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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RB1-HTR2C (FusionGDB2 ID:HG5925TG3358)

Fusion Gene Summary for RB1-HTR2C

check button Fusion gene summary
Fusion gene informationFusion gene name: RB1-HTR2C
Fusion gene ID: hg5925tg3358
HgeneTgene
Gene symbol

RB1

HTR2C

Gene ID

5925

3358

Gene nameRB transcriptional corepressor 15-hydroxytryptamine receptor 2C
SynonymsOSRC|PPP1R130|RB|p105-Rb|p110-RB1|pRb|pp1105-HT1C|5-HT2C|5-HTR2C|5HTR2C|HTR1C
Cytomap('RB1')('HTR2C')

13q14.2

Xq23

Type of geneprotein-codingprotein-coding
Descriptionretinoblastoma-associated proteinGOS563 exon 17 substitution mutation causes premature stopexon 17 tumor GOS561 substitution mutation causes premature stopprepro-retinoblastoma-associated proteinprotein phosphatase 1, regulatory subunit 130retinoblas5-hydroxytryptamine receptor 2C5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled5-hydroxytryptamine receptor 1Cserotonin 5-HT-1C receptorserotonin 5-HT-2C receptor
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000267163, ENST00000484879, 
Fusion gene scores* DoF score23 X 9 X 13=26913 X 4 X 2=24
# samples 274
** MAII scorelog2(27/2691*10)=-3.31711107858959
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RB1 [Title/Abstract] AND HTR2C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRB1(48881542)-HTR2C(114141152), # samples:3
Anticipated loss of major functional domain due to fusion event.RB1-HTR2C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RB1-HTR2C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RB1-HTR2C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RB1-HTR2C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RB1-HTR2C seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
RB1-HTR2C seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
RB1-HTR2C seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
RB1-HTR2C seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRB1

GO:0043550

regulation of lipid kinase activity

16286473

HgeneRB1

GO:0045892

negative regulation of transcription, DNA-templated

10783144|12065415|19223331

HgeneRB1

GO:2000679

positive regulation of transcription regulatory region DNA binding

25100735

TgeneHTR2C

GO:0006874

cellular calcium ion homeostasis

19057895

TgeneHTR2C

GO:0007200

phospholipase C-activating G protein-coupled receptor signaling pathway

12970106

TgeneHTR2C

GO:0010513

positive regulation of phosphatidylinositol biosynthetic process

19057895

TgeneHTR2C

GO:0019934

cGMP-mediated signaling

12970106

TgeneHTR2C

GO:0042493

response to drug

18703043

TgeneHTR2C

GO:0070374

positive regulation of ERK1 and ERK2 cascade

19057895


check buttonFusion gene breakpoints across RB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across HTR2C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-D6-6827-01ARB1chr13

48881542

-HTR2CchrX

114141152

+
ChimerDB4HNSCTCGA-D6-6827-01ARB1chr13

48881542

+HTR2CchrX

114141152

+
ChimerDB4HNSCTCGA-D6-6827RB1chr13

48881542

+HTR2CchrX

114141151

+
ChimerDB4HNSCTCGA-D6-6827RB1chr13

48881542

+HTR2CchrX

114141152

+


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Fusion Gene ORF analysis for RB1-HTR2C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000267163ENST00000371950RB1chr13

48881542

+HTR2CchrX

114141152

+
Frame-shiftENST00000267163ENST00000371950RB1chr13

48881542

+HTR2CchrX

114141151

+
In-frameENST00000267163ENST00000276198RB1chr13

48881542

+HTR2CchrX

114141152

+
In-frameENST00000267163ENST00000276198RB1chr13

48881542

+HTR2CchrX

114141151

+
In-frameENST00000267163ENST00000371951RB1chr13

48881542

+HTR2CchrX

114141152

+
In-frameENST00000267163ENST00000371951RB1chr13

48881542

+HTR2CchrX

114141151

+
intron-3CDSENST00000484879ENST00000276198RB1chr13

48881542

+HTR2CchrX

114141152

+
intron-3CDSENST00000484879ENST00000276198RB1chr13

48881542

+HTR2CchrX

114141151

+
intron-3CDSENST00000484879ENST00000371950RB1chr13

48881542

+HTR2CchrX

114141152

+
intron-3CDSENST00000484879ENST00000371950RB1chr13

48881542

+HTR2CchrX

114141151

+
intron-3CDSENST00000484879ENST00000371951RB1chr13

48881542

+HTR2CchrX

114141152

+
intron-3CDSENST00000484879ENST00000371951RB1chr13

48881542

+HTR2CchrX

114141151

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000267163RB1chr1348881542+ENST00000371951HTR2CchrX114141152+23214023171228303
ENST00000267163RB1chr1348881542+ENST00000276198HTR2CchrX114141152+38754023171228303
ENST00000267163RB1chr1348881542+ENST00000371951HTR2CchrX114141151+23214023171228303
ENST00000267163RB1chr1348881542+ENST00000276198HTR2CchrX114141151+38754023171228303

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000267163ENST00000371951RB1chr1348881542+HTR2CchrX114141152+0.0005446550.9994554
ENST00000267163ENST00000276198RB1chr1348881542+HTR2CchrX114141152+0.0003281170.99967194
ENST00000267163ENST00000371951RB1chr1348881542+HTR2CchrX114141151+0.0005446550.9994554
ENST00000267163ENST00000276198RB1chr1348881542+HTR2CchrX114141151+0.0003281170.99967194

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Fusion Genomic Features for RB1-HTR2C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RB1chr1348881542+HTR2CchrX114141151+1.64E-070.9999999
RB1chr1348881542+HTR2CchrX114141151+1.64E-070.9999999
RB1chr1348881542+HTR2CchrX114141151+1.64E-070.9999999
RB1chr1348881542+HTR2CchrX114141151+1.64E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for RB1-HTR2C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:48881542/chrX:114141152)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRB1chr13:48881542chrX:114141151ENST00000267163+22710_1888929.0Compositional biasNote=Poly-Ala
HgeneRB1chr13:48881542chrX:114141151ENST00000267163+22720_2988929.0Compositional biasNote=Poly-Pro
HgeneRB1chr13:48881542chrX:114141152ENST00000267163+22710_1888929.0Compositional biasNote=Poly-Ala
HgeneRB1chr13:48881542chrX:114141152ENST00000267163+22720_2988929.0Compositional biasNote=Poly-Pro
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846364_368183459.0MotifNPxxY motif%3B important for ligand-induced conformation changes and signaling
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846456_458183459.0MotifNote=PDZ-binding
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046151_153151249.0MotifDRY motif%3B important for ligand-induced conformation changes
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046364_368151249.0MotifNPxxY motif%3B important for ligand-induced conformation changes and signaling
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046456_458151249.0MotifNote=PDZ-binding
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157364_368183459.0MotifNPxxY motif%3B important for ligand-induced conformation changes and signaling
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157456_458183459.0MotifNote=PDZ-binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846364_368183459.0MotifNPxxY motif%3B important for ligand-induced conformation changes and signaling
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846456_458183459.0MotifNote=PDZ-binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046151_153151249.0MotifDRY motif%3B important for ligand-induced conformation changes
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046364_368151249.0MotifNPxxY motif%3B important for ligand-induced conformation changes and signaling
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046456_458151249.0MotifNote=PDZ-binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157364_368183459.0MotifNPxxY motif%3B important for ligand-induced conformation changes and signaling
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157456_458183459.0MotifNote=PDZ-binding
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846324_328183459.0RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046324_328151249.0RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157324_328183459.0RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846324_328183459.0RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046324_328151249.0RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157324_328183459.0RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846194_213183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846236_311183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846334_348183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846372_458183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046151_170151249.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046194_213151249.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046236_311151249.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046334_348151249.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046372_458151249.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157194_213183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157236_311183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157334_348183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157372_458183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846194_213183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846236_311183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846334_348183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846372_458183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046151_170151249.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046194_213151249.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046236_311151249.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046334_348151249.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046372_458151249.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157194_213183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157236_311183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157334_348183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157372_458183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846214_235183459.0TransmembraneHelical%3B Name%3D5
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846312_333183459.0TransmembraneHelical%3B Name%3D6
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846349_371183459.0TransmembraneHelical%3B Name%3D7
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046171_193151249.0TransmembraneHelical%3B Name%3D4
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046214_235151249.0TransmembraneHelical%3B Name%3D5
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046312_333151249.0TransmembraneHelical%3B Name%3D6
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046349_371151249.0TransmembraneHelical%3B Name%3D7
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157214_235183459.0TransmembraneHelical%3B Name%3D5
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157312_333183459.0TransmembraneHelical%3B Name%3D6
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157349_371183459.0TransmembraneHelical%3B Name%3D7
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846214_235183459.0TransmembraneHelical%3B Name%3D5
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846312_333183459.0TransmembraneHelical%3B Name%3D6
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846349_371183459.0TransmembraneHelical%3B Name%3D7
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046171_193151249.0TransmembraneHelical%3B Name%3D4
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046214_235151249.0TransmembraneHelical%3B Name%3D5
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046312_333151249.0TransmembraneHelical%3B Name%3D6
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046349_371151249.0TransmembraneHelical%3B Name%3D7
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157214_235183459.0TransmembraneHelical%3B Name%3D5
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157312_333183459.0TransmembraneHelical%3B Name%3D6
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157349_371183459.0TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRB1chr13:48881542chrX:114141151ENST00000267163+227860_87688929.0MotifBipartite nuclear localization signal
HgeneRB1chr13:48881542chrX:114141152ENST00000267163+227860_87688929.0MotifBipartite nuclear localization signal
HgeneRB1chr13:48881542chrX:114141151ENST00000267163+227373_57988929.0RegionNote=Domain A
HgeneRB1chr13:48881542chrX:114141151ENST00000267163+227373_77188929.0RegionNote=Pocket%3B binds T and E1A
HgeneRB1chr13:48881542chrX:114141151ENST00000267163+227580_63988929.0RegionNote=Spacer
HgeneRB1chr13:48881542chrX:114141151ENST00000267163+227640_77188929.0RegionNote=Domain B
HgeneRB1chr13:48881542chrX:114141152ENST00000267163+227373_57988929.0RegionNote=Domain A
HgeneRB1chr13:48881542chrX:114141152ENST00000267163+227373_77188929.0RegionNote=Pocket%3B binds T and E1A
HgeneRB1chr13:48881542chrX:114141152ENST00000267163+227580_63988929.0RegionNote=Spacer
HgeneRB1chr13:48881542chrX:114141152ENST00000267163+227640_77188929.0RegionNote=Domain B
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846151_153183459.0MotifDRY motif%3B important for ligand-induced conformation changes
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157151_153183459.0MotifDRY motif%3B important for ligand-induced conformation changes
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846151_153183459.0MotifDRY motif%3B important for ligand-induced conformation changes
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157151_153183459.0MotifDRY motif%3B important for ligand-induced conformation changes
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846134_139183459.0RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046134_139151249.0RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157134_139183459.0RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846134_139183459.0RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046134_139151249.0RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157134_139183459.0RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846111_127183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846151_170183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141151ENST000002761984633_52183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141151ENST000002761984679_89183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046111_127151249.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141151ENST000003719504633_52151249.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141151ENST000003719504679_89151249.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157111_127183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157151_170183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141151ENST000003719515733_52183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141151ENST000003719515779_89183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846111_127183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846151_170183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST000002761984633_52183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST000002761984679_89183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046111_127151249.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST000003719504633_52151249.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST000003719504679_89151249.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157111_127183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157151_170183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST000003719515733_52183459.0Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST000003719515779_89183459.0Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846128_150183459.0TransmembraneHelical%3B Name%3D3
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000027619846171_193183459.0TransmembraneHelical%3B Name%3D4
TgeneHTR2Cchr13:48881542chrX:114141151ENST000002761984653_78183459.0TransmembraneHelical%3B Name%3D1
TgeneHTR2Cchr13:48881542chrX:114141151ENST000002761984690_110183459.0TransmembraneHelical%3B Name%3D2
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195046128_150151249.0TransmembraneHelical%3B Name%3D3
TgeneHTR2Cchr13:48881542chrX:114141151ENST000003719504653_78151249.0TransmembraneHelical%3B Name%3D1
TgeneHTR2Cchr13:48881542chrX:114141151ENST000003719504690_110151249.0TransmembraneHelical%3B Name%3D2
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157128_150183459.0TransmembraneHelical%3B Name%3D3
TgeneHTR2Cchr13:48881542chrX:114141151ENST0000037195157171_193183459.0TransmembraneHelical%3B Name%3D4
TgeneHTR2Cchr13:48881542chrX:114141151ENST000003719515753_78183459.0TransmembraneHelical%3B Name%3D1
TgeneHTR2Cchr13:48881542chrX:114141151ENST000003719515790_110183459.0TransmembraneHelical%3B Name%3D2
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846128_150183459.0TransmembraneHelical%3B Name%3D3
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000027619846171_193183459.0TransmembraneHelical%3B Name%3D4
TgeneHTR2Cchr13:48881542chrX:114141152ENST000002761984653_78183459.0TransmembraneHelical%3B Name%3D1
TgeneHTR2Cchr13:48881542chrX:114141152ENST000002761984690_110183459.0TransmembraneHelical%3B Name%3D2
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195046128_150151249.0TransmembraneHelical%3B Name%3D3
TgeneHTR2Cchr13:48881542chrX:114141152ENST000003719504653_78151249.0TransmembraneHelical%3B Name%3D1
TgeneHTR2Cchr13:48881542chrX:114141152ENST000003719504690_110151249.0TransmembraneHelical%3B Name%3D2
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157128_150183459.0TransmembraneHelical%3B Name%3D3
TgeneHTR2Cchr13:48881542chrX:114141152ENST0000037195157171_193183459.0TransmembraneHelical%3B Name%3D4
TgeneHTR2Cchr13:48881542chrX:114141152ENST000003719515753_78183459.0TransmembraneHelical%3B Name%3D1
TgeneHTR2Cchr13:48881542chrX:114141152ENST000003719515790_110183459.0TransmembraneHelical%3B Name%3D2


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Fusion Gene Sequence for RB1-HTR2C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>72563_72563_1_RB1-HTR2C_RB1_chr13_48881542_ENST00000267163_HTR2C_chrX_114141151_ENST00000276198_length(transcript)=3875nt_BP=402nt
TCCGGTTTTTCTCAGGGGACGTTGAAATTATTTTTGTAACGGGAGTCGGGAGAGGACGGGGCGTGCCCCGACGTGCGCGCGCGTCGTCCT
CCCCGGCGCTCCTCCACAGCTCGCTGGCTCCCGCCGCGGAAAGGCGTCATGCCGCCCAAAACCCCCCGAAAAACGGCCGCCACCGCCGCC
GCTGCCGCCGCGGAACCCCCGGCACCGCCGCCGCCGCCCCCTCCTGAGGAGGACCCAGAGCAGGACAGCGGCCCGGAGGACCTGCCTCTC
GTCAGGCTTGAGTTTGAAGAAACAGAAGAACCTGATTTTACTGCATTATGTCAGAAATTAAAGATACCAGATCATGTCAGAGAGAGAGCT
TGGTTAACTTGGGAGAAAGTTTCATCTGTGGATGGAGTATTGGTGTATCAGTTCCTATCCCTGTGATTGGACTGAGGGACGAAGAAAAGG
TGTTCGTGAACAACACGACGTGCGTGCTCAACGACCCAAATTTCGTTCTTATTGGGTCCTTCGTAGCTTTCTTCATACCGCTGACGATTA
TGGTGATTACGTATTGCCTGACCATCTACGTTCTGCGCCGACAAGCTTTGATGTTACTGCACGGCCACACCGAGGAACCGCCTGGACTAA
GTCTGGATTTCCTGAAGTGCTGCAAGAGGAATACGGCCGAGGAAGAGAACTCTGCAAACCCTAACCAAGACCAGAACGCACGCCGAAGAA
AGAAGAAGGAGAGACGTCCTAGGGGCACCATGCAGGCTATCAACAATGAAAGAAAAGCTTCGAAAGTCCTTGGGATTGTTTTCTTTGTGT
TTCTGATCATGTGGTGCCCATTTTTCATTACCAATATTCTGTCTGTTCTTTGTGAGAAGTCCTGTAACCAAAAGCTCATGGAAAAGCTTC
TGAATGTGTTTGTTTGGATTGGCTATGTTTGTTCAGGAATCAATCCTCTGGTGTATACTCTGTTCAACAAAATTTACCGAAGGGCATTCT
CCAACTATTTGCGTTGCAATTATAAGGTAGAGAAAAAGCCTCCTGTCAGGCAGATTCCAAGAGTTGCCGCCACTGCTTTGTCTGGGAGGG
AGCTTAATGTTAACATTTATCGGCATACCAATGAACCGGTGATCGAGAAAGCCAGTGACAATGAGCCCGGTATAGAGATGCAAGTTGAGA
ATTTAGAGTTACCAGTAAATCCCTCCAGTGTGGTTAGCGAAAGGATTAGCAGTGTGTGAGAAAGAACAGCACAGTCTTTTCCTACGGTAC
AAGCTACATATGTAGGAAAATTTTCTTCTTTAATTTTTCTGTTGGTCTTAACTAATGTAAATATTGCTGTCTGAAAAAGTGTTTTTACAT
ATAGCTTTGCAACCTTGTACTTTACAATCATGCCTACATTAGTGAGATTTAGGGTTCTATATTTACTGTTTATAATAGGTGGAGACTAAC
TTATTTTGATTGTTTGATGAATAAAATGTTTATTTTTGCTCTCCCTCCCTTCTTTCCTTCCTTTTTTCCTTTCTTCCTTCCTTTCTCTCT
TTCTTTTGTGCATATGGCAACGTTCATGTTCATCTCAGGTGGCATTTGCAGGTGACCAGAATGAGGCACATGACAGTGGTTATATTTCAA
CCACACCTAAATTAACAAATTCAGTGGACATTTGTTCTGGGTTAACAGTAAATATACACTTTACATTCTTGCTCTGCTCATCTACACATA
TAAACACAGTAAGATAGGTTCTGCTTTCTGATACATCTGTCAGTGAGTCAGAGGCAGAACCTAGTCTTGTTGTTCATATAGGGGCAAAAA
TTTGACATTGTCAGAATGTTGTGTTGGTATTTACTGCAATGTCTGTCCCTAAACATAGTGGTATTTTAACATAGCAGCTGGTTAACCGGG
ACTACAGAAGTGGAAGGATAATGAGATGTAATACACCAAATAGCTTTTCACTTCTTAAGGACAGTGTTCAAATTCTGATTATTACAACAA
GCAAACTGAAATTAGTGTTTTCATTCTGGTCCTTAGTAAATTCCTAATTCTATGATTAAACTGGGAAATGAGATCCCAGAGTTATTTCCC
AACCCAGGATTCAACATCAATTGGGTTTTGATCTCAGCATCCTGGAAATTTGTGTGCTTCACACAAAGTGAAATTAGTATTTTGAGCCTT
ATTAAAATATTTTCTTAATTATGGTACCTCTGTCTATAGGACTTAATTTAGCAGTCCATTTTTGAGTAAAACTTGTATTGGAAGTATAGA
TGGTAGAAACTTTGGAAGTTTTACTTGATTAAGGACTACAGAATTGGGCCCTTAGAATGTGAAAAAAAAAAGTAATTAAAAAGACACTTT
TACCGAACTCGGGATTACAGAAACACGGAGTTTCCATTTGGATTTTAAACAAAATTTATGTCATTTTCAGATCCTTCCAAACTCTCTAGT
GCAGGAAAAGGCTGCAGCTAATTTGTGAAAGTGGCAAGCTCTTCATTGCACTGCAGTTATTTACCAGAAGTTTAAATCTTTGTTAAAATA
TAGTGTTGTGTTACAATAAGTGTTGGCCATCATTTCATTCGTGGGCCTGCTGCTCTCTAAGAATTCAGTAGCATTTTAATAGTTTCTAAA
CCATGAAAAGTTTTCAAGCATTGCTAAAGTCAGGCCATTCAGTCTATGCTGTGTGCAGAGTATACAAGTGTTTCTAGTAACAGTATTTCC
ATACGTGCCCATTTCACACAACTGTGGATAAATTTTGGAAGAATTCATGATGCTAGTTCTTACGCTTGACAGTTACTTACACACCTGAGA
ATGTGCCTCTCAGTATCTTAAAATTGGTTAATGAAAAATCTGAATTTCTAAAACCCTTGGTCTGTGTTCTCAACACACAGTATAGATAAA
TCCAATAGTCTGCCACAAGGGCAGTGGAAGAGCTGCTGTATTTGAGGAAACTCATACAGTCTCTATTTGATTTGCAACACTGCCAAACAT
CAGTCAATTGCTTGAGCATGCCCAAATATAACATGAAAGTCAAGTCTACCTGCCTTGCCTGTTAGGTCTGTTGAAGTGCATGTTAAAATA
ATTATATGAAGCAGAATGAGATGATTTAATTCTTACCGAAATGAAAATGGCTGAAGAAACACAGCATGCATTTAGCATGAGTTCTGCACA
TACAGATGGTGTCCTGCATGTATGCCATGTATGTTGCATGAATCCATCGATTTGTATTAATGTAGGGCAGAATAGCTGATAGAAGAAGGA
CTGAAGAAAATCCTTCAGCAATCCTTAAAAAGACCATGCATTCAGATCTGAAGTAGTGTGAGTGTTAGAAAAAACTGGAAACATCTGATT
TCTGAACTATCAGGGCAAGCTCATAGCACATGTTTTACAAAGAAACAAAATATAAATCACAGATTTCCAAAAGTACTAGCAATAAGTTGA
ATGATAATAGCTCACAGCACATTTGTTAATGATTCTTGTGTCATCAAGTAGTAGTACTTAATAGTACCCAACCTGGTAATTATCCTCAAG
TTGTGTGCTATTCGTAAGTTCTGTGCAGTTTGGTATGAAACAAATATACTCATTTGGATATAAATCTTACCCTTCAATGTTAAATCTACA
AACTTTTATAAATGTTTTAAAGAAGTCCATGTGATAATTGTAAAGGTGATGAATTTACCATCAAACAAATCATTTTGATGTATTATTATA
TATGTATATCTGTGTAAGACACGTGCAACAGACTGCCTTATATTATTTTCTGTAATTCTTCTCCTTTGTCAAATGGTATTTTTTGTGAAT
GGTTGCAAAGTGTTGTCTTATTCCTAATTCCTGTATGTTATCCACTACAGGTTTTATGAGACTTCCTATTAATTTATTAAATTTATTAAA

>72563_72563_1_RB1-HTR2C_RB1_chr13_48881542_ENST00000267163_HTR2C_chrX_114141151_ENST00000276198_length(amino acids)=303AA_BP=28
MSEIKDTRSCQRESLVNLGESFICGWSIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQA
LMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSV
LCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIE

--------------------------------------------------------------
>72563_72563_2_RB1-HTR2C_RB1_chr13_48881542_ENST00000267163_HTR2C_chrX_114141151_ENST00000371951_length(transcript)=2321nt_BP=402nt
TCCGGTTTTTCTCAGGGGACGTTGAAATTATTTTTGTAACGGGAGTCGGGAGAGGACGGGGCGTGCCCCGACGTGCGCGCGCGTCGTCCT
CCCCGGCGCTCCTCCACAGCTCGCTGGCTCCCGCCGCGGAAAGGCGTCATGCCGCCCAAAACCCCCCGAAAAACGGCCGCCACCGCCGCC
GCTGCCGCCGCGGAACCCCCGGCACCGCCGCCGCCGCCCCCTCCTGAGGAGGACCCAGAGCAGGACAGCGGCCCGGAGGACCTGCCTCTC
GTCAGGCTTGAGTTTGAAGAAACAGAAGAACCTGATTTTACTGCATTATGTCAGAAATTAAAGATACCAGATCATGTCAGAGAGAGAGCT
TGGTTAACTTGGGAGAAAGTTTCATCTGTGGATGGAGTATTGGTGTATCAGTTCCTATCCCTGTGATTGGACTGAGGGACGAAGAAAAGG
TGTTCGTGAACAACACGACGTGCGTGCTCAACGACCCAAATTTCGTTCTTATTGGGTCCTTCGTAGCTTTCTTCATACCGCTGACGATTA
TGGTGATTACGTATTGCCTGACCATCTACGTTCTGCGCCGACAAGCTTTGATGTTACTGCACGGCCACACCGAGGAACCGCCTGGACTAA
GTCTGGATTTCCTGAAGTGCTGCAAGAGGAATACGGCCGAGGAAGAGAACTCTGCAAACCCTAACCAAGACCAGAACGCACGCCGAAGAA
AGAAGAAGGAGAGACGTCCTAGGGGCACCATGCAGGCTATCAACAATGAAAGAAAAGCTTCGAAAGTCCTTGGGATTGTTTTCTTTGTGT
TTCTGATCATGTGGTGCCCATTTTTCATTACCAATATTCTGTCTGTTCTTTGTGAGAAGTCCTGTAACCAAAAGCTCATGGAAAAGCTTC
TGAATGTGTTTGTTTGGATTGGCTATGTTTGTTCAGGAATCAATCCTCTGGTGTATACTCTGTTCAACAAAATTTACCGAAGGGCATTCT
CCAACTATTTGCGTTGCAATTATAAGGTAGAGAAAAAGCCTCCTGTCAGGCAGATTCCAAGAGTTGCCGCCACTGCTTTGTCTGGGAGGG
AGCTTAATGTTAACATTTATCGGCATACCAATGAACCGGTGATCGAGAAAGCCAGTGACAATGAGCCCGGTATAGAGATGCAAGTTGAGA
ATTTAGAGTTACCAGTAAATCCCTCCAGTGTGGTTAGCGAAAGGATTAGCAGTGTGTGAGAAAGAACAGCACAGTCTTTTCCTACGGTAC
AAGCTACATATGTAGGAAAATTTTCTTCTTTAATTTTTCTGTTGGTCTTAACTAATGTAAATATTGCTGTCTGAAAAAGTGTTTTTACAT
ATAGCTTTGCAACCTTGTACTTTACAATCATGCCTACATTAGTGAGATTTAGGGTTCTATATTTACTGTTTATAATAGGTGGAGACTAAC
TTATTTTGATTGTTTGATGAATAAAATGTTTATTTTTGCTCTCCCTCCCTTCTTTCCTTCCTTTTTTCCTTTCTTCCTTCCTTTCTCTCT
TTCTTTTGTGCATATGGCAACGTTCATGTTCATCTCAGGTGGCATTTGCAGGTGACCAGAATGAGGCACATGACAGTGGTTATATTTCAA
CCACACCTAAATTAACAAATTCAGTGGACATTTGTTCTGGGTTAACAGTAAATATACACTTTACATTCTTGCTCTGCTCATCTACACATA
TAAACACAGTAAGATAGGTTCTGCTTTCTGATACATCTGTCAGTGAGTCAGAGGCAGAACCTAGTCTTGTTGTTCATATAGGGGCAAAAA
TTTGACATTGTCAGAATGTTGTGTTGGTATTTACTGCAATGTCTGTCCCTAAACATAGTGGTATTTTAACATAGCAGCTGGTTAACCGGG
ACTACAGAAGTGGAAGGATAATGAGATGTAATACACCAAATAGCTTTTCACTTCTTAAGGACAGTGTTCAAATTCTGATTATTACAACAA
GCAAACTGAAATTAGTGTTTTCATTCTGGTCCTTAGTAAATTCCTAATTCTATGATTAAACTGGGAAATGAGATCCCAGAGTTATTTCCC
AACCCAGGATTCAACATCAATTGGGTTTTGATCTCAGCATCCTGGAAATTTGTGTGCTTCACACAAAGTGAAATTAGTATTTTGAGCCTT
ATTAAAATATTTTCTTAATTATGGTACCTCTGTCTATAGGACTTAATTTAGCAGTCCATTTTTGAGTAAAACTTGTATTGGAAGTATAGA

>72563_72563_2_RB1-HTR2C_RB1_chr13_48881542_ENST00000267163_HTR2C_chrX_114141151_ENST00000371951_length(amino acids)=303AA_BP=28
MSEIKDTRSCQRESLVNLGESFICGWSIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQA
LMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSV
LCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIE

--------------------------------------------------------------
>72563_72563_3_RB1-HTR2C_RB1_chr13_48881542_ENST00000267163_HTR2C_chrX_114141152_ENST00000276198_length(transcript)=3875nt_BP=402nt
TCCGGTTTTTCTCAGGGGACGTTGAAATTATTTTTGTAACGGGAGTCGGGAGAGGACGGGGCGTGCCCCGACGTGCGCGCGCGTCGTCCT
CCCCGGCGCTCCTCCACAGCTCGCTGGCTCCCGCCGCGGAAAGGCGTCATGCCGCCCAAAACCCCCCGAAAAACGGCCGCCACCGCCGCC
GCTGCCGCCGCGGAACCCCCGGCACCGCCGCCGCCGCCCCCTCCTGAGGAGGACCCAGAGCAGGACAGCGGCCCGGAGGACCTGCCTCTC
GTCAGGCTTGAGTTTGAAGAAACAGAAGAACCTGATTTTACTGCATTATGTCAGAAATTAAAGATACCAGATCATGTCAGAGAGAGAGCT
TGGTTAACTTGGGAGAAAGTTTCATCTGTGGATGGAGTATTGGTGTATCAGTTCCTATCCCTGTGATTGGACTGAGGGACGAAGAAAAGG
TGTTCGTGAACAACACGACGTGCGTGCTCAACGACCCAAATTTCGTTCTTATTGGGTCCTTCGTAGCTTTCTTCATACCGCTGACGATTA
TGGTGATTACGTATTGCCTGACCATCTACGTTCTGCGCCGACAAGCTTTGATGTTACTGCACGGCCACACCGAGGAACCGCCTGGACTAA
GTCTGGATTTCCTGAAGTGCTGCAAGAGGAATACGGCCGAGGAAGAGAACTCTGCAAACCCTAACCAAGACCAGAACGCACGCCGAAGAA
AGAAGAAGGAGAGACGTCCTAGGGGCACCATGCAGGCTATCAACAATGAAAGAAAAGCTTCGAAAGTCCTTGGGATTGTTTTCTTTGTGT
TTCTGATCATGTGGTGCCCATTTTTCATTACCAATATTCTGTCTGTTCTTTGTGAGAAGTCCTGTAACCAAAAGCTCATGGAAAAGCTTC
TGAATGTGTTTGTTTGGATTGGCTATGTTTGTTCAGGAATCAATCCTCTGGTGTATACTCTGTTCAACAAAATTTACCGAAGGGCATTCT
CCAACTATTTGCGTTGCAATTATAAGGTAGAGAAAAAGCCTCCTGTCAGGCAGATTCCAAGAGTTGCCGCCACTGCTTTGTCTGGGAGGG
AGCTTAATGTTAACATTTATCGGCATACCAATGAACCGGTGATCGAGAAAGCCAGTGACAATGAGCCCGGTATAGAGATGCAAGTTGAGA
ATTTAGAGTTACCAGTAAATCCCTCCAGTGTGGTTAGCGAAAGGATTAGCAGTGTGTGAGAAAGAACAGCACAGTCTTTTCCTACGGTAC
AAGCTACATATGTAGGAAAATTTTCTTCTTTAATTTTTCTGTTGGTCTTAACTAATGTAAATATTGCTGTCTGAAAAAGTGTTTTTACAT
ATAGCTTTGCAACCTTGTACTTTACAATCATGCCTACATTAGTGAGATTTAGGGTTCTATATTTACTGTTTATAATAGGTGGAGACTAAC
TTATTTTGATTGTTTGATGAATAAAATGTTTATTTTTGCTCTCCCTCCCTTCTTTCCTTCCTTTTTTCCTTTCTTCCTTCCTTTCTCTCT
TTCTTTTGTGCATATGGCAACGTTCATGTTCATCTCAGGTGGCATTTGCAGGTGACCAGAATGAGGCACATGACAGTGGTTATATTTCAA
CCACACCTAAATTAACAAATTCAGTGGACATTTGTTCTGGGTTAACAGTAAATATACACTTTACATTCTTGCTCTGCTCATCTACACATA
TAAACACAGTAAGATAGGTTCTGCTTTCTGATACATCTGTCAGTGAGTCAGAGGCAGAACCTAGTCTTGTTGTTCATATAGGGGCAAAAA
TTTGACATTGTCAGAATGTTGTGTTGGTATTTACTGCAATGTCTGTCCCTAAACATAGTGGTATTTTAACATAGCAGCTGGTTAACCGGG
ACTACAGAAGTGGAAGGATAATGAGATGTAATACACCAAATAGCTTTTCACTTCTTAAGGACAGTGTTCAAATTCTGATTATTACAACAA
GCAAACTGAAATTAGTGTTTTCATTCTGGTCCTTAGTAAATTCCTAATTCTATGATTAAACTGGGAAATGAGATCCCAGAGTTATTTCCC
AACCCAGGATTCAACATCAATTGGGTTTTGATCTCAGCATCCTGGAAATTTGTGTGCTTCACACAAAGTGAAATTAGTATTTTGAGCCTT
ATTAAAATATTTTCTTAATTATGGTACCTCTGTCTATAGGACTTAATTTAGCAGTCCATTTTTGAGTAAAACTTGTATTGGAAGTATAGA
TGGTAGAAACTTTGGAAGTTTTACTTGATTAAGGACTACAGAATTGGGCCCTTAGAATGTGAAAAAAAAAAGTAATTAAAAAGACACTTT
TACCGAACTCGGGATTACAGAAACACGGAGTTTCCATTTGGATTTTAAACAAAATTTATGTCATTTTCAGATCCTTCCAAACTCTCTAGT
GCAGGAAAAGGCTGCAGCTAATTTGTGAAAGTGGCAAGCTCTTCATTGCACTGCAGTTATTTACCAGAAGTTTAAATCTTTGTTAAAATA
TAGTGTTGTGTTACAATAAGTGTTGGCCATCATTTCATTCGTGGGCCTGCTGCTCTCTAAGAATTCAGTAGCATTTTAATAGTTTCTAAA
CCATGAAAAGTTTTCAAGCATTGCTAAAGTCAGGCCATTCAGTCTATGCTGTGTGCAGAGTATACAAGTGTTTCTAGTAACAGTATTTCC
ATACGTGCCCATTTCACACAACTGTGGATAAATTTTGGAAGAATTCATGATGCTAGTTCTTACGCTTGACAGTTACTTACACACCTGAGA
ATGTGCCTCTCAGTATCTTAAAATTGGTTAATGAAAAATCTGAATTTCTAAAACCCTTGGTCTGTGTTCTCAACACACAGTATAGATAAA
TCCAATAGTCTGCCACAAGGGCAGTGGAAGAGCTGCTGTATTTGAGGAAACTCATACAGTCTCTATTTGATTTGCAACACTGCCAAACAT
CAGTCAATTGCTTGAGCATGCCCAAATATAACATGAAAGTCAAGTCTACCTGCCTTGCCTGTTAGGTCTGTTGAAGTGCATGTTAAAATA
ATTATATGAAGCAGAATGAGATGATTTAATTCTTACCGAAATGAAAATGGCTGAAGAAACACAGCATGCATTTAGCATGAGTTCTGCACA
TACAGATGGTGTCCTGCATGTATGCCATGTATGTTGCATGAATCCATCGATTTGTATTAATGTAGGGCAGAATAGCTGATAGAAGAAGGA
CTGAAGAAAATCCTTCAGCAATCCTTAAAAAGACCATGCATTCAGATCTGAAGTAGTGTGAGTGTTAGAAAAAACTGGAAACATCTGATT
TCTGAACTATCAGGGCAAGCTCATAGCACATGTTTTACAAAGAAACAAAATATAAATCACAGATTTCCAAAAGTACTAGCAATAAGTTGA
ATGATAATAGCTCACAGCACATTTGTTAATGATTCTTGTGTCATCAAGTAGTAGTACTTAATAGTACCCAACCTGGTAATTATCCTCAAG
TTGTGTGCTATTCGTAAGTTCTGTGCAGTTTGGTATGAAACAAATATACTCATTTGGATATAAATCTTACCCTTCAATGTTAAATCTACA
AACTTTTATAAATGTTTTAAAGAAGTCCATGTGATAATTGTAAAGGTGATGAATTTACCATCAAACAAATCATTTTGATGTATTATTATA
TATGTATATCTGTGTAAGACACGTGCAACAGACTGCCTTATATTATTTTCTGTAATTCTTCTCCTTTGTCAAATGGTATTTTTTGTGAAT
GGTTGCAAAGTGTTGTCTTATTCCTAATTCCTGTATGTTATCCACTACAGGTTTTATGAGACTTCCTATTAATTTATTAAATTTATTAAA

>72563_72563_3_RB1-HTR2C_RB1_chr13_48881542_ENST00000267163_HTR2C_chrX_114141152_ENST00000276198_length(amino acids)=303AA_BP=28
MSEIKDTRSCQRESLVNLGESFICGWSIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQA
LMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSV
LCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIE

--------------------------------------------------------------
>72563_72563_4_RB1-HTR2C_RB1_chr13_48881542_ENST00000267163_HTR2C_chrX_114141152_ENST00000371951_length(transcript)=2321nt_BP=402nt
TCCGGTTTTTCTCAGGGGACGTTGAAATTATTTTTGTAACGGGAGTCGGGAGAGGACGGGGCGTGCCCCGACGTGCGCGCGCGTCGTCCT
CCCCGGCGCTCCTCCACAGCTCGCTGGCTCCCGCCGCGGAAAGGCGTCATGCCGCCCAAAACCCCCCGAAAAACGGCCGCCACCGCCGCC
GCTGCCGCCGCGGAACCCCCGGCACCGCCGCCGCCGCCCCCTCCTGAGGAGGACCCAGAGCAGGACAGCGGCCCGGAGGACCTGCCTCTC
GTCAGGCTTGAGTTTGAAGAAACAGAAGAACCTGATTTTACTGCATTATGTCAGAAATTAAAGATACCAGATCATGTCAGAGAGAGAGCT
TGGTTAACTTGGGAGAAAGTTTCATCTGTGGATGGAGTATTGGTGTATCAGTTCCTATCCCTGTGATTGGACTGAGGGACGAAGAAAAGG
TGTTCGTGAACAACACGACGTGCGTGCTCAACGACCCAAATTTCGTTCTTATTGGGTCCTTCGTAGCTTTCTTCATACCGCTGACGATTA
TGGTGATTACGTATTGCCTGACCATCTACGTTCTGCGCCGACAAGCTTTGATGTTACTGCACGGCCACACCGAGGAACCGCCTGGACTAA
GTCTGGATTTCCTGAAGTGCTGCAAGAGGAATACGGCCGAGGAAGAGAACTCTGCAAACCCTAACCAAGACCAGAACGCACGCCGAAGAA
AGAAGAAGGAGAGACGTCCTAGGGGCACCATGCAGGCTATCAACAATGAAAGAAAAGCTTCGAAAGTCCTTGGGATTGTTTTCTTTGTGT
TTCTGATCATGTGGTGCCCATTTTTCATTACCAATATTCTGTCTGTTCTTTGTGAGAAGTCCTGTAACCAAAAGCTCATGGAAAAGCTTC
TGAATGTGTTTGTTTGGATTGGCTATGTTTGTTCAGGAATCAATCCTCTGGTGTATACTCTGTTCAACAAAATTTACCGAAGGGCATTCT
CCAACTATTTGCGTTGCAATTATAAGGTAGAGAAAAAGCCTCCTGTCAGGCAGATTCCAAGAGTTGCCGCCACTGCTTTGTCTGGGAGGG
AGCTTAATGTTAACATTTATCGGCATACCAATGAACCGGTGATCGAGAAAGCCAGTGACAATGAGCCCGGTATAGAGATGCAAGTTGAGA
ATTTAGAGTTACCAGTAAATCCCTCCAGTGTGGTTAGCGAAAGGATTAGCAGTGTGTGAGAAAGAACAGCACAGTCTTTTCCTACGGTAC
AAGCTACATATGTAGGAAAATTTTCTTCTTTAATTTTTCTGTTGGTCTTAACTAATGTAAATATTGCTGTCTGAAAAAGTGTTTTTACAT
ATAGCTTTGCAACCTTGTACTTTACAATCATGCCTACATTAGTGAGATTTAGGGTTCTATATTTACTGTTTATAATAGGTGGAGACTAAC
TTATTTTGATTGTTTGATGAATAAAATGTTTATTTTTGCTCTCCCTCCCTTCTTTCCTTCCTTTTTTCCTTTCTTCCTTCCTTTCTCTCT
TTCTTTTGTGCATATGGCAACGTTCATGTTCATCTCAGGTGGCATTTGCAGGTGACCAGAATGAGGCACATGACAGTGGTTATATTTCAA
CCACACCTAAATTAACAAATTCAGTGGACATTTGTTCTGGGTTAACAGTAAATATACACTTTACATTCTTGCTCTGCTCATCTACACATA
TAAACACAGTAAGATAGGTTCTGCTTTCTGATACATCTGTCAGTGAGTCAGAGGCAGAACCTAGTCTTGTTGTTCATATAGGGGCAAAAA
TTTGACATTGTCAGAATGTTGTGTTGGTATTTACTGCAATGTCTGTCCCTAAACATAGTGGTATTTTAACATAGCAGCTGGTTAACCGGG
ACTACAGAAGTGGAAGGATAATGAGATGTAATACACCAAATAGCTTTTCACTTCTTAAGGACAGTGTTCAAATTCTGATTATTACAACAA
GCAAACTGAAATTAGTGTTTTCATTCTGGTCCTTAGTAAATTCCTAATTCTATGATTAAACTGGGAAATGAGATCCCAGAGTTATTTCCC
AACCCAGGATTCAACATCAATTGGGTTTTGATCTCAGCATCCTGGAAATTTGTGTGCTTCACACAAAGTGAAATTAGTATTTTGAGCCTT
ATTAAAATATTTTCTTAATTATGGTACCTCTGTCTATAGGACTTAATTTAGCAGTCCATTTTTGAGTAAAACTTGTATTGGAAGTATAGA

>72563_72563_4_RB1-HTR2C_RB1_chr13_48881542_ENST00000267163_HTR2C_chrX_114141152_ENST00000371951_length(amino acids)=303AA_BP=28
MSEIKDTRSCQRESLVNLGESFICGWSIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQA
LMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSV
LCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIE

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Fusion Gene PPI Analysis for RB1-HTR2C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRB1chr13:48881542chrX:114141151ENST00000267163+227763_92888.0929.0LIMD1
HgeneRB1chr13:48881542chrX:114141152ENST00000267163+227763_92888.0929.0LIMD1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RB1-HTR2C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RB1-HTR2C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRB1C0035335Retinoblastoma15CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneRB1C0006142Malignant neoplasm of breast3CGI;CTD_human
HgeneRB1C0149925Small cell carcinoma of lung3CGI;CTD_human;ORPHANET
HgeneRB1C0678222Breast Carcinoma3CGI;CTD_human
HgeneRB1C0751483Familial Retinoblastoma3CTD_human;ORPHANET
HgeneRB1C1257931Mammary Neoplasms, Human3CTD_human
HgeneRB1C1458155Mammary Neoplasms3CTD_human
HgeneRB1C4704874Mammary Carcinoma, Human3CTD_human
HgeneRB1C0029463Osteosarcoma2CTD_human;ORPHANET
HgeneRB1C2239176Liver carcinoma2CTD_human
HgeneRB1C0001624Adrenal Gland Neoplasms1CTD_human
HgeneRB1C0007097Carcinoma1CTD_human
HgeneRB1C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneRB1C0007786Brain Ischemia1CTD_human
HgeneRB1C0014518Toxic Epidermal Necrolysis1CTD_human
HgeneRB1C0019207Hepatoma, Morris1CTD_human
HgeneRB1C0019208Hepatoma, Novikoff1CTD_human
HgeneRB1C0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
HgeneRB1C0023453L2 Acute Lymphoblastic Leukemia1CTD_human
HgeneRB1C0023904Liver Neoplasms, Experimental1CTD_human
HgeneRB1C0024667Animal Mammary Neoplasms1CTD_human
HgeneRB1C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneRB1C0027627Neoplasm Metastasis1CTD_human
HgeneRB1C0027659Neoplasms, Experimental1CTD_human
HgeneRB1C0030297Pancreatic Neoplasm1CTD_human
HgeneRB1C0033578Prostatic Neoplasms1CTD_human
HgeneRB1C0036920Sezary Syndrome1CTD_human
HgeneRB1C0038325Stevens-Johnson Syndrome1CTD_human
HgeneRB1C0086404Experimental Hepatoma1CTD_human
HgeneRB1C0205696Anaplastic carcinoma1CTD_human
HgeneRB1C0205697Carcinoma, Spindle-Cell1CTD_human
HgeneRB1C0205698Undifferentiated carcinoma1CTD_human
HgeneRB1C0205699Carcinomatosis1CTD_human
HgeneRB1C0206686Adrenocortical carcinoma1CTD_human
HgeneRB1C0238198Gastrointestinal Stromal Tumors1CTD_human
HgeneRB1C0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneRB1C0346647Malignant neoplasm of pancreas1CTD_human
HgeneRB1C0376358Malignant neoplasm of prostate1CTD_human
HgeneRB1C0750887Adrenal Cancer1CTD_human
HgeneRB1C0917798Cerebral Ischemia1CTD_human
HgeneRB1C1257925Mammary Carcinoma, Animal1CTD_human
HgeneRB1C1274933Drug-Induced Stevens Johnson Syndrome1CTD_human
HgeneRB1C1368275Pigmented Basal Cell Carcinoma1CTD_human
HgeneRB1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
HgeneRB1C2608045Trilateral Retinoblastoma1GENOMICS_ENGLAND
HgeneRB1C2930974Acute erythroleukemia1CTD_human
HgeneRB1C2930975Acute erythroleukemia - M6a subtype1CTD_human
HgeneRB1C2930976Acute myeloid leukemia FAB-M61CTD_human
HgeneRB1C2930977Acute erythroleukemia - M6b subtype1CTD_human
HgeneRB1C3151302Chromosome 13q14 deletion syndrome1ORPHANET
HgeneRB1C3179349Gastrointestinal Stromal Sarcoma1CTD_human
HgeneRB1C3658301Mycoplasma-Induced Stevens-Johnson Syndrome1CTD_human
HgeneRB1C3658302Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum1CTD_human
HgeneRB1C4721806Carcinoma, Basal Cell1CTD_human
TgeneC0001973Alcoholic Intoxication, Chronic5PSYGENET
TgeneC0005586Bipolar Disorder5PSYGENET
TgeneC0011570Mental Depression5PSYGENET
TgeneC0011581Depressive disorder5PSYGENET
TgeneC0041696Unipolar Depression5PSYGENET
TgeneC0525045Mood Disorders5PSYGENET
TgeneC1269683Major Depressive Disorder5PSYGENET
TgeneC0036341Schizophrenia4PSYGENET
TgeneC0524620Metabolic Syndrome X3CTD_human
TgeneC0028754Obesity2CTD_human
TgeneC0043094Weight Gain2CTD_human
TgeneC0085159Seasonal Affective Disorder2PSYGENET
TgeneC0009171Cocaine Abuse1PSYGENET
TgeneC0027796Neuralgia1CTD_human
TgeneC0038587Substance Withdrawal Syndrome1CTD_human
TgeneC0038870Neuralgia, Supraorbital1CTD_human
TgeneC0042656Neuralgia, Vidian1CTD_human
TgeneC0086189Drug Withdrawal Symptoms1CTD_human
TgeneC0087169Withdrawal Symptoms1CTD_human
TgeneC0234247Neuralgia, Atypical1CTD_human
TgeneC0234249Neuralgia, Stump1CTD_human
TgeneC0423711Neuralgia, Perineal1CTD_human
TgeneC0423712Neuralgia, Iliohypogastric Nerve1CTD_human
TgeneC0751217Hyperkinesia, Generalized1CTD_human
TgeneC0751371Neuralgia, Ilioinguinal1CTD_human
TgeneC0751372Nerve Pain1CTD_human
TgeneC0751373Paroxysmal Nerve Pain1CTD_human
TgeneC3887506Hyperkinesia1CTD_human