Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:SPTBN1-SPAG5 (FusionGDB2 ID:HG6711TG10615)

Fusion Gene Summary for SPTBN1-SPAG5

check button Fusion gene summary
Fusion gene informationFusion gene name: SPTBN1-SPAG5
Fusion gene ID: hg6711tg10615
HgeneTgene
Gene symbol

SPTBN1

SPAG5

Gene ID

6711

10615

Gene namespectrin beta, non-erythrocytic 1sperm associated antigen 5
SynonymsELF|HEL102|SPTB2|betaSpIIDEEPEST|MAP126|hMAP126
Cytomap('SPTBN1')('SPAG5')

2p16.2

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionspectrin beta chain, non-erythrocytic 1beta-G spectrinbeta-II spectrinbeta-fodrinbeta-spectrin 2beta-spectrin IIbeta-spectrin non-erythrocytic 1embryonic liver beta-fodrinepididymis luminal protein 102fodrin beta chainspectrin beta chain, brain sperm-associated antigen 5astrinmitotic spindle associated protein p126mitotic spindle coiled-coil related protein
Modification date2020032920200315
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000333896, ENST00000356805, 
Fusion gene scores* DoF score24 X 20 X 9=43205 X 7 X 5=175
# samples 268
** MAII scorelog2(26/4320*10)=-4.05444778402238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPTBN1 [Title/Abstract] AND SPAG5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSPTBN1(54826380)-SPAG5(26920084), # samples:4
Anticipated loss of major functional domain due to fusion event.SPTBN1-SPAG5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SPTBN1-SPAG5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SPTBN1-SPAG5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SPTBN1-SPAG5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SPTBN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SPAG5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A922-01ASPTBN1chr2

54826380

-SPAG5chr17

26920084

-
ChimerDB4STADTCGA-VQ-A922-01ASPTBN1chr2

54826380

+SPAG5chr17

26920084

-
ChimerDB4STADTCGA-VQ-A922SPTBN1chr2

54826380

+SPAG5chr17

26920084

-


Top

Fusion Gene ORF analysis for SPTBN1-SPAG5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000333896ENST00000321765SPTBN1chr2

54826380

+SPAG5chr17

26920084

-
In-frameENST00000356805ENST00000321765SPTBN1chr2

54826380

+SPAG5chr17

26920084

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356805SPTBN1chr254826380+ENST00000321765SPAG5chr1726920084-411158126639851239
ENST00000333896SPTBN1chr254826380+ENST00000321765SPAG5chr1726920084-417664631340501245

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356805ENST00000321765SPTBN1chr254826380+SPAG5chr1726920084-0.0051630660.9948369
ENST00000333896ENST00000321765SPTBN1chr254826380+SPAG5chr1726920084-0.0052952660.9947048

Top

Fusion Genomic Features for SPTBN1-SPAG5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for SPTBN1-SPAG5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:54826380/chr17:26920084)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSPAG5chr2:54826380chr17:26920084ENST00000321765124545_608591194.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG5chr2:54826380chr17:26920084ENST00000321765124759_868591194.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG5chr2:54826380chr17:26920084ENST00000321765124979_1174591194.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG5chr2:54826380chr17:26920084ENST00000321765124617_789591194.0Compositional biasNote=Gln-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+231173_278872156.0DomainCalponin-homology (CH) 2
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2312197_2307872156.0DomainPH
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+23154_158872156.0DomainCalponin-homology (CH) 1
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+336173_2781002365.0DomainCalponin-homology (CH) 2
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3362197_23071002365.0DomainPH
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+33654_1581002365.0DomainCalponin-homology (CH) 1
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2312_275872156.0RegionNote=Actin-binding
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3362_2751002365.0RegionNote=Actin-binding
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311063_1166872156.0RepeatSpectrin 8
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311170_1258872156.0RepeatSpectrin 9
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311276_1376872156.0RepeatSpectrin 10
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311381_1482872156.0RepeatSpectrin 11
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311486_1590872156.0RepeatSpectrin 12
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311592_1696872156.0RepeatSpectrin 13
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311698_1801872156.0RepeatSpectrin 14
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311805_1907872156.0RepeatSpectrin 15
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311914_2014872156.0RepeatSpectrin 16
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2312018_2097872156.0RepeatSpectrin 17
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+231303_411872156.0RepeatSpectrin 1
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+231423_525872156.0RepeatSpectrin 2
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+231530_636872156.0RepeatSpectrin 3
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+231639_742872156.0RepeatSpectrin 4
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+231745_847872156.0RepeatSpectrin 5
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+231850_952872156.0RepeatSpectrin 6
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+231957_1060872156.0RepeatSpectrin 7
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361063_11661002365.0RepeatSpectrin 8
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361170_12581002365.0RepeatSpectrin 9
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361276_13761002365.0RepeatSpectrin 10
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361381_14821002365.0RepeatSpectrin 11
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361486_15901002365.0RepeatSpectrin 12
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361592_16961002365.0RepeatSpectrin 13
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361698_18011002365.0RepeatSpectrin 14
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361805_19071002365.0RepeatSpectrin 15
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361914_20141002365.0RepeatSpectrin 16
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3362018_20971002365.0RepeatSpectrin 17
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+336303_4111002365.0RepeatSpectrin 1
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+336423_5251002365.0RepeatSpectrin 2
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+336530_6361002365.0RepeatSpectrin 3
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+336639_7421002365.0RepeatSpectrin 4
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+336745_8471002365.0RepeatSpectrin 5
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+336850_9521002365.0RepeatSpectrin 6
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+336957_10601002365.0RepeatSpectrin 7


Top

Fusion Gene Sequence for SPTBN1-SPAG5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>86140_86140_1_SPTBN1-SPAG5_SPTBN1_chr2_54826380_ENST00000333896_SPAG5_chr17_26920084_ENST00000321765_length(transcript)=4176nt_BP=646nt
GGTGTGCGCGCTGCGCCCGCGAGCTCCCGGGCTCGGCAACCGTGGCATGCTTAGGATTGGCCATATTTAAAAGTTCTGAAGTAGAACCTG
CGCCTCCTCTCTGCTTCTCCCTCCTCCTCAGTAATTTATTTCGAGCTTCCAGGCAAGGGCCACGGAAGAAGGGAAAGCAAGAAATTAGAT
GCCTGTGTGGTAACTCCTCGCGGAGCTAAGGTGGACTCTCTTGCAGCCAACTTCCCATCAGATCACCCTGCTGGACTTGCAGACCGGAAT
GGGGCTCGCCTAAGGAGCCGAGCGCTGCGGAGGCTGCTGCGTGTTGGATGGGAGTGGGAGGGGGCTGGAGCGAGATTTCCAGGGCGCAGT
CCTCCGGGGCGTTACGCCGGGCATAATGGAATTGCAGAGGACGTCTAGTATCTCCGGGCCGCTGTCGCCGGCGTACACGGGGCAGGTGCC
TTACAACTACAACCAGCTGGAAGGCAGATTCAAGCAGCTGCAAGATGAGCGTGAAGCCGTGCAGAAGAAGACCTTCACCAAGTGGGTCAA
TTCCCACCTTGCCCGTGTGTCCTGCCGGATCACAGACCTGTACACTGACCTTCGAGATGGACGGATGCTCATCAAGCTGCTGGAGGTCCT
CTCTGGAGAGAGGCTGGAAGGCAGCAACAACTCATCTCCAGTGGATTTTGTAAATAACAAGAGGACAGACTTATCTTCAGAACATTTCAG
TCATTCCTCAAAGTGGCTAGAAACTTGTCAGCATGAATCAGATGAGCAGCCTCTAGATCCAATTCCCCAAATTAGCTCTACTCCTAAAAC
GTCTGAGGAAGCAGTAGACCCACTGGGCAATTATATGGTTAAAACCATCGTCCTTGTACCATCTCCACTGGGGCAGCAACAAGACATGAT
ATTTGAGGCCCGTTTAGATACCATGGCAGAGACAAACAGCATATCTTTAAATGGACCTTTGAGAACAGACGATCTGGTGAGAGAGGAGGT
GGCACCCTGCATGGGAGACAGGTTTTCAGAAGTTGCTGCTGTATCTGAGAAACCTATCTTTCAGGAATCTCCGTCCCATCTCTTAGAGGA
GTCTCCACCAAATCCCTGTTCTGAACAACTACATTGCTCCAAGGAAAGCCTGAGCAGTAGAACTGAGGCTGTGCGTGAGGACTTAGTACC
TTCTGAAAGTAACGCCTTCTTGCCTTCCTCTGTTCTCTGGCTTTCCCCTTCAACTGCCTTGGCAGCAGATTTCCGTGTCAATCATGTGGA
CCCAGAGGAGGAAATTGTAGAGCATGGAGCTATGGAGGAAAGAGAAATGAGGTTTCCCACACATCCTAAGGAGTCTGAAACAGAAGATCA
AGCACTTGTCTCAAGTGTGGAAGATATTCTGTCCACATGCCTGACACCAAATCTAGTAGAAATGGAATCCCAAGAAGCTCCAGGCCCAGC
AGTAGAAGATGTTGGTAGGATTCTTGGCTCTGATACAGAGTCTTGGATGTCCCCACTGGCCTGGCTGGAAAAAGGTGTAAATACCTCCGT
CATGCTGGAAAATCTCCGCCAAAGCTTATCCCTTCCCTCGATGCTTCGGGATGCTGCAATTGGCACTACCCCTTTCTCTACTTGCTCGGT
GGGGACTTGGTTTACTCCTTCAGCACCACAGGAAAAGAGTACAAACACATCCCAGACAGGCCTGGTTGGCACCAAGCACAGTACTTCTGA
GACAGAGCAGCTCCTGTGTGGCCGGCCTCCAGATCTGACTGCCTTGTCTCGACATGACTTGGAAGATAACCTGCTGAGCTCTCTTGTCAT
TCTGGAGGTTCTCTCCCGCCAGCTTCGGGACTGGAAGAGCCAGCTGGCTGTCCCTCACCCAGAAACCCAGGACAGTAGCACACAGACTGA
CACATCTCACAGTGGGATAACTAATAAACTTCAGCATCTTAAGGAGAGCCATGAGATGGGACAGGCCCTACAGCAGGCCAGAAATGTCAT
GCAATCATGGGTGCTTATCTCTAAAGAGCTGATATCCTTGCTTCACCTATCCCTGTTGCATTTAGAAGAAGATAAGACTACTGTGAGTCA
GGAGTCTCGGCGTGCAGAAACATTGGTCTGTTGCTGTTTTGATTTGCTGAAGAAATTGAGGGCAAAGCTCCAGAGCCTCAAAGCAGAAAG
GGAGGAGGCAAGGCACAGAGAGGAAATGGCTCTCAGAGGCAAGGATGCGGCAGAGATAGTGTTGGAGGCTTTCTGTGCACACGCCAGCCA
GCGCATCAGCCAGCTGGAACAGGACCTAGCATCCATGCGGGAATTCAGAGGCCTTCTGAAGGATGCCCAGACCCAACTGGTAGGGCTTCA
TGCCAAGCAAGAAGAGCTGGTTCAGCAGACAGTGAGTCTTACTTCTACCTTGCAACAAGACTGGAGGTCCATGCAACTGGATTATACAAC
ATGGACAGCTTTGCTGAGTCGGTCCCGACAACTCACAGAGAAACTCACAGTCAAGAGCCAGCAAGCCCTGCAGGAACGTGATGTGGCAAT
TGAGGAAAAGCAGGAGGTTTCTAGGGTGCTGGAACAAGTCTCTGCCCAGTTAGAGGAGTGCAAAGGCCAAACAGAACAACTGGAGTTGGA
AAACAGTCGTCTAGCAACAGATCTCCGGGCTCAGTTGCAGATTCTGGCCAACATGGACAGCCAGCTAAAAGAGCTACAGAGTCAGCATAC
CCATTGTGCCCAGGACCTGGCTATGAAGGATGAGTTACTCTGCCAGCTTACCCAGAGCAATGAGGAGCAGGCTGCTCAATGGCAAAAGGA
AGAGATGGCACTAAAACACATGCAGGCAGAACTGCAGCAGCAACAAGCTGTCCTGGCCAAAGAGGTGCGGGACCTGAAAGAGACCTTGGA
GTTTGCAGACCAGGAGAATCAGGTTGCTCACCTGGAGCTGGGTCAGGTTGAGTGTCAATTGAAAACCACACTGGAAGTGCTCCGGGAGCG
CAGCTTGCAGTGTGAGAACCTCAAGGACACTGTAGAGAACCTAACGGCTAAACTGGCCAGCACCATAGCAGATAACCAGGAGCAAGATCT
GGAGAAAACACGGCAGTACTCTCAAAAGCTAGGGCTGCTGACTGAGCAACTACAGAGCCTGACTCTCTTTCTACAGACAAAACTAAAGGA
GAAGACTGAACAAGAGACCCTTCTGCTGAGTACAGCCTGTCCTCCCACCCAGGAACACCCTCTGCCTAATGACAGGACCTTCCTGGGAAG
CATCTTGACAGCAGTGGCAGATGAAGAGCCAGAATCAACTCCTGTGCCCTTGCTTGGAAGTGACAAGAGTGCTTTCACCCGAGTAGCATC
AATGGTTTCCCTTCAGCCCGCAGAGACCCCAGGCATGGAGGAGAGCCTGGCAGAAATGAGTATTATGACTACTGAGCTTCAGAGTCTTTG
TTCCCTGCTACAAGAGTCTAAAGAAGAAGCCATCAGGACTCTGCAGCGAAAAATTTGTGAGCTGCAAGCTAGGCTGCAGGCCCAGGAAGA
ACAGCATCAGGAAGTCCAGAAGGCAAAAGAAGCAGACATAGAGAAGCTGAACCAGGCCTTGTGCTTGCGCTACAAGAATGAAAAGGAGCT
CCAGGAAGTGATACAGCAGCAGAATGAGAAGATCCTAGAACAGATAGACAAGAGTGGCGAGCTCATAAGCCTTAGAGAGGAGGTGACCCA
CCTTACCCGCTCACTTCGGCGTGCGGAGACAGAGACCAAAGTGCTCCAGGAGGCCCTGGCAGGCCAGCTGGACTCCAACTGCCAGCCTAT
GGCCACCAATTGGATCCAGGAGAAAGTGTGGCTCTCTCAGGAGGTGGACAAACTGAGAGTGATGTTCCTGGAGATGAAAAATGAGAAGGA
AAAACTCATGATCAAGTTCCAGAGCCATAGAAATATCCTAGAGGAGAACCTTCGGCGCTCTGACAAGGAGTTAGAAAAACTAGATGACAT
TGTTCAGCATATTTATAAGACCCTGCTCTCTATTCCAGAGGTGGTGAGGGGATGCAAAGAACTACAGGGATTGCTGGAATTTCTGAGCTA
AGAAACTGAAAGCCAGAATCTGCTTCACCTCTTTTTACCTGCAATACCCCCTTACCCCAATACCAAGACCAACTGGCATAGAGCCAACTG

>86140_86140_1_SPTBN1-SPAG5_SPTBN1_chr2_54826380_ENST00000333896_SPAG5_chr17_26920084_ENST00000321765_length(amino acids)=1245AA_BP=111
MDGSGRGLERDFQGAVLRGVTPGIMELQRTSSISGPLSPAYTGQVPYNYNQLEGRFKQLQDEREAVQKKTFTKWVNSHLARVSCRITDLY
TDLRDGRMLIKLLEVLSGERLEGSNNSSPVDFVNNKRTDLSSEHFSHSSKWLETCQHESDEQPLDPIPQISSTPKTSEEAVDPLGNYMVK
TIVLVPSPLGQQQDMIFEARLDTMAETNSISLNGPLRTDDLVREEVAPCMGDRFSEVAAVSEKPIFQESPSHLLEESPPNPCSEQLHCSK
ESLSSRTEAVREDLVPSESNAFLPSSVLWLSPSTALAADFRVNHVDPEEEIVEHGAMEEREMRFPTHPKESETEDQALVSSVEDILSTCL
TPNLVEMESQEAPGPAVEDVGRILGSDTESWMSPLAWLEKGVNTSVMLENLRQSLSLPSMLRDAAIGTTPFSTCSVGTWFTPSAPQEKST
NTSQTGLVGTKHSTSETEQLLCGRPPDLTALSRHDLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLK
ESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGK
DAAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEK
LTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLC
QLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKDTVENL
TAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTP
VPLLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIE
KLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQE

--------------------------------------------------------------
>86140_86140_2_SPTBN1-SPAG5_SPTBN1_chr2_54826380_ENST00000356805_SPAG5_chr17_26920084_ENST00000321765_length(transcript)=4111nt_BP=581nt
GGAATCAGTGCCGCTGTTGCCGTGCAGGCTGCGGATTCCTCCAGTCCCTCCCTCGGCCGCCTCTCCTCCCGGAGCGAGCGCGCAGCCCTG
CGCAGCAGCGCCCACTGGTCCCGTCCTGTGAGCCCCGGCCCCAGCCGCGGACAGACCCGCGGAGTCGCCTCCCGGCCCACCCGCCCGGCC
GCCGAGGAGCGGGAGGAGGACGGGACCCCGGCGCCCCCACCCCATCCCCGGGAGAACTCTAAGAAGGAGCTGATGTGGAGGAGCAGCTGA
GACAGTTCAAGATGACGACCACAGTAGCCACAGACTATGACAACATTGAGATCCAGCAGCAGTACAGTGATGTCAACAACCGCTGGGATG
TCGACGACTGGGACAATGAGAACAGCTCTGCGCGGCTTTTTGAGCGGTCCCGCATCAAGGCTCTGGCAGATGAGCGTGAAGCCGTGCAGA
AGAAGACCTTCACCAAGTGGGTCAATTCCCACCTTGCCCGTGTGTCCTGCCGGATCACAGACCTGTACACTGACCTTCGAGATGGACGGA
TGCTCATCAAGCTGCTGGAGGTCCTCTCTGGAGAGAGGCTGGAAGGCAGCAACAACTCATCTCCAGTGGATTTTGTAAATAACAAGAGGA
CAGACTTATCTTCAGAACATTTCAGTCATTCCTCAAAGTGGCTAGAAACTTGTCAGCATGAATCAGATGAGCAGCCTCTAGATCCAATTC
CCCAAATTAGCTCTACTCCTAAAACGTCTGAGGAAGCAGTAGACCCACTGGGCAATTATATGGTTAAAACCATCGTCCTTGTACCATCTC
CACTGGGGCAGCAACAAGACATGATATTTGAGGCCCGTTTAGATACCATGGCAGAGACAAACAGCATATCTTTAAATGGACCTTTGAGAA
CAGACGATCTGGTGAGAGAGGAGGTGGCACCCTGCATGGGAGACAGGTTTTCAGAAGTTGCTGCTGTATCTGAGAAACCTATCTTTCAGG
AATCTCCGTCCCATCTCTTAGAGGAGTCTCCACCAAATCCCTGTTCTGAACAACTACATTGCTCCAAGGAAAGCCTGAGCAGTAGAACTG
AGGCTGTGCGTGAGGACTTAGTACCTTCTGAAAGTAACGCCTTCTTGCCTTCCTCTGTTCTCTGGCTTTCCCCTTCAACTGCCTTGGCAG
CAGATTTCCGTGTCAATCATGTGGACCCAGAGGAGGAAATTGTAGAGCATGGAGCTATGGAGGAAAGAGAAATGAGGTTTCCCACACATC
CTAAGGAGTCTGAAACAGAAGATCAAGCACTTGTCTCAAGTGTGGAAGATATTCTGTCCACATGCCTGACACCAAATCTAGTAGAAATGG
AATCCCAAGAAGCTCCAGGCCCAGCAGTAGAAGATGTTGGTAGGATTCTTGGCTCTGATACAGAGTCTTGGATGTCCCCACTGGCCTGGC
TGGAAAAAGGTGTAAATACCTCCGTCATGCTGGAAAATCTCCGCCAAAGCTTATCCCTTCCCTCGATGCTTCGGGATGCTGCAATTGGCA
CTACCCCTTTCTCTACTTGCTCGGTGGGGACTTGGTTTACTCCTTCAGCACCACAGGAAAAGAGTACAAACACATCCCAGACAGGCCTGG
TTGGCACCAAGCACAGTACTTCTGAGACAGAGCAGCTCCTGTGTGGCCGGCCTCCAGATCTGACTGCCTTGTCTCGACATGACTTGGAAG
ATAACCTGCTGAGCTCTCTTGTCATTCTGGAGGTTCTCTCCCGCCAGCTTCGGGACTGGAAGAGCCAGCTGGCTGTCCCTCACCCAGAAA
CCCAGGACAGTAGCACACAGACTGACACATCTCACAGTGGGATAACTAATAAACTTCAGCATCTTAAGGAGAGCCATGAGATGGGACAGG
CCCTACAGCAGGCCAGAAATGTCATGCAATCATGGGTGCTTATCTCTAAAGAGCTGATATCCTTGCTTCACCTATCCCTGTTGCATTTAG
AAGAAGATAAGACTACTGTGAGTCAGGAGTCTCGGCGTGCAGAAACATTGGTCTGTTGCTGTTTTGATTTGCTGAAGAAATTGAGGGCAA
AGCTCCAGAGCCTCAAAGCAGAAAGGGAGGAGGCAAGGCACAGAGAGGAAATGGCTCTCAGAGGCAAGGATGCGGCAGAGATAGTGTTGG
AGGCTTTCTGTGCACACGCCAGCCAGCGCATCAGCCAGCTGGAACAGGACCTAGCATCCATGCGGGAATTCAGAGGCCTTCTGAAGGATG
CCCAGACCCAACTGGTAGGGCTTCATGCCAAGCAAGAAGAGCTGGTTCAGCAGACAGTGAGTCTTACTTCTACCTTGCAACAAGACTGGA
GGTCCATGCAACTGGATTATACAACATGGACAGCTTTGCTGAGTCGGTCCCGACAACTCACAGAGAAACTCACAGTCAAGAGCCAGCAAG
CCCTGCAGGAACGTGATGTGGCAATTGAGGAAAAGCAGGAGGTTTCTAGGGTGCTGGAACAAGTCTCTGCCCAGTTAGAGGAGTGCAAAG
GCCAAACAGAACAACTGGAGTTGGAAAACAGTCGTCTAGCAACAGATCTCCGGGCTCAGTTGCAGATTCTGGCCAACATGGACAGCCAGC
TAAAAGAGCTACAGAGTCAGCATACCCATTGTGCCCAGGACCTGGCTATGAAGGATGAGTTACTCTGCCAGCTTACCCAGAGCAATGAGG
AGCAGGCTGCTCAATGGCAAAAGGAAGAGATGGCACTAAAACACATGCAGGCAGAACTGCAGCAGCAACAAGCTGTCCTGGCCAAAGAGG
TGCGGGACCTGAAAGAGACCTTGGAGTTTGCAGACCAGGAGAATCAGGTTGCTCACCTGGAGCTGGGTCAGGTTGAGTGTCAATTGAAAA
CCACACTGGAAGTGCTCCGGGAGCGCAGCTTGCAGTGTGAGAACCTCAAGGACACTGTAGAGAACCTAACGGCTAAACTGGCCAGCACCA
TAGCAGATAACCAGGAGCAAGATCTGGAGAAAACACGGCAGTACTCTCAAAAGCTAGGGCTGCTGACTGAGCAACTACAGAGCCTGACTC
TCTTTCTACAGACAAAACTAAAGGAGAAGACTGAACAAGAGACCCTTCTGCTGAGTACAGCCTGTCCTCCCACCCAGGAACACCCTCTGC
CTAATGACAGGACCTTCCTGGGAAGCATCTTGACAGCAGTGGCAGATGAAGAGCCAGAATCAACTCCTGTGCCCTTGCTTGGAAGTGACA
AGAGTGCTTTCACCCGAGTAGCATCAATGGTTTCCCTTCAGCCCGCAGAGACCCCAGGCATGGAGGAGAGCCTGGCAGAAATGAGTATTA
TGACTACTGAGCTTCAGAGTCTTTGTTCCCTGCTACAAGAGTCTAAAGAAGAAGCCATCAGGACTCTGCAGCGAAAAATTTGTGAGCTGC
AAGCTAGGCTGCAGGCCCAGGAAGAACAGCATCAGGAAGTCCAGAAGGCAAAAGAAGCAGACATAGAGAAGCTGAACCAGGCCTTGTGCT
TGCGCTACAAGAATGAAAAGGAGCTCCAGGAAGTGATACAGCAGCAGAATGAGAAGATCCTAGAACAGATAGACAAGAGTGGCGAGCTCA
TAAGCCTTAGAGAGGAGGTGACCCACCTTACCCGCTCACTTCGGCGTGCGGAGACAGAGACCAAAGTGCTCCAGGAGGCCCTGGCAGGCC
AGCTGGACTCCAACTGCCAGCCTATGGCCACCAATTGGATCCAGGAGAAAGTGTGGCTCTCTCAGGAGGTGGACAAACTGAGAGTGATGT
TCCTGGAGATGAAAAATGAGAAGGAAAAACTCATGATCAAGTTCCAGAGCCATAGAAATATCCTAGAGGAGAACCTTCGGCGCTCTGACA
AGGAGTTAGAAAAACTAGATGACATTGTTCAGCATATTTATAAGACCCTGCTCTCTATTCCAGAGGTGGTGAGGGGATGCAAAGAACTAC
AGGGATTGCTGGAATTTCTGAGCTAAGAAACTGAAAGCCAGAATCTGCTTCACCTCTTTTTACCTGCAATACCCCCTTACCCCAATACCA

>86140_86140_2_SPTBN1-SPAG5_SPTBN1_chr2_54826380_ENST00000356805_SPAG5_chr17_26920084_ENST00000321765_length(amino acids)=1239AA_BP=105
MRQFKMTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDG
RMLIKLLEVLSGERLEGSNNSSPVDFVNNKRTDLSSEHFSHSSKWLETCQHESDEQPLDPIPQISSTPKTSEEAVDPLGNYMVKTIVLVP
SPLGQQQDMIFEARLDTMAETNSISLNGPLRTDDLVREEVAPCMGDRFSEVAAVSEKPIFQESPSHLLEESPPNPCSEQLHCSKESLSSR
TEAVREDLVPSESNAFLPSSVLWLSPSTALAADFRVNHVDPEEEIVEHGAMEEREMRFPTHPKESETEDQALVSSVEDILSTCLTPNLVE
MESQEAPGPAVEDVGRILGSDTESWMSPLAWLEKGVNTSVMLENLRQSLSLPSMLRDAAIGTTPFSTCSVGTWFTPSAPQEKSTNTSQTG
LVGTKHSTSETEQLLCGRPPDLTALSRHDLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEMG
QALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIV
LEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQ
QALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSN
EEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKDTVENLTAKLAS
TIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGS
DKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQAL
CLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SPTBN1-SPAG5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneSPAG5chr2:54826380chr17:26920084ENST00000321765124482_85059.01194.0KNSTRN


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311563_209387.02156.0ANK2
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361563_2093100.02365.0ANK2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for SPTBN1-SPAG5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for SPTBN1-SPAG5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSPTBN1C0043094Weight Gain1CTD_human
TgeneC0000786Spontaneous abortion1CTD_human
TgeneC0000822Abortion, Tubal1CTD_human
TgeneC3830362Early Pregnancy Loss1CTD_human
TgeneC4552766Miscarriage1CTD_human