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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ATL2-NDRG2 (FusionGDB2 ID:HG64225TG57447)

Fusion Gene Summary for ATL2-NDRG2

Fusion gene summary

Fusion gene information	Fusion gene name: ATL2-NDRG2
	Fusion gene ID: hg64225tg57447
		Hgene	Tgene
	Gene symbol	ATL2	NDRG2
	Gene ID	64225	57447
	Gene name	atlastin GTPase 2	NDRG family member 2
	Synonyms	ARL3IP2\|ARL6IP2\|aip-2\|atlastin2	SYLD
	Cytomap	('ATL2')('NDRG2') 2p22.2-p22.1	14q11.2
	Type of gene	protein-coding	protein-coding
	Description	atlastin-2ADP-ribosylation factor-like protein 6-interacting protein 2ARL-6-interacting protein 2	protein NDRG2N-myc downstream regulator 2N-myc downstream-regulated gene 2 proteinNDR1-related protein NDR2cytoplasmic protein Ndr1syld709613 protein
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000332337, ENST00000378954, ENST00000402054, ENST00000406122, ENST00000419554, ENST00000452935, ENST00000486927, ENST00000539122, ENST00000546051,
Fusion gene scores	* DoF score	14 X 10 X 5=700	9 X 10 X 5=450
	# samples	16	11
	** MAII score	log2(16/700*10)=-2.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/450*10)=-2.03242147769238 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ATL2 [Title/Abstract] AND NDRG2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ATL2(38522877)-NDRG2(21493861), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ATL2	GO:0051260	protein homooligomerization	18270207

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	DB179338	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-

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Fusion Gene ORF analysis for ATL2-NDRG2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-5UTR	ENST00000332337	ENST00000298687	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000332337	ENST00000350792	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000332337	ENST00000360463	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000332337	ENST00000397847	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000332337	ENST00000397858	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000378954	ENST00000298687	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000378954	ENST00000350792	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000378954	ENST00000360463	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000378954	ENST00000397847	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000378954	ENST00000397858	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000402054	ENST00000298687	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000402054	ENST00000350792	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000402054	ENST00000360463	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000402054	ENST00000397847	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000402054	ENST00000397858	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000406122	ENST00000298687	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000406122	ENST00000350792	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000406122	ENST00000360463	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000406122	ENST00000397847	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000406122	ENST00000397858	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000419554	ENST00000298687	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000419554	ENST00000350792	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000419554	ENST00000360463	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000419554	ENST00000397847	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000419554	ENST00000397858	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000452935	ENST00000298687	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000452935	ENST00000350792	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000452935	ENST00000360463	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000452935	ENST00000397847	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000452935	ENST00000397858	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000486927	ENST00000298687	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000486927	ENST00000350792	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000486927	ENST00000360463	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000486927	ENST00000397847	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000486927	ENST00000397858	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000539122	ENST00000298687	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000539122	ENST00000350792	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000539122	ENST00000360463	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000539122	ENST00000397847	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000539122	ENST00000397858	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000546051	ENST00000298687	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000546051	ENST00000350792	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000546051	ENST00000360463	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000546051	ENST00000397847	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-5UTR	ENST00000546051	ENST00000397858	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000332337	ENST00000298684	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000332337	ENST00000397844	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000332337	ENST00000397851	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000332337	ENST00000397853	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000332337	ENST00000397855	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000332337	ENST00000397856	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000332337	ENST00000403829	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000332337	ENST00000553503	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000332337	ENST00000554104	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000332337	ENST00000554143	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000332337	ENST00000554277	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000332337	ENST00000555158	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000332337	ENST00000556147	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000378954	ENST00000298684	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000378954	ENST00000397844	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000378954	ENST00000397851	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000378954	ENST00000397853	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000378954	ENST00000397855	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000378954	ENST00000397856	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000378954	ENST00000403829	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000378954	ENST00000553503	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000378954	ENST00000554104	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000378954	ENST00000554143	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000378954	ENST00000554277	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000378954	ENST00000555158	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000378954	ENST00000556147	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000402054	ENST00000298684	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000402054	ENST00000397844	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000402054	ENST00000397851	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000402054	ENST00000397853	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000402054	ENST00000397855	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000402054	ENST00000397856	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000402054	ENST00000403829	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000402054	ENST00000553503	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000402054	ENST00000554104	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000402054	ENST00000554143	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000402054	ENST00000554277	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000402054	ENST00000555158	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000402054	ENST00000556147	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000406122	ENST00000298684	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000406122	ENST00000397844	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000406122	ENST00000397851	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000406122	ENST00000397853	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000406122	ENST00000397855	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000406122	ENST00000397856	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000406122	ENST00000403829	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000406122	ENST00000553503	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000406122	ENST00000554104	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000406122	ENST00000554143	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000406122	ENST00000554277	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000406122	ENST00000555158	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000406122	ENST00000556147	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000419554	ENST00000298684	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000419554	ENST00000397844	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000419554	ENST00000397851	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000419554	ENST00000397853	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000419554	ENST00000397855	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000419554	ENST00000397856	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000419554	ENST00000403829	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000419554	ENST00000553503	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000419554	ENST00000554104	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000419554	ENST00000554143	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000419554	ENST00000554277	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000419554	ENST00000555158	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000419554	ENST00000556147	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000452935	ENST00000298684	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000452935	ENST00000397844	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000452935	ENST00000397851	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000452935	ENST00000397853	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000452935	ENST00000397855	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000452935	ENST00000397856	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000452935	ENST00000403829	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000452935	ENST00000553503	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000452935	ENST00000554104	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000452935	ENST00000554143	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000452935	ENST00000554277	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000452935	ENST00000555158	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000452935	ENST00000556147	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000486927	ENST00000298684	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000486927	ENST00000397844	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000486927	ENST00000397851	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000486927	ENST00000397853	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000486927	ENST00000397855	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000486927	ENST00000397856	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000486927	ENST00000403829	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000486927	ENST00000553503	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000486927	ENST00000554104	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000486927	ENST00000554143	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000486927	ENST00000554277	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000486927	ENST00000555158	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000486927	ENST00000556147	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000539122	ENST00000298684	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000539122	ENST00000397844	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000539122	ENST00000397851	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000539122	ENST00000397853	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000539122	ENST00000397855	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000539122	ENST00000397856	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000539122	ENST00000403829	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000539122	ENST00000553503	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000539122	ENST00000554104	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000539122	ENST00000554143	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000539122	ENST00000554277	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000539122	ENST00000555158	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000539122	ENST00000556147	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000546051	ENST00000298684	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000546051	ENST00000397844	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000546051	ENST00000397851	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000546051	ENST00000397853	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000546051	ENST00000397855	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000546051	ENST00000397856	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000546051	ENST00000403829	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000546051	ENST00000553503	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000546051	ENST00000554104	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000546051	ENST00000554143	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000546051	ENST00000554277	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000546051	ENST00000555158	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-
intron-intron	ENST00000546051	ENST00000556147	ATL2	chr2	38522877	-	NDRG2	chr14	21493861	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for ATL2-NDRG2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

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Fusion Protein Features for ATL2-NDRG2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:38522877/:21493861)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ATL2-NDRG2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ATL2-NDRG2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ATL2-NDRG2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ATL2-NDRG2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene		C0007102	Malignant tumor of colon	1	CTD_human
Tgene		C0007787	Transient Ischemic Attack	1	CTD_human
Tgene		C0009375	Colonic Neoplasms	1	CTD_human
Tgene		C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Tgene		C0086543	Cataract	1	CTD_human
Tgene		C0472381	Posterior Circulation Transient Ischemic Attack	1	CTD_human
Tgene		C0524524	Pseudoaphakia	1	CTD_human
Tgene		C0751019	Carotid Circulation Transient Ischemic Attack	1	CTD_human
Tgene		C0751020	Transient Ischemic Attack, Vertebrobasilar Circulation	1	CTD_human
Tgene		C0751021	Crescendo Transient Ischemic Attacks	1	CTD_human
Tgene		C0751022	Brain Stem Ischemia, Transient	1	CTD_human
Tgene		C0917805	Transient Cerebral Ischemia	1	CTD_human
Tgene		C1510497	Lens Opacities	1	CTD_human
Tgene		C1527335	Transient Ischemic Attack, Anterior Circulation	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:ATL2-NDRG2 (FusionGDB2 ID:HG64225TG57447)

Fusion Gene Summary for ATL2-NDRG2

Fusion Gene ORF analysis for ATL2-NDRG2

Fusion Genomic Features for ATL2-NDRG2

Fusion Protein Features for ATL2-NDRG2

Fusion Gene Sequence for ATL2-NDRG2

Fusion Gene PPI Analysis for ATL2-NDRG2

Related Drugs for ATL2-NDRG2

Related Diseases for ATL2-NDRG2

Fusion Gene Studies
in Kim Lab