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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NCOA3-ACTR5 (FusionGDB2 ID:HG8202TG79913)

Fusion Gene Summary for NCOA3-ACTR5

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOA3-ACTR5
Fusion gene ID: hg8202tg79913
HgeneTgene
Gene symbol

NCOA3

ACTR5

Gene ID

8202

79913

Gene namenuclear receptor coactivator 3actin related protein 5
SynonymsACTR|AIB-1|AIB1|CAGH16|CTG26|KAT13B|RAC3|SRC-3|SRC3|TNRC14|TNRC16|TRAM-1|bHLHe42|pCIPArp5|INO80M
Cytomap('NCOA3')('ACTR5')

20q13.12

20q11.23

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor coactivator 3CBP-interacting proteinamplified in breast cancer 1 proteinclass E basic helix-loop-helix protein 42receptor-associated coactivator 3steroid receptor coactivator protein 3thyroid hormone receptor activator molecule 1actin-related protein 5ARP5 actin related protein 5 homologINO80 complex subunit MhARP5sarcoma antigen NY-SAR-16
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000497292, ENST00000341724, 
ENST00000371997, ENST00000371998, 
ENST00000372004, 
Fusion gene scores* DoF score27 X 14 X 11=41584 X 3 X 3=36
# samples 354
** MAII scorelog2(35/4158*10)=-3.57046293102604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NCOA3 [Title/Abstract] AND ACTR5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNCOA3(46256767)-ACTR5(37383599), # samples:1
Anticipated loss of major functional domain due to fusion event.NCOA3-ACTR5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NCOA3-ACTR5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NCOA3-ACTR5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NCOA3-ACTR5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCOA3

GO:0045944

positive regulation of transcription by RNA polymerase II

9267036

HgeneNCOA3

GO:0071392

cellular response to estradiol stimulus

15831516


check buttonFusion gene breakpoints across NCOA3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ACTR5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-GI-A2C9NCOA3chr20

46256767

+ACTR5chr20

37383599

+


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Fusion Gene ORF analysis for NCOA3-ACTR5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000497292ENST00000243903NCOA3chr20

46256767

+ACTR5chr20

37383599

+
In-frameENST00000341724ENST00000243903NCOA3chr20

46256767

+ACTR5chr20

37383599

+
In-frameENST00000371997ENST00000243903NCOA3chr20

46256767

+ACTR5chr20

37383599

+
In-frameENST00000371998ENST00000243903NCOA3chr20

46256767

+ACTR5chr20

37383599

+
In-frameENST00000372004ENST00000243903NCOA3chr20

46256767

+ACTR5chr20

37383599

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000341724NCOA3chr2046256767+ENST00000243903ACTR5chr2037383599+250810842612132623
ENST00000372004NCOA3chr2046256767+ENST00000243903ACTR5chr2037383599+246310392162087623
ENST00000371998NCOA3chr2046256767+ENST00000243903ACTR5chr2037383599+243810141912062623
ENST00000371997NCOA3chr2046256767+ENST00000243903ACTR5chr2037383599+242410001772048623

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000341724ENST00000243903NCOA3chr2046256767+ACTR5chr2037383599+0.0019429470.99805707
ENST00000372004ENST00000243903NCOA3chr2046256767+ACTR5chr2037383599+0.0019892630.9980108
ENST00000371998ENST00000243903NCOA3chr2046256767+ACTR5chr2037383599+0.0018696860.9981304
ENST00000371997ENST00000243903NCOA3chr2046256767+ACTR5chr2037383599+0.0018966840.99810326

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Fusion Genomic Features for NCOA3-ACTR5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NCOA3chr2046256767+ACTR5chr2037383599+3.54E-060.9999964
NCOA3chr2046256767+ACTR5chr2037383599+3.54E-060.9999964

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NCOA3-ACTR5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:46256767/chr20:37383599)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOA3chr20:46256767chr20:37383599ENST00000371997+823110_1802741416.0DomainPAS
HgeneNCOA3chr20:46256767chr20:37383599ENST00000371997+82325_822741416.0DomainbHLH
HgeneNCOA3chr20:46256767chr20:37383599ENST00000371998+823110_1802741425.0DomainPAS
HgeneNCOA3chr20:46256767chr20:37383599ENST00000371998+82325_822741425.0DomainbHLH
HgeneNCOA3chr20:46256767chr20:37383599ENST00000372004+823110_1802741421.0DomainPAS
HgeneNCOA3chr20:46256767chr20:37383599ENST00000372004+82325_822741421.0DomainbHLH
TgeneACTR5chr20:46256767chr20:37383599ENST0000024390329288_327258608.0Coiled coilOntology_term=ECO:0000255
TgeneACTR5chr20:46256767chr20:37383599ENST0000024390329355_384258608.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOA3chr20:46256767chr20:37383599ENST00000371997+8231248_12782741416.0Compositional biasNote=Poly-Gln
HgeneNCOA3chr20:46256767chr20:37383599ENST00000371997+8231392_14172741416.0Compositional biasNote=Met-rich
HgeneNCOA3chr20:46256767chr20:37383599ENST00000371997+823505_6712741416.0Compositional biasNote=Ser-rich
HgeneNCOA3chr20:46256767chr20:37383599ENST00000371997+823976_9802741416.0Compositional biasNote=Poly-Gln
HgeneNCOA3chr20:46256767chr20:37383599ENST00000371998+8231248_12782741425.0Compositional biasNote=Poly-Gln
HgeneNCOA3chr20:46256767chr20:37383599ENST00000371998+8231392_14172741425.0Compositional biasNote=Met-rich
HgeneNCOA3chr20:46256767chr20:37383599ENST00000371998+823505_6712741425.0Compositional biasNote=Ser-rich
HgeneNCOA3chr20:46256767chr20:37383599ENST00000371998+823976_9802741425.0Compositional biasNote=Poly-Gln
HgeneNCOA3chr20:46256767chr20:37383599ENST00000372004+8231248_12782741421.0Compositional biasNote=Poly-Gln
HgeneNCOA3chr20:46256767chr20:37383599ENST00000372004+8231392_14172741421.0Compositional biasNote=Met-rich
HgeneNCOA3chr20:46256767chr20:37383599ENST00000372004+823505_6712741421.0Compositional biasNote=Ser-rich
HgeneNCOA3chr20:46256767chr20:37383599ENST00000372004+823976_9802741421.0Compositional biasNote=Poly-Gln
HgeneNCOA3chr20:46256767chr20:37383599ENST00000371997+8231057_10612741416.0MotifNote=LXXLL motif 3
HgeneNCOA3chr20:46256767chr20:37383599ENST00000371997+823685_6892741416.0MotifNote=LXXLL motif 1
HgeneNCOA3chr20:46256767chr20:37383599ENST00000371997+823738_7422741416.0MotifNote=LXXLL motif 2
HgeneNCOA3chr20:46256767chr20:37383599ENST00000371998+8231057_10612741425.0MotifNote=LXXLL motif 3
HgeneNCOA3chr20:46256767chr20:37383599ENST00000371998+823685_6892741425.0MotifNote=LXXLL motif 1
HgeneNCOA3chr20:46256767chr20:37383599ENST00000371998+823738_7422741425.0MotifNote=LXXLL motif 2
HgeneNCOA3chr20:46256767chr20:37383599ENST00000372004+8231057_10612741421.0MotifNote=LXXLL motif 3
HgeneNCOA3chr20:46256767chr20:37383599ENST00000372004+823685_6892741421.0MotifNote=LXXLL motif 1
HgeneNCOA3chr20:46256767chr20:37383599ENST00000372004+823738_7422741421.0MotifNote=LXXLL motif 2
HgeneNCOA3chr20:46256767chr20:37383599ENST00000371997+8231097_13042741416.0RegionNote=Acetyltransferase
HgeneNCOA3chr20:46256767chr20:37383599ENST00000371998+8231097_13042741425.0RegionNote=Acetyltransferase
HgeneNCOA3chr20:46256767chr20:37383599ENST00000372004+8231097_13042741421.0RegionNote=Acetyltransferase


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Fusion Gene Sequence for NCOA3-ACTR5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57729_57729_1_NCOA3-ACTR5_NCOA3_chr20_46256767_ENST00000341724_ACTR5_chr20_37383599_ENST00000243903_length(transcript)=2508nt_BP=1084nt
ATATCCCAGTGGCCCCCGTGCGGCGACTTTAGCTGCTGCTGTCTCAGCCGCTCCACAGCGACGGCAGCGGCTGCGGCTTAGTCGGTGGCG
GCCGGCGGCGGCTGCGGGCTGAGCGGCGAGTTTCCGATTTAAAGCTGAGCTGCGAGGAAAATGGCGGCGGGAGGATCAAAATACTTGCTG
GATGGTGGACTCAGAGACCAATAAAAATAAACTGCTTGAACATCCTTTGACTGGTTAGCCAGTTGCTGATGTATATTCAAGATGAGTGGA
TTAGGAGAAAACTTGGATCCACTGGCCAGTGATTCACGAAAACGCAAATTGCCATGTGATACTCCAGGACAAGGTCTTACCTGCAGTGGT
GAAAAACGGAGACGGGAGCAGGAAAGTAAATATATTGAAGAATTGGCTGAGCTGATATCTGCCAATCTTAGTGATATTGACAATTTCAAT
GTCAAACCAGATAAATGTGCGATTTTAAAGGAAACAGTAAGACAGATACGTCAAATAAAAGAGCAAGGAAAAACTATTTCCAATGATGAT
GATGTTCAAAAAGCCGATGTATCTTCTACAGGGCAGGGAGTTATTGATAAAGACTCCTTAGGACCGCTTTTACTTCAGGCATTGGATGGT
TTCCTATTTGTGGTGAATCGAGACGGAAACATTGTATTTGTATCAGAAAATGTCACACAATACCTGCAATATAAGCAAGAGGACCTGGTT
AACACAAGTGTTTACAATATCTTACATGAAGAAGACAGAAAGGATTTTCTTAAGAATTTACCAAAATCTACAGTTAATGGAGTTTCCTGG
ACAAATGAGACCCAAAGACAAAAAAGCCATACATTTAATTGCCGTATGTTGATGAAAACACCACATGATATTCTGGAAGACATAAACGCC
AGTCCTGAAATGCGCCAGAGATATGAAACAATGCAGTGCTTTGCCCTGTCTCAGCCACGAGCTATGATGGAGGAAGGGGAAGATTTGCAA
TCTTGTATGATCTGTGTGGCACGCCGCATTACTACAGGAGAAAGAACATTTCCATCAAACCCTGAGAGCTTTATTACCAGACATGATCTT
TCAGAATTACACAAATGGCGGTGTCCTGATTATTATGAGAATAATGTCCACAAGATGCAGCTCCCATTTTCCAGCAAGCTCCTGGGCAGC
ACTCTGACCTCTGAGGAGAAACAAGAAAGGCGGCAGCAGCAATTGCGGCGGCTGCAGGAGCTCAATGCCCGGCGGCGGGAGGAGAAGCTG
CAGCTGGATCAGGAGCGTCTGGACCGACTGCTATATGTGCAGGAACTTCTAGAGGATGGCCAGATGGATCAGTTTCACAAAGCTCTGATA
GAGCTGAATATGGACTCCCCAGAAGAGCTGCAGTCCTACATCCAGAAGCTCAGTATAGCAGTGGAGCAGGCTAAGCAGAAAATCCTCCAA
GCGGAAGTCAACCTCGAGGTGGATGTGGTAGACAGCAAGCCAGAGACCCCTGACCTGGAGCAGCTGGAGCCGTCTTTGGAAGATGTGGAA
AGCATGAATGATTTTGATCCCTTGTTTTCAGAGGAAACACCTGGAGTGGAGAAGCCGGTCACCACTGTTCAGCCCGTGTTTAACTTGGCA
GCATATCATCAGCTATTTGTTGGGACAGAAAGAATTCGAGCTCCAGAGATTATTTTCCAGCCATCTCTCATAGGAGAAGAACAGGCTGGG
ATTGCAGAGACTCTTCAGTACATTCTGGACAGGTACCCAAAGGACATTCAGGAAATGCTGGTTCAGAACGTTTTCCTCACTGGCGGCAAC
ACGATGTATCCTGGCATGAAAGCCAGAATGGAGAAGGAACTGTTGGAGATGAGACCCTTCCGGTCTTCTTTTCAGGTTCAACTTGCCTCG
AACCCTGTGCTGGATGCCTGGTACGGTGCTCGTGACTGGGCCTTGAACCACCTAGATGATAATGAAGTTTGGATCACCAGGAAAGAGTAT
GAAGAAAAGGGAGGAGAGTACCTCAAGGAGCACTGTGCTTCCAACATCTATGTCCCCATCCGCCTGCCGAAGCAGGCCTCCCGCTCCTCA
GATGCCCAGGCATCCAGCAAGGGCTCCGCTGCTGGTGGAGGTGGTGCTGGTGAGCAGGCATAGCAGAGGCCCTCCAGAGAGACTGCCCTG
CACGCCATGCCTTGGGCCACGTTGGCAGTGTGACAGGACTGTGATTGTGCTAGATGTACCTGCCCAAGTCTGCTGGTCACATTTGGCAGC
AAAATGGATTTCTCCTGGGGAGAACAAAGTTAAGGGACACTGAGACCTGCCCTTCAGAATTCGGTTCACTTGGGGGCTTCTGTGGTAGAG
ACTAACTGGCCTTCTGATGTCTTTGTTCAACTGTGGCCAGCTGTGGCATCAGCTTCCTGGAGCAGTAAATGAAGACAGAGTGGAGGACAC

>57729_57729_1_NCOA3-ACTR5_NCOA3_chr20_46256767_ENST00000341724_ACTR5_chr20_37383599_ENST00000243903_length(amino acids)=623AA_BP=274
MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTIS
NDDDVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNLPKSTVNG
VSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMMEEGEDLQSCMICVARRITTGERTFPSNPESFITR
HDLSELHKWRCPDYYENNVHKMQLPFSSKLLGSTLTSEEKQERRQQQLRRLQELNARRREEKLQLDQERLDRLLYVQELLEDGQMDQFHK
ALIELNMDSPEELQSYIQKLSIAVEQAKQKILQAEVNLEVDVVDSKPETPDLEQLEPSLEDVESMNDFDPLFSEETPGVEKPVTTVQPVF
NLAAYHQLFVGTERIRAPEIIFQPSLIGEEQAGIAETLQYILDRYPKDIQEMLVQNVFLTGGNTMYPGMKARMEKELLEMRPFRSSFQVQ

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>57729_57729_2_NCOA3-ACTR5_NCOA3_chr20_46256767_ENST00000371997_ACTR5_chr20_37383599_ENST00000243903_length(transcript)=2424nt_BP=1000nt
GTGGCGGCCGGCGGCGGCTGCGGGCTGAGCGGCGAGTTTCCGATTTAAAGCTGAGCTGCGAGGAAAATGGCGGCGGGAGGATCAAAATAC
TTGCTGGATGGTGGACTCAGAGACCAATAAAAATAAACTGCTTGAACATCCTTTGACTGGTTAGCCAGTTGCTGATGTATATTCAAGATG
AGTGGATTAGGAGAAAACTTGGATCCACTGGCCAGTGATTCACGAAAACGCAAATTGCCATGTGATACTCCAGGACAAGGTCTTACCTGC
AGTGGTGAAAAACGGAGACGGGAGCAGGAAAGTAAATATATTGAAGAATTGGCTGAGCTGATATCTGCCAATCTTAGTGATATTGACAAT
TTCAATGTCAAACCAGATAAATGTGCGATTTTAAAGGAAACAGTAAGACAGATACGTCAAATAAAAGAGCAAGGAAAAACTATTTCCAAT
GATGATGATGTTCAAAAAGCCGATGTATCTTCTACAGGGCAGGGAGTTATTGATAAAGACTCCTTAGGACCGCTTTTACTTCAGGCATTG
GATGGTTTCCTATTTGTGGTGAATCGAGACGGAAACATTGTATTTGTATCAGAAAATGTCACACAATACCTGCAATATAAGCAAGAGGAC
CTGGTTAACACAAGTGTTTACAATATCTTACATGAAGAAGACAGAAAGGATTTTCTTAAGAATTTACCAAAATCTACAGTTAATGGAGTT
TCCTGGACAAATGAGACCCAAAGACAAAAAAGCCATACATTTAATTGCCGTATGTTGATGAAAACACCACATGATATTCTGGAAGACATA
AACGCCAGTCCTGAAATGCGCCAGAGATATGAAACAATGCAGTGCTTTGCCCTGTCTCAGCCACGAGCTATGATGGAGGAAGGGGAAGAT
TTGCAATCTTGTATGATCTGTGTGGCACGCCGCATTACTACAGGAGAAAGAACATTTCCATCAAACCCTGAGAGCTTTATTACCAGACAT
GATCTTTCAGAATTACACAAATGGCGGTGTCCTGATTATTATGAGAATAATGTCCACAAGATGCAGCTCCCATTTTCCAGCAAGCTCCTG
GGCAGCACTCTGACCTCTGAGGAGAAACAAGAAAGGCGGCAGCAGCAATTGCGGCGGCTGCAGGAGCTCAATGCCCGGCGGCGGGAGGAG
AAGCTGCAGCTGGATCAGGAGCGTCTGGACCGACTGCTATATGTGCAGGAACTTCTAGAGGATGGCCAGATGGATCAGTTTCACAAAGCT
CTGATAGAGCTGAATATGGACTCCCCAGAAGAGCTGCAGTCCTACATCCAGAAGCTCAGTATAGCAGTGGAGCAGGCTAAGCAGAAAATC
CTCCAAGCGGAAGTCAACCTCGAGGTGGATGTGGTAGACAGCAAGCCAGAGACCCCTGACCTGGAGCAGCTGGAGCCGTCTTTGGAAGAT
GTGGAAAGCATGAATGATTTTGATCCCTTGTTTTCAGAGGAAACACCTGGAGTGGAGAAGCCGGTCACCACTGTTCAGCCCGTGTTTAAC
TTGGCAGCATATCATCAGCTATTTGTTGGGACAGAAAGAATTCGAGCTCCAGAGATTATTTTCCAGCCATCTCTCATAGGAGAAGAACAG
GCTGGGATTGCAGAGACTCTTCAGTACATTCTGGACAGGTACCCAAAGGACATTCAGGAAATGCTGGTTCAGAACGTTTTCCTCACTGGC
GGCAACACGATGTATCCTGGCATGAAAGCCAGAATGGAGAAGGAACTGTTGGAGATGAGACCCTTCCGGTCTTCTTTTCAGGTTCAACTT
GCCTCGAACCCTGTGCTGGATGCCTGGTACGGTGCTCGTGACTGGGCCTTGAACCACCTAGATGATAATGAAGTTTGGATCACCAGGAAA
GAGTATGAAGAAAAGGGAGGAGAGTACCTCAAGGAGCACTGTGCTTCCAACATCTATGTCCCCATCCGCCTGCCGAAGCAGGCCTCCCGC
TCCTCAGATGCCCAGGCATCCAGCAAGGGCTCCGCTGCTGGTGGAGGTGGTGCTGGTGAGCAGGCATAGCAGAGGCCCTCCAGAGAGACT
GCCCTGCACGCCATGCCTTGGGCCACGTTGGCAGTGTGACAGGACTGTGATTGTGCTAGATGTACCTGCCCAAGTCTGCTGGTCACATTT
GGCAGCAAAATGGATTTCTCCTGGGGAGAACAAAGTTAAGGGACACTGAGACCTGCCCTTCAGAATTCGGTTCACTTGGGGGCTTCTGTG
GTAGAGACTAACTGGCCTTCTGATGTCTTTGTTCAACTGTGGCCAGCTGTGGCATCAGCTTCCTGGAGCAGTAAATGAAGACAGAGTGGA

>57729_57729_2_NCOA3-ACTR5_NCOA3_chr20_46256767_ENST00000371997_ACTR5_chr20_37383599_ENST00000243903_length(amino acids)=623AA_BP=274
MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTIS
NDDDVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNLPKSTVNG
VSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMMEEGEDLQSCMICVARRITTGERTFPSNPESFITR
HDLSELHKWRCPDYYENNVHKMQLPFSSKLLGSTLTSEEKQERRQQQLRRLQELNARRREEKLQLDQERLDRLLYVQELLEDGQMDQFHK
ALIELNMDSPEELQSYIQKLSIAVEQAKQKILQAEVNLEVDVVDSKPETPDLEQLEPSLEDVESMNDFDPLFSEETPGVEKPVTTVQPVF
NLAAYHQLFVGTERIRAPEIIFQPSLIGEEQAGIAETLQYILDRYPKDIQEMLVQNVFLTGGNTMYPGMKARMEKELLEMRPFRSSFQVQ

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>57729_57729_3_NCOA3-ACTR5_NCOA3_chr20_46256767_ENST00000371998_ACTR5_chr20_37383599_ENST00000243903_length(transcript)=2438nt_BP=1014nt
CTGCGGCTTAGTCGGTGGCGGCCGGCGGCGGCTGCGGGCTGAGCGGCGAGTTTCCGATTTAAAGCTGAGCTGCGAGGAAAATGGCGGCGG
GAGGATCAAAATACTTGCTGGATGGTGGACTCAGAGACCAATAAAAATAAACTGCTTGAACATCCTTTGACTGGTTAGCCAGTTGCTGAT
GTATATTCAAGATGAGTGGATTAGGAGAAAACTTGGATCCACTGGCCAGTGATTCACGAAAACGCAAATTGCCATGTGATACTCCAGGAC
AAGGTCTTACCTGCAGTGGTGAAAAACGGAGACGGGAGCAGGAAAGTAAATATATTGAAGAATTGGCTGAGCTGATATCTGCCAATCTTA
GTGATATTGACAATTTCAATGTCAAACCAGATAAATGTGCGATTTTAAAGGAAACAGTAAGACAGATACGTCAAATAAAAGAGCAAGGAA
AAACTATTTCCAATGATGATGATGTTCAAAAAGCCGATGTATCTTCTACAGGGCAGGGAGTTATTGATAAAGACTCCTTAGGACCGCTTT
TACTTCAGGCATTGGATGGTTTCCTATTTGTGGTGAATCGAGACGGAAACATTGTATTTGTATCAGAAAATGTCACACAATACCTGCAAT
ATAAGCAAGAGGACCTGGTTAACACAAGTGTTTACAATATCTTACATGAAGAAGACAGAAAGGATTTTCTTAAGAATTTACCAAAATCTA
CAGTTAATGGAGTTTCCTGGACAAATGAGACCCAAAGACAAAAAAGCCATACATTTAATTGCCGTATGTTGATGAAAACACCACATGATA
TTCTGGAAGACATAAACGCCAGTCCTGAAATGCGCCAGAGATATGAAACAATGCAGTGCTTTGCCCTGTCTCAGCCACGAGCTATGATGG
AGGAAGGGGAAGATTTGCAATCTTGTATGATCTGTGTGGCACGCCGCATTACTACAGGAGAAAGAACATTTCCATCAAACCCTGAGAGCT
TTATTACCAGACATGATCTTTCAGAATTACACAAATGGCGGTGTCCTGATTATTATGAGAATAATGTCCACAAGATGCAGCTCCCATTTT
CCAGCAAGCTCCTGGGCAGCACTCTGACCTCTGAGGAGAAACAAGAAAGGCGGCAGCAGCAATTGCGGCGGCTGCAGGAGCTCAATGCCC
GGCGGCGGGAGGAGAAGCTGCAGCTGGATCAGGAGCGTCTGGACCGACTGCTATATGTGCAGGAACTTCTAGAGGATGGCCAGATGGATC
AGTTTCACAAAGCTCTGATAGAGCTGAATATGGACTCCCCAGAAGAGCTGCAGTCCTACATCCAGAAGCTCAGTATAGCAGTGGAGCAGG
CTAAGCAGAAAATCCTCCAAGCGGAAGTCAACCTCGAGGTGGATGTGGTAGACAGCAAGCCAGAGACCCCTGACCTGGAGCAGCTGGAGC
CGTCTTTGGAAGATGTGGAAAGCATGAATGATTTTGATCCCTTGTTTTCAGAGGAAACACCTGGAGTGGAGAAGCCGGTCACCACTGTTC
AGCCCGTGTTTAACTTGGCAGCATATCATCAGCTATTTGTTGGGACAGAAAGAATTCGAGCTCCAGAGATTATTTTCCAGCCATCTCTCA
TAGGAGAAGAACAGGCTGGGATTGCAGAGACTCTTCAGTACATTCTGGACAGGTACCCAAAGGACATTCAGGAAATGCTGGTTCAGAACG
TTTTCCTCACTGGCGGCAACACGATGTATCCTGGCATGAAAGCCAGAATGGAGAAGGAACTGTTGGAGATGAGACCCTTCCGGTCTTCTT
TTCAGGTTCAACTTGCCTCGAACCCTGTGCTGGATGCCTGGTACGGTGCTCGTGACTGGGCCTTGAACCACCTAGATGATAATGAAGTTT
GGATCACCAGGAAAGAGTATGAAGAAAAGGGAGGAGAGTACCTCAAGGAGCACTGTGCTTCCAACATCTATGTCCCCATCCGCCTGCCGA
AGCAGGCCTCCCGCTCCTCAGATGCCCAGGCATCCAGCAAGGGCTCCGCTGCTGGTGGAGGTGGTGCTGGTGAGCAGGCATAGCAGAGGC
CCTCCAGAGAGACTGCCCTGCACGCCATGCCTTGGGCCACGTTGGCAGTGTGACAGGACTGTGATTGTGCTAGATGTACCTGCCCAAGTC
TGCTGGTCACATTTGGCAGCAAAATGGATTTCTCCTGGGGAGAACAAAGTTAAGGGACACTGAGACCTGCCCTTCAGAATTCGGTTCACT
TGGGGGCTTCTGTGGTAGAGACTAACTGGCCTTCTGATGTCTTTGTTCAACTGTGGCCAGCTGTGGCATCAGCTTCCTGGAGCAGTAAAT
GAAGACAGAGTGGAGGACACAAATGTACAAAATGCACAAGACTGATTTCTTACCACATTTTAGTCTTTCTTGTTTTAAAAAAAATTCTTT

>57729_57729_3_NCOA3-ACTR5_NCOA3_chr20_46256767_ENST00000371998_ACTR5_chr20_37383599_ENST00000243903_length(amino acids)=623AA_BP=274
MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTIS
NDDDVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNLPKSTVNG
VSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMMEEGEDLQSCMICVARRITTGERTFPSNPESFITR
HDLSELHKWRCPDYYENNVHKMQLPFSSKLLGSTLTSEEKQERRQQQLRRLQELNARRREEKLQLDQERLDRLLYVQELLEDGQMDQFHK
ALIELNMDSPEELQSYIQKLSIAVEQAKQKILQAEVNLEVDVVDSKPETPDLEQLEPSLEDVESMNDFDPLFSEETPGVEKPVTTVQPVF
NLAAYHQLFVGTERIRAPEIIFQPSLIGEEQAGIAETLQYILDRYPKDIQEMLVQNVFLTGGNTMYPGMKARMEKELLEMRPFRSSFQVQ

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>57729_57729_4_NCOA3-ACTR5_NCOA3_chr20_46256767_ENST00000372004_ACTR5_chr20_37383599_ENST00000243903_length(transcript)=2463nt_BP=1039nt
AGCCGCTCCACAGCGACGGCAGCGGCTGCGGCTTAGTCGGTGGCGGCCGGCGGCGGCTGCGGGCTGAGCGGCGAGTTTCCGATTTAAAGC
TGAGCTGCGAGGAAAATGGCGGCGGGAGGATCAAAATACTTGCTGGATGGTGGACTCAGAGACCAATAAAAATAAACTGCTTGAACATCC
TTTGACTGGTTAGCCAGTTGCTGATGTATATTCAAGATGAGTGGATTAGGAGAAAACTTGGATCCACTGGCCAGTGATTCACGAAAACGC
AAATTGCCATGTGATACTCCAGGACAAGGTCTTACCTGCAGTGGTGAAAAACGGAGACGGGAGCAGGAAAGTAAATATATTGAAGAATTG
GCTGAGCTGATATCTGCCAATCTTAGTGATATTGACAATTTCAATGTCAAACCAGATAAATGTGCGATTTTAAAGGAAACAGTAAGACAG
ATACGTCAAATAAAAGAGCAAGGAAAAACTATTTCCAATGATGATGATGTTCAAAAAGCCGATGTATCTTCTACAGGGCAGGGAGTTATT
GATAAAGACTCCTTAGGACCGCTTTTACTTCAGGCATTGGATGGTTTCCTATTTGTGGTGAATCGAGACGGAAACATTGTATTTGTATCA
GAAAATGTCACACAATACCTGCAATATAAGCAAGAGGACCTGGTTAACACAAGTGTTTACAATATCTTACATGAAGAAGACAGAAAGGAT
TTTCTTAAGAATTTACCAAAATCTACAGTTAATGGAGTTTCCTGGACAAATGAGACCCAAAGACAAAAAAGCCATACATTTAATTGCCGT
ATGTTGATGAAAACACCACATGATATTCTGGAAGACATAAACGCCAGTCCTGAAATGCGCCAGAGATATGAAACAATGCAGTGCTTTGCC
CTGTCTCAGCCACGAGCTATGATGGAGGAAGGGGAAGATTTGCAATCTTGTATGATCTGTGTGGCACGCCGCATTACTACAGGAGAAAGA
ACATTTCCATCAAACCCTGAGAGCTTTATTACCAGACATGATCTTTCAGAATTACACAAATGGCGGTGTCCTGATTATTATGAGAATAAT
GTCCACAAGATGCAGCTCCCATTTTCCAGCAAGCTCCTGGGCAGCACTCTGACCTCTGAGGAGAAACAAGAAAGGCGGCAGCAGCAATTG
CGGCGGCTGCAGGAGCTCAATGCCCGGCGGCGGGAGGAGAAGCTGCAGCTGGATCAGGAGCGTCTGGACCGACTGCTATATGTGCAGGAA
CTTCTAGAGGATGGCCAGATGGATCAGTTTCACAAAGCTCTGATAGAGCTGAATATGGACTCCCCAGAAGAGCTGCAGTCCTACATCCAG
AAGCTCAGTATAGCAGTGGAGCAGGCTAAGCAGAAAATCCTCCAAGCGGAAGTCAACCTCGAGGTGGATGTGGTAGACAGCAAGCCAGAG
ACCCCTGACCTGGAGCAGCTGGAGCCGTCTTTGGAAGATGTGGAAAGCATGAATGATTTTGATCCCTTGTTTTCAGAGGAAACACCTGGA
GTGGAGAAGCCGGTCACCACTGTTCAGCCCGTGTTTAACTTGGCAGCATATCATCAGCTATTTGTTGGGACAGAAAGAATTCGAGCTCCA
GAGATTATTTTCCAGCCATCTCTCATAGGAGAAGAACAGGCTGGGATTGCAGAGACTCTTCAGTACATTCTGGACAGGTACCCAAAGGAC
ATTCAGGAAATGCTGGTTCAGAACGTTTTCCTCACTGGCGGCAACACGATGTATCCTGGCATGAAAGCCAGAATGGAGAAGGAACTGTTG
GAGATGAGACCCTTCCGGTCTTCTTTTCAGGTTCAACTTGCCTCGAACCCTGTGCTGGATGCCTGGTACGGTGCTCGTGACTGGGCCTTG
AACCACCTAGATGATAATGAAGTTTGGATCACCAGGAAAGAGTATGAAGAAAAGGGAGGAGAGTACCTCAAGGAGCACTGTGCTTCCAAC
ATCTATGTCCCCATCCGCCTGCCGAAGCAGGCCTCCCGCTCCTCAGATGCCCAGGCATCCAGCAAGGGCTCCGCTGCTGGTGGAGGTGGT
GCTGGTGAGCAGGCATAGCAGAGGCCCTCCAGAGAGACTGCCCTGCACGCCATGCCTTGGGCCACGTTGGCAGTGTGACAGGACTGTGAT
TGTGCTAGATGTACCTGCCCAAGTCTGCTGGTCACATTTGGCAGCAAAATGGATTTCTCCTGGGGAGAACAAAGTTAAGGGACACTGAGA
CCTGCCCTTCAGAATTCGGTTCACTTGGGGGCTTCTGTGGTAGAGACTAACTGGCCTTCTGATGTCTTTGTTCAACTGTGGCCAGCTGTG
GCATCAGCTTCCTGGAGCAGTAAATGAAGACAGAGTGGAGGACACAAATGTACAAAATGCACAAGACTGATTTCTTACCACATTTTAGTC

>57729_57729_4_NCOA3-ACTR5_NCOA3_chr20_46256767_ENST00000372004_ACTR5_chr20_37383599_ENST00000243903_length(amino acids)=623AA_BP=274
MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTIS
NDDDVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNLPKSTVNG
VSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMMEEGEDLQSCMICVARRITTGERTFPSNPESFITR
HDLSELHKWRCPDYYENNVHKMQLPFSSKLLGSTLTSEEKQERRQQQLRRLQELNARRREEKLQLDQERLDRLLYVQELLEDGQMDQFHK
ALIELNMDSPEELQSYIQKLSIAVEQAKQKILQAEVNLEVDVVDSKPETPDLEQLEPSLEDVESMNDFDPLFSEETPGVEKPVTTVQPVF
NLAAYHQLFVGTERIRAPEIIFQPSLIGEEQAGIAETLQYILDRYPKDIQEMLVQNVFLTGGNTMYPGMKARMEKELLEMRPFRSSFQVQ

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Fusion Gene PPI Analysis for NCOA3-ACTR5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNCOA3chr20:46256767chr20:37383599ENST00000371997+8231023_1093274.33333333333331416.0CREBBP
HgeneNCOA3chr20:46256767chr20:37383599ENST00000371998+8231023_1093274.33333333333331425.0CREBBP
HgeneNCOA3chr20:46256767chr20:37383599ENST00000372004+8231023_1093274.33333333333331421.0CREBBP


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NCOA3-ACTR5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NCOA3-ACTR5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCOA3C0023418leukemia2CTD_human
HgeneNCOA3C0033578Prostatic Neoplasms2CTD_human
HgeneNCOA3C0376358Malignant neoplasm of prostate2CTD_human
HgeneNCOA3C0001418Adenocarcinoma1CTD_human
HgeneNCOA3C0004114Astrocytoma1CTD_human
HgeneNCOA3C0005967Bone neoplasms1CTD_human
HgeneNCOA3C0006142Malignant neoplasm of breast1CTD_human
HgeneNCOA3C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneNCOA3C0007137Squamous cell carcinoma1CTD_human
HgeneNCOA3C0205641Adenocarcinoma, Basal Cell1CTD_human
HgeneNCOA3C0205642Adenocarcinoma, Oxyphilic1CTD_human
HgeneNCOA3C0205643Carcinoma, Cribriform1CTD_human
HgeneNCOA3C0205644Carcinoma, Granular Cell1CTD_human
HgeneNCOA3C0205645Adenocarcinoma, Tubular1CTD_human
HgeneNCOA3C0205768Subependymal Giant Cell Astrocytoma1CTD_human
HgeneNCOA3C0279530Malignant Bone Neoplasm1CTD_human
HgeneNCOA3C0280783Juvenile Pilocytic Astrocytoma1CTD_human
HgeneNCOA3C0280785Diffuse Astrocytoma1CTD_human
HgeneNCOA3C0334579Anaplastic astrocytoma1CTD_human
HgeneNCOA3C0334580Protoplasmic astrocytoma1CTD_human
HgeneNCOA3C0334581Gemistocytic astrocytoma1CTD_human
HgeneNCOA3C0334582Fibrillary Astrocytoma1CTD_human
HgeneNCOA3C0334583Pilocytic Astrocytoma1CTD_human
HgeneNCOA3C0338070Childhood Cerebral Astrocytoma1CTD_human
HgeneNCOA3C0547065Mixed oligoastrocytoma1CTD_human
HgeneNCOA3C0678222Breast Carcinoma1CTD_human
HgeneNCOA3C0750935Cerebral Astrocytoma1CTD_human
HgeneNCOA3C0750936Intracranial Astrocytoma1CTD_human
HgeneNCOA3C1257931Mammary Neoplasms, Human1CTD_human
HgeneNCOA3C1458155Mammary Neoplasms1CTD_human
HgeneNCOA3C1704230Grade I Astrocytoma1CTD_human
HgeneNCOA3C4704874Mammary Carcinoma, Human1CTD_human