG CCGTCAGTGATGGGCAGTGGTGGAAGAAGTCTTTAACTTACCTTCGACCCCTTCAGGGGCAAAAATGTGGTGGTGCATATCAAATCGGAA CTACAGCCAATGAAGATCTAGAGAAACAAGGGTGTCATCCTTTTTATGAATCTGTCATCTCAAATCCTTTTGTCGCTGAGTCTGAAGGGA CCTATGACACCTATCAGCATGTTCCAGTGGAAAGCTTTGCAGAAGTATTGCTGAGAACTGGAAAATTGGCAGAGGCTAAAAATAAAGGAG AAGTATTTCCAACAACTGAAGTTCTCTTGCAACTAGCAAGTGAAGCCTTGCCAAATGACATGACCTTGGCTCTTGCTTACCTTCTTGCCT TACCACAAGTGTTAGATGCTAACCGGTGCTTTGAAAAGCAGTCCCCCTCTGCATTATCTCTCCAGCTGGCAGCGTATTACTATAGCCTCC AGATCTATGCCCGATTGGCCCCATGTTTCAGGGACAAGTGCCATCCTCTTTACAGGGCTGATCCCAAAGAACTAATCAAGATGGTCACCA GGCATGTGACTCGACATGAGCACGAAGCCTGGCCTGAAGACCTTATTTCACTGACCAAGCAGTTACACTGCTACAATGAACGTCTCCTGG ATTTCACTCAGGCGCAGATCCTTCAGGGCCTTCGGAAGGGTGTGGACGTGCAGCGGTTTACTGCAGATGACCAGTATAAAAGGGAAACTA TCCTTGGTCTGGCAGAAACTCTAGAGGAAAGCGTCTACAGCATTGCTATTTCTCTGGCACAACGTTACAGTGTCTCCCGCTGGGAAGTTT TTATGACCCATTTGGAGTTCCTCTTCACGGACAGTGGTTTGTCCACACTAGAAATTGAAAATAGAGCCCAAGACCTTCATCTCTTTGAGA CTTTGAAGACTGATCCAGAAGCCTTTCACCAGCACATGGTCAAGTATATTTACCCTACTATTGGTGGCTTTGATCACGAAAGGCTGCAGT ATTATTTCACTCTTCTGGAAAACTGTGGCTGTGCAGATTTGGGGAACTGTGCCATTAAACCAGAAACCCACATTCGACTGCTGAAGAAGT TTAAGGTTGTTGCATCAGGTCTTAATTACAAAAAGCTGACAGATGAAAACATGAGTCCTCTTGAAGCATTGGAGCCAGTTCTTTCAAGTC AAAATATCTTGTCTATTTCCAAACTTGTTCCCAAAATCCCTGAAAAGGATGGACAGATGCTTTCCCCAAGCTCTCTGTACACCATCTGGT TACAGAAGTTGTTCTGGACTGGAGACCCTCATCTCATTAAACAAGTCCCAGGCTCTTCACCGGAGTGGCTTCATGCCTATGATGTCTGCA TGAAGTACTTTGATCGTCTCCACCCAGGTGACCTCATCACTGTGGTAGATGCAGTTACATTTTCTCCAAAAGCTGTGACCAAGCTGTCTG TGGAAGCCCGTAAAGAGATGACTAGAAAGGCTATTAAGACAGTCAAACATTTTATTGAGAAGCCAAGGAAAAGAAACTCAGAAGACGAAG CTCAAGAAGCTAAGGATTCTAAAGTTACCTATGCAGATACTTTGAATCATCTGGAGAAATCACTTGCCCACCTGGAAACCCTGAGCCACA GCTTCATCCTTTCTCTGAAGAATAGTGAGCAGGAAACACTGCAAAAATACAGTCACCTCTATGATCTGTCCCGATCAGAAAAAGAGAAAC TTCATGATGAAGCTGTGGCTATTTGTTTAGATGGTCAGCCTCTAGCAATGATTCAGCAGCTGCTAGAGGTGGCAGTTGGCCCTCTTGACA TCTCACCCAAGGATATAGTGCAGAGTGCAATCATGAAAATAATTTCTGCATTGAGTGGTGGCAGTGCTGACCTTGGTGGGCCAAGGGACC CACTGAAGGTCCTGGAAGGTGTTGTTGCAGCAGTCCACGCCAGTGTGGACAAGGGTGAGGAGCTGGTTTCACCTGAGGACCTGCTGGAGT GGCTGCGGCCTTTCTGTGCTGATGACGCCTGGCCGGTGCGGCCCCGCATTCACGTGCTGCAGATTTTGGGGCAATCATTTCACCTGACTG AGGAGGACAGCAAGCTCCTCGTGTTCTTTAGAACTGAAGCCATTCTCAAAGCCTCCTGGCCCCAGAGACAGGTAGACATAGCTGACATTG AGAATGAAGAGAACCGCTACTGTCTATTCATGGAACTCCTGGAATCTAGTCACCACGAGGCTGAATTTCAGCACTTGGTTTTACTTTTGC AAGCTTGGCCACCTATGAAAAGTGAATATGTCATAACCAATAATCCATGGGTGAGACTAGCTACAGTGATGCTAACCAGATGTACGATGG AGAACAAGGAAGGATTGGGGAATGAAGTTTTGAAAATGTGTCGCTCTTTGTATAACACCAAGCAGATGCTGCCTGCAGAGGGTGTGAAGG AGCTGTGTCTGCTGCTGCTTAACCAGTCCCTCCTGCTTCCATCTCTGAAACTTCTCCTCGAGAGCCGAGATGAGCATCTGCACGAGATGG CACTGGAGCAAATCACGGCAGTCACTACGGTGAATGATTCCAATTGTGACCAAGAACTTCTTTCCCTGCTCCTGGATGCCAAGCTGCTGG TGAAGTGTGTCTCCACTCCCTTCTATCCACGTATTGTTGACCACCTCTTGGCTAGCCTCCAGCAAGGGCGCTGGGATGCAGAGGAGCTGG GCAGACACCTGCGGGAGGCCGGCCATGAAGCCGAAGCCGGGTCTCTCCTTCTGGCCGTGAGGGGGACTCACCAGGCCTTCAGAACCTTCA GTACAGCCCTCCGCGCAGCACAGCACTGGGTGTGAGGGCCACCTGTGGCCCTGCTCCTTAGCAGAAAAAGCATCTGGAGTTGAATGCTGT >9762_9762_1_BIRC6-NBAS_BIRC6_chr2_32774548_ENST00000421745_NBAS_chr2_15679480_ENST00000281513_length(amino acids)=6626AA_BP=4381 MVTGGGAAPPGTVTEPLPSVIVLSAGRKMAAAAAAASGPGCSSAAGAGAAGVSEWLVLRDGCMHCDADGLHSLSYHPALNAILAVTSRGT IKVIDGTSGATLQASALSAKPGGQVKCQYISAVDKVIFVDDYAVGCRKDLNGILLLDTALQTPVSKQDDVVQLELPVTEAQQLLSACLEK VDISSTEGYDLFITQLKDGLKNTSHETAANHKVAKWATVTFHLPHHVLKSIASAIVNELKKINQNVAALPVASSVMDRLSYLLPSARPEL GVGPGRSVDRSLMYSEANRRETFTSWPHVGYRWAQPDPMAQAGFYHQPASSGDDRAMCFTCSVCLVCWEPTDEPWSEHERHSPNCPFVKG EHTQNVPLSVTLATSPAQFPCTDGTDRISCFGSGSCPHFLAAATKRGKICIWDVSKLMKVHLKFEINAYDPAIVQQLILSGDPSSGVDSR RPTLAWLEDSSSCSDIPKLEGDSDDLLEDSDSEEHSRSDSVTGHTSQKEAMEVSLDITALSILQQPEKLQWEIVANVLEDTVKDLEELGA NPCLTNSKSEKTKEKHQEQHNIPFPCLLAGGLLTYKSPATSPISSNSHRSLDGLSRTQGESISEQGSTDNESCTNSELNSPLVRRTLPVL LLYSIKESDEKAGKIFSQMNNIMSKSLHDDGFTVPQIIEMELDSQEQLLLQDPPVTYIQQFADAAANLTSPDSEKWNSVFPKPGTLVQCL RLPKFAEEENLCIDSITPCADGIHLLVGLRTCPVESLSAINQVEALNNLNKLNSALCNRRKGELESNLAVVNGANISVIQHESPADVQTP LIIQPEQRNVSGGYLVLYKMNYATRIVTLEEEPIKIQHIKDPQDTITSLILLPPDILDNREDDCEEPIEDMQLTSKNGFEREKTSDISTL GHLVITTQGGYVKILDLSNFEILAKVEPPKKEGTEEQDTFVSVIYCSGTDRLCACTKGGELHFLQIGGTCDDIDEADILVDGSLSKGIEP SSEGSKPLSNPSSPGISGVDLLVDQPFTLEILTSLVELTRFETLTPRFSATVPPCWVEVQQEQQQRRHPQHLHQQHHGDAAQHTRTWKLQ TDSNSWDEHVFELVLPKACMVGHVDFKFVLNSNITNIPQIQVTLLKNKAPGLGKVNALNIEVEQNGKPSLVDLNEEMQHMDVEESQCLRL CPFLEDHKEDILCGPVWLASGLDLSGHAGMLTLTSPKLVKGMAGGKYRSFLIHVKAVNERGTEEICNGGMRPVVRLPSLKHQSNKGYSLA SLLAKVAAGKEKSSNVKNENTSGTRKSENLRGCDLLQEVSVTIRRFKKTSISKERVQRCAMLQFSEFHEKLVNTLCRKTDDGQITEHAQS LVLDTLCWLAGVHSNGPGSSKEGNENLLSKTRKFLSDIVRVCFFEAGRSIAHKCARFLALCISNGKCDPCQPAFGPVLLKALLDNMSFLP AATTGGSVYWYFVLLNYVKDEDLAGCSTACASLLTAVSRQLQDRLTPMEALLQTRYGLYSSPFDPVLFDLEMSGSSCKNVYNSSIGVQSD EIDLSDVLSGNGKVSSCTAAEGSFTSLTGLLEVEPLHFTCVSTSDGTRIERDDAMSSFGVTPAVGGLSSGTVGEASTALSSAAQVALQSL SHAMASAEQQLQVLQEKQQQLLKLQQQKAKLEAKLHQTTAAAAAAASAVGPVHNSVPSNPVAAPGFFIHPSDVIPPTPKTTPLFMTPPLT PPNEAVSVVINAELAQLFPGSVIDPPAVNLAAHNKNSNKSRMNPLGSGLALAISHASHFLQPPPHQSIIIERMHSGARRFVTLDFGRPIL LTDVLIPTCGDLASLSIDIWTLGEEVDGRRLVVATDISTHSLILHDLIPPPVCRFMKITVIGRYGSTNARAKIPLGFYYGHTYILPWESE LKLMHDPLKGEGESANQPEIDQHLAMMVALQEDIQCRYNLACHRLETLLQSIDLPPLNSANNAQYFLRKPDKAVEEDSRVFSAYQDCIQL QLQLNLAHNAVQRLKVALGASRKMLSETSNPEDLIQTSSTEQLRTIIRYLLDTLLSLLHASNGHSVPAVLQSTFHAQACEELFKHLCISG TPKIRLHTGLLLVQLCGGERWWGQFLSNVLQELYNSEQLLIFPQDRVFMLLSCIGQRSLSNSGVLESLLNLLDNLLSPLQPQLPMHRRTE GVLDIPMISWVVMLVSRLLDYVATVEDEAAAAKKPLNGNQWSFINNNLHTQSLNRSSKGSSSLDRLYSRKIRKQLVHHKQQLNLLKAKQK ALVEQMEKEKIQSNKGSSYKLLVEQAKLKQATSKHFKDLIRLRRTAEWSRSNLDTEVTTAKESPEIEPLPFTLAHERCISVVQKLVLFLL SMDFTCHADLLLFVCKVLARIANATRPTIHLCEIVNEPQLERLLLLLVGTDFNRGDISWGGAWAQYSLTCMLQDILAGELLAPVAAEAME EGTVGDDVGATAGDSDDSLQQSSVQLLETIDEPLTHDITGAPPLSSLEKDKEIDLELLQDLMEVDIDPLDIDLEKDPLAAKVFKPISSTW YDYWGADYGTYNYNPYIGGLGIPVAKPPANTEKNGSQTVSVSVSQALDARLEVGLEQQAELMLKMMSTLEADSILQALTNTSPTLSQSPT GTDDSLLGGLQAANQTSQLIIQLSSVPMLNVCFNKLFSMLQVHHVQLESLLQLWLTLSLNSSSTGNKENGADIFLYNANRIPVISLNQAS ITSFLTVLAWYPNTLLRTWCLVLHSLTLMTNMQLNSGSSSAIGTQESTAHLLVSDPNLIHVLVKFLSGTSPHGTNQHSPQVGPTATQAMQ EFLTRLQVHLSSTCPQIFSEFLLKLIHILSTERGAFQTGQGPLDAQVKLLEFTLEQNFEVVSVSTISAVIESVTFLVHHYITCSDKVMSR SGSDSSVGARACFGGLFANLIRPGDAKAVCGEMTRDQLMFDLLKLVNILVQLPLSGNREYSARVSVTTNTTDSVSDEEKVSGGKDGNGSS TSVQGSPAYVADLVLANQQIMSQILSALGLCNSSAMAMIIGASGLHLTKHENFHGGLDAISVGDGLFTILTTLSKKASTVHMMLQPILTY MACGYMGRQGSLATCQLSEPLLWFILRVLDTSDALKAFHDMGGVQLICNNMVTSTRAIVNTARSMVSTIMKFLDSGPNKAVDSTLKTRIL ASEPDNAEGIHNFAPLGTITSSSPTAQPAEVLLQATPPHRRARSAAWSYIFLPEEAWCDLTIHLPAAVLLKEIHIQPHLASLATCPSSVS VEVSADGVNMLPLSTPVVTSGLTYIKIQLVKAEVASAVCLRLHRPRDASTLGLSQIKLLGLTAFGTTSSATVNNPFLPSEDQVSKTSIGW LRLLHHCLTHISDLEGMMASAAAPTANLLQTCAALLMSPYCGMHSPNIEVVLVKIGLQSTRIGLKLIDILLRNCAASGSDPTDLNSPLLF GRLNGLSSDSTIDILYQLGTTQDPGTKDRIQALLKWVSDSARVAAMKRSGRMNYMCPNSSTVEYGLLMPSPSHLHCVAAILWHSYELLVE YDLPALLDQELFELLFNWSMSLPCNMVLKKAVDSLLCSMCHVHPNYFSLLMGWMGITPPPVQCHHRLSMTDDSKKQDLSSSLTDDSKNAQ APLALTESHLATLASSSQSPEAIKQLLDSGLPSLLVRSLASFCFSHISSSESIAQSIDISQDKLRRHHVPQQCNKMPITADLVAPILRFL TEVGNSHIMKDWLGGSEVNPLWTALLFLLCHSGSTSGSHNLGAQQTSARSASLSSAATTGLTTQQRTAIENATVAFFLQCISCHPNNQKL MAQVLCELFQTSPQRGNLPTSGNISGFIRRLFLQLMLEDEKVTMFLQSPCPLYKGRINATSHVIQHPMYGAGHKFRTLHLPVSTTLSDVL DRVSDTPSITAKLISEQKDDKEKKNHEEKEKVKAENGFQDNYSVVVASGLKSQSKRAVSATPPRPPSRRGRTIPDKIGSTSGAEAANKII TVPVFHLFHKLLAGQPLPAEMTLAQLLTLLYDRKLPQGYRSIDLTVKLGSRVITDPSLSKTDSYKRLHPEKDHGDLLASCPEDEALTPGD ECMDGILDESLLETCPIQSPLQVFAGMGGLALIAERLPMLYPEVIQQVSAPVVTSTTQEKPKDSDQFEWVTIEQSGELVYEAPETVAAEP PPIKSAVQTMSPIPAHSLAAFGLFLRLPGYAEVLLKERKHAQCLLRLVLGVTDDGEGSHILQSPSANVLPTLPFHVLRSLFSTTPLTTDD GVLLRRMALEIGALHLILVCLSALSHHSPRVPNSSVNQTEPQVSSSHNPTSTEEQQLYWAKGTGFGTGSTASGWDVEQALTKQRLEEEHV TCLLQVLASYINPVSSAVNGEAQSSHETRGQNSNALPSVLLELLSQSCLIPAMSSYLRNDSVPKDPKPQWRRVAWSYDCTLLAYAESTGT VRVFDLMGSELFVISPASSFIGDLSYAIAGLIFLEYKASAQWSAELLVINYRGELRSYLVSVGTNQSYQESHCFSFSSHYPHGINTAIYH PGHRLLLVGGCETAEVGMSKASSCGLSAWRVLSGSPYYKQVTNGGDGVTAVPKTLGLLRMLSVKFYSRQGQEQDGIFKMSLSPDGMLLAA IHFSGKLSIWAIPSLKQQGEWGQNEQPGYDDLNPDWRLSTEKRKKIKDKESFYPLIDVNWWADSAVTLARCSGALTVSSVKTLKNLLGKS CEWFEPSPQVTATHDGGFLSLECEIKLAPKRSRLETRAGEEDEGEEDSDSDYEISAKARYFGYIKQGLYLVTEMERFAPPRKRPRTITKN YRLVSLRSTTPEELYQRKIESEEYEEALSLAHTYGLDTDLVYQRQWRKSAVNVASIQNYLSKIKKRSWVLHECLERVPENVDAAKELLQY GLKGTDLEALLAIGKGADDGRFTLPGEIDIDSISYEELSPPDEEPAKNKKEKELKKRQELLKLVNFSKLTLEQKELCRCRRKLLTYLDRL ATYEEILGVPHASEQRYDAEFFKKFRNQNIVLSARTYAQESNVQALEILFTYHGSDLLPHRLAILSNFPETTSPHEYSVLLPEACFNGDS LMIIPWHEHKHRAKDWCEELACRMVVEPNLQDESEFLYAAQPELLRFRMTQLTVEKVMDWYQTRAEEIEHYARQVDCALSLIRLGMERNI PGLLVLCDNLVTLETLVYEARCDVTLTLKELQQMKDIEKLRLLMNSCSEDKYVTSAYQWMVPFLHRCEKQSPGVANELLKEYLVTLAKGD LKFPLKIFQHSKPDLQQKIIPDQDQLMAIALECIYTCERNDQLCLCYDLLECLPERGYGDKTEATTKLHDMVDQLEQILSVSELLEKHGL EKPISFVKNTQSSSEEARKLMVRLTRHTGRKQPPVSESHWRTLLQDMLTMQQNVYTCLDSDACYEIFTESLLCSSRLENIHLAGQMMHCS ACSENPPAGIAHKGKPHYRVSYEKSIDLVLAASREYFNSSTNLTDSCMDLARCCLQLITDRPPAIQEELDLIQAVGCLEEFGVKILPLQV RLCPDRISLIKECISQSPTCYKQSTKLLGLAELLRVAGENPEERRGQVLILLVEQALRFHDYKAASMHCQELMATGYPKSWDVCSQLGQS EGYQDLATRQELMAFALTHCPPSSIELLLAASSSLQTEILYQRVNFQIHHEGGENISASPLTSKAVQEDEVGVPGSNSADLLRWTTATTM KVLSNTTTTTKAVLQAVSDGQWWKKSLTYLRPLQGQKCGGAYQIGTTANEDLEKQGCHPFYESVISNPFVAESEGTYDTYQHVPVESFAE VLLRTGKLAEAKNKGEVFPTTEVLLQLASEALPNDMTLALAYLLALPQVLDANRCFEKQSPSALSLQLAAYYYSLQIYARLAPCFRDKCH PLYRADPKELIKMVTRHVTRHEHEAWPEDLISLTKQLHCYNERLLDFTQAQILQGLRKGVDVQRFTADDQYKRETILGLAETLEESVYSI AISLAQRYSVSRWEVFMTHLEFLFTDSGLSTLEIENRAQDLHLFETLKTDPEAFHQHMVKYIYPTIGGFDHERLQYYFTLLENCGCADLG NCAIKPETHIRLLKKFKVVASGLNYKKLTDENMSPLEALEPVLSSQNILSISKLVPKIPEKDGQMLSPSSLYTIWLQKLFWTGDPHLIKQ VPGSSPEWLHAYDVCMKYFDRLHPGDLITVVDAVTFSPKAVTKLSVEARKEMTRKAIKTVKHFIEKPRKRNSEDEAQEAKDSKVTYADTL NHLEKSLAHLETLSHSFILSLKNSEQETLQKYSHLYDLSRSEKEKLHDEAVAICLDGQPLAMIQQLLEVAVGPLDISPKDIVQSAIMKII SALSGGSADLGGPRDPLKVLEGVVAAVHASVDKGEELVSPEDLLEWLRPFCADDAWPVRPRIHVLQILGQSFHLTEEDSKLLVFFRTEAI LKASWPQRQVDIADIENEENRYCLFMELLESSHHEAEFQHLVLLLQAWPPMKSEYVITNNPWVRLATVMLTRCTMENKEGLGNEVLKMCR SLYNTKQMLPAEGVKELCLLLLNQSLLLPSLKLLLESRDEHLHEMALEQITAVTTVNDSNCDQELLSLLLDAKLLVKCVSTPFYPRIVDH -------------------------------------------------------------- >9762_9762_2_BIRC6-NBAS_BIRC6_chr2_32774548_ENST00000421745_NBAS_chr2_15679480_ENST00000441750_length(transcript)=19795nt_BP=13278nt TCCCTGCTTCTCCCCCTCTCCCGTCAGCCTCCCTCCGAGTTTGGCCCCTCCGGCCGGGCGATCGACGTTCCGCGTGCGTGCGGGCGCCTG ACTTCACTTCCGGCTAACGCGCTCGGCTTGCCCCCTGGCCCCGGATGGTGACTGGTGGTGGTGCTGCACCTCCCGGGACTGTCACTGAGC CGCTTCCCAGTGTGATTGTGCTGAGCGCAGGCCGGAAGATGGCGGCTGCGGCTGCGGCGGCCTCGGGCCCCGGCTGCTCCTCGGCGGCGG GGGCGGGGGCGGCCGGGGTCTCAGAGTGGCTGGTGCTGCGGGACGGCTGCATGCACTGCGACGCCGACGGGCTGCACAGCCTGTCCTACC ACCCTGCGCTCAACGCCATCCTGGCCGTCACTAGCCGCGGGACCATCAAAGTCATCGACGGCACCTCGGGGGCCACACTGCAGGCCTCCG CGCTCAGTGCTAAACCAGGTGGACAGGTGAAATGTCAGTATATCTCTGCTGTGGATAAAGTTATATTTGTGGATGATTATGCAGTAGGGT GTAGGAAGGACCTTAATGGAATCTTGTTGTTAGACACTGCTCTGCAAACTCCAGTTTCAAAGCAGGATGATGTGGTTCAGCTTGAATTAC CCGTTACAGAGGCACAGCAGCTCTTATCAGCATGTTTAGAAAAGGTAGATATTTCTAGTACAGAGGGTTATGATTTGTTCATCACACAGC TCAAAGATGGTTTAAAAAATACATCTCATGAGACTGCAGCAAACCACAAAGTTGCTAAGTGGGCCACAGTTACATTTCATCTTCCTCATC ATGTGTTGAAGTCCATTGCCAGTGCCATTGTAAATGAACTCAAGAAAATAAATCAAAATGTTGCTGCCTTACCTGTGGCGTCCTCAGTGA TGGACAGATTGTCTTACCTCTTACCTAGTGCACGTCCAGAACTCGGAGTGGGGCCAGGCCGTTCTGTAGACAGATCACTGATGTATAGTG AAGCTAACAGACGGGAGACATTTACCTCATGGCCTCATGTAGGCTATAGGTGGGCACAACCAGATCCCATGGCTCAAGCTGGATTTTATC ATCAGCCTGCCTCATCTGGAGATGATAGAGCCATGTGTTTTACTTGTAGTGTATGCCTCGTTTGTTGGGAACCTACTGATGAACCTTGGT CTGAACACGAAAGACATTCCCCAAACTGCCCATTTGTGAAAGGTGAGCACACACAGAATGTGCCATTGTCAGTCACTCTTGCAACAAGTC CTGCACAGTTTCCTTGTACGGATGGAACTGACAGAATATCTTGCTTTGGGTCGGGGAGCTGCCCTCATTTTCTAGCTGCTGCAACTAAAC GAGGAAAGATCTGCATATGGGATGTTTCCAAACTTATGAAGGTGCACTTAAAGTTTGAAATTAATGCCTATGATCCAGCAATTGTACAAC AGCTTATTCTATCAGGAGACCCAAGCTCAGGAGTTGATTCAAGGAGACCAACTTTGGCGTGGCTGGAGGACTCCTCTAGTTGCTCAGATA TACCAAAATTGGAAGGAGATAGTGATGATTTACTGGAGGATTCAGACAGTGAAGAGCATTCCAGATCAGATTCTGTGACAGGGCATACAT CACAGAAGGAAGCCATGGAAGTAAGCCTTGATATAACAGCACTCAGCATTCTCCAACAGCCAGAAAAACTTCAGTGGGAGATTGTTGCAA ATGTGCTTGAAGATACTGTTAAGGATCTTGAAGAACTTGGGGCAAATCCTTGTTTAACAAACTCTAAGAGTGAAAAGACAAAGGAAAAGC ACCAGGAGCAACACAACATTCCTTTTCCATGTTTATTAGCTGGAGGTTTATTAACATATAAATCTCCTGCTACCTCACCCATTAGTAGTA ATTCTCACAGGTCACTGGATGGTTTAAGCAGAACTCAGGGTGAAAGTATATCAGAACAAGGGTCAACTGACAATGAATCCTGCACTAATT CAGAACTAAATTCTCCTCTGGTAAGGAGGACTTTACCGGTTTTGCTTCTTTATAGCATCAAGGAATCTGATGAGAAAGCAGGAAAGATCT TTTCACAGATGAACAATATTATGAGTAAAAGTTTGCATGATGATGGTTTTACTGTTCCACAGATTATTGAAATGGAGCTGGATAGTCAGG AGCAGTTGTTATTGCAGGATCCTCCTGTGACTTACATTCAGCAATTTGCAGATGCAGCAGCCAACCTTACCTCTCCGGATTCTGAGAAGT GGAACTCTGTGTTTCCCAAGCCTGGGACTTTGGTTCAGTGCTTGAGGCTGCCAAAGTTTGCAGAGGAGGAGAATCTTTGTATAGACTCAA TAACTCCTTGTGCTGACGGAATTCATTTGTTGGTAGGACTGCGGACATGCCCTGTTGAATCCTTGAGTGCAATAAATCAAGTAGAGGCCT TGAATAATTTAAATAAATTAAACTCTGCACTATGTAATAGACGGAAAGGTGAGCTGGAATCAAATCTTGCTGTAGTGAATGGTGCAAATA TTAGTGTAATCCAACATGAATCACCAGCAGATGTACAGACTCCTTTAATAATTCAGCCTGAGCAGAGGAATGTTAGTGGTGGATATTTAG TGCTTTATAAAATGAATTATGCCACTCGGATAGTGACTTTAGAAGAGGAGCCAATAAAAATACAACATATCAAAGATCCCCAGGACACAA TTACCTCGCTCATTTTGCTTCCACCCGATATATTGGATAATCGAGAGGATGACTGTGAGGAACCTATTGAGGACATGCAGTTAACCTCAA AGAATGGTTTTGAGAGAGAAAAAACGTCTGACATTTCTACTCTTGGACACCTGGTAATAACCACTCAGGGAGGATATGTAAAAATACTAG ATCTTTCAAACTTTGAAATTTTGGCCAAAGTGGAGCCTCCCAAAAAGGAGGGCACTGAGGAACAGGACACATTTGTTTCTGTGATTTACT GTTCTGGCACAGACAGGCTGTGTGCATGCACCAAAGGTGGTGAGCTTCATTTTCTCCAAATTGGAGGAACCTGTGATGATATTGATGAAG CTGATATACTAGTGGATGGATCTCTTTCTAAAGGAATAGAACCATCTTCAGAAGGTTCCAAACCTTTATCAAATCCTTCAAGTCCTGGCA TTTCAGGAGTTGATTTATTGGTGGACCAGCCATTCACCCTTGAAATCTTGACATCCCTAGTGGAGCTAACCCGCTTTGAGACTTTGACTC CAAGGTTTTCAGCGACTGTTCCTCCATGCTGGGTAGAAGTTCAACAAGAACAGCAGCAAAGGAGGCATCCTCAACATTTGCATCAGCAAC ACCATGGTGATGCTGCTCAGCATACTCGAACTTGGAAACTACAGACCGACAGCAACAGCTGGGATGAACATGTATTTGAATTAGTACTAC CTAAAGCTTGTATGGTTGGACATGTGGACTTCAAATTCGTTTTGAACTCAAACATCACCAATATTCCACAGATACAAGTGACACTGCTGA AAAATAAAGCTCCAGGATTAGGGAAAGTCAATGCTCTTAACATTGAAGTGGAACAAAATGGGAAACCGTCCCTGGTTGATTTGAATGAAG AAATGCAGCACATGGATGTAGAGGAATCACAGTGTCTTAGATTATGTCCATTTTTGGAGGATCATAAAGAAGACATTCTATGTGGGCCAG TATGGCTTGCTAGTGGCCTTGATCTATCAGGGCATGCTGGAATGTTGACGTTAACAAGCCCCAAACTTGTTAAAGGTATGGCAGGAGGAA AATATCGTTCGTTTTTAATCCATGTCAAGGCAGTGAATGAAAGAGGAACAGAAGAGATTTGTAATGGTGGTATGCGTCCTGTAGTAAGGC TTCCATCCCTAAAACACCAGAGTAACAAGGGTTATTCACTTGCTTCACTTTTGGCTAAAGTTGCAGCAGGCAAGGAAAAATCATCTAATG TTAAGAATGAAAATACAAGTGGCACCCGTAAATCTGAAAACCTCCGGGGCTGTGATTTACTTCAAGAGGTCTCAGTCACCATTCGAAGAT TTAAGAAAACCTCAATTTCTAAGGAAAGAGTGCAACGATGTGCCATGTTACAGTTTTCAGAATTTCATGAGAAGCTTGTTAATACTCTTT GCAGAAAAACAGATGATGGCCAGATCACAGAACATGCCCAGAGCCTTGTGTTGGATACTCTCTGTTGGTTAGCTGGAGTTCATTCAAATG GACCCGGAAGCTCAAAGGAAGGAAATGAGAACCTACTTTCAAAAACACGAAAATTTCTGTCAGACATCGTACGTGTTTGCTTCTTTGAGG CAGGACGAAGTATAGCCCATAAGTGTGCCCGATTTCTAGCCTTGTGCATTAGTAATGGCAAATGTGACCCATGTCAACCAGCATTTGGAC CTGTTCTGTTGAAGGCTTTACTTGATAATATGTCATTTTTACCTGCAGCAACAACTGGTGGTTCTGTCTATTGGTATTTTGTCTTACTGA ATTATGTGAAAGATGAAGATCTGGCTGGATGCAGTACAGCTTGTGCATCTTTGCTTACTGCAGTGTCCAGACAGTTACAGGACAGGCTAA CACCAATGGAGGCTTTACTTCAGACAAGATATGGATTATATAGCTCACCATTTGATCCAGTCCTCTTTGATTTGGAGATGAGTGGCTCTT CTTGTAAAAATGTTTATAACAGCAGCATTGGTGTCCAGTCAGATGAAATTGATTTATCAGATGTCCTTTCAGGAAATGGAAAGGTCAGTA GTTGCACAGCTGCTGAGGGTAGTTTCACATCTCTCACTGGACTTTTGGAAGTTGAACCTCTGCACTTTACTTGTGTGTCAACTAGTGATG GAACCAGAATAGAAAGGGATGATGCAATGAGTTCCTTCGGGGTTACTCCTGCAGTAGGTGGACTATCATCTGGGACAGTTGGGGAAGCCT CGACAGCCCTGAGTTCAGCAGCCCAGGTAGCTTTGCAGTCTCTCTCTCATGCAATGGCTTCAGCCGAGCAACAGCTACAGGTGCTGCAAG AGAAACAGCAGCAGCTTTTGAAGCTTCAGCAACAGAAAGCAAAGCTGGAAGCCAAGTTACATCAGACAACAGCTGCAGCAGCTGCAGCAG CATCAGCAGTAGGTCCTGTTCACAACTCTGTGCCTTCCAACCCAGTGGCTGCCCCTGGATTCTTCATTCATCCATCTGATGTTATTCCAC CCACTCCAAAAACAACACCTCTTTTTATGACTCCACCACTCACTCCACCCAATGAAGCAGTTTCCGTTGTGATTAATGCCGAACTTGCAC AGCTTTTCCCAGGCTCAGTCATTGATCCCCCAGCAGTCAATCTTGCTGCACATAACAAAAATTCCAACAAGTCCAGAATGAATCCACTTG GTTCTGGTCTAGCCCTTGCAATTTCTCATGCTTCACATTTTCTTCAACCTCCGCCTCACCAGTCCATTATTATAGAGCGAATGCATTCAG GAGCAAGAAGATTTGTGACCTTGGATTTTGGGAGGCCTATATTGTTGACTGATGTATTGATTCCCACTTGTGGAGACTTGGCCTCTTTGT CAATTGACATTTGGACATTAGGAGAAGAGGTGGATGGAAGGCGGTTGGTAGTGGCAACTGATATAAGCACTCATTCACTAATTCTTCATG ACTTAATACCACCTCCCGTGTGCAGATTCATGAAGATCACTGTTATTGGACGTTACGGGAGTACAAATGCCAGAGCCAAAATCCCATTAG GATTTTACTATGGTCATACCTACATCTTGCCTTGGGAAAGTGAACTGAAGTTAATGCATGATCCTCTAAAGGGAGAGGGAGAATCTGCAA ACCAGCCAGAAATTGACCAGCATTTAGCAATGATGGTTGCTTTGCAGGAGGATATACAGTGCAGGTATAACTTGGCTTGTCATCGTCTGG AAACCCTTTTGCAAAGTATTGATCTTCCTCCTCTAAACAGTGCTAACAATGCACAGTACTTTTTACGAAAACCAGATAAGGCAGTTGAGG AAGACAGTAGGGTTTTTTCTGCTTATCAAGATTGTATTCAGCTACAGCTTCAACTAAATTTGGCTCATAATGCAGTGCAGAGGCTCAAAG TGGCGCTAGGTGCAAGCCGGAAGATGTTGAGTGAAACATCAAATCCAGAAGATTTAATTCAGACATCTTCCACAGAGCAGTTACGTACTA TCATCAGATATTTACTGGACACTTTGCTCAGCCTGCTTCATGCTTCTAATGGACACTCTGTTCCTGCAGTTTTGCAGAGCACATTTCATG CCCAGGCCTGTGAAGAGCTCTTTAAACACTTGTGCATCAGTGGAACCCCAAAGATACGGTTACATACTGGTCTTCTTCTTGTTCAACTGT GTGGTGGTGAAAGGTGGTGGGGTCAATTTCTTTCTAATGTCCTTCAGGAATTGTACAATTCGGAACAGCTTCTCATCTTTCCACAGGATA GGGTCTTCATGTTACTTTCCTGCATTGGTCAAAGATCACTTAGTAATAGTGGAGTATTAGAAAGCTTACTTAATCTCTTGGATAATTTAT TGTCACCTCTTCAGCCACAGTTACCCATGCATAGGAGGACAGAAGGAGTACTAGATATTCCCATGATCAGTTGGGTTGTTATGCTGGTGT CCAGGTTGCTGGATTATGTGGCAACTGTTGAAGATGAAGCAGCAGCTGCAAAGAAACCTTTGAATGGTAATCAGTGGAGTTTTATTAACA ATAATCTACACACTCAGAGCTTAAATAGATCTTCTAAAGGCAGCAGTAGCCTTGATAGATTATATTCCAGAAAAATCAGAAAGCAGCTTG TTCATCATAAACAGCAACTTAACCTACTAAAAGCAAAGCAGAAGGCATTGGTAGAACAGATGGAAAAAGAAAAAATACAAAGTAACAAAG GATCATCATATAAACTCCTGGTAGAACAAGCAAAACTAAAGCAGGCCACTTCAAAGCACTTTAAGGATTTAATTCGTTTACGTCGGACAG CAGAATGGTCCCGTTCTAATTTAGACACAGAAGTTACAACAGCAAAAGAAAGTCCTGAGATAGAACCACTTCCATTTACTCTGGCCCATG AGCGTTGTATCTCAGTAGTCCAGAAACTTGTTCTGTTTCTTCTCTCCATGGACTTTACATGTCATGCAGATCTCTTATTGTTTGTTTGTA AGGTTCTTGCACGCATTGCAAATGCCACGAGGCCAACTATTCATCTGTGTGAGATTGTGAACGAACCCCAGCTGGAAAGACTGCTGTTAC TTTTGGTTGGAACTGACTTCAATAGAGGAGATATATCTTGGGGTGGTGCTTGGGCTCAGTATTCCTTAACTTGCATGCTACAAGATATTT TAGCAGGAGAATTACTGGCTCCAGTAGCCGCAGAAGCCATGGAGGAAGGAACAGTGGGTGATGATGTAGGTGCGACAGCTGGTGACTCTG ATGACTCCCTTCAACAGTCCTCAGTTCAGTTGCTGGAAACTATAGATGAACCTTTGACACATGACATAACAGGTGCACCTCCTCTGTCCT CTTTGGAAAAAGATAAAGAAATTGACCTTGAGTTACTTCAGGATCTAATGGAAGTTGACATTGATCCTTTAGATATTGATTTGGAAAAGG ACCCTCTTGCAGCCAAGGTTTTTAAGCCAATAAGCAGTACATGGTATGATTATTGGGGTGCTGATTATGGGACCTACAATTACAACCCTT ACATTGGAGGTCTGGGAATTCCTGTAGCAAAGCCACCAGCAAACACGGAGAAGAACGGATCACAGACAGTTAGCGTTTCAGTCTCTCAGG CCCTGGATGCTCGCCTAGAAGTTGGACTTGAACAGCAAGCAGAACTGATGTTGAAAATGATGTCTACTCTGGAGGCAGATTCCATTTTAC AGGCATTAACAAATACATCTCCTACATTATCACAGTCTCCCACTGGAACAGATGATTCACTTCTAGGGGGTTTACAAGCAGCAAACCAAA CCAGCCAGCTTATTATACAGTTATCATCTGTCCCAATGTTAAATGTTTGTTTCAACAAACTTTTTTCCATGCTTCAAGTCCATCATGTTC AGTTGGAGTCACTTCTCCAATTGTGGCTCACACTGAGCCTGAATTCTAGTTCAACTGGAAACAAAGAAAATGGAGCAGACATATTTTTAT ATAATGCTAATAGGATACCTGTTATTTCATTAAATCAAGCATCAATAACTAGCTTTCTCACAGTGTTAGCTTGGTATCCCAATACTTTGC TCCGGACATGGTGCCTTGTGCTTCATAGCCTAACACTCATGACAAACATGCAGCTTAATTCTGGTTCCAGCAGTGCCATTGGAACTCAGG AGAGTACTGCTCATTTGTTGGTTTCAGATCCAAACCTAATTCATGTATTAGTGAAATTTCTTTCTGGCACCAGTCCACATGGAACAAATC AACACAGTCCACAGGTTGGTCCTACAGCTACACAAGCTATGCAAGAATTTCTTACTCGATTACAAGTGCATCTTTCTTCAACATGTCCTC AGATATTCAGTGAATTTTTGCTCAAGCTAATTCATATACTTTCAACTGAAAGGGGTGCTTTCCAGACAGGCCAAGGACCTCTCGATGCCC AAGTGAAGCTCTTAGAATTCACTCTGGAGCAGAATTTTGAAGTCGTTTCAGTTAGTACTATTTCTGCCGTGATAGAATCGGTTACATTTT TAGTGCACCACTATATCACTTGCTCAGACAAAGTAATGTCAAGAAGTGGATCAGATAGCTCCGTGGGTGCTCGAGCATGCTTTGGGGGAC TCTTTGCCAATCTTATTCGTCCGGGTGATGCAAAAGCAGTTTGTGGCGAAATGACAAGAGATCAACTCATGTTTGATTTGTTAAAACTTG TTAACATTTTAGTGCAGCTGCCTCTTTCAGGCAATAGGGAATACAGTGCAAGAGTGTCTGTGACCACAAATACAACAGATAGTGTTTCAG ATGAAGAAAAAGTCTCAGGAGGCAAAGATGGCAATGGAAGCAGTACCAGTGTTCAAGGATCGCCTGCATATGTTGCTGACTTAGTCTTAG CCAACCAACAAATTATGAGCCAGATTTTGTCTGCTCTGGGCCTGTGTAATAGCAGTGCCATGGCAATGATAATTGGAGCAAGTGGATTAC ATCTCACTAAACATGAAAACTTTCATGGTGGGTTGGATGCCATATCAGTTGGGGATGGATTATTTACCATACTGACAACCCTTAGTAAAA AAGCTTCTACAGTCCACATGATGCTGCAGCCAATTTTAACATACATGGCCTGTGGATATATGGGCAGACAAGGCTCTCTTGCTACTTGCC AGTTATCTGAGCCATTATTGTGGTTCATTTTGAGAGTATTGGATACTAGTGATGCCTTGAAAGCATTTCATGATATGGGTGGTGTTCAGC TCATATGCAATAATATGGTTACTAGTACAAGGGCTATTGTGAACACTGCAAGAAGTATGGTATCAACTATTATGAAATTTCTTGACTCTG GTCCAAATAAAGCTGTTGACAGCACATTGAAAACAAGAATACTAGCTTCTGAGCCTGACAATGCTGAAGGGATTCATAACTTTGCACCCC TCGGTACAATCACATCTAGCAGTCCTACTGCCCAACCAGCTGAAGTGCTATTGCAGGCCACACCTCCTCACAGAAGAGCTCGCTCTGCTG CTTGGTCCTACATCTTTCTTCCAGAGGAGGCTTGGTGTGACCTTACCATTCACCTTCCTGCAGCAGTGCTGCTTAAGGAGATACATATCC AGCCTCATCTTGCATCTCTTGCAACCTGCCCTTCCTCAGTGTCTGTTGAAGTAAGTGCAGATGGGGTAAATATGCTACCTTTGTCCACTC CTGTTGTCACAAGTGGCCTCACCTACATAAAAATTCAGCTTGTAAAAGCCGAAGTAGCTTCTGCTGTCTGCCTTAGACTACATCGTCCAC GGGATGCCAGCACATTAGGCCTTTCACAAATTAAATTATTGGGGCTCACTGCTTTTGGTACCACCTCTTCTGCAACAGTTAATAATCCAT TCCTTCCATCTGAAGATCAGGTATCCAAAACAAGTATTGGATGGTTACGGTTATTACATCATTGCCTTACTCACATAAGTGATCTAGAAG GAATGATGGCAAGTGCAGCTGCACCTACTGCTAATCTGCTGCAGACTTGTGCGGCCTTATTGATGTCACCTTACTGTGGAATGCATTCAC CCAACATCGAGGTTGTGCTTGTAAAGATAGGACTGCAGTCTACTAGAATTGGCCTGAAGCTCATAGACATTCTCCTGAGAAATTGTGCAG CATCAGGCAGTGATCCTACAGATTTGAATAGTCCTTTACTTTTTGGAAGACTAAATGGACTCTCTTCTGACTCTACGATAGATATTCTTT ACCAGCTTGGAACAACTCAGGATCCTGGTACAAAAGACAGAATTCAGGCCTTGTTAAAATGGGTTAGTGATTCTGCAAGAGTGGCTGCTA TGAAGAGAAGTGGCAGGATGAACTACATGTGTCCTAACTCCTCAACAGTAGAGTATGGTCTTCTGATGCCATCTCCTTCTCATTTGCACT GTGTAGCAGCCATTCTGTGGCATAGTTATGAGCTGCTTGTAGAATATGACTTACCAGCACTCCTGGACCAAGAGCTCTTTGAGTTACTTT TTAATTGGTCCATGTCTCTTCCCTGCAATATGGTTTTGAAGAAAGCTGTTGACAGTCTACTTTGCTCAATGTGTCACGTACACCCAAACT ATTTTTCTTTGCTCATGGGCTGGATGGGAATTACCCCTCCTCCAGTGCAATGTCATCATAGACTGTCCATGACAGATGATAGCAAAAAGC AGGATCTTAGTTCATCTTTAACAGATGACTCTAAAAATGCACAAGCACCTCTCGCATTAACTGAATCACATTTGGCTACCCTTGCTTCCT CTTCTCAATCTCCTGAAGCTATTAAACAATTACTAGACTCAGGTTTGCCTTCTCTTCTTGTGAGGAGTCTGGCTAGTTTCTGCTTTAGCC ACATTTCTAGCTCAGAAAGCATTGCCCAGTCAATAGATATTTCCCAGGACAAACTCAGGCGCCATCATGTCCCACAACAATGTAATAAGA TGCCTATCACAGCCGACCTAGTTGCTCCTATTCTTAGGTTTTTGACAGAAGTTGGCAATAGCCATATTATGAAAGATTGGCTTGGTGGTT CTGAAGTCAATCCACTATGGACAGCACTTCTGTTTTTATTGTGTCACTCTGGGTCCACTTCTGGAAGCCATAATTTAGGTGCACAACAGA CCAGTGCAAGATCAGCTTCTCTTTCTTCAGCTGCTACAACAGGACTGACTACTCAACAGCGCACAGCAATTGAGAATGCAACTGTTGCGT TCTTTCTACAGTGCATTTCATGCCATCCTAATAATCAAAAGCTGATGGCACAGGTTCTTTGTGAACTATTTCAGACATCTCCTCAAAGAG GGAACCTTCCAACATCTGGGAACATTTCAGGGTTTATACGAAGATTATTTTTACAGTTGATGCTGGAAGATGAGAAAGTGACAATGTTTC TTCAGTCTCCATGTCCACTGTACAAAGGTAGAATTAATGCTACTAGCCACGTCATCCAGCATCCAATGTATGGAGCAGGCCACAAATTCC GTACTCTTCATTTGCCAGTCTCAACAACATTATCAGATGTTCTTGACAGAGTGTCAGATACTCCAAGTATCACAGCTAAATTAATTAGTG AACAAAAAGATGACAAAGAAAAGAAAAACCATGAAGAGAAAGAAAAAGTTAAAGCGGAAAATGGATTTCAAGACAATTACAGTGTTGTTG TTGCCTCTGGGCTGAAGTCTCAATCTAAACGTGCTGTGTCAGCTACACCACCTCGCCCACCATCCAGGAGGGGGAGGACAATACCTGATA AAATAGGAAGTACTTCAGGAGCAGAGGCTGCCAACAAAATAATTACTGTCCCAGTGTTTCACCTGTTTCACAAACTCTTGGCAGGCCAGC CATTGCCAGCTGAAATGACACTTGCCCAGCTTTTAACTCTCCTATATGACCGAAAACTTCCTCAGGGTTACCGCTCAATAGATCTGACTG TTAAATTGGGATCAAGAGTTATAACAGACCCCAGTCTATCAAAAACAGATTCTTATAAAAGACTACACCCTGAAAAAGATCATGGAGACT TACTTGCTAGCTGTCCAGAAGATGAGGCTCTCACTCCAGGTGATGAATGCATGGATGGGATACTGGATGAATCTTTGCTTGAAACCTGTC CAATTCAGTCACCATTACAAGTTTTTGCAGGAATGGGTGGACTGGCTCTTATTGCTGAAAGACTACCCATGCTATATCCAGAAGTAATTC AACAGGTGAGTGCTCCAGTTGTAACATCTACCACTCAGGAAAAGCCGAAGGATAGCGATCAGTTTGAATGGGTGACCATTGAACAGTCAG GGGAGTTAGTTTATGAAGCACCAGAAACTGTTGCGGCTGAACCTCCACCTATCAAGTCAGCAGTACAGACCATGTCTCCCATACCTGCCC ATTCTTTGGCTGCTTTTGGATTATTTCTTCGTCTTCCGGGCTATGCGGAAGTGCTACTGAAAGAGAGAAAACATGCCCAGTGCCTTCTTC GATTGGTATTGGGAGTGACAGATGATGGAGAAGGAAGTCATATTCTTCAATCTCCATCAGCCAATGTGCTTCCAACCCTTCCTTTCCACG TCCTTCGTAGCTTGTTTAGCACTACACCTTTGACAACTGATGATGGTGTACTTCTAAGGCGGATGGCATTGGAAATTGGAGCCTTACACC TCATTCTTGTCTGTCTCTCTGCTTTGAGCCACCATTCCCCACGAGTTCCAAACTCTAGCGTGAATCAAACTGAGCCACAGGTGTCAAGCT CTCATAACCCTACATCAACAGAAGAACAACAGTTATATTGGGCCAAAGGGACTGGCTTTGGAACAGGCTCTACAGCTTCTGGGTGGGATG TGGAACAAGCCTTAACTAAGCAAAGGCTGGAAGAGGAACATGTTACCTGCCTTCTGCAGGTTCTTGCCAGTTACATAAATCCCGTCAGTA GTGCGGTAAATGGAGAAGCTCAGTCATCTCATGAGACTAGAGGGCAGAACAGTAATGCCCTTCCTTCTGTACTTCTCGAGCTTCTCAGTC AGTCCTGCCTCATCCCAGCCATGTCATCTTATCTACGAAATGATTCAGTTCCGAAAGACCCGAAACCCCAGTGGAGACGGGTAGCATGGA GTTACGATTGTACCCTACTGGCCTATGCCGAAAGCACAGGAACTGTGAGGGTGTTTGATCTCATGGGAAGTGAACTCTTTGTCATTTCCC CGGCATCTAGTTTTATAGGTGACTTAAGCTATGCCATTGCTGGGTTGATATTTTTAGAATATAAAGCAAGTGCACAGTGGTCTGCAGAAC TCCTGGTCATCAATTACCGAGGAGAACTTAGAAGTTACCTTGTAAGTGTTGGAACAAATCAGAGCTACCAAGAAAGTCACTGTTTCAGCT TCAGTAGTCATTATCCTCATGGAATCAACACAGCTATTTACCACCCTGGTCACAGACTTTTACTTGTTGGTGGATGTGAAACTGCTGAAG TAGGCATGTCAAAAGCTTCTAGCTGTGGCCTTTCTGCCTGGAGAGTTCTTTCAGGATCACCGTATTATAAGCAGGTTACTAATGGTGGAG ACGGGGTTACTGCAGTACCGAAGACACTGGGATTATTAAGGATGTTAAGTGTCAAGTTTTACAGTCGCCAGGGACAAGAACAGGATGGAA TTTTTAAGATGAGCCTTTCTCCAGATGGGATGCTCCTGGCAGCCATTCACTTCTCAGGGAAACTGAGCATCTGGGCGATTCCATCTCTGA AGCAACAAGGGGAATGGGGTCAAAATGAGCAGCCAGGCTATGATGACCTTAATCCTGATTGGAGGCTCTCTACTGAGAAGAGAAAAAAAA TCAAAGATAAAGAGTCCTTTTACCCACTGATAGATGTCAATTGGTGGGCAGACAGTGCAGTGACTTTAGCTCGATGCTCTGGTGCTTTAA CTGTTTCATCTGTGAAAACTTTGAAGAATTTACTGGGAAAATCCTGTGAATGGTTTGAACCATCACCTCAAGTCACTGCTACCCATGATG GGGGATTTTTAAGTTTGGAGTGTGAGATTAAACTTGCCCCCAAACGATCTCGTTTGGAGACTAGAGCTGGAGAAGAAGATGAAGGAGAAG AGGATTCTGATTCTGATTATGAAATATCTGCCAAGGCTCGCTACTTTGGTTATATAAAACAGGGCCTTTACTTGGTGACTGAAATGGAGC GATTTGCACCACCACGGAAACGCCCACGAACCATTACTAAAAACTACCGCCTTGTGAGTTTGCGCTCCACGACACCAGAGGAACTTTATC AGAGGAAGATTGAAAGTGAAGAGTATGAGGAAGCCTTGTCCTTGGCTCATACCTACGGCCTGGATACTGACCTTGTATATCAGAGGCAGT GGAGGAAGTCAGCGGTCAACGTTGCTTCAATTCAGAATTATTTGAGTAAAATAAAGAAGCGATCCTGGGTTCTCCATGAGTGTTTGGAAA GAGTTCCTGAAAATGTGGATGCTGCAAAAGAACTGCTTCAGTATGGATTAAAAGGCACAGACCTGGAGGCTCTTTTAGCAATAGGGAAAG GAGCAGATGATGGCAGATTTACATTACCTGGTGAAATAGACATTGACAGTATCTCCTATGAAGAGCTTTCACCACCTGATGAAGAGCCTG CCAAGAATAAAAAGGAAAAGGAGCTCAAGAAGAGACAAGAACTACTGAAATTAGTGAACTTTTCCAAGTTGACACTGGAACAAAAGGAAC TTTGCCGTTGTAGACGGAAGTTATTAACCTACTTAGATCGACTTGCAACATATGAGGAAATCCTAGGAGTGCCTCATGCATCTGAACAGA GATATGATGCTGAATTCTTTAAGAAATTCAGAAATCAGAATATTGTTCTCTCAGCAAGAACTTATGCTCAGGAAAGTAATGTACAAGCCC TGGAAATTCTGTTTACTTACCATGGTTCCGACCTGCTTCCTCATCGCCTTGCAATTCTGTCCAACTTTCCAGAGACCACTTCTCCACATG AATATTCTGTTTTGCTGCCCGAAGCTTGTTTTAACGGTGACTCCCTGATGATCATTCCTTGGCATGAACATAAACACCGAGCTAAAGATT GGTGCGAGGAGTTGGCTTGCAGAATGGTTGTTGAGCCGAATCTCCAAGATGAAAGTGAATTCTTGTATGCTGCACAGCCTGAGTTACTAA GGTTCAGGATGACCCAGCTTACGGTGGAGAAGGTTATGGACTGGTATCAGACCAGAGCAGAGGAAATAGAGCATTATGCTCGGCAGCTGC AGCAAAAAATTATTCCTGATCAGGACCAACTGATGGCAATAGCACTAGAGTGCATCTATACCTGTGAACGAAATGATCAACTCTGTCTTT GCTATGACCTACTAGAATGTCTGCCAGAAAGAGGATATGGTGATAAGACAGAGGCAACCACAAAGCTTCATGACATGGTAGACCAACTGG AACAAATTCTCAGTGTGTCAGAGCTTTTGGAAAAACATGGACTCGAGAAACCAATTTCATTTGTTAAAAACACTCAATCTAGCTCAGAAG AGGCACGCAAGCTGATGGTTAGATTGACGAGGCACACTGGCCGGAAGCAGCCTCCTGTCAGTGAGTCTCATTGGAGAACGTTGCTGCAAG ACATGTTAACTATGCAGCAGAATGTATACACATGTCTAGATTCTGATGCCTGCTATGAGATATTTACAGAAAGCCTTCTGTGCTCTAGTC GCCTTGAAAACATCCACCTGGCTGGACAGATGATGCACTGCAGTGCTTGTTCAGAAAATCCTCCAGCTGGTATAGCCCATAAAGGGAAAC CCCACTACAGGGTCAGCTACGAAAAGAGTATTGACTTGGTTTTGGCTGCCAGCAGAGAGTACTTCAATTCTTCTACCAACCTCACTGATA GCTGCATGGATCTAGCCAGGTGCTGCTTACAACTGATAACAGACAGACCCCCTGCCATTCAAGAGGAGCTAGATCTTATCCAAGCCGTTG GATGTCTTGAAGAATTTGGGGTAAAGATCCTGCCTTTGCAAGTGCGATTGTGCCCTGATCGGATCAGTCTCATCAAGGAGTGTATTTCCC AGTCCCCCACATGCTATAAACAATCCACCAAGCTTCTGGGCCTTGCTGAGCTGCTGAGGGTTGCAGGTGAGAACCCAGAAGAAAGGCGGG GACAGGTTCTAATCCTTTTAGTGGAGCAGGCACTTCGCTTCCATGACTACAAAGCAGCCAGTATGCATTGTCAGGAGCTGATGGCCACAG GTTATCCTAAAAGTTGGGATGTTTGTAGCCAGTTAGGACAATCAGAAGGTTACCAGGACTTGGCCACTCGTCAAGAGCTCATGGCTTTTG CTTTGACACATTGCCCTCCTAGCAGCATTGAACTTCTTTTGGCAGCTAGCAGCTCTCTGCAGACAGAAATTCTTTATCAAAGAGTGAATT TCCAGATCCATCATGAAGGAGGGGAAAATATCAGTGCTTCACCATTAACTAGTAAAGCAGTACAAGAGGATGAAGTAGGTGTTCCAGGTA GCAATTCAGCTGACCTATTGCGCTGGACCACTGCTACCACCATGAAAGTCCTTTCCAACACCACAACCACCACCAAAGCGGTGCTGCAGG CCGTCAGTGATGGGCAGTGGTGGAAGAAGTCTTTAACTTACCTTCGACCCCTTCAGGGGCAAAAATGTGGTGGTGCATATCAAATCGGAA CTACAGCCAATGAAGATCTAGAGAAACAAGGGTGTCATCCTTTTTATGAATCTGTCATCTCAAATCCTTTTGTCGCTGAGTCTGAAGGGA CCTATGACACCTATCAGCATGTTCCAGTGGAAAGCTTTGCAGAAGTATTGCTGAGAACTGGAAAATTGGCAGAGGCTAAAAATAAAGGAG AAGTATTTCCAACAACTGAAGTTCTCTTGCAACTAGCAAGTGAAGCCTTGCCAAATGACATGACCTTGGCTCTTGCTTACCTTCTTGCCT TACCACAAGTGTTAGATGCTAACCGGTGCTTTGAAAAGCAGTCCCCCTCTGCATTATCTCTCCAGCTGGCAGCGTATTACTATAGCCTCC AGATCTATGCCCGATTGGCCCCATGTTTCAGGGACAAGTGCCATCCTCTTTACAGGGCTGATCCCAAAGAACTAATCAAGATGGTCACCA GGCATGTGACTCGACATGAGCACGAAGCCTGGCCTGAAGACCTTATTTCACTGACCAAGCAGTTACACTGCTACAATGAACGTCTCCTGG ATTTCACTCAGGCGCAGATCCTTCAGGGCCTTCGGAAGGGTGTGGACGTGCAGCGGTTTACTGCAGATGACCAGTATAAAAGGGAAACTA TCCTTGGTCTGGCAGAAACTCTAGAGGAAAGCGTCTACAGCATTGCTATTTCTCTGGCACAACGTTACAGTGTCTCCCGCTGGGAAGTTT TTATGACCCATTTGGAGTTCCTCTTCACGGACAGTGGTTTGTCCACACTAGAAATTGAAAATAGAGCCCAAGACCTTCATCTCTTTGAGA CTTTGAAGACTGATCCAGAAGCCTTTCACCAGCACATGGTCAAGTATATTTACCCTACTATTGGTGGCTTTGATCACGAAAGGCTGCAGT ATTATTTCACTCTTCTGGAAAACTGTGGCTGTGCAGATTTGGGGAACTGTGCCATTAAACCAGAAACCCACATTCGACTGCTGAAGAAGT TTAAGGTTGTTGCATCAGGTCTTAATTACAAAAAGCTGACAGATGAAAACATGAGTCCTCTTGAAGCATTGGAGCCAGTTCTTTCAAGTC AAAATATCTTGTCTATTTCCAAACTTGTTCCCAAAATCCCTGAAAAGGATGGACAGATGCTTTCCCCAAGCTCTCTGTACACCATCTGGT TACAGAAGTTGTTCTGGACTGGAGACCCTCATCTCATTAAACAAGTCCCAGGCTCTTCACCGGAGTGGCTTCATGCCTATGATGTCTGCA TGAAGTACTTTGATCGTCTCCACCCAGGTGACCTCATCACTGTGGTAGATGCAGTTACATTTTCTCCAAAAGCTGTGACCAAGCTGTCTG TGGAAGCCCGTAAAGAGATGACTAGAAAGGCTATTAAGACAGTCAAACATTTTATTGAGAAGCCAAGGAAAAGAAACTCAGAAGACGAAG CTCAAGAAGCTAAGGATTCTAAAGTTACCTATGCAGATACTTTGAATCATCTGGAGAAATCACTTGCCCACCTGGAAACCCTGAGCCACA GCTTCATCCTTTCTCTGAAGAATAGTGAGCAGGAAACACTGCAAAAATACAGTCACCTCTATGATCTGTCCCGATCAGAAAAAGAGAAAC TTCATGATGAAGCTGTGGCTATTTGTTTAGATGGTCAGCCTCTAGCAATGATTCAGCAGCTGCTAGAGGTGGCAGTTGGCCCTCTTGACA TCTCACCCAAGGATATAGTGCAGAGTGCAATCATGAAAATAATTTCTGCATTGAGTGGTGGCAGTGCTGACCTTGGTGGGCCAAGGGACC CACTGAAGGTCCTGGAAGGTGTTGTTGCAGCAGTCCACGCCAGTGTGGACAAGGGTGAGGAGCTGGTTTCACCTGAGGACCTGCTGGAGT GGCTGCGGCCTTTCTGTGCTGATGACGCCTGGCCGGTGCGGCCCCGCATTCACGTGCTGCAGATTTTGGGGCAATCATTTCACCTGACTG AGGAGGACAGCAAGCTCCTCGTGTTCTTTAGAACTGAAGCCATTCTCAAAGCCTCCTGGCCCCAGAGACAGGTAGACATAGCTGACATTG AGAATGAAGAGAACCGCTACTGTCTATTCATGGAACTCCTGGAATCTAGTCACCACGAGGCTGAATTTCAGCACTTGGTTTTACTTTTGC AAGCTTGGCCACCTATGAAAAGTGAATATGTCATAACCAATAATCCATGGGTGAGACTAGCTACAGTGATGCTAACCAGATGTACGATGG AGAACAAGGAAGGATTGGGGAATGAAGTTTTGAAAATGTGTCGCTCTTTGTATAACACCAAGCAGATGCTGCCTGCAGAGGGTGTGAAGG AGCTGTGTCTGCTGCTGCTTAACCAGTCCCTCCTGCTTCCATCTCTGAAACTTCTCCTCGAGAGCCGAGATGAGCATCTGCACGAGATGG CACTGGAGCAAATCACGGCAGTCACTACGGTGAATGATTCCAATTGTGACCAAGAACTTCTTTCCCTGCTCCTGGATGCCAAGCTGCTGG TGAAGTGTGTCTCCACTCCCTTCTATCCACGTATTGTTGACCACCTCTTGGCTAGCCTCCAGCAAGGGCGCTGGGATGCAGAGGAGCTGG GCAGACACCTGCGGGAGGCCGGCCATGAAGCCGAAGCCGGGTCTCTCCTTCTGGCCGTGAGGGGGACTCACCAGGCCTTCAGAACCTTCA GTACAGCCCTCCGCGCAGCACAGCACTGGGTGTGAGGGCCACCTGTGGCCCTGCTCCTTAGCAGAAAAAGCATCTGGAGTTGAATGCTGT >9762_9762_2_BIRC6-NBAS_BIRC6_chr2_32774548_ENST00000421745_NBAS_chr2_15679480_ENST00000441750_length(amino acids)=6506AA_BP=4381 MVTGGGAAPPGTVTEPLPSVIVLSAGRKMAAAAAAASGPGCSSAAGAGAAGVSEWLVLRDGCMHCDADGLHSLSYHPALNAILAVTSRGT IKVIDGTSGATLQASALSAKPGGQVKCQYISAVDKVIFVDDYAVGCRKDLNGILLLDTALQTPVSKQDDVVQLELPVTEAQQLLSACLEK VDISSTEGYDLFITQLKDGLKNTSHETAANHKVAKWATVTFHLPHHVLKSIASAIVNELKKINQNVAALPVASSVMDRLSYLLPSARPEL GVGPGRSVDRSLMYSEANRRETFTSWPHVGYRWAQPDPMAQAGFYHQPASSGDDRAMCFTCSVCLVCWEPTDEPWSEHERHSPNCPFVKG EHTQNVPLSVTLATSPAQFPCTDGTDRISCFGSGSCPHFLAAATKRGKICIWDVSKLMKVHLKFEINAYDPAIVQQLILSGDPSSGVDSR RPTLAWLEDSSSCSDIPKLEGDSDDLLEDSDSEEHSRSDSVTGHTSQKEAMEVSLDITALSILQQPEKLQWEIVANVLEDTVKDLEELGA NPCLTNSKSEKTKEKHQEQHNIPFPCLLAGGLLTYKSPATSPISSNSHRSLDGLSRTQGESISEQGSTDNESCTNSELNSPLVRRTLPVL LLYSIKESDEKAGKIFSQMNNIMSKSLHDDGFTVPQIIEMELDSQEQLLLQDPPVTYIQQFADAAANLTSPDSEKWNSVFPKPGTLVQCL RLPKFAEEENLCIDSITPCADGIHLLVGLRTCPVESLSAINQVEALNNLNKLNSALCNRRKGELESNLAVVNGANISVIQHESPADVQTP LIIQPEQRNVSGGYLVLYKMNYATRIVTLEEEPIKIQHIKDPQDTITSLILLPPDILDNREDDCEEPIEDMQLTSKNGFEREKTSDISTL GHLVITTQGGYVKILDLSNFEILAKVEPPKKEGTEEQDTFVSVIYCSGTDRLCACTKGGELHFLQIGGTCDDIDEADILVDGSLSKGIEP SSEGSKPLSNPSSPGISGVDLLVDQPFTLEILTSLVELTRFETLTPRFSATVPPCWVEVQQEQQQRRHPQHLHQQHHGDAAQHTRTWKLQ TDSNSWDEHVFELVLPKACMVGHVDFKFVLNSNITNIPQIQVTLLKNKAPGLGKVNALNIEVEQNGKPSLVDLNEEMQHMDVEESQCLRL CPFLEDHKEDILCGPVWLASGLDLSGHAGMLTLTSPKLVKGMAGGKYRSFLIHVKAVNERGTEEICNGGMRPVVRLPSLKHQSNKGYSLA SLLAKVAAGKEKSSNVKNENTSGTRKSENLRGCDLLQEVSVTIRRFKKTSISKERVQRCAMLQFSEFHEKLVNTLCRKTDDGQITEHAQS LVLDTLCWLAGVHSNGPGSSKEGNENLLSKTRKFLSDIVRVCFFEAGRSIAHKCARFLALCISNGKCDPCQPAFGPVLLKALLDNMSFLP AATTGGSVYWYFVLLNYVKDEDLAGCSTACASLLTAVSRQLQDRLTPMEALLQTRYGLYSSPFDPVLFDLEMSGSSCKNVYNSSIGVQSD EIDLSDVLSGNGKVSSCTAAEGSFTSLTGLLEVEPLHFTCVSTSDGTRIERDDAMSSFGVTPAVGGLSSGTVGEASTALSSAAQVALQSL SHAMASAEQQLQVLQEKQQQLLKLQQQKAKLEAKLHQTTAAAAAAASAVGPVHNSVPSNPVAAPGFFIHPSDVIPPTPKTTPLFMTPPLT PPNEAVSVVINAELAQLFPGSVIDPPAVNLAAHNKNSNKSRMNPLGSGLALAISHASHFLQPPPHQSIIIERMHSGARRFVTLDFGRPIL LTDVLIPTCGDLASLSIDIWTLGEEVDGRRLVVATDISTHSLILHDLIPPPVCRFMKITVIGRYGSTNARAKIPLGFYYGHTYILPWESE LKLMHDPLKGEGESANQPEIDQHLAMMVALQEDIQCRYNLACHRLETLLQSIDLPPLNSANNAQYFLRKPDKAVEEDSRVFSAYQDCIQL QLQLNLAHNAVQRLKVALGASRKMLSETSNPEDLIQTSSTEQLRTIIRYLLDTLLSLLHASNGHSVPAVLQSTFHAQACEELFKHLCISG TPKIRLHTGLLLVQLCGGERWWGQFLSNVLQELYNSEQLLIFPQDRVFMLLSCIGQRSLSNSGVLESLLNLLDNLLSPLQPQLPMHRRTE GVLDIPMISWVVMLVSRLLDYVATVEDEAAAAKKPLNGNQWSFINNNLHTQSLNRSSKGSSSLDRLYSRKIRKQLVHHKQQLNLLKAKQK ALVEQMEKEKIQSNKGSSYKLLVEQAKLKQATSKHFKDLIRLRRTAEWSRSNLDTEVTTAKESPEIEPLPFTLAHERCISVVQKLVLFLL SMDFTCHADLLLFVCKVLARIANATRPTIHLCEIVNEPQLERLLLLLVGTDFNRGDISWGGAWAQYSLTCMLQDILAGELLAPVAAEAME EGTVGDDVGATAGDSDDSLQQSSVQLLETIDEPLTHDITGAPPLSSLEKDKEIDLELLQDLMEVDIDPLDIDLEKDPLAAKVFKPISSTW YDYWGADYGTYNYNPYIGGLGIPVAKPPANTEKNGSQTVSVSVSQALDARLEVGLEQQAELMLKMMSTLEADSILQALTNTSPTLSQSPT GTDDSLLGGLQAANQTSQLIIQLSSVPMLNVCFNKLFSMLQVHHVQLESLLQLWLTLSLNSSSTGNKENGADIFLYNANRIPVISLNQAS ITSFLTVLAWYPNTLLRTWCLVLHSLTLMTNMQLNSGSSSAIGTQESTAHLLVSDPNLIHVLVKFLSGTSPHGTNQHSPQVGPTATQAMQ EFLTRLQVHLSSTCPQIFSEFLLKLIHILSTERGAFQTGQGPLDAQVKLLEFTLEQNFEVVSVSTISAVIESVTFLVHHYITCSDKVMSR SGSDSSVGARACFGGLFANLIRPGDAKAVCGEMTRDQLMFDLLKLVNILVQLPLSGNREYSARVSVTTNTTDSVSDEEKVSGGKDGNGSS TSVQGSPAYVADLVLANQQIMSQILSALGLCNSSAMAMIIGASGLHLTKHENFHGGLDAISVGDGLFTILTTLSKKASTVHMMLQPILTY MACGYMGRQGSLATCQLSEPLLWFILRVLDTSDALKAFHDMGGVQLICNNMVTSTRAIVNTARSMVSTIMKFLDSGPNKAVDSTLKTRIL ASEPDNAEGIHNFAPLGTITSSSPTAQPAEVLLQATPPHRRARSAAWSYIFLPEEAWCDLTIHLPAAVLLKEIHIQPHLASLATCPSSVS VEVSADGVNMLPLSTPVVTSGLTYIKIQLVKAEVASAVCLRLHRPRDASTLGLSQIKLLGLTAFGTTSSATVNNPFLPSEDQVSKTSIGW LRLLHHCLTHISDLEGMMASAAAPTANLLQTCAALLMSPYCGMHSPNIEVVLVKIGLQSTRIGLKLIDILLRNCAASGSDPTDLNSPLLF GRLNGLSSDSTIDILYQLGTTQDPGTKDRIQALLKWVSDSARVAAMKRSGRMNYMCPNSSTVEYGLLMPSPSHLHCVAAILWHSYELLVE YDLPALLDQELFELLFNWSMSLPCNMVLKKAVDSLLCSMCHVHPNYFSLLMGWMGITPPPVQCHHRLSMTDDSKKQDLSSSLTDDSKNAQ APLALTESHLATLASSSQSPEAIKQLLDSGLPSLLVRSLASFCFSHISSSESIAQSIDISQDKLRRHHVPQQCNKMPITADLVAPILRFL TEVGNSHIMKDWLGGSEVNPLWTALLFLLCHSGSTSGSHNLGAQQTSARSASLSSAATTGLTTQQRTAIENATVAFFLQCISCHPNNQKL MAQVLCELFQTSPQRGNLPTSGNISGFIRRLFLQLMLEDEKVTMFLQSPCPLYKGRINATSHVIQHPMYGAGHKFRTLHLPVSTTLSDVL DRVSDTPSITAKLISEQKDDKEKKNHEEKEKVKAENGFQDNYSVVVASGLKSQSKRAVSATPPRPPSRRGRTIPDKIGSTSGAEAANKII TVPVFHLFHKLLAGQPLPAEMTLAQLLTLLYDRKLPQGYRSIDLTVKLGSRVITDPSLSKTDSYKRLHPEKDHGDLLASCPEDEALTPGD ECMDGILDESLLETCPIQSPLQVFAGMGGLALIAERLPMLYPEVIQQVSAPVVTSTTQEKPKDSDQFEWVTIEQSGELVYEAPETVAAEP PPIKSAVQTMSPIPAHSLAAFGLFLRLPGYAEVLLKERKHAQCLLRLVLGVTDDGEGSHILQSPSANVLPTLPFHVLRSLFSTTPLTTDD GVLLRRMALEIGALHLILVCLSALSHHSPRVPNSSVNQTEPQVSSSHNPTSTEEQQLYWAKGTGFGTGSTASGWDVEQALTKQRLEEEHV TCLLQVLASYINPVSSAVNGEAQSSHETRGQNSNALPSVLLELLSQSCLIPAMSSYLRNDSVPKDPKPQWRRVAWSYDCTLLAYAESTGT VRVFDLMGSELFVISPASSFIGDLSYAIAGLIFLEYKASAQWSAELLVINYRGELRSYLVSVGTNQSYQESHCFSFSSHYPHGINTAIYH PGHRLLLVGGCETAEVGMSKASSCGLSAWRVLSGSPYYKQVTNGGDGVTAVPKTLGLLRMLSVKFYSRQGQEQDGIFKMSLSPDGMLLAA IHFSGKLSIWAIPSLKQQGEWGQNEQPGYDDLNPDWRLSTEKRKKIKDKESFYPLIDVNWWADSAVTLARCSGALTVSSVKTLKNLLGKS CEWFEPSPQVTATHDGGFLSLECEIKLAPKRSRLETRAGEEDEGEEDSDSDYEISAKARYFGYIKQGLYLVTEMERFAPPRKRPRTITKN YRLVSLRSTTPEELYQRKIESEEYEEALSLAHTYGLDTDLVYQRQWRKSAVNVASIQNYLSKIKKRSWVLHECLERVPENVDAAKELLQY GLKGTDLEALLAIGKGADDGRFTLPGEIDIDSISYEELSPPDEEPAKNKKEKELKKRQELLKLVNFSKLTLEQKELCRCRRKLLTYLDRL ATYEEILGVPHASEQRYDAEFFKKFRNQNIVLSARTYAQESNVQALEILFTYHGSDLLPHRLAILSNFPETTSPHEYSVLLPEACFNGDS LMIIPWHEHKHRAKDWCEELACRMVVEPNLQDESEFLYAAQPELLRFRMTQLTVEKVMDWYQTRAEEIEHYARQLQQKIIPDQDQLMAIA LECIYTCERNDQLCLCYDLLECLPERGYGDKTEATTKLHDMVDQLEQILSVSELLEKHGLEKPISFVKNTQSSSEEARKLMVRLTRHTGR KQPPVSESHWRTLLQDMLTMQQNVYTCLDSDACYEIFTESLLCSSRLENIHLAGQMMHCSACSENPPAGIAHKGKPHYRVSYEKSIDLVL AASREYFNSSTNLTDSCMDLARCCLQLITDRPPAIQEELDLIQAVGCLEEFGVKILPLQVRLCPDRISLIKECISQSPTCYKQSTKLLGL AELLRVAGENPEERRGQVLILLVEQALRFHDYKAASMHCQELMATGYPKSWDVCSQLGQSEGYQDLATRQELMAFALTHCPPSSIELLLA ASSSLQTEILYQRVNFQIHHEGGENISASPLTSKAVQEDEVGVPGSNSADLLRWTTATTMKVLSNTTTTTKAVLQAVSDGQWWKKSLTYL RPLQGQKCGGAYQIGTTANEDLEKQGCHPFYESVISNPFVAESEGTYDTYQHVPVESFAEVLLRTGKLAEAKNKGEVFPTTEVLLQLASE ALPNDMTLALAYLLALPQVLDANRCFEKQSPSALSLQLAAYYYSLQIYARLAPCFRDKCHPLYRADPKELIKMVTRHVTRHEHEAWPEDL ISLTKQLHCYNERLLDFTQAQILQGLRKGVDVQRFTADDQYKRETILGLAETLEESVYSIAISLAQRYSVSRWEVFMTHLEFLFTDSGLS TLEIENRAQDLHLFETLKTDPEAFHQHMVKYIYPTIGGFDHERLQYYFTLLENCGCADLGNCAIKPETHIRLLKKFKVVASGLNYKKLTD ENMSPLEALEPVLSSQNILSISKLVPKIPEKDGQMLSPSSLYTIWLQKLFWTGDPHLIKQVPGSSPEWLHAYDVCMKYFDRLHPGDLITV VDAVTFSPKAVTKLSVEARKEMTRKAIKTVKHFIEKPRKRNSEDEAQEAKDSKVTYADTLNHLEKSLAHLETLSHSFILSLKNSEQETLQ KYSHLYDLSRSEKEKLHDEAVAICLDGQPLAMIQQLLEVAVGPLDISPKDIVQSAIMKIISALSGGSADLGGPRDPLKVLEGVVAAVHAS VDKGEELVSPEDLLEWLRPFCADDAWPVRPRIHVLQILGQSFHLTEEDSKLLVFFRTEAILKASWPQRQVDIADIENEENRYCLFMELLE SSHHEAEFQHLVLLLQAWPPMKSEYVITNNPWVRLATVMLTRCTMENKEGLGNEVLKMCRSLYNTKQMLPAEGVKELCLLLLNQSLLLPS LKLLLESRDEHLHEMALEQITAVTTVNDSNCDQELLSLLLDAKLLVKCVSTPFYPRIVDHLLASLQQGRWDAEELGRHLREAGHEAEAGS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for BIRC6-NBAS |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | NBAS | chr2:32774548 | chr2:15679480 | ENST00000281513 | 5 | 52 | 1036_2371 | 126.33333333333333 | 2372.0 | ZW10 and RINT1 | |
| Tgene | NBAS | chr2:32774548 | chr2:15679480 | ENST00000441750 | 5 | 50 | 1036_2371 | 126.33333333333333 | 2252.0 | ZW10 and RINT1 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | NBAS | chr2:32774548 | chr2:15679480 | ENST00000281513 | 5 | 52 | 1_1035 | 126.33333333333333 | 2372.0 | USE1L | |
| Tgene | NBAS | chr2:32774548 | chr2:15679480 | ENST00000441750 | 5 | 50 | 1_1035 | 126.33333333333333 | 2252.0 | USE1L |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for BIRC6-NBAS |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for BIRC6-NBAS |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | BIRC6 | C0006826 | Malignant Neoplasms | 1 | CTD_human |
| Hgene | BIRC6 | C0027651 | Neoplasms | 1 | CTD_human |
| Hgene | BIRC6 | C0086692 | Benign Neoplasm | 1 | CTD_human |
| Tgene | C3541319 | SHORT STATURE, OPTIC NERVE ATROPHY, AND PELGER-HUET ANOMALY | 2 | GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
| Tgene | C0021051 | Immunologic Deficiency Syndromes | 1 | GENOMICS_ENGLAND | |
| Tgene | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human | |
| Tgene | C0038356 | Stomach Neoplasms | 1 | CTD_human | |
| Tgene | C0235874 | Disease Exacerbation | 1 | CTD_human | |
| Tgene | C0424605 | Developmental delay (disorder) | 1 | GENOMICS_ENGLAND | |
| Tgene | C0557874 | Global developmental delay | 1 | GENOMICS_ENGLAND | |
| Tgene | C1390474 | Increased susceptibility to fractures | 1 | GENOMICS_ENGLAND | |
| Tgene | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human | |
| Tgene | C3809651 | INFANTILE LIVER FAILURE SYNDROME 2 | 1 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
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