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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SPTBN1-SPEN (FusionGDB2 ID:HG6711TG23013)

Fusion Gene Summary for SPTBN1-SPEN

check button Fusion gene summary
Fusion gene informationFusion gene name: SPTBN1-SPEN
Fusion gene ID: hg6711tg23013
HgeneTgene
Gene symbol

SPTBN1

SPEN

Gene ID

6711

23013

Gene namespectrin beta, non-erythrocytic 1spen family transcriptional repressor
SynonymsELF|HEL102|SPTB2|betaSpIIHIAA0929|MINT|RBM15C|SHARP
Cytomap('SPTBN1')('SPEN')

2p16.2

1p36.21-p36.13

Type of geneprotein-codingprotein-coding
Descriptionspectrin beta chain, non-erythrocytic 1beta-G spectrinbeta-II spectrinbeta-fodrinbeta-spectrin 2beta-spectrin IIbeta-spectrin non-erythrocytic 1embryonic liver beta-fodrinepididymis luminal protein 102fodrin beta chainspectrin beta chain, brain msx2-interacting proteinMsx2 interacting nuclear target (MINT) homologSMART/HDAC1-associated repressor proteinnuclear receptor transcription cofactorspen homolog, transcriptional regulator
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000333896, ENST00000356805, 
Fusion gene scores* DoF score24 X 20 X 9=43206 X 7 X 3=126
# samples 268
** MAII scorelog2(26/4320*10)=-4.05444778402238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/126*10)=-0.655351828612554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPTBN1 [Title/Abstract] AND SPEN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSPTBN1(54853321)-SPEN(16245519), # samples:1
Anticipated loss of major functional domain due to fusion event.SPTBN1-SPEN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SPTBN1-SPEN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SPTBN1-SPEN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SPTBN1-SPEN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSPEN

GO:0000122

negative regulation of transcription by RNA polymerase II

16287852

TgeneSPEN

GO:0045892

negative regulation of transcription, DNA-templated

16129689


check buttonFusion gene breakpoints across SPTBN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SPEN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABE938281SPTBN1chr2

54853321

-SPENchr1

16245519

+


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Fusion Gene ORF analysis for SPTBN1-SPEN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000333896ENST00000471538SPTBN1chr2

54853321

-SPENchr1

16245519

+
5CDS-intronENST00000356805ENST00000471538SPTBN1chr2

54853321

-SPENchr1

16245519

+
In-frameENST00000333896ENST00000375759SPTBN1chr2

54853321

-SPENchr1

16245519

+
In-frameENST00000356805ENST00000375759SPTBN1chr2

54853321

-SPENchr1

16245519

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356805SPTBN1chr254853321-ENST00000375759SPENchr116245519+1220616721588111723194
ENST00000333896SPTBN1chr254853321-ENST00000375759SPENchr116245519+1227117371653112373194

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356805ENST00000375759SPTBN1chr254853321-SPENchr116245519+0.0044054050.99559456
ENST00000333896ENST00000375759SPTBN1chr254853321-SPENchr116245519+0.0044707140.99552935

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Fusion Genomic Features for SPTBN1-SPEN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for SPTBN1-SPEN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:54853321/chr1:16245519)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSPENchr2:54853321chr1:16245519ENST000003757590151170_119103665.0Coiled coilOntology_term=ECO:0000255
TgeneSPENchr2:54853321chr1:16245519ENST000003757590151408_142803665.0Coiled coilOntology_term=ECO:0000255
TgeneSPENchr2:54853321chr1:16245519ENST000003757590151496_152903665.0Coiled coilOntology_term=ECO:0000255
TgeneSPENchr2:54853321chr1:16245519ENST000003757590151592_161203665.0Coiled coilOntology_term=ECO:0000255
TgeneSPENchr2:54853321chr1:16245519ENST000003757590151928_194403665.0Coiled coilOntology_term=ECO:0000255
TgeneSPENchr2:54853321chr1:16245519ENST00000375759015688_71503665.0Coiled coilOntology_term=ECO:0000255
TgeneSPENchr2:54853321chr1:16245519ENST00000375759015977_100403665.0Coiled coilOntology_term=ECO:0000255
TgeneSPENchr2:54853321chr1:16245519ENST00000375759015125_27703665.0Compositional biasNote=Arg-rich
TgeneSPENchr2:54853321chr1:16245519ENST00000375759015240_32503665.0Compositional biasNote=Ser-rich
TgeneSPENchr2:54853321chr1:16245519ENST000003757590152428_252003665.0Compositional biasNote=Pro-rich
TgeneSPENchr2:54853321chr1:16245519ENST000003757590153220_348203665.0Compositional biasNote=Pro-rich
TgeneSPENchr2:54853321chr1:16245519ENST00000375759015616_81003665.0Compositional biasNote=Arg-rich
TgeneSPENchr2:54853321chr1:16245519ENST00000375759015624_69703665.0Compositional biasNote=Tyr-rich
TgeneSPENchr2:54853321chr1:16245519ENST000003757590151_57303665.0DNA bindingOntology_term=ECO:0000250
TgeneSPENchr2:54853321chr1:16245519ENST000003757590152201_270703665.0DomainNote=RID
TgeneSPENchr2:54853321chr1:16245519ENST00000375759015335_41503665.0DomainRRM 2
TgeneSPENchr2:54853321chr1:16245519ENST000003757590153498_366403665.0DomainSPOC
TgeneSPENchr2:54853321chr1:16245519ENST00000375759015438_51303665.0DomainRRM 3
TgeneSPENchr2:54853321chr1:16245519ENST00000375759015517_58903665.0DomainRRM 4
TgeneSPENchr2:54853321chr1:16245519ENST000003757590156_8103665.0DomainRRM 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-131173_27802156.0DomainCalponin-homology (CH) 2
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1312197_230702156.0DomainPH
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-13154_15802156.0DomainCalponin-homology (CH) 1
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-136173_27802365.0DomainCalponin-homology (CH) 2
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1362197_230702365.0DomainPH
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-13654_15802365.0DomainCalponin-homology (CH) 1
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1312_27502156.0RegionNote=Actin-binding
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1362_27502365.0RegionNote=Actin-binding
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1311063_116602156.0RepeatSpectrin 8
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1311170_125802156.0RepeatSpectrin 9
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1311276_137602156.0RepeatSpectrin 10
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1311381_148202156.0RepeatSpectrin 11
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1311486_159002156.0RepeatSpectrin 12
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1311592_169602156.0RepeatSpectrin 13
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1311698_180102156.0RepeatSpectrin 14
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1311805_190702156.0RepeatSpectrin 15
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1311914_201402156.0RepeatSpectrin 16
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1312018_209702156.0RepeatSpectrin 17
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-131303_41102156.0RepeatSpectrin 1
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-131423_52502156.0RepeatSpectrin 2
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-131530_63602156.0RepeatSpectrin 3
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-131639_74202156.0RepeatSpectrin 4
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-131745_84702156.0RepeatSpectrin 5
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-131850_95202156.0RepeatSpectrin 6
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-131957_106002156.0RepeatSpectrin 7
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1361063_116602365.0RepeatSpectrin 8
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1361170_125802365.0RepeatSpectrin 9
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1361276_137602365.0RepeatSpectrin 10
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1361381_148202365.0RepeatSpectrin 11
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1361486_159002365.0RepeatSpectrin 12
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1361592_169602365.0RepeatSpectrin 13
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1361698_180102365.0RepeatSpectrin 14
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1361805_190702365.0RepeatSpectrin 15
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1361914_201402365.0RepeatSpectrin 16
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1362018_209702365.0RepeatSpectrin 17
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-136303_41102365.0RepeatSpectrin 1
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-136423_52502365.0RepeatSpectrin 2
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-136530_63602365.0RepeatSpectrin 3
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-136639_74202365.0RepeatSpectrin 4
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-136745_84702365.0RepeatSpectrin 5
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-136850_95202365.0RepeatSpectrin 6
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-136957_106002365.0RepeatSpectrin 7


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Fusion Gene Sequence for SPTBN1-SPEN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>86141_86141_1_SPTBN1-SPEN_SPTBN1_chr2_54853321_ENST00000333896_SPEN_chr1_16245519_ENST00000375759_length(transcript)=12271nt_BP=1737nt
GGTGTGCGCGCTGCGCCCGCGAGCTCCCGGGCTCGGCAACCGTGGCATGCTTAGGATTGGCCATATTTAAAAGTTCTGAAGTAGAACCTG
CGCCTCCTCTCTGCTTCTCCCTCCTCCTCAGTAATTTATTTCGAGCTTCCAGGCAAGGGCCACGGAAGAAGGGAAAGCAAGAAATTAGAT
GCCTGTGTGGTAACTCCTCGCGGAGCTAAGGTGGACTCTCTTGCAGCCAACTTCCCATCAGATCACCCTGCTGGACTTGCAGACCGGAAT
GGGGCTCGCCTAAGGAGCCGAGCGCTGCGGAGGCTGCTGCGTGTTGGATGGGAGTGGGAGGGGGCTGGAGCGAGATTTCCAGGGCGCAGT
CCTCCGGGGCGTTACGCCGGGCATAATGGAATTGCAGAGGACGTCTAGTATCTCCGGGCCGCTGTCGCCGGCGTACACGGGGCAGGTGCC
TTACAACTACAACCAGCTGGAAGGCAGATTCAAGCAGCTGCAAGATGAGCGTGAAGCCGTGCAGAAGAAGACCTTCACCAAGTGGGTCAA
TTCCCACCTTGCCCGTGTGTCCTGCCGGATCACAGACCTGTACACTGACCTTCGAGATGGACGGATGCTCATCAAGCTGCTGGAGGTCCT
CTCTGGAGAGAGGCTGCCTAAACCCACCAAGGGACGAATGCGCATCCACTGCTTAGAGAATGTGGACAAGGCCCTTCAGTTCCTGAAGGA
GCAGAGAGTCCATCTTGAGAACATGGGGTCCCATGACATCGTGGATGGAAACCACCGGCTGACCCTTGGCCTCATCTGGACCATCATCCT
GCGCTTCCAGATCCAGGATATCAGTGTGGAAACTGAAGACAACAAAGAGAAGAAATCTGCCAAGGATGCATTGCTGTTGTGGTGCCAGAT
GAAGACAGCTGGGTACCCCAATGTCAACATTCACAATTTCACCACTAGCTGGAGGGACGGCATGGCCTTCAATGCACTGATACACAAACA
CCGGCCTGACCTGATAGATTTTGACAAACTAAAGAAATCTAACGCACACTACAACCTGCAGAATGCATTTAATCTGGCAGAACAGCACCT
CGGCCTCACTAAACTGTTGGACCCCGAAGACATCAGCGTGGACCATCCTGATGAGAAGTCCATAATCACTTATGTGGTGACTTATTACCA
CTACTTCTCTAAGATGAAGGCCTTAGCTGTTGAAGGAAAACGAATTGGAAAGGTGCTTGACAATGCTATTGAAACAGAAAAAATGATTGA
AAAGTATGAATCACTTGCCTCTGACCTTCTGGAATGGATTGAACAAACCATCATCATTCTGAACAATCGCAAATTTGCCAATTCACTGGT
CGGGGTTCAACAGCAGCTTCAGGCATTCAACACTTACCGCACTGTGGAGAAACCACCCAAATTTACTGAGAAGGGGAACTTGGAAGTGCT
GCTCTTCACCATTCAGAGCAAGATGAGGGCCAACAACCAGAAGGTCTACATGCCCCGGGAGGGGAAGCTCATCTCTGACATCAACAAGGC
CTGGGAAAGACTGGAAAAAGCGGAACACGAAAGAGAACTGGCTTTGCGGAATGAGCTCATAAGACAGGAGAAACTGGAACAGCTCGCCCG
CAGATTTGATCGCAAGGCAGCTATGAGGGAGACTTGGCTGAGCGAAAACCAGCGTCTGGTGTCTCAGAGATATTCCAGGAAATGCTCTAC
ATTATGGACTGGATGGATGAAATGAAGGAATATCTTGGAAATAATCGCCTCAAGCTGGGTTTTGGAAAGAGCATGCCTACAAACTGCGTG
TGGCTAGATGGGCTTTCTTCGAATGTGTCAGATCAGTATTTAACACGACATTTCTGCCGATATGGGCCTGTGGTAAAGGTGGTGTTTGAC
CGCTTAAAAGGCATGGCCCTGGTTCTCTACAATGAAATTGAATATGCACAAGCAGCTGTAAAAGAGACCAAAGGGAGGAAAATCGGTGGG
AATAAAATTAAGGTGGATTTTGCAAATCGGGAAAGTCAGCTGGCTTTTTATCACTGCATGGAGAAATCTGGTCAAGACATCAGAGACTTT
TATGAAATGTTAGCCGAAAGAAGAGAGGAACGAAGGGCATCCTACGACTATAACCAAGATCGTACATATTATGAGAGTGTTCGAACTCCA
GGCACTTATCCTGAGGATTCCAGGCGGGACTATCCAGCTCGAGGGAGAGAGTTTTATTCAGAATGGGAAACTTACCAAGGAGACTACTAT
GAATCACGATACTACGATGATCCTCGGGAATACAGGGATTACAGGAATGATCCTTATGAACAAGATATTAGGGAATATAGTTACAGGCAA
AGGGAACGAGAAAGAGAACGTGAAAGATTTGAGTCTGACCGGGACAGAGACCATGAGAGGAGGCCGATTGAACGAAGTCAAAGTCCTGTT
CACTTGCGACGTCCACAGAGTCCTGGAGCGTCTCCCTCTCAGGCAGAGAGGTTGCCGAGTGATTCTGAGAGGAGGCTTTACAGCCGATCC
TCAGACCGGAGTGGAAGCTGTAGCTCACTCTCCCCTCCAAGATATGAGAAACTGGACAAGTCTCGTTTGGAGCGCTATACAAAAAATGAA
AAGACAGATAAAGAACGAACTTTTGATCCGGAGAGAGTGGAGAGAGAGAGACGCTTAATACGGAAGGAAAAAGTGGAAAAGGACAAAACT
GACAAGCAGAAACGCAAAGGAAAGGTTCACTCCCCTAGTTCTCAGTCTTCAGAAACGGACCAAGAAAATGAGCGAGAGCAAAGCCCTGAA
AAGCCCAGGAGTTGTAATAAACTGAGCAGAGAGAAAGCTGACAAAGAGGGAATAGCGAAAAACCGCCTGGAACTCATGCCTTGCGTGGTT
TTGACTCGAGTGAAAGAGAAAGAGGGAAAGGTCATTGACCACACTCCTGTGGAAAAGTTGAAAGCCAAGCTTGATAATGACACTGTCAAA
TCTTCTGCCCTGGACCAGAAACTTCAGGTCTCTCAGACGGAGCCTGCAAAATCTGACTTGTCTAAACTGGAATCAGTTAGAATGAAAGTA
CCAAAGGAAAAGGGGCTTTCAAGCCATGTTGAAGTGGTGGAGAAGGAAGGCAGGCTTAAAGCCAGGAAGCACCTCAAGCCTGAGCAGCCT
GCAGATGGGGTAAGTGCTGTGGATCTGGAGAAGCTGGAAGCCAGGAAAAGGCGCTTTGCAGATTCCAATTTAAAAGCAGAAAAGCAAAAA
CCAGAGGTCAAGAAAAGCAGTCCAGAGATGGAGGATGCTCGCGTGCTTTCAAAAAAGCAGCCTGACGTGTCCTCTAGAGAGGTCATTCTG
CTGAGGGAAGGAGAGGCTGAAAGAAAGCCTGTGAGGAAAGAAATTCTTAAAAGAGAATCTAAAAAAATCAAACTGGACAGACTTAATACT
GTTGCCAGCCCCAAAGACTGTCAGGAGCTTGCCAGTATTTCTGTTGGGTCTGGCTCAAGGCCCAGCTCAGACCTACAAGCAAGACTGGGA
GAACTAGCAGGTGAATCTGTGGAAAATCAAGAAGTCCAATCAAAAAAGCCCATTCCCTCAAAACCACAGCTCAAACAGCTGCAGGTATTA
GATGATCAAGGACCAGAGAGAGAAGACGTTAGGAAAAACTATTGCAGTCTTCGTGATGAAACACCTGAACGTAAATCAGGCCAAGAGAAA
TCACATTCAGTAAATACTGAAGAAAAAATTGGCATTGACATCGATCACACGCAGAGTTACCGAAAACAAATGGAACAGAGTCGTAGGAAA
CAGCAGATGGAAATGGAAATAGCCAAGTCTGAGAAGTTTGGCAGTCCTAAAAAAGATGTAGATGAATATGAAAGACGTAGCCTCGTTCAC
GAGGTAGGCAAACCCCCTCAAGATGTCACTGATGACTCTCCTCCTAGCAAAAAGAAAAGGATGGATCATGTCGATTTTGATATCTGCACC
AAGCGAGAACGGAATTACAGAAGTTCACGCCAAATCAGCGAAGATTCTGAAAGGACTGGTGGTTCTCCCAGTGTCCGACATGGTTCCTTC
CATGAAGATGAGGATCCCATAGGCTCCCCTAGGCTACTGTCAGTAAAAGGGTCTCCTAAAGTAGATGAAAAAGTCCTCCCCTATTCTAAC
ATAACAGTCAGGGAAGAGTCTTTAAAATTTAATCCTTATGATTCTAGCAGGAGAGAACAGATGGCAGATATGGCCAAAATAAAACTATCT
GTCTTGAATTCTGAAGATGAACTAAATCGTTGGGACTCTCAGATGAAACAGGATGCTGGCAGATTTGATGTGAGTTTCCCAAACAGCATA
ATTAAGAGAGATAGCCTTCGAAAAAGGTCTGTACGAGATCTGGAACCTGGTGAGGTGCCTTCTGATTCTGACGAAGATGGTGAACACAAA
TCCCACTCACCCAGAGCCTCTGCATTATATGAAAGTTCTCGATTGTCTTTTTTATTGAGGGACAGAGAAGACAAGCTACGTGAGCGAGAT
GAAAGACTCTCTAGTTCTTTAGAAAGGAACAAATTTTACTCTTTTGCATTGGATAAGACAATCACACCAGACACTAAAGCTTTGCTTGAA
AGAGCTAAATCCCTCTCTTCATCTCGTGAAGAAAATTGGTCTTTTCTTGATTGGGACTCCCGATTTGCAAATTTTCGAAACAACAAAGAT
AAAGAAAAGGTTGACTCTGCTCCAAGACCTATTCCATCCTGGTACATGAAAAAGAAGAAAATTAGGACTGATTCAGAAGGGAAAATGGAT
GATAAGAAAGAGGACCATAAAGAAGAAGAGCAAGAGAGGCAGGAATTGTTTGCTTCTCGTTTTTTACACAGCTCAATCTTTGAACAAGAT
TCCAAGCGATTGCAGCATCTAGAGAGAAAAGAGGAAGATTCTGACTTCATTTCTGGTAGGATCTATGGGAAGCAGACATCTGAGGGAGCA
AACAGCACAACTGATTCCATTCAAGAACCAGTAGTTCTGTTCCATAGCAGATTTATGGAGCTCACACGGATGCAACAGAAAGAAAAAGAA
AAAGACCAGAAACCCAAAGAGGTTGAGAAACAGGAAGATACAGAGAATCATCCCAAGACCCCAGAATCTGCTCCTGAGAATAAAGATTCA
GAACTGAAAACTCCACCTTCCGTTGGGCCTCCAAGTGTCACAGTCGTAACTCTAGAATCAGCCCCATCAGCACTAGAGAAGACCACTGGT
GACAAAACGGTAGAGGCGCCTTTGGTAACAGAAGAGAAGACTGTGGAGCCAGCTACCGTCTCAGAAGAAGCAAAGCCTGCATCTGAACCT
GCTCCTGCCCCTGTGGAACAGCTGGAACAAGTAGACCTGCCCCCAGGAGCAGACCCCGATAAAGAAGCTGCCATGATGCCTGCGGGTGTT
GAGGAAGGTTCATCAGGTGACCAGCCGCCTTATCTGGATGCCAAGCCTCCAACTCCCGGGGCCTCGTTTTCCCAGGCAGAGAGCAACGTA
GATCCAGAGCCTGACAGTACCCAGCCACTTTCAAAACCAGCTCAGAAGTCTGAGGAAGCCAATGAGCCAAAGGCCGAAAAGCCAGACGCC
ACTGCAGATGCTGAGCCTGATGCAAACCAGAAAGCCGAAGCTGCTCCTGAGTCTCAGCCCCCAGCTTCTGAAGATTTAGAGGTTGATCCT
CCAGTTGCTGCAAAGGATAAAAAGCCAAACAAAAGCAAGCGTTCAAAGACCCCTGTTCAGGCAGCTGCAGTGAGTATCGTGGAGAAGCCC
GTCACAAGGAAGAGTGAGAGGATAGACCGGGAAAAACTCAAGCGGTCCAATTCTCCTCGGGGAGAAGCACAGAAGCTTTTGGAATTGAAG
ATGGAGGCAGAGAAGATTACAAGGACTGCTTCTAAAAACTCTGCTGCAGACCTTGAACATCCCGAACCAAGTTTGCCTCTCAGCCGAACA
AGGCGCCGGAATGTAAGGAGCGTCTATGCAACCATGGGTGACCATGAAAACCGCTCTCCTGTCAAAGAGCCCGTTGAGCAACCAAGAGTG
ACCAGAAAGAGATTGGAGCGAGAGCTTCAGGAGGCTGCAGCGGTTCCCACCACCCCTCGGAGGGGAAGGCCTCCAAAGACACGCCGGCGA
GCCGATGAAGAGGAGGAGAACGAGGCCAAGGAACCTGCAGAAACACTCAAGCCACCTGAGGGATGGCGGTCGCCAAGGTCCCAGAAAACT
GCAGCTGGTGGTGGACCCCAAGGGAAAAAGGGAAAAAATGAACCGAAGGTGGATGCTACACGTCCTGAGGCCACCACTGAGGTGGGCCCC
CAAATAGGCGTGAAAGAGAGCTCCATGGAACCCAAGGCTGCTGAGGAGGAGGCAGGGAGTGAACAGAAACGTGACAGAAAAGATGCTGGC
ACAGACAAAAACCCCCCTGAAACCGCCCCTGTTGAAGTTGTAGAGAAAAAACCGGCCCCTGAAAAAAACTCCAAATCAAAGAGAGGAAGA
TCTCGAAACTCCAGGTTAGCAGTGGACAAATCTGCAAGTCTGAAAAATGTGGATGCTGCTGTCAGTCCCAGGGGGGCTGCAGCACAGGCA
GGGGAGAGGGAATCTGGGGTGGTGGCAGTCTCCCCTGAGAAAAGTGAGAGTCCCCAAAAGGAGGATGGTTTATCATCCCAGTTGAAAAGT
GATCCAGTTGATCCAGACAAGGAACCAGAGAAAGAAGACGTGTCTGCCTCTGGGCCGTCCCCAGAAGCCACCCAGTTAGCCAAGCAGATG
GAGCTGGAGCAGGCCGTGGAACACATCGCAAAGCTCGCTGAGGCCTCTGCCTCTGCTGCCTATAAGGCAGATGCACCAGAGGGCCTTGCC
CCAGAGGACAGGGACAAGCCTGCACACCAAGCAAGTGAAACAGAGCTGGCTGCGGCCATCGGCTCCATCATCAATGACATTTCTGGGGAG
CCAGAAAACTTCCCAGCACCTCCACCTTATCCTGGAGAATCCCAGACAGATCTGCAACCCCCCGCAGGTGCACAGGCGCTGCAGCCTTCT
GAGGAAGGAATGGAGACAGATGAGGCTGTATCTGGCATCCTGGAAACTGAGGCTGCTACAGAATCTTCTAGGCCTCCAGTCAATGCTCCT
GACCCCTCAGCCGGCCCAACAGATACCAAGGAAGCCAGAGGAAATAGCAGTGAAACCTCACACTCAGTGCCAGAAGCCAAAGGGTCTAAA
GAAGTGGAAGTCACTCTTGTTCGGAAAGACAAAGGGCGCCAGAAAACAACCCGATCACGCCGCAAGCGAAACACAAACAAGAAAGTGGTG
GCTCCTGTAGAGAGCCATGTCCCTGAATCCAACCAAGCTCAAGGTGAGAGTCCTGCTGCAAATGAGGGGACAACAGTACAGCACCCCGAA
GCCCCACAGGAAGAAAAGCAGAGTGAGAAACCCCATTCCACTCCTCCTCAGTCATGTACTTCTGACCTAAGCAAGATTCCCTCCACAGAG
AATTCGTCCCAAGAAATCAGTGTTGAGGAAAGGACTCCAACCAAAGCATCTGTGCCCCCAGACCTTCCCCCACCTCCCCAGCCAGCACCG
GTGGATGAGGAGCCTCAAGCCAGGTTCAGGGTGCATTCCATCATTGAAAGTGACCCGGTGACCCCACCCAGCGATCCAAGCATCCCCATA
CCCACACTGCCTTCTGTAACTGCAGCAAAGCTCTCACCTCCTGTCGCCTCTGGGGGGATCCCACACCAGAGCCCCCCTACTAAGGTGACA
GAGTGGATCACAAGGCAGGAGGAGCCACGGGCTCAGTCTACTCCATCTCCAGCTCTTCCCCCAGACACAAAGGCCTCTGATGTTGACACC
AGCTCCAGCACCCTGAGGAAGATTCTCATGGACCCCAAGTATGTGTCTGCCACAAGTGTCACTTCCACAAGTGTCACCACAGCCATTGCA
GAGCCTGTCAGTGCTGCCCCTTGCCTACATGAGGCCCCGCCCCCGCCAGTTGACTCTAAAAAGCCTTTAGAAGAAAAAACAGCACCTCCA
GTGACAAACAACTCTGAGATACAAGCCTCGGAGGTGCTGGTAGCTGCTGACAAGGAAAAGGTGGCTCCAGTCATTGCTCCCAAAATTACC
TCTGTTATTAGCCGGATGCCTGTCAGCATTGACCTGGAAAATTCACAGAAGATAACCTTGGCAAAACCAGCTCCTCAAACCCTCACTGGT
CTGGTGAGCGCACTCACTGGCCTGGTGAACGTCTCCCTGGTCCCGGTGAATGCCCTGAAAGGCCCCGTGAAGGGCTCAGTGACCACACTG
AAAAGTTTGGTGAGCACCCCTGCTGGGCCCGTGAACGTCCTGAAAGGGCCTGTGAATGTTCTTACGGGGCCAGTGAATGTTCTCACCACT
CCAGTGAACGCCACGGTGGGCACAGTGAATGCCGCCCCAGGCACAGTCAATGCCGCTGCGAGTGCAGTGAATGCCACAGCAAGTGCAGTG
ACCGTCACAGCGGGTGCGGTTACTGCTGCATCTGGTGGTGTAACGGCCACAACAGGCACGGTGACAATGGCAGGGGCAGTGATTGCGCCG
TCAACAAAGTGCAAACAGAGAGCGAGTGCTAATGAAAACAGTCGGTTCCACCCAGGGTCCATGCCTGTGATCGACGATCGTCCGGCAGAC
GCGGGCTCAGGGGCGGGGCTGCGTGTGAACACTTCTGAAGGGGTTGTGCTCCTGAGTTACTCAGGGCAGAAGACCGAAGGCCCACAGCGG
ATCAGCGCCAAGATCAGCCAGATCCCCCCGGCCAGTGCAATGGACATTGAATTTCAGCAGTCAGTGTCCAAGTCCCAGGTCAAACCTGAT
TCTGTCACAGCATCGCAGCCTCCATCCAAAGGCCCTCAAGCTCCTGCAGGCTATGCGAACGTGGCCACCCATTCCACGTTGGTACTGACC
GCCCAGACATATAATGCCTCTCCTGTGATTTCGTCTGTGAAGGCCGATAGGCCATCCTTGGAGAAGCCCGAGCCCATTCACCTCTCGGTG
TCCACGCCTGTCACCCAGGGAGGCACAGTGAAGGTTCTCACCCAGGGGATCAACACACCCCCTGTGCTGGTTCACAACCAGCTGGTCCTC
ACCCCAAGCATTGTCACCACAAACAAGAAGCTTGCTGACCCCGTCACCCTTAAAATCGAGACCAAGGTCCTTCAGCCGGCCAACCTGGGG
TCCACGCTCACGCCCCACCACCCTCCTGCTCTGCCCAGCAAACTGCCTACAGAAGTCAACCATGTCCCCTCGGGGCCCAGCATCCCAGCA
GATCGAACTGTCTCCCATTTGGCAGCTGCAAAGCTAGATGCTCATTCTCCTCGACCAAGTGGACCCGGGCCATCCTCATTCCCAAGGGCA
AGCCACCCCAGCAGTACTGCATCTACGGCGCTCTCCACCAACGCCACAGTCATGCTGGCTGCAGGCATCCCAGTGCCCCAGTTCATCTCC
AGCATCCACCCAGAGCAGTCTGTCATCATGCCACCCCACAGCATCACCCAGACTGTGTCCCTGAGCCACCTCTCCCAGGGCGAGGTGAGA
ATGAACACTCCCACGCTGCCCAGTATCACCTACAGCATCCGGCCAGAAGCGCTTCACTCTCCTCGGGCTCCGCTGCAGCCCCAGCAAATA
GAGGTCAGGGCCCCACAGCGTGCCAGCACCCCGCAGCCAGCCCCAGCTGGTGTGCCTGCACTGGCCTCCCAGCACCCTCCCGAGGAGGAA
GTGCATTATCACCTTCCTGTCGCTCGAGCCACAGCCCCTGTGCAGTCAGAGGTACTAGTCATGCAGTCTGAGTACCGACTGCACCCCTAT
ACTGTGCCACGGGATGTGAGGATCATGGTGCATCCACATGTGACGGCAGTCAGCGAGCAGCCCAGGGCCGCGGATGGGGTGGTGAAGGTG
CCACCAGCCAGCAAGGCCCCTCAGCAGCCAGGGAAGGAAGCTGCCAAGACACCAGATGCCAAAGCTGCCCCCACCCCCACCCCTGCCCCC
GTCCCTGTCCCTGTCCCCCTTCCTGCCCCTGCTCCTGCCCCTCATGGTGAGGCCCGTATCCTCACAGTTACCCCCAGTAACCAACTCCAG
GGGCTGCCTCTGACCCCTCCTGTGGTGGTGACCCATGGGGTGCAGATTGTGCACTCCAGCGGGGAGCTGTTTCAAGAGTACCGGTACGGC
GACATCCGCACCTACCACCCCCCGGCCCAGCTCACACACACTCAGTTTCCCGCCGCTTCCTCTGTTGGCCTGCCTTCCCGGACCAAGACA
GCTGCTCAGGGCCCTCCTCCTGAAGGTGAGCCCCTGCAGCCTCCTCAGCCTGTGCAGTCCACACAGCCTGCCCAGCCTGCACCACCCTGC
CCGCCCTCCCAGCTCGGTCAGCCCGGCCAGCCACCAAGCAGCAAGATGCCTCAAGTGTCCCAGGAGGCAAAGGGGACCCAGACGGGAGTA
GAGCAGCCTCGCCTCCCAGCTGGACCTGCAAACAGGCCACCTGAGCCTCACACCCAGGTTCAGAGGGCACAAGCAGAAACAGGCCCGACT
TCCTTCCCCTCCCCTGTGTCTGTCTCCATGAAGCCTGACCTTCCAGTCTCTCTTCCCACTCAGACTGCCCCAAAACAGCCGTTGTTTGTC
CCAACAACCTCTGGCCCCAGCACCCCACCAGGACTGGTTCTGCCACACACTGAATTCCAGCCAGCCCCCAAACAAGATTCCTCTCCACAC
CTGACTTCCCAGAGACCCGTGGATATGGTTCAACTTCTGAAGAAGTACCCCATCGTGTGGCAGGGCCTGCTGGCCCTCAAGAATGACACA
GCTGCTGTGCAGCTCCACTTCGTCTCTGGCAACAACGTCCTGGCCCATCGGTCCCTGCCCCTTTCTGAAGGAGGGCCCCCACTAAGGATC
GCCCAGAGGATGCGGCTGGAGGCAACGCAGCTGGAAGGGGTTGCCCGAAGGATGACGGTGGAGACAGATTACTGTCTGCTGCTGGCTCTG
CCCTGTGGCCGTGACCAAGAGGATGTTGTGAGCCAGACCGAGTCCCTCAAGGCTGCCTTCATCACTTACCTGCAGGCCAAGCAGGCGGCA
GGGATCATCAACGTTCCCAACCCTGGCTCCAATCAGCCTGCCTACGTGCTGCAGATCTTCCCGCCCTGTGAGTTCTCTGAGAGTCACCTG
TCCCGCCTGGCCCCTGACCTCCTTGCCAGCATCTCCAACATCTCTCCCCACCTCATGATTGTCATTGCCTCCGTGTGAGCCACTGAGTGG
TTATCACCTCAGTGAATCTTCCCAGGGCTCTGCAGTAAAAACAAAGGACAACCCAGCCAAGCAGAGGAAGAAGCTGCCGAAGGGGACAGA
CTCCACTGCCAGACGGCCAGCCGTTTGCTGTCCTGCCGCCCGGCTCAGTCGGCCAGACTTCCTCTAGGAGTGGTGCTGCTACCTTGTATG
TTTACATAATGCTTTAGCCCAAGGACACATCACCAACCCATGGACTCGCAGACACCGGGGCTGGGTTTCTCTTTCCTCTTTTTGGAGAAA
AGGAACAGGGCAGTGGAATGAAAATTTTTTGTTTGTTTGTTTTTAAGAAACAAGAAAACAGAACTGCCTTTGCACTAAATTAGTGACTTG
GACTTTTGCCCAGTGAAGACAGGCTGTGACACTCTGGATGTCTTGGTGTGTGTAGACACACATTGCAGACTCTTAACGCAGGAAGGACTT
CAAACTTCTGCTGAGACCTTGGGGTCAAGGAACATTTCATTGGTTTTTTTTGTCCACCCCCATCTCCCTTGCTCATTTGGATGCGTCACC
TTAATTCTCCTGCTGCCACCGTCTTTGATTCACCGGGATGTACAGTTTACAGTTGAAGAGCAAACAGAAAGGTTTTCTCTTGGTGGGATA
TGCAGAACTTGGGATGTGTGTATATATAAATATATAATATATATAAATATATATAATACTGACTTAAAAAATCAAATCCCCCGACATACG
TTTTTTTTAATCTGTGCCAAAAATGTGTTTTCAGAGGAAATCTTATTTTCATATTCAGACTTTGTATTGCCCACTCATTTGTATAAGTGC
GCTTCGGTACAGCACGGGTCCTGCTCCCGCGATGTGGAAGTGTCACACGGCACCTGTACAAAAAGACTGGCTAACCCCTCTTCCTATTAC
CTTGATCTCTTCCCCCAACTTCCTAACACTTATTAATTTATGAAACTGTTTTTCTCAGCGCAGTTTTGTTTTGTGTGTCCATTGGATTAC

>86141_86141_1_SPTBN1-SPEN_SPTBN1_chr2_54853321_ENST00000333896_SPEN_chr1_16245519_ENST00000375759_length(amino acids)=3194AA_BP=28
MAERKPASGVSEIFQEMLYIMDWMDEMKEYLGNNRLKLGFGKSMPTNCVWLDGLSSNVSDQYLTRHFCRYGPVVKVVFDRLKGMALVLYN
EIEYAQAAVKETKGRKIGGNKIKVDFANRESQLAFYHCMEKSGQDIRDFYEMLAERREERRASYDYNQDRTYYESVRTPGTYPEDSRRDY
PARGREFYSEWETYQGDYYESRYYDDPREYRDYRNDPYEQDIREYSYRQRERERERERFESDRDRDHERRPIERSQSPVHLRRPQSPGAS
PSQAERLPSDSERRLYSRSSDRSGSCSSLSPPRYEKLDKSRLERYTKNEKTDKERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVHS
PSSQSSETDQENEREQSPEKPRSCNKLSREKADKEGIAKNRLELMPCVVLTRVKEKEGKVIDHTPVEKLKAKLDNDTVKSSALDQKLQVS
QTEPAKSDLSKLESVRMKVPKEKGLSSHVEVVEKEGRLKARKHLKPEQPADGVSAVDLEKLEARKRRFADSNLKAEKQKPEVKKSSPEME
DARVLSKKQPDVSSREVILLREGEAERKPVRKEILKRESKKIKLDRLNTVASPKDCQELASISVGSGSRPSSDLQARLGELAGESVENQE
VQSKKPIPSKPQLKQLQVLDDQGPEREDVRKNYCSLRDETPERKSGQEKSHSVNTEEKIGIDIDHTQSYRKQMEQSRRKQQMEMEIAKSE
KFGSPKKDVDEYERRSLVHEVGKPPQDVTDDSPPSKKKRMDHVDFDICTKRERNYRSSRQISEDSERTGGSPSVRHGSFHEDEDPIGSPR
LLSVKGSPKVDEKVLPYSNITVREESLKFNPYDSSRREQMADMAKIKLSVLNSEDELNRWDSQMKQDAGRFDVSFPNSIIKRDSLRKRSV
RDLEPGEVPSDSDEDGEHKSHSPRASALYESSRLSFLLRDREDKLRERDERLSSSLERNKFYSFALDKTITPDTKALLERAKSLSSSREE
NWSFLDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKKKKIRTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSIFEQDSKRLQHLERKE
EDSDFISGRIYGKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPP
SVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPY
LDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNK
SKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYAT
MGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKG
KNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKS
ASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAK
LAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVS
GILETEAATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESN
QAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRV
HSIIESDPVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSSTLRKILMD
PKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSID
LENSQKITLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVLTGPVNVLTTPVNATVGTVNA
APGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVTMAGAVIAPSTKCKQRASANENSRFHPGSMPVIDDRPADAGSGAGLRVNT
SEGVVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVIS
SVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHPPAL
PSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTALSTNATVMLAAGIPVPQFISSIHPEQSVIMP
PHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARAT
APVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPA
PAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEP
LQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVSVSMK
PDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEFQPAPKQDSSPHLTSQRPVDMVQLLKKYPIVWQGLLALKNDTAAVQLHFVSGN
NVLAHRSLPLSEGGPPLRIAQRMRLEATQLEGVARRMTVETDYCLLLALPCGRDQEDVVSQTESLKAAFITYLQAKQAAGIINVPNPGSN

--------------------------------------------------------------
>86141_86141_2_SPTBN1-SPEN_SPTBN1_chr2_54853321_ENST00000356805_SPEN_chr1_16245519_ENST00000375759_length(transcript)=12206nt_BP=1672nt
GGAATCAGTGCCGCTGTTGCCGTGCAGGCTGCGGATTCCTCCAGTCCCTCCCTCGGCCGCCTCTCCTCCCGGAGCGAGCGCGCAGCCCTG
CGCAGCAGCGCCCACTGGTCCCGTCCTGTGAGCCCCGGCCCCAGCCGCGGACAGACCCGCGGAGTCGCCTCCCGGCCCACCCGCCCGGCC
GCCGAGGAGCGGGAGGAGGACGGGACCCCGGCGCCCCCACCCCATCCCCGGGAGAACTCTAAGAAGGAGCTGATGTGGAGGAGCAGCTGA
GACAGTTCAAGATGACGACCACAGTAGCCACAGACTATGACAACATTGAGATCCAGCAGCAGTACAGTGATGTCAACAACCGCTGGGATG
TCGACGACTGGGACAATGAGAACAGCTCTGCGCGGCTTTTTGAGCGGTCCCGCATCAAGGCTCTGGCAGATGAGCGTGAAGCCGTGCAGA
AGAAGACCTTCACCAAGTGGGTCAATTCCCACCTTGCCCGTGTGTCCTGCCGGATCACAGACCTGTACACTGACCTTCGAGATGGACGGA
TGCTCATCAAGCTGCTGGAGGTCCTCTCTGGAGAGAGGCTGCCTAAACCCACCAAGGGACGAATGCGCATCCACTGCTTAGAGAATGTGG
ACAAGGCCCTTCAGTTCCTGAAGGAGCAGAGAGTCCATCTTGAGAACATGGGGTCCCATGACATCGTGGATGGAAACCACCGGCTGACCC
TTGGCCTCATCTGGACCATCATCCTGCGCTTCCAGATCCAGGATATCAGTGTGGAAACTGAAGACAACAAAGAGAAGAAATCTGCCAAGG
ATGCATTGCTGTTGTGGTGCCAGATGAAGACAGCTGGGTACCCCAATGTCAACATTCACAATTTCACCACTAGCTGGAGGGACGGCATGG
CCTTCAATGCACTGATACACAAACACCGGCCTGACCTGATAGATTTTGACAAACTAAAGAAATCTAACGCACACTACAACCTGCAGAATG
CATTTAATCTGGCAGAACAGCACCTCGGCCTCACTAAACTGTTGGACCCCGAAGACATCAGCGTGGACCATCCTGATGAGAAGTCCATAA
TCACTTATGTGGTGACTTATTACCACTACTTCTCTAAGATGAAGGCCTTAGCTGTTGAAGGAAAACGAATTGGAAAGGTGCTTGACAATG
CTATTGAAACAGAAAAAATGATTGAAAAGTATGAATCACTTGCCTCTGACCTTCTGGAATGGATTGAACAAACCATCATCATTCTGAACA
ATCGCAAATTTGCCAATTCACTGGTCGGGGTTCAACAGCAGCTTCAGGCATTCAACACTTACCGCACTGTGGAGAAACCACCCAAATTTA
CTGAGAAGGGGAACTTGGAAGTGCTGCTCTTCACCATTCAGAGCAAGATGAGGGCCAACAACCAGAAGGTCTACATGCCCCGGGAGGGGA
AGCTCATCTCTGACATCAACAAGGCCTGGGAAAGACTGGAAAAAGCGGAACACGAAAGAGAACTGGCTTTGCGGAATGAGCTCATAAGAC
AGGAGAAACTGGAACAGCTCGCCCGCAGATTTGATCGCAAGGCAGCTATGAGGGAGACTTGGCTGAGCGAAAACCAGCGTCTGGTGTCTC
AGAGATATTCCAGGAAATGCTCTACATTATGGACTGGATGGATGAAATGAAGGAATATCTTGGAAATAATCGCCTCAAGCTGGGTTTTGG
AAAGAGCATGCCTACAAACTGCGTGTGGCTAGATGGGCTTTCTTCGAATGTGTCAGATCAGTATTTAACACGACATTTCTGCCGATATGG
GCCTGTGGTAAAGGTGGTGTTTGACCGCTTAAAAGGCATGGCCCTGGTTCTCTACAATGAAATTGAATATGCACAAGCAGCTGTAAAAGA
GACCAAAGGGAGGAAAATCGGTGGGAATAAAATTAAGGTGGATTTTGCAAATCGGGAAAGTCAGCTGGCTTTTTATCACTGCATGGAGAA
ATCTGGTCAAGACATCAGAGACTTTTATGAAATGTTAGCCGAAAGAAGAGAGGAACGAAGGGCATCCTACGACTATAACCAAGATCGTAC
ATATTATGAGAGTGTTCGAACTCCAGGCACTTATCCTGAGGATTCCAGGCGGGACTATCCAGCTCGAGGGAGAGAGTTTTATTCAGAATG
GGAAACTTACCAAGGAGACTACTATGAATCACGATACTACGATGATCCTCGGGAATACAGGGATTACAGGAATGATCCTTATGAACAAGA
TATTAGGGAATATAGTTACAGGCAAAGGGAACGAGAAAGAGAACGTGAAAGATTTGAGTCTGACCGGGACAGAGACCATGAGAGGAGGCC
GATTGAACGAAGTCAAAGTCCTGTTCACTTGCGACGTCCACAGAGTCCTGGAGCGTCTCCCTCTCAGGCAGAGAGGTTGCCGAGTGATTC
TGAGAGGAGGCTTTACAGCCGATCCTCAGACCGGAGTGGAAGCTGTAGCTCACTCTCCCCTCCAAGATATGAGAAACTGGACAAGTCTCG
TTTGGAGCGCTATACAAAAAATGAAAAGACAGATAAAGAACGAACTTTTGATCCGGAGAGAGTGGAGAGAGAGAGACGCTTAATACGGAA
GGAAAAAGTGGAAAAGGACAAAACTGACAAGCAGAAACGCAAAGGAAAGGTTCACTCCCCTAGTTCTCAGTCTTCAGAAACGGACCAAGA
AAATGAGCGAGAGCAAAGCCCTGAAAAGCCCAGGAGTTGTAATAAACTGAGCAGAGAGAAAGCTGACAAAGAGGGAATAGCGAAAAACCG
CCTGGAACTCATGCCTTGCGTGGTTTTGACTCGAGTGAAAGAGAAAGAGGGAAAGGTCATTGACCACACTCCTGTGGAAAAGTTGAAAGC
CAAGCTTGATAATGACACTGTCAAATCTTCTGCCCTGGACCAGAAACTTCAGGTCTCTCAGACGGAGCCTGCAAAATCTGACTTGTCTAA
ACTGGAATCAGTTAGAATGAAAGTACCAAAGGAAAAGGGGCTTTCAAGCCATGTTGAAGTGGTGGAGAAGGAAGGCAGGCTTAAAGCCAG
GAAGCACCTCAAGCCTGAGCAGCCTGCAGATGGGGTAAGTGCTGTGGATCTGGAGAAGCTGGAAGCCAGGAAAAGGCGCTTTGCAGATTC
CAATTTAAAAGCAGAAAAGCAAAAACCAGAGGTCAAGAAAAGCAGTCCAGAGATGGAGGATGCTCGCGTGCTTTCAAAAAAGCAGCCTGA
CGTGTCCTCTAGAGAGGTCATTCTGCTGAGGGAAGGAGAGGCTGAAAGAAAGCCTGTGAGGAAAGAAATTCTTAAAAGAGAATCTAAAAA
AATCAAACTGGACAGACTTAATACTGTTGCCAGCCCCAAAGACTGTCAGGAGCTTGCCAGTATTTCTGTTGGGTCTGGCTCAAGGCCCAG
CTCAGACCTACAAGCAAGACTGGGAGAACTAGCAGGTGAATCTGTGGAAAATCAAGAAGTCCAATCAAAAAAGCCCATTCCCTCAAAACC
ACAGCTCAAACAGCTGCAGGTATTAGATGATCAAGGACCAGAGAGAGAAGACGTTAGGAAAAACTATTGCAGTCTTCGTGATGAAACACC
TGAACGTAAATCAGGCCAAGAGAAATCACATTCAGTAAATACTGAAGAAAAAATTGGCATTGACATCGATCACACGCAGAGTTACCGAAA
ACAAATGGAACAGAGTCGTAGGAAACAGCAGATGGAAATGGAAATAGCCAAGTCTGAGAAGTTTGGCAGTCCTAAAAAAGATGTAGATGA
ATATGAAAGACGTAGCCTCGTTCACGAGGTAGGCAAACCCCCTCAAGATGTCACTGATGACTCTCCTCCTAGCAAAAAGAAAAGGATGGA
TCATGTCGATTTTGATATCTGCACCAAGCGAGAACGGAATTACAGAAGTTCACGCCAAATCAGCGAAGATTCTGAAAGGACTGGTGGTTC
TCCCAGTGTCCGACATGGTTCCTTCCATGAAGATGAGGATCCCATAGGCTCCCCTAGGCTACTGTCAGTAAAAGGGTCTCCTAAAGTAGA
TGAAAAAGTCCTCCCCTATTCTAACATAACAGTCAGGGAAGAGTCTTTAAAATTTAATCCTTATGATTCTAGCAGGAGAGAACAGATGGC
AGATATGGCCAAAATAAAACTATCTGTCTTGAATTCTGAAGATGAACTAAATCGTTGGGACTCTCAGATGAAACAGGATGCTGGCAGATT
TGATGTGAGTTTCCCAAACAGCATAATTAAGAGAGATAGCCTTCGAAAAAGGTCTGTACGAGATCTGGAACCTGGTGAGGTGCCTTCTGA
TTCTGACGAAGATGGTGAACACAAATCCCACTCACCCAGAGCCTCTGCATTATATGAAAGTTCTCGATTGTCTTTTTTATTGAGGGACAG
AGAAGACAAGCTACGTGAGCGAGATGAAAGACTCTCTAGTTCTTTAGAAAGGAACAAATTTTACTCTTTTGCATTGGATAAGACAATCAC
ACCAGACACTAAAGCTTTGCTTGAAAGAGCTAAATCCCTCTCTTCATCTCGTGAAGAAAATTGGTCTTTTCTTGATTGGGACTCCCGATT
TGCAAATTTTCGAAACAACAAAGATAAAGAAAAGGTTGACTCTGCTCCAAGACCTATTCCATCCTGGTACATGAAAAAGAAGAAAATTAG
GACTGATTCAGAAGGGAAAATGGATGATAAGAAAGAGGACCATAAAGAAGAAGAGCAAGAGAGGCAGGAATTGTTTGCTTCTCGTTTTTT
ACACAGCTCAATCTTTGAACAAGATTCCAAGCGATTGCAGCATCTAGAGAGAAAAGAGGAAGATTCTGACTTCATTTCTGGTAGGATCTA
TGGGAAGCAGACATCTGAGGGAGCAAACAGCACAACTGATTCCATTCAAGAACCAGTAGTTCTGTTCCATAGCAGATTTATGGAGCTCAC
ACGGATGCAACAGAAAGAAAAAGAAAAAGACCAGAAACCCAAAGAGGTTGAGAAACAGGAAGATACAGAGAATCATCCCAAGACCCCAGA
ATCTGCTCCTGAGAATAAAGATTCAGAACTGAAAACTCCACCTTCCGTTGGGCCTCCAAGTGTCACAGTCGTAACTCTAGAATCAGCCCC
ATCAGCACTAGAGAAGACCACTGGTGACAAAACGGTAGAGGCGCCTTTGGTAACAGAAGAGAAGACTGTGGAGCCAGCTACCGTCTCAGA
AGAAGCAAAGCCTGCATCTGAACCTGCTCCTGCCCCTGTGGAACAGCTGGAACAAGTAGACCTGCCCCCAGGAGCAGACCCCGATAAAGA
AGCTGCCATGATGCCTGCGGGTGTTGAGGAAGGTTCATCAGGTGACCAGCCGCCTTATCTGGATGCCAAGCCTCCAACTCCCGGGGCCTC
GTTTTCCCAGGCAGAGAGCAACGTAGATCCAGAGCCTGACAGTACCCAGCCACTTTCAAAACCAGCTCAGAAGTCTGAGGAAGCCAATGA
GCCAAAGGCCGAAAAGCCAGACGCCACTGCAGATGCTGAGCCTGATGCAAACCAGAAAGCCGAAGCTGCTCCTGAGTCTCAGCCCCCAGC
TTCTGAAGATTTAGAGGTTGATCCTCCAGTTGCTGCAAAGGATAAAAAGCCAAACAAAAGCAAGCGTTCAAAGACCCCTGTTCAGGCAGC
TGCAGTGAGTATCGTGGAGAAGCCCGTCACAAGGAAGAGTGAGAGGATAGACCGGGAAAAACTCAAGCGGTCCAATTCTCCTCGGGGAGA
AGCACAGAAGCTTTTGGAATTGAAGATGGAGGCAGAGAAGATTACAAGGACTGCTTCTAAAAACTCTGCTGCAGACCTTGAACATCCCGA
ACCAAGTTTGCCTCTCAGCCGAACAAGGCGCCGGAATGTAAGGAGCGTCTATGCAACCATGGGTGACCATGAAAACCGCTCTCCTGTCAA
AGAGCCCGTTGAGCAACCAAGAGTGACCAGAAAGAGATTGGAGCGAGAGCTTCAGGAGGCTGCAGCGGTTCCCACCACCCCTCGGAGGGG
AAGGCCTCCAAAGACACGCCGGCGAGCCGATGAAGAGGAGGAGAACGAGGCCAAGGAACCTGCAGAAACACTCAAGCCACCTGAGGGATG
GCGGTCGCCAAGGTCCCAGAAAACTGCAGCTGGTGGTGGACCCCAAGGGAAAAAGGGAAAAAATGAACCGAAGGTGGATGCTACACGTCC
TGAGGCCACCACTGAGGTGGGCCCCCAAATAGGCGTGAAAGAGAGCTCCATGGAACCCAAGGCTGCTGAGGAGGAGGCAGGGAGTGAACA
GAAACGTGACAGAAAAGATGCTGGCACAGACAAAAACCCCCCTGAAACCGCCCCTGTTGAAGTTGTAGAGAAAAAACCGGCCCCTGAAAA
AAACTCCAAATCAAAGAGAGGAAGATCTCGAAACTCCAGGTTAGCAGTGGACAAATCTGCAAGTCTGAAAAATGTGGATGCTGCTGTCAG
TCCCAGGGGGGCTGCAGCACAGGCAGGGGAGAGGGAATCTGGGGTGGTGGCAGTCTCCCCTGAGAAAAGTGAGAGTCCCCAAAAGGAGGA
TGGTTTATCATCCCAGTTGAAAAGTGATCCAGTTGATCCAGACAAGGAACCAGAGAAAGAAGACGTGTCTGCCTCTGGGCCGTCCCCAGA
AGCCACCCAGTTAGCCAAGCAGATGGAGCTGGAGCAGGCCGTGGAACACATCGCAAAGCTCGCTGAGGCCTCTGCCTCTGCTGCCTATAA
GGCAGATGCACCAGAGGGCCTTGCCCCAGAGGACAGGGACAAGCCTGCACACCAAGCAAGTGAAACAGAGCTGGCTGCGGCCATCGGCTC
CATCATCAATGACATTTCTGGGGAGCCAGAAAACTTCCCAGCACCTCCACCTTATCCTGGAGAATCCCAGACAGATCTGCAACCCCCCGC
AGGTGCACAGGCGCTGCAGCCTTCTGAGGAAGGAATGGAGACAGATGAGGCTGTATCTGGCATCCTGGAAACTGAGGCTGCTACAGAATC
TTCTAGGCCTCCAGTCAATGCTCCTGACCCCTCAGCCGGCCCAACAGATACCAAGGAAGCCAGAGGAAATAGCAGTGAAACCTCACACTC
AGTGCCAGAAGCCAAAGGGTCTAAAGAAGTGGAAGTCACTCTTGTTCGGAAAGACAAAGGGCGCCAGAAAACAACCCGATCACGCCGCAA
GCGAAACACAAACAAGAAAGTGGTGGCTCCTGTAGAGAGCCATGTCCCTGAATCCAACCAAGCTCAAGGTGAGAGTCCTGCTGCAAATGA
GGGGACAACAGTACAGCACCCCGAAGCCCCACAGGAAGAAAAGCAGAGTGAGAAACCCCATTCCACTCCTCCTCAGTCATGTACTTCTGA
CCTAAGCAAGATTCCCTCCACAGAGAATTCGTCCCAAGAAATCAGTGTTGAGGAAAGGACTCCAACCAAAGCATCTGTGCCCCCAGACCT
TCCCCCACCTCCCCAGCCAGCACCGGTGGATGAGGAGCCTCAAGCCAGGTTCAGGGTGCATTCCATCATTGAAAGTGACCCGGTGACCCC
ACCCAGCGATCCAAGCATCCCCATACCCACACTGCCTTCTGTAACTGCAGCAAAGCTCTCACCTCCTGTCGCCTCTGGGGGGATCCCACA
CCAGAGCCCCCCTACTAAGGTGACAGAGTGGATCACAAGGCAGGAGGAGCCACGGGCTCAGTCTACTCCATCTCCAGCTCTTCCCCCAGA
CACAAAGGCCTCTGATGTTGACACCAGCTCCAGCACCCTGAGGAAGATTCTCATGGACCCCAAGTATGTGTCTGCCACAAGTGTCACTTC
CACAAGTGTCACCACAGCCATTGCAGAGCCTGTCAGTGCTGCCCCTTGCCTACATGAGGCCCCGCCCCCGCCAGTTGACTCTAAAAAGCC
TTTAGAAGAAAAAACAGCACCTCCAGTGACAAACAACTCTGAGATACAAGCCTCGGAGGTGCTGGTAGCTGCTGACAAGGAAAAGGTGGC
TCCAGTCATTGCTCCCAAAATTACCTCTGTTATTAGCCGGATGCCTGTCAGCATTGACCTGGAAAATTCACAGAAGATAACCTTGGCAAA
ACCAGCTCCTCAAACCCTCACTGGTCTGGTGAGCGCACTCACTGGCCTGGTGAACGTCTCCCTGGTCCCGGTGAATGCCCTGAAAGGCCC
CGTGAAGGGCTCAGTGACCACACTGAAAAGTTTGGTGAGCACCCCTGCTGGGCCCGTGAACGTCCTGAAAGGGCCTGTGAATGTTCTTAC
GGGGCCAGTGAATGTTCTCACCACTCCAGTGAACGCCACGGTGGGCACAGTGAATGCCGCCCCAGGCACAGTCAATGCCGCTGCGAGTGC
AGTGAATGCCACAGCAAGTGCAGTGACCGTCACAGCGGGTGCGGTTACTGCTGCATCTGGTGGTGTAACGGCCACAACAGGCACGGTGAC
AATGGCAGGGGCAGTGATTGCGCCGTCAACAAAGTGCAAACAGAGAGCGAGTGCTAATGAAAACAGTCGGTTCCACCCAGGGTCCATGCC
TGTGATCGACGATCGTCCGGCAGACGCGGGCTCAGGGGCGGGGCTGCGTGTGAACACTTCTGAAGGGGTTGTGCTCCTGAGTTACTCAGG
GCAGAAGACCGAAGGCCCACAGCGGATCAGCGCCAAGATCAGCCAGATCCCCCCGGCCAGTGCAATGGACATTGAATTTCAGCAGTCAGT
GTCCAAGTCCCAGGTCAAACCTGATTCTGTCACAGCATCGCAGCCTCCATCCAAAGGCCCTCAAGCTCCTGCAGGCTATGCGAACGTGGC
CACCCATTCCACGTTGGTACTGACCGCCCAGACATATAATGCCTCTCCTGTGATTTCGTCTGTGAAGGCCGATAGGCCATCCTTGGAGAA
GCCCGAGCCCATTCACCTCTCGGTGTCCACGCCTGTCACCCAGGGAGGCACAGTGAAGGTTCTCACCCAGGGGATCAACACACCCCCTGT
GCTGGTTCACAACCAGCTGGTCCTCACCCCAAGCATTGTCACCACAAACAAGAAGCTTGCTGACCCCGTCACCCTTAAAATCGAGACCAA
GGTCCTTCAGCCGGCCAACCTGGGGTCCACGCTCACGCCCCACCACCCTCCTGCTCTGCCCAGCAAACTGCCTACAGAAGTCAACCATGT
CCCCTCGGGGCCCAGCATCCCAGCAGATCGAACTGTCTCCCATTTGGCAGCTGCAAAGCTAGATGCTCATTCTCCTCGACCAAGTGGACC
CGGGCCATCCTCATTCCCAAGGGCAAGCCACCCCAGCAGTACTGCATCTACGGCGCTCTCCACCAACGCCACAGTCATGCTGGCTGCAGG
CATCCCAGTGCCCCAGTTCATCTCCAGCATCCACCCAGAGCAGTCTGTCATCATGCCACCCCACAGCATCACCCAGACTGTGTCCCTGAG
CCACCTCTCCCAGGGCGAGGTGAGAATGAACACTCCCACGCTGCCCAGTATCACCTACAGCATCCGGCCAGAAGCGCTTCACTCTCCTCG
GGCTCCGCTGCAGCCCCAGCAAATAGAGGTCAGGGCCCCACAGCGTGCCAGCACCCCGCAGCCAGCCCCAGCTGGTGTGCCTGCACTGGC
CTCCCAGCACCCTCCCGAGGAGGAAGTGCATTATCACCTTCCTGTCGCTCGAGCCACAGCCCCTGTGCAGTCAGAGGTACTAGTCATGCA
GTCTGAGTACCGACTGCACCCCTATACTGTGCCACGGGATGTGAGGATCATGGTGCATCCACATGTGACGGCAGTCAGCGAGCAGCCCAG
GGCCGCGGATGGGGTGGTGAAGGTGCCACCAGCCAGCAAGGCCCCTCAGCAGCCAGGGAAGGAAGCTGCCAAGACACCAGATGCCAAAGC
TGCCCCCACCCCCACCCCTGCCCCCGTCCCTGTCCCTGTCCCCCTTCCTGCCCCTGCTCCTGCCCCTCATGGTGAGGCCCGTATCCTCAC
AGTTACCCCCAGTAACCAACTCCAGGGGCTGCCTCTGACCCCTCCTGTGGTGGTGACCCATGGGGTGCAGATTGTGCACTCCAGCGGGGA
GCTGTTTCAAGAGTACCGGTACGGCGACATCCGCACCTACCACCCCCCGGCCCAGCTCACACACACTCAGTTTCCCGCCGCTTCCTCTGT
TGGCCTGCCTTCCCGGACCAAGACAGCTGCTCAGGGCCCTCCTCCTGAAGGTGAGCCCCTGCAGCCTCCTCAGCCTGTGCAGTCCACACA
GCCTGCCCAGCCTGCACCACCCTGCCCGCCCTCCCAGCTCGGTCAGCCCGGCCAGCCACCAAGCAGCAAGATGCCTCAAGTGTCCCAGGA
GGCAAAGGGGACCCAGACGGGAGTAGAGCAGCCTCGCCTCCCAGCTGGACCTGCAAACAGGCCACCTGAGCCTCACACCCAGGTTCAGAG
GGCACAAGCAGAAACAGGCCCGACTTCCTTCCCCTCCCCTGTGTCTGTCTCCATGAAGCCTGACCTTCCAGTCTCTCTTCCCACTCAGAC
TGCCCCAAAACAGCCGTTGTTTGTCCCAACAACCTCTGGCCCCAGCACCCCACCAGGACTGGTTCTGCCACACACTGAATTCCAGCCAGC
CCCCAAACAAGATTCCTCTCCACACCTGACTTCCCAGAGACCCGTGGATATGGTTCAACTTCTGAAGAAGTACCCCATCGTGTGGCAGGG
CCTGCTGGCCCTCAAGAATGACACAGCTGCTGTGCAGCTCCACTTCGTCTCTGGCAACAACGTCCTGGCCCATCGGTCCCTGCCCCTTTC
TGAAGGAGGGCCCCCACTAAGGATCGCCCAGAGGATGCGGCTGGAGGCAACGCAGCTGGAAGGGGTTGCCCGAAGGATGACGGTGGAGAC
AGATTACTGTCTGCTGCTGGCTCTGCCCTGTGGCCGTGACCAAGAGGATGTTGTGAGCCAGACCGAGTCCCTCAAGGCTGCCTTCATCAC
TTACCTGCAGGCCAAGCAGGCGGCAGGGATCATCAACGTTCCCAACCCTGGCTCCAATCAGCCTGCCTACGTGCTGCAGATCTTCCCGCC
CTGTGAGTTCTCTGAGAGTCACCTGTCCCGCCTGGCCCCTGACCTCCTTGCCAGCATCTCCAACATCTCTCCCCACCTCATGATTGTCAT
TGCCTCCGTGTGAGCCACTGAGTGGTTATCACCTCAGTGAATCTTCCCAGGGCTCTGCAGTAAAAACAAAGGACAACCCAGCCAAGCAGA
GGAAGAAGCTGCCGAAGGGGACAGACTCCACTGCCAGACGGCCAGCCGTTTGCTGTCCTGCCGCCCGGCTCAGTCGGCCAGACTTCCTCT
AGGAGTGGTGCTGCTACCTTGTATGTTTACATAATGCTTTAGCCCAAGGACACATCACCAACCCATGGACTCGCAGACACCGGGGCTGGG
TTTCTCTTTCCTCTTTTTGGAGAAAAGGAACAGGGCAGTGGAATGAAAATTTTTTGTTTGTTTGTTTTTAAGAAACAAGAAAACAGAACT
GCCTTTGCACTAAATTAGTGACTTGGACTTTTGCCCAGTGAAGACAGGCTGTGACACTCTGGATGTCTTGGTGTGTGTAGACACACATTG
CAGACTCTTAACGCAGGAAGGACTTCAAACTTCTGCTGAGACCTTGGGGTCAAGGAACATTTCATTGGTTTTTTTTGTCCACCCCCATCT
CCCTTGCTCATTTGGATGCGTCACCTTAATTCTCCTGCTGCCACCGTCTTTGATTCACCGGGATGTACAGTTTACAGTTGAAGAGCAAAC
AGAAAGGTTTTCTCTTGGTGGGATATGCAGAACTTGGGATGTGTGTATATATAAATATATAATATATATAAATATATATAATACTGACTT
AAAAAATCAAATCCCCCGACATACGTTTTTTTTAATCTGTGCCAAAAATGTGTTTTCAGAGGAAATCTTATTTTCATATTCAGACTTTGT
ATTGCCCACTCATTTGTATAAGTGCGCTTCGGTACAGCACGGGTCCTGCTCCCGCGATGTGGAAGTGTCACACGGCACCTGTACAAAAAG
ACTGGCTAACCCCTCTTCCTATTACCTTGATCTCTTCCCCCAACTTCCTAACACTTATTAATTTATGAAACTGTTTTTCTCAGCGCAGTT

>86141_86141_2_SPTBN1-SPEN_SPTBN1_chr2_54853321_ENST00000356805_SPEN_chr1_16245519_ENST00000375759_length(amino acids)=3194AA_BP=28
MAERKPASGVSEIFQEMLYIMDWMDEMKEYLGNNRLKLGFGKSMPTNCVWLDGLSSNVSDQYLTRHFCRYGPVVKVVFDRLKGMALVLYN
EIEYAQAAVKETKGRKIGGNKIKVDFANRESQLAFYHCMEKSGQDIRDFYEMLAERREERRASYDYNQDRTYYESVRTPGTYPEDSRRDY
PARGREFYSEWETYQGDYYESRYYDDPREYRDYRNDPYEQDIREYSYRQRERERERERFESDRDRDHERRPIERSQSPVHLRRPQSPGAS
PSQAERLPSDSERRLYSRSSDRSGSCSSLSPPRYEKLDKSRLERYTKNEKTDKERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVHS
PSSQSSETDQENEREQSPEKPRSCNKLSREKADKEGIAKNRLELMPCVVLTRVKEKEGKVIDHTPVEKLKAKLDNDTVKSSALDQKLQVS
QTEPAKSDLSKLESVRMKVPKEKGLSSHVEVVEKEGRLKARKHLKPEQPADGVSAVDLEKLEARKRRFADSNLKAEKQKPEVKKSSPEME
DARVLSKKQPDVSSREVILLREGEAERKPVRKEILKRESKKIKLDRLNTVASPKDCQELASISVGSGSRPSSDLQARLGELAGESVENQE
VQSKKPIPSKPQLKQLQVLDDQGPEREDVRKNYCSLRDETPERKSGQEKSHSVNTEEKIGIDIDHTQSYRKQMEQSRRKQQMEMEIAKSE
KFGSPKKDVDEYERRSLVHEVGKPPQDVTDDSPPSKKKRMDHVDFDICTKRERNYRSSRQISEDSERTGGSPSVRHGSFHEDEDPIGSPR
LLSVKGSPKVDEKVLPYSNITVREESLKFNPYDSSRREQMADMAKIKLSVLNSEDELNRWDSQMKQDAGRFDVSFPNSIIKRDSLRKRSV
RDLEPGEVPSDSDEDGEHKSHSPRASALYESSRLSFLLRDREDKLRERDERLSSSLERNKFYSFALDKTITPDTKALLERAKSLSSSREE
NWSFLDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKKKKIRTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSIFEQDSKRLQHLERKE
EDSDFISGRIYGKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPP
SVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPY
LDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNK
SKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYAT
MGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKG
KNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKS
ASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAK
LAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVS
GILETEAATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESN
QAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRV
HSIIESDPVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSSTLRKILMD
PKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSID
LENSQKITLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVLTGPVNVLTTPVNATVGTVNA
APGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVTMAGAVIAPSTKCKQRASANENSRFHPGSMPVIDDRPADAGSGAGLRVNT
SEGVVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVIS
SVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHPPAL
PSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTALSTNATVMLAAGIPVPQFISSIHPEQSVIMP
PHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARAT
APVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPA
PAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEP
LQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVSVSMK
PDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEFQPAPKQDSSPHLTSQRPVDMVQLLKKYPIVWQGLLALKNDTAAVQLHFVSGN
NVLAHRSLPLSEGGPPLRIAQRMRLEATQLEGVARRMTVETDYCLLLALPCGRDQEDVVSQTESLKAAFITYLQAKQAAGIINVPNPGSN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SPTBN1-SPEN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneSPENchr2:54853321chr1:16245519ENST000003757590152130_246403665.0MSX2
TgeneSPENchr2:54853321chr1:16245519ENST000003757590152709_287003665.0RBPSUH


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000333896-1311563_209302156.0ANK2
HgeneSPTBN1chr2:54853321chr1:16245519ENST00000356805-1361563_209302365.0ANK2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SPTBN1-SPEN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SPTBN1-SPEN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSPTBN1C0043094Weight Gain1CTD_human
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human