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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZFAND3-GABRA3 (FusionGDB2 ID:HG60685TG2556)

Fusion Gene Summary for ZFAND3-GABRA3

check button Fusion gene summary
Fusion gene informationFusion gene name: ZFAND3-GABRA3
Fusion gene ID: hg60685tg2556
HgeneTgene
Gene symbol

ZFAND3

GABRA3

Gene ID

60685

2556

Gene namezinc finger AN1-type containing 3gamma-aminobutyric acid type A receptor subunit alpha3
SynonymsTEX27-
Cytomap('ZFAND3')('GABRA3')

6p21.2

Xq28

Type of geneprotein-codingprotein-coding
DescriptionAN1-type zinc finger protein 3testis expressed sequence 27testis-expressed protein 27zinc finger, AN1-type domain 3gamma-aminobutyric acid receptor subunit alpha-3GABA(A) receptor subunit alpha-3GABA(A) receptor, alpha 3gamma-aminobutyric acid (GABA) A receptor, alpha 3gamma-aminobutyric acid type A receptor alpha3 subunitgamma-animobutyric acid (GABA) A receptor
Modification date2020031320200313
UniProtAcc.

P34903

Ensembl transtripts involved in fusion geneENST00000287218, ENST00000373391, 
ENST00000463847, 
Fusion gene scores* DoF score39 X 11 X 14=60068 X 6 X 6=288
# samples 437
** MAII scorelog2(43/6006*10)=-3.80399590996769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/288*10)=-2.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZFAND3 [Title/Abstract] AND GABRA3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZFAND3(37897775)-GABRA3(151533068), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-6822-01AZFAND3chr6

37897775

+GABRA3chrX

151533068

-


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Fusion Gene ORF analysis for ZFAND3-GABRA3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000287218ENST00000370314ZFAND3chr6

37897775

+GABRA3chrX

151533068

-
5CDS-5UTRENST00000287218ENST00000535043ZFAND3chr6

37897775

+GABRA3chrX

151533068

-
5CDS-5UTRENST00000373391ENST00000370314ZFAND3chr6

37897775

+GABRA3chrX

151533068

-
5CDS-5UTRENST00000373391ENST00000535043ZFAND3chr6

37897775

+GABRA3chrX

151533068

-
5CDS-intronENST00000287218ENST00000497894ZFAND3chr6

37897775

+GABRA3chrX

151533068

-
5CDS-intronENST00000373391ENST00000497894ZFAND3chr6

37897775

+GABRA3chrX

151533068

-
intron-5UTRENST00000463847ENST00000370314ZFAND3chr6

37897775

+GABRA3chrX

151533068

-
intron-5UTRENST00000463847ENST00000535043ZFAND3chr6

37897775

+GABRA3chrX

151533068

-
intron-intronENST00000463847ENST00000497894ZFAND3chr6

37897775

+GABRA3chrX

151533068

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ZFAND3-GABRA3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for ZFAND3-GABRA3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:37897775/:151533068)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GABRA3

P34903

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ZFAND3-GABRA3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ZFAND3-GABRA3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZFAND3-GABRA3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGABRA3P34903DB00395CarisoprodolModulatorSmall moleculeApproved
TgeneGABRA3P34903DB00425ZolpidemAgonistSmall moleculeApproved
TgeneGABRA3P34903DB00849MethylphenobarbitalPotentiatorSmall moleculeApproved
TgeneGABRA3P34903DB00898EthanolSmall moleculeApproved
TgeneGABRA3P34903DB01198ZopiclonePotentiatorSmall moleculeApproved
TgeneGABRA3P34903DB00241ButalbitalPotentiatorSmall moleculeApproved|Illicit
TgeneGABRA3P34903DB00306TalbutalPotentiatorSmall moleculeApproved|Illicit
TgeneGABRA3P34903DB00371MeprobamateAgonistSmall moleculeApproved|Illicit
TgeneGABRA3P34903DB01351AmobarbitalPotentiatorSmall moleculeApproved|Illicit
TgeneGABRA3P34903DB01353ButobarbitalPotentiatorSmall moleculeApproved|Illicit
TgeneGABRA3P34903DB00402EszopicloneAgonistSmall moleculeApproved|Investigational
TgeneGABRA3P34903DB00312PentobarbitalPotentiatorSmall moleculeApproved|Investigational|Vet_approved
TgeneGABRA3P34903DB00418SecobarbitalPotentiatorSmall moleculeApproved|Vet_approved
TgeneGABRA3P34903DB00599ThiopentalPotentiatorSmall moleculeApproved|Vet_approved
TgeneGABRA3P34903DB00794PrimidonePotentiatorSmall moleculeApproved|Vet_approved

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Related Diseases for ZFAND3-GABRA3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZFAND3C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneZFAND3C0087031Juvenile-Onset Still Disease1CTD_human
HgeneZFAND3C3495559Juvenile arthritis1CTD_human
HgeneZFAND3C3714758Juvenile psoriatic arthritis1CTD_human
HgeneZFAND3C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneZFAND3C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
TgeneC0005586Bipolar Disorder5PSYGENET
TgeneC0004352Autistic Disorder1CTD_human
TgeneC0011570Mental Depression1PSYGENET
TgeneC0011581Depressive disorder1PSYGENET
TgeneC0268446Thyrotoxic periodic paralysis1ORPHANET