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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPDPF-CHD3 (FusionGDB2 ID:HG79144TG1107)

Fusion Gene Summary for PPDPF-CHD3

check button Fusion gene summary
Fusion gene informationFusion gene name: PPDPF-CHD3
Fusion gene ID: hg79144tg1107
HgeneTgene
Gene symbol

PPDPF

CHD3

Gene ID

79144

1107

Gene namepancreatic progenitor cell differentiation and proliferation factorchromodomain helicase DNA binding protein 3
SynonymsC20orf149|dJ697K14.9|exdpfMi-2a|Mi2-ALPHA|SNIBCPS|ZFH
Cytomap('PPDPF')('CHD3')

20q13.33

17p13.1

Type of geneprotein-codingprotein-coding
Descriptionpancreatic progenitor cell differentiation and proliferation factorexocrine differentiation and proliferation factorpancreatic progenitor cell differentiation and proliferation factor homologchromodomain-helicase-DNA-binding protein 3ATP-dependent helicase CHD3CHD-3hZFHmi-2 autoantigen 240 kDa proteinzinc finger helicasezinc-finger helicase (Snf2-like)
Modification date2020031320200313
UniProtAcc.

Q12873

Ensembl transtripts involved in fusion geneENST00000473620, ENST00000370177, 
ENST00000370179, 
Fusion gene scores* DoF score11 X 11 X 2=24210 X 11 X 4=440
# samples 1111
** MAII scorelog2(11/242*10)=-1.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/440*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPDPF [Title/Abstract] AND CHD3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPDPF(62153141)-CHD3(7804634), # samples:1
Anticipated loss of major functional domain due to fusion event.PPDPF-CHD3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPDPF-CHD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPDPF-CHD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PPDPF-CHD3 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PPDPF-CHD3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCHD3

GO:0007051

spindle organization

17626165

TgeneCHD3

GO:0007098

centrosome cycle

17626165


check buttonFusion gene breakpoints across PPDPF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CHD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADC377192PPDPFchr20

62153141

+CHD3chr17

7804634

+


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Fusion Gene ORF analysis for PPDPF-CHD3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000473620ENST00000330494PPDPFchr20

62153141

+CHD3chr17

7804634

+
3UTR-3CDSENST00000473620ENST00000358181PPDPFchr20

62153141

+CHD3chr17

7804634

+
3UTR-3CDSENST00000473620ENST00000380358PPDPFchr20

62153141

+CHD3chr17

7804634

+
3UTR-intronENST00000473620ENST00000570758PPDPFchr20

62153141

+CHD3chr17

7804634

+
5CDS-intronENST00000370177ENST00000570758PPDPFchr20

62153141

+CHD3chr17

7804634

+
5CDS-intronENST00000370179ENST00000570758PPDPFchr20

62153141

+CHD3chr17

7804634

+
Frame-shiftENST00000370177ENST00000330494PPDPFchr20

62153141

+CHD3chr17

7804634

+
Frame-shiftENST00000370177ENST00000358181PPDPFchr20

62153141

+CHD3chr17

7804634

+
Frame-shiftENST00000370177ENST00000380358PPDPFchr20

62153141

+CHD3chr17

7804634

+
In-frameENST00000370179ENST00000330494PPDPFchr20

62153141

+CHD3chr17

7804634

+
In-frameENST00000370179ENST00000358181PPDPFchr20

62153141

+CHD3chr17

7804634

+
In-frameENST00000370179ENST00000380358PPDPFchr20

62153141

+CHD3chr17

7804634

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000370179PPDPFchr2062153141+ENST00000380358CHD3chr177804634+47327476533556967
ENST00000370179PPDPFchr2062153141+ENST00000358181CHD3chr177804634+46307476533454933
ENST00000370179PPDPFchr2062153141+ENST00000330494CHD3chr177804634+47327476533556967

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000370179ENST00000380358PPDPFchr2062153141+CHD3chr177804634+0.0031683460.9968317
ENST00000370179ENST00000358181PPDPFchr2062153141+CHD3chr177804634+0.0032504760.9967495
ENST00000370179ENST00000330494PPDPFchr2062153141+CHD3chr177804634+0.0031683460.9968317

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Fusion Genomic Features for PPDPF-CHD3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for PPDPF-CHD3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:62153141/chr17:7804634)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CHD3

Q12873

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones (PubMed:9804427, PubMed:30397230). Involved in transcriptional repressiobn as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). {ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:27068747, ECO:0000269|PubMed:30397230, ECO:0000269|PubMed:9804427}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCHD3chr20:62153141chr17:7804634ENST00000330494040206_22102001.0Compositional biasNote=Poly-Ala
TgeneCHD3chr20:62153141chr17:7804634ENST00000330494040243_24602001.0Compositional biasNote=Poly-Pro
TgeneCHD3chr20:62153141chr17:7804634ENST00000330494040355_35802001.0Compositional biasNote=Poly-Lys
TgeneCHD3chr20:62153141chr17:7804634ENST00000330494040434_44602001.0Compositional biasNote=Poly-Glu
TgeneCHD3chr20:62153141chr17:7804634ENST00000330494040697_70302001.0Compositional biasNote=Poly-Lys
TgeneCHD3chr20:62153141chr17:7804634ENST00000358181039206_22101967.0Compositional biasNote=Poly-Ala
TgeneCHD3chr20:62153141chr17:7804634ENST00000358181039243_24601967.0Compositional biasNote=Poly-Pro
TgeneCHD3chr20:62153141chr17:7804634ENST00000358181039355_35801967.0Compositional biasNote=Poly-Lys
TgeneCHD3chr20:62153141chr17:7804634ENST00000358181039434_44601967.0Compositional biasNote=Poly-Glu
TgeneCHD3chr20:62153141chr17:7804634ENST00000358181039697_70301967.0Compositional biasNote=Poly-Lys
TgeneCHD3chr20:62153141chr17:7804634ENST00000380358040206_22102060.0Compositional biasNote=Poly-Ala
TgeneCHD3chr20:62153141chr17:7804634ENST00000380358040243_24602060.0Compositional biasNote=Poly-Pro
TgeneCHD3chr20:62153141chr17:7804634ENST00000380358040355_35802060.0Compositional biasNote=Poly-Lys
TgeneCHD3chr20:62153141chr17:7804634ENST00000380358040434_44602060.0Compositional biasNote=Poly-Glu
TgeneCHD3chr20:62153141chr17:7804634ENST00000380358040697_70302060.0Compositional biasNote=Poly-Lys
TgeneCHD3chr20:62153141chr17:7804634ENST000003304940401064_122902001.0DomainHelicase C-terminal
TgeneCHD3chr20:62153141chr17:7804634ENST00000330494040494_59402001.0DomainChromo 1
TgeneCHD3chr20:62153141chr17:7804634ENST00000330494040631_67302001.0DomainChromo 2
TgeneCHD3chr20:62153141chr17:7804634ENST00000330494040748_93202001.0DomainHelicase ATP-binding
TgeneCHD3chr20:62153141chr17:7804634ENST000003581810391064_122901967.0DomainHelicase C-terminal
TgeneCHD3chr20:62153141chr17:7804634ENST00000358181039494_59401967.0DomainChromo 1
TgeneCHD3chr20:62153141chr17:7804634ENST00000358181039631_67301967.0DomainChromo 2
TgeneCHD3chr20:62153141chr17:7804634ENST00000358181039748_93201967.0DomainHelicase ATP-binding
TgeneCHD3chr20:62153141chr17:7804634ENST000003803580401064_122902060.0DomainHelicase C-terminal
TgeneCHD3chr20:62153141chr17:7804634ENST00000380358040494_59402060.0DomainChromo 1
TgeneCHD3chr20:62153141chr17:7804634ENST00000380358040631_67302060.0DomainChromo 2
TgeneCHD3chr20:62153141chr17:7804634ENST00000380358040748_93202060.0DomainHelicase ATP-binding
TgeneCHD3chr20:62153141chr17:7804634ENST00000330494040883_88602001.0MotifNote=DEAH box
TgeneCHD3chr20:62153141chr17:7804634ENST00000358181039883_88601967.0MotifNote=DEAH box
TgeneCHD3chr20:62153141chr17:7804634ENST00000380358040883_88602060.0MotifNote=DEAH box
TgeneCHD3chr20:62153141chr17:7804634ENST00000330494040761_76802001.0Nucleotide bindingATP
TgeneCHD3chr20:62153141chr17:7804634ENST00000358181039761_76801967.0Nucleotide bindingATP
TgeneCHD3chr20:62153141chr17:7804634ENST00000380358040761_76802060.0Nucleotide bindingATP
TgeneCHD3chr20:62153141chr17:7804634ENST00000330494040379_42602001.0Zinc fingerPHD-type 1
TgeneCHD3chr20:62153141chr17:7804634ENST00000330494040456_50302001.0Zinc fingerPHD-type 2
TgeneCHD3chr20:62153141chr17:7804634ENST00000358181039379_42601967.0Zinc fingerPHD-type 1
TgeneCHD3chr20:62153141chr17:7804634ENST00000358181039456_50301967.0Zinc fingerPHD-type 2
TgeneCHD3chr20:62153141chr17:7804634ENST00000380358040379_42602060.0Zinc fingerPHD-type 1
TgeneCHD3chr20:62153141chr17:7804634ENST00000380358040456_50302060.0Zinc fingerPHD-type 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PPDPF-CHD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>67367_67367_1_PPDPF-CHD3_PPDPF_chr20_62153141_ENST00000370179_CHD3_chr17_7804634_ENST00000330494_length(transcript)=4732nt_BP=747nt
GCGGCCCCCGCGCATATAAGTGGGCGCGTCCGCGCGTGCGCACCCCGCGCGCGCCTCTCTGTCGTGGCGCGGCTTCCCGCGGTCTTCTCT
GCAAATGGGCTCCGTGGCCTAGCGCCCCCGTCCCCGCCACCCGTGATCGTGCGCCGAGGCCCGCGAGGGGTCGCCGCCCAGATCCCACCA
GCCAGCAAGCTAAAGCATGGCGGCCATCCCCTCCAGCGGCTCGCTCGTGGCCACCCACGACTACTACCGGCGCCGCCTGGGTTCCACTTC
CAGCAACAGCTCCTGCAGCAGTACCGAGTGCCCCGGGGAAGCCATTCCCCACCCCCCAGCAGCATGACCGCCTGTGGCCTGGCTCGGGAC
GCCCCGAGGAAGCAGCCCGGCGGTCAGTCCAGCACAGCCAGCGCTGGGCCCCCGTCCTGACCTGAGCGGTTACCACCAGCCCCAGGCCTG
CGGAGGCGCTAGTCCACCAGAGCCCCTCCCCGCCCCTCTCCCCACTCCGCATCCCTCGCCCCCCTCCCCACCTCCCACCCCCCACCCTGT
AAACTAGGCGGCTGCAGCAAGCAGACCTTCGCATCAACACAGCAGACACCAAAAACCAGTGAGAGCCCCGCTCTCTACCGCCCGGCCCCA
GCACTCGCTAGCTTTCCTGACACCTGGAACTGTGCACCTGGCACCAAGCGGAAAATAAACTCCAAGCAGCCAGTAGCCCCGATGGTGTGT
GCCTGAGCTGTGTGGCCCGAGGTTCCATCCAGAAGATGCTGCGAAAGCTGAAGGAGCAAGGACACCGAGTGCTCATCTTCTCGCAGATGA
CCAAAATGTTAGACTTGCTTGAGGACTTCTTAGACTATGAAGGCTACAAGTATGAGCGCATCGATGGTGGTATCACGGGTGCCCTGAGGC
AGGAGGCCATCGATCGGTTTAATGCTCCTGGGGCCCAACAATTCTGCTTCCTCCTGTCCACCCGAGCTGGGGGCCTGGGCATCAATCTGG
CCACTGCTGACACTGTCATCATCTTTGATTCTGACTGGAACCCCCATAATGACATCCAGGCCTTTAGCCGGGCTCATCGGATTGGCCAGG
CCAACAAAGTGATGATTTACCGGTTTGTGACTCGCGCGTCAGTGGAAGAGCGAATCACACAAGTGGCCAAGAGAAAGATGATGCTGACAC
ACCTGGTTGTGCGGCCTGGGCTGGGCTCCAAGGCAGGCTCCATGTCCAAGCAGGAGCTTGACGACATTCTCAAATTTGGCACTGAAGAGC
TATTCAAGGATGAAAACGAGGGGGAGAACAAGGAGGAGGACAGCAGTGTGATTCATTATGACAATGAGGCCATCGCTCGGCTGTTGGACC
GGAACCAGGATGCAACTGAGGACACTGACGTGCAGAACATGAATGAGTATCTCAGCTCCTTCAAGGTGGCACAGTACGTCGTGCGGGAAG
AAGACAAGATTGAGGAAATTGAGCGAGAGATCATCAAGCAGGAGGAGAATGTGGACCCTGACTACTGGGAGAAGCTGCTGAGGCATCACT
ATGAGCAACAGCAGGAAGACCTAGCCCGGAATCTAGGCAAGGGCAAGCGGGTTCGCAAGCAAGTTAACTACAATGATGCTGCTCAGGAAG
ACCAAGACAACCAGTCAGAGTACTCGGTGGGTTCAGAGGAGGAGGATGAAGACTTCGATGAACGTCCTGAAGGGCGTAGACAGTCAAAGA
GGCAGCTCCGGAATGAGAAAGATAAGCCACTGCCTCCACTGCTGGCCCGAGTCGGGGGCAACATTGAGGTGCTGGGCTTCAACACCCGTC
AGCGGAAGGCTTTCCTCAATGCTGTGATGCGCTGGGGGATGCCACCACAGGATGCCTTCACCACACAGTGGCTGGTGCGGGACCTGAGGG
GCAAGACTGAGAAGGAGTTTAAGGCCTATGTGTCTTTGTTCATGCGCCATCTGTGTGAGCCTGGGGCAGACGGCTCTGAAACCTTTGCCG
ATGGGGTCCCTCGGGAGGGACTGAGTCGCCAGCAGGTGTTGACCCGCATTGGAGTCATGTCTCTCGTCAAAAAGAAGGTGCAGGAGTTTG
AGCACATCAATGGGCGTTGGTCAATGCCGGAACTGATGCCTGACCCCAGCGCCGATTCTAAGCGCTCCTCCAGAGCCTCCTCTCCTACCA
AAACGTCTCCCACCACTCCTGAGGCTTCTGCTACCAACAGTCCCTGCACCTCTAAACCTGCTACTCCAGCTCCAAGTGAGAAAGGAGAAG
GCATAAGGACACCTCTTGAGAAGGAGGAAGCTGAAAACCAGGAGGAAAAGCCAGAGAAGAACAGCAGAATTGGGGAGAAGATGGAGACAG
AGGCTGATGCCCCCAGCCCAGCCCCATCACTTGGGGAGCGGCTGGAGCCAAGGAAGATTCCTCTAGAGGATGAGGTGCCAGGGGTGCCTG
GAGAGATGGAGCCTGAACCTGGGTACCGTGGGGACAGAGAGAAGTCAGCCACAGAGTCGACGCCAGGAGAAAGGGGGGAGGAGAAGCCGT
TGGATGGACAGGAACACAGGGAGAGGCCGGAGGGGGAAACAGGGGATTTGGGCAAGAGAGAAGATGTAAAAGGTGACCGGGAGCTTCGAC
CAGGGCCTCGAGATGAGCCACGGTCCAATGGGCGACGAGAGGAAAAGACAGAGAAGCCCCGGTTCATGTTCAATATCGCCGATGGTGGCT
TCACAGAGCTTCACACACTGTGGCAGAATGAGGAACGGGCAGCTATTTCCTCGGGGAAACTCAATGAGATCTGGCACAGAAGACATGACT
ATTGGCTTCTGGCTGGGATTGTCCTCCATGGCTATGCACGGTGGCAGGACATCCAGAATGATGCTCAATTTGCCATTATCAACGAGCCAT
TTAAAACTGAAGCCAATAAGGGGAACTTTCTGGAGATGAAAAATAAGTTCCTGGCCCGGAGGTTCAAGCTCCTGGAGCAGGCGCTGGTGA
TTGAGGAGCAGCTGCGGCGGGCGGCCTACCTGAACCTGTCGCAGGAGCCGGCGCACCCCGCCATGGCCCTCCACGCCCGCTTCGCCGAGG
CCGAGTGCCTGGCCGAGAGCCACCAGCACCTCTCCAAGGAGTCGCTGGCGGGGAACAAGCCGGCCAACGCCGTCCTGCACAAGGTTCTGA
ACCAGCTGGAGGAGTTGCTGAGCGACATGAAGGCGGACGTGACCCGCCTGCCAGCCACGCTGTCCCGAATACCCCCCATCGCAGCCCGCC
TTCAGATGTCCGAGCGCAGCATCCTCAGCCGGCTGGCCAGCAAGGGCACGGAGCCTCACCCCACACCGGCCTACCCGCCGGGTCCCTACG
CTACACCTCCGGGGTACGGGGCGGCCTTCAGCGCCGCACCCGTAGGGGCCCTGGCCGCCGCAGGCGCCAATTACAGCCAGATGCCTGCAG
GGTCCTTCATCACAGCCGCCACCAACGGCCCTCCAGTGCTTGTGAAGAAGGAGAAGGAAATGGTGGGGGCATTGGTGTCAGACGGGCTGG
ATCGGAAGGAGCCCCGAGCCGGGGAGGTGATCTGTATAGACGACTGACTGGATCCCAGGCCTGCCCTTCACCCAGGCCCCGTCCCCGAGG
CCGACCCCCAGCTCAAGCGCTGGGGCCTGCTGCCAGCCCTCCACCTTCCCCACCCCTTGGGCCATCACTGGGCTAGGAACCCCTTTGCCC
CTCTCTGCAGCTCCTCTCTTCAAGAAGGGCCCTTTGTCTTTCTCCACTCCCACACACCTTTCCCACCAAGCCTTGAAGACTGTGCTGGTG
AGAAGAAGTCTGGGTGGGAGATGGCTGGCAGGGTCTTCCAAGTACCTTCCTCCCACACTGCCAAGTATACACAACTTCCCAGTAAATGGT
TGTGGGGAGGAAAGAGGTGGAGCCTCCCCAGCCGTTTCCCTGCAGAATCAGCTCTGTCTCATGTGGAAGTGGAGAATCAGCCTTGCCTGG
CCTTTAGGAACTTTTGTGGGGAAGAGAGCTTTGAAGAGAGGAGGGGGACTTTAGAGAGGGATGAAAATGAGCCCTGGGAGGGAGGAAGGG
ACGAGGAGGGGTGGCTGCATGTTACCGTCCCCTACCTCTCCCCACGTGGAGGGTGGAGCAGTTATGAGGGAGGAAGTCAACTGCTGTTCA
GCCTCAGAATAAAGGTGCCGTTCACTGGCTCAGTTACCTCCTGTGTACCGGCATCTTGTGTTGGGAATGTTCCCCCCTCCCTAGGGACCA
AGGACCACCCCTACAAAAAGAGTAATGGTTGGGTGATACTCCCTCAAGCCAAAGAGGAGCTCCCCAACCTGTTCTAGGGACCCAGGTAAC
CTAGAAGGGTGGGAGAGAATACAATGGGCCAGATGTGGTGGAAGCCCAGCTCTGGGGCTCAGGTTCCTGGAAGACTTCTACTACCCTCCC
TCCTCAAGGCCTGGATACAGACTAAATTTGTATAAGTCAGGCAGGGGACCTAGTCAGGGTCTTGGGAGCTACCTTGTCGTTGGGACCAGA
GCAAAATAGTGGAGGGCAGGCTAGGGAAATGTGGGCACATCCCCCCTCCCAGGAGGGGCCGGGGAGAGTGGCAGTTTGCATGGCGAACCC
CCCACTTCCTCTTTGCTGCCCCTTCACTTTCTTGCTGCCCCTTTCCCAGTCTCTCTTCACACCCACTCCTGGTCTGTCCTGATCCCCTCT

>67367_67367_1_PPDPF-CHD3_PPDPF_chr20_62153141_ENST00000370179_CHD3_chr17_7804634_ENST00000330494_length(amino acids)=967AA_BP=32
MELCTWHQAENKLQAASSPDGVCLSCVARGSIQKMLRKLKEQGHRVLIFSQMTKMLDLLEDFLDYEGYKYERIDGGITGALRQEAIDRFN
APGAQQFCFLLSTRAGGLGINLATADTVIIFDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGL
GSKAGSMSKQELDDILKFGTEELFKDENEGENKEEDSSVIHYDNEAIARLLDRNQDATEDTDVQNMNEYLSSFKVAQYVVREEDKIEEIE
REIIKQEENVDPDYWEKLLRHHYEQQQEDLARNLGKGKRVRKQVNYNDAAQEDQDNQSEYSVGSEEEDEDFDERPEGRRQSKRQLRNEKD
KPLPPLLARVGGNIEVLGFNTRQRKAFLNAVMRWGMPPQDAFTTQWLVRDLRGKTEKEFKAYVSLFMRHLCEPGADGSETFADGVPREGL
SRQQVLTRIGVMSLVKKKVQEFEHINGRWSMPELMPDPSADSKRSSRASSPTKTSPTTPEASATNSPCTSKPATPAPSEKGEGIRTPLEK
EEAENQEEKPEKNSRIGEKMETEADAPSPAPSLGERLEPRKIPLEDEVPGVPGEMEPEPGYRGDREKSATESTPGERGEEKPLDGQEHRE
RPEGETGDLGKREDVKGDRELRPGPRDEPRSNGRREEKTEKPRFMFNIADGGFTELHTLWQNEERAAISSGKLNEIWHRRHDYWLLAGIV
LHGYARWQDIQNDAQFAIINEPFKTEANKGNFLEMKNKFLARRFKLLEQALVIEEQLRRAAYLNLSQEPAHPAMALHARFAEAECLAESH
QHLSKESLAGNKPANAVLHKVLNQLEELLSDMKADVTRLPATLSRIPPIAARLQMSERSILSRLASKGTEPHPTPAYPPGPYATPPGYGA

--------------------------------------------------------------
>67367_67367_2_PPDPF-CHD3_PPDPF_chr20_62153141_ENST00000370179_CHD3_chr17_7804634_ENST00000358181_length(transcript)=4630nt_BP=747nt
GCGGCCCCCGCGCATATAAGTGGGCGCGTCCGCGCGTGCGCACCCCGCGCGCGCCTCTCTGTCGTGGCGCGGCTTCCCGCGGTCTTCTCT
GCAAATGGGCTCCGTGGCCTAGCGCCCCCGTCCCCGCCACCCGTGATCGTGCGCCGAGGCCCGCGAGGGGTCGCCGCCCAGATCCCACCA
GCCAGCAAGCTAAAGCATGGCGGCCATCCCCTCCAGCGGCTCGCTCGTGGCCACCCACGACTACTACCGGCGCCGCCTGGGTTCCACTTC
CAGCAACAGCTCCTGCAGCAGTACCGAGTGCCCCGGGGAAGCCATTCCCCACCCCCCAGCAGCATGACCGCCTGTGGCCTGGCTCGGGAC
GCCCCGAGGAAGCAGCCCGGCGGTCAGTCCAGCACAGCCAGCGCTGGGCCCCCGTCCTGACCTGAGCGGTTACCACCAGCCCCAGGCCTG
CGGAGGCGCTAGTCCACCAGAGCCCCTCCCCGCCCCTCTCCCCACTCCGCATCCCTCGCCCCCCTCCCCACCTCCCACCCCCCACCCTGT
AAACTAGGCGGCTGCAGCAAGCAGACCTTCGCATCAACACAGCAGACACCAAAAACCAGTGAGAGCCCCGCTCTCTACCGCCCGGCCCCA
GCACTCGCTAGCTTTCCTGACACCTGGAACTGTGCACCTGGCACCAAGCGGAAAATAAACTCCAAGCAGCCAGTAGCCCCGATGGTGTGT
GCCTGAGCTGTGTGGCCCGAGGTTCCATCCAGAAGATGCTGCGAAAGCTGAAGGAGCAAGGACACCGAGTGCTCATCTTCTCGCAGATGA
CCAAAATGTTAGACTTGCTTGAGGACTTCTTAGACTATGAAGGCTACAAGTATGAGCGCATCGATGGTGGTATCACGGGTGCCCTGAGGC
AGGAGGCCATCGATCGGTTTAATGCTCCTGGGGCCCAACAATTCTGCTTCCTCCTGTCCACCCGAGCTGGGGGCCTGGGCATCAATCTGG
CCACTGCTGACACTGTCATCATCTTTGATTCTGACTGGAACCCCCATAATGACATCCAGGCCTTTAGCCGGGCTCATCGGATTGGCCAGG
CCAACAAAGTGATGATTTACCGGTTTGTGACTCGCGCGTCAGTGGAAGAGCGAATCACACAAGTGGCCAAGAGAAAGATGATGCTGACAC
ACCTGGTTGTGCGGCCTGGGCTGGGCTCCAAGGCAGGCTCCATGTCCAAGCAGGAGCTTGACGACATTCTCAAATTTGGCACTGAAGAGC
TATTCAAGGATGAAAACGAGGGGGAGAACAAGGAGGAGGACAGCAGTGTGATTCATTATGACAATGAGGCCATCGCTCGGCTGTTGGACC
GGAACCAGGATGCAACTGAGGACACTGACGTGCAGAACATGAATGAGTATCTCAGCTCCTTCAAGGTGGCACAGTACGTCGTGCGGGAAG
AAGACAAGATTGAGGAAATTGAGCGAGAGATCATCAAGCAGGAGGAGAATGTGGACCCTGACTACTGGGAGAAGCTGCTGAGGCATCACT
ATGAGCAACAGCAGGAAGACCTAGCCCGGAATCTAGGCAAGGGCAAGCGGGTTCGCAAGCAAGTTAACTACAATGATGCTGCTCAGGAAG
ACCAAGACAACCAGTCAGAGTACTCGGTGGGTTCAGAGGAGGAGGATGAAGACTTCGATGAACGTCCTGAAGGGCGTAGACAGTCAAAGA
GGCAGCTCCGGAATGAGAAAGATAAGCCACTGCCTCCACTGCTGGCCCGAGTCGGGGGCAACATTGAGGTGCTGGGCTTCAACACCCGTC
AGCGGAAGGCTTTCCTCAATGCTGTGATGCGCTGGGGGATGCCACCACAGGATGCCTTCACCACACAGTGGCTGGTGCGGGACCTGAGGG
GCAAGACTGAGAAGGAGTTTAAGGCCTATGTGTCTTTGTTCATGCGCCATCTGTGTGAGCCTGGGGCAGACGGCTCTGAAACCTTTGCCG
ATGGGGTCCCTCGGGAGGGACTGAGTCGCCAGCAGGTGTTGACCCGCATTGGAGTCATGTCTCTCGTCAAAAAGAAGGTGCAGGAGTTTG
AGCACATCAATGGGCGTTGGTCAATGCCGGAACTGATGCCTGACCCCAGCGCCGATTCTAAGCGCTCCTCCAGAGCCTCCTCTCCTACCA
AAACGTCTCCCACCACTCCTGAGGCTTCTGCTACCAACAGTCCCTGCACCTCTAAACCTGCTACTCCAGCTCCAAGTGAGAAAGGAGAAG
GCATAAGGACACCTCTTGAGAAGGAGGAAGCTGAAAACCAGGAGGAAAAGCCAGAGAAGAACAGCAGAATTGGGGAGAAGATGGAGACAG
AGGCTGATGCCCCCAGCCCAGCCCCATCACTTGGGGAGCGGCTGGAGCCAAGGAAGATTCCTCTAGAGGATGAGGTGCCAGGGGTGCCTG
GAGAGATGGAGCCTGAACCTGGGTACCGTGGGGACAGAGAGAAGTCAGAAGATGTAAAAGGTGACCGGGAGCTTCGACCAGGGCCTCGAG
ATGAGCCACGGTCCAATGGGCGACGAGAGGAAAAGACAGAGAAGCCCCGGTTCATGTTCAATATCGCCGATGGTGGCTTCACAGAGCTTC
ACACACTGTGGCAGAATGAGGAACGGGCAGCTATTTCCTCGGGGAAACTCAATGAGATCTGGCACAGAAGACATGACTATTGGCTTCTGG
CTGGGATTGTCCTCCATGGCTATGCACGGTGGCAGGACATCCAGAATGATGCTCAATTTGCCATTATCAACGAGCCATTTAAAACTGAAG
CCAATAAGGGGAACTTTCTGGAGATGAAAAATAAGTTCCTGGCCCGGAGGTTCAAGCTCCTGGAGCAGGCGCTGGTGATTGAGGAGCAGC
TGCGGCGGGCGGCCTACCTGAACCTGTCGCAGGAGCCGGCGCACCCCGCCATGGCCCTCCACGCCCGCTTCGCCGAGGCCGAGTGCCTGG
CCGAGAGCCACCAGCACCTCTCCAAGGAGTCGCTGGCGGGGAACAAGCCGGCCAACGCCGTCCTGCACAAGGTTCTGAACCAGCTGGAGG
AGTTGCTGAGCGACATGAAGGCGGACGTGACCCGCCTGCCAGCCACGCTGTCCCGAATACCCCCCATCGCAGCCCGCCTTCAGATGTCCG
AGCGCAGCATCCTCAGCCGGCTGGCCAGCAAGGGCACGGAGCCTCACCCCACACCGGCCTACCCGCCGGGTCCCTACGCTACACCTCCGG
GGTACGGGGCGGCCTTCAGCGCCGCACCCGTAGGGGCCCTGGCCGCCGCAGGCGCCAATTACAGCCAGATGCCTGCAGGGTCCTTCATCA
CAGCCGCCACCAACGGCCCTCCAGTGCTTGTGAAGAAGGAGAAGGAAATGGTGGGGGCATTGGTGTCAGACGGGCTGGATCGGAAGGAGC
CCCGAGCCGGGGAGGTGATCTGTATAGACGACTGACTGGATCCCAGGCCTGCCCTTCACCCAGGCCCCGTCCCCGAGGCCGACCCCCAGC
TCAAGCGCTGGGGCCTGCTGCCAGCCCTCCACCTTCCCCACCCCTTGGGCCATCACTGGGCTAGGAACCCCTTTGCCCCTCTCTGCAGCT
CCTCTCTTCAAGAAGGGCCCTTTGTCTTTCTCCACTCCCACACACCTTTCCCACCAAGCCTTGAAGACTGTGCTGGTGAGAAGAAGTCTG
GGTGGGAGATGGCTGGCAGGGTCTTCCAAGTACCTTCCTCCCACACTGCCAAGTATACACAACTTCCCAGTAAATGGTTGTGGGGAGGAA
AGAGGTGGAGCCTCCCCAGCCGTTTCCCTGCAGAATCAGCTCTGTCTCATGTGGAAGTGGAGAATCAGCCTTGCCTGGCCTTTAGGAACT
TTTGTGGGGAAGAGAGCTTTGAAGAGAGGAGGGGGACTTTAGAGAGGGATGAAAATGAGCCCTGGGAGGGAGGAAGGGACGAGGAGGGGT
GGCTGCATGTTACCGTCCCCTACCTCTCCCCACGTGGAGGGTGGAGCAGTTATGAGGGAGGAAGTCAACTGCTGTTCAGCCTCAGAATAA
AGGTGCCGTTCACTGGCTCAGTTACCTCCTGTGTACCGGCATCTTGTGTTGGGAATGTTCCCCCCTCCCTAGGGACCAAGGACCACCCCT
ACAAAAAGAGTAATGGTTGGGTGATACTCCCTCAAGCCAAAGAGGAGCTCCCCAACCTGTTCTAGGGACCCAGGTAACCTAGAAGGGTGG
GAGAGAATACAATGGGCCAGATGTGGTGGAAGCCCAGCTCTGGGGCTCAGGTTCCTGGAAGACTTCTACTACCCTCCCTCCTCAAGGCCT
GGATACAGACTAAATTTGTATAAGTCAGGCAGGGGACCTAGTCAGGGTCTTGGGAGCTACCTTGTCGTTGGGACCAGAGCAAAATAGTGG
AGGGCAGGCTAGGGAAATGTGGGCACATCCCCCCTCCCAGGAGGGGCCGGGGAGAGTGGCAGTTTGCATGGCGAACCCCCCACTTCCTCT
TTGCTGCCCCTTCACTTTCTTGCTGCCCCTTTCCCAGTCTCTCTTCACACCCACTCCTGGTCTGTCCTGATCCCCTCTTCTGTATCAGGT

>67367_67367_2_PPDPF-CHD3_PPDPF_chr20_62153141_ENST00000370179_CHD3_chr17_7804634_ENST00000358181_length(amino acids)=933AA_BP=32
MELCTWHQAENKLQAASSPDGVCLSCVARGSIQKMLRKLKEQGHRVLIFSQMTKMLDLLEDFLDYEGYKYERIDGGITGALRQEAIDRFN
APGAQQFCFLLSTRAGGLGINLATADTVIIFDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGL
GSKAGSMSKQELDDILKFGTEELFKDENEGENKEEDSSVIHYDNEAIARLLDRNQDATEDTDVQNMNEYLSSFKVAQYVVREEDKIEEIE
REIIKQEENVDPDYWEKLLRHHYEQQQEDLARNLGKGKRVRKQVNYNDAAQEDQDNQSEYSVGSEEEDEDFDERPEGRRQSKRQLRNEKD
KPLPPLLARVGGNIEVLGFNTRQRKAFLNAVMRWGMPPQDAFTTQWLVRDLRGKTEKEFKAYVSLFMRHLCEPGADGSETFADGVPREGL
SRQQVLTRIGVMSLVKKKVQEFEHINGRWSMPELMPDPSADSKRSSRASSPTKTSPTTPEASATNSPCTSKPATPAPSEKGEGIRTPLEK
EEAENQEEKPEKNSRIGEKMETEADAPSPAPSLGERLEPRKIPLEDEVPGVPGEMEPEPGYRGDREKSEDVKGDRELRPGPRDEPRSNGR
REEKTEKPRFMFNIADGGFTELHTLWQNEERAAISSGKLNEIWHRRHDYWLLAGIVLHGYARWQDIQNDAQFAIINEPFKTEANKGNFLE
MKNKFLARRFKLLEQALVIEEQLRRAAYLNLSQEPAHPAMALHARFAEAECLAESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKA
DVTRLPATLSRIPPIAARLQMSERSILSRLASKGTEPHPTPAYPPGPYATPPGYGAAFSAAPVGALAAAGANYSQMPAGSFITAATNGPP

--------------------------------------------------------------
>67367_67367_3_PPDPF-CHD3_PPDPF_chr20_62153141_ENST00000370179_CHD3_chr17_7804634_ENST00000380358_length(transcript)=4732nt_BP=747nt
GCGGCCCCCGCGCATATAAGTGGGCGCGTCCGCGCGTGCGCACCCCGCGCGCGCCTCTCTGTCGTGGCGCGGCTTCCCGCGGTCTTCTCT
GCAAATGGGCTCCGTGGCCTAGCGCCCCCGTCCCCGCCACCCGTGATCGTGCGCCGAGGCCCGCGAGGGGTCGCCGCCCAGATCCCACCA
GCCAGCAAGCTAAAGCATGGCGGCCATCCCCTCCAGCGGCTCGCTCGTGGCCACCCACGACTACTACCGGCGCCGCCTGGGTTCCACTTC
CAGCAACAGCTCCTGCAGCAGTACCGAGTGCCCCGGGGAAGCCATTCCCCACCCCCCAGCAGCATGACCGCCTGTGGCCTGGCTCGGGAC
GCCCCGAGGAAGCAGCCCGGCGGTCAGTCCAGCACAGCCAGCGCTGGGCCCCCGTCCTGACCTGAGCGGTTACCACCAGCCCCAGGCCTG
CGGAGGCGCTAGTCCACCAGAGCCCCTCCCCGCCCCTCTCCCCACTCCGCATCCCTCGCCCCCCTCCCCACCTCCCACCCCCCACCCTGT
AAACTAGGCGGCTGCAGCAAGCAGACCTTCGCATCAACACAGCAGACACCAAAAACCAGTGAGAGCCCCGCTCTCTACCGCCCGGCCCCA
GCACTCGCTAGCTTTCCTGACACCTGGAACTGTGCACCTGGCACCAAGCGGAAAATAAACTCCAAGCAGCCAGTAGCCCCGATGGTGTGT
GCCTGAGCTGTGTGGCCCGAGGTTCCATCCAGAAGATGCTGCGAAAGCTGAAGGAGCAAGGACACCGAGTGCTCATCTTCTCGCAGATGA
CCAAAATGTTAGACTTGCTTGAGGACTTCTTAGACTATGAAGGCTACAAGTATGAGCGCATCGATGGTGGTATCACGGGTGCCCTGAGGC
AGGAGGCCATCGATCGGTTTAATGCTCCTGGGGCCCAACAATTCTGCTTCCTCCTGTCCACCCGAGCTGGGGGCCTGGGCATCAATCTGG
CCACTGCTGACACTGTCATCATCTTTGATTCTGACTGGAACCCCCATAATGACATCCAGGCCTTTAGCCGGGCTCATCGGATTGGCCAGG
CCAACAAAGTGATGATTTACCGGTTTGTGACTCGCGCGTCAGTGGAAGAGCGAATCACACAAGTGGCCAAGAGAAAGATGATGCTGACAC
ACCTGGTTGTGCGGCCTGGGCTGGGCTCCAAGGCAGGCTCCATGTCCAAGCAGGAGCTTGACGACATTCTCAAATTTGGCACTGAAGAGC
TATTCAAGGATGAAAACGAGGGGGAGAACAAGGAGGAGGACAGCAGTGTGATTCATTATGACAATGAGGCCATCGCTCGGCTGTTGGACC
GGAACCAGGATGCAACTGAGGACACTGACGTGCAGAACATGAATGAGTATCTCAGCTCCTTCAAGGTGGCACAGTACGTCGTGCGGGAAG
AAGACAAGATTGAGGAAATTGAGCGAGAGATCATCAAGCAGGAGGAGAATGTGGACCCTGACTACTGGGAGAAGCTGCTGAGGCATCACT
ATGAGCAACAGCAGGAAGACCTAGCCCGGAATCTAGGCAAGGGCAAGCGGGTTCGCAAGCAAGTTAACTACAATGATGCTGCTCAGGAAG
ACCAAGACAACCAGTCAGAGTACTCGGTGGGTTCAGAGGAGGAGGATGAAGACTTCGATGAACGTCCTGAAGGGCGTAGACAGTCAAAGA
GGCAGCTCCGGAATGAGAAAGATAAGCCACTGCCTCCACTGCTGGCCCGAGTCGGGGGCAACATTGAGGTGCTGGGCTTCAACACCCGTC
AGCGGAAGGCTTTCCTCAATGCTGTGATGCGCTGGGGGATGCCACCACAGGATGCCTTCACCACACAGTGGCTGGTGCGGGACCTGAGGG
GCAAGACTGAGAAGGAGTTTAAGGCCTATGTGTCTTTGTTCATGCGCCATCTGTGTGAGCCTGGGGCAGACGGCTCTGAAACCTTTGCCG
ATGGGGTCCCTCGGGAGGGACTGAGTCGCCAGCAGGTGTTGACCCGCATTGGAGTCATGTCTCTCGTCAAAAAGAAGGTGCAGGAGTTTG
AGCACATCAATGGGCGTTGGTCAATGCCGGAACTGATGCCTGACCCCAGCGCCGATTCTAAGCGCTCCTCCAGAGCCTCCTCTCCTACCA
AAACGTCTCCCACCACTCCTGAGGCTTCTGCTACCAACAGTCCCTGCACCTCTAAACCTGCTACTCCAGCTCCAAGTGAGAAAGGAGAAG
GCATAAGGACACCTCTTGAGAAGGAGGAAGCTGAAAACCAGGAGGAAAAGCCAGAGAAGAACAGCAGAATTGGGGAGAAGATGGAGACAG
AGGCTGATGCCCCCAGCCCAGCCCCATCACTTGGGGAGCGGCTGGAGCCAAGGAAGATTCCTCTAGAGGATGAGGTGCCAGGGGTGCCTG
GAGAGATGGAGCCTGAACCTGGGTACCGTGGGGACAGAGAGAAGTCAGCCACAGAGTCGACGCCAGGAGAAAGGGGGGAGGAGAAGCCGT
TGGATGGACAGGAACACAGGGAGAGGCCGGAGGGGGAAACAGGGGATTTGGGCAAGAGAGAAGATGTAAAAGGTGACCGGGAGCTTCGAC
CAGGGCCTCGAGATGAGCCACGGTCCAATGGGCGACGAGAGGAAAAGACAGAGAAGCCCCGGTTCATGTTCAATATCGCCGATGGTGGCT
TCACAGAGCTTCACACACTGTGGCAGAATGAGGAACGGGCAGCTATTTCCTCGGGGAAACTCAATGAGATCTGGCACAGAAGACATGACT
ATTGGCTTCTGGCTGGGATTGTCCTCCATGGCTATGCACGGTGGCAGGACATCCAGAATGATGCTCAATTTGCCATTATCAACGAGCCAT
TTAAAACTGAAGCCAATAAGGGGAACTTTCTGGAGATGAAAAATAAGTTCCTGGCCCGGAGGTTCAAGCTCCTGGAGCAGGCGCTGGTGA
TTGAGGAGCAGCTGCGGCGGGCGGCCTACCTGAACCTGTCGCAGGAGCCGGCGCACCCCGCCATGGCCCTCCACGCCCGCTTCGCCGAGG
CCGAGTGCCTGGCCGAGAGCCACCAGCACCTCTCCAAGGAGTCGCTGGCGGGGAACAAGCCGGCCAACGCCGTCCTGCACAAGGTTCTGA
ACCAGCTGGAGGAGTTGCTGAGCGACATGAAGGCGGACGTGACCCGCCTGCCAGCCACGCTGTCCCGAATACCCCCCATCGCAGCCCGCC
TTCAGATGTCCGAGCGCAGCATCCTCAGCCGGCTGGCCAGCAAGGGCACGGAGCCTCACCCCACACCGGCCTACCCGCCGGGTCCCTACG
CTACACCTCCGGGGTACGGGGCGGCCTTCAGCGCCGCACCCGTAGGGGCCCTGGCCGCCGCAGGCGCCAATTACAGCCAGATGCCTGCAG
GGTCCTTCATCACAGCCGCCACCAACGGCCCTCCAGTGCTTGTGAAGAAGGAGAAGGAAATGGTGGGGGCATTGGTGTCAGACGGGCTGG
ATCGGAAGGAGCCCCGAGCCGGGGAGGTGATCTGTATAGACGACTGACTGGATCCCAGGCCTGCCCTTCACCCAGGCCCCGTCCCCGAGG
CCGACCCCCAGCTCAAGCGCTGGGGCCTGCTGCCAGCCCTCCACCTTCCCCACCCCTTGGGCCATCACTGGGCTAGGAACCCCTTTGCCC
CTCTCTGCAGCTCCTCTCTTCAAGAAGGGCCCTTTGTCTTTCTCCACTCCCACACACCTTTCCCACCAAGCCTTGAAGACTGTGCTGGTG
AGAAGAAGTCTGGGTGGGAGATGGCTGGCAGGGTCTTCCAAGTACCTTCCTCCCACACTGCCAAGTATACACAACTTCCCAGTAAATGGT
TGTGGGGAGGAAAGAGGTGGAGCCTCCCCAGCCGTTTCCCTGCAGAATCAGCTCTGTCTCATGTGGAAGTGGAGAATCAGCCTTGCCTGG
CCTTTAGGAACTTTTGTGGGGAAGAGAGCTTTGAAGAGAGGAGGGGGACTTTAGAGAGGGATGAAAATGAGCCCTGGGAGGGAGGAAGGG
ACGAGGAGGGGTGGCTGCATGTTACCGTCCCCTACCTCTCCCCACGTGGAGGGTGGAGCAGTTATGAGGGAGGAAGTCAACTGCTGTTCA
GCCTCAGAATAAAGGTGCCGTTCACTGGCTCAGTTACCTCCTGTGTACCGGCATCTTGTGTTGGGAATGTTCCCCCCTCCCTAGGGACCA
AGGACCACCCCTACAAAAAGAGTAATGGTTGGGTGATACTCCCTCAAGCCAAAGAGGAGCTCCCCAACCTGTTCTAGGGACCCAGGTAAC
CTAGAAGGGTGGGAGAGAATACAATGGGCCAGATGTGGTGGAAGCCCAGCTCTGGGGCTCAGGTTCCTGGAAGACTTCTACTACCCTCCC
TCCTCAAGGCCTGGATACAGACTAAATTTGTATAAGTCAGGCAGGGGACCTAGTCAGGGTCTTGGGAGCTACCTTGTCGTTGGGACCAGA
GCAAAATAGTGGAGGGCAGGCTAGGGAAATGTGGGCACATCCCCCCTCCCAGGAGGGGCCGGGGAGAGTGGCAGTTTGCATGGCGAACCC
CCCACTTCCTCTTTGCTGCCCCTTCACTTTCTTGCTGCCCCTTTCCCAGTCTCTCTTCACACCCACTCCTGGTCTGTCCTGATCCCCTCT

>67367_67367_3_PPDPF-CHD3_PPDPF_chr20_62153141_ENST00000370179_CHD3_chr17_7804634_ENST00000380358_length(amino acids)=967AA_BP=32
MELCTWHQAENKLQAASSPDGVCLSCVARGSIQKMLRKLKEQGHRVLIFSQMTKMLDLLEDFLDYEGYKYERIDGGITGALRQEAIDRFN
APGAQQFCFLLSTRAGGLGINLATADTVIIFDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGL
GSKAGSMSKQELDDILKFGTEELFKDENEGENKEEDSSVIHYDNEAIARLLDRNQDATEDTDVQNMNEYLSSFKVAQYVVREEDKIEEIE
REIIKQEENVDPDYWEKLLRHHYEQQQEDLARNLGKGKRVRKQVNYNDAAQEDQDNQSEYSVGSEEEDEDFDERPEGRRQSKRQLRNEKD
KPLPPLLARVGGNIEVLGFNTRQRKAFLNAVMRWGMPPQDAFTTQWLVRDLRGKTEKEFKAYVSLFMRHLCEPGADGSETFADGVPREGL
SRQQVLTRIGVMSLVKKKVQEFEHINGRWSMPELMPDPSADSKRSSRASSPTKTSPTTPEASATNSPCTSKPATPAPSEKGEGIRTPLEK
EEAENQEEKPEKNSRIGEKMETEADAPSPAPSLGERLEPRKIPLEDEVPGVPGEMEPEPGYRGDREKSATESTPGERGEEKPLDGQEHRE
RPEGETGDLGKREDVKGDRELRPGPRDEPRSNGRREEKTEKPRFMFNIADGGFTELHTLWQNEERAAISSGKLNEIWHRRHDYWLLAGIV
LHGYARWQDIQNDAQFAIINEPFKTEANKGNFLEMKNKFLARRFKLLEQALVIEEQLRRAAYLNLSQEPAHPAMALHARFAEAECLAESH
QHLSKESLAGNKPANAVLHKVLNQLEELLSDMKADVTRLPATLSRIPPIAARLQMSERSILSRLASKGTEPHPTPAYPPGPYATPPGYGA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PPDPF-CHD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPDPF-CHD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPDPF-CHD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC4748701SNIJDERS BLOK-CAMPEAU SYNDROME2GENOMICS_ENGLAND;UNIPROT
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0036920Sezary Syndrome1CTD_human
TgeneC0221355Macrocephaly1GENOMICS_ENGLAND
TgeneC0376358Malignant neoplasm of prostate1CTD_human
TgeneC0557874Global developmental delay1GENOMICS_ENGLAND
TgeneC2931456Prostate cancer, familial1CTD_human
TgeneC3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneC4722327PROSTATE CANCER, HEREDITARY, 11CTD_human