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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:MZT2B-SOD2 (FusionGDB2 ID:HG80097TG6648)

Fusion Gene Summary for MZT2B-SOD2

check button Fusion gene summary
Fusion gene informationFusion gene name: MZT2B-SOD2
Fusion gene ID: hg80097tg6648
HgeneTgene
Gene symbol

MZT2B

SOD2

Gene ID

80097

6648

Gene namemitotic spindle organizing protein 2Bsuperoxide dismutase 2
SynonymsFAM128B|MOZART2BGClnc1|IPO-B|IPOB|MNSOD|MVCD6|Mn-SOD
Cytomap('MZT2B')('SOD2')

2q21.1

6q25.3

Type of geneprotein-codingprotein-coding
Descriptionmitotic-spindle organizing protein 2Bfamily with sequence similarity 128, member Bmitotic-spindle organizing protein associated with a ring of gamma-tubulin 2Bsuperoxide dismutase [Mn], mitochondrialMn superoxide dismutaseepididymis secretory sperm binding proteingastric cancer-associated lncRNA 1indophenoloxidase Bmanganese-containing superoxide dismutasemangano-superoxide dismutasesuperoxide dismutase
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000491178, ENST00000281871, 
ENST00000409255, 
Fusion gene scores* DoF score5 X 5 X 3=7513 X 22 X 6=1716
# samples 622
** MAII scorelog2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/1716*10)=-2.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MZT2B [Title/Abstract] AND SOD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMZT2B(130940348)-SOD2(160106065), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSOD2

GO:0006801

superoxide metabolic process

12551919|14980699

TgeneSOD2

GO:1904706

negative regulation of vascular smooth muscle cell proliferation

27021683

TgeneSOD2

GO:1905461

positive regulation of vascular associated smooth muscle cell apoptotic process

27021683

TgeneSOD2

GO:1905932

positive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching

27021683


check buttonFusion gene breakpoints across MZT2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SOD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-2A-A8VVMZT2Bchr2

130940348

+SOD2chr6

160106065

-


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Fusion Gene ORF analysis for MZT2B-SOD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000491178ENST00000367054MZT2Bchr2

130940348

+SOD2chr6

160106065

-
3UTR-3CDSENST00000491178ENST00000367055MZT2Bchr2

130940348

+SOD2chr6

160106065

-
3UTR-3CDSENST00000491178ENST00000538183MZT2Bchr2

130940348

+SOD2chr6

160106065

-
3UTR-3CDSENST00000491178ENST00000546087MZT2Bchr2

130940348

+SOD2chr6

160106065

-
3UTR-intronENST00000491178ENST00000337404MZT2Bchr2

130940348

+SOD2chr6

160106065

-
3UTR-intronENST00000491178ENST00000444946MZT2Bchr2

130940348

+SOD2chr6

160106065

-
3UTR-intronENST00000491178ENST00000452684MZT2Bchr2

130940348

+SOD2chr6

160106065

-
3UTR-intronENST00000491178ENST00000535372MZT2Bchr2

130940348

+SOD2chr6

160106065

-
5CDS-intronENST00000281871ENST00000337404MZT2Bchr2

130940348

+SOD2chr6

160106065

-
5CDS-intronENST00000281871ENST00000444946MZT2Bchr2

130940348

+SOD2chr6

160106065

-
5CDS-intronENST00000281871ENST00000452684MZT2Bchr2

130940348

+SOD2chr6

160106065

-
5CDS-intronENST00000281871ENST00000535372MZT2Bchr2

130940348

+SOD2chr6

160106065

-
5CDS-intronENST00000409255ENST00000337404MZT2Bchr2

130940348

+SOD2chr6

160106065

-
5CDS-intronENST00000409255ENST00000444946MZT2Bchr2

130940348

+SOD2chr6

160106065

-
5CDS-intronENST00000409255ENST00000452684MZT2Bchr2

130940348

+SOD2chr6

160106065

-
5CDS-intronENST00000409255ENST00000535372MZT2Bchr2

130940348

+SOD2chr6

160106065

-
In-frameENST00000281871ENST00000367054MZT2Bchr2

130940348

+SOD2chr6

160106065

-
In-frameENST00000281871ENST00000367055MZT2Bchr2

130940348

+SOD2chr6

160106065

-
In-frameENST00000281871ENST00000538183MZT2Bchr2

130940348

+SOD2chr6

160106065

-
In-frameENST00000281871ENST00000546087MZT2Bchr2

130940348

+SOD2chr6

160106065

-
In-frameENST00000409255ENST00000367054MZT2Bchr2

130940348

+SOD2chr6

160106065

-
In-frameENST00000409255ENST00000367055MZT2Bchr2

130940348

+SOD2chr6

160106065

-
In-frameENST00000409255ENST00000538183MZT2Bchr2

130940348

+SOD2chr6

160106065

-
In-frameENST00000409255ENST00000546087MZT2Bchr2

130940348

+SOD2chr6

160106065

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000281871MZT2Bchr2130940348+ENST00000546087SOD2chr6160106065-1199674355999214
ENST00000281871MZT2Bchr2130940348+ENST00000538183SOD2chr6160106065-144366747880263
ENST00000281871MZT2Bchr2130940348+ENST00000367055SOD2chr6160106065-12546747880263
ENST00000281871MZT2Bchr2130940348+ENST00000367054SOD2chr6160106065-1202674355999214
ENST00000409255MZT2Bchr2130940348+ENST00000546087SOD2chr6160106065-87034526670214
ENST00000409255MZT2Bchr2130940348+ENST00000538183SOD2chr6160106065-1410734526670214
ENST00000409255MZT2Bchr2130940348+ENST00000367055SOD2chr6160106065-92534526670214
ENST00000409255MZT2Bchr2130940348+ENST00000367054SOD2chr6160106065-87334526670214

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000281871ENST00000546087MZT2Bchr2130940348+SOD2chr6160106065-0.0039766180.9960234
ENST00000281871ENST00000538183MZT2Bchr2130940348+SOD2chr6160106065-0.0008835740.99911636
ENST00000281871ENST00000367055MZT2Bchr2130940348+SOD2chr6160106065-0.0033546790.9966453
ENST00000281871ENST00000367054MZT2Bchr2130940348+SOD2chr6160106065-0.0039353010.9960647
ENST00000409255ENST00000546087MZT2Bchr2130940348+SOD2chr6160106065-0.0014034540.9985965
ENST00000409255ENST00000538183MZT2Bchr2130940348+SOD2chr6160106065-0.0008588270.9991411
ENST00000409255ENST00000367055MZT2Bchr2130940348+SOD2chr6160106065-0.0011362270.9988638
ENST00000409255ENST00000367054MZT2Bchr2130940348+SOD2chr6160106065-0.0013862820.9986137

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Fusion Genomic Features for MZT2B-SOD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for MZT2B-SOD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:130940348/chr6:160106065)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MZT2B-SOD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>56892_56892_1_MZT2B-SOD2_MZT2B_chr2_130940348_ENST00000281871_SOD2_chr6_160106065_ENST00000367054_length(transcript)=1202nt_BP=674nt
TTTCTTGAAAGAGGCATTTACCGAGCGCCCAATGTATGCCTGGCACTGGGCTGGGTGCTGCCACCTAAGCGAGCACGACCAATGCAGTCT
ATCAGGGAGGCCCAGATCGCCAAGCAGCGGACCCCTGCGGTCCGCCATGCCACTCCCGGCTCCTAGAGCGCCGCTCAGCACACCGTGAGC
GCCCAATAACTGTTGGGCTTCAATGACGCCGCGGAGGCGGCCCCGTCCCCGCGCTCCCGCCCCTCCCGCCAGGGCAGCCCGGGAGGCCAG
ACGTTGACGCTGCAGGGAGAGGGTGGTGGGCGCAGCCGCTAGGGGGCGCGGCGGGGCGGAGCGCACCTTTCCGCGGGCCGCGGGGATGGC
GGCGCAGGGCGTAGGGCCTGGGCCGGGGTCGGCGGCGCCCCCGGGGCTGGAGGCGGCCCGGCAGAAGCTGGCGCTGCGGCGGAAGAAGGT
GCTGAGCACCGAGGAGATGGAGCTGTACGAGCTGGCGCAGGCGGCGGGCGGCGCTATCGACCCCGACGTGTTCAAGATCCTGGTGGACCT
GCTGAAGCTGAACGTGGCCCCCCTCGCCGTCTTCCAGATGCTCAAGTCCATGTGTGCCGGGCAGAGGCTAGCGAGCGAGCCCCAGGACCC
TGCGGCCGTGTCTCTGCCCACGTCGAGCGTGCCCGAGACCCGAGGGGAGTTGCTGGAAGCCATCAAACGTGACTTTGGTTCCTTTGACAA
GTTTAAGGAGAAGCTGACGGCTGCATCTGTTGGTGTCCAAGGCTCAGGTTGGGGTTGGCTTGGTTTCAATAAGGAACGGGGACACTTACA
AATTGCTGCTTGTCCAAATCAGGATCCACTGCAAGGAACAACAGGCCTTATTCCACTGCTGGGGATTGATGTGTGGGAGCACGCTTACTA
CCTTCAGTATAAAAATGTCAGGCCTGATTATCTAAAAGCTATTTGGAATGTAATCAACTGGGAGAATGTAACTGAAAGATACATGGCTTG
CAAAAAGTAAACCACGATCGTTATGCTGATCATACCCTAATGATCCCAGCAAGATAATGTCCTGTCTTCTAAGATGTGCATCAAGCCTGG
TACATACTGAAAACCCTATAAGGTCCTGGATAATTTTTGTTTGATTATTCATTGAAGAAACATTTATTTTCCAATTGTGTGAAGTTTTTG

>56892_56892_1_MZT2B-SOD2_MZT2B_chr2_130940348_ENST00000281871_SOD2_chr6_160106065_ENST00000367054_length(amino acids)=214AA_BP=101
MAAQGVGPGPGSAAPPGLEAARQKLALRRKKVLSTEEMELYELAQAAGGAIDPDVFKILVDLLKLNVAPLAVFQMLKSMCAGQRLASEPQ
DPAAVSLPTSSVPETRGELLEAIKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHA

--------------------------------------------------------------
>56892_56892_2_MZT2B-SOD2_MZT2B_chr2_130940348_ENST00000281871_SOD2_chr6_160106065_ENST00000367055_length(transcript)=1254nt_BP=674nt
TTTCTTGAAAGAGGCATTTACCGAGCGCCCAATGTATGCCTGGCACTGGGCTGGGTGCTGCCACCTAAGCGAGCACGACCAATGCAGTCT
ATCAGGGAGGCCCAGATCGCCAAGCAGCGGACCCCTGCGGTCCGCCATGCCACTCCCGGCTCCTAGAGCGCCGCTCAGCACACCGTGAGC
GCCCAATAACTGTTGGGCTTCAATGACGCCGCGGAGGCGGCCCCGTCCCCGCGCTCCCGCCCCTCCCGCCAGGGCAGCCCGGGAGGCCAG
ACGTTGACGCTGCAGGGAGAGGGTGGTGGGCGCAGCCGCTAGGGGGCGCGGCGGGGCGGAGCGCACCTTTCCGCGGGCCGCGGGGATGGC
GGCGCAGGGCGTAGGGCCTGGGCCGGGGTCGGCGGCGCCCCCGGGGCTGGAGGCGGCCCGGCAGAAGCTGGCGCTGCGGCGGAAGAAGGT
GCTGAGCACCGAGGAGATGGAGCTGTACGAGCTGGCGCAGGCGGCGGGCGGCGCTATCGACCCCGACGTGTTCAAGATCCTGGTGGACCT
GCTGAAGCTGAACGTGGCCCCCCTCGCCGTCTTCCAGATGCTCAAGTCCATGTGTGCCGGGCAGAGGCTAGCGAGCGAGCCCCAGGACCC
TGCGGCCGTGTCTCTGCCCACGTCGAGCGTGCCCGAGACCCGAGGGGAGTTGCTGGAAGCCATCAAACGTGACTTTGGTTCCTTTGACAA
GTTTAAGGAGAAGCTGACGGCTGCATCTGTTGGTGTCCAAGGCTCAGGTTGGGGTTGGCTTGGTTTCAATAAGGAACGGGGACACTTACA
AATTGCTGCTTGTCCAAATCAGGATCCACTGCAAGGAACAACAGGCCTTATTCCACTGCTGGGGATTGATGTGTGGGAGCACGCTTACTA
CCTTCAGTATAAAAATGTCAGGCCTGATTATCTAAAAGCTATTTGGAATGTAATCAACTGGGAGAATGTAACTGAAAGATACATGGCTTG
CAAAAAGTAAACCACGATCGTTATGCTGATCATACCCTAATGATCCCAGCAAGATAATGTCCTGTCTTCTAAGATGTGCATCAAGCCTGG
TACATACTGAAAACCCTATAAGGTCCTGGATAATTTTTGTTTGATTATTCATTGAAGAAACATTTATTTTCCAATTGTGTGAAGTTTTTG

>56892_56892_2_MZT2B-SOD2_MZT2B_chr2_130940348_ENST00000281871_SOD2_chr6_160106065_ENST00000367055_length(amino acids)=263AA_BP=1
MKPSQPQPEPWTPTDAAVSFSLNLSKEPKSRLMASSNSPRVSGTLDVGRDTAAGSWGSLASLCPAHMDLSIWKTARGATFSFSRSTRILN
TSGSIAPPAACASSYSSISSVLSTFFRRSASFCRAASSPGGAADPGPGPTPCAAIPAARGKVRSAPPRPLAAAPTTLSLQRQRLASRAAL

--------------------------------------------------------------
>56892_56892_3_MZT2B-SOD2_MZT2B_chr2_130940348_ENST00000281871_SOD2_chr6_160106065_ENST00000538183_length(transcript)=14436nt_BP=674nt
TTTCTTGAAAGAGGCATTTACCGAGCGCCCAATGTATGCCTGGCACTGGGCTGGGTGCTGCCACCTAAGCGAGCACGACCAATGCAGTCT
ATCAGGGAGGCCCAGATCGCCAAGCAGCGGACCCCTGCGGTCCGCCATGCCACTCCCGGCTCCTAGAGCGCCGCTCAGCACACCGTGAGC
GCCCAATAACTGTTGGGCTTCAATGACGCCGCGGAGGCGGCCCCGTCCCCGCGCTCCCGCCCCTCCCGCCAGGGCAGCCCGGGAGGCCAG
ACGTTGACGCTGCAGGGAGAGGGTGGTGGGCGCAGCCGCTAGGGGGCGCGGCGGGGCGGAGCGCACCTTTCCGCGGGCCGCGGGGATGGC
GGCGCAGGGCGTAGGGCCTGGGCCGGGGTCGGCGGCGCCCCCGGGGCTGGAGGCGGCCCGGCAGAAGCTGGCGCTGCGGCGGAAGAAGGT
GCTGAGCACCGAGGAGATGGAGCTGTACGAGCTGGCGCAGGCGGCGGGCGGCGCTATCGACCCCGACGTGTTCAAGATCCTGGTGGACCT
GCTGAAGCTGAACGTGGCCCCCCTCGCCGTCTTCCAGATGCTCAAGTCCATGTGTGCCGGGCAGAGGCTAGCGAGCGAGCCCCAGGACCC
TGCGGCCGTGTCTCTGCCCACGTCGAGCGTGCCCGAGACCCGAGGGGAGTTGCTGGAAGCCATCAAACGTGACTTTGGTTCCTTTGACAA
GTTTAAGGAGAAGCTGACGGCTGCATCTGTTGGTGTCCAAGGCTCAGGTTGGGGTTGGCTTGGTTTCAATAAGGAACGGGGACACTTACA
AATTGCTGCTTGTCCAAATCAGGATCCACTGCAAGGAACAACAGGCCTTATTCCACTGCTGGGGATTGATGTGTGGGAGCACGCTTACTA
CCTTCAGTATAAAAATGTCAGGCCTGATTATCTAAAAGCTATTTGGAATGTAATCAACTGGGAGAATGTAACTGAAAGATACATGGCTTG
CAAAAAGTAAACCACGATCGTTATGCTGAGTATGTTAAGCTCTTTATGACTGTTTTTGTAGTGGTATAGAGTACTGCAGAATACAGTAAG
CTGCTCTATTGTAGCATTTCTTGATGTTGCTTAGTCACTTATTTCATAAACAACTTAATGTTCTGAATAATTTCTTACTAAACATTTTGT
TATTGGGCAAGTGATTGAAAATAGTAAATGCTTTGTGTGATTGAATCTGATTGGACATTTTCTTCAGAGAGCTAAATTACAATTGTCATT
TATAAAACCATCAAAAATATTCCATCCATATACTTTGGGGACTTGTAGGGATGCCTTTCTAGTCCTATTCTATTGCAGTTATAGAAAATC
TAGTCTTTTGCCCCAGTTACTTAAAAATAAAATATTAACACTTTCCCAAGGGAAACACTCGGCTTTCTATAGAAAATTGCACTTTTTGTC
GAGTAATCCTCTGCAGTGATACTTCTGGTAGATGTCACCCAGTGGTTTTTGTTAGGTCAAATGTTCCTGTATAGTTTTTGCAAATAGAGC
TGTATACTGTTTAAATGTAGCAGGTGAACTGAACTGGGGTTTGCTCACCTGCACAGTAAAGGCAAACTTCAACAGCAAAACTGCAAAAAG
GTGGTTTTTGCAGTAGGAGAAAGGAGGATGTTTATTTGCAGGGCGCCAAGCAAGGAGAATTGGGCAGCTCATGCTTGAGACCCAATCTCC
ATGATGACCTACAAGCTAGAGTATTTAAAGGCAGTGGTAAATTTCAGGAAAGCAGAAGTTAAAGGCAAAATTGTAAATCAGTCGAGATCG
GGTGCCTTCAGGGTGGTATGGCTGTATACCAAAATTGTAAATCACTACATGAAGCTTATATATTGGTTTGGCCTGAAAGGTGAAGTGGGG
TAGGCAGGGGGCGGGCTTACAGGTTATGGTGGATTCAAAGACTCCCTGATTTGTGATTGGTTAAGGAAGCAAAGCTTTGTCTAAAAACTT
GGGGTCCGCAGAAAGGAACATTAAGGTCTGGCCAGGCCCCTCAGGAAGAAACTGAGAGCAAAGAATGGAGGTCAGAGTTTAGTCCCTGGT
GTTCCCCCTTATCTGACGTCTGTGTGAATCCATTTGGTGGGGGTCTGGGTTTCTGAAAAGTAGCTCAGGGGCACGTGTTAAGGATGTCTC
TAGGTGACTCTAACTTCCCTGGCTATTGTTTGAAACTGTTATGACCTTCTTGCTTATCAGCTTGCTGGTTTCCTTCTCGGGGCGAGCTGG
GTGCCTGGAGTTTTCGGTGAAGGAAACTCAAGATTCTCCTTTATTTCTGTGCTTGTGGGAATCCCCCTGGCACACCCCAAAGAGGGGTCC
CTGCTCCGTCTCACAGGGATCTTTTTGTATATTTGGCTTAGCATCATACATTTGCCATGTTGTTTCATCATCTGCCTAATTTACTGTTTT
TGAATATTTCATTTGTTTCTAATTGTTACTACAGATAATGCTGGGGTGAGCAACTCTGTGTACATAGGTTTATCTCCTATTGGAATATTT
TCTTTATATAGGCGTTTTTTTTTTTTCTTTTTTTTTGGAGACAGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCGACCGGAG
CTCACTGCAACCTCCACTTCCCGGGTTCAAGTGATTGTCCCACCTCAGCCTCCTGAATAGCTGGGATTACAGGTGCATGCTACCATGCCT
GGCTACTTTTTGTATTTTTAGCAGAGACAGGGTTTCACCATGTTGGCCAGGGTGGTCTCGAACTCCTGACCTCAAGTGATCCGTCTGGCT
CAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCACCTGGCCTATATAGGCTTTTTTCTTAAACCTATTTAGTAATGTTTTCC
CAAGTTTATTTTTTATTTTTAATTTTTTCCCCAAGTTTATTTTTCTATTTTTTTTTCATGGAAAAATGGGGTAACTTAGCAGTTTCAATA
TTGAAGACTGAAGTTTAAAAAAAATTTAAATTCAAGGTACTTTTAAAATTCAGTTAGAAAAGTAGGCTTTAAAAATTATTAGAGACAAGA
GTACCAAAGCGGTGTGTGTATGTGTGTGTGTGTATGCATGCTTGTGGATTGGAAAAACTTTGGAGACTGATTACTTTTCATTATATATGT
GTCACAGTGAAACAGCTTTTATGTGTCATGTAAGATTACTGCTTGCCTCTCTAAGGAAGGTCGTGACTGTTTAAATAGACGGGCAAGGTG
GAACCTTTTGAAAGATGAGCTTTTGAATATAAGTTGTCTGCTAGATCATGGTTTGTATTGAACTAACAAGGTTTGCAGATCTGCTGACTT
ATATAAAGCTTTTTGATTCCTACTAAGCTTTAAGATTTAAAAAATGTTCAATGTTGAAATTTCTGTGGGGCTCTATTTTTGCTTTGGCTT
TCTGGTGAGAGAGTGAGGAAGCATTCTTTCCTTCACTAAGTTTGTCTTTCTTGTCTTCTGGATAGATTGATTTTAAGAGACTAAGGGAAT
TTACAAACTAAAGATTTTAGTCATCTGGTGGAAAAGGAGACTTTAAGATTGTTTAGGGCTGGGCGGGGTGACTCACATCTGTAATCCCAG
CACTTTGGGAGGCCAAGGCAGGCAGAACACTTGAAGGAGTTCAAGACCAGCGTGGCCAACGTGGTGAAACCCTGTCTCTACTAAAAATAC
AAAAATTGTTTAGCTCTGTTTTTCATAATAGAAATAGAAAAGGTAAAATTGCTTTTCTTCTGAAAAGAACAAGTATTGTTCATCCAAGAA
GGGTTTTTGTGACTGAATCAGCAGTGCCTGCCCTAGTCATAGCTGTGCTTCAAAAACCTCAGCATGATTAGTGTTGGAGCAAAACAAGGA
AGCAAAGCAAATACTGTTTTTGAAATTCTATCTGTTGCTTGAACTATTTTGTAATAATTAAACTTTGATGTTGAGAAATCACAACTTTAT
TGTACACTTCATTGCAACTTGAAATTCATGGTCTTAAAGTGAGATTTGAATTTCTATTGAGCGCCTTTAAAAAAGTAATACCAAACCATA
AAGTTAAAATCTATGTATATTGAGTCATATCTAAAACCACGTATAAACATAAATTGTATTTCCTGTTTTAATTCCAGGGGAAGTACTGTT
TGGGAAAGCTATTATTAGGTAAATGTTTTACAAATTACTGTTTCTCACTTTCAGTCATACCCTAATGATCCCAGCAAGATAATGTCCTGT
CTTCTAAGATGTGCATCAAGCCTGGTACATACTGAAAACCCTATAAGGTCCTGGATAATTTTTGTTTGATTATTCATTGAAGAAACATTT
ATTTTCCAATTGTGTGAAGTTTTTGACTGTTAATAAAAGAATCTGTCAACCATCAAAGAGGTCTGCATTATGCTTGCATGTCAAAAACTT
TAAAAATCCTATAATCTTCTGTCATTTTCACTGAGTTTCCATGGGAAAGGAATAGTAAATAATGGGTAGTTGAAATATTACTCTTAAGAC
CAAGACCTGTATCTCCAGTCATATCTGTAATAACATCATCTGATAACCTAAAAGCATAGTATTAGGGATATACGACAAAACCAAAGTGTT
TTTGCTGTTGTCACATACCACTCAATACTTTTACACCAGGTTGTCCAGTGGACACCAGCTGGATGTCCTATAATTCAATTCTGACACTGT
CTACCTGGAATTGGAGTCAGATCCCACAGGTGGAGGGCTCAGCCCACAAGACTGCCCCCACTCCAGATACCAATCGCAAGTCCCTATACT
TCTGACTGGCTATAAAGTGGGGTTCCCGTGACCCTTTCCTTGGTTTTGATTTATTTGCTAGAGCAGCTCCCAGAACACAGAGAAACACTC
TACTTATGTTTACCCATTTTTAATTTTATTACTTTATTAAAACTACATATTGGTTACAATACTAATTTATTGTAAAGGATATTTCATTTA
TTTATTTTTTTATTTAGAGATGGAGTCTCACTGTGTCACCCAGGCTGGAGTGCGGTGGCACAGTCTCAACTCACTGCAACCTCCACCTCC
TGAGTTCAAGCGATTCTCATGCCTCAGCCTCCCAAGTAGCTGGGATTACAAGTGTGCACCACCATGCCCAGCTAATTTTTGTATTTTTAG
TAGAGATGGGGTTTCACTCTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGTCATCCACCCACCTCAGCCTCCCAAAGTGCTGAGA
TTACAGGTGTGAGCCATTGCCTCTGGCTTGTAAAGGATATTTCAAAGAATACAGATGAACAGCCAGATGGAAGAGATGCACAGGGCAAGG
CATGTGGGAAGGGGTATGGAGCTTTCATGCTCTCTCCACGTCATCAGCTACCCAGAAGCTCATCTGGACCCCGACCCTTTGGGGTTTTAC
GGAGGCTTCATTATGTCAGCATTACCATTGGCAATTGGCGATTAACTCAACCTTCAGCCTCTCTCCCCTTTCTGGAGGTTGGGGGTTGAG
GCTGGGAGTCCAAACCCTCCAATCTTGCCTTGGTCTTTCTGGTAAGCAGCCCCCCGTCCTGAAGCTACCTAGAGGCTCCCAGCCACCAAT
CATTTCATTGGCAAACCAAAGATACTTCAAGGGGTTTAGGAGCCAAGAGACCAAGCAAGGATTGAGACAATATATATATTTCTTATAAAT
AACATGATCACAAATAGTATTTTATATATTTCTCATAATAGCTGGTTGTGGTTACTCACACCTATCATCCCAGCTACTAAGAAGCTAAGG
CAGGAGGATCACAGGCCCAGGAGTTTGCAGCTGTAGTGAGCTATGATTGTGCTACTGCACTCCAGCCTGGGTGACAGTGTGAGACCCTGT
CTCTTAAAGTTCTTGTAACATCTTAGAACATTAACCAACCACAGATTATTGCCTTAACTCTGAAAAATAAAGTAATCATACTTTTACAAG
ATGTATTTTACATAAAGTTCTGGTGATATTTTACTCTGGTCATTGGAATATAGGAGCTTACCACCTGGTACCACTCTTCCTAAAGTGGTA
TACTATTTGGTATAGTACTGGCATACTATTTGGAAAGGGATGTGAAGTTGGCATGACCTGTCTAGGGTGAAGTCATGCTGTCTGCTATTC
ATTGTGGGCTTTACAGTAATGAGAGTGCTTCTGTTGTCAAGATGCTTCTGGGACACGTTAAAAAAAATTTAAGATTTCTCAGTTTGTGAA
AAGGAAGGAGCACGAATGCTTTCAAGTTCCTATGACATGCTAGTCATCTTTCAGTGTGTCCCATTGTTGCACCCAGTAGTCTCGATGCCC
AGCGTCACGGTGATTCCAAGTTTGCCTCTCTGCCCACTATAATTTGTGCTCCATGAAGTCCCAGGACATGAGGTTCTTGTTCATTTGTGC
GTCTGGGCCCATATCCAAATATTAAACAATGTGACTTAATGTATTTATCATATTGTAAATATGGGTATCCCCAAGGCTCAGAAGTTAACA
CAGCATATCCACAGAGAGGTTTGACAGCATGGCTGTGGTGACTGGGAAGGCCTTATGCTTGCTCCTCCTTCTGCTGCTTGCCTTTGTGTG
GGCATGGAAAGAACATTGAATTAGGTACTGGAAGACCTGGGTCCTGGTCTTGGAGATTTTACCAGAGCACCTGTGGGATATTGGTCAAGA
TGCCTGGTTTTAGTCCTGCTCCTTTGCTGTGAAAGAGGATCTTAAGGTGCCAACTCTGGCATTTTATTTTTTACTTATTTATTTTTAAAT
TATACTTTAAGTTCTAGGGTACATGTGTACAACATGCAGGTTTGTTACATGTATACATGTGCCATGTTGGTGTGCTGCACCTATTAACTC
GTCATTTACATTAGGTATATCTCCTAATGCTATCCCTCCCCCTTCTCCCCACCCCTCGACAGGCCCCGGTGTGTGATGTTCCCCTTCCTG
TGTCCAAGTGTTCTCATTGTTCAATTCCCATCTATGAGTGAGAACATGCGGTGTTTGTTTTTTTGTCCTTGGAATAGTTTGCTGAGAAGG
ATGGTTTCCAGCTTCATCCATGTCCCTATAAAGGACATGAACTCTTCCTTTTTTATGGCTGCATAGTATTCCATGGTGTATATGTGCCAC
ATCTTCTTAAACCAATCTATCATTGATGGACATTTGGGTTGGTTCCAAGTCTTTGCTATTGTGAACAGTGCCACAATAAATATACGTGTG
CATGTGTCTTTATAGCAGCATGATTTATAATCCTTTGGGTATATACCCAGTAATGGGATGGCTGGGTCAAATGGTATTTCTAGTTCTAGA
TCCCTGAGGAATCGCCACACTGTCTTCCACAATGGTTGAACTAGTTTACAGTCCCACCACCAGTGTAAAAGTGTTCCTATTTCTCCACAT
CCTCTCCAGCACCTGTTGTTTCCTGACTTTTTAATGATTGACATTCTAACTGGTGTGAGATGGTATCTCATTGTGGTTTTGATTTGCATT
TCTCTGATGGCCCATGATGATGAGCATTTTTTTCATGTGTCTGTTGGATGCATGGATGTCTTCTTTTGAGAAGTGTCTCTTCATATCCTT
CACCTACTTTTTGATGGGGTTTGTTTTTTTCTTGTAAGTTTGTTTGAGTTCCTTGTAGATTCTGGATATTAGCCCTTTGTCAGATGAGTA
GATTGCAAAAATTTTCTCCCATTTTGTAGGTTGCCTGTTCACTCTGATGGTAGTTTCTTTTGCTGTGCAGAAGCTCTTGAGTTTAATGAG
ATCCCATTTGTCAATTTTGGCTTCTGTTGCCATTGCTTTTGGTGTTTTAGACATGAAGTCCTTGCCCATGCCTGTGTCCTGAATGGTACT
GCATAGGTTTTCTTCTAGGGTTTTTATGGTTTTAGGTCTAACATTTAAGTCTTTAATCCATCTTGAATTAATTTTTGTATAAGGTGTAAG
GAAGGGATCCAGTTTCAGCTTTCTACATGTGGCTAGCCAGTTTTCCCAGCACCATTTATTAAATAGGGAATCCTTTCCCCATTTCTTGTT
TTTGTCAGGTTTCTCAAAGATCAGATAGTTGTAGATGTGTGGTATTATTTCTGAGGGCTCTGTTCTGTTCCATTGGTCTATATCTCTGTT
TTGGTACTAGTACCATGCTGTTTTGGTTACTGCAGCCTTGTAGTATAGTTTGAAATCAGGTAGCGTGATGCCTCCAGCTTTGTTCTTTTG
GCTTAGGATCGTTTTGGCAGTGCAGGCTCTTTTTTGGTTCCACATGAACTTTAAAGTAGTTTTTTCCAATTCTATGAAGAAAGTCATGGG
TAGCTTGATGGGGATGGCATTGAATCTATAAATTACCTTGGGCAGTATAGCCATTTTCACGATATTGATTCTTCCTATCCATGAGCATGG
AATGTTCTTCCATTTGTTTGTGTCCTCTTTTATTTCCTTGAGCAGTGGTTTGTAGTTCTCCTTGAAGAGGTCCTTCACATCCCTTGTAAG
TTGGATTCCTAGGTATTTTATTCTCTTTGAGGCAGTTGTGAATGGGAGTTCACTCATGATTTGGCTCTCTGTTTGTCTGTTGTTGGTGTA
TAAGAATGCTTGTGATTTTTGCACATTGATTTTGTATCCTGAGATTTTGCTGAAGTTGCTTATCAAATTAAGGAGATTTTGGGCTGAGAT
GATGGGGTTTTCTAAATATAAAATCATGTCATCTGCAAACAGGGACAATTTGACTTCCTCTTTTCCTTATTGAATACCCTTTATTTCTTT
CTCCTGCCTGATGGCCCTGGCCAGAACTTCCAACACTATGTTGAATAGGAGTGGTGAGAGAGGGCATCCCTGTCTTGTGCCAGTTTTCAA
AGGGAATGCTTCCAGTTTTTGCCCATTCAGTCTGATATTGGCTGTGGGTTTGTCATAGATAGCTCTTATTATTTTGAGATATGTCCCATC
AATACCTAATTCATTGAGAGTTTTTAGCATGAAGGGCTGTTGAATTTTGTCCAAGGCCTTTTCTGCATCTGTTGAGATAATCATGTGGTT
TTTGTCTTTGGTTCTGTTTATATGCTGGATTACTTTTATTGATTTGTGTATGTTGAACCAGCCTTGCATCCCAGGGATGAAGCCCACTTG
ATCATGGTGGATAAGCTTTTTGATATGCTGCTGGATTCAGTTTGCCAGTATTTTATTGAGGATTTTTGCATTGATTTTCATCAGGGATAT
TGGTCTAAAGTTCTCTTTTTTTGTTATGTCTCTGCCAGGCTTTGGTATCAGGATGATGCTGGCTTCATAAAATGAGTTAGGGAGGATTCC
CTCTTTTTCTATTGATTGGAATAGTTTCAGAAGGAATGGTACCAGCTCTTCCTTGTACCTCTGGTAGAATTCGGCTGTGAATCCATCTTG
TCCTGGACTTTTTTTGGTTGGTAGGCTATTAATTATTGCCTCAATTTCAGAGCCTGTTATTGGTCTATTCAGGGATTAAACTTCTTCCTG
GTTTAGTTTTGAGAGGGTGTATGTGTCCAGGAATTTATCTATTTCTTCTAGATTTTCTAGTTTATTTGCATAGAGGTGTTTATAGTATTC
TCTGTGTACTCTGTATTTCTGTGGGATTGGTGGTGATATCCACTTTATCATTTTTTATTGCATTTATTTGATTCTTCTCTCTTTTCTTGT
TTATTAGTCTTGCTAGCGGTCTATCAATTGTGTTTATCTTTTCAAAAAACCAGCTCCTGGATTCATTCATTTTTTGAAGGTTTTTTTGTG
TCTCTGTCTCCTTCAGTTCTGCTCTGATCTTAGTTATTTCTTGTCTTCTGCTAGCTGTTGAATGTGTTTGCTCTTGCTTCTCTAATATTT
TTAATTGTGATGTTAGAGTGTCAATTTTAGATCTTTCCTGCTTTCTCTTGTGGGCACTTAGTGCTGTAAATTTCCCTCTACACACTGCTT
TAAATGTGTCCCAGAGATTCTGGTATGTTGTGTCTTTGTTCTCGTTGGTTTCAAAGAACATCTTTATTTCTGCCTTCATTTTGTTATGTA
CCCAGTAGTCATTCAGGAGCAGGTTGTTCAGTTTCCATGTAGCTGAGTGGTTTTGAGTGAGTTTCTTAATCCTGAGTTCTAGTTTGATTG
CACTGTGGTCTGAGACAGTATGTTATAATTTCTGTTCTTTTACATTTGCTGAGGAGTGCTTTACTTCCAACTATGTGGTCAATTTTGGAA
TAGGTGCGATGTGGTGCTGAGAAGAATGTATATTCTGTTGATTTGGGGTGGAGAGTTCTGTAGATGTCTATTAGGTCTGCTTGGTGCAGA
GCTGAATTCAATTCCTGGATATCCTTGTTAACTTTCTGTCTCGTTGATCTGTCTAATATTGACAGTGGGGTGTTAGAGTCTCCCATTGTT
ATTGTGTGGGAGTCTAAATCTCTTTGTAGGTCTCTAAGGACTTGGTTTATGAATCTGGGTGCTCCTGTATTGGGTGCATATATATTTAAG
ATAGTTAGCTCTTCTTGTTGAATTGATCCCTTTACTATCATGTAATGGCCTTCTTTGTCTCTTTTGATCTTTGTTGGTTTAAAGTCTGTT
TTATCAGAGACTAGGATTGCAACCCCGGCCTTTTTTTTTGTTTTCCGTTTGCTTGGTAGATCTTCCTCCATCCTTTTATTTTGAGCCTAT
GTGTGTGTGTCTCTGTACGTGAGATGGGTTTCCTGAATACAGCACCCTGATGGGTCTTGACTCTTTATCCAGTGTGCCAGTCTGTGTCTT
TTAATTGGAGCATTTAGCCCATTTACATTTAAGGTTAATATTGTTATGTGTGAATTTGATCCTGTCACTAGGATGTTCACTGGTTATTTT
GCTCGTTAGTTGATGCAGTTTCTTCCTAGCCTCAATGGTCTTTACAATTTGGCATGTTTTTGCAGTGGCTGATACTGGTTGTTCCATTCC
ATGTTTAGTGCTTCCTTCAGGAGCTCTTGTAAGGCAGGCCTGGTGGTGACAAAATCTCTCAGCATTTGCTTGTTTGTAAAGGATTTTATT
TCTCCTTCACTTATGAAGCTTAGTTTGGCTGGATATGAAATTCTGGGTTGAAAATTCTTTTCTTCAAGAACGTTGAATATTGACCCCCAC
TCTCTTCTGGCTTGTAGAGTTTCTGCTGAGAGATCAGCTGTTAGTCTGATGGGCTTCCCTTTGTGGGTAACCCGACCTTTCTCTCTGGCT
GCCCTTAACATTTTTTCCTTCATTTCAACTTTGGTGAATCTGACAATTATGTGTCTTGGAGTTGCTCTTCTCGAGGAGTATCTTTGTGGC
GTTCTCTGTATTTCCTGAATTTGAATGTTGTCCTCCCTTGCTAGATTGGGGAAGTTCTCCTGGATAATATCCTGCAGAGTGTTTTCCAGC
TTGGTTCCATTCTCCCCGTCACTTTCAGGTACACCAATCAGACGTAGATTTGGTCTTTTCACATAGTCCCATATTTCTTGGAAGCTTTGT
TCGTTTCTTTTTACTCTTTTTTCTCTTAACTTCTCTTCTCACTTCATTTCATTCATCTGATCTTCAATCACTGATAACCTTTCTTCCAGT
TGATCGAATTGGCTACTGAAGCTTGTGCATTCGTCACGTAGTTCTCATGCCATGGTTTTCAGCTCCATCAGGTCATTTAAGGACTTCTCT
ATGCTGGTTATTCTAGTTAGCCATTTGTCTAATCTTTTTTCAAGGTTTTTAGGTTCTTTGTGATGGGTTCGAACTTCCTCTTTTAGCTTG
GAGAAGTTTGATCATCTGAAGCCTTCTTCTCTCAACTCGTCAAAGTCATTCTCCGTCCAGCTTTGTTCTGTTGCTGGCAAGGAGCTATGT
TCCTTTGGAGGGGGAGAGGCGCTCTGATTTTTAGAATTTTCAGCTTTTCTGCTCTGTTTTTTCCCCATCTTTGTGGTTTTATCTACCTTT
GGTCTTTGGTGATGGTGATGTGCAGATGGGGTTTTGGTGTGGATGTCCTTTCTGTTTGTTAGTTTTCCTTCTAACAGTCAGGACCGCCAG
CTGCAGGTCTGTTGGAGTTTGCTGGACGTCCACGCCAGACCCTGTTTGCCTGGGTATCACAGTGGAGGCTGTAGAACAGCGAATATTGCT
GAACAGCAAATGTTGCTGCCTGATCATTCCTCTGGAAGCTTCATCTCAGAGGGGTACCCGGCCATGTGGGGTGTCAGTCTGCCCCTACTT
GGGGGTGCCTCCCAGTTAGGCTACTCGGGGGTCAGGGACTCACTTGAGGAGGCAGTCTCTCCGTTCTCAGATCTCAAACTCTGTGCTGGG
AGAACCACTGGTCTCTTCAAAGCTGTCAGACAGGGACATTGAAGTCTGCAGAGATTTCTGCTGCCTTTTGTTCGGCTATGCCATGCCCCC
AGAGGTGGAGTCTACAGAGGCAGGCAGGCAGGCCTCCTTGAGCTGCAGTGGGCTCCACCTAGTTCGAGCTTCCCGGCTGCTTTATTTACC
TACTGAAGCCTCAGCAATGGTGGGCTCCCCTCCCCTAGCCTCACTGCCACCTTGCAGTTCGATCTCAGACTGCTGTGCTAGCAATGAGCA
AGGCTCCATGGGCGTGGGACCCTCCGAGCTAGGCACAGGATATAATCTCCTGGTGTGCCGTTTGCTAAGACCATTGGAAAAACGCAGTAT
TAGGGTGGGAGTGACCCAATTTTCCAGGTGCCGTCTGTCACAGCTTCCCTTGGCTAGGAAAGGGAATTCCCTGACCCCTTGCCTTCCCGG
GTGAGGCCATGCCTTGCCCTGCTTCAGCTCATGCTCAGTGGGCTGCACCCACCGTCCTACACCCACTGTCCAACAAGCCCCAGTGAGATG
AACCTGGTACCTCAGTTGGAAGTGCAGAAATCACCTGTCTTCTGCGTCGCTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGC
CATCTTGGAACCCAACCCAAGTCTGGCATTTTTTGGTTTTCTCTGTGTATTGACTATGATTATAGAGGATAAATGGATATTGATATTATT
AAATCGTCATTTACAGAAGGCACACAACTTATATCCTTTAAACAAAGTTCTCCAACCAGTAGGGTATACTTGCTGGTAGTGCTTACAGCT
GCCACCATTCTTCACTGGGGCTCAGAGTGGATGCCTGGAGGAAAAAAACAAATGAATCTTTTAGCTCCTAGTTACTGTTAGCATTTTTAC
CAGAAAACAATTTAAAAAATGACACAAGTAAGTCTTCACCTATCAAGGCTGAGTGTGGTGGCCTATACTTGTAATCTCTGTGCTTTGGGA
GGCCAACGCAGGAGGATCTCTTGAGTCCAGGAGTTTGAGACCAGCCTGGGCAACAAAGCAAGACCCCATCTCTACAGAAAGTTAAAATTT
AGCTGGGCATGCTGGCACATCCCTATAGTCCCAGCTACTTGAGAGGCTGAGTTGGGAGGATCCCTTGAGGTCATGAGTTGGAGTCTACAG
TGAGCTGTGATTACAGTGTGAGTCTACACTGCACTCCAGTCTGGGTGAAAGAGATCCTGTCTCTCAAAAAACAAGTGATTCTCCTGGGAA
GAGATTTGTTTAAAAAGTCTGCACCTCTATTGATGATAACTTTGAATGTAAATGGATTAAATTCTCCCACTTAAAAGATATAGATTGACT
GAATGGATTAAAAACCACCATCATGACTCGACTGTATGCTGCCTACAAGAAACCTCACCTGTAAAGACAGGCCAAAAGTGAAGGTATGGA
GAAAGATATTGCATACAAATGGAAGCCAAAAAAGAGCAGAAATAACTATACTTACATGAGATAAAATAGACTTTAAGTCAAAAACTGTAA
AAAGAAAAGTCATTATGTAATGAAACAAGGATCAATTCATGCAAGATATAATCATATTTTTTTATTAAGAAAATTTTTTTGTAGAGATGG
GGTTATGCTATGTTGCCTGGCTAGTCTCAAACTCTGGGTCTCAAAGCAGTCCTCCTGCTTTGGCCTCCTAAGGTGCTGGGATTATAGGCA
TGAGCCACTGTGCCAGGCCTGAGGATATTATCATTATAAATATATATGTACCCCACACTGGATGACCCAGATATAAAGCAAATATTATTA
GATTTAAAGGGAGAAATAGACTCTAATACAATAGTAGTTGAGGACTTCACTCTACTCTCAGCATTGGACAGATTTTCTAGACATAAAACC
AATAAATATTGGATTTAAATTGCACTTTACACCAAATGGACCTGACATTTACAGAACATTCTAATAGGTGCAGAACACTCTAATAGCTGC
AGAACACACGTTCTTTTCATCAGCACATGGAACATTCACCAGACTAGTTCTGGAACCCACTTCCTGCCTTAGTGTTCTTTCCACCACAGT
GCATGATAATTCCGACAGAACGCCTTTTATTTGTACCTTATTAGTTGTAGGGGGAAAGCTTTTTCATGTACAAAAATGCTGTAATTTTCT

>56892_56892_3_MZT2B-SOD2_MZT2B_chr2_130940348_ENST00000281871_SOD2_chr6_160106065_ENST00000538183_length(amino acids)=263AA_BP=1
MKPSQPQPEPWTPTDAAVSFSLNLSKEPKSRLMASSNSPRVSGTLDVGRDTAAGSWGSLASLCPAHMDLSIWKTARGATFSFSRSTRILN
TSGSIAPPAACASSYSSISSVLSTFFRRSASFCRAASSPGGAADPGPGPTPCAAIPAARGKVRSAPPRPLAAAPTTLSLQRQRLASRAAL

--------------------------------------------------------------
>56892_56892_4_MZT2B-SOD2_MZT2B_chr2_130940348_ENST00000281871_SOD2_chr6_160106065_ENST00000546087_length(transcript)=1199nt_BP=674nt
TTTCTTGAAAGAGGCATTTACCGAGCGCCCAATGTATGCCTGGCACTGGGCTGGGTGCTGCCACCTAAGCGAGCACGACCAATGCAGTCT
ATCAGGGAGGCCCAGATCGCCAAGCAGCGGACCCCTGCGGTCCGCCATGCCACTCCCGGCTCCTAGAGCGCCGCTCAGCACACCGTGAGC
GCCCAATAACTGTTGGGCTTCAATGACGCCGCGGAGGCGGCCCCGTCCCCGCGCTCCCGCCCCTCCCGCCAGGGCAGCCCGGGAGGCCAG
ACGTTGACGCTGCAGGGAGAGGGTGGTGGGCGCAGCCGCTAGGGGGCGCGGCGGGGCGGAGCGCACCTTTCCGCGGGCCGCGGGGATGGC
GGCGCAGGGCGTAGGGCCTGGGCCGGGGTCGGCGGCGCCCCCGGGGCTGGAGGCGGCCCGGCAGAAGCTGGCGCTGCGGCGGAAGAAGGT
GCTGAGCACCGAGGAGATGGAGCTGTACGAGCTGGCGCAGGCGGCGGGCGGCGCTATCGACCCCGACGTGTTCAAGATCCTGGTGGACCT
GCTGAAGCTGAACGTGGCCCCCCTCGCCGTCTTCCAGATGCTCAAGTCCATGTGTGCCGGGCAGAGGCTAGCGAGCGAGCCCCAGGACCC
TGCGGCCGTGTCTCTGCCCACGTCGAGCGTGCCCGAGACCCGAGGGGAGTTGCTGGAAGCCATCAAACGTGACTTTGGTTCCTTTGACAA
GTTTAAGGAGAAGCTGACGGCTGCATCTGTTGGTGTCCAAGGCTCAGGTTGGGGTTGGCTTGGTTTCAATAAGGAACGGGGACACTTACA
AATTGCTGCTTGTCCAAATCAGGATCCACTGCAAGGAACAACAGGCCTTATTCCACTGCTGGGGATTGATGTGTGGGAGCACGCTTACTA
CCTTCAGTATAAAAATGTCAGGCCTGATTATCTAAAAGCTATTTGGAATGTAATCAACTGGGAGAATGTAACTGAAAGATACATGGCTTG
CAAAAAGTAAACCACGATCGTTATGCTGATCATACCCTAATGATCCCAGCAAGATAATGTCCTGTCTTCTAAGATGTGCATCAAGCCTGG
TACATACTGAAAACCCTATAAGGTCCTGGATAATTTTTGTTTGATTATTCATTGAAGAAACATTTATTTTCCAATTGTGTGAAGTTTTTG

>56892_56892_4_MZT2B-SOD2_MZT2B_chr2_130940348_ENST00000281871_SOD2_chr6_160106065_ENST00000546087_length(amino acids)=214AA_BP=101
MAAQGVGPGPGSAAPPGLEAARQKLALRRKKVLSTEEMELYELAQAAGGAIDPDVFKILVDLLKLNVAPLAVFQMLKSMCAGQRLASEPQ
DPAAVSLPTSSVPETRGELLEAIKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHA

--------------------------------------------------------------
>56892_56892_5_MZT2B-SOD2_MZT2B_chr2_130940348_ENST00000409255_SOD2_chr6_160106065_ENST00000367054_length(transcript)=873nt_BP=345nt
AGCGCACCTTTCCGCGGGCCGCGGGGATGGCGGCGCAGGGCGTAGGGCCTGGGCCGGGGTCGGCGGCGCCCCCGGGGCTGGAGGCGGCCC
GGCAGAAGCTGGCGCTGCGGCGGAAGAAGGTGCTGAGCACCGAGGAGATGGAGCTGTACGAGCTGGCGCAGGCGGCGGGCGGCGCTATCG
ACCCCGACGTGTTCAAGATCCTGGTGGACCTGCTGAAGCTGAACGTGGCCCCCCTCGCCGTCTTCCAGATGCTCAAGTCCATGTGTGCCG
GGCAGAGGCTAGCGAGCGAGCCCCAGGACCCTGCGGCCGTGTCTCTGCCCACGTCGAGCGTGCCCGAGACCCGAGGGGAGTTGCTGGAAG
CCATCAAACGTGACTTTGGTTCCTTTGACAAGTTTAAGGAGAAGCTGACGGCTGCATCTGTTGGTGTCCAAGGCTCAGGTTGGGGTTGGC
TTGGTTTCAATAAGGAACGGGGACACTTACAAATTGCTGCTTGTCCAAATCAGGATCCACTGCAAGGAACAACAGGCCTTATTCCACTGC
TGGGGATTGATGTGTGGGAGCACGCTTACTACCTTCAGTATAAAAATGTCAGGCCTGATTATCTAAAAGCTATTTGGAATGTAATCAACT
GGGAGAATGTAACTGAAAGATACATGGCTTGCAAAAAGTAAACCACGATCGTTATGCTGATCATACCCTAATGATCCCAGCAAGATAATG
TCCTGTCTTCTAAGATGTGCATCAAGCCTGGTACATACTGAAAACCCTATAAGGTCCTGGATAATTTTTGTTTGATTATTCATTGAAGAA

>56892_56892_5_MZT2B-SOD2_MZT2B_chr2_130940348_ENST00000409255_SOD2_chr6_160106065_ENST00000367054_length(amino acids)=214AA_BP=101
MAAQGVGPGPGSAAPPGLEAARQKLALRRKKVLSTEEMELYELAQAAGGAIDPDVFKILVDLLKLNVAPLAVFQMLKSMCAGQRLASEPQ
DPAAVSLPTSSVPETRGELLEAIKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHA

--------------------------------------------------------------
>56892_56892_6_MZT2B-SOD2_MZT2B_chr2_130940348_ENST00000409255_SOD2_chr6_160106065_ENST00000367055_length(transcript)=925nt_BP=345nt
AGCGCACCTTTCCGCGGGCCGCGGGGATGGCGGCGCAGGGCGTAGGGCCTGGGCCGGGGTCGGCGGCGCCCCCGGGGCTGGAGGCGGCCC
GGCAGAAGCTGGCGCTGCGGCGGAAGAAGGTGCTGAGCACCGAGGAGATGGAGCTGTACGAGCTGGCGCAGGCGGCGGGCGGCGCTATCG
ACCCCGACGTGTTCAAGATCCTGGTGGACCTGCTGAAGCTGAACGTGGCCCCCCTCGCCGTCTTCCAGATGCTCAAGTCCATGTGTGCCG
GGCAGAGGCTAGCGAGCGAGCCCCAGGACCCTGCGGCCGTGTCTCTGCCCACGTCGAGCGTGCCCGAGACCCGAGGGGAGTTGCTGGAAG
CCATCAAACGTGACTTTGGTTCCTTTGACAAGTTTAAGGAGAAGCTGACGGCTGCATCTGTTGGTGTCCAAGGCTCAGGTTGGGGTTGGC
TTGGTTTCAATAAGGAACGGGGACACTTACAAATTGCTGCTTGTCCAAATCAGGATCCACTGCAAGGAACAACAGGCCTTATTCCACTGC
TGGGGATTGATGTGTGGGAGCACGCTTACTACCTTCAGTATAAAAATGTCAGGCCTGATTATCTAAAAGCTATTTGGAATGTAATCAACT
GGGAGAATGTAACTGAAAGATACATGGCTTGCAAAAAGTAAACCACGATCGTTATGCTGATCATACCCTAATGATCCCAGCAAGATAATG
TCCTGTCTTCTAAGATGTGCATCAAGCCTGGTACATACTGAAAACCCTATAAGGTCCTGGATAATTTTTGTTTGATTATTCATTGAAGAA
ACATTTATTTTCCAATTGTGTGAAGTTTTTGACTGTTAATAAAAGAATCTGTCAACCATCAAAGAGGTCTGCATTATGCTTGCATGTCAA

>56892_56892_6_MZT2B-SOD2_MZT2B_chr2_130940348_ENST00000409255_SOD2_chr6_160106065_ENST00000367055_length(amino acids)=214AA_BP=101
MAAQGVGPGPGSAAPPGLEAARQKLALRRKKVLSTEEMELYELAQAAGGAIDPDVFKILVDLLKLNVAPLAVFQMLKSMCAGQRLASEPQ
DPAAVSLPTSSVPETRGELLEAIKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHA

--------------------------------------------------------------
>56892_56892_7_MZT2B-SOD2_MZT2B_chr2_130940348_ENST00000409255_SOD2_chr6_160106065_ENST00000538183_length(transcript)=14107nt_BP=345nt
AGCGCACCTTTCCGCGGGCCGCGGGGATGGCGGCGCAGGGCGTAGGGCCTGGGCCGGGGTCGGCGGCGCCCCCGGGGCTGGAGGCGGCCC
GGCAGAAGCTGGCGCTGCGGCGGAAGAAGGTGCTGAGCACCGAGGAGATGGAGCTGTACGAGCTGGCGCAGGCGGCGGGCGGCGCTATCG
ACCCCGACGTGTTCAAGATCCTGGTGGACCTGCTGAAGCTGAACGTGGCCCCCCTCGCCGTCTTCCAGATGCTCAAGTCCATGTGTGCCG
GGCAGAGGCTAGCGAGCGAGCCCCAGGACCCTGCGGCCGTGTCTCTGCCCACGTCGAGCGTGCCCGAGACCCGAGGGGAGTTGCTGGAAG
CCATCAAACGTGACTTTGGTTCCTTTGACAAGTTTAAGGAGAAGCTGACGGCTGCATCTGTTGGTGTCCAAGGCTCAGGTTGGGGTTGGC
TTGGTTTCAATAAGGAACGGGGACACTTACAAATTGCTGCTTGTCCAAATCAGGATCCACTGCAAGGAACAACAGGCCTTATTCCACTGC
TGGGGATTGATGTGTGGGAGCACGCTTACTACCTTCAGTATAAAAATGTCAGGCCTGATTATCTAAAAGCTATTTGGAATGTAATCAACT
GGGAGAATGTAACTGAAAGATACATGGCTTGCAAAAAGTAAACCACGATCGTTATGCTGAGTATGTTAAGCTCTTTATGACTGTTTTTGT
AGTGGTATAGAGTACTGCAGAATACAGTAAGCTGCTCTATTGTAGCATTTCTTGATGTTGCTTAGTCACTTATTTCATAAACAACTTAAT
GTTCTGAATAATTTCTTACTAAACATTTTGTTATTGGGCAAGTGATTGAAAATAGTAAATGCTTTGTGTGATTGAATCTGATTGGACATT
TTCTTCAGAGAGCTAAATTACAATTGTCATTTATAAAACCATCAAAAATATTCCATCCATATACTTTGGGGACTTGTAGGGATGCCTTTC
TAGTCCTATTCTATTGCAGTTATAGAAAATCTAGTCTTTTGCCCCAGTTACTTAAAAATAAAATATTAACACTTTCCCAAGGGAAACACT
CGGCTTTCTATAGAAAATTGCACTTTTTGTCGAGTAATCCTCTGCAGTGATACTTCTGGTAGATGTCACCCAGTGGTTTTTGTTAGGTCA
AATGTTCCTGTATAGTTTTTGCAAATAGAGCTGTATACTGTTTAAATGTAGCAGGTGAACTGAACTGGGGTTTGCTCACCTGCACAGTAA
AGGCAAACTTCAACAGCAAAACTGCAAAAAGGTGGTTTTTGCAGTAGGAGAAAGGAGGATGTTTATTTGCAGGGCGCCAAGCAAGGAGAA
TTGGGCAGCTCATGCTTGAGACCCAATCTCCATGATGACCTACAAGCTAGAGTATTTAAAGGCAGTGGTAAATTTCAGGAAAGCAGAAGT
TAAAGGCAAAATTGTAAATCAGTCGAGATCGGGTGCCTTCAGGGTGGTATGGCTGTATACCAAAATTGTAAATCACTACATGAAGCTTAT
ATATTGGTTTGGCCTGAAAGGTGAAGTGGGGTAGGCAGGGGGCGGGCTTACAGGTTATGGTGGATTCAAAGACTCCCTGATTTGTGATTG
GTTAAGGAAGCAAAGCTTTGTCTAAAAACTTGGGGTCCGCAGAAAGGAACATTAAGGTCTGGCCAGGCCCCTCAGGAAGAAACTGAGAGC
AAAGAATGGAGGTCAGAGTTTAGTCCCTGGTGTTCCCCCTTATCTGACGTCTGTGTGAATCCATTTGGTGGGGGTCTGGGTTTCTGAAAA
GTAGCTCAGGGGCACGTGTTAAGGATGTCTCTAGGTGACTCTAACTTCCCTGGCTATTGTTTGAAACTGTTATGACCTTCTTGCTTATCA
GCTTGCTGGTTTCCTTCTCGGGGCGAGCTGGGTGCCTGGAGTTTTCGGTGAAGGAAACTCAAGATTCTCCTTTATTTCTGTGCTTGTGGG
AATCCCCCTGGCACACCCCAAAGAGGGGTCCCTGCTCCGTCTCACAGGGATCTTTTTGTATATTTGGCTTAGCATCATACATTTGCCATG
TTGTTTCATCATCTGCCTAATTTACTGTTTTTGAATATTTCATTTGTTTCTAATTGTTACTACAGATAATGCTGGGGTGAGCAACTCTGT
GTACATAGGTTTATCTCCTATTGGAATATTTTCTTTATATAGGCGTTTTTTTTTTTTCTTTTTTTTTGGAGACAGAGTCTTGCTCTGTTG
CCCAGGCTGGAGTGCAGTGGCGCGACCGGAGCTCACTGCAACCTCCACTTCCCGGGTTCAAGTGATTGTCCCACCTCAGCCTCCTGAATA
GCTGGGATTACAGGTGCATGCTACCATGCCTGGCTACTTTTTGTATTTTTAGCAGAGACAGGGTTTCACCATGTTGGCCAGGGTGGTCTC
GAACTCCTGACCTCAAGTGATCCGTCTGGCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCACCTGGCCTATATAGGCT
TTTTTCTTAAACCTATTTAGTAATGTTTTCCCAAGTTTATTTTTTATTTTTAATTTTTTCCCCAAGTTTATTTTTCTATTTTTTTTTCAT
GGAAAAATGGGGTAACTTAGCAGTTTCAATATTGAAGACTGAAGTTTAAAAAAAATTTAAATTCAAGGTACTTTTAAAATTCAGTTAGAA
AAGTAGGCTTTAAAAATTATTAGAGACAAGAGTACCAAAGCGGTGTGTGTATGTGTGTGTGTGTATGCATGCTTGTGGATTGGAAAAACT
TTGGAGACTGATTACTTTTCATTATATATGTGTCACAGTGAAACAGCTTTTATGTGTCATGTAAGATTACTGCTTGCCTCTCTAAGGAAG
GTCGTGACTGTTTAAATAGACGGGCAAGGTGGAACCTTTTGAAAGATGAGCTTTTGAATATAAGTTGTCTGCTAGATCATGGTTTGTATT
GAACTAACAAGGTTTGCAGATCTGCTGACTTATATAAAGCTTTTTGATTCCTACTAAGCTTTAAGATTTAAAAAATGTTCAATGTTGAAA
TTTCTGTGGGGCTCTATTTTTGCTTTGGCTTTCTGGTGAGAGAGTGAGGAAGCATTCTTTCCTTCACTAAGTTTGTCTTTCTTGTCTTCT
GGATAGATTGATTTTAAGAGACTAAGGGAATTTACAAACTAAAGATTTTAGTCATCTGGTGGAAAAGGAGACTTTAAGATTGTTTAGGGC
TGGGCGGGGTGACTCACATCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGAACACTTGAAGGAGTTCAAGACCAGCGTGGCCAA
CGTGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTGTTTAGCTCTGTTTTTCATAATAGAAATAGAAAAGGTAAAATTGCTTTTCTT
CTGAAAAGAACAAGTATTGTTCATCCAAGAAGGGTTTTTGTGACTGAATCAGCAGTGCCTGCCCTAGTCATAGCTGTGCTTCAAAAACCT
CAGCATGATTAGTGTTGGAGCAAAACAAGGAAGCAAAGCAAATACTGTTTTTGAAATTCTATCTGTTGCTTGAACTATTTTGTAATAATT
AAACTTTGATGTTGAGAAATCACAACTTTATTGTACACTTCATTGCAACTTGAAATTCATGGTCTTAAAGTGAGATTTGAATTTCTATTG
AGCGCCTTTAAAAAAGTAATACCAAACCATAAAGTTAAAATCTATGTATATTGAGTCATATCTAAAACCACGTATAAACATAAATTGTAT
TTCCTGTTTTAATTCCAGGGGAAGTACTGTTTGGGAAAGCTATTATTAGGTAAATGTTTTACAAATTACTGTTTCTCACTTTCAGTCATA
CCCTAATGATCCCAGCAAGATAATGTCCTGTCTTCTAAGATGTGCATCAAGCCTGGTACATACTGAAAACCCTATAAGGTCCTGGATAAT
TTTTGTTTGATTATTCATTGAAGAAACATTTATTTTCCAATTGTGTGAAGTTTTTGACTGTTAATAAAAGAATCTGTCAACCATCAAAGA
GGTCTGCATTATGCTTGCATGTCAAAAACTTTAAAAATCCTATAATCTTCTGTCATTTTCACTGAGTTTCCATGGGAAAGGAATAGTAAA
TAATGGGTAGTTGAAATATTACTCTTAAGACCAAGACCTGTATCTCCAGTCATATCTGTAATAACATCATCTGATAACCTAAAAGCATAG
TATTAGGGATATACGACAAAACCAAAGTGTTTTTGCTGTTGTCACATACCACTCAATACTTTTACACCAGGTTGTCCAGTGGACACCAGC
TGGATGTCCTATAATTCAATTCTGACACTGTCTACCTGGAATTGGAGTCAGATCCCACAGGTGGAGGGCTCAGCCCACAAGACTGCCCCC
ACTCCAGATACCAATCGCAAGTCCCTATACTTCTGACTGGCTATAAAGTGGGGTTCCCGTGACCCTTTCCTTGGTTTTGATTTATTTGCT
AGAGCAGCTCCCAGAACACAGAGAAACACTCTACTTATGTTTACCCATTTTTAATTTTATTACTTTATTAAAACTACATATTGGTTACAA
TACTAATTTATTGTAAAGGATATTTCATTTATTTATTTTTTTATTTAGAGATGGAGTCTCACTGTGTCACCCAGGCTGGAGTGCGGTGGC
ACAGTCTCAACTCACTGCAACCTCCACCTCCTGAGTTCAAGCGATTCTCATGCCTCAGCCTCCCAAGTAGCTGGGATTACAAGTGTGCAC
CACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACTCTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGTCAT
CCACCCACCTCAGCCTCCCAAAGTGCTGAGATTACAGGTGTGAGCCATTGCCTCTGGCTTGTAAAGGATATTTCAAAGAATACAGATGAA
CAGCCAGATGGAAGAGATGCACAGGGCAAGGCATGTGGGAAGGGGTATGGAGCTTTCATGCTCTCTCCACGTCATCAGCTACCCAGAAGC
TCATCTGGACCCCGACCCTTTGGGGTTTTACGGAGGCTTCATTATGTCAGCATTACCATTGGCAATTGGCGATTAACTCAACCTTCAGCC
TCTCTCCCCTTTCTGGAGGTTGGGGGTTGAGGCTGGGAGTCCAAACCCTCCAATCTTGCCTTGGTCTTTCTGGTAAGCAGCCCCCCGTCC
TGAAGCTACCTAGAGGCTCCCAGCCACCAATCATTTCATTGGCAAACCAAAGATACTTCAAGGGGTTTAGGAGCCAAGAGACCAAGCAAG
GATTGAGACAATATATATATTTCTTATAAATAACATGATCACAAATAGTATTTTATATATTTCTCATAATAGCTGGTTGTGGTTACTCAC
ACCTATCATCCCAGCTACTAAGAAGCTAAGGCAGGAGGATCACAGGCCCAGGAGTTTGCAGCTGTAGTGAGCTATGATTGTGCTACTGCA
CTCCAGCCTGGGTGACAGTGTGAGACCCTGTCTCTTAAAGTTCTTGTAACATCTTAGAACATTAACCAACCACAGATTATTGCCTTAACT
CTGAAAAATAAAGTAATCATACTTTTACAAGATGTATTTTACATAAAGTTCTGGTGATATTTTACTCTGGTCATTGGAATATAGGAGCTT
ACCACCTGGTACCACTCTTCCTAAAGTGGTATACTATTTGGTATAGTACTGGCATACTATTTGGAAAGGGATGTGAAGTTGGCATGACCT
GTCTAGGGTGAAGTCATGCTGTCTGCTATTCATTGTGGGCTTTACAGTAATGAGAGTGCTTCTGTTGTCAAGATGCTTCTGGGACACGTT
AAAAAAAATTTAAGATTTCTCAGTTTGTGAAAAGGAAGGAGCACGAATGCTTTCAAGTTCCTATGACATGCTAGTCATCTTTCAGTGTGT
CCCATTGTTGCACCCAGTAGTCTCGATGCCCAGCGTCACGGTGATTCCAAGTTTGCCTCTCTGCCCACTATAATTTGTGCTCCATGAAGT
CCCAGGACATGAGGTTCTTGTTCATTTGTGCGTCTGGGCCCATATCCAAATATTAAACAATGTGACTTAATGTATTTATCATATTGTAAA
TATGGGTATCCCCAAGGCTCAGAAGTTAACACAGCATATCCACAGAGAGGTTTGACAGCATGGCTGTGGTGACTGGGAAGGCCTTATGCT
TGCTCCTCCTTCTGCTGCTTGCCTTTGTGTGGGCATGGAAAGAACATTGAATTAGGTACTGGAAGACCTGGGTCCTGGTCTTGGAGATTT
TACCAGAGCACCTGTGGGATATTGGTCAAGATGCCTGGTTTTAGTCCTGCTCCTTTGCTGTGAAAGAGGATCTTAAGGTGCCAACTCTGG
CATTTTATTTTTTACTTATTTATTTTTAAATTATACTTTAAGTTCTAGGGTACATGTGTACAACATGCAGGTTTGTTACATGTATACATG
TGCCATGTTGGTGTGCTGCACCTATTAACTCGTCATTTACATTAGGTATATCTCCTAATGCTATCCCTCCCCCTTCTCCCCACCCCTCGA
CAGGCCCCGGTGTGTGATGTTCCCCTTCCTGTGTCCAAGTGTTCTCATTGTTCAATTCCCATCTATGAGTGAGAACATGCGGTGTTTGTT
TTTTTGTCCTTGGAATAGTTTGCTGAGAAGGATGGTTTCCAGCTTCATCCATGTCCCTATAAAGGACATGAACTCTTCCTTTTTTATGGC
TGCATAGTATTCCATGGTGTATATGTGCCACATCTTCTTAAACCAATCTATCATTGATGGACATTTGGGTTGGTTCCAAGTCTTTGCTAT
TGTGAACAGTGCCACAATAAATATACGTGTGCATGTGTCTTTATAGCAGCATGATTTATAATCCTTTGGGTATATACCCAGTAATGGGAT
GGCTGGGTCAAATGGTATTTCTAGTTCTAGATCCCTGAGGAATCGCCACACTGTCTTCCACAATGGTTGAACTAGTTTACAGTCCCACCA
CCAGTGTAAAAGTGTTCCTATTTCTCCACATCCTCTCCAGCACCTGTTGTTTCCTGACTTTTTAATGATTGACATTCTAACTGGTGTGAG
ATGGTATCTCATTGTGGTTTTGATTTGCATTTCTCTGATGGCCCATGATGATGAGCATTTTTTTCATGTGTCTGTTGGATGCATGGATGT
CTTCTTTTGAGAAGTGTCTCTTCATATCCTTCACCTACTTTTTGATGGGGTTTGTTTTTTTCTTGTAAGTTTGTTTGAGTTCCTTGTAGA
TTCTGGATATTAGCCCTTTGTCAGATGAGTAGATTGCAAAAATTTTCTCCCATTTTGTAGGTTGCCTGTTCACTCTGATGGTAGTTTCTT
TTGCTGTGCAGAAGCTCTTGAGTTTAATGAGATCCCATTTGTCAATTTTGGCTTCTGTTGCCATTGCTTTTGGTGTTTTAGACATGAAGT
CCTTGCCCATGCCTGTGTCCTGAATGGTACTGCATAGGTTTTCTTCTAGGGTTTTTATGGTTTTAGGTCTAACATTTAAGTCTTTAATCC
ATCTTGAATTAATTTTTGTATAAGGTGTAAGGAAGGGATCCAGTTTCAGCTTTCTACATGTGGCTAGCCAGTTTTCCCAGCACCATTTAT
TAAATAGGGAATCCTTTCCCCATTTCTTGTTTTTGTCAGGTTTCTCAAAGATCAGATAGTTGTAGATGTGTGGTATTATTTCTGAGGGCT
CTGTTCTGTTCCATTGGTCTATATCTCTGTTTTGGTACTAGTACCATGCTGTTTTGGTTACTGCAGCCTTGTAGTATAGTTTGAAATCAG
GTAGCGTGATGCCTCCAGCTTTGTTCTTTTGGCTTAGGATCGTTTTGGCAGTGCAGGCTCTTTTTTGGTTCCACATGAACTTTAAAGTAG
TTTTTTCCAATTCTATGAAGAAAGTCATGGGTAGCTTGATGGGGATGGCATTGAATCTATAAATTACCTTGGGCAGTATAGCCATTTTCA
CGATATTGATTCTTCCTATCCATGAGCATGGAATGTTCTTCCATTTGTTTGTGTCCTCTTTTATTTCCTTGAGCAGTGGTTTGTAGTTCT
CCTTGAAGAGGTCCTTCACATCCCTTGTAAGTTGGATTCCTAGGTATTTTATTCTCTTTGAGGCAGTTGTGAATGGGAGTTCACTCATGA
TTTGGCTCTCTGTTTGTCTGTTGTTGGTGTATAAGAATGCTTGTGATTTTTGCACATTGATTTTGTATCCTGAGATTTTGCTGAAGTTGC
TTATCAAATTAAGGAGATTTTGGGCTGAGATGATGGGGTTTTCTAAATATAAAATCATGTCATCTGCAAACAGGGACAATTTGACTTCCT
CTTTTCCTTATTGAATACCCTTTATTTCTTTCTCCTGCCTGATGGCCCTGGCCAGAACTTCCAACACTATGTTGAATAGGAGTGGTGAGA
GAGGGCATCCCTGTCTTGTGCCAGTTTTCAAAGGGAATGCTTCCAGTTTTTGCCCATTCAGTCTGATATTGGCTGTGGGTTTGTCATAGA
TAGCTCTTATTATTTTGAGATATGTCCCATCAATACCTAATTCATTGAGAGTTTTTAGCATGAAGGGCTGTTGAATTTTGTCCAAGGCCT
TTTCTGCATCTGTTGAGATAATCATGTGGTTTTTGTCTTTGGTTCTGTTTATATGCTGGATTACTTTTATTGATTTGTGTATGTTGAACC
AGCCTTGCATCCCAGGGATGAAGCCCACTTGATCATGGTGGATAAGCTTTTTGATATGCTGCTGGATTCAGTTTGCCAGTATTTTATTGA
GGATTTTTGCATTGATTTTCATCAGGGATATTGGTCTAAAGTTCTCTTTTTTTGTTATGTCTCTGCCAGGCTTTGGTATCAGGATGATGC
TGGCTTCATAAAATGAGTTAGGGAGGATTCCCTCTTTTTCTATTGATTGGAATAGTTTCAGAAGGAATGGTACCAGCTCTTCCTTGTACC
TCTGGTAGAATTCGGCTGTGAATCCATCTTGTCCTGGACTTTTTTTGGTTGGTAGGCTATTAATTATTGCCTCAATTTCAGAGCCTGTTA
TTGGTCTATTCAGGGATTAAACTTCTTCCTGGTTTAGTTTTGAGAGGGTGTATGTGTCCAGGAATTTATCTATTTCTTCTAGATTTTCTA
GTTTATTTGCATAGAGGTGTTTATAGTATTCTCTGTGTACTCTGTATTTCTGTGGGATTGGTGGTGATATCCACTTTATCATTTTTTATT
GCATTTATTTGATTCTTCTCTCTTTTCTTGTTTATTAGTCTTGCTAGCGGTCTATCAATTGTGTTTATCTTTTCAAAAAACCAGCTCCTG
GATTCATTCATTTTTTGAAGGTTTTTTTGTGTCTCTGTCTCCTTCAGTTCTGCTCTGATCTTAGTTATTTCTTGTCTTCTGCTAGCTGTT
GAATGTGTTTGCTCTTGCTTCTCTAATATTTTTAATTGTGATGTTAGAGTGTCAATTTTAGATCTTTCCTGCTTTCTCTTGTGGGCACTT
AGTGCTGTAAATTTCCCTCTACACACTGCTTTAAATGTGTCCCAGAGATTCTGGTATGTTGTGTCTTTGTTCTCGTTGGTTTCAAAGAAC
ATCTTTATTTCTGCCTTCATTTTGTTATGTACCCAGTAGTCATTCAGGAGCAGGTTGTTCAGTTTCCATGTAGCTGAGTGGTTTTGAGTG
AGTTTCTTAATCCTGAGTTCTAGTTTGATTGCACTGTGGTCTGAGACAGTATGTTATAATTTCTGTTCTTTTACATTTGCTGAGGAGTGC
TTTACTTCCAACTATGTGGTCAATTTTGGAATAGGTGCGATGTGGTGCTGAGAAGAATGTATATTCTGTTGATTTGGGGTGGAGAGTTCT
GTAGATGTCTATTAGGTCTGCTTGGTGCAGAGCTGAATTCAATTCCTGGATATCCTTGTTAACTTTCTGTCTCGTTGATCTGTCTAATAT
TGACAGTGGGGTGTTAGAGTCTCCCATTGTTATTGTGTGGGAGTCTAAATCTCTTTGTAGGTCTCTAAGGACTTGGTTTATGAATCTGGG
TGCTCCTGTATTGGGTGCATATATATTTAAGATAGTTAGCTCTTCTTGTTGAATTGATCCCTTTACTATCATGTAATGGCCTTCTTTGTC
TCTTTTGATCTTTGTTGGTTTAAAGTCTGTTTTATCAGAGACTAGGATTGCAACCCCGGCCTTTTTTTTTGTTTTCCGTTTGCTTGGTAG
ATCTTCCTCCATCCTTTTATTTTGAGCCTATGTGTGTGTGTCTCTGTACGTGAGATGGGTTTCCTGAATACAGCACCCTGATGGGTCTTG
ACTCTTTATCCAGTGTGCCAGTCTGTGTCTTTTAATTGGAGCATTTAGCCCATTTACATTTAAGGTTAATATTGTTATGTGTGAATTTGA
TCCTGTCACTAGGATGTTCACTGGTTATTTTGCTCGTTAGTTGATGCAGTTTCTTCCTAGCCTCAATGGTCTTTACAATTTGGCATGTTT
TTGCAGTGGCTGATACTGGTTGTTCCATTCCATGTTTAGTGCTTCCTTCAGGAGCTCTTGTAAGGCAGGCCTGGTGGTGACAAAATCTCT
CAGCATTTGCTTGTTTGTAAAGGATTTTATTTCTCCTTCACTTATGAAGCTTAGTTTGGCTGGATATGAAATTCTGGGTTGAAAATTCTT
TTCTTCAAGAACGTTGAATATTGACCCCCACTCTCTTCTGGCTTGTAGAGTTTCTGCTGAGAGATCAGCTGTTAGTCTGATGGGCTTCCC
TTTGTGGGTAACCCGACCTTTCTCTCTGGCTGCCCTTAACATTTTTTCCTTCATTTCAACTTTGGTGAATCTGACAATTATGTGTCTTGG
AGTTGCTCTTCTCGAGGAGTATCTTTGTGGCGTTCTCTGTATTTCCTGAATTTGAATGTTGTCCTCCCTTGCTAGATTGGGGAAGTTCTC
CTGGATAATATCCTGCAGAGTGTTTTCCAGCTTGGTTCCATTCTCCCCGTCACTTTCAGGTACACCAATCAGACGTAGATTTGGTCTTTT
CACATAGTCCCATATTTCTTGGAAGCTTTGTTCGTTTCTTTTTACTCTTTTTTCTCTTAACTTCTCTTCTCACTTCATTTCATTCATCTG
ATCTTCAATCACTGATAACCTTTCTTCCAGTTGATCGAATTGGCTACTGAAGCTTGTGCATTCGTCACGTAGTTCTCATGCCATGGTTTT
CAGCTCCATCAGGTCATTTAAGGACTTCTCTATGCTGGTTATTCTAGTTAGCCATTTGTCTAATCTTTTTTCAAGGTTTTTAGGTTCTTT
GTGATGGGTTCGAACTTCCTCTTTTAGCTTGGAGAAGTTTGATCATCTGAAGCCTTCTTCTCTCAACTCGTCAAAGTCATTCTCCGTCCA
GCTTTGTTCTGTTGCTGGCAAGGAGCTATGTTCCTTTGGAGGGGGAGAGGCGCTCTGATTTTTAGAATTTTCAGCTTTTCTGCTCTGTTT
TTTCCCCATCTTTGTGGTTTTATCTACCTTTGGTCTTTGGTGATGGTGATGTGCAGATGGGGTTTTGGTGTGGATGTCCTTTCTGTTTGT
TAGTTTTCCTTCTAACAGTCAGGACCGCCAGCTGCAGGTCTGTTGGAGTTTGCTGGACGTCCACGCCAGACCCTGTTTGCCTGGGTATCA
CAGTGGAGGCTGTAGAACAGCGAATATTGCTGAACAGCAAATGTTGCTGCCTGATCATTCCTCTGGAAGCTTCATCTCAGAGGGGTACCC
GGCCATGTGGGGTGTCAGTCTGCCCCTACTTGGGGGTGCCTCCCAGTTAGGCTACTCGGGGGTCAGGGACTCACTTGAGGAGGCAGTCTC
TCCGTTCTCAGATCTCAAACTCTGTGCTGGGAGAACCACTGGTCTCTTCAAAGCTGTCAGACAGGGACATTGAAGTCTGCAGAGATTTCT
GCTGCCTTTTGTTCGGCTATGCCATGCCCCCAGAGGTGGAGTCTACAGAGGCAGGCAGGCAGGCCTCCTTGAGCTGCAGTGGGCTCCACC
TAGTTCGAGCTTCCCGGCTGCTTTATTTACCTACTGAAGCCTCAGCAATGGTGGGCTCCCCTCCCCTAGCCTCACTGCCACCTTGCAGTT
CGATCTCAGACTGCTGTGCTAGCAATGAGCAAGGCTCCATGGGCGTGGGACCCTCCGAGCTAGGCACAGGATATAATCTCCTGGTGTGCC
GTTTGCTAAGACCATTGGAAAAACGCAGTATTAGGGTGGGAGTGACCCAATTTTCCAGGTGCCGTCTGTCACAGCTTCCCTTGGCTAGGA
AAGGGAATTCCCTGACCCCTTGCCTTCCCGGGTGAGGCCATGCCTTGCCCTGCTTCAGCTCATGCTCAGTGGGCTGCACCCACCGTCCTA
CACCCACTGTCCAACAAGCCCCAGTGAGATGAACCTGGTACCTCAGTTGGAAGTGCAGAAATCACCTGTCTTCTGCGTCGCTCACGCTGG
GAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTGGAACCCAACCCAAGTCTGGCATTTTTTGGTTTTCTCTGTGTATTGACTATGA
TTATAGAGGATAAATGGATATTGATATTATTAAATCGTCATTTACAGAAGGCACACAACTTATATCCTTTAAACAAAGTTCTCCAACCAG
TAGGGTATACTTGCTGGTAGTGCTTACAGCTGCCACCATTCTTCACTGGGGCTCAGAGTGGATGCCTGGAGGAAAAAAACAAATGAATCT
TTTAGCTCCTAGTTACTGTTAGCATTTTTACCAGAAAACAATTTAAAAAATGACACAAGTAAGTCTTCACCTATCAAGGCTGAGTGTGGT
GGCCTATACTTGTAATCTCTGTGCTTTGGGAGGCCAACGCAGGAGGATCTCTTGAGTCCAGGAGTTTGAGACCAGCCTGGGCAACAAAGC
AAGACCCCATCTCTACAGAAAGTTAAAATTTAGCTGGGCATGCTGGCACATCCCTATAGTCCCAGCTACTTGAGAGGCTGAGTTGGGAGG
ATCCCTTGAGGTCATGAGTTGGAGTCTACAGTGAGCTGTGATTACAGTGTGAGTCTACACTGCACTCCAGTCTGGGTGAAAGAGATCCTG
TCTCTCAAAAAACAAGTGATTCTCCTGGGAAGAGATTTGTTTAAAAAGTCTGCACCTCTATTGATGATAACTTTGAATGTAAATGGATTA
AATTCTCCCACTTAAAAGATATAGATTGACTGAATGGATTAAAAACCACCATCATGACTCGACTGTATGCTGCCTACAAGAAACCTCACC
TGTAAAGACAGGCCAAAAGTGAAGGTATGGAGAAAGATATTGCATACAAATGGAAGCCAAAAAAGAGCAGAAATAACTATACTTACATGA
GATAAAATAGACTTTAAGTCAAAAACTGTAAAAAGAAAAGTCATTATGTAATGAAACAAGGATCAATTCATGCAAGATATAATCATATTT
TTTTATTAAGAAAATTTTTTTGTAGAGATGGGGTTATGCTATGTTGCCTGGCTAGTCTCAAACTCTGGGTCTCAAAGCAGTCCTCCTGCT
TTGGCCTCCTAAGGTGCTGGGATTATAGGCATGAGCCACTGTGCCAGGCCTGAGGATATTATCATTATAAATATATATGTACCCCACACT
GGATGACCCAGATATAAAGCAAATATTATTAGATTTAAAGGGAGAAATAGACTCTAATACAATAGTAGTTGAGGACTTCACTCTACTCTC
AGCATTGGACAGATTTTCTAGACATAAAACCAATAAATATTGGATTTAAATTGCACTTTACACCAAATGGACCTGACATTTACAGAACAT
TCTAATAGGTGCAGAACACTCTAATAGCTGCAGAACACACGTTCTTTTCATCAGCACATGGAACATTCACCAGACTAGTTCTGGAACCCA
CTTCCTGCCTTAGTGTTCTTTCCACCACAGTGCATGATAATTCCGACAGAACGCCTTTTATTTGTACCTTATTAGTTGTAGGGGGAAAGC

>56892_56892_7_MZT2B-SOD2_MZT2B_chr2_130940348_ENST00000409255_SOD2_chr6_160106065_ENST00000538183_length(amino acids)=214AA_BP=101
MAAQGVGPGPGSAAPPGLEAARQKLALRRKKVLSTEEMELYELAQAAGGAIDPDVFKILVDLLKLNVAPLAVFQMLKSMCAGQRLASEPQ
DPAAVSLPTSSVPETRGELLEAIKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHA

--------------------------------------------------------------
>56892_56892_8_MZT2B-SOD2_MZT2B_chr2_130940348_ENST00000409255_SOD2_chr6_160106065_ENST00000546087_length(transcript)=870nt_BP=345nt
AGCGCACCTTTCCGCGGGCCGCGGGGATGGCGGCGCAGGGCGTAGGGCCTGGGCCGGGGTCGGCGGCGCCCCCGGGGCTGGAGGCGGCCC
GGCAGAAGCTGGCGCTGCGGCGGAAGAAGGTGCTGAGCACCGAGGAGATGGAGCTGTACGAGCTGGCGCAGGCGGCGGGCGGCGCTATCG
ACCCCGACGTGTTCAAGATCCTGGTGGACCTGCTGAAGCTGAACGTGGCCCCCCTCGCCGTCTTCCAGATGCTCAAGTCCATGTGTGCCG
GGCAGAGGCTAGCGAGCGAGCCCCAGGACCCTGCGGCCGTGTCTCTGCCCACGTCGAGCGTGCCCGAGACCCGAGGGGAGTTGCTGGAAG
CCATCAAACGTGACTTTGGTTCCTTTGACAAGTTTAAGGAGAAGCTGACGGCTGCATCTGTTGGTGTCCAAGGCTCAGGTTGGGGTTGGC
TTGGTTTCAATAAGGAACGGGGACACTTACAAATTGCTGCTTGTCCAAATCAGGATCCACTGCAAGGAACAACAGGCCTTATTCCACTGC
TGGGGATTGATGTGTGGGAGCACGCTTACTACCTTCAGTATAAAAATGTCAGGCCTGATTATCTAAAAGCTATTTGGAATGTAATCAACT
GGGAGAATGTAACTGAAAGATACATGGCTTGCAAAAAGTAAACCACGATCGTTATGCTGATCATACCCTAATGATCCCAGCAAGATAATG
TCCTGTCTTCTAAGATGTGCATCAAGCCTGGTACATACTGAAAACCCTATAAGGTCCTGGATAATTTTTGTTTGATTATTCATTGAAGAA

>56892_56892_8_MZT2B-SOD2_MZT2B_chr2_130940348_ENST00000409255_SOD2_chr6_160106065_ENST00000546087_length(amino acids)=214AA_BP=101
MAAQGVGPGPGSAAPPGLEAARQKLALRRKKVLSTEEMELYELAQAAGGAIDPDVFKILVDLLKLNVAPLAVFQMLKSMCAGQRLASEPQ
DPAAVSLPTSSVPETRGELLEAIKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MZT2B-SOD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MZT2B-SOD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MZT2B-SOD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0033578Prostatic Neoplasms8CTD_human
TgeneC0376358Malignant neoplasm of prostate8CTD_human
TgeneC0235874Disease Exacerbation7CTD_human
TgeneC0006826Malignant Neoplasms6CTD_human
TgeneC0027626Neoplasm Invasiveness6CTD_human
TgeneC0027651Neoplasms6CTD_human
TgeneC0035126Reperfusion Injury6CTD_human
TgeneC0086692Benign Neoplasm6CTD_human
TgeneC0007621Neoplastic Cell Transformation5CTD_human
TgeneC0018801Heart failure5CTD_human
TgeneC0018802Congestive heart failure5CTD_human
TgeneC0023212Left-Sided Heart Failure5CTD_human
TgeneC0235527Heart Failure, Right-Sided5CTD_human
TgeneC1959583Myocardial Failure5CTD_human
TgeneC1961112Heart Decompensation5CTD_human
TgeneC0006142Malignant neoplasm of breast4CTD_human
TgeneC0007114Malignant neoplasm of skin4CTD_human
TgeneC0024623Malignant neoplasm of stomach4CTD_human
TgeneC0025500Mesothelioma4CTD_human
TgeneC0027627Neoplasm Metastasis4CTD_human
TgeneC0036341Schizophrenia4PSYGENET
TgeneC0037286Skin Neoplasms4CTD_human
TgeneC0038356Stomach Neoplasms4CTD_human
TgeneC0678222Breast Carcinoma4CTD_human
TgeneC1257931Mammary Neoplasms, Human4CTD_human
TgeneC1458155Mammary Neoplasms4CTD_human
TgeneC1708349Hereditary Diffuse Gastric Cancer4CTD_human
TgeneC2239176Liver carcinoma4CTD_human
TgeneC4704874Mammary Carcinoma, Human4CTD_human
TgeneC0003873Rheumatoid Arthritis3CTD_human
TgeneC0007786Brain Ischemia3CTD_human
TgeneC0020538Hypertensive disease3CTD_human
TgeneC0024232Lymphatic Metastasis3CTD_human
TgeneC0028754Obesity3CTD_human
TgeneC0029408Degenerative polyarthritis3CTD_human
TgeneC0030567Parkinson Disease3CTD_human
TgeneC0086743Osteoarthrosis Deformans3CTD_human
TgeneC0270715Degenerative Diseases, Central Nervous System3CTD_human
TgeneC0524851Neurodegenerative Disorders3CTD_human
TgeneC0751733Degenerative Diseases, Spinal Cord3CTD_human
TgeneC0917798Cerebral Ischemia3CTD_human
TgeneC0002152Alloxan Diabetes2CTD_human
TgeneC0002896Sideroblastic anemia2CTD_human
TgeneC0003129Anoxemia2CTD_human
TgeneC0003130Anoxia2CTD_human
TgeneC0004153Atherosclerosis2CTD_human
TgeneC0005586Bipolar Disorder2PSYGENET
TgeneC0005684Malignant neoplasm of urinary bladder2CTD_human
TgeneC0005695Bladder Neoplasm2CTD_human
TgeneC0007097Carcinoma2CTD_human
TgeneC0007131Non-Small Cell Lung Carcinoma2CTD_human
TgeneC0007137Squamous cell carcinoma2CTD_human
TgeneC0007193Cardiomyopathy, Dilated2CTD_human
TgeneC0009402Colorectal Carcinoma2CTD_human
TgeneC0009404Colorectal Neoplasms2CTD_human
TgeneC0011853Diabetes Mellitus, Experimental2CTD_human
TgeneC0014859Esophageal Neoplasms2CTD_human
TgeneC0022116Ischemia2CTD_human
TgeneC0022658Kidney Diseases2CTD_human
TgeneC0026640Mouth Neoplasms2CTD_human
TgeneC0027540Necrosis2CTD_human
TgeneC0032927Precancerous Conditions2CTD_human
TgeneC0034535Radiation Syndrome2CTD_human
TgeneC0038433Streptozotocin Diabetes2CTD_human
TgeneC0042164Uveitis2CTD_human
TgeneC0085207Gestational Diabetes2CTD_human
TgeneC0153381Malignant neoplasm of mouth2CTD_human
TgeneC0162674Chronic progressive external ophthalmoplegia2CTD_human
TgeneC0205696Anaplastic carcinoma2CTD_human
TgeneC0205697Carcinoma, Spindle-Cell2CTD_human
TgeneC0205698Undifferentiated carcinoma2CTD_human
TgeneC0205699Carcinomatosis2CTD_human
TgeneC0242184Hypoxia2CTD_human
TgeneC0279626Squamous cell carcinoma of esophagus2CTD_human
TgeneC0282313Condition, Preneoplastic2CTD_human
TgeneC0546837Malignant neoplasm of esophagus2CTD_human
TgeneC0700292Hypoxemia2CTD_human
TgeneC0919267ovarian neoplasm2CTD_human
TgeneC1140680Malignant neoplasm of ovary2CTD_human
TgeneC1449563Cardiomyopathy, Familial Idiopathic2CTD_human
TgeneC1510432Radiation Sickness2CTD_human
TgeneC1563937Atherogenesis2CTD_human
TgeneC0001418Adenocarcinoma1CTD_human
TgeneC0001787Osteoporosis, Age-Related1CTD_human
TgeneC0001925Albuminuria1CTD_human
TgeneC0001969Alcoholic Intoxication1PSYGENET
TgeneC0002390Extrinsic allergic alveolitis1CTD_human
TgeneC0002395Alzheimer's Disease1CTD_human
TgeneC0002736Amyotrophic Lateral Sclerosis1CTD_human
TgeneC0002871Anemia1CTD_human
TgeneC0003493Aortic Diseases1CTD_human
TgeneC0004045Asphyxia Neonatorum1CTD_human
TgeneC0004364Autoimmune Diseases1CTD_human
TgeneC0006118Brain Neoplasms1CTD_human
TgeneC0007102Malignant tumor of colon1CTD_human
TgeneC0007134Renal Cell Carcinoma1CTD_human
TgeneC0007682CNS disorder1CTD_human
TgeneC0007787Transient Ischemic Attack1CTD_human
TgeneC0009375Colonic Neoplasms1CTD_human
TgeneC0011265Presenile dementia1CTD_human
TgeneC0011570Mental Depression1PSYGENET
TgeneC0011574Involutional Depression1CTD_human
TgeneC0011581Depressive disorder1PSYGENET
TgeneC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneC0011881Diabetic Nephropathy1CTD_human
TgeneC0014866Esophageal Stenosis1CTD_human
TgeneC0014868Esophagitis1CTD_human
TgeneC0015695Fatty Liver1CTD_human
TgeneC0015967Fever1CTD_human
TgeneC0016059Fibrosis1CTD_human
TgeneC0017667Nodular glomerulosclerosis1CTD_human
TgeneC0018200Granuloma, Respiratory Tract1CTD_human
TgeneC0018800Cardiomegaly1CTD_human
TgeneC0019193Hepatitis, Toxic1CTD_human
TgeneC0020542Pulmonary Hypertension1CTD_human
TgeneC0020550Hyperthyroidism1CTD_human
TgeneC0020615Hypoglycemia1CTD_human
TgeneC0021364Male infertility1CTD_human
TgeneC0021367Mammary Ductal Carcinoma1CTD_human
TgeneC0021655Insulin Resistance1CTD_human
TgeneC0022333Jacksonian Seizure1CTD_human
TgeneC0022665Kidney Neoplasm1CTD_human
TgeneC0022672Acute Kidney Tubular Necrosis1CTD_human
TgeneC0023891Liver Cirrhosis, Alcoholic1CTD_human
TgeneC0024115Lung diseases1CTD_human
TgeneC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneC0024796Marfan Syndrome1CTD_human
TgeneC0025312Meningomyelocele1CTD_human
TgeneC0026764Multiple Myeloma1CTD_human
TgeneC0027051Myocardial Infarction1CTD_human
TgeneC0027726Nephrotic Syndrome1CTD_human
TgeneC0027746Nerve Degeneration1CTD_human
TgeneC0029456Osteoporosis1CTD_human
TgeneC0029459Osteoporosis, Senile1CTD_human
TgeneC0030246Pustulosis of Palms and Soles1CTD_human
TgeneC0030297Pancreatic Neoplasm1CTD_human
TgeneC0030354Papilloma1CTD_human
TgeneC0032580Adenomatous Polyposis Coli1CTD_human
TgeneC0033141Cardiomyopathies, Primary1CTD_human
TgeneC0033860Psoriasis1CTD_human
TgeneC0033937Psychoses, Drug1CTD_human
TgeneC0033941Psychoses, Substance-Induced1CTD_human
TgeneC0035222Respiratory Distress Syndrome, Adult1CTD_human
TgeneC0036202Sarcoidosis1CTD_human
TgeneC0036529Myocardial Diseases, Secondary1CTD_human
TgeneC0036572Seizures1CTD_human
TgeneC0036980Shock, Cardiogenic1CTD_human
TgeneC0037268Skin Abnormalities1CTD_human
TgeneC0037274Dermatologic disorders1CTD_human
TgeneC0040411Tongue Neoplasms1CTD_human
TgeneC0041408Turner Syndrome1CTD_human
TgeneC0042373Vascular Diseases1CTD_human
TgeneC0079744Diffuse Large B-Cell Lymphoma1CTD_human
TgeneC0086664Myelocele1CTD_human
TgeneC0149958Complex partial seizures1CTD_human
TgeneC0151526Premature Birth1CTD_human
TgeneC0151744Myocardial Ischemia1CTD_human
TgeneC0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneC0153349Malignant neoplasm of tongue1CTD_human
TgeneC0153633Malignant neoplasm of brain1CTD_human
TgeneC0162309Adrenoleukodystrophy1CTD_human
TgeneC0162671MELAS Syndrome1CTD_human
TgeneC0162871Aortic Aneurysm, Abdominal1CTD_human
TgeneC0205641Adenocarcinoma, Basal Cell1CTD_human
TgeneC0205642Adenocarcinoma, Oxyphilic1CTD_human
TgeneC0205643Carcinoma, Cribriform1CTD_human
TgeneC0205644Carcinoma, Granular Cell1CTD_human
TgeneC0205645Adenocarcinoma, Tubular1CTD_human
TgeneC0205874Papilloma, Squamous Cell1CTD_human
TgeneC0205875Papillomatosis1CTD_human
TgeneC0206061Pneumonia, Interstitial1CTD_human
TgeneC0206062Lung Diseases, Interstitial1CTD_human
TgeneC0206160Reticulocytosis1CTD_human
TgeneC0234533Generalized seizures1CTD_human
TgeneC0234535Clonic Seizures1CTD_human
TgeneC0235974Pancreatic carcinoma1CTD_human
TgeneC0238281Middle Cerebral Artery Syndrome1CTD_human
TgeneC0238461Anaplastic thyroid carcinoma1CTD_human
TgeneC0242526Gonadal Dysgenesis, 45,X1CTD_human
TgeneC0242698Ventricular Dysfunction, Left1CTD_human
TgeneC0242992Multiple Chemical Sensitivity1CTD_human
TgeneC0268255Farber Lipogranulomatosis1CTD_human
TgeneC0268583Methylmalonic acidemia1CTD_human
TgeneC0270824Visual seizure1CTD_human
TgeneC0270844Tonic Seizures1CTD_human
TgeneC0270846Epileptic drop attack1CTD_human
TgeneC0271708Fasting Hypoglycemia1CTD_human
TgeneC0271710Reactive hypoglycemia1CTD_human
TgeneC0274861Arsenic Poisoning, Inorganic1CTD_human
TgeneC0274862Nervous System, Organic Arsenic Poisoning1CTD_human
TgeneC0276496Familial Alzheimer Disease (FAD)1CTD_human
TgeneC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneC0311375Arsenic Poisoning1CTD_human
TgeneC0345967Malignant mesothelioma1CTD_human
TgeneC0346647Malignant neoplasm of pancreas1CTD_human
TgeneC0376618Endotoxemia1CTD_human
TgeneC0393554Amyotrophic Lateral Sclerosis With Dementia1CTD_human
TgeneC0422850Seizures, Somatosensory1CTD_human
TgeneC0422852Seizures, Auditory1CTD_human
TgeneC0422853Olfactory seizure1CTD_human
TgeneC0422854Gustatory seizure1CTD_human
TgeneC0422855Vertiginous seizure1CTD_human
TgeneC0472381Posterior Circulation Transient Ischemic Attack1CTD_human
TgeneC0494463Alzheimer Disease, Late Onset1CTD_human
TgeneC0494475Tonic - clonic seizures1CTD_human
TgeneC0496899Benign neoplasm of brain, unspecified1CTD_human
TgeneC0520459Necrotizing Enterocolitis1CTD_human
TgeneC0543859Amyotrophic Lateral Sclerosis, Guam Form1CTD_human
TgeneC0546126Acute Confusional Senile Dementia1CTD_human
TgeneC0740376Middle Cerebral Artery Thrombosis1CTD_human
TgeneC0740391Middle Cerebral Artery Occlusion1CTD_human
TgeneC0740392Infarction, Middle Cerebral Artery1CTD_human
TgeneC0740457Malignant neoplasm of kidney1CTD_human
TgeneC0750900Alzheimer's Disease, Focal Onset1CTD_human
TgeneC0750901Alzheimer Disease, Early Onset1CTD_human
TgeneC0750974Brain Tumor, Primary1CTD_human
TgeneC0750977Recurrent Brain Neoplasm1CTD_human
TgeneC0750979Primary malignant neoplasm of brain1CTD_human
TgeneC0751019Carotid Circulation Transient Ischemic Attack1CTD_human
TgeneC0751020Transient Ischemic Attack, Vertebrobasilar Circulation1CTD_human
TgeneC0751021Crescendo Transient Ischemic Attacks1CTD_human
TgeneC0751022Brain Stem Ischemia, Transient1CTD_human
TgeneC0751056Non-epileptic convulsion1CTD_human
TgeneC0751110Single Seizure1CTD_human
TgeneC0751123Atonic Absence Seizures1CTD_human
TgeneC0751316Acquired Meningomyelocele1CTD_human
TgeneC0751406Post-Traumatic Osteoporosis1CTD_human
TgeneC0751494Convulsive Seizures1CTD_human
TgeneC0751495Seizures, Focal1CTD_human
TgeneC0751496Seizures, Sensory1CTD_human
TgeneC0751651Mitochondrial Diseases1CTD_human
TgeneC0751845Middle Cerebral Artery Embolus1CTD_human
TgeneC0751846Left Middle Cerebral Artery Infarction1CTD_human
TgeneC0751847Embolic Infarction, Middle Cerebral Artery1CTD_human
TgeneC0751848Thrombotic Infarction, Middle Cerebral Artery1CTD_human
TgeneC0751849Right Middle Cerebral Artery Infarction1CTD_human
TgeneC0751851Arsenic Encephalopathy1CTD_human
TgeneC0751852Arsenic Induced Polyneuropathy1CTD_human
TgeneC0752347Lewy Body Disease1CTD_human
TgeneC0848676Subfertility, Male1CTD_human
TgeneC0860207Drug-Induced Liver Disease1CTD_human
TgeneC0878544Cardiomyopathies1CTD_human
TgeneC0917731Male sterility1CTD_human
TgeneC0917805Transient Cerebral Ischemia1CTD_human
TgeneC0920563Insulin Sensitivity1CTD_human
TgeneC0948089Acute Coronary Syndrome1CTD_human
TgeneC0949855Electron Transport Chain Deficiencies, Mitochondrial1CTD_human
TgeneC0949856Oxidative Phosphorylation Deficiencies1CTD_human
TgeneC0949857Mitochondrial Respiratory Chain Deficiencies1CTD_human
TgeneC1134719Invasive Ductal Breast Carcinoma1CTD_human
TgeneC1168401Squamous cell carcinoma of the head and neck1CTD_human
TgeneC1262760Hepatitis, Drug-Induced1CTD_human
TgeneC1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneC1269683Major Depressive Disorder1CTD_human
TgeneC1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneC1383860Cardiac Hypertrophy1CTD_human
TgeneC1527168Bonnevie-Ullrich Syndrome1CTD_human
TgeneC1527231Adrenomyeloneuropathy1CTD_human
TgeneC1527335Transient Ischemic Attack, Anterior Circulation1CTD_human
TgeneC1527390Neoplasms, Intracranial1CTD_human
TgeneC1571983Involutional paraphrenia1CTD_human
TgeneC1571984Psychosis, Involutional1CTD_human
TgeneC1623038Cirrhosis1CTD_human
TgeneC1855119Methylmalonic aciduria1CTD_human
TgeneC1859317Cataract and cardiomyopathy1CTD_human
TgeneC2711227Steatohepatitis1CTD_human
TgeneC2713442Polyposis, Adenomatous Intestinal1CTD_human
TgeneC2713443Familial Intestinal Polyposis1CTD_human
TgeneC2931822Nasopharyngeal carcinoma1CTD_human
TgeneC3495874Nonepileptic Seizures1CTD_human
TgeneC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneC3714618Primary Hyperthyroidism1CTD_human
TgeneC4048158Convulsions1CTD_human
TgeneC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneC4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneC4316903Absence Seizures1CTD_human
TgeneC4317109Epileptic Seizures1CTD_human
TgeneC4317123Myoclonic Seizures1CTD_human
TgeneC4505436Generalized Absence Seizures1CTD_human
TgeneC4551650Esophageal Stricture1CTD_human
TgeneC4721453Peripheral Nervous System Diseases1CTD_human
TgeneC4721845Marfan Syndrome, Type I1CTD_human