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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MLLT10-HTR2C (FusionGDB2 ID:HG8028TG3358)

Fusion Gene Summary for MLLT10-HTR2C

check button Fusion gene summary
Fusion gene informationFusion gene name: MLLT10-HTR2C
Fusion gene ID: hg8028tg3358
HgeneTgene
Gene symbol

MLLT10

HTR2C

Gene ID

8028

3358

Gene nameMLLT10 histone lysine methyltransferase DOT1L cofactor5-hydroxytryptamine receptor 2C
SynonymsAF105-HT1C|5-HT2C|5-HTR2C|5HTR2C|HTR1C
Cytomap('MLLT10')('HTR2C')

10p12.31

Xq23

Type of geneprotein-codingprotein-coding
Descriptionprotein AF-10ALL1-fused gene from chromosome 10 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10type I AF10 proteintype III AF10 prot5-hydroxytryptamine receptor 2C5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled5-hydroxytryptamine receptor 1Cserotonin 5-HT-1C receptorserotonin 5-HT-2C receptor
Modification date2020031320200313
UniProtAcc

P55197

.
Ensembl transtripts involved in fusion geneENST00000307729, ENST00000377059, 
ENST00000377072, ENST00000377091, 
ENST00000377100, ENST00000446906, 
ENST00000495130, 
Fusion gene scores* DoF score18 X 15 X 10=27003 X 4 X 2=24
# samples 244
** MAII scorelog2(24/2700*10)=-3.49185309632968
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MLLT10 [Title/Abstract] AND HTR2C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMLLT10(21954177)-HTR2C(114108084), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMLLT10

GO:0045944

positive regulation of transcription by RNA polymerase II

17868029

TgeneHTR2C

GO:0006874

cellular calcium ion homeostasis

19057895

TgeneHTR2C

GO:0007200

phospholipase C-activating G protein-coupled receptor signaling pathway

12970106

TgeneHTR2C

GO:0010513

positive regulation of phosphatidylinositol biosynthetic process

19057895

TgeneHTR2C

GO:0019934

cGMP-mediated signaling

12970106

TgeneHTR2C

GO:0042493

response to drug

18703043

TgeneHTR2C

GO:0070374

positive regulation of ERK1 and ERK2 cascade

19057895



check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AEC572737MLLT10chr10

21954177

-HTR2CchrX

114108084

-


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Fusion Gene ORF analysis for MLLT10-HTR2C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000307729ENST00000276198MLLT10chr10

21954177

-HTR2CchrX

114108084

-
intron-intronENST00000307729ENST00000371950MLLT10chr10

21954177

-HTR2CchrX

114108084

-
intron-intronENST00000307729ENST00000371951MLLT10chr10

21954177

-HTR2CchrX

114108084

-
intron-intronENST00000377059ENST00000276198MLLT10chr10

21954177

-HTR2CchrX

114108084

-
intron-intronENST00000377059ENST00000371950MLLT10chr10

21954177

-HTR2CchrX

114108084

-
intron-intronENST00000377059ENST00000371951MLLT10chr10

21954177

-HTR2CchrX

114108084

-
intron-intronENST00000377072ENST00000276198MLLT10chr10

21954177

-HTR2CchrX

114108084

-
intron-intronENST00000377072ENST00000371950MLLT10chr10

21954177

-HTR2CchrX

114108084

-
intron-intronENST00000377072ENST00000371951MLLT10chr10

21954177

-HTR2CchrX

114108084

-
intron-intronENST00000377091ENST00000276198MLLT10chr10

21954177

-HTR2CchrX

114108084

-
intron-intronENST00000377091ENST00000371950MLLT10chr10

21954177

-HTR2CchrX

114108084

-
intron-intronENST00000377091ENST00000371951MLLT10chr10

21954177

-HTR2CchrX

114108084

-
intron-intronENST00000377100ENST00000276198MLLT10chr10

21954177

-HTR2CchrX

114108084

-
intron-intronENST00000377100ENST00000371950MLLT10chr10

21954177

-HTR2CchrX

114108084

-
intron-intronENST00000377100ENST00000371951MLLT10chr10

21954177

-HTR2CchrX

114108084

-
intron-intronENST00000446906ENST00000276198MLLT10chr10

21954177

-HTR2CchrX

114108084

-
intron-intronENST00000446906ENST00000371950MLLT10chr10

21954177

-HTR2CchrX

114108084

-
intron-intronENST00000446906ENST00000371951MLLT10chr10

21954177

-HTR2CchrX

114108084

-
intron-intronENST00000495130ENST00000276198MLLT10chr10

21954177

-HTR2CchrX

114108084

-
intron-intronENST00000495130ENST00000371950MLLT10chr10

21954177

-HTR2CchrX

114108084

-
intron-intronENST00000495130ENST00000371951MLLT10chr10

21954177

-HTR2CchrX

114108084

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MLLT10-HTR2C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for MLLT10-HTR2C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:21954177/:114108084)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MLLT10

P55197

.
FUNCTION: Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MLLT10-HTR2C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MLLT10-HTR2C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MLLT10-HTR2C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MLLT10-HTR2C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMLLT10C0007134Renal Cell Carcinoma1CTD_human
HgeneMLLT10C0025202melanoma1CTD_human
HgeneMLLT10C0025286Meningioma1CTD_human
HgeneMLLT10C0205834Meningiomas, Multiple1CTD_human
HgeneMLLT10C0259785Malignant Meningioma1CTD_human
HgeneMLLT10C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
HgeneMLLT10C0281784Benign Meningioma1CTD_human
HgeneMLLT10C0334605Meningothelial meningioma1CTD_human
HgeneMLLT10C0334606Fibrous Meningioma1CTD_human
HgeneMLLT10C0334607Psammomatous Meningioma1CTD_human
HgeneMLLT10C0334608Angiomatous Meningioma1CTD_human
HgeneMLLT10C0334609Hemangioblastic Meningioma1CTD_human
HgeneMLLT10C0334610Hemangiopericytic Meningioma1CTD_human
HgeneMLLT10C0334611Transitional Meningioma1CTD_human
HgeneMLLT10C0347515Spinal Meningioma1CTD_human
HgeneMLLT10C0349604Intracranial Meningioma1CTD_human
HgeneMLLT10C0431121Clear Cell Meningioma1CTD_human
HgeneMLLT10C0457190Xanthomatous Meningioma1CTD_human
HgeneMLLT10C0751303Cerebral Convexity Meningioma1CTD_human
HgeneMLLT10C0751304Parasagittal Meningioma1CTD_human
HgeneMLLT10C1266042Chromophobe Renal Cell Carcinoma1CTD_human
HgeneMLLT10C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
HgeneMLLT10C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
HgeneMLLT10C1306837Papillary Renal Cell Carcinoma1CTD_human
HgeneMLLT10C1334261Intraorbital Meningioma1CTD_human
HgeneMLLT10C1334271Intraventricular Meningioma1CTD_human
HgeneMLLT10C1335107Olfactory Groove Meningioma1CTD_human
HgeneMLLT10C1384406Secretory meningioma1CTD_human
HgeneMLLT10C1384408Microcystic meningioma1CTD_human
HgeneMLLT10C1527197Angioblastic Meningioma1CTD_human
HgeneMLLT10C1565950Posterior Fossa Meningioma1CTD_human
HgeneMLLT10C1565951Sphenoid Wing Meningioma1CTD_human
HgeneMLLT10C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1ORPHANET
HgeneMLLT10C3163622Papillary Meningioma1CTD_human
TgeneC0001973Alcoholic Intoxication, Chronic5PSYGENET
TgeneC0005586Bipolar Disorder5PSYGENET
TgeneC0011570Mental Depression5PSYGENET
TgeneC0011581Depressive disorder5PSYGENET
TgeneC0041696Unipolar Depression5PSYGENET
TgeneC0525045Mood Disorders5PSYGENET
TgeneC1269683Major Depressive Disorder5PSYGENET
TgeneC0036341Schizophrenia4PSYGENET
TgeneC0524620Metabolic Syndrome X3CTD_human
TgeneC0028754Obesity2CTD_human
TgeneC0043094Weight Gain2CTD_human
TgeneC0085159Seasonal Affective Disorder2PSYGENET
TgeneC0009171Cocaine Abuse1PSYGENET
TgeneC0027796Neuralgia1CTD_human
TgeneC0038587Substance Withdrawal Syndrome1CTD_human
TgeneC0038870Neuralgia, Supraorbital1CTD_human
TgeneC0042656Neuralgia, Vidian1CTD_human
TgeneC0086189Drug Withdrawal Symptoms1CTD_human
TgeneC0087169Withdrawal Symptoms1CTD_human
TgeneC0234247Neuralgia, Atypical1CTD_human
TgeneC0234249Neuralgia, Stump1CTD_human
TgeneC0423711Neuralgia, Perineal1CTD_human
TgeneC0423712Neuralgia, Iliohypogastric Nerve1CTD_human
TgeneC0751217Hyperkinesia, Generalized1CTD_human
TgeneC0751371Neuralgia, Ilioinguinal1CTD_human
TgeneC0751372Nerve Pain1CTD_human
TgeneC0751373Paroxysmal Nerve Pain1CTD_human
TgeneC3887506Hyperkinesia1CTD_human