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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:SOS1-MAP4K3 (FusionGDB2 ID:HG6654TG8491) |
Fusion Gene Summary for SOS1-MAP4K3 |
Fusion gene summary |
Fusion gene information | Fusion gene name: SOS1-MAP4K3 | Fusion gene ID: hg6654tg8491 | Hgene | Tgene | Gene symbol | SOS1 | MAP4K3 | Gene ID | 6654 | 8491 |
Gene name | SOS Ras/Rac guanine nucleotide exchange factor 1 | mitogen-activated protein kinase kinase kinase kinase 3 | |
Synonyms | GF1|GGF1|GINGF|HGF|NS4|SOS-1 | GLK|MAPKKKK3|MEKKK 3|MEKKK3|RAB8IPL1 | |
Cytomap | ('SOS1')('MAP4K3') 2p22.1 | 2p22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | son of sevenless homolog 1gingival fibromatosis, hereditary, 1guanine nucleotide exchange factor | mitogen-activated protein kinase kinase kinase kinase 3MAPK/ERK kinase kinase kinase 3MEK kinase kinase 3germinal center kinase-like kinasegerminal center kinase-related protein kinase | |
Modification date | 20200327 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000395038, ENST00000402219, ENST00000426016, ENST00000428721, ENST00000472480, | ||
Fusion gene scores | * DoF score | 9 X 12 X 9=972 | 8 X 8 X 7=448 |
# samples | 14 | 11 | |
** MAII score | log2(14/972*10)=-2.79552948666081 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/448*10)=-2.02599520853294 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SOS1 [Title/Abstract] AND MAP4K3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | SOS1(39278285)-MAP4K3(39605264), # samples:3 SOS1(39283843)-MAP4K3(39605264), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | SOS1-MAP4K3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SOS1-MAP4K3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SOS1-MAP4K3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SOS1-MAP4K3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SOS1-MAP4K3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. SOS1-MAP4K3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. SOS1-MAP4K3 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MAP4K3 | GO:0006468 | protein phosphorylation | 9275185 |
Tgene | MAP4K3 | GO:0009411 | response to UV | 9275185 |
Tgene | MAP4K3 | GO:0034612 | response to tumor necrosis factor | 9275185 |
Tgene | MAP4K3 | GO:0035556 | intracellular signal transduction | 9275185 |
Fusion gene breakpoints across SOS1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across MAP4K3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-HU-8238-01A | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
ChimerDB4 | TGCT | TCGA-XE-AANR-01A | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
ChimerDB4 | TGCT | TCGA-XE-AANR | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
ChimerDB4 | THCA | TCGA-EL-A3H8-01A | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
ChimerDB4 | THCA | TCGA-EL-A3H8 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
Top |
Fusion Gene ORF analysis for SOS1-MAP4K3 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000395038 | ENST00000341681 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000395038 | ENST00000341681 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000395038 | ENST00000341681 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000395038 | ENST00000437545 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000395038 | ENST00000437545 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000395038 | ENST00000437545 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000395038 | ENST00000484274 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000395038 | ENST00000484274 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000395038 | ENST00000484274 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000395038 | ENST00000536018 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
5CDS-5UTR | ENST00000402219 | ENST00000341681 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000402219 | ENST00000341681 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000402219 | ENST00000341681 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000402219 | ENST00000437545 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000402219 | ENST00000437545 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000402219 | ENST00000437545 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000402219 | ENST00000484274 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000402219 | ENST00000484274 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000402219 | ENST00000484274 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000402219 | ENST00000536018 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
5CDS-5UTR | ENST00000426016 | ENST00000341681 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000426016 | ENST00000341681 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000426016 | ENST00000341681 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000426016 | ENST00000437545 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000426016 | ENST00000437545 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000426016 | ENST00000437545 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000426016 | ENST00000484274 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000426016 | ENST00000484274 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000426016 | ENST00000484274 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000426016 | ENST00000536018 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
5CDS-5UTR | ENST00000428721 | ENST00000341681 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000428721 | ENST00000341681 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000428721 | ENST00000341681 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000428721 | ENST00000437545 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000428721 | ENST00000437545 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000428721 | ENST00000437545 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000428721 | ENST00000484274 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000428721 | ENST00000484274 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-5UTR | ENST00000428721 | ENST00000484274 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-intron | ENST00000395038 | ENST00000474502 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
5CDS-intron | ENST00000395038 | ENST00000474502 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-intron | ENST00000395038 | ENST00000474502 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-intron | ENST00000395038 | ENST00000474502 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-intron | ENST00000395038 | ENST00000484274 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
5CDS-intron | ENST00000395038 | ENST00000536018 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-intron | ENST00000395038 | ENST00000536018 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-intron | ENST00000395038 | ENST00000536018 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-intron | ENST00000402219 | ENST00000474502 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
5CDS-intron | ENST00000402219 | ENST00000474502 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-intron | ENST00000402219 | ENST00000474502 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-intron | ENST00000402219 | ENST00000474502 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-intron | ENST00000402219 | ENST00000484274 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
5CDS-intron | ENST00000402219 | ENST00000536018 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-intron | ENST00000402219 | ENST00000536018 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-intron | ENST00000402219 | ENST00000536018 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-intron | ENST00000426016 | ENST00000474502 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
5CDS-intron | ENST00000426016 | ENST00000474502 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-intron | ENST00000426016 | ENST00000474502 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-intron | ENST00000426016 | ENST00000474502 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-intron | ENST00000426016 | ENST00000484274 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
5CDS-intron | ENST00000426016 | ENST00000536018 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-intron | ENST00000426016 | ENST00000536018 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-intron | ENST00000426016 | ENST00000536018 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-intron | ENST00000428721 | ENST00000474502 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-intron | ENST00000428721 | ENST00000474502 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-intron | ENST00000428721 | ENST00000474502 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-intron | ENST00000428721 | ENST00000536018 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-intron | ENST00000428721 | ENST00000536018 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
5CDS-intron | ENST00000428721 | ENST00000536018 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
Frame-shift | ENST00000426016 | ENST00000263881 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
Frame-shift | ENST00000426016 | ENST00000263881 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
Frame-shift | ENST00000426016 | ENST00000263881 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
Frame-shift | ENST00000426016 | ENST00000263881 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
Frame-shift | ENST00000426016 | ENST00000341681 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
Frame-shift | ENST00000426016 | ENST00000437545 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
Frame-shift | ENST00000428721 | ENST00000263881 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
Frame-shift | ENST00000428721 | ENST00000263881 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
Frame-shift | ENST00000428721 | ENST00000263881 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
In-frame | ENST00000395038 | ENST00000263881 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
In-frame | ENST00000395038 | ENST00000263881 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
In-frame | ENST00000395038 | ENST00000263881 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
In-frame | ENST00000395038 | ENST00000263881 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
In-frame | ENST00000395038 | ENST00000341681 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
In-frame | ENST00000395038 | ENST00000437545 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
In-frame | ENST00000402219 | ENST00000263881 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
In-frame | ENST00000402219 | ENST00000263881 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
In-frame | ENST00000402219 | ENST00000263881 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
In-frame | ENST00000402219 | ENST00000263881 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
In-frame | ENST00000402219 | ENST00000341681 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
In-frame | ENST00000402219 | ENST00000437545 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
intron-3CDS | ENST00000428721 | ENST00000263881 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
intron-3CDS | ENST00000428721 | ENST00000341681 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
intron-3CDS | ENST00000428721 | ENST00000437545 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
intron-3CDS | ENST00000472480 | ENST00000263881 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
intron-3CDS | ENST00000472480 | ENST00000263881 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
intron-3CDS | ENST00000472480 | ENST00000263881 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
intron-3CDS | ENST00000472480 | ENST00000263881 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
intron-3CDS | ENST00000472480 | ENST00000341681 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
intron-3CDS | ENST00000472480 | ENST00000437545 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
intron-5UTR | ENST00000428721 | ENST00000536018 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
intron-5UTR | ENST00000472480 | ENST00000341681 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
intron-5UTR | ENST00000472480 | ENST00000341681 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
intron-5UTR | ENST00000472480 | ENST00000341681 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
intron-5UTR | ENST00000472480 | ENST00000437545 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
intron-5UTR | ENST00000472480 | ENST00000437545 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
intron-5UTR | ENST00000472480 | ENST00000437545 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
intron-5UTR | ENST00000472480 | ENST00000484274 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
intron-5UTR | ENST00000472480 | ENST00000484274 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
intron-5UTR | ENST00000472480 | ENST00000484274 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
intron-5UTR | ENST00000472480 | ENST00000536018 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
intron-intron | ENST00000428721 | ENST00000474502 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
intron-intron | ENST00000428721 | ENST00000484274 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
intron-intron | ENST00000472480 | ENST00000474502 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
intron-intron | ENST00000472480 | ENST00000474502 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
intron-intron | ENST00000472480 | ENST00000474502 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
intron-intron | ENST00000472480 | ENST00000474502 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
intron-intron | ENST00000472480 | ENST00000484274 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - |
intron-intron | ENST00000472480 | ENST00000536018 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - |
intron-intron | ENST00000472480 | ENST00000536018 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - |
intron-intron | ENST00000472480 | ENST00000536018 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000402219 | SOS1 | chr2 | 39278285 | - | ENST00000263881 | MAP4K3 | chr2 | 39605264 | - | 4846 | 905 | 41 | 3493 | 1150 |
ENST00000395038 | SOS1 | chr2 | 39278285 | - | ENST00000263881 | MAP4K3 | chr2 | 39605264 | - | 4833 | 892 | 28 | 3480 | 1150 |
ENST00000402219 | SOS1 | chr2 | 39283843 | - | ENST00000263881 | MAP4K3 | chr2 | 39605264 | - | 4492 | 551 | 41 | 3139 | 1032 |
ENST00000395038 | SOS1 | chr2 | 39283843 | - | ENST00000263881 | MAP4K3 | chr2 | 39605264 | - | 4479 | 538 | 28 | 3126 | 1032 |
ENST00000402219 | SOS1 | chr2 | 39283842 | - | ENST00000263881 | MAP4K3 | chr2 | 39605264 | - | 4492 | 551 | 41 | 3139 | 1032 |
ENST00000395038 | SOS1 | chr2 | 39283842 | - | ENST00000263881 | MAP4K3 | chr2 | 39605264 | - | 4479 | 538 | 28 | 3126 | 1032 |
ENST00000402219 | SOS1 | chr2 | 39347477 | - | ENST00000263881 | MAP4K3 | chr2 | 39542529 | - | 3247 | 128 | 41 | 1894 | 617 |
ENST00000402219 | SOS1 | chr2 | 39347477 | - | ENST00000437545 | MAP4K3 | chr2 | 39542529 | - | 3172 | 128 | 41 | 1831 | 596 |
ENST00000402219 | SOS1 | chr2 | 39347477 | - | ENST00000341681 | MAP4K3 | chr2 | 39542529 | - | 3167 | 128 | 41 | 1831 | 596 |
ENST00000395038 | SOS1 | chr2 | 39347477 | - | ENST00000263881 | MAP4K3 | chr2 | 39542529 | - | 3234 | 115 | 28 | 1881 | 617 |
ENST00000395038 | SOS1 | chr2 | 39347477 | - | ENST00000437545 | MAP4K3 | chr2 | 39542529 | - | 3159 | 115 | 28 | 1818 | 596 |
ENST00000395038 | SOS1 | chr2 | 39347477 | - | ENST00000341681 | MAP4K3 | chr2 | 39542529 | - | 3154 | 115 | 28 | 1818 | 596 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000402219 | ENST00000263881 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - | 4.73E-05 | 0.9999528 |
ENST00000395038 | ENST00000263881 | SOS1 | chr2 | 39278285 | - | MAP4K3 | chr2 | 39605264 | - | 4.66E-05 | 0.9999534 |
ENST00000402219 | ENST00000263881 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - | 7.14E-05 | 0.9999286 |
ENST00000395038 | ENST00000263881 | SOS1 | chr2 | 39283843 | - | MAP4K3 | chr2 | 39605264 | - | 7.05E-05 | 0.9999294 |
ENST00000402219 | ENST00000263881 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - | 7.14E-05 | 0.9999286 |
ENST00000395038 | ENST00000263881 | SOS1 | chr2 | 39283842 | - | MAP4K3 | chr2 | 39605264 | - | 7.05E-05 | 0.9999294 |
ENST00000402219 | ENST00000263881 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - | 0.00035416 | 0.9996458 |
ENST00000402219 | ENST00000437545 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - | 0.000463059 | 0.999537 |
ENST00000402219 | ENST00000341681 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - | 0.000450549 | 0.99954945 |
ENST00000395038 | ENST00000263881 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - | 0.000349058 | 0.99965096 |
ENST00000395038 | ENST00000437545 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - | 0.000458856 | 0.99954116 |
ENST00000395038 | ENST00000341681 | SOS1 | chr2 | 39347477 | - | MAP4K3 | chr2 | 39542529 | - | 0.000447441 | 0.99955255 |
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Fusion Genomic Features for SOS1-MAP4K3 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for SOS1-MAP4K3 |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:39278285/chr2:39605264) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | MAP4K3 | chr2:39278285 | chr2:39605264 | ENST00000263881 | 0 | 34 | 556_867 | 32 | 895.0 | Domain | CNH | |
Tgene | MAP4K3 | chr2:39278285 | chr2:39605264 | ENST00000341681 | 0 | 33 | 556_867 | 32 | 874.0 | Domain | CNH | |
Tgene | MAP4K3 | chr2:39283842 | chr2:39605264 | ENST00000263881 | 0 | 34 | 556_867 | 32 | 895.0 | Domain | CNH | |
Tgene | MAP4K3 | chr2:39283842 | chr2:39605264 | ENST00000341681 | 0 | 33 | 556_867 | 32 | 874.0 | Domain | CNH | |
Tgene | MAP4K3 | chr2:39283843 | chr2:39605264 | ENST00000263881 | 0 | 34 | 556_867 | 32 | 895.0 | Domain | CNH | |
Tgene | MAP4K3 | chr2:39283843 | chr2:39605264 | ENST00000341681 | 0 | 33 | 556_867 | 32 | 874.0 | Domain | CNH | |
Tgene | MAP4K3 | chr2:39347477 | chr2:39542529 | ENST00000263881 | 11 | 34 | 556_867 | 306 | 895.0 | Domain | CNH | |
Tgene | MAP4K3 | chr2:39347477 | chr2:39542529 | ENST00000341681 | 11 | 33 | 556_867 | 306 | 874.0 | Domain | CNH |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | SOS1 | chr2:39278285 | chr2:39605264 | ENST00000402219 | - | 6 | 23 | 1258_1261 | 288 | 1334.0 | Compositional bias | Note=Poly-Pro |
Hgene | SOS1 | chr2:39278285 | chr2:39605264 | ENST00000426016 | - | 7 | 24 | 1258_1261 | 288 | 1334.0 | Compositional bias | Note=Poly-Pro |
Hgene | SOS1 | chr2:39283842 | chr2:39605264 | ENST00000402219 | - | 4 | 23 | 1258_1261 | 170 | 1334.0 | Compositional bias | Note=Poly-Pro |
Hgene | SOS1 | chr2:39283842 | chr2:39605264 | ENST00000426016 | - | 5 | 24 | 1258_1261 | 170 | 1334.0 | Compositional bias | Note=Poly-Pro |
Hgene | SOS1 | chr2:39283843 | chr2:39605264 | ENST00000402219 | - | 4 | 23 | 1258_1261 | 170 | 1334.0 | Compositional bias | Note=Poly-Pro |
Hgene | SOS1 | chr2:39283843 | chr2:39605264 | ENST00000426016 | - | 5 | 24 | 1258_1261 | 170 | 1334.0 | Compositional bias | Note=Poly-Pro |
Hgene | SOS1 | chr2:39347477 | chr2:39542529 | ENST00000402219 | - | 1 | 23 | 1258_1261 | 29 | 1334.0 | Compositional bias | Note=Poly-Pro |
Hgene | SOS1 | chr2:39347477 | chr2:39542529 | ENST00000426016 | - | 2 | 24 | 1258_1261 | 29 | 1334.0 | Compositional bias | Note=Poly-Pro |
Hgene | SOS1 | chr2:39278285 | chr2:39605264 | ENST00000402219 | - | 6 | 23 | 200_390 | 288 | 1334.0 | Domain | DH |
Hgene | SOS1 | chr2:39278285 | chr2:39605264 | ENST00000402219 | - | 6 | 23 | 444_548 | 288 | 1334.0 | Domain | PH |
Hgene | SOS1 | chr2:39278285 | chr2:39605264 | ENST00000402219 | - | 6 | 23 | 597_741 | 288 | 1334.0 | Domain | N-terminal Ras-GEF |
Hgene | SOS1 | chr2:39278285 | chr2:39605264 | ENST00000402219 | - | 6 | 23 | 780_1019 | 288 | 1334.0 | Domain | Ras-GEF |
Hgene | SOS1 | chr2:39278285 | chr2:39605264 | ENST00000426016 | - | 7 | 24 | 200_390 | 288 | 1334.0 | Domain | DH |
Hgene | SOS1 | chr2:39278285 | chr2:39605264 | ENST00000426016 | - | 7 | 24 | 444_548 | 288 | 1334.0 | Domain | PH |
Hgene | SOS1 | chr2:39278285 | chr2:39605264 | ENST00000426016 | - | 7 | 24 | 597_741 | 288 | 1334.0 | Domain | N-terminal Ras-GEF |
Hgene | SOS1 | chr2:39278285 | chr2:39605264 | ENST00000426016 | - | 7 | 24 | 780_1019 | 288 | 1334.0 | Domain | Ras-GEF |
Hgene | SOS1 | chr2:39283842 | chr2:39605264 | ENST00000402219 | - | 4 | 23 | 200_390 | 170 | 1334.0 | Domain | DH |
Hgene | SOS1 | chr2:39283842 | chr2:39605264 | ENST00000402219 | - | 4 | 23 | 444_548 | 170 | 1334.0 | Domain | PH |
Hgene | SOS1 | chr2:39283842 | chr2:39605264 | ENST00000402219 | - | 4 | 23 | 597_741 | 170 | 1334.0 | Domain | N-terminal Ras-GEF |
Hgene | SOS1 | chr2:39283842 | chr2:39605264 | ENST00000402219 | - | 4 | 23 | 780_1019 | 170 | 1334.0 | Domain | Ras-GEF |
Hgene | SOS1 | chr2:39283842 | chr2:39605264 | ENST00000426016 | - | 5 | 24 | 200_390 | 170 | 1334.0 | Domain | DH |
Hgene | SOS1 | chr2:39283842 | chr2:39605264 | ENST00000426016 | - | 5 | 24 | 444_548 | 170 | 1334.0 | Domain | PH |
Hgene | SOS1 | chr2:39283842 | chr2:39605264 | ENST00000426016 | - | 5 | 24 | 597_741 | 170 | 1334.0 | Domain | N-terminal Ras-GEF |
Hgene | SOS1 | chr2:39283842 | chr2:39605264 | ENST00000426016 | - | 5 | 24 | 780_1019 | 170 | 1334.0 | Domain | Ras-GEF |
Hgene | SOS1 | chr2:39283843 | chr2:39605264 | ENST00000402219 | - | 4 | 23 | 200_390 | 170 | 1334.0 | Domain | DH |
Hgene | SOS1 | chr2:39283843 | chr2:39605264 | ENST00000402219 | - | 4 | 23 | 444_548 | 170 | 1334.0 | Domain | PH |
Hgene | SOS1 | chr2:39283843 | chr2:39605264 | ENST00000402219 | - | 4 | 23 | 597_741 | 170 | 1334.0 | Domain | N-terminal Ras-GEF |
Hgene | SOS1 | chr2:39283843 | chr2:39605264 | ENST00000402219 | - | 4 | 23 | 780_1019 | 170 | 1334.0 | Domain | Ras-GEF |
Hgene | SOS1 | chr2:39283843 | chr2:39605264 | ENST00000426016 | - | 5 | 24 | 200_390 | 170 | 1334.0 | Domain | DH |
Hgene | SOS1 | chr2:39283843 | chr2:39605264 | ENST00000426016 | - | 5 | 24 | 444_548 | 170 | 1334.0 | Domain | PH |
Hgene | SOS1 | chr2:39283843 | chr2:39605264 | ENST00000426016 | - | 5 | 24 | 597_741 | 170 | 1334.0 | Domain | N-terminal Ras-GEF |
Hgene | SOS1 | chr2:39283843 | chr2:39605264 | ENST00000426016 | - | 5 | 24 | 780_1019 | 170 | 1334.0 | Domain | Ras-GEF |
Hgene | SOS1 | chr2:39347477 | chr2:39542529 | ENST00000402219 | - | 1 | 23 | 200_390 | 29 | 1334.0 | Domain | DH |
Hgene | SOS1 | chr2:39347477 | chr2:39542529 | ENST00000402219 | - | 1 | 23 | 444_548 | 29 | 1334.0 | Domain | PH |
Hgene | SOS1 | chr2:39347477 | chr2:39542529 | ENST00000402219 | - | 1 | 23 | 597_741 | 29 | 1334.0 | Domain | N-terminal Ras-GEF |
Hgene | SOS1 | chr2:39347477 | chr2:39542529 | ENST00000402219 | - | 1 | 23 | 780_1019 | 29 | 1334.0 | Domain | Ras-GEF |
Hgene | SOS1 | chr2:39347477 | chr2:39542529 | ENST00000426016 | - | 2 | 24 | 200_390 | 29 | 1334.0 | Domain | DH |
Hgene | SOS1 | chr2:39347477 | chr2:39542529 | ENST00000426016 | - | 2 | 24 | 444_548 | 29 | 1334.0 | Domain | PH |
Hgene | SOS1 | chr2:39347477 | chr2:39542529 | ENST00000426016 | - | 2 | 24 | 597_741 | 29 | 1334.0 | Domain | N-terminal Ras-GEF |
Hgene | SOS1 | chr2:39347477 | chr2:39542529 | ENST00000426016 | - | 2 | 24 | 780_1019 | 29 | 1334.0 | Domain | Ras-GEF |
Tgene | MAP4K3 | chr2:39278285 | chr2:39605264 | ENST00000263881 | 0 | 34 | 16_273 | 32 | 895.0 | Domain | Protein kinase | |
Tgene | MAP4K3 | chr2:39278285 | chr2:39605264 | ENST00000341681 | 0 | 33 | 16_273 | 32 | 874.0 | Domain | Protein kinase | |
Tgene | MAP4K3 | chr2:39283842 | chr2:39605264 | ENST00000263881 | 0 | 34 | 16_273 | 32 | 895.0 | Domain | Protein kinase | |
Tgene | MAP4K3 | chr2:39283842 | chr2:39605264 | ENST00000341681 | 0 | 33 | 16_273 | 32 | 874.0 | Domain | Protein kinase | |
Tgene | MAP4K3 | chr2:39283843 | chr2:39605264 | ENST00000263881 | 0 | 34 | 16_273 | 32 | 895.0 | Domain | Protein kinase | |
Tgene | MAP4K3 | chr2:39283843 | chr2:39605264 | ENST00000341681 | 0 | 33 | 16_273 | 32 | 874.0 | Domain | Protein kinase | |
Tgene | MAP4K3 | chr2:39347477 | chr2:39542529 | ENST00000263881 | 11 | 34 | 16_273 | 306 | 895.0 | Domain | Protein kinase | |
Tgene | MAP4K3 | chr2:39347477 | chr2:39542529 | ENST00000341681 | 11 | 33 | 16_273 | 306 | 874.0 | Domain | Protein kinase | |
Tgene | MAP4K3 | chr2:39278285 | chr2:39605264 | ENST00000263881 | 0 | 34 | 22_30 | 32 | 895.0 | Nucleotide binding | ATP | |
Tgene | MAP4K3 | chr2:39278285 | chr2:39605264 | ENST00000341681 | 0 | 33 | 22_30 | 32 | 874.0 | Nucleotide binding | ATP | |
Tgene | MAP4K3 | chr2:39283842 | chr2:39605264 | ENST00000263881 | 0 | 34 | 22_30 | 32 | 895.0 | Nucleotide binding | ATP | |
Tgene | MAP4K3 | chr2:39283842 | chr2:39605264 | ENST00000341681 | 0 | 33 | 22_30 | 32 | 874.0 | Nucleotide binding | ATP | |
Tgene | MAP4K3 | chr2:39283843 | chr2:39605264 | ENST00000263881 | 0 | 34 | 22_30 | 32 | 895.0 | Nucleotide binding | ATP | |
Tgene | MAP4K3 | chr2:39283843 | chr2:39605264 | ENST00000341681 | 0 | 33 | 22_30 | 32 | 874.0 | Nucleotide binding | ATP | |
Tgene | MAP4K3 | chr2:39347477 | chr2:39542529 | ENST00000263881 | 11 | 34 | 22_30 | 306 | 895.0 | Nucleotide binding | ATP | |
Tgene | MAP4K3 | chr2:39347477 | chr2:39542529 | ENST00000341681 | 11 | 33 | 22_30 | 306 | 874.0 | Nucleotide binding | ATP |
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Fusion Gene Sequence for SOS1-MAP4K3 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>85262_85262_1_SOS1-MAP4K3_SOS1_chr2_39278285_ENST00000395038_MAP4K3_chr2_39605264_ENST00000263881_length(transcript)=4833nt_BP=892nt CCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGCCCAAGTGGCGGGG ACTACTGGTGCCTGCGCTGAAAAAGGTCCAGGGGCAAGTTCATCCTACTCTCGAGTCTAATGATGATGCTCTTCAGTATGTTGAAGAATT AATTTTGCAATTATTAAATATGCTATGCCAAGCTCAGCCCCGAAGTGCTTCAGATGTAGAGGAACGTGTTCAAAAAAGTTTCCCTCATCC AATTGATAAATGGGCAATAGCTGATGCCCAATCAGCTATTGAAAAGAGGAAGCGAAGAAACCCTTTATCTCTCCCAGTAGAAAAAATTCA TCCTTTATTAAAGGAGGTCCTAGGTTATAAAATTGACCACCAGGTTTCTGTTTACATAGTAGCAGTCTTAGAATACATTTCTGCAGACAT TTTAAAGCTGGTTGGGAATTATGTAAGAAATATACGGCATTATGAAATTACAAAACAAGATATTAAAGTGGCAATGTGTGCTGACAAGGT ATTGATGGATATGTTTCATCAAGATGTAGAAGATATTAATATATTATCTTTAACTGACGAAGAGCCTTCCACCTCAGGAGAACAAACTTA CTATGATTTGGTAAAAGCATTTATGGCAGAAATTCGACAATATATAAGGGAACTAAATCTAATTATAAAAGTTTTTAGAGAGCCCTTTGT CTCCAATTCAAAATTGTTTTCAGCTAATGATGTAGAAAATATATTTAGTCGCATAGTAGATATACATGAACTTAGTGTAAAGTTACTGGG CCATATAGAAGATACAGTAGAAATGACAGATGAAGGCAGTCCCCATCCACTAGTAGGAAGCTGCTTTGAAGACTTAGCAGAGGCACGGAA TGTTAACACTGGTGAATTAGCAGCAATTAAAGTAATAAAATTGGAACCAGGAGAAGACTTTGCAGTTGTGCAGCAAGAAATTATTATGAT GAAAGACTGTAAACACCCAAATATTGTTGCTTATTTTGGAAGCTATCTCAGGCGAGATAAGCTTTGGATTTGCATGGAGTTTTGTGGAGG TGGTTCTTTACAGGATATTTATCACGTAACTGGACCTCTGTCAGAACTGCAAATTGCATATGTTAGCAGAGAAACACTGCAGGGATTATA TTATCTTCACAGTAAAGGAAAAATGCACAGAGATATAAAGGGAGCTAACATTCTATTAACGGATAATGGTCATGTGAAATTGGCTGATTT TGGAGTATCTGCACAGATAACAGCTACAATTGCCAAACGGAAGTCTTTCATTGGCACACCATATTGGATGGCTCCAGAAGTTGCAGCTGT TGAGAGGAAGGGGGGTTACAATCAACTCTGTGATCTCTGGGCAGTGGGAATCACTGCCATAGAACTTGCAGAGCTTCAGCCTCCTATGTT TGACTTACACCCAATGAGAGCATTATTTCTAATGACAAAAAGCAATTTTCAGCCTCCTAAACTAAAGGATAAAATGAAATGGTCAAATAG TTTTCATCACTTTGTGAAAATGGCACTTACCAAAAATCCGAAAAAAAGACCTACTGCTGAAAAATTATTACAGCATCCTTTTGTAACACA ACATTTGACACGGTCTTTGGCAATCGAGCTGTTGGATAAAGTAAATAATCCAGATCATTCCACTTACCATGATTTCGATGATGATGATCC TGAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAGAAGAAAAAACACGCTCAGAGATAACCTTTGGCCA AGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTCCCGACAGTGATGGTTTTTTGGACAGTTCAGAAGAAAT ATACTACACTGCAAGATCTAATCTGGATCTGCAACTGGAATATGGACAAGGACACCAAGGTGGTTACTTTTTAGGTGCAAACAAGAGTCT TCTCAAGTCTGTTGAAGAAGAATTGCATCAGCGAGGACACGTCGCACATTTAGAAGATGATGAAGGAGATGATGATGAATCTAAACACTC AACTCTGAAAGCAAAAATTCCACCTCCTTTGCCACCAAAGCCTAAGTCTATCTTCATACCACAGGAAATGCATTCTACTGAGGATGAAAA TCAAGGAACAATCAAGAGATGTCCCATGTCAGGGAGCCCAGCAAAGCCATCCCAAGTTCCACCTAGACCACCACCTCCCAGATTACCCCC ACACAAACCTGTTGCCTTAGGAAATGGAATGAGCTCCTTCCAGTTAAATGGTGAACGAGATGGCTCATTATGTCAACAACAGAATGAACA TAGAGGCACAAACCTTTCAAGAAAAGAAAAGAAAGATGTACCAAAGCCTATTAGTAATGGTCTTCCTCCAACACCTAAAGTGCATATGGG TGCATGTTTTTCAAAAGTTTTTAATGGGTGTCCCTTGAAAATTCACTGTGCATCATCATGGATAAACCCAGATACAAGAGATCAGTACTT GATATTTGGTGCCGAAGAAGGGATTTATACCCTCAATCTTAATGAACTTCATGAAACATCAATGGAACAGCTATTCCCTCGAAGGTGTAC ATGGTTGTATGTAATGAACAATTGCTTGCTATCAATATCTGGTAAAGCTTCTCAGCTTTATTCCCATAATTTACCAGGGCTTTTTGATTA TGCAAGACAAATGCAAAAGTTACCTGTTGCTATTCCAGCACACAAACTCCCTGACAGAATACTGCCAAGGAAATTTTCTGTATCAGCAAA AATCCCTGAAACCAAATGGTGCCAGAAGTGTTGTGTTGTAAGAAATCCTTACACGGGCCATAAATACCTATGTGGAGCACTTCAGACTAG CATTGTTCTATTAGAATGGGTTGAACCAATGCAGAAATTTATGTTAATTAAGCACATAGATTTTCCTATACCATGTCCACTTAGAATGTT TGAAATGCTGGTAGTTCCTGAACAGGAGTACCCTTTAGTTTGTGTTGGTGTCAGTAGAGGTAGAGACTTCAACCAAGTGGTTCGATTTGA GACGGTCAATCCAAATTCTACCTCTTCATGGTTTACAGAATCAGATACCCCACAGACAAATGTTACTCATGTAACCCAACTGGAGAGAGA TACCATCCTTGTATGCTTGGACTGTTGTATAAAAATAGTAAATCTCCAAGGAAGATTAAAATCTAGCAGGAAATTGTCATCAGAACTCAC CTTTGATTTCCAGATTGAATCAATAGTGTGCCTACAAGACAGTGTGCTAGCTTTCTGGAAACATGGAATGCAAGGTAGAAGTTTTAGATC TAATGAGGTAACACAAGAAATTTCAGATAGCACAAGAATTTTCAGGCTGCTTGGATCTGACAGGGTCGTGGTTTTGGAAAGTAGGCCAAC TGATAACCCCACAGCAAATAGCAATTTGTACATCCTGGCGGGTCATGAAAACAGTTACTGAGAATTGTTGTGCTTTGACAGTTAACTCTA GAAAGAAAGAACACTACCACTGCAACATTAATGGATGCTTGAAGCTGTACAAAAGCTGCAGTAACCTGTCTTCAGTTACTTTGTAATTTA TTGTGGCATGAGATAAGATGGGGAAAATTTTGTTTTAAGTGGTATGGATATATTTAGCATATTGAACCACACAAGTGCTTAATTCATTGT TATGTAATCTTTGTACATATAGGCAGTATTTTTTCTGTGAAACTTCATATTGCTGAAGACATACACTAAGAATTTATGTAGATAATGTAC TTTTATGAGATGTACAAGTAAGTGTCTTATCTGTACAGATGTAAATGTTGATGAAAATGCAATTGGGGTTAATATTTTAAGAATTCTTTA GTATATTCTTGGGTGTGGCTATATTACAAAATGGGATGCTGGCAATGAAACAATACATTTAACACTATTGTATTTTTATTATATGTAATT TAGTAATATGAATATAAATCTTGTAACTTTTAAAATTGTAATGGAGGCTGTAATCATTTTATAATCTTTTTAATTTTAATGCAAGTACAC TGGTGTTTATATTTGCACAAAGTATTGATATGTGATGTATTAAGTCACAAAAGTAAGCTGTGACATTGTCTATAAGCATTTGGCTCCACA AATGTATTTGGATTGTTTTCTATGTGAAGCAAACCAATTATAATTAACCACATGTTGTAGTAACTGGTCTTTTTATATTTAAGCAGAATC CTGTAAGATTGCTTGTCTTTGCTTAAAAACAATACCTTTGAACATTTTTGAATCACAGAATAGCGGTACCATGATAGAATACTGCAATTG TGGTCAGAATTACAGTATGCACAAAGAATTAATTAGCATTATTAAAGAGTCCTCACTAAACATTTCATATGATCACACTGAAGAACTGTA ACATTCCATAGAGTGAAGTGGTTCAAATTTCTCTTGGAATTTTTACTTTTGTTGGCCTTATTTTATGATCCTTTTCATATTTCTTTTGAC TTAGAGTATTAATACATGGCCAAAATAATTTAGTTACTACCTCATACAAACAATATAATGGTTACTACACATCACAGGAACTTAGTTTTG GTTTAAGTCATTTTTGATTGCTTTTTTCCAATGGAATATGTATATACCAGGTTTTAGCAAAATGCACACTTTTGGCTCTTTTTGGTATAT GTTCTTTATATTTTAATGTGAGTATATACACTAAGAACAAACTAAATTGTGATTTATGATCTTCATTTATTTTAATGATAATGGTTTTAA >85262_85262_1_SOS1-MAP4K3_SOS1_chr2_39278285_ENST00000395038_MAP4K3_chr2_39605264_ENST00000263881_length(amino acids)=1150AA_BP=288 MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADA QSAIEKRKRRNPLSLPVEKIHPLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDV EDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSANDVENIFSRIVDIHELSVKLLGHIEDTVEMT DEGSPHPLVGSCFEDLAEARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHV TGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQL CDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIE LLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLD LQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPM SGSPAKPSQVPPRPPPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNG CPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPV AIPAHKLPDRILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQE YPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIV -------------------------------------------------------------- >85262_85262_2_SOS1-MAP4K3_SOS1_chr2_39278285_ENST00000402219_MAP4K3_chr2_39605264_ENST00000263881_length(transcript)=4846nt_BP=905nt CCGCCGCCCCTCTCCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGC CCAAGTGGCGGGGACTACTGGTGCCTGCGCTGAAAAAGGTCCAGGGGCAAGTTCATCCTACTCTCGAGTCTAATGATGATGCTCTTCAGT ATGTTGAAGAATTAATTTTGCAATTATTAAATATGCTATGCCAAGCTCAGCCCCGAAGTGCTTCAGATGTAGAGGAACGTGTTCAAAAAA GTTTCCCTCATCCAATTGATAAATGGGCAATAGCTGATGCCCAATCAGCTATTGAAAAGAGGAAGCGAAGAAACCCTTTATCTCTCCCAG TAGAAAAAATTCATCCTTTATTAAAGGAGGTCCTAGGTTATAAAATTGACCACCAGGTTTCTGTTTACATAGTAGCAGTCTTAGAATACA TTTCTGCAGACATTTTAAAGCTGGTTGGGAATTATGTAAGAAATATACGGCATTATGAAATTACAAAACAAGATATTAAAGTGGCAATGT GTGCTGACAAGGTATTGATGGATATGTTTCATCAAGATGTAGAAGATATTAATATATTATCTTTAACTGACGAAGAGCCTTCCACCTCAG GAGAACAAACTTACTATGATTTGGTAAAAGCATTTATGGCAGAAATTCGACAATATATAAGGGAACTAAATCTAATTATAAAAGTTTTTA GAGAGCCCTTTGTCTCCAATTCAAAATTGTTTTCAGCTAATGATGTAGAAAATATATTTAGTCGCATAGTAGATATACATGAACTTAGTG TAAAGTTACTGGGCCATATAGAAGATACAGTAGAAATGACAGATGAAGGCAGTCCCCATCCACTAGTAGGAAGCTGCTTTGAAGACTTAG CAGAGGCACGGAATGTTAACACTGGTGAATTAGCAGCAATTAAAGTAATAAAATTGGAACCAGGAGAAGACTTTGCAGTTGTGCAGCAAG AAATTATTATGATGAAAGACTGTAAACACCCAAATATTGTTGCTTATTTTGGAAGCTATCTCAGGCGAGATAAGCTTTGGATTTGCATGG AGTTTTGTGGAGGTGGTTCTTTACAGGATATTTATCACGTAACTGGACCTCTGTCAGAACTGCAAATTGCATATGTTAGCAGAGAAACAC TGCAGGGATTATATTATCTTCACAGTAAAGGAAAAATGCACAGAGATATAAAGGGAGCTAACATTCTATTAACGGATAATGGTCATGTGA AATTGGCTGATTTTGGAGTATCTGCACAGATAACAGCTACAATTGCCAAACGGAAGTCTTTCATTGGCACACCATATTGGATGGCTCCAG AAGTTGCAGCTGTTGAGAGGAAGGGGGGTTACAATCAACTCTGTGATCTCTGGGCAGTGGGAATCACTGCCATAGAACTTGCAGAGCTTC AGCCTCCTATGTTTGACTTACACCCAATGAGAGCATTATTTCTAATGACAAAAAGCAATTTTCAGCCTCCTAAACTAAAGGATAAAATGA AATGGTCAAATAGTTTTCATCACTTTGTGAAAATGGCACTTACCAAAAATCCGAAAAAAAGACCTACTGCTGAAAAATTATTACAGCATC CTTTTGTAACACAACATTTGACACGGTCTTTGGCAATCGAGCTGTTGGATAAAGTAAATAATCCAGATCATTCCACTTACCATGATTTCG ATGATGATGATCCTGAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAGAAGAAAAAACACGCTCAGAGA TAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTCCCGACAGTGATGGTTTTTTGGACA GTTCAGAAGAAATATACTACACTGCAAGATCTAATCTGGATCTGCAACTGGAATATGGACAAGGACACCAAGGTGGTTACTTTTTAGGTG CAAACAAGAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATCAGCGAGGACACGTCGCACATTTAGAAGATGATGAAGGAGATGATGATG AATCTAAACACTCAACTCTGAAAGCAAAAATTCCACCTCCTTTGCCACCAAAGCCTAAGTCTATCTTCATACCACAGGAAATGCATTCTA CTGAGGATGAAAATCAAGGAACAATCAAGAGATGTCCCATGTCAGGGAGCCCAGCAAAGCCATCCCAAGTTCCACCTAGACCACCACCTC CCAGATTACCCCCACACAAACCTGTTGCCTTAGGAAATGGAATGAGCTCCTTCCAGTTAAATGGTGAACGAGATGGCTCATTATGTCAAC AACAGAATGAACATAGAGGCACAAACCTTTCAAGAAAAGAAAAGAAAGATGTACCAAAGCCTATTAGTAATGGTCTTCCTCCAACACCTA AAGTGCATATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGTGTCCCTTGAAAATTCACTGTGCATCATCATGGATAAACCCAGATACAA GAGATCAGTACTTGATATTTGGTGCCGAAGAAGGGATTTATACCCTCAATCTTAATGAACTTCATGAAACATCAATGGAACAGCTATTCC CTCGAAGGTGTACATGGTTGTATGTAATGAACAATTGCTTGCTATCAATATCTGGTAAAGCTTCTCAGCTTTATTCCCATAATTTACCAG GGCTTTTTGATTATGCAAGACAAATGCAAAAGTTACCTGTTGCTATTCCAGCACACAAACTCCCTGACAGAATACTGCCAAGGAAATTTT CTGTATCAGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGTGTTGTGTTGTAAGAAATCCTTACACGGGCCATAAATACCTATGTGGAG CACTTCAGACTAGCATTGTTCTATTAGAATGGGTTGAACCAATGCAGAAATTTATGTTAATTAAGCACATAGATTTTCCTATACCATGTC CACTTAGAATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGTACCCTTTAGTTTGTGTTGGTGTCAGTAGAGGTAGAGACTTCAACCAAG TGGTTCGATTTGAGACGGTCAATCCAAATTCTACCTCTTCATGGTTTACAGAATCAGATACCCCACAGACAAATGTTACTCATGTAACCC AACTGGAGAGAGATACCATCCTTGTATGCTTGGACTGTTGTATAAAAATAGTAAATCTCCAAGGAAGATTAAAATCTAGCAGGAAATTGT CATCAGAACTCACCTTTGATTTCCAGATTGAATCAATAGTGTGCCTACAAGACAGTGTGCTAGCTTTCTGGAAACATGGAATGCAAGGTA GAAGTTTTAGATCTAATGAGGTAACACAAGAAATTTCAGATAGCACAAGAATTTTCAGGCTGCTTGGATCTGACAGGGTCGTGGTTTTGG AAAGTAGGCCAACTGATAACCCCACAGCAAATAGCAATTTGTACATCCTGGCGGGTCATGAAAACAGTTACTGAGAATTGTTGTGCTTTG ACAGTTAACTCTAGAAAGAAAGAACACTACCACTGCAACATTAATGGATGCTTGAAGCTGTACAAAAGCTGCAGTAACCTGTCTTCAGTT ACTTTGTAATTTATTGTGGCATGAGATAAGATGGGGAAAATTTTGTTTTAAGTGGTATGGATATATTTAGCATATTGAACCACACAAGTG CTTAATTCATTGTTATGTAATCTTTGTACATATAGGCAGTATTTTTTCTGTGAAACTTCATATTGCTGAAGACATACACTAAGAATTTAT GTAGATAATGTACTTTTATGAGATGTACAAGTAAGTGTCTTATCTGTACAGATGTAAATGTTGATGAAAATGCAATTGGGGTTAATATTT TAAGAATTCTTTAGTATATTCTTGGGTGTGGCTATATTACAAAATGGGATGCTGGCAATGAAACAATACATTTAACACTATTGTATTTTT ATTATATGTAATTTAGTAATATGAATATAAATCTTGTAACTTTTAAAATTGTAATGGAGGCTGTAATCATTTTATAATCTTTTTAATTTT AATGCAAGTACACTGGTGTTTATATTTGCACAAAGTATTGATATGTGATGTATTAAGTCACAAAAGTAAGCTGTGACATTGTCTATAAGC ATTTGGCTCCACAAATGTATTTGGATTGTTTTCTATGTGAAGCAAACCAATTATAATTAACCACATGTTGTAGTAACTGGTCTTTTTATA TTTAAGCAGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAACAATACCTTTGAACATTTTTGAATCACAGAATAGCGGTACCATGATAG AATACTGCAATTGTGGTCAGAATTACAGTATGCACAAAGAATTAATTAGCATTATTAAAGAGTCCTCACTAAACATTTCATATGATCACA CTGAAGAACTGTAACATTCCATAGAGTGAAGTGGTTCAAATTTCTCTTGGAATTTTTACTTTTGTTGGCCTTATTTTATGATCCTTTTCA TATTTCTTTTGACTTAGAGTATTAATACATGGCCAAAATAATTTAGTTACTACCTCATACAAACAATATAATGGTTACTACACATCACAG GAACTTAGTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCCAATGGAATATGTATATACCAGGTTTTAGCAAAATGCACACTTTTGGCT CTTTTTGGTATATGTTCTTTATATTTTAATGTGAGTATATACACTAAGAACAAACTAAATTGTGATTTATGATCTTCATTTATTTTAATG >85262_85262_2_SOS1-MAP4K3_SOS1_chr2_39278285_ENST00000402219_MAP4K3_chr2_39605264_ENST00000263881_length(amino acids)=1150AA_BP=288 MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADA QSAIEKRKRRNPLSLPVEKIHPLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDV EDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSANDVENIFSRIVDIHELSVKLLGHIEDTVEMT DEGSPHPLVGSCFEDLAEARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHV TGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQL CDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIE LLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLD LQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPM SGSPAKPSQVPPRPPPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNG CPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPV AIPAHKLPDRILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQE YPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIV -------------------------------------------------------------- >85262_85262_3_SOS1-MAP4K3_SOS1_chr2_39283842_ENST00000395038_MAP4K3_chr2_39605264_ENST00000263881_length(transcript)=4479nt_BP=538nt CCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGCCCAAGTGGCGGGG ACTACTGGTGCCTGCGCTGAAAAAGGTCCAGGGGCAAGTTCATCCTACTCTCGAGTCTAATGATGATGCTCTTCAGTATGTTGAAGAATT AATTTTGCAATTATTAAATATGCTATGCCAAGCTCAGCCCCGAAGTGCTTCAGATGTAGAGGAACGTGTTCAAAAAAGTTTCCCTCATCC AATTGATAAATGGGCAATAGCTGATGCCCAATCAGCTATTGAAAAGAGGAAGCGAAGAAACCCTTTATCTCTCCCAGTAGAAAAAATTCA TCCTTTATTAAAGGAGGTCCTAGGTTATAAAATTGACCACCAGGTTTCTGTTTACATAGTAGCAGTCTTAGAATACATTTCTGCAGACAT TTTAAAGCTGGTTGGGAATTATGTAAGAAATATACGGCATTATGAAATTACAAAACAAGATATTAAAGTGGCAATGTGTGCTGACAAGGC ACGGAATGTTAACACTGGTGAATTAGCAGCAATTAAAGTAATAAAATTGGAACCAGGAGAAGACTTTGCAGTTGTGCAGCAAGAAATTAT TATGATGAAAGACTGTAAACACCCAAATATTGTTGCTTATTTTGGAAGCTATCTCAGGCGAGATAAGCTTTGGATTTGCATGGAGTTTTG TGGAGGTGGTTCTTTACAGGATATTTATCACGTAACTGGACCTCTGTCAGAACTGCAAATTGCATATGTTAGCAGAGAAACACTGCAGGG ATTATATTATCTTCACAGTAAAGGAAAAATGCACAGAGATATAAAGGGAGCTAACATTCTATTAACGGATAATGGTCATGTGAAATTGGC TGATTTTGGAGTATCTGCACAGATAACAGCTACAATTGCCAAACGGAAGTCTTTCATTGGCACACCATATTGGATGGCTCCAGAAGTTGC AGCTGTTGAGAGGAAGGGGGGTTACAATCAACTCTGTGATCTCTGGGCAGTGGGAATCACTGCCATAGAACTTGCAGAGCTTCAGCCTCC TATGTTTGACTTACACCCAATGAGAGCATTATTTCTAATGACAAAAAGCAATTTTCAGCCTCCTAAACTAAAGGATAAAATGAAATGGTC AAATAGTTTTCATCACTTTGTGAAAATGGCACTTACCAAAAATCCGAAAAAAAGACCTACTGCTGAAAAATTATTACAGCATCCTTTTGT AACACAACATTTGACACGGTCTTTGGCAATCGAGCTGTTGGATAAAGTAAATAATCCAGATCATTCCACTTACCATGATTTCGATGATGA TGATCCTGAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAGAAGAAAAAACACGCTCAGAGATAACCTT TGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTCCCGACAGTGATGGTTTTTTGGACAGTTCAGA AGAAATATACTACACTGCAAGATCTAATCTGGATCTGCAACTGGAATATGGACAAGGACACCAAGGTGGTTACTTTTTAGGTGCAAACAA GAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATCAGCGAGGACACGTCGCACATTTAGAAGATGATGAAGGAGATGATGATGAATCTAA ACACTCAACTCTGAAAGCAAAAATTCCACCTCCTTTGCCACCAAAGCCTAAGTCTATCTTCATACCACAGGAAATGCATTCTACTGAGGA TGAAAATCAAGGAACAATCAAGAGATGTCCCATGTCAGGGAGCCCAGCAAAGCCATCCCAAGTTCCACCTAGACCACCACCTCCCAGATT ACCCCCACACAAACCTGTTGCCTTAGGAAATGGAATGAGCTCCTTCCAGTTAAATGGTGAACGAGATGGCTCATTATGTCAACAACAGAA TGAACATAGAGGCACAAACCTTTCAAGAAAAGAAAAGAAAGATGTACCAAAGCCTATTAGTAATGGTCTTCCTCCAACACCTAAAGTGCA TATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGTGTCCCTTGAAAATTCACTGTGCATCATCATGGATAAACCCAGATACAAGAGATCA GTACTTGATATTTGGTGCCGAAGAAGGGATTTATACCCTCAATCTTAATGAACTTCATGAAACATCAATGGAACAGCTATTCCCTCGAAG GTGTACATGGTTGTATGTAATGAACAATTGCTTGCTATCAATATCTGGTAAAGCTTCTCAGCTTTATTCCCATAATTTACCAGGGCTTTT TGATTATGCAAGACAAATGCAAAAGTTACCTGTTGCTATTCCAGCACACAAACTCCCTGACAGAATACTGCCAAGGAAATTTTCTGTATC AGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGTGTTGTGTTGTAAGAAATCCTTACACGGGCCATAAATACCTATGTGGAGCACTTCA GACTAGCATTGTTCTATTAGAATGGGTTGAACCAATGCAGAAATTTATGTTAATTAAGCACATAGATTTTCCTATACCATGTCCACTTAG AATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGTACCCTTTAGTTTGTGTTGGTGTCAGTAGAGGTAGAGACTTCAACCAAGTGGTTCG ATTTGAGACGGTCAATCCAAATTCTACCTCTTCATGGTTTACAGAATCAGATACCCCACAGACAAATGTTACTCATGTAACCCAACTGGA GAGAGATACCATCCTTGTATGCTTGGACTGTTGTATAAAAATAGTAAATCTCCAAGGAAGATTAAAATCTAGCAGGAAATTGTCATCAGA ACTCACCTTTGATTTCCAGATTGAATCAATAGTGTGCCTACAAGACAGTGTGCTAGCTTTCTGGAAACATGGAATGCAAGGTAGAAGTTT TAGATCTAATGAGGTAACACAAGAAATTTCAGATAGCACAAGAATTTTCAGGCTGCTTGGATCTGACAGGGTCGTGGTTTTGGAAAGTAG GCCAACTGATAACCCCACAGCAAATAGCAATTTGTACATCCTGGCGGGTCATGAAAACAGTTACTGAGAATTGTTGTGCTTTGACAGTTA ACTCTAGAAAGAAAGAACACTACCACTGCAACATTAATGGATGCTTGAAGCTGTACAAAAGCTGCAGTAACCTGTCTTCAGTTACTTTGT AATTTATTGTGGCATGAGATAAGATGGGGAAAATTTTGTTTTAAGTGGTATGGATATATTTAGCATATTGAACCACACAAGTGCTTAATT CATTGTTATGTAATCTTTGTACATATAGGCAGTATTTTTTCTGTGAAACTTCATATTGCTGAAGACATACACTAAGAATTTATGTAGATA ATGTACTTTTATGAGATGTACAAGTAAGTGTCTTATCTGTACAGATGTAAATGTTGATGAAAATGCAATTGGGGTTAATATTTTAAGAAT TCTTTAGTATATTCTTGGGTGTGGCTATATTACAAAATGGGATGCTGGCAATGAAACAATACATTTAACACTATTGTATTTTTATTATAT GTAATTTAGTAATATGAATATAAATCTTGTAACTTTTAAAATTGTAATGGAGGCTGTAATCATTTTATAATCTTTTTAATTTTAATGCAA GTACACTGGTGTTTATATTTGCACAAAGTATTGATATGTGATGTATTAAGTCACAAAAGTAAGCTGTGACATTGTCTATAAGCATTTGGC TCCACAAATGTATTTGGATTGTTTTCTATGTGAAGCAAACCAATTATAATTAACCACATGTTGTAGTAACTGGTCTTTTTATATTTAAGC AGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAACAATACCTTTGAACATTTTTGAATCACAGAATAGCGGTACCATGATAGAATACTG CAATTGTGGTCAGAATTACAGTATGCACAAAGAATTAATTAGCATTATTAAAGAGTCCTCACTAAACATTTCATATGATCACACTGAAGA ACTGTAACATTCCATAGAGTGAAGTGGTTCAAATTTCTCTTGGAATTTTTACTTTTGTTGGCCTTATTTTATGATCCTTTTCATATTTCT TTTGACTTAGAGTATTAATACATGGCCAAAATAATTTAGTTACTACCTCATACAAACAATATAATGGTTACTACACATCACAGGAACTTA GTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCCAATGGAATATGTATATACCAGGTTTTAGCAAAATGCACACTTTTGGCTCTTTTTG GTATATGTTCTTTATATTTTAATGTGAGTATATACACTAAGAACAAACTAAATTGTGATTTATGATCTTCATTTATTTTAATGATAATGG >85262_85262_3_SOS1-MAP4K3_SOS1_chr2_39283842_ENST00000395038_MAP4K3_chr2_39605264_ENST00000263881_length(amino acids)=1032AA_BP=170 MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADA QSAIEKRKRRNPLSLPVEKIHPLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKARNVNTGELA AIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGK MHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRA LFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVP HRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEE LHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALG NGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEG IYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWC QKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNST SSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEI -------------------------------------------------------------- >85262_85262_4_SOS1-MAP4K3_SOS1_chr2_39283842_ENST00000402219_MAP4K3_chr2_39605264_ENST00000263881_length(transcript)=4492nt_BP=551nt CCGCCGCCCCTCTCCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGC CCAAGTGGCGGGGACTACTGGTGCCTGCGCTGAAAAAGGTCCAGGGGCAAGTTCATCCTACTCTCGAGTCTAATGATGATGCTCTTCAGT ATGTTGAAGAATTAATTTTGCAATTATTAAATATGCTATGCCAAGCTCAGCCCCGAAGTGCTTCAGATGTAGAGGAACGTGTTCAAAAAA GTTTCCCTCATCCAATTGATAAATGGGCAATAGCTGATGCCCAATCAGCTATTGAAAAGAGGAAGCGAAGAAACCCTTTATCTCTCCCAG TAGAAAAAATTCATCCTTTATTAAAGGAGGTCCTAGGTTATAAAATTGACCACCAGGTTTCTGTTTACATAGTAGCAGTCTTAGAATACA TTTCTGCAGACATTTTAAAGCTGGTTGGGAATTATGTAAGAAATATACGGCATTATGAAATTACAAAACAAGATATTAAAGTGGCAATGT GTGCTGACAAGGCACGGAATGTTAACACTGGTGAATTAGCAGCAATTAAAGTAATAAAATTGGAACCAGGAGAAGACTTTGCAGTTGTGC AGCAAGAAATTATTATGATGAAAGACTGTAAACACCCAAATATTGTTGCTTATTTTGGAAGCTATCTCAGGCGAGATAAGCTTTGGATTT GCATGGAGTTTTGTGGAGGTGGTTCTTTACAGGATATTTATCACGTAACTGGACCTCTGTCAGAACTGCAAATTGCATATGTTAGCAGAG AAACACTGCAGGGATTATATTATCTTCACAGTAAAGGAAAAATGCACAGAGATATAAAGGGAGCTAACATTCTATTAACGGATAATGGTC ATGTGAAATTGGCTGATTTTGGAGTATCTGCACAGATAACAGCTACAATTGCCAAACGGAAGTCTTTCATTGGCACACCATATTGGATGG CTCCAGAAGTTGCAGCTGTTGAGAGGAAGGGGGGTTACAATCAACTCTGTGATCTCTGGGCAGTGGGAATCACTGCCATAGAACTTGCAG AGCTTCAGCCTCCTATGTTTGACTTACACCCAATGAGAGCATTATTTCTAATGACAAAAAGCAATTTTCAGCCTCCTAAACTAAAGGATA AAATGAAATGGTCAAATAGTTTTCATCACTTTGTGAAAATGGCACTTACCAAAAATCCGAAAAAAAGACCTACTGCTGAAAAATTATTAC AGCATCCTTTTGTAACACAACATTTGACACGGTCTTTGGCAATCGAGCTGTTGGATAAAGTAAATAATCCAGATCATTCCACTTACCATG ATTTCGATGATGATGATCCTGAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAGAAGAAAAAACACGCT CAGAGATAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTCCCGACAGTGATGGTTTTT TGGACAGTTCAGAAGAAATATACTACACTGCAAGATCTAATCTGGATCTGCAACTGGAATATGGACAAGGACACCAAGGTGGTTACTTTT TAGGTGCAAACAAGAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATCAGCGAGGACACGTCGCACATTTAGAAGATGATGAAGGAGATG ATGATGAATCTAAACACTCAACTCTGAAAGCAAAAATTCCACCTCCTTTGCCACCAAAGCCTAAGTCTATCTTCATACCACAGGAAATGC ATTCTACTGAGGATGAAAATCAAGGAACAATCAAGAGATGTCCCATGTCAGGGAGCCCAGCAAAGCCATCCCAAGTTCCACCTAGACCAC CACCTCCCAGATTACCCCCACACAAACCTGTTGCCTTAGGAAATGGAATGAGCTCCTTCCAGTTAAATGGTGAACGAGATGGCTCATTAT GTCAACAACAGAATGAACATAGAGGCACAAACCTTTCAAGAAAAGAAAAGAAAGATGTACCAAAGCCTATTAGTAATGGTCTTCCTCCAA CACCTAAAGTGCATATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGTGTCCCTTGAAAATTCACTGTGCATCATCATGGATAAACCCAG ATACAAGAGATCAGTACTTGATATTTGGTGCCGAAGAAGGGATTTATACCCTCAATCTTAATGAACTTCATGAAACATCAATGGAACAGC TATTCCCTCGAAGGTGTACATGGTTGTATGTAATGAACAATTGCTTGCTATCAATATCTGGTAAAGCTTCTCAGCTTTATTCCCATAATT TACCAGGGCTTTTTGATTATGCAAGACAAATGCAAAAGTTACCTGTTGCTATTCCAGCACACAAACTCCCTGACAGAATACTGCCAAGGA AATTTTCTGTATCAGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGTGTTGTGTTGTAAGAAATCCTTACACGGGCCATAAATACCTAT GTGGAGCACTTCAGACTAGCATTGTTCTATTAGAATGGGTTGAACCAATGCAGAAATTTATGTTAATTAAGCACATAGATTTTCCTATAC CATGTCCACTTAGAATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGTACCCTTTAGTTTGTGTTGGTGTCAGTAGAGGTAGAGACTTCA ACCAAGTGGTTCGATTTGAGACGGTCAATCCAAATTCTACCTCTTCATGGTTTACAGAATCAGATACCCCACAGACAAATGTTACTCATG TAACCCAACTGGAGAGAGATACCATCCTTGTATGCTTGGACTGTTGTATAAAAATAGTAAATCTCCAAGGAAGATTAAAATCTAGCAGGA AATTGTCATCAGAACTCACCTTTGATTTCCAGATTGAATCAATAGTGTGCCTACAAGACAGTGTGCTAGCTTTCTGGAAACATGGAATGC AAGGTAGAAGTTTTAGATCTAATGAGGTAACACAAGAAATTTCAGATAGCACAAGAATTTTCAGGCTGCTTGGATCTGACAGGGTCGTGG TTTTGGAAAGTAGGCCAACTGATAACCCCACAGCAAATAGCAATTTGTACATCCTGGCGGGTCATGAAAACAGTTACTGAGAATTGTTGT GCTTTGACAGTTAACTCTAGAAAGAAAGAACACTACCACTGCAACATTAATGGATGCTTGAAGCTGTACAAAAGCTGCAGTAACCTGTCT TCAGTTACTTTGTAATTTATTGTGGCATGAGATAAGATGGGGAAAATTTTGTTTTAAGTGGTATGGATATATTTAGCATATTGAACCACA CAAGTGCTTAATTCATTGTTATGTAATCTTTGTACATATAGGCAGTATTTTTTCTGTGAAACTTCATATTGCTGAAGACATACACTAAGA ATTTATGTAGATAATGTACTTTTATGAGATGTACAAGTAAGTGTCTTATCTGTACAGATGTAAATGTTGATGAAAATGCAATTGGGGTTA ATATTTTAAGAATTCTTTAGTATATTCTTGGGTGTGGCTATATTACAAAATGGGATGCTGGCAATGAAACAATACATTTAACACTATTGT ATTTTTATTATATGTAATTTAGTAATATGAATATAAATCTTGTAACTTTTAAAATTGTAATGGAGGCTGTAATCATTTTATAATCTTTTT AATTTTAATGCAAGTACACTGGTGTTTATATTTGCACAAAGTATTGATATGTGATGTATTAAGTCACAAAAGTAAGCTGTGACATTGTCT ATAAGCATTTGGCTCCACAAATGTATTTGGATTGTTTTCTATGTGAAGCAAACCAATTATAATTAACCACATGTTGTAGTAACTGGTCTT TTTATATTTAAGCAGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAACAATACCTTTGAACATTTTTGAATCACAGAATAGCGGTACCA TGATAGAATACTGCAATTGTGGTCAGAATTACAGTATGCACAAAGAATTAATTAGCATTATTAAAGAGTCCTCACTAAACATTTCATATG ATCACACTGAAGAACTGTAACATTCCATAGAGTGAAGTGGTTCAAATTTCTCTTGGAATTTTTACTTTTGTTGGCCTTATTTTATGATCC TTTTCATATTTCTTTTGACTTAGAGTATTAATACATGGCCAAAATAATTTAGTTACTACCTCATACAAACAATATAATGGTTACTACACA TCACAGGAACTTAGTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCCAATGGAATATGTATATACCAGGTTTTAGCAAAATGCACACTT TTGGCTCTTTTTGGTATATGTTCTTTATATTTTAATGTGAGTATATACACTAAGAACAAACTAAATTGTGATTTATGATCTTCATTTATT >85262_85262_4_SOS1-MAP4K3_SOS1_chr2_39283842_ENST00000402219_MAP4K3_chr2_39605264_ENST00000263881_length(amino acids)=1032AA_BP=170 MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADA QSAIEKRKRRNPLSLPVEKIHPLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKARNVNTGELA AIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGK MHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRA LFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVP HRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEE LHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALG NGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEG IYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWC QKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNST SSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEI -------------------------------------------------------------- >85262_85262_5_SOS1-MAP4K3_SOS1_chr2_39283843_ENST00000395038_MAP4K3_chr2_39605264_ENST00000263881_length(transcript)=4479nt_BP=538nt CCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGCCCAAGTGGCGGGG ACTACTGGTGCCTGCGCTGAAAAAGGTCCAGGGGCAAGTTCATCCTACTCTCGAGTCTAATGATGATGCTCTTCAGTATGTTGAAGAATT AATTTTGCAATTATTAAATATGCTATGCCAAGCTCAGCCCCGAAGTGCTTCAGATGTAGAGGAACGTGTTCAAAAAAGTTTCCCTCATCC AATTGATAAATGGGCAATAGCTGATGCCCAATCAGCTATTGAAAAGAGGAAGCGAAGAAACCCTTTATCTCTCCCAGTAGAAAAAATTCA TCCTTTATTAAAGGAGGTCCTAGGTTATAAAATTGACCACCAGGTTTCTGTTTACATAGTAGCAGTCTTAGAATACATTTCTGCAGACAT TTTAAAGCTGGTTGGGAATTATGTAAGAAATATACGGCATTATGAAATTACAAAACAAGATATTAAAGTGGCAATGTGTGCTGACAAGGC ACGGAATGTTAACACTGGTGAATTAGCAGCAATTAAAGTAATAAAATTGGAACCAGGAGAAGACTTTGCAGTTGTGCAGCAAGAAATTAT TATGATGAAAGACTGTAAACACCCAAATATTGTTGCTTATTTTGGAAGCTATCTCAGGCGAGATAAGCTTTGGATTTGCATGGAGTTTTG TGGAGGTGGTTCTTTACAGGATATTTATCACGTAACTGGACCTCTGTCAGAACTGCAAATTGCATATGTTAGCAGAGAAACACTGCAGGG ATTATATTATCTTCACAGTAAAGGAAAAATGCACAGAGATATAAAGGGAGCTAACATTCTATTAACGGATAATGGTCATGTGAAATTGGC TGATTTTGGAGTATCTGCACAGATAACAGCTACAATTGCCAAACGGAAGTCTTTCATTGGCACACCATATTGGATGGCTCCAGAAGTTGC AGCTGTTGAGAGGAAGGGGGGTTACAATCAACTCTGTGATCTCTGGGCAGTGGGAATCACTGCCATAGAACTTGCAGAGCTTCAGCCTCC TATGTTTGACTTACACCCAATGAGAGCATTATTTCTAATGACAAAAAGCAATTTTCAGCCTCCTAAACTAAAGGATAAAATGAAATGGTC AAATAGTTTTCATCACTTTGTGAAAATGGCACTTACCAAAAATCCGAAAAAAAGACCTACTGCTGAAAAATTATTACAGCATCCTTTTGT AACACAACATTTGACACGGTCTTTGGCAATCGAGCTGTTGGATAAAGTAAATAATCCAGATCATTCCACTTACCATGATTTCGATGATGA TGATCCTGAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAGAAGAAAAAACACGCTCAGAGATAACCTT TGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTCCCGACAGTGATGGTTTTTTGGACAGTTCAGA AGAAATATACTACACTGCAAGATCTAATCTGGATCTGCAACTGGAATATGGACAAGGACACCAAGGTGGTTACTTTTTAGGTGCAAACAA GAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATCAGCGAGGACACGTCGCACATTTAGAAGATGATGAAGGAGATGATGATGAATCTAA ACACTCAACTCTGAAAGCAAAAATTCCACCTCCTTTGCCACCAAAGCCTAAGTCTATCTTCATACCACAGGAAATGCATTCTACTGAGGA TGAAAATCAAGGAACAATCAAGAGATGTCCCATGTCAGGGAGCCCAGCAAAGCCATCCCAAGTTCCACCTAGACCACCACCTCCCAGATT ACCCCCACACAAACCTGTTGCCTTAGGAAATGGAATGAGCTCCTTCCAGTTAAATGGTGAACGAGATGGCTCATTATGTCAACAACAGAA TGAACATAGAGGCACAAACCTTTCAAGAAAAGAAAAGAAAGATGTACCAAAGCCTATTAGTAATGGTCTTCCTCCAACACCTAAAGTGCA TATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGTGTCCCTTGAAAATTCACTGTGCATCATCATGGATAAACCCAGATACAAGAGATCA GTACTTGATATTTGGTGCCGAAGAAGGGATTTATACCCTCAATCTTAATGAACTTCATGAAACATCAATGGAACAGCTATTCCCTCGAAG GTGTACATGGTTGTATGTAATGAACAATTGCTTGCTATCAATATCTGGTAAAGCTTCTCAGCTTTATTCCCATAATTTACCAGGGCTTTT TGATTATGCAAGACAAATGCAAAAGTTACCTGTTGCTATTCCAGCACACAAACTCCCTGACAGAATACTGCCAAGGAAATTTTCTGTATC AGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGTGTTGTGTTGTAAGAAATCCTTACACGGGCCATAAATACCTATGTGGAGCACTTCA GACTAGCATTGTTCTATTAGAATGGGTTGAACCAATGCAGAAATTTATGTTAATTAAGCACATAGATTTTCCTATACCATGTCCACTTAG AATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGTACCCTTTAGTTTGTGTTGGTGTCAGTAGAGGTAGAGACTTCAACCAAGTGGTTCG ATTTGAGACGGTCAATCCAAATTCTACCTCTTCATGGTTTACAGAATCAGATACCCCACAGACAAATGTTACTCATGTAACCCAACTGGA GAGAGATACCATCCTTGTATGCTTGGACTGTTGTATAAAAATAGTAAATCTCCAAGGAAGATTAAAATCTAGCAGGAAATTGTCATCAGA ACTCACCTTTGATTTCCAGATTGAATCAATAGTGTGCCTACAAGACAGTGTGCTAGCTTTCTGGAAACATGGAATGCAAGGTAGAAGTTT TAGATCTAATGAGGTAACACAAGAAATTTCAGATAGCACAAGAATTTTCAGGCTGCTTGGATCTGACAGGGTCGTGGTTTTGGAAAGTAG GCCAACTGATAACCCCACAGCAAATAGCAATTTGTACATCCTGGCGGGTCATGAAAACAGTTACTGAGAATTGTTGTGCTTTGACAGTTA ACTCTAGAAAGAAAGAACACTACCACTGCAACATTAATGGATGCTTGAAGCTGTACAAAAGCTGCAGTAACCTGTCTTCAGTTACTTTGT AATTTATTGTGGCATGAGATAAGATGGGGAAAATTTTGTTTTAAGTGGTATGGATATATTTAGCATATTGAACCACACAAGTGCTTAATT CATTGTTATGTAATCTTTGTACATATAGGCAGTATTTTTTCTGTGAAACTTCATATTGCTGAAGACATACACTAAGAATTTATGTAGATA ATGTACTTTTATGAGATGTACAAGTAAGTGTCTTATCTGTACAGATGTAAATGTTGATGAAAATGCAATTGGGGTTAATATTTTAAGAAT TCTTTAGTATATTCTTGGGTGTGGCTATATTACAAAATGGGATGCTGGCAATGAAACAATACATTTAACACTATTGTATTTTTATTATAT GTAATTTAGTAATATGAATATAAATCTTGTAACTTTTAAAATTGTAATGGAGGCTGTAATCATTTTATAATCTTTTTAATTTTAATGCAA GTACACTGGTGTTTATATTTGCACAAAGTATTGATATGTGATGTATTAAGTCACAAAAGTAAGCTGTGACATTGTCTATAAGCATTTGGC TCCACAAATGTATTTGGATTGTTTTCTATGTGAAGCAAACCAATTATAATTAACCACATGTTGTAGTAACTGGTCTTTTTATATTTAAGC AGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAACAATACCTTTGAACATTTTTGAATCACAGAATAGCGGTACCATGATAGAATACTG CAATTGTGGTCAGAATTACAGTATGCACAAAGAATTAATTAGCATTATTAAAGAGTCCTCACTAAACATTTCATATGATCACACTGAAGA ACTGTAACATTCCATAGAGTGAAGTGGTTCAAATTTCTCTTGGAATTTTTACTTTTGTTGGCCTTATTTTATGATCCTTTTCATATTTCT TTTGACTTAGAGTATTAATACATGGCCAAAATAATTTAGTTACTACCTCATACAAACAATATAATGGTTACTACACATCACAGGAACTTA GTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCCAATGGAATATGTATATACCAGGTTTTAGCAAAATGCACACTTTTGGCTCTTTTTG GTATATGTTCTTTATATTTTAATGTGAGTATATACACTAAGAACAAACTAAATTGTGATTTATGATCTTCATTTATTTTAATGATAATGG >85262_85262_5_SOS1-MAP4K3_SOS1_chr2_39283843_ENST00000395038_MAP4K3_chr2_39605264_ENST00000263881_length(amino acids)=1032AA_BP=170 MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADA QSAIEKRKRRNPLSLPVEKIHPLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKARNVNTGELA AIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGK MHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRA LFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVP HRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEE LHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALG NGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEG IYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWC QKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNST SSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEI -------------------------------------------------------------- >85262_85262_6_SOS1-MAP4K3_SOS1_chr2_39283843_ENST00000402219_MAP4K3_chr2_39605264_ENST00000263881_length(transcript)=4492nt_BP=551nt CCGCCGCCCCTCTCCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGC CCAAGTGGCGGGGACTACTGGTGCCTGCGCTGAAAAAGGTCCAGGGGCAAGTTCATCCTACTCTCGAGTCTAATGATGATGCTCTTCAGT ATGTTGAAGAATTAATTTTGCAATTATTAAATATGCTATGCCAAGCTCAGCCCCGAAGTGCTTCAGATGTAGAGGAACGTGTTCAAAAAA GTTTCCCTCATCCAATTGATAAATGGGCAATAGCTGATGCCCAATCAGCTATTGAAAAGAGGAAGCGAAGAAACCCTTTATCTCTCCCAG TAGAAAAAATTCATCCTTTATTAAAGGAGGTCCTAGGTTATAAAATTGACCACCAGGTTTCTGTTTACATAGTAGCAGTCTTAGAATACA TTTCTGCAGACATTTTAAAGCTGGTTGGGAATTATGTAAGAAATATACGGCATTATGAAATTACAAAACAAGATATTAAAGTGGCAATGT GTGCTGACAAGGCACGGAATGTTAACACTGGTGAATTAGCAGCAATTAAAGTAATAAAATTGGAACCAGGAGAAGACTTTGCAGTTGTGC AGCAAGAAATTATTATGATGAAAGACTGTAAACACCCAAATATTGTTGCTTATTTTGGAAGCTATCTCAGGCGAGATAAGCTTTGGATTT GCATGGAGTTTTGTGGAGGTGGTTCTTTACAGGATATTTATCACGTAACTGGACCTCTGTCAGAACTGCAAATTGCATATGTTAGCAGAG AAACACTGCAGGGATTATATTATCTTCACAGTAAAGGAAAAATGCACAGAGATATAAAGGGAGCTAACATTCTATTAACGGATAATGGTC ATGTGAAATTGGCTGATTTTGGAGTATCTGCACAGATAACAGCTACAATTGCCAAACGGAAGTCTTTCATTGGCACACCATATTGGATGG CTCCAGAAGTTGCAGCTGTTGAGAGGAAGGGGGGTTACAATCAACTCTGTGATCTCTGGGCAGTGGGAATCACTGCCATAGAACTTGCAG AGCTTCAGCCTCCTATGTTTGACTTACACCCAATGAGAGCATTATTTCTAATGACAAAAAGCAATTTTCAGCCTCCTAAACTAAAGGATA AAATGAAATGGTCAAATAGTTTTCATCACTTTGTGAAAATGGCACTTACCAAAAATCCGAAAAAAAGACCTACTGCTGAAAAATTATTAC AGCATCCTTTTGTAACACAACATTTGACACGGTCTTTGGCAATCGAGCTGTTGGATAAAGTAAATAATCCAGATCATTCCACTTACCATG ATTTCGATGATGATGATCCTGAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAGAAGAAAAAACACGCT CAGAGATAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTCCCGACAGTGATGGTTTTT TGGACAGTTCAGAAGAAATATACTACACTGCAAGATCTAATCTGGATCTGCAACTGGAATATGGACAAGGACACCAAGGTGGTTACTTTT TAGGTGCAAACAAGAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATCAGCGAGGACACGTCGCACATTTAGAAGATGATGAAGGAGATG ATGATGAATCTAAACACTCAACTCTGAAAGCAAAAATTCCACCTCCTTTGCCACCAAAGCCTAAGTCTATCTTCATACCACAGGAAATGC ATTCTACTGAGGATGAAAATCAAGGAACAATCAAGAGATGTCCCATGTCAGGGAGCCCAGCAAAGCCATCCCAAGTTCCACCTAGACCAC CACCTCCCAGATTACCCCCACACAAACCTGTTGCCTTAGGAAATGGAATGAGCTCCTTCCAGTTAAATGGTGAACGAGATGGCTCATTAT GTCAACAACAGAATGAACATAGAGGCACAAACCTTTCAAGAAAAGAAAAGAAAGATGTACCAAAGCCTATTAGTAATGGTCTTCCTCCAA CACCTAAAGTGCATATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGTGTCCCTTGAAAATTCACTGTGCATCATCATGGATAAACCCAG ATACAAGAGATCAGTACTTGATATTTGGTGCCGAAGAAGGGATTTATACCCTCAATCTTAATGAACTTCATGAAACATCAATGGAACAGC TATTCCCTCGAAGGTGTACATGGTTGTATGTAATGAACAATTGCTTGCTATCAATATCTGGTAAAGCTTCTCAGCTTTATTCCCATAATT TACCAGGGCTTTTTGATTATGCAAGACAAATGCAAAAGTTACCTGTTGCTATTCCAGCACACAAACTCCCTGACAGAATACTGCCAAGGA AATTTTCTGTATCAGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGTGTTGTGTTGTAAGAAATCCTTACACGGGCCATAAATACCTAT GTGGAGCACTTCAGACTAGCATTGTTCTATTAGAATGGGTTGAACCAATGCAGAAATTTATGTTAATTAAGCACATAGATTTTCCTATAC CATGTCCACTTAGAATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGTACCCTTTAGTTTGTGTTGGTGTCAGTAGAGGTAGAGACTTCA ACCAAGTGGTTCGATTTGAGACGGTCAATCCAAATTCTACCTCTTCATGGTTTACAGAATCAGATACCCCACAGACAAATGTTACTCATG TAACCCAACTGGAGAGAGATACCATCCTTGTATGCTTGGACTGTTGTATAAAAATAGTAAATCTCCAAGGAAGATTAAAATCTAGCAGGA AATTGTCATCAGAACTCACCTTTGATTTCCAGATTGAATCAATAGTGTGCCTACAAGACAGTGTGCTAGCTTTCTGGAAACATGGAATGC AAGGTAGAAGTTTTAGATCTAATGAGGTAACACAAGAAATTTCAGATAGCACAAGAATTTTCAGGCTGCTTGGATCTGACAGGGTCGTGG TTTTGGAAAGTAGGCCAACTGATAACCCCACAGCAAATAGCAATTTGTACATCCTGGCGGGTCATGAAAACAGTTACTGAGAATTGTTGT GCTTTGACAGTTAACTCTAGAAAGAAAGAACACTACCACTGCAACATTAATGGATGCTTGAAGCTGTACAAAAGCTGCAGTAACCTGTCT TCAGTTACTTTGTAATTTATTGTGGCATGAGATAAGATGGGGAAAATTTTGTTTTAAGTGGTATGGATATATTTAGCATATTGAACCACA CAAGTGCTTAATTCATTGTTATGTAATCTTTGTACATATAGGCAGTATTTTTTCTGTGAAACTTCATATTGCTGAAGACATACACTAAGA ATTTATGTAGATAATGTACTTTTATGAGATGTACAAGTAAGTGTCTTATCTGTACAGATGTAAATGTTGATGAAAATGCAATTGGGGTTA ATATTTTAAGAATTCTTTAGTATATTCTTGGGTGTGGCTATATTACAAAATGGGATGCTGGCAATGAAACAATACATTTAACACTATTGT ATTTTTATTATATGTAATTTAGTAATATGAATATAAATCTTGTAACTTTTAAAATTGTAATGGAGGCTGTAATCATTTTATAATCTTTTT AATTTTAATGCAAGTACACTGGTGTTTATATTTGCACAAAGTATTGATATGTGATGTATTAAGTCACAAAAGTAAGCTGTGACATTGTCT ATAAGCATTTGGCTCCACAAATGTATTTGGATTGTTTTCTATGTGAAGCAAACCAATTATAATTAACCACATGTTGTAGTAACTGGTCTT TTTATATTTAAGCAGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAACAATACCTTTGAACATTTTTGAATCACAGAATAGCGGTACCA TGATAGAATACTGCAATTGTGGTCAGAATTACAGTATGCACAAAGAATTAATTAGCATTATTAAAGAGTCCTCACTAAACATTTCATATG ATCACACTGAAGAACTGTAACATTCCATAGAGTGAAGTGGTTCAAATTTCTCTTGGAATTTTTACTTTTGTTGGCCTTATTTTATGATCC TTTTCATATTTCTTTTGACTTAGAGTATTAATACATGGCCAAAATAATTTAGTTACTACCTCATACAAACAATATAATGGTTACTACACA TCACAGGAACTTAGTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCCAATGGAATATGTATATACCAGGTTTTAGCAAAATGCACACTT TTGGCTCTTTTTGGTATATGTTCTTTATATTTTAATGTGAGTATATACACTAAGAACAAACTAAATTGTGATTTATGATCTTCATTTATT >85262_85262_6_SOS1-MAP4K3_SOS1_chr2_39283843_ENST00000402219_MAP4K3_chr2_39605264_ENST00000263881_length(amino acids)=1032AA_BP=170 MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADA QSAIEKRKRRNPLSLPVEKIHPLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKARNVNTGELA AIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGK MHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRA LFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVP HRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEE LHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALG NGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEG IYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWC QKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNST SSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEI -------------------------------------------------------------- >85262_85262_7_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000395038_MAP4K3_chr2_39542529_ENST00000263881_length(transcript)=3234nt_BP=115nt CCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGCCCAAGTGGCGGGG ACTACTGGTGCCTGCGCTGAAAAAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAGAAGAAAAAACACG CTCAGAGATAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTCCCGACAGTGATGGTTT TTTGGACAGTTCAGAAGAAATATACTACACTGCAAGATCTAATCTGGATCTGCAACTGGAATATGGACAAGGACACCAAGGTGGTTACTT TTTAGGTGCAAACAAGAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATCAGCGAGGACACGTCGCACATTTAGAAGATGATGAAGGAGA TGATGATGAATCTAAACACTCAACTCTGAAAGCAAAAATTCCACCTCCTTTGCCACCAAAGCCTAAGTCTATCTTCATACCACAGGAAAT GCATTCTACTGAGGATGAAAATCAAGGAACAATCAAGAGATGTCCCATGTCAGGGAGCCCAGCAAAGCCATCCCAAGTTCCACCTAGACC ACCACCTCCCAGATTACCCCCACACAAACCTGTTGCCTTAGGAAATGGAATGAGCTCCTTCCAGTTAAATGGTGAACGAGATGGCTCATT ATGTCAACAACAGAATGAACATAGAGGCACAAACCTTTCAAGAAAAGAAAAGAAAGATGTACCAAAGCCTATTAGTAATGGTCTTCCTCC AACACCTAAAGTGCATATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGTGTCCCTTGAAAATTCACTGTGCATCATCATGGATAAACCC AGATACAAGAGATCAGTACTTGATATTTGGTGCCGAAGAAGGGATTTATACCCTCAATCTTAATGAACTTCATGAAACATCAATGGAACA GCTATTCCCTCGAAGGTGTACATGGTTGTATGTAATGAACAATTGCTTGCTATCAATATCTGGTAAAGCTTCTCAGCTTTATTCCCATAA TTTACCAGGGCTTTTTGATTATGCAAGACAAATGCAAAAGTTACCTGTTGCTATTCCAGCACACAAACTCCCTGACAGAATACTGCCAAG GAAATTTTCTGTATCAGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGTGTTGTGTTGTAAGAAATCCTTACACGGGCCATAAATACCT ATGTGGAGCACTTCAGACTAGCATTGTTCTATTAGAATGGGTTGAACCAATGCAGAAATTTATGTTAATTAAGCACATAGATTTTCCTAT ACCATGTCCACTTAGAATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGTACCCTTTAGTTTGTGTTGGTGTCAGTAGAGGTAGAGACTT CAACCAAGTGGTTCGATTTGAGACGGTCAATCCAAATTCTACCTCTTCATGGTTTACAGAATCAGATACCCCACAGACAAATGTTACTCA TGTAACCCAACTGGAGAGAGATACCATCCTTGTATGCTTGGACTGTTGTATAAAAATAGTAAATCTCCAAGGAAGATTAAAATCTAGCAG GAAATTGTCATCAGAACTCACCTTTGATTTCCAGATTGAATCAATAGTGTGCCTACAAGACAGTGTGCTAGCTTTCTGGAAACATGGAAT GCAAGGTAGAAGTTTTAGATCTAATGAGGTAACACAAGAAATTTCAGATAGCACAAGAATTTTCAGGCTGCTTGGATCTGACAGGGTCGT GGTTTTGGAAAGTAGGCCAACTGATAACCCCACAGCAAATAGCAATTTGTACATCCTGGCGGGTCATGAAAACAGTTACTGAGAATTGTT GTGCTTTGACAGTTAACTCTAGAAAGAAAGAACACTACCACTGCAACATTAATGGATGCTTGAAGCTGTACAAAAGCTGCAGTAACCTGT CTTCAGTTACTTTGTAATTTATTGTGGCATGAGATAAGATGGGGAAAATTTTGTTTTAAGTGGTATGGATATATTTAGCATATTGAACCA CACAAGTGCTTAATTCATTGTTATGTAATCTTTGTACATATAGGCAGTATTTTTTCTGTGAAACTTCATATTGCTGAAGACATACACTAA GAATTTATGTAGATAATGTACTTTTATGAGATGTACAAGTAAGTGTCTTATCTGTACAGATGTAAATGTTGATGAAAATGCAATTGGGGT TAATATTTTAAGAATTCTTTAGTATATTCTTGGGTGTGGCTATATTACAAAATGGGATGCTGGCAATGAAACAATACATTTAACACTATT GTATTTTTATTATATGTAATTTAGTAATATGAATATAAATCTTGTAACTTTTAAAATTGTAATGGAGGCTGTAATCATTTTATAATCTTT TTAATTTTAATGCAAGTACACTGGTGTTTATATTTGCACAAAGTATTGATATGTGATGTATTAAGTCACAAAAGTAAGCTGTGACATTGT CTATAAGCATTTGGCTCCACAAATGTATTTGGATTGTTTTCTATGTGAAGCAAACCAATTATAATTAACCACATGTTGTAGTAACTGGTC TTTTTATATTTAAGCAGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAACAATACCTTTGAACATTTTTGAATCACAGAATAGCGGTAC CATGATAGAATACTGCAATTGTGGTCAGAATTACAGTATGCACAAAGAATTAATTAGCATTATTAAAGAGTCCTCACTAAACATTTCATA TGATCACACTGAAGAACTGTAACATTCCATAGAGTGAAGTGGTTCAAATTTCTCTTGGAATTTTTACTTTTGTTGGCCTTATTTTATGAT CCTTTTCATATTTCTTTTGACTTAGAGTATTAATACATGGCCAAAATAATTTAGTTACTACCTCATACAAACAATATAATGGTTACTACA CATCACAGGAACTTAGTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCCAATGGAATATGTATATACCAGGTTTTAGCAAAATGCACAC TTTTGGCTCTTTTTGGTATATGTTCTTTATATTTTAATGTGAGTATATACACTAAGAACAAACTAAATTGTGATTTATGATCTTCATTTA >85262_85262_7_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000395038_MAP4K3_chr2_39542529_ENST00000263881_length(amino acids)=617AA_BP=29 MQAQQLPYEFFSEENAPKWRGLLVPALKKPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYY TARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQG TIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGAC FSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYAR QMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEM LVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFD -------------------------------------------------------------- >85262_85262_8_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000395038_MAP4K3_chr2_39542529_ENST00000341681_length(transcript)=3154nt_BP=115nt CCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGCCCAAGTGGCGGGG ACTACTGGTGCCTGCGCTGAAAAAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAGAAGAAAAAACACG CTCAGAGATAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTGATCTGCAACTGGAATA TGGACAAGGACACCAAGGTGGTTACTTTTTAGGTGCAAACAAGAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATCAGCGAGGACACGT CGCACATTTAGAAGATGATGAAGGAGATGATGATGAATCTAAACACTCAACTCTGAAAGCAAAAATTCCACCTCCTTTGCCACCAAAGCC TAAGTCTATCTTCATACCACAGGAAATGCATTCTACTGAGGATGAAAATCAAGGAACAATCAAGAGATGTCCCATGTCAGGGAGCCCAGC AAAGCCATCCCAAGTTCCACCTAGACCACCACCTCCCAGATTACCCCCACACAAACCTGTTGCCTTAGGAAATGGAATGAGCTCCTTCCA GTTAAATGGTGAACGAGATGGCTCATTATGTCAACAACAGAATGAACATAGAGGCACAAACCTTTCAAGAAAAGAAAAGAAAGATGTACC AAAGCCTATTAGTAATGGTCTTCCTCCAACACCTAAAGTGCATATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGTGTCCCTTGAAAAT TCACTGTGCATCATCATGGATAAACCCAGATACAAGAGATCAGTACTTGATATTTGGTGCCGAAGAAGGGATTTATACCCTCAATCTTAA TGAACTTCATGAAACATCAATGGAACAGCTATTCCCTCGAAGGTGTACATGGTTGTATGTAATGAACAATTGCTTGCTATCAATATCTGG TAAAGCTTCTCAGCTTTATTCCCATAATTTACCAGGGCTTTTTGATTATGCAAGACAAATGCAAAAGTTACCTGTTGCTATTCCAGCACA CAAACTCCCTGACAGAATACTGCCAAGGAAATTTTCTGTATCAGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGTGTTGTGTTGTAAG AAATCCTTACACGGGCCATAAATACCTATGTGGAGCACTTCAGACTAGCATTGTTCTATTAGAATGGGTTGAACCAATGCAGAAATTTAT GTTAATTAAGCACATAGATTTTCCTATACCATGTCCACTTAGAATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGTACCCTTTAGTTTG TGTTGGTGTCAGTAGAGGTAGAGACTTCAACCAAGTGGTTCGATTTGAGACGGTCAATCCAAATTCTACCTCTTCATGGTTTACAGAATC AGATACCCCACAGACAAATGTTACTCATGTAACCCAACTGGAGAGAGATACCATCCTTGTATGCTTGGACTGTTGTATAAAAATAGTAAA TCTCCAAGGAAGATTAAAATCTAGCAGGAAATTGTCATCAGAACTCACCTTTGATTTCCAGATTGAATCAATAGTGTGCCTACAAGACAG TGTGCTAGCTTTCTGGAAACATGGAATGCAAGGTAGAAGTTTTAGATCTAATGAGGTAACACAAGAAATTTCAGATAGCACAAGAATTTT CAGGCTGCTTGGATCTGACAGGGTCGTGGTTTTGGAAAGTAGGCCAACTGATAACCCCACAGCAAATAGCAATTTGTACATCCTGGCGGG TCATGAAAACAGTTACTGAGAATTGTTGTGCTTTGACAGTTAACTCTAGAAAGAAAGAACACTACCACTGCAACATTAATGGATGCTTGA AGCTGTACAAAAGCTGCAGTAACCTGTCTTCAGTTACTTTGTAATTTATTGTGGCATGAGATAAGATGGGGAAAATTTTGTTTTAAGTGG TATGGATATATTTAGCATATTGAACCACACAAGTGCTTAATTCATTGTTATGTAATCTTTGTACATATAGGCAGTATTTTTTCTGTGAAA CTTCATATTGCTGAAGACATACACTAAGAATTTATGTAGATAATGTACTTTTATGAGATGTACAAGTAAGTGTCTTATCTGTACAGATGT AAATGTTGATGAAAATGCAATTGGGGTTAATATTTTAAGAATTCTTTAGTATATTCTTGGGTGTGGCTATATTACAAAATGGGATGCTGG CAATGAAACAATACATTTAACACTATTGTATTTTTATTATATGTAATTTAGTAATATGAATATAAATCTTGTAACTTTTAAAATTGTAAT GGAGGCTGTAATCATTTTATAATCTTTTTAATTTTAATGCAAGTACACTGGTGTTTATATTTGCACAAAGTATTGATATGTGATGTATTA AGTCACAAAAGTAAGCTGTGACATTGTCTATAAGCATTTGGCTCCACAAATGTATTTGGATTGTTTTCTATGTGAAGCAAACCAATTATA ATTAACCACATGTTGTAGTAACTGGTCTTTTTATATTTAAGCAGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAACAATACCTTTGAA CATTTTTGAATCACAGAATAGCGGTACCATGATAGAATACTGCAATTGTGGTCAGAATTACAGTATGCACAAAGAATTAATTAGCATTAT TAAAGAGTCCTCACTAAACATTTCATATGATCACACTGAAGAACTGTAACATTCCATAGAGTGAAGTGGTTCAAATTTCTCTTGGAATTT TTACTTTTGTTGGCCTTATTTTATGATCCTTTTCATATTTCTTTTGACTTAGAGTATTAATACATGGCCAAAATAATTTAGTTACTACCT CATACAAACAATATAATGGTTACTACACATCACAGGAACTTAGTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCCAATGGAATATGTA TATACCAGGTTTTAGCAAAATGCACACTTTTGGCTCTTTTTGGTATATGTTCTTTATATTTTAATGTGAGTATATACACTAAGAACAAAC TAAATTGTGATTTATGATCTTCATTTATTTTAATGATAATGGTTTTAAAATATGTTCCTGATTGTACATATTGTAAAATAAACATGTTTT >85262_85262_8_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000395038_MAP4K3_chr2_39542529_ENST00000341681_length(amino acids)=596AA_BP=29 MQAQQLPYEFFSEENAPKWRGLLVPALKKPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELDLQLEYGQGHQGGYF LGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRP PPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINP DTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPR KFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDF NQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGM -------------------------------------------------------------- >85262_85262_9_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000395038_MAP4K3_chr2_39542529_ENST00000437545_length(transcript)=3159nt_BP=115nt CCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGCCCAAGTGGCGGGG ACTACTGGTGCCTGCGCTGAAAAAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAGAAGAAAAAACACG CTCAGAGATAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTGATCTGCAACTGGAATA TGGACAAGGACACCAAGGTGGTTACTTTTTAGGTGCAAACAAGAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATCAGCGAGGACACGT CGCACATTTAGAAGATGATGAAGGAGATGATGATGAATCTAAACACTCAACTCTGAAAGCAAAAATTCCACCTCCTTTGCCACCAAAGCC TAAGTCTATCTTCATACCACAGGAAATGCATTCTACTGAGGATGAAAATCAAGGAACAATCAAGAGATGTCCCATGTCAGGGAGCCCAGC AAAGCCATCCCAAGTTCCACCTAGACCACCACCTCCCAGATTACCCCCACACAAACCTGTTGCCTTAGGAAATGGAATGAGCTCCTTCCA GTTAAATGGTGAACGAGATGGCTCATTATGTCAACAACAGAATGAACATAGAGGCACAAACCTTTCAAGAAAAGAAAAGAAAGATGTACC AAAGCCTATTAGTAATGGTCTTCCTCCAACACCTAAAGTGCATATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGTGTCCCTTGAAAAT TCACTGTGCATCATCATGGATAAACCCAGATACAAGAGATCAGTACTTGATATTTGGTGCCGAAGAAGGGATTTATACCCTCAATCTTAA TGAACTTCATGAAACATCAATGGAACAGCTATTCCCTCGAAGGTGTACATGGTTGTATGTAATGAACAATTGCTTGCTATCAATATCTGG TAAAGCTTCTCAGCTTTATTCCCATAATTTACCAGGGCTTTTTGATTATGCAAGACAAATGCAAAAGTTACCTGTTGCTATTCCAGCACA CAAACTCCCTGACAGAATACTGCCAAGGAAATTTTCTGTATCAGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGTGTTGTGTTGTAAG AAATCCTTACACGGGCCATAAATACCTATGTGGAGCACTTCAGACTAGCATTGTTCTATTAGAATGGGTTGAACCAATGCAGAAATTTAT GTTAATTAAGCACATAGATTTTCCTATACCATGTCCACTTAGAATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGTACCCTTTAGTTTG TGTTGGTGTCAGTAGAGGTAGAGACTTCAACCAAGTGGTTCGATTTGAGACGGTCAATCCAAATTCTACCTCTTCATGGTTTACAGAATC AGATACCCCACAGACAAATGTTACTCATGTAACCCAACTGGAGAGAGATACCATCCTTGTATGCTTGGACTGTTGTATAAAAATAGTAAA TCTCCAAGGAAGATTAAAATCTAGCAGGAAATTGTCATCAGAACTCACCTTTGATTTCCAGATTGAATCAATAGTGTGCCTACAAGACAG TGTGCTAGCTTTCTGGAAACATGGAATGCAAGGTAGAAGTTTTAGATCTAATGAGGTAACACAAGAAATTTCAGATAGCACAAGAATTTT CAGGCTGCTTGGATCTGACAGGGTCGTGGTTTTGGAAAGTAGGCCAACTGATAACCCCACAGCAAATAGCAATTTGTACATCCTGGCGGG TCATGAAAACAGTTACTGAGAATTGTTGTGCTTTGACAGTTAACTCTAGAAAGAAAGAACACTACCACTGCAACATTAATGGATGCTTGA AGCTGTACAAAAGCTGCAGTAACCTGTCTTCAGTTACTTTGTAATTTATTGTGGCATGAGATAAGATGGGGAAAATTTTGTTTTAAGTGG TATGGATATATTTAGCATATTGAACCACACAAGTGCTTAATTCATTGTTATGTAATCTTTGTACATATAGGCAGTATTTTTTCTGTGAAA CTTCATATTGCTGAAGACATACACTAAGAATTTATGTAGATAATGTACTTTTATGAGATGTACAAGTAAGTGTCTTATCTGTACAGATGT AAATGTTGATGAAAATGCAATTGGGGTTAATATTTTAAGAATTCTTTAGTATATTCTTGGGTGTGGCTATATTACAAAATGGGATGCTGG CAATGAAACAATACATTTAACACTATTGTATTTTTATTATATGTAATTTAGTAATATGAATATAAATCTTGTAACTTTTAAAATTGTAAT GGAGGCTGTAATCATTTTATAATCTTTTTAATTTTAATGCAAGTACACTGGTGTTTATATTTGCACAAAGTATTGATATGTGATGTATTA AGTCACAAAAGTAAGCTGTGACATTGTCTATAAGCATTTGGCTCCACAAATGTATTTGGATTGTTTTCTATGTGAAGCAAACCAATTATA ATTAACCACATGTTGTAGTAACTGGTCTTTTTATATTTAAGCAGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAACAATACCTTTGAA CATTTTTGAATCACAGAATAGCGGTACCATGATAGAATACTGCAATTGTGGTCAGAATTACAGTATGCACAAAGAATTAATTAGCATTAT TAAAGAGTCCTCACTAAACATTTCATATGATCACACTGAAGAACTGTAACATTCCATAGAGTGAAGTGGTTCAAATTTCTCTTGGAATTT TTACTTTTGTTGGCCTTATTTTATGATCCTTTTCATATTTCTTTTGACTTAGAGTATTAATACATGGCCAAAATAATTTAGTTACTACCT CATACAAACAATATAATGGTTACTACACATCACAGGAACTTAGTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCCAATGGAATATGTA TATACCAGGTTTTAGCAAAATGCACACTTTTGGCTCTTTTTGGTATATGTTCTTTATATTTTAATGTGAGTATATACACTAAGAACAAAC TAAATTGTGATTTATGATCTTCATTTATTTTAATGATAATGGTTTTAAAATATGTTCCTGATTGTACATATTGTAAAATAAACATGTTTT >85262_85262_9_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000395038_MAP4K3_chr2_39542529_ENST00000437545_length(amino acids)=596AA_BP=29 MQAQQLPYEFFSEENAPKWRGLLVPALKKPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELDLQLEYGQGHQGGYF LGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRP PPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINP DTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPR KFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDF NQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGM -------------------------------------------------------------- >85262_85262_10_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000402219_MAP4K3_chr2_39542529_ENST00000263881_length(transcript)=3247nt_BP=128nt CCGCCGCCCCTCTCCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGC CCAAGTGGCGGGGACTACTGGTGCCTGCGCTGAAAAAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAG AAGAAAAAACACGCTCAGAGATAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTCCCG ACAGTGATGGTTTTTTGGACAGTTCAGAAGAAATATACTACACTGCAAGATCTAATCTGGATCTGCAACTGGAATATGGACAAGGACACC AAGGTGGTTACTTTTTAGGTGCAAACAAGAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATCAGCGAGGACACGTCGCACATTTAGAAG ATGATGAAGGAGATGATGATGAATCTAAACACTCAACTCTGAAAGCAAAAATTCCACCTCCTTTGCCACCAAAGCCTAAGTCTATCTTCA TACCACAGGAAATGCATTCTACTGAGGATGAAAATCAAGGAACAATCAAGAGATGTCCCATGTCAGGGAGCCCAGCAAAGCCATCCCAAG TTCCACCTAGACCACCACCTCCCAGATTACCCCCACACAAACCTGTTGCCTTAGGAAATGGAATGAGCTCCTTCCAGTTAAATGGTGAAC GAGATGGCTCATTATGTCAACAACAGAATGAACATAGAGGCACAAACCTTTCAAGAAAAGAAAAGAAAGATGTACCAAAGCCTATTAGTA ATGGTCTTCCTCCAACACCTAAAGTGCATATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGTGTCCCTTGAAAATTCACTGTGCATCAT CATGGATAAACCCAGATACAAGAGATCAGTACTTGATATTTGGTGCCGAAGAAGGGATTTATACCCTCAATCTTAATGAACTTCATGAAA CATCAATGGAACAGCTATTCCCTCGAAGGTGTACATGGTTGTATGTAATGAACAATTGCTTGCTATCAATATCTGGTAAAGCTTCTCAGC TTTATTCCCATAATTTACCAGGGCTTTTTGATTATGCAAGACAAATGCAAAAGTTACCTGTTGCTATTCCAGCACACAAACTCCCTGACA GAATACTGCCAAGGAAATTTTCTGTATCAGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGTGTTGTGTTGTAAGAAATCCTTACACGG GCCATAAATACCTATGTGGAGCACTTCAGACTAGCATTGTTCTATTAGAATGGGTTGAACCAATGCAGAAATTTATGTTAATTAAGCACA TAGATTTTCCTATACCATGTCCACTTAGAATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGTACCCTTTAGTTTGTGTTGGTGTCAGTA GAGGTAGAGACTTCAACCAAGTGGTTCGATTTGAGACGGTCAATCCAAATTCTACCTCTTCATGGTTTACAGAATCAGATACCCCACAGA CAAATGTTACTCATGTAACCCAACTGGAGAGAGATACCATCCTTGTATGCTTGGACTGTTGTATAAAAATAGTAAATCTCCAAGGAAGAT TAAAATCTAGCAGGAAATTGTCATCAGAACTCACCTTTGATTTCCAGATTGAATCAATAGTGTGCCTACAAGACAGTGTGCTAGCTTTCT GGAAACATGGAATGCAAGGTAGAAGTTTTAGATCTAATGAGGTAACACAAGAAATTTCAGATAGCACAAGAATTTTCAGGCTGCTTGGAT CTGACAGGGTCGTGGTTTTGGAAAGTAGGCCAACTGATAACCCCACAGCAAATAGCAATTTGTACATCCTGGCGGGTCATGAAAACAGTT ACTGAGAATTGTTGTGCTTTGACAGTTAACTCTAGAAAGAAAGAACACTACCACTGCAACATTAATGGATGCTTGAAGCTGTACAAAAGC TGCAGTAACCTGTCTTCAGTTACTTTGTAATTTATTGTGGCATGAGATAAGATGGGGAAAATTTTGTTTTAAGTGGTATGGATATATTTA GCATATTGAACCACACAAGTGCTTAATTCATTGTTATGTAATCTTTGTACATATAGGCAGTATTTTTTCTGTGAAACTTCATATTGCTGA AGACATACACTAAGAATTTATGTAGATAATGTACTTTTATGAGATGTACAAGTAAGTGTCTTATCTGTACAGATGTAAATGTTGATGAAA ATGCAATTGGGGTTAATATTTTAAGAATTCTTTAGTATATTCTTGGGTGTGGCTATATTACAAAATGGGATGCTGGCAATGAAACAATAC ATTTAACACTATTGTATTTTTATTATATGTAATTTAGTAATATGAATATAAATCTTGTAACTTTTAAAATTGTAATGGAGGCTGTAATCA TTTTATAATCTTTTTAATTTTAATGCAAGTACACTGGTGTTTATATTTGCACAAAGTATTGATATGTGATGTATTAAGTCACAAAAGTAA GCTGTGACATTGTCTATAAGCATTTGGCTCCACAAATGTATTTGGATTGTTTTCTATGTGAAGCAAACCAATTATAATTAACCACATGTT GTAGTAACTGGTCTTTTTATATTTAAGCAGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAACAATACCTTTGAACATTTTTGAATCAC AGAATAGCGGTACCATGATAGAATACTGCAATTGTGGTCAGAATTACAGTATGCACAAAGAATTAATTAGCATTATTAAAGAGTCCTCAC TAAACATTTCATATGATCACACTGAAGAACTGTAACATTCCATAGAGTGAAGTGGTTCAAATTTCTCTTGGAATTTTTACTTTTGTTGGC CTTATTTTATGATCCTTTTCATATTTCTTTTGACTTAGAGTATTAATACATGGCCAAAATAATTTAGTTACTACCTCATACAAACAATAT AATGGTTACTACACATCACAGGAACTTAGTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCCAATGGAATATGTATATACCAGGTTTTA GCAAAATGCACACTTTTGGCTCTTTTTGGTATATGTTCTTTATATTTTAATGTGAGTATATACACTAAGAACAAACTAAATTGTGATTTA TGATCTTCATTTATTTTAATGATAATGGTTTTAAAATATGTTCCTGATTGTACATATTGTAAAATAAACATGTTTTTTAACATGCTGTTG >85262_85262_10_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000402219_MAP4K3_chr2_39542529_ENST00000263881_length(amino acids)=617AA_BP=29 MQAQQLPYEFFSEENAPKWRGLLVPALKKPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYY TARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQG TIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGAC FSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYAR QMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEM LVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFD -------------------------------------------------------------- >85262_85262_11_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000402219_MAP4K3_chr2_39542529_ENST00000341681_length(transcript)=3167nt_BP=128nt CCGCCGCCCCTCTCCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGC CCAAGTGGCGGGGACTACTGGTGCCTGCGCTGAAAAAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAG AAGAAAAAACACGCTCAGAGATAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTGATC TGCAACTGGAATATGGACAAGGACACCAAGGTGGTTACTTTTTAGGTGCAAACAAGAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATC AGCGAGGACACGTCGCACATTTAGAAGATGATGAAGGAGATGATGATGAATCTAAACACTCAACTCTGAAAGCAAAAATTCCACCTCCTT TGCCACCAAAGCCTAAGTCTATCTTCATACCACAGGAAATGCATTCTACTGAGGATGAAAATCAAGGAACAATCAAGAGATGTCCCATGT CAGGGAGCCCAGCAAAGCCATCCCAAGTTCCACCTAGACCACCACCTCCCAGATTACCCCCACACAAACCTGTTGCCTTAGGAAATGGAA TGAGCTCCTTCCAGTTAAATGGTGAACGAGATGGCTCATTATGTCAACAACAGAATGAACATAGAGGCACAAACCTTTCAAGAAAAGAAA AGAAAGATGTACCAAAGCCTATTAGTAATGGTCTTCCTCCAACACCTAAAGTGCATATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGT GTCCCTTGAAAATTCACTGTGCATCATCATGGATAAACCCAGATACAAGAGATCAGTACTTGATATTTGGTGCCGAAGAAGGGATTTATA CCCTCAATCTTAATGAACTTCATGAAACATCAATGGAACAGCTATTCCCTCGAAGGTGTACATGGTTGTATGTAATGAACAATTGCTTGC TATCAATATCTGGTAAAGCTTCTCAGCTTTATTCCCATAATTTACCAGGGCTTTTTGATTATGCAAGACAAATGCAAAAGTTACCTGTTG CTATTCCAGCACACAAACTCCCTGACAGAATACTGCCAAGGAAATTTTCTGTATCAGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGT GTTGTGTTGTAAGAAATCCTTACACGGGCCATAAATACCTATGTGGAGCACTTCAGACTAGCATTGTTCTATTAGAATGGGTTGAACCAA TGCAGAAATTTATGTTAATTAAGCACATAGATTTTCCTATACCATGTCCACTTAGAATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGT ACCCTTTAGTTTGTGTTGGTGTCAGTAGAGGTAGAGACTTCAACCAAGTGGTTCGATTTGAGACGGTCAATCCAAATTCTACCTCTTCAT GGTTTACAGAATCAGATACCCCACAGACAAATGTTACTCATGTAACCCAACTGGAGAGAGATACCATCCTTGTATGCTTGGACTGTTGTA TAAAAATAGTAAATCTCCAAGGAAGATTAAAATCTAGCAGGAAATTGTCATCAGAACTCACCTTTGATTTCCAGATTGAATCAATAGTGT GCCTACAAGACAGTGTGCTAGCTTTCTGGAAACATGGAATGCAAGGTAGAAGTTTTAGATCTAATGAGGTAACACAAGAAATTTCAGATA GCACAAGAATTTTCAGGCTGCTTGGATCTGACAGGGTCGTGGTTTTGGAAAGTAGGCCAACTGATAACCCCACAGCAAATAGCAATTTGT ACATCCTGGCGGGTCATGAAAACAGTTACTGAGAATTGTTGTGCTTTGACAGTTAACTCTAGAAAGAAAGAACACTACCACTGCAACATT AATGGATGCTTGAAGCTGTACAAAAGCTGCAGTAACCTGTCTTCAGTTACTTTGTAATTTATTGTGGCATGAGATAAGATGGGGAAAATT TTGTTTTAAGTGGTATGGATATATTTAGCATATTGAACCACACAAGTGCTTAATTCATTGTTATGTAATCTTTGTACATATAGGCAGTAT TTTTTCTGTGAAACTTCATATTGCTGAAGACATACACTAAGAATTTATGTAGATAATGTACTTTTATGAGATGTACAAGTAAGTGTCTTA TCTGTACAGATGTAAATGTTGATGAAAATGCAATTGGGGTTAATATTTTAAGAATTCTTTAGTATATTCTTGGGTGTGGCTATATTACAA AATGGGATGCTGGCAATGAAACAATACATTTAACACTATTGTATTTTTATTATATGTAATTTAGTAATATGAATATAAATCTTGTAACTT TTAAAATTGTAATGGAGGCTGTAATCATTTTATAATCTTTTTAATTTTAATGCAAGTACACTGGTGTTTATATTTGCACAAAGTATTGAT ATGTGATGTATTAAGTCACAAAAGTAAGCTGTGACATTGTCTATAAGCATTTGGCTCCACAAATGTATTTGGATTGTTTTCTATGTGAAG CAAACCAATTATAATTAACCACATGTTGTAGTAACTGGTCTTTTTATATTTAAGCAGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAA CAATACCTTTGAACATTTTTGAATCACAGAATAGCGGTACCATGATAGAATACTGCAATTGTGGTCAGAATTACAGTATGCACAAAGAAT TAATTAGCATTATTAAAGAGTCCTCACTAAACATTTCATATGATCACACTGAAGAACTGTAACATTCCATAGAGTGAAGTGGTTCAAATT TCTCTTGGAATTTTTACTTTTGTTGGCCTTATTTTATGATCCTTTTCATATTTCTTTTGACTTAGAGTATTAATACATGGCCAAAATAAT TTAGTTACTACCTCATACAAACAATATAATGGTTACTACACATCACAGGAACTTAGTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCC AATGGAATATGTATATACCAGGTTTTAGCAAAATGCACACTTTTGGCTCTTTTTGGTATATGTTCTTTATATTTTAATGTGAGTATATAC ACTAAGAACAAACTAAATTGTGATTTATGATCTTCATTTATTTTAATGATAATGGTTTTAAAATATGTTCCTGATTGTACATATTGTAAA >85262_85262_11_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000402219_MAP4K3_chr2_39542529_ENST00000341681_length(amino acids)=596AA_BP=29 MQAQQLPYEFFSEENAPKWRGLLVPALKKPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELDLQLEYGQGHQGGYF LGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRP PPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINP DTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPR KFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDF NQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGM -------------------------------------------------------------- >85262_85262_12_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000402219_MAP4K3_chr2_39542529_ENST00000437545_length(transcript)=3172nt_BP=128nt CCGCCGCCCCTCTCCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGC CCAAGTGGCGGGGACTACTGGTGCCTGCGCTGAAAAAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAG AAGAAAAAACACGCTCAGAGATAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTGATC TGCAACTGGAATATGGACAAGGACACCAAGGTGGTTACTTTTTAGGTGCAAACAAGAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATC AGCGAGGACACGTCGCACATTTAGAAGATGATGAAGGAGATGATGATGAATCTAAACACTCAACTCTGAAAGCAAAAATTCCACCTCCTT TGCCACCAAAGCCTAAGTCTATCTTCATACCACAGGAAATGCATTCTACTGAGGATGAAAATCAAGGAACAATCAAGAGATGTCCCATGT CAGGGAGCCCAGCAAAGCCATCCCAAGTTCCACCTAGACCACCACCTCCCAGATTACCCCCACACAAACCTGTTGCCTTAGGAAATGGAA TGAGCTCCTTCCAGTTAAATGGTGAACGAGATGGCTCATTATGTCAACAACAGAATGAACATAGAGGCACAAACCTTTCAAGAAAAGAAA AGAAAGATGTACCAAAGCCTATTAGTAATGGTCTTCCTCCAACACCTAAAGTGCATATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGT GTCCCTTGAAAATTCACTGTGCATCATCATGGATAAACCCAGATACAAGAGATCAGTACTTGATATTTGGTGCCGAAGAAGGGATTTATA CCCTCAATCTTAATGAACTTCATGAAACATCAATGGAACAGCTATTCCCTCGAAGGTGTACATGGTTGTATGTAATGAACAATTGCTTGC TATCAATATCTGGTAAAGCTTCTCAGCTTTATTCCCATAATTTACCAGGGCTTTTTGATTATGCAAGACAAATGCAAAAGTTACCTGTTG CTATTCCAGCACACAAACTCCCTGACAGAATACTGCCAAGGAAATTTTCTGTATCAGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGT GTTGTGTTGTAAGAAATCCTTACACGGGCCATAAATACCTATGTGGAGCACTTCAGACTAGCATTGTTCTATTAGAATGGGTTGAACCAA TGCAGAAATTTATGTTAATTAAGCACATAGATTTTCCTATACCATGTCCACTTAGAATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGT ACCCTTTAGTTTGTGTTGGTGTCAGTAGAGGTAGAGACTTCAACCAAGTGGTTCGATTTGAGACGGTCAATCCAAATTCTACCTCTTCAT GGTTTACAGAATCAGATACCCCACAGACAAATGTTACTCATGTAACCCAACTGGAGAGAGATACCATCCTTGTATGCTTGGACTGTTGTA TAAAAATAGTAAATCTCCAAGGAAGATTAAAATCTAGCAGGAAATTGTCATCAGAACTCACCTTTGATTTCCAGATTGAATCAATAGTGT GCCTACAAGACAGTGTGCTAGCTTTCTGGAAACATGGAATGCAAGGTAGAAGTTTTAGATCTAATGAGGTAACACAAGAAATTTCAGATA GCACAAGAATTTTCAGGCTGCTTGGATCTGACAGGGTCGTGGTTTTGGAAAGTAGGCCAACTGATAACCCCACAGCAAATAGCAATTTGT ACATCCTGGCGGGTCATGAAAACAGTTACTGAGAATTGTTGTGCTTTGACAGTTAACTCTAGAAAGAAAGAACACTACCACTGCAACATT AATGGATGCTTGAAGCTGTACAAAAGCTGCAGTAACCTGTCTTCAGTTACTTTGTAATTTATTGTGGCATGAGATAAGATGGGGAAAATT TTGTTTTAAGTGGTATGGATATATTTAGCATATTGAACCACACAAGTGCTTAATTCATTGTTATGTAATCTTTGTACATATAGGCAGTAT TTTTTCTGTGAAACTTCATATTGCTGAAGACATACACTAAGAATTTATGTAGATAATGTACTTTTATGAGATGTACAAGTAAGTGTCTTA TCTGTACAGATGTAAATGTTGATGAAAATGCAATTGGGGTTAATATTTTAAGAATTCTTTAGTATATTCTTGGGTGTGGCTATATTACAA AATGGGATGCTGGCAATGAAACAATACATTTAACACTATTGTATTTTTATTATATGTAATTTAGTAATATGAATATAAATCTTGTAACTT TTAAAATTGTAATGGAGGCTGTAATCATTTTATAATCTTTTTAATTTTAATGCAAGTACACTGGTGTTTATATTTGCACAAAGTATTGAT ATGTGATGTATTAAGTCACAAAAGTAAGCTGTGACATTGTCTATAAGCATTTGGCTCCACAAATGTATTTGGATTGTTTTCTATGTGAAG CAAACCAATTATAATTAACCACATGTTGTAGTAACTGGTCTTTTTATATTTAAGCAGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAA CAATACCTTTGAACATTTTTGAATCACAGAATAGCGGTACCATGATAGAATACTGCAATTGTGGTCAGAATTACAGTATGCACAAAGAAT TAATTAGCATTATTAAAGAGTCCTCACTAAACATTTCATATGATCACACTGAAGAACTGTAACATTCCATAGAGTGAAGTGGTTCAAATT TCTCTTGGAATTTTTACTTTTGTTGGCCTTATTTTATGATCCTTTTCATATTTCTTTTGACTTAGAGTATTAATACATGGCCAAAATAAT TTAGTTACTACCTCATACAAACAATATAATGGTTACTACACATCACAGGAACTTAGTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCC AATGGAATATGTATATACCAGGTTTTAGCAAAATGCACACTTTTGGCTCTTTTTGGTATATGTTCTTTATATTTTAATGTGAGTATATAC ACTAAGAACAAACTAAATTGTGATTTATGATCTTCATTTATTTTAATGATAATGGTTTTAAAATATGTTCCTGATTGTACATATTGTAAA >85262_85262_12_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000402219_MAP4K3_chr2_39542529_ENST00000437545_length(amino acids)=596AA_BP=29 MQAQQLPYEFFSEENAPKWRGLLVPALKKPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELDLQLEYGQGHQGGYF LGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRP PPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINP DTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPR KFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDF NQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGM -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for SOS1-MAP4K3 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for SOS1-MAP4K3 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for SOS1-MAP4K3 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SOS1 | C0028326 | Noonan Syndrome | 13 | CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET |
Hgene | SOS1 | C1853120 | Noonan Syndrome 4 | 11 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | SOS1 | C1275081 | Cardio-facio-cutaneous syndrome | 7 | CLINGEN |
Hgene | SOS1 | C0041409 | Turner Syndrome, Male | 2 | CTD_human |
Hgene | SOS1 | C1527404 | Female Pseudo-Turner Syndrome | 2 | CTD_human |
Hgene | SOS1 | C4551602 | Noonan Syndrome 1 | 2 | CTD_human |
Hgene | SOS1 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Hgene | SOS1 | C0399440 | Hereditary gingival fibromatosis | 1 | ORPHANET |
Hgene | SOS1 | C0587248 | Costello syndrome (disorder) | 1 | CLINGEN |