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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CCL5-ZAP70 (FusionGDB2 ID:HG6352TG7535) |
Fusion Gene Summary for CCL5-ZAP70 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CCL5-ZAP70 | Fusion gene ID: hg6352tg7535 | Hgene | Tgene | Gene symbol | CCL5 | ZAP70 | Gene ID | 6352 | 7535 |
| Gene name | C-C motif chemokine ligand 5 | zeta chain of T cell receptor associated protein kinase 70 | |
| Synonyms | D17S136E|RANTES|SCYA5|SIS-delta|SISd|TCP228|eoCP | ADMIO2|IMD48|SRK|STCD|STD|TZK|ZAP-70 | |
| Cytomap | ('CCL5')('ZAP70') 17q12 | 2q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | C-C motif chemokine 5T-cell specific protein p288beta-chemokine RANTESchemokine (C-C motif) ligand 5eosinophil chemotactic cytokineregulated upon activation, normally T-expressed, and presumably secretedsmall inducible cytokine subfamily A (Cys-Cys) | tyrosine-protein kinase ZAP-7070 kDa zeta-associated protein70 kDa zeta-chain associated proteinsyk-related tyrosine kinasezeta chain of T cell receptor associated protein kinase 70kDazeta-chain (TCR) associated protein kinase 70kDazeta-chain associ | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000293272, ENST00000366113, | ||
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: CCL5 [Title/Abstract] AND ZAP70 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CCL5(34206530)-ZAP70(98351769), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CCL5 | GO:0006816 | calcium ion transport | 10734056 |
| Hgene | CCL5 | GO:0006874 | cellular calcium ion homeostasis | 10734056 |
| Hgene | CCL5 | GO:0006887 | exocytosis | 10734056 |
| Hgene | CCL5 | GO:0006954 | inflammatory response | 21147091 |
| Hgene | CCL5 | GO:0007159 | leukocyte cell-cell adhesion | 8558019 |
| Hgene | CCL5 | GO:0007186 | G protein-coupled receptor signaling pathway | 17001303|23979485 |
| Hgene | CCL5 | GO:0007267 | cell-cell signaling | 8558019 |
| Hgene | CCL5 | GO:0009636 | response to toxic substance | 10841574 |
| Hgene | CCL5 | GO:0010759 | positive regulation of macrophage chemotaxis | 16778803 |
| Hgene | CCL5 | GO:0010820 | positive regulation of T cell chemotaxis | 1699135|7544376|16778803|18337562 |
| Hgene | CCL5 | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling | 7544376 |
| Hgene | CCL5 | GO:0014911 | positive regulation of smooth muscle cell migration | 21297082 |
| Hgene | CCL5 | GO:0030335 | positive regulation of cell migration | 7545673 |
| Hgene | CCL5 | GO:0031328 | positive regulation of cellular biosynthetic process | 18337562 |
| Hgene | CCL5 | GO:0031584 | activation of phospholipase D activity | 9469451 |
| Hgene | CCL5 | GO:0031663 | lipopolysaccharide-mediated signaling pathway | 21147091 |
| Hgene | CCL5 | GO:0033634 | positive regulation of cell-cell adhesion mediated by integrin | 8558019 |
| Hgene | CCL5 | GO:0034112 | positive regulation of homotypic cell-cell adhesion | 10488085 |
| Hgene | CCL5 | GO:0042102 | positive regulation of T cell proliferation | 18832695 |
| Hgene | CCL5 | GO:0042119 | neutrophil activation | 10488085 |
| Hgene | CCL5 | GO:0042327 | positive regulation of phosphorylation | 18337562 |
| Hgene | CCL5 | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein | 9417081 |
| Hgene | CCL5 | GO:0043922 | negative regulation by host of viral transcription | 10841574 |
| Hgene | CCL5 | GO:0045071 | negative regulation of viral genome replication | 10490959 |
| Hgene | CCL5 | GO:0045744 | negative regulation of G protein-coupled receptor signaling pathway | 10734056 |
| Hgene | CCL5 | GO:0045785 | positive regulation of cell adhesion | 10910894 |
| Hgene | CCL5 | GO:0048245 | eosinophil chemotaxis | 16778803 |
| Hgene | CCL5 | GO:0048661 | positive regulation of smooth muscle cell proliferation | 21297082 |
| Hgene | CCL5 | GO:0050796 | regulation of insulin secretion | 23979485 |
| Hgene | CCL5 | GO:0050863 | regulation of T cell activation | 10488085 |
| Hgene | CCL5 | GO:0051928 | positive regulation of calcium ion transport | 8699119 |
| Hgene | CCL5 | GO:0070098 | chemokine-mediated signaling pathway | 17001303 |
| Hgene | CCL5 | GO:0070233 | negative regulation of T cell apoptotic process | 10488085 |
| Hgene | CCL5 | GO:0070234 | positive regulation of T cell apoptotic process | 10488085 |
| Hgene | CCL5 | GO:0071407 | cellular response to organic cyclic compound | 21147091 |
| Hgene | CCL5 | GO:0090026 | positive regulation of monocyte chemotaxis | 1699135|19779041 |
| Hgene | CCL5 | GO:1901214 | regulation of neuron death | 17001303 |
| Hgene | CCL5 | GO:2000406 | positive regulation of T cell migration | 23620790 |
| Hgene | CCL5 | GO:2000503 | positive regulation of natural killer cell chemotaxis | 7545673 |
| Tgene | ZAP70 | GO:0006468 | protein phosphorylation | 12447358 |
| Tgene | ZAP70 | GO:0006955 | immune response | 1423621 |
| Tgene | ZAP70 | GO:0018108 | peptidyl-tyrosine phosphorylation | 22732588 |
| Tgene | ZAP70 | GO:0045059 | positive thymic T cell selection | 7630421 |
| Tgene | ZAP70 | GO:0045582 | positive regulation of T cell differentiation | 7630421 |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | AG266142 | CCL5 | chr17 | 34206530 | - | ZAP70 | chr2 | 98351769 | + |
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Fusion Gene ORF analysis for CCL5-ZAP70 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000293272 | ENST00000264972 | CCL5 | chr17 | 34206530 | - | ZAP70 | chr2 | 98351769 | + |
| intron-3CDS | ENST00000366113 | ENST00000264972 | CCL5 | chr17 | 34206530 | - | ZAP70 | chr2 | 98351769 | + |
| intron-3UTR | ENST00000293272 | ENST00000442208 | CCL5 | chr17 | 34206530 | - | ZAP70 | chr2 | 98351769 | + |
| intron-3UTR | ENST00000293272 | ENST00000451498 | CCL5 | chr17 | 34206530 | - | ZAP70 | chr2 | 98351769 | + |
| intron-3UTR | ENST00000293272 | ENST00000463643 | CCL5 | chr17 | 34206530 | - | ZAP70 | chr2 | 98351769 | + |
| intron-3UTR | ENST00000366113 | ENST00000442208 | CCL5 | chr17 | 34206530 | - | ZAP70 | chr2 | 98351769 | + |
| intron-3UTR | ENST00000366113 | ENST00000451498 | CCL5 | chr17 | 34206530 | - | ZAP70 | chr2 | 98351769 | + |
| intron-3UTR | ENST00000366113 | ENST00000463643 | CCL5 | chr17 | 34206530 | - | ZAP70 | chr2 | 98351769 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CCL5-ZAP70 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for CCL5-ZAP70 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:34206530/:98351769) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CCL5-ZAP70 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for CCL5-ZAP70 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CCL5-ZAP70 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CCL5-ZAP70 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CCL5 | C0004096 | Asthma | 1 | CTD_human |
| Hgene | CCL5 | C0008312 | Primary biliary cirrhosis | 1 | CTD_human |
| Hgene | CCL5 | C0011615 | Dermatitis, Atopic | 1 | CTD_human |
| Hgene | CCL5 | C0017658 | Glomerulonephritis | 1 | CTD_human |
| Hgene | CCL5 | C0019187 | Hepatitis, Alcoholic | 1 | CTD_human |
| Hgene | CCL5 | C0020500 | Hyperoxaluria | 1 | CTD_human |
| Hgene | CCL5 | C0023892 | Biliary cirrhosis | 1 | CTD_human |
| Hgene | CCL5 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | CCL5 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Hgene | CCL5 | C0034069 | Pulmonary Fibrosis | 1 | CTD_human |
| Hgene | CCL5 | C0086196 | Eczema, Infantile | 1 | CTD_human |
| Hgene | CCL5 | C0238065 | Secondary Biliary Cholangitis | 1 | CTD_human |
| Hgene | CCL5 | C0241910 | Autoimmune Chronic Hepatitis | 1 | CTD_human |
| Hgene | CCL5 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Hgene | CCL5 | C0524610 | Chronic Alcoholic Hepatitis | 1 | CTD_human |
| Hgene | CCL5 | C1298681 | Oxalosis | 1 | CTD_human |
| Hgene | CCL5 | C1704377 | Bright Disease | 1 | CTD_human |
| Hgene | CCL5 | C4551595 | Biliary Cirrhosis, Primary, 1 | 1 | CTD_human |
| Hgene | CCL5 | C4721507 | Alveolitis, Fibrosing | 1 | CTD_human |
| Tgene | C2931299 | ZAP70 deficiency | 5 | CTD_human;GENOMICS_ENGLAND;UNIPROT | |
| Tgene | C0085110 | Severe Combined Immunodeficiency | 2 | CTD_human;GENOMICS_ENGLAND | |
| Tgene | C4310768 | AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2 | 2 | CTD_human;GENOMICS_ENGLAND;UNIPROT | |
| Tgene | C0003257 | Antibody Deficiency Syndrome | 1 | CTD_human | |
| Tgene | C0021051 | Immunologic Deficiency Syndromes | 1 | CTD_human | |
| Tgene | C0242583 | Bare Lymphocyte Syndrome | 1 | CTD_human | |
| Tgene | C0700216 | Structural Clinical Interview for DSM-III | 1 | GENOMICS_ENGLAND | |
| Tgene | C2700553 | Omenn Syndrome | 1 | CTD_human | |
| Tgene | C2931320 | T cell immunodeficiency primary | 1 | CTD_human |
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