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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:VIM-DES (FusionGDB2 ID:HG7431TG1674)

Fusion Gene Summary for VIM-DES

check button Fusion gene summary
Fusion gene informationFusion gene name: VIM-DES
Fusion gene ID: hg7431tg1674
HgeneTgene
Gene symbol

VIM

DES

Gene ID

7431

1674

Gene namevimentindesmin
Synonyms-CDCD3|CMD1F|CSM1|CSM2|LGMD1D|LGMD1E|LGMD2R
Cytomap('VIM')('DES')

10p13

2q35

Type of geneprotein-codingprotein-coding
Descriptionvimentinepididymis secretory sperm binding proteindesmincardiomyopathy, dilated 1F (autosomal dominant)epididymis secretory sperm binding proteinintermediate filament proteinmutant desmin p.K241E
Modification date2020032720200329
UniProtAcc.

P17661

Ensembl transtripts involved in fusion geneENST00000485947, ENST00000224237, 
ENST00000544301, 		ENST00000485947, 
ENST00000224237, ENST00000544301, 
Fusion gene scores* DoF score38 X 18 X 13=88926 X 8 X 5=240
# samples 429
** MAII scorelog2(42/8892*10)=-4.40404671536087
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/240*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VIM [Title/Abstract] AND DES [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointVIM(17275681)-DES(220285217), # samples:1
VIM(17271757)-DES(220283497), # samples:1
Anticipated loss of major functional domain due to fusion event.DES-VIM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DES-VIM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
VIM-DES seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
VIM-DES seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
VIM-DES seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
VIM-DES seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
VIM-DES seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
VIM-DES seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across VIM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across DES (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0644-01AVIMchr10

17275681

+DESchr2

220285217

+
ChimerDB4KICHTCGA-KN-8427-01AVIMchr10

17271757

+DESchr2

220283497

+


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Fusion Gene ORF analysis for VIM-DES

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000485947ENST00000373960VIMchr10

17271757

+DESchr2

220283497

+
Frame-shiftENST00000224237ENST00000373960VIMchr10

17271757

+DESchr2

220283497

+
Frame-shiftENST00000544301ENST00000373960VIMchr10

17271757

+DESchr2

220283497

+
In-frameENST00000224237ENST00000373960VIMchr10

17275681

+DESchr2

220285217

+
In-frameENST00000544301ENST00000373960VIMchr10

17275681

+DESchr2

220285217

+
intron-3CDSENST00000485947ENST00000373960VIMchr10

17275681

+DESchr2

220285217

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000544301VIMchr1017275681+ENST00000373960DESchr2220285217+256011334131810465
ENST00000224237VIMchr1017275681+ENST00000373960DESchr2220285217+22928651451542465

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000544301ENST00000373960VIMchr1017275681+DESchr2220285217+0.0087852060.99121475
ENST00000224237ENST00000373960VIMchr1017275681+DESchr2220285217+0.0085480840.99145186

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Fusion Genomic Features for VIM-DES


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
VIMchr1017275681+DESchr2220285216+0.9994810.000518976
VIMchr1017275681+DESchr2220285216+0.9994810.000518976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for VIM-DES


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:17275681/chr2:220285217)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DES

P17661

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVIMchr10:17275681chr2:220285217ENST00000224237+3996_131240467.0Coiled coilOntology_term=ECO:0000269
HgeneVIMchr10:17275681chr2:220285217ENST00000544301+41096_131240467.0Coiled coilOntology_term=ECO:0000269
HgeneVIMchr10:17275681chr2:220285217ENST00000224237+39132_153240467.0RegionNote=Linker 1
HgeneVIMchr10:17275681chr2:220285217ENST00000224237+392_95240467.0RegionNote=Head
HgeneVIMchr10:17275681chr2:220285217ENST00000544301+410132_153240467.0RegionNote=Linker 1
HgeneVIMchr10:17275681chr2:220285217ENST00000544301+4102_95240467.0RegionNote=Head
TgeneDESchr10:17275681chr2:220285217ENST0000037396029253_268245471.0RegionNote=Linker 12
TgeneDESchr10:17275681chr2:220285217ENST0000037396029269_287245471.0RegionNote=Coil 2A
TgeneDESchr10:17275681chr2:220285217ENST0000037396029288_295245471.0RegionNote=Linker 2
TgeneDESchr10:17275681chr2:220285217ENST0000037396029296_412245471.0RegionNote=Coil 2B
TgeneDESchr10:17275681chr2:220285217ENST0000037396029413_470245471.0RegionNote=Tail

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVIMchr10:17275681chr2:220285217ENST00000224237+39154_245240467.0Coiled coilOntology_term=ECO:0000269
HgeneVIMchr10:17275681chr2:220285217ENST00000224237+39303_407240467.0Coiled coilOntology_term=ECO:0000269
HgeneVIMchr10:17275681chr2:220285217ENST00000544301+410154_245240467.0Coiled coilOntology_term=ECO:0000269
HgeneVIMchr10:17275681chr2:220285217ENST00000544301+410303_407240467.0Coiled coilOntology_term=ECO:0000269
HgeneVIMchr10:17275681chr2:220285217ENST00000224237+39103_411240467.0DomainIF rod
HgeneVIMchr10:17275681chr2:220285217ENST00000544301+410103_411240467.0DomainIF rod
HgeneVIMchr10:17275681chr2:220285217ENST00000224237+39326_329240467.0Motif[IL]-x-C-x-x-[DE] motif
HgeneVIMchr10:17275681chr2:220285217ENST00000544301+410326_329240467.0Motif[IL]-x-C-x-x-[DE] motif
HgeneVIMchr10:17275681chr2:220285217ENST00000224237+39246_268240467.0RegionNote=Linker 12
HgeneVIMchr10:17275681chr2:220285217ENST00000224237+39269_407240467.0RegionNote=Coil 2
HgeneVIMchr10:17275681chr2:220285217ENST00000224237+39408_466240467.0RegionNote=Tail
HgeneVIMchr10:17275681chr2:220285217ENST00000544301+410246_268240467.0RegionNote=Linker 12
HgeneVIMchr10:17275681chr2:220285217ENST00000544301+410269_407240467.0RegionNote=Coil 2
HgeneVIMchr10:17275681chr2:220285217ENST00000544301+410408_466240467.0RegionNote=Tail
TgeneDESchr10:17275681chr2:220285217ENST0000037396029108_416245471.0DomainIF rod
TgeneDESchr10:17275681chr2:220285217ENST0000037396029109_141245471.0RegionNote=Coil 1A
TgeneDESchr10:17275681chr2:220285217ENST0000037396029142_151245471.0RegionNote=Linker 1
TgeneDESchr10:17275681chr2:220285217ENST0000037396029152_252245471.0RegionNote=Coil 1B
TgeneDESchr10:17275681chr2:220285217ENST00000373960292_108245471.0RegionNote=Head


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Fusion Gene Sequence for VIM-DES


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>98108_98108_1_VIM-DES_VIM_chr10_17275681_ENST00000224237_DES_chr2_220285217_ENST00000373960_length(transcript)=2292nt_BP=865nt
CTCTGCCACTCTCGCTCCGAGGTCCCCGCGCCAGAGACGCAGCCGCGCTCCCACCACCCACACCCACCGCGCCCTCGTTCGCCTCTTCTC
CGGGAGCCAGTCCGCGCCACCGCCGCCGCCCAGGCCATCGCCACCCTCCGCAGCCATGTCCACCAGGTCCGTGTCCTCGTCCTCCTACCG
CAGGATGTTCGGCGGCCCGGGCACCGCGAGCCGGCCGAGCTCCAGCCGGAGCTACGTGACTACGTCCACCCGCACCTACAGCCTGGGCAG
CGCGCTGCGCCCCAGCACCAGCCGCAGCCTCTACGCCTCGTCCCCGGGCGGCGTGTATGCCACGCGCTCCTCTGCCGTGCGCCTGCGGAG
CAGCGTGCCCGGGGTGCGGCTCCTGCAGGACTCGGTGGACTTCTCGCTGGCCGACGCCATCAACACCGAGTTCAAGAACACCCGCACCAA
CGAGAAGGTGGAGCTGCAGGAGCTGAATGACCGCTTCGCCAACTACATCGACAAGGTGCGCTTCCTGGAGCAGCAGAATAAGATCCTGCT
GGCCGAGCTCGAGCAGCTCAAGGGCCAAGGCAAGTCGCGCCTGGGGGACCTCTACGAGGAGGAGATGCGGGAGCTGCGCCGGCAGGTGGA
CCAGCTAACCAACGACAAAGCCCGCGTCGAGGTGGAGCGCGACAACCTGGCCGAGGACATCATGCGCCTCCGGGAGAAATTGCAGGAGGA
GATGCTTCAGAGAGAGGAAGCCGAAAACACCCTGCAATCTTTCAGACAGGATGTTGACAATGCGTCTCTGGCACGTCTTGACCTTGAACG
CAAAGTGGAATCTTTGCAAGAAGAGATTGCCTTTTTGAAGAAACTCCACGAAGAGGAGATCCGTGAGTTGCAGGCTCAGCTTCAGGAACA
GCAGGTCCAGGTGGAGATGGACATGTCTAAGCCAGACCTCACTGCCGCCCTCAGGGACATCCGGGCTCAGTATGAGACCATCGCGGCTAA
GAACATTTCTGAAGCTGAGGAGTGGTACAAGTCGAAGGTGTCAGACCTGACCCAGGCAGCCAACAAGAACAACGACGCCCTGCGCCAGGC
CAAGCAGGAGATGATGGAATACCGACACCAGATCCAGTCCTACACCTGCGAGATTGACGCCCTGAAGGGCACTAACGATTCCCTGATGAG
GCAGATGCGGGAATTGGAGGACCGATTTGCCAGTGAGGCCAGTGGCTACCAGGACAACATTGCGCGCCTGGAGGAGGAAATCCGGCACCT
CAAGGATGAGATGGCCCGCCATCTGCGCGAGTACCAGGACCTGCTCAACGTGAAGATGGCCCTGGATGTGGAGATTGCCACCTACCGGAA
GCTGCTGGAGGGAGAGGAGAGCCGGATCAATCTCCCCATCCAGACCTACTCTGCCCTCAACTTCCGAGAAACCAGCCCTGAGCAAAGGGG
TTCTGAGGTCCATACCAAGAAGACGGTGATGATCAAGACCATCGAGACACGGGATGGGGAGGTCGTCAGTGAGGCCACACAGCAGCAGCA
TGAAGTGCTCTAAAGACAGAGACCCTCTGCCACCAGAGACCGTCCTCACCCCTGTCCTCACTGCTCCCTGAAGCCAGCCTTCTTCCATCC
CAGGACACCACACCCAGCCTCAGTCCTCCCCTCACAGCCTCTGACCCCTCCTCACTGGCCATCCCTCGTGGTCCCCAACAGCGACATAGC
CCATCCCTGCCTGGTCACAGGGCATGCCCCGGCCACCTCTGCGGACCCCAGCTGTGAGCCTTGGCTGTTGGCAGTGAGTGAGCCTGGCTC
TTGTGCTGGATGGAGCCCAGGCGGGAGCGGTGGCCCTGTCCCTCCCACCTCTGTGACCTCAGGCACTAGCCTTTGGCTCTGGAGACAGCC
CCAGAGCAGGGTGTTGGGATACTGCAGGGCCAGGACTGAGCCCCGCAGACCTCCCCAGCCCCTAGCCCAGGAGAGAGAAAGCCAGGCAGG
TAGCCAGGGGGACTAGCCCCTGTGGAGACTGGGGGGCTTGAAATTGTCCCCGTGGTCTCTTACTTTCCTTTCCCCAGCCCAGGGTGGACT
TAGAAAGCAGGGGCTACAAGAGGGAATCCCCGAAGGTGCTGGAGGTGGGAGCAGGAGATTGAGAAGGAGAGAAAGTGGGTGAGATGCTGG
AGAAGAGAGGAGAGGAGAGAGGCAGAGAGCGGTCTCAGGCTGGTGGGAGGGGCGCCCACCTCCCCACGCCCTCCCCTCCCCTGCTGCAGG

>98108_98108_1_VIM-DES_VIM_chr10_17275681_ENST00000224237_DES_chr2_220285217_ENST00000373960_length(amino acids)=465AA_BP=84
MSTRSVSSSSYRRMFGGPGTASRPSSSRSYVTTSTRTYSLGSALRPSTSRSLYASSPGGVYATRSSAVRLRSSVPGVRLLQDSVDFSLAD
AINTEFKNTRTNEKVELQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAE
DIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHEEEIRELQAQLQEQQVQVEMDMSKPDLTAALR
DIRAQYETIAAKNISEAEEWYKSKVSDLTQAANKNNDALRQAKQEMMEYRHQIQSYTCEIDALKGTNDSLMRQMRELEDRFASEASGYQD
NIARLEEEIRHLKDEMARHLREYQDLLNVKMALDVEIATYRKLLEGEESRINLPIQTYSALNFRETSPEQRGSEVHTKKTVMIKTIETRD

--------------------------------------------------------------
>98108_98108_2_VIM-DES_VIM_chr10_17275681_ENST00000544301_DES_chr2_220285217_ENST00000373960_length(transcript)=2560nt_BP=1133nt
GCCTCTCCAAAGGCTGCAGAAGTTTCTTGCTAACAAAAAGTCCGCACATTCGAGCAAAGACAGGCTTTAGCGAGTTATTAAAAACTTAGG
GGCGCTCTTGTCCCCCACAGGGCCCGACCGCACACAGCAAGGCGATGGCCCAGCTGTAAGTTGGTAGCACTGAGAACTAGCAGCGCGCGC
GGAGCCCGCTGAGACTTGAATCAATCTGGTCTAACGGTTTCCCCTAAACCGCTAGGAGCCCTCAATCGGCGGGACAGCAGGGCGCGTCCT
CTGCCACTCTCGCTCCGAGGTCCCCGCGCCAGAGACGCAGCCGCGCTCCCACCACCCACACCCACCGCGCCCTCGTTCGCCTCTTCTCCG
GGAGCCAGTCCGCGCCACCGCCGCCGCCCAGGCCATCGCCACCCTCCGCAGCCATGTCCACCAGGTCCGTGTCCTCGTCCTCCTACCGCA
GGATGTTCGGCGGCCCGGGCACCGCGAGCCGGCCGAGCTCCAGCCGGAGCTACGTGACTACGTCCACCCGCACCTACAGCCTGGGCAGCG
CGCTGCGCCCCAGCACCAGCCGCAGCCTCTACGCCTCGTCCCCGGGCGGCGTGTATGCCACGCGCTCCTCTGCCGTGCGCCTGCGGAGCA
GCGTGCCCGGGGTGCGGCTCCTGCAGGACTCGGTGGACTTCTCGCTGGCCGACGCCATCAACACCGAGTTCAAGAACACCCGCACCAACG
AGAAGGTGGAGCTGCAGGAGCTGAATGACCGCTTCGCCAACTACATCGACAAGGTGCGCTTCCTGGAGCAGCAGAATAAGATCCTGCTGG
CCGAGCTCGAGCAGCTCAAGGGCCAAGGCAAGTCGCGCCTGGGGGACCTCTACGAGGAGGAGATGCGGGAGCTGCGCCGGCAGGTGGACC
AGCTAACCAACGACAAAGCCCGCGTCGAGGTGGAGCGCGACAACCTGGCCGAGGACATCATGCGCCTCCGGGAGAAATTGCAGGAGGAGA
TGCTTCAGAGAGAGGAAGCCGAAAACACCCTGCAATCTTTCAGACAGGATGTTGACAATGCGTCTCTGGCACGTCTTGACCTTGAACGCA
AAGTGGAATCTTTGCAAGAAGAGATTGCCTTTTTGAAGAAACTCCACGAAGAGGAGATCCGTGAGTTGCAGGCTCAGCTTCAGGAACAGC
AGGTCCAGGTGGAGATGGACATGTCTAAGCCAGACCTCACTGCCGCCCTCAGGGACATCCGGGCTCAGTATGAGACCATCGCGGCTAAGA
ACATTTCTGAAGCTGAGGAGTGGTACAAGTCGAAGGTGTCAGACCTGACCCAGGCAGCCAACAAGAACAACGACGCCCTGCGCCAGGCCA
AGCAGGAGATGATGGAATACCGACACCAGATCCAGTCCTACACCTGCGAGATTGACGCCCTGAAGGGCACTAACGATTCCCTGATGAGGC
AGATGCGGGAATTGGAGGACCGATTTGCCAGTGAGGCCAGTGGCTACCAGGACAACATTGCGCGCCTGGAGGAGGAAATCCGGCACCTCA
AGGATGAGATGGCCCGCCATCTGCGCGAGTACCAGGACCTGCTCAACGTGAAGATGGCCCTGGATGTGGAGATTGCCACCTACCGGAAGC
TGCTGGAGGGAGAGGAGAGCCGGATCAATCTCCCCATCCAGACCTACTCTGCCCTCAACTTCCGAGAAACCAGCCCTGAGCAAAGGGGTT
CTGAGGTCCATACCAAGAAGACGGTGATGATCAAGACCATCGAGACACGGGATGGGGAGGTCGTCAGTGAGGCCACACAGCAGCAGCATG
AAGTGCTCTAAAGACAGAGACCCTCTGCCACCAGAGACCGTCCTCACCCCTGTCCTCACTGCTCCCTGAAGCCAGCCTTCTTCCATCCCA
GGACACCACACCCAGCCTCAGTCCTCCCCTCACAGCCTCTGACCCCTCCTCACTGGCCATCCCTCGTGGTCCCCAACAGCGACATAGCCC
ATCCCTGCCTGGTCACAGGGCATGCCCCGGCCACCTCTGCGGACCCCAGCTGTGAGCCTTGGCTGTTGGCAGTGAGTGAGCCTGGCTCTT
GTGCTGGATGGAGCCCAGGCGGGAGCGGTGGCCCTGTCCCTCCCACCTCTGTGACCTCAGGCACTAGCCTTTGGCTCTGGAGACAGCCCC
AGAGCAGGGTGTTGGGATACTGCAGGGCCAGGACTGAGCCCCGCAGACCTCCCCAGCCCCTAGCCCAGGAGAGAGAAAGCCAGGCAGGTA
GCCAGGGGGACTAGCCCCTGTGGAGACTGGGGGGCTTGAAATTGTCCCCGTGGTCTCTTACTTTCCTTTCCCCAGCCCAGGGTGGACTTA
GAAAGCAGGGGCTACAAGAGGGAATCCCCGAAGGTGCTGGAGGTGGGAGCAGGAGATTGAGAAGGAGAGAAAGTGGGTGAGATGCTGGAG
AAGAGAGGAGAGGAGAGAGGCAGAGAGCGGTCTCAGGCTGGTGGGAGGGGCGCCCACCTCCCCACGCCCTCCCCTCCCCTGCTGCAGGGG

>98108_98108_2_VIM-DES_VIM_chr10_17275681_ENST00000544301_DES_chr2_220285217_ENST00000373960_length(amino acids)=465AA_BP=84
MSTRSVSSSSYRRMFGGPGTASRPSSSRSYVTTSTRTYSLGSALRPSTSRSLYASSPGGVYATRSSAVRLRSSVPGVRLLQDSVDFSLAD
AINTEFKNTRTNEKVELQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAE
DIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHEEEIRELQAQLQEQQVQVEMDMSKPDLTAALR
DIRAQYETIAAKNISEAEEWYKSKVSDLTQAANKNNDALRQAKQEMMEYRHQIQSYTCEIDALKGTNDSLMRQMRELEDRFASEASGYQD
NIARLEEEIRHLKDEMARHLREYQDLLNVKMALDVEIATYRKLLEGEESRINLPIQTYSALNFRETSPEQRGSEVHTKKTVMIKTIETRD

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Fusion Gene PPI Analysis for VIM-DES


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneDESchr10:17275681chr2:220285217ENST0000037396029438_453245.0471.0CRYAB
TgeneDESchr10:17275681chr2:220285217ENST0000037396029268_415245.0471.0NEB


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for VIM-DES


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for VIM-DES


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneVIMC0006142Malignant neoplasm of breast4CTD_human
HgeneVIMC0678222Breast Carcinoma4CTD_human
HgeneVIMC1257931Mammary Neoplasms, Human4CTD_human
HgeneVIMC1458155Mammary Neoplasms4CTD_human
HgeneVIMC3805411CATARACT 304GENOMICS_ENGLAND;UNIPROT
HgeneVIMC4704874Mammary Carcinoma, Human4CTD_human
HgeneVIMC0023890Liver Cirrhosis2CTD_human
HgeneVIMC0029408Degenerative polyarthritis2CTD_human
HgeneVIMC0033578Prostatic Neoplasms2CTD_human
HgeneVIMC0086743Osteoarthrosis Deformans2CTD_human
HgeneVIMC0239946Fibrosis, Liver2CTD_human
HgeneVIMC0376358Malignant neoplasm of prostate2CTD_human
HgeneVIMC0007140Carcinosarcoma1CTD_human
HgeneVIMC0007621Neoplastic Cell Transformation1CTD_human
HgeneVIMC0019193Hepatitis, Toxic1CTD_human
HgeneVIMC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneVIMC0027626Neoplasm Invasiveness1CTD_human
HgeneVIMC0027627Neoplasm Metastasis1CTD_human
HgeneVIMC0027720Nephrosis1CTD_human
HgeneVIMC0031149Peritoneal Neoplasms1CTD_human
HgeneVIMC0035126Reperfusion Injury1CTD_human
HgeneVIMC0035309Retinal Diseases1CTD_human
HgeneVIMC0039101synovial sarcoma1CTD_human
HgeneVIMC0043094Weight Gain1CTD_human
HgeneVIMC0085084Motor Neuron Disease1CTD_human
HgeneVIMC0086543Cataract1CTD_human
HgeneVIMC0154681Anterior Horn Cell Disease1CTD_human
HgeneVIMC0154682Lateral Sclerosis1CTD_human
HgeneVIMC0270715Degenerative Diseases, Central Nervous System1CTD_human
HgeneVIMC0270763Familial Motor Neuron Disease1CTD_human
HgeneVIMC0270764Motor Neuron Disease, Lower1CTD_human
HgeneVIMC0345967Malignant mesothelioma1CTD_human
HgeneVIMC0346990Carcinomatosis of peritoneal cavity1CTD_human
HgeneVIMC0521659Motor Neuron Disease, Upper1CTD_human
HgeneVIMC0524524Pseudoaphakia1CTD_human
HgeneVIMC0524851Neurodegenerative Disorders1CTD_human
HgeneVIMC0543858Motor Neuron Disease, Secondary1CTD_human
HgeneVIMC0751733Degenerative Diseases, Spinal Cord1CTD_human
HgeneVIMC0860207Drug-Induced Liver Disease1CTD_human
HgeneVIMC0948089Acute Coronary Syndrome1CTD_human
HgeneVIMC1262760Hepatitis, Drug-Induced1CTD_human
HgeneVIMC1510497Lens Opacities1CTD_human
HgeneVIMC1833118Cataract, Pulverulent1ORPHANET
HgeneVIMC1852438CATARACT, COPPOCK-LIKE1ORPHANET
HgeneVIMC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
HgeneVIMC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
HgeneVIMC3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneVIMC4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneVIMC4279912Chemically-Induced Liver Toxicity1CTD_human
HgeneVIMC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human
TgeneC1832370MYOPATHY, MYOFIBRILLAR, DESMIN-RELATED38CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC1858154CARDIOMYOPATHY, DILATED, 1I6CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC1867005Scapuloperoneal Syndrome, Neurogenic, Kaeser Type5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0686353Muscular Dystrophies, Limb-Girdle3CTD_human;GENOMICS_ENGLAND
TgeneC2678065Myofibrillar Myopathy3CTD_human;GENOMICS_ENGLAND
TgeneC0004238Atrial Fibrillation1CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0007097Carcinoma1CTD_human
TgeneC0015934Fetal Growth Retardation1CTD_human
TgeneC0017658Glomerulonephritis1CTD_human
TgeneC0024623Malignant neoplasm of stomach1CTD_human
TgeneC0024667Animal Mammary Neoplasms1CTD_human
TgeneC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneC0027720Nephrosis1CTD_human
TgeneC0038356Stomach Neoplasms1CTD_human
TgeneC0205696Anaplastic carcinoma1CTD_human
TgeneC0205697Carcinoma, Spindle-Cell1CTD_human
TgeneC0205698Undifferentiated carcinoma1CTD_human
TgeneC0205699Carcinomatosis1CTD_human
TgeneC0235480Paroxysmal atrial fibrillation1CTD_human
TgeneC0235833Congenital diaphragmatic hernia1CTD_human
TgeneC0265699Congenital hernia of foramen of Morgagni1CTD_human
TgeneC0265700Congenital hernia of foramen of Bochdalek1CTD_human
TgeneC0340427Familial dilated cardiomyopathy1ORPHANET
TgeneC0598608Hyperhomocysteinemia1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC0878544Cardiomyopathies1GENOMICS_ENGLAND
TgeneC1257925Mammary Carcinoma, Animal1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC1704377Bright Disease1CTD_human
TgeneC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneC2585653Persistent atrial fibrillation1CTD_human
TgeneC3148763MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 1E1ORPHANET
TgeneC3468561familial atrial fibrillation1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human