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Fusion gene:DHX35_DNTTIP1 (FusionGDB2 ID:HG60625TG116092) |
Fusion Gene Summary for DHX35_DNTTIP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DHX35_DNTTIP1 | Fusion gene ID: hg60625tg116092 | Hgene | Tgene | Gene symbol | DHX35 | DNTTIP1 | Gene ID | 60625 | 116092 |
| Gene name | DEAH-box helicase 35 | deoxynucleotidyltransferase terminal interacting protein 1 | |
| Synonyms | C20orf15|DDX35|KAIA0875 | C20orf167|Tdif1|dJ447F3.4 | |
| Cytomap | 20q11.23-q12 | 20q13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable ATP-dependent RNA helicase DHX35DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 35DEAH (Asp-Glu-Ala-His) box polypeptide 35DEAH-box protein 35 | deoxynucleotidyltransferase terminal-interacting protein 1TdT binding proteintdT-interacting factor 1terminal deoxynucleotidyltransferase-interacting factor 1 | |
| Modification date | 20240407 | 20240403 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000252011, ENST00000373323, ENST00000373325, | ||
| Fusion gene scores | * DoF score | * DoF score (Degree of Frequency) = # partners X # break points X # disease types 14 X 13 X 10=1820 | * DoF score (Degree of Frequency) = # partners X # break points X # disease types 2 X 9 X 4=72 |
| # samples | 21 | 7 | |
| ** MAII score | ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) log2(21/1820*10)=-3.11547721741994 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DHX35 [Title/Abstract] AND DNTTIP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | DHX35(37612419)-DNTTIP1(44439523), # samples:1 | ||
| Fusion gene breakpoints across DHX35 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across DNTTIP1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Breakpoints for DHX35_DNTTIP1 |
| RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section. |
| Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| DHX35 | chr20 | 37612419 | DNTTIP1 | chr20 | 37612419 |
| DHX35 | chr20 | 37612419 | DNTTIP1 | chr20 | 44439524 |
| DHX35 | chr20 | 38983776 | DNTTIP1 | chr20 | 45810885 |
| DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section. |
| Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | SV type |
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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for DHX35_DNTTIP1 |
| To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence. |
| Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions | Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity | Epigenetic Reprogramming / Histone Modifier Dysregulation | Chromatin Remodeling Dysregulation | Condensate-Driven Transcriptional Rewiring / LLP | Promoter / Enhancer Hijacking | Dominant-Negative Antagonism | Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation | Subcellular Mislocalization / Spatial Dysregulation | Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade |  |  |  |  |  |  |  |  |  |  |
* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.
| Fusion Gene Name | Mechanism Category | Mechanism PubMed | Tumorigenic Scenarios | Tumorigenic Scenario PubMed | Targeting Points | Targeting PubMed | Mechanism Background | Mechanism Background PubMed |
| DHX35-DNTTIP1 | Epigenetic Reprogramming / Histone Modifier Dysregulation M3 | Juxtaposition alters DNTTIP1 (TdIF1), dysregulating HDAC1/2 corepressor complex recruitment and core promoter transcription. | HDAC inhibitors (entinostat, vorinostat); epigenetic modulators | Solid tumors and leukemias |
* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.
| Fusion Gene Name | Mechanism Category | Mechanism PubMed | Tumorigenic Scenarios | Tumorigenic Scenario PubMed | Targeting Points | Targeting PubMed | Mechanism Background | Mechanism Background PubMed |
| DHX35-DNTTIP1 | Epigenetic Reprogramming / Histone Modifier Dysregulation M3 | Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 32591534; Title: The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure.; PMID: 35689852; Title: DNTTIP1 promotes nasopharyngeal carcinoma metastasis via recruiting HDAC1 to DUSP2 promoter and activating ERK signaling pathway. | Juxtaposition alters DNTTIP1 (TdIF1), dysregulating HDAC1/2 corepressor complex recruitment and core promoter transcription. | Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 35689852; Title: DNTTIP1 promotes nasopharyngeal carcinoma metastasis via recruiting HDAC1 to DUSP2 promoter and activating ERK signaling pathway. | HDAC inhibitors (entinostat, vorinostat); epigenetic modulators | Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 35689852; Title: DNTTIP1 promotes nasopharyngeal carcinoma metastasis via recruiting HDAC1 to DUSP2 promoter and activating ERK signaling pathway.; PMID: 29855544; Title: Critical role of deoxynucleotidyl transferase terminal interacting protein 1 in oral cancer. | Solid tumors and leukemias | Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 35689852; Title: DNTTIP1 promotes nasopharyngeal carcinoma metastasis via recruiting HDAC1 to DUSP2 promoter and activating ERK signaling pathway.; PMID: 29855544; Title: Critical role of deoxynucleotidyl transferase terminal interacting protein 1 in oral cancer. |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
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Fusion Genomic Features for DHX35_DNTTIP1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| DHX35 | chr20 | 37612419 | + | DNTTIP1 | chr20 | 44439523 | + | 3.52e-05 | 1.00e+00 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases). |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases). |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF). |
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Fusion Gene ORF Annotations for DHX35_DNTTIP1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000252011 | ENST00000372622 | DHX35 | chr20 | 37612419 | + | DNTTIP1 | chr20 | 44439523 | + |
| In-frame | ENST00000373323 | ENST00000372622 | DHX35 | chr20 | 37612419 | + | DNTTIP1 | chr20 | 44439523 | + |
| In-frame | ENST00000373325 | ENST00000372622 | DHX35 | chr20 | 37612419 | + | DNTTIP1 | chr20 | 44439523 | + |
| ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| ENST00000252011 | ENST00000372622 | DHX35 | chr20 | 37612419 | DNTTIP1 | chr20 | 44439523 | 378 | 179 |
| ENST00000373323 | ENST00000372622 | DHX35 | chr20 | 37612419 | DNTTIP1 | chr20 | 44439523 | 276 | 179 |
| ENST00000373325 | ENST00000372622 | DHX35 | chr20 | 37612419 | DNTTIP1 | chr20 | 44439523 | 414 | 570 |
| ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| ENST00000252011 | ENST00000372622 | DHX35 | chr20 | 37612419 | DNTTIP1 | chr20 | 44439523 | 6.11e-03 | 9.94e-01 |
| ENST00000373323 | ENST00000372622 | DHX35 | chr20 | 37612419 | DNTTIP1 | chr20 | 44439523 | 1.03e-02 | 9.90e-01 |
| ENST00000373325 | ENST00000372622 | DHX35 | chr20 | 37612419 | DNTTIP1 | chr20 | 44439523 | 5.83e-03 | 9.94e-01 |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins). |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins). |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
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Fusion Protein Retained/Non-Retained Functional Features for DHX35_DNTTIP1 |
| Protein Level Annotation from FGviewer * Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS. |
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| - In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length). |
DHX35_DNTTIP1_chr20-37612419_chr20-44439523.png |
| - In-frame and retained protein feature among the 13 regional features (texts). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DHX35 | chr20:37612419 | chr20:44439523 | ENST00000252011 | Q9H5Z1 | 4 | 22 | 261_438 | 115.0 | 704.0 | Domain | Helicase C-terminal |
| Hgene | DHX35 | chr20:37612419 | chr20:44439523 | ENST00000252011 | Q9H5Z1 | 4 | 22 | 64_229 | 115.0 | 704.0 | Domain | Helicase ATP-binding |
| Hgene | DHX35 | chr20:37612419 | chr20:44439523 | ENST00000252011 | Q9H5Z1 | 4 | 22 | 176_179 | 115.0 | 704.0 | Motif | Note=DEAH box |
| Tgene | DNTTIP1 | chr20:37612419 | chr20:44439523 | ENST00000372622 | Q9H147 | 10 | 13 | 147_158 | 265.0 | 330.0 | Compositional bias | Basic and acidic residues |
| Tgene | DNTTIP1 | chr20:37612419 | chr20:44439523 | ENST00000372622 | Q9H147 | 10 | 13 | 159_173 | 265.0 | 330.0 | DNA binding | A.T hook |
| Tgene | DNTTIP1 | chr20:37612419 | chr20:44439523 | ENST00000372622 | Q9H147 | 10 | 13 | 216_237 | 265.0 | 330.0 | DNA binding | H-T-H motif |
| Tgene | DNTTIP1 | chr20:37612419 | chr20:44439523 | ENST00000372622 | Q9H147 | 10 | 13 | 164_170 | 265.0 | 330.0 | Motif | Nuclear localization signal |
| Tgene | DNTTIP1 | chr20:37612419 | chr20:44439523 | ENST00000372622 | Q9H147 | 10 | 13 | 147_178 | 265.0 | 330.0 | Region | Disordered |
| Tgene | DNTTIP1 | chr20:37612419 | chr20:44439523 | ENST00000372622 | Q9H147 | 10 | 13 | 197_316 | 265.0 | 330.0 | Region | Important for DNA and nucleosome binding |
| Tgene | DNTTIP1 | chr20:37612419 | chr20:44439523 | ENST00000372622 | Q9H147 | 10 | 13 | 1_22 | 265.0 | 330.0 | Region | Disordered |
| Tgene | DNTTIP1 | chr20:37612419 | chr20:44439523 | ENST00000372622 | Q9H147 | 10 | 13 | 56_147 | 265.0 | 330.0 | Region | Important for dimerization |
| - Retained PPIs in in-frame fusion. |
| Partner | Hgene | Hbp | Tgene | Tbp | ENST | UniProt | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Hgene | Hbp | Tgene | Tbp | ENST | UniProt | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Fusion Transcript Sequence for DHX35_DNTTIP1 |
| In-frame Fusion Transcript Sequences. |
>DHX35_DNTTIP1_ENST00000252011_ENST00000372622_37612419_44439523 length=805nt Breakpoint=378nt GGTGGAGCTAGCCTCGTGACCTTTTACCCCAACATGGCTGCGCCCGTGGGACCGGTGAAGTTCTGGCGACCCGGTACAGAGGGGCCAGGTGTAAGCATCTCTGAAGAGAGACAAAGTCTGGCTGAAAACTCTGGGACAACGGTTGTTTAC AACCCTTATGCTGCCCTTTCCATAGAGCAGCAGAGGCAGAAGCTGCCGGTATTCAAGCTTAGGAATCATATTTTATACTTGATAGAAAATTATCAGACAGTGGTGATTGTTGGTGAAACAGGATGTGGGAAGAGCACACAGATTCCTCAG TACCTTGCAGAAGCCGGCTGGACAGCTGAAGGAAGAGTGGTAGGAGTGACCCAGCCTCGAAGAGTGGCTGCTGTTACAGCCTACCTCCTCATCGAGGAGGACATCCGGGACCTTGCGGCCAGTGATGATTACAGAGGATGCCTGGATCTG AAGCTAGAGGAATTGAAATCCTTTGTCCTACCCTCCTGGATGGTGGAGAAGATGAGAAAGTATATGGAGACACTACGGACAGAGAATGAGCATCGTGCTGTTGAAGCACCTCCACAGACCTGAGGCCGGGTCCCCTGGCCACACTTGGCA GCCCTCCTCCAAAGCCCTCTTCCTCACGTGGCTGAGGCCACCGCTGGGACTGCTCCTAGATGGATCTCAGCGGCATTAAGCTGTGCCTGAGCGAGTTTGTAGTGACTCACTGCACAGCACCCCCAGACTAGCATGTGGTTCTATATTTGT AAAGTTATTGGGATAAGAAACAATTAAACAGTTTGTAGTAAACACAGATGGTGAA >DHX35_DNTTIP1_ENST00000373323_ENST00000372622_37612419_44439523 length=703nt Breakpoint=276nt AGCCTCGTGACCTTTTACCCCAACATGGCTGCGCCCGTGGGACCGGTGAAGTTCTGGCGACCCGGTACAGAGGGGCCAGGTGTAAGCATCTCTGAAGAGAGACAAAGTCTGGCTGAAAACTCTGGGACAACGGTTGTTTACAACCCTTAT GCTGCCCTTTCCATAGAGCAGCAGAGGCAGAAGCTGCCGGTATTCAAGTACCTTGCAGAAGCCGGCTGGACAGCTGAAGGAAGAGTGGTAGGAGTGACCCAGCCTCGAAGAGTGGCTGCTGTTACAGCCTACCTCCTCATCGAGGAGGAC ATCCGGGACCTTGCGGCCAGTGATGATTACAGAGGATGCCTGGATCTGAAGCTAGAGGAATTGAAATCCTTTGTCCTACCCTCCTGGATGGTGGAGAAGATGAGAAAGTATATGGAGACACTACGGACAGAGAATGAGCATCGTGCTGTT GAAGCACCTCCACAGACCTGAGGCCGGGTCCCCTGGCCACACTTGGCAGCCCTCCTCCAAAGCCCTCTTCCTCACGTGGCTGAGGCCACCGCTGGGACTGCTCCTAGATGGATCTCAGCGGCATTAAGCTGTGCCTGAGCGAGTTTGTAG TGACTCACTGCACAGCACCCCCAGACTAGCATGTGGTTCTATATTTGTAAAGTTATTGGGATAAGAAACAATTAAACAGTTTGTAGTAAACACAGATGGTGAA >DHX35_DNTTIP1_ENST00000373325_ENST00000372622_37612419_44439523 length=841nt Breakpoint=414nt CCCTCCGGGCCCTGGGGGCCTAGCGCGCGACGGTGGGGTGGAGCTAGCCTCGTGACCTTTTACCCCAACATGGCTGCGCCCGTGGGACCGGTGAAGTTCTGGCGACCCGGTACAGAGGGGCCAGGTGTAAGCATCTCTGAAGAGAGACAA AGTCTGGCTGAAAACTCTGGGACAACGGTTGTTTACAACCCTTATGCTGCCCTTTCCATAGAGCAGCAGAGGCAGAAGCTGCCGGTATTCAAGCTTAGGAATCATATTTTATACTTGATAGAAAATTATCAGACAGTGGTGATTGTTGGT GAAACAGGATGTGGGAAGAGCACACAGATTCCTCAGTACCTTGCAGAAGCCGGCTGGACAGCTGAAGGAAGAGTGGTAGGAGTGACCCAGCCTCGAAGAGTGGCTGCTGTTACAGCCTACCTCCTCATCGAGGAGGACATCCGGGACCTT GCGGCCAGTGATGATTACAGAGGATGCCTGGATCTGAAGCTAGAGGAATTGAAATCCTTTGTCCTACCCTCCTGGATGGTGGAGAAGATGAGAAAGTATATGGAGACACTACGGACAGAGAATGAGCATCGTGCTGTTGAAGCACCTCCA CAGACCTGAGGCCGGGTCCCCTGGCCACACTTGGCAGCCCTCCTCCAAAGCCCTCTTCCTCACGTGGCTGAGGCCACCGCTGGGACTGCTCCTAGATGGATCTCAGCGGCATTAAGCTGTGCCTGAGCGAGTTTGTAGTGACTCACTGCA CAGCACCCCCAGACTAGCATGTGGTTCTATATTTGTAAAGTTATTGGGATAAGAAACAATTAAACAGTTTGTAGTAAACACAGATGGTGAA |
| N-Truncated Transcript (5UTR-3CDS) Sequences |
| C-Truncated Transcript (5CDS-3UTR) Sequences |
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Fusion Protein Sequence for DHX35_DNTTIP1 |
| In-frame Fusion Protein Sequences. |
>DHX35_DNTTIP1_ENST00000252011_ENST00000372622_37612419_44439523 length=179nt MAAPVGPVKFWRPGTEGPGVSISEERQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLP SWMVEKMRKYMETLRTENEHRAVEAPPQT >DHX35_DNTTIP1_ENST00000373323_ENST00000372622_37612419_44439523 length=179nt MAAPVGPVKFWRPGTEGPGVSISEERQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLP SWMVEKMRKYMETLRTENEHRAVEAPPQT >DHX35_DNTTIP1_ENST00000373325_ENST00000372622_37612419_44439523 length=570nt MRLLLWISNMPPPRTREGRDRRDHHRAPSEEEALEKWDWNCPETRRLLEDAFFREEDYIRQGSEECQKFWTFFERLQRFQNLKTSRKEEKDPGQPKHSIPALADLPRTYDPRYRINLSVLGPATRGSQGLGRHLPAERVAEFRRALLHYL DFGQKQAFGRLAKLQRERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLLAAGFSHVACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQIQREPSLPQYEVLIVDEVHERHLHNDFL LGVLQRLLPTRPDLKVILMSATINISLFSSYFSNAPVVQVPGRLFPITVVYQPQEAEPTTSKSEKLDPRPFLRVLESIDHKYPPEERGDLLVFLSGMAEISAVLEAAQTYASHTQRWVVLPLHSALSVADQDKVFDVAPPGVRKCILSTN IAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTGPGVCFRLYAESDYDAFAPYPVPEIRRVALDSLVLQALSQRDPPHNNFFFFDGMKGNGIVECLGPK |
| N-Truncated Protein (5UTR-3CDS) Sequences |
| C-Truncated Protein (5CDS-3UTR) Sequences |
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Personalized Fusion Protein Sequence for DHX35_DNTTIP1 |
| TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences |
| Num | Gene Group | Domain Loci | Fusion Protein ID | Fusion Gene Name | Partner | Mutated Residue in WT Protein | Seq. Length | Mutated Residue in Fusion Protein |
| CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences |
| Num | Gene Group | Domain Loci | Fusion Protein ID | Fusion Gene Name | Partner | Mutated Residue in WT Protein | Seq. Length | Mutated Residue in Fusion Protein |
| TCGA All Mutated Fusion Protein Sequences |
>DHX35_DNTTIP1_ENST00000252011_ENST00000372622_37612419_44439523_5-gene_p.G17E_179_G17E length=179AA MAAPVGPVKFWRPGTEEPGVSISEERQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLP SWMVEKMRKYMETLRTENEHRAVEAPPQT >DHX35_DNTTIP1_ENST00000252011_ENST00000372622_37612419_44439523_5-gene_p.V8A_179_V8A length=179AA MAAPVGPAKFWRPGTEGPGVSISEERQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLP SWMVEKMRKYMETLRTENEHRAVEAPPQT >DHX35_DNTTIP1_ENST00000252011_ENST00000372622_37612419_44439523_5-gene_p.C81Y_179_C81Y length=179AA MAAPVGPVKFWRPGTEGPGVSISEERQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGYGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLP SWMVEKMRKYMETLRTENEHRAVEAPPQT >DHX35_DNTTIP1_ENST00000252011_ENST00000372622_37612419_44439523_5-gene_p.L29V_179_L29V length=179AA MAAPVGPVKFWRPGTEGPGVSISEERQSVAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLP SWMVEKMRKYMETLRTENEHRAVEAPPQT >DHX35_DNTTIP1_ENST00000252011_ENST00000372622_37612419_44439523_5-gene_p.E25K_179_E25K length=179AA MAAPVGPVKFWRPGTEGPGVSISEKRQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLP SWMVEKMRKYMETLRTENEHRAVEAPPQT >DHX35_DNTTIP1_ENST00000252011_ENST00000372622_37612419_44439523_5-gene_p.E16D_179_E16D length=179AA MAAPVGPVKFWRPGTDGPGVSISEERQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLP SWMVEKMRKYMETLRTENEHRAVEAPPQT >DHX35_DNTTIP1_ENST00000252011_ENST00000372622_37612419_44439523_5-gene_p.V76A_179_V76A length=179AA MAAPVGPVKFWRPGTEGPGVSISEERQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIAGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLP SWMVEKMRKYMETLRTENEHRAVEAPPQT >DHX35_DNTTIP1_ENST00000252011_ENST00000372622_37612419_44439523_5-gene_p.S28R_179_S28R length=179AA MAAPVGPVKFWRPGTEGPGVSISEERQRLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLP SWMVEKMRKYMETLRTENEHRAVEAPPQT >DHX35_DNTTIP1_ENST00000252011_ENST00000372622_37612419_44439523_5-gene_p.E93K_179_E93K length=179AA MAAPVGPVKFWRPGTEGPGVSISEERQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAKAGWTAEGRVVGVTQPRRVAAVTAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLP SWMVEKMRKYMETLRTENEHRAVEAPPQT >DHX35_DNTTIP1_ENST00000252011_ENST00000372622_37612419_44439523_5-gene_p.I87V_179_I87V length=179AA MAAPVGPVKFWRPGTEGPGVSISEERQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQVPQYLAEAGWTAEGRVVGVTQPRRVAAVTAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLP SWMVEKMRKYMETLRTENEHRAVEAPPQT >DHX35_DNTTIP1_ENST00000373323_ENST00000372622_37612419_44439523_5-gene_p.G17E_179_G17E length=179AA MAAPVGPVKFWRPGTEEPGVSISEERQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLP SWMVEKMRKYMETLRTENEHRAVEAPPQT >DHX35_DNTTIP1_ENST00000373323_ENST00000372622_37612419_44439523_5-gene_p.V8A_179_V8A length=179AA MAAPVGPAKFWRPGTEGPGVSISEERQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLP SWMVEKMRKYMETLRTENEHRAVEAPPQT >DHX35_DNTTIP1_ENST00000373323_ENST00000372622_37612419_44439523_5-gene_p.C81Y_179_C81Y length=179AA MAAPVGPVKFWRPGTEGPGVSISEERQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGYGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLP SWMVEKMRKYMETLRTENEHRAVEAPPQT >DHX35_DNTTIP1_ENST00000373323_ENST00000372622_37612419_44439523_5-gene_p.L29V_179_L29V length=179AA MAAPVGPVKFWRPGTEGPGVSISEERQSVAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLP SWMVEKMRKYMETLRTENEHRAVEAPPQT >DHX35_DNTTIP1_ENST00000373323_ENST00000372622_37612419_44439523_5-gene_p.E25K_179_E25K length=179AA MAAPVGPVKFWRPGTEGPGVSISEKRQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLP SWMVEKMRKYMETLRTENEHRAVEAPPQT >DHX35_DNTTIP1_ENST00000373323_ENST00000372622_37612419_44439523_5-gene_p.E16D_179_E16D length=179AA MAAPVGPVKFWRPGTDGPGVSISEERQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLP SWMVEKMRKYMETLRTENEHRAVEAPPQT >DHX35_DNTTIP1_ENST00000373323_ENST00000372622_37612419_44439523_5-gene_p.V76A_179_V76A length=179AA MAAPVGPVKFWRPGTEGPGVSISEERQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIAGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLP SWMVEKMRKYMETLRTENEHRAVEAPPQT >DHX35_DNTTIP1_ENST00000373323_ENST00000372622_37612419_44439523_5-gene_p.S28R_179_S28R length=179AA MAAPVGPVKFWRPGTEGPGVSISEERQRLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLP SWMVEKMRKYMETLRTENEHRAVEAPPQT >DHX35_DNTTIP1_ENST00000373323_ENST00000372622_37612419_44439523_5-gene_p.E93K_179_E93K length=179AA MAAPVGPVKFWRPGTEGPGVSISEERQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAKAGWTAEGRVVGVTQPRRVAAVTAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLP SWMVEKMRKYMETLRTENEHRAVEAPPQT >DHX35_DNTTIP1_ENST00000373323_ENST00000372622_37612419_44439523_5-gene_p.I87V_179_I87V length=179AA MAAPVGPVKFWRPGTEGPGVSISEERQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQVPQYLAEAGWTAEGRVVGVTQPRRVAAVTAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLP SWMVEKMRKYMETLRTENEHRAVEAPPQT |
| Fusion Protein ID | Sample ID | Mutated Partner | AAchange in WT | Seq. Length | AAchange in Fusion |
| ENST00000252011_ENST00000372622_37612419_44439523 | TCGA-55-7911-01A | 5-gene | p.G17E | 179 | G17E |
| ENST00000252011_ENST00000372622_37612419_44439523 | TCGA-A5-A1OF-01A | 5-gene | p.V8A | 179 | V8A |
| ENST00000252011_ENST00000372622_37612419_44439523 | TCGA-BR-8487-01A | 5-gene | p.C81Y | 179 | C81Y |
| ENST00000252011_ENST00000372622_37612419_44439523 | TCGA-CL-5917-01A | 5-gene | p.L29V | 179 | L29V |
| ENST00000252011_ENST00000372622_37612419_44439523 | TCGA-DA-A95X-06A | 5-gene | p.E25K | 179 | E25K |
| ENST00000252011_ENST00000372622_37612419_44439523 | TCGA-DZ-6135-01A | 5-gene | p.E16D | 179 | E16D |
| ENST00000252011_ENST00000372622_37612419_44439523 | TCGA-EE-A20C-06A | 5-gene | p.V76A | 179 | V76A |
| ENST00000252011_ENST00000372622_37612419_44439523 | TCGA-EO-A22U-01A | 5-gene | p.S28R | 179 | S28R |
| ENST00000252011_ENST00000372622_37612419_44439523 | TCGA-F7-A623-01A | 5-gene | p.E93K | 179 | E93K |
| ENST00000252011_ENST00000372622_37612419_44439523 | TCGA-S9-A89V-01A | 5-gene | p.I87V | 179 | I87V |
| ENST00000373323_ENST00000372622_37612419_44439523 | TCGA-55-7911-01A | 5-gene | p.G17E | 179 | G17E |
| ENST00000373323_ENST00000372622_37612419_44439523 | TCGA-A5-A1OF-01A | 5-gene | p.V8A | 179 | V8A |
| ENST00000373323_ENST00000372622_37612419_44439523 | TCGA-BR-8487-01A | 5-gene | p.C81Y | 179 | C81Y |
| ENST00000373323_ENST00000372622_37612419_44439523 | TCGA-CL-5917-01A | 5-gene | p.L29V | 179 | L29V |
| ENST00000373323_ENST00000372622_37612419_44439523 | TCGA-DA-A95X-06A | 5-gene | p.E25K | 179 | E25K |
| ENST00000373323_ENST00000372622_37612419_44439523 | TCGA-DZ-6135-01A | 5-gene | p.E16D | 179 | E16D |
| ENST00000373323_ENST00000372622_37612419_44439523 | TCGA-EE-A20C-06A | 5-gene | p.V76A | 179 | V76A |
| ENST00000373323_ENST00000372622_37612419_44439523 | TCGA-EO-A22U-01A | 5-gene | p.S28R | 179 | S28R |
| ENST00000373323_ENST00000372622_37612419_44439523 | TCGA-F7-A623-01A | 5-gene | p.E93K | 179 | E93K |
| ENST00000373323_ENST00000372622_37612419_44439523 | TCGA-S9-A89V-01A | 5-gene | p.I87V | 179 | I87V |
| CCLE All Mutated Fusion Protein Sequences |
| Fusion Protein ID | Sample ID | Mutated Partner | AAchange in WT | Seq. Length | AAchange in Fusion |
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Fusion Gene Exprssed Samples for DHX35_DNTTIP1 |
| RNA-seq based fusion gene expressed samples. |
| Source | Study | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB | BRCA | TCGA-AR-A0TW-01A | DHX35 | chr20 | 37612419 | - | DNTTIP1 | chr20 | 0 | + | |
| ChimerDB | BRCA | TCGA-AR-A0TW-01A | DHX35 | chr20 | 37612419 | + | DNTTIP1 | chr20 | 37612419 | + | |
| ChimerDB | BRCA | TCGA-AR-A0TW-01A | DHX35 | chr20 | 37612419 | + | DNTTIP1 | chr20 | 44439524 | + | |
| TCGAfusionPortal | BRCA | TCGA-AR-A0TW-01A | DHX35 | chr20 | 37612419 | + | DNTTIP1 | chr20 | 44439524 | + | |
| WashU | BRCA | TCGA-AR-A0TW-01A | DHX35 | chr20 | 37612419 | + | DNTTIP1 | chr20 | 44439524 | + | |
| cBioPortal | BRCA_TCGA_PAN_CAN_ATLAS_2018 | BRCA | TCGA-AR-A0TW-01 | DHX35 | chr20 | 38983776 | DNTTIP1 | chr20 | 45810885 |
| DNA-seq based fusion gene expressed samples. |
| Source | Study | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | SV type |
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Related Drugs for DHX35_DNTTIP1 |
| PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug'] * For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub. |
| PMID | Fusion Gene Name | Drug | Study Title |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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