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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CALCA-SFTPB (FusionGDB2 ID:HG796TG6439)

Fusion Gene Summary for CALCA-SFTPB

check button Fusion gene summary
Fusion gene informationFusion gene name: CALCA-SFTPB
Fusion gene ID: hg796tg6439
HgeneTgene
Gene symbol

CALCA

SFTPB

Gene ID

796

6439

Gene namecalcitonin related polypeptide alphasurfactant protein B
SynonymsCALC1|CGRP|CGRP-I|CGRP-alpha|CGRP1|CT|KC|PCTPSP-B|SFTB3|SFTP3|SMDP1|SP-B
Cytomap('CALCA')('SFTPB')

11p15.2

2p11.2

Type of geneprotein-codingprotein-coding
Descriptioncalcitonincalcitonin gene-related peptide 1alpha-type CGRPcalcitonin 1calcitonin gene-related peptide Icalcitonin/calcitonin-related polypeptide, alphakatacalcinpulmonary surfactant-associated protein B18 kDa pulmonary-surfactant protein6 kDa proteinpulmonary surfactant-associated proteolipid SPL(Phe)
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000359642, ENST00000331587, 
ENST00000361010, ENST00000396372, 
ENST00000486207, 
Fusion gene scores* DoF score2 X 2 X 2=813 X 12 X 2=312
# samples 215
** MAII scorelog2(2/8*10)=1.32192809488736log2(15/312*10)=-1.05658352836637
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CALCA [Title/Abstract] AND SFTPB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCALCA(14990372)-SFTPB(85885978), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCALCA

GO:0002548

monocyte chemotaxis

15248232

HgeneCALCA

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

8078488|11014233

HgeneCALCA

GO:0007204

positive regulation of cytosolic calcium ion concentration

17983652

HgeneCALCA

GO:0007566

embryo implantation

17983652

HgeneCALCA

GO:0032147

activation of protein kinase activity

17983652

HgeneCALCA

GO:0045779

negative regulation of bone resorption

17241109

HgeneCALCA

GO:0045892

negative regulation of transcription, DNA-templated

11014233

HgeneCALCA

GO:0051482

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

8078488



check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-MP-A4TE-01ACALCAchr11

14990372

-SFTPBchr2

85885978

-


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Fusion Gene ORF analysis for CALCA-SFTPB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000359642ENST00000342375CALCAchr11

14990372

-SFTPBchr2

85885978

-
5CDS-3UTRENST00000359642ENST00000393822CALCAchr11

14990372

-SFTPBchr2

85885978

-
5CDS-3UTRENST00000359642ENST00000409383CALCAchr11

14990372

-SFTPBchr2

85885978

-
5CDS-3UTRENST00000359642ENST00000519937CALCAchr11

14990372

-SFTPBchr2

85885978

-
intron-3UTRENST00000331587ENST00000342375CALCAchr11

14990372

-SFTPBchr2

85885978

-
intron-3UTRENST00000331587ENST00000393822CALCAchr11

14990372

-SFTPBchr2

85885978

-
intron-3UTRENST00000331587ENST00000409383CALCAchr11

14990372

-SFTPBchr2

85885978

-
intron-3UTRENST00000331587ENST00000519937CALCAchr11

14990372

-SFTPBchr2

85885978

-
intron-3UTRENST00000361010ENST00000342375CALCAchr11

14990372

-SFTPBchr2

85885978

-
intron-3UTRENST00000361010ENST00000393822CALCAchr11

14990372

-SFTPBchr2

85885978

-
intron-3UTRENST00000361010ENST00000409383CALCAchr11

14990372

-SFTPBchr2

85885978

-
intron-3UTRENST00000361010ENST00000519937CALCAchr11

14990372

-SFTPBchr2

85885978

-
intron-3UTRENST00000396372ENST00000342375CALCAchr11

14990372

-SFTPBchr2

85885978

-
intron-3UTRENST00000396372ENST00000393822CALCAchr11

14990372

-SFTPBchr2

85885978

-
intron-3UTRENST00000396372ENST00000409383CALCAchr11

14990372

-SFTPBchr2

85885978

-
intron-3UTRENST00000396372ENST00000519937CALCAchr11

14990372

-SFTPBchr2

85885978

-
intron-3UTRENST00000486207ENST00000342375CALCAchr11

14990372

-SFTPBchr2

85885978

-
intron-3UTRENST00000486207ENST00000393822CALCAchr11

14990372

-SFTPBchr2

85885978

-
intron-3UTRENST00000486207ENST00000409383CALCAchr11

14990372

-SFTPBchr2

85885978

-
intron-3UTRENST00000486207ENST00000519937CALCAchr11

14990372

-SFTPBchr2

85885978

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CALCA-SFTPB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for CALCA-SFTPB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:14990372/:85885978)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CALCA-SFTPB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CALCA-SFTPB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CALCA-SFTPB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CALCA-SFTPB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCALCAC0020429Hyperalgesia4CTD_human
HgeneCALCAC0458247Allodynia4CTD_human
HgeneCALCAC0751211Hyperalgesia, Primary4CTD_human
HgeneCALCAC0751212Hyperalgesia, Secondary4CTD_human
HgeneCALCAC0751213Tactile Allodynia4CTD_human
HgeneCALCAC0751214Hyperalgesia, Thermal4CTD_human
HgeneCALCAC2936719Mechanical Allodynia4CTD_human
HgeneCALCAC0007370Catalepsy3CTD_human
HgeneCALCAC0233612Waxy flexibility3CTD_human
HgeneCALCAC0007852Cervical Migraine Syndrome2CTD_human
HgeneCALCAC0018984Hemicrania migraine2CTD_human
HgeneCALCAC0020437Hypercalcemia2CTD_human
HgeneCALCAC0020538Hypertensive disease2CTD_human
HgeneCALCAC0026141Milk-Alkali Syndrome2CTD_human
HgeneCALCAC0085129Bronchial Hyperreactivity2CTD_human
HgeneCALCAC0149931Migraine Disorders2CTD_human
HgeneCALCAC0270858Abdominal Migraine2CTD_human
HgeneCALCAC0338480Common Migraine2CTD_human
HgeneCALCAC0338489Status Migrainosus2CTD_human
HgeneCALCAC0521664Acute Confusional Migraine2CTD_human
HgeneCALCAC0700438Sick Headaches2CTD_human
HgeneCALCAC0751217Hyperkinesia, Generalized2CTD_human
HgeneCALCAC3887506Hyperkinesia2CTD_human
HgeneCALCAC0003865Arthritis, Adjuvant-Induced1CTD_human
HgeneCALCAC0004352Autistic Disorder1CTD_human
HgeneCALCAC0013080Down Syndrome1CTD_human
HgeneCALCAC0013604Edema1CTD_human
HgeneCALCAC0020542Pulmonary Hypertension1CTD_human
HgeneCALCAC0020796Profound Mental Retardation1CTD_human
HgeneCALCAC0021368Inflammation1CTD_human
HgeneCALCAC0025363Mental Retardation, Psychosocial1CTD_human
HgeneCALCAC0029408Degenerative polyarthritis1CTD_human
HgeneCALCAC0033578Prostatic Neoplasms1CTD_human
HgeneCALCAC0034069Pulmonary Fibrosis1CTD_human
HgeneCALCAC0040997Trigeminal Neuralgia1CTD_human
HgeneCALCAC0086743Osteoarthrosis Deformans1CTD_human
HgeneCALCAC0149940Sciatic Neuropathy1CTD_human
HgeneCALCAC0151603Anasarca1CTD_human
HgeneCALCAC0154748Lesion of Sciatic Nerve1CTD_human
HgeneCALCAC0242013Sciatic Neuritis1CTD_human
HgeneCALCAC0344315Depressed mood1PSYGENET
HgeneCALCAC0376358Malignant neoplasm of prostate1CTD_human
HgeneCALCAC0393786Trigeminal Neuralgia, Idiopathic1CTD_human
HgeneCALCAC0393787Secondary Trigeminal Neuralgia1CTD_human
HgeneCALCAC0432416Down Syndrome, Partial Trisomy 211CTD_human
HgeneCALCAC0432417Trisomy 21, Meiotic Nondisjunction1CTD_human
HgeneCALCAC0600467Neurogenic Inflammation1CTD_human
HgeneCALCAC0751081Trisomy 21, Mitotic Nondisjunction1CTD_human
HgeneCALCAC0751924Neuralgia-Neuritis, Sciatic Nerve1CTD_human
HgeneCALCAC0751925Sciatic Nerve Palsy1CTD_human
HgeneCALCAC0917816Mental deficiency1CTD_human
HgeneCALCAC0971858Arthritis, Collagen-Induced1CTD_human
HgeneCALCAC0993582Arthritis, Experimental1CTD_human
HgeneCALCAC3714756Intellectual Disability1CTD_human
HgeneCALCAC4721507Alveolitis, Fibrosing1CTD_human
TgeneC1968602Surfactant Metabolism Dysfunction, Pulmonary, 14CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0019284Diaphragmatic Hernia2CTD_human
TgeneC0020192Hyaline Membrane Disease1ORPHANET
TgeneC0024115Lung diseases1CTD_human
TgeneC0024121Lung Neoplasms1CTD_human
TgeneC0035220Respiratory Distress Syndrome, Newborn1ORPHANET
TgeneC0242379Malignant neoplasm of lung1CTD_human
TgeneC0852283Respiratory Distress Syndrome1ORPHANET