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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CASP8-CFLAR (FusionGDB2 ID:HG841TG8837)

Fusion Gene Summary for CASP8-CFLAR

Fusion gene summary

Fusion gene information	Fusion gene name: CASP8-CFLAR
	Fusion gene ID: hg841tg8837
		Hgene	Tgene
	Gene symbol	CASP8	CFLAR
	Gene ID	841	8837
	Gene name	caspase 8	CASP8 and FADD like apoptosis regulator
	Synonyms	ALPS2B\|CAP4\|Casp-8\|FLICE\|MACH\|MCH5	CASH\|CASP8AP1\|CLARP\|Casper\|FLAME\|FLAME-1\|FLAME1\|FLIP\|I-FLICE\|MRIT\|c-FLIP\|c-FLIPL\|c-FLIPR\|c-FLIPS\|cFLIP
	Cytomap	('CASP8')('CFLAR') 2q33.1	2q33.1
	Type of gene	protein-coding	protein-coding
	Description	caspase-8FADD-homologous ICE/CED-3-like proteaseFADD-like ICEICE-like apoptotic protease 5MACH-alpha-1/2/3 proteinMACH-beta-1/2/3/4 proteinMORT1-associated ced-3 homologapoptotic cysteine proteaseapoptotic protease Mch-5caspase 8, apoptosis-relat	CASP8 and FADD-like apoptosis regulatorFADD-like antiapoptotic molecule 1MACH-related inducer of toxicitycaspase homologcaspase-eight-related proteincaspase-like apoptosis regulatory proteincaspase-related inducer of apoptosiscellular FLICE-like in
	Modification date	20200322	20200322
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000490682, ENST00000264274, ENST00000264275, ENST00000392258, ENST00000392259, ENST00000392266, ENST00000432109, ENST00000323492, ENST00000358485,
Fusion gene scores	* DoF score	10 X 7 X 10=700	10 X 11 X 6=660
	# samples	12	14
	** MAII score	log2(12/700*10)=-2.54432051622381 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/660*10)=-2.23703919730085 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CASP8 [Title/Abstract] AND CFLAR [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CASP8(202098835)-CFLAR(201994452), # samples:4
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CASP8	GO:0006508	proteolysis	12888622
Hgene	CASP8	GO:0036462	TRAIL-activated apoptotic signaling pathway	21785459
Hgene	CASP8	GO:0045862	positive regulation of proteolysis	18387192
Hgene	CASP8	GO:0097191	extrinsic apoptotic signaling pathway	21785459
Hgene	CASP8	GO:0097202	activation of cysteine-type endopeptidase activity	18387192
Tgene	CFLAR	GO:0060544	regulation of necroptotic process	21737330
Tgene	CFLAR	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	26582200
Tgene	CFLAR	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	9208847

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-BH-A18T-01A	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
ChimerDB4	SKCM	TCGA-WE-A8K4-01A	CASP8	chr2	202098835	-	CFLAR	chr2	201994452	+
ChimerDB4	SKCM	TCGA-WE-A8K4-01A	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
ChimerDB4	STAD	TCGA-BR-8361-01A	CASP8	chr2	202098835	-	CFLAR	chr2	201994452	+

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Fusion Gene ORF analysis for CASP8-CFLAR

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-5UTR	ENST00000490682	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-5UTR	ENST00000490682	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-5UTR	ENST00000490682	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-5UTR	ENST00000490682	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-5UTR	ENST00000490682	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-5UTR	ENST00000490682	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-5UTR	ENST00000490682	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-5UTR	ENST00000490682	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-5UTR	ENST00000490682	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-intron	ENST00000490682	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-intron	ENST00000490682	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-intron	ENST00000490682	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-intron	ENST00000490682	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-intron	ENST00000490682	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264274	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264274	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264274	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264274	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264274	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264275	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264275	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264275	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264275	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264275	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392258	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392258	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392258	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392258	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392258	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392259	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392259	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392259	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392259	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392259	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392266	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392266	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392266	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392266	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392266	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000432109	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000432109	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000432109	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000432109	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000432109	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000323492	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000323492	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000323492	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000323492	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000323492	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000358485	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000358485	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000358485	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000358485	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000358485	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for CASP8-CFLAR

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CASP8	chr2	202098835	+	CFLAR	chr2	201994451	+	5.08E-07	0.9999995
CASP8	chr2	202098835	+	CFLAR	chr2	201994451	+	5.08E-07	0.9999995

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CASP8-CFLAR

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:202098835/:201994452)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for CASP8-CFLAR

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CASP8-CFLAR

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CASP8-CFLAR

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CASP8-CFLAR

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CASP8	C0006142	Malignant neoplasm of breast	4	CGI;CTD_human
Hgene	CASP8	C0678222	Breast Carcinoma	4	CGI;CTD_human
Hgene	CASP8	C1257931	Mammary Neoplasms, Human	4	CTD_human
Hgene	CASP8	C1458155	Mammary Neoplasms	4	CTD_human
Hgene	CASP8	C4704874	Mammary Carcinoma, Human	4	CTD_human
Hgene	CASP8	C1846545	Autoimmune Lymphoproliferative Syndrome Type 2B	3	CTD_human;ORPHANET;UNIPROT
Hgene	CASP8	C0014859	Esophageal Neoplasms	2	CTD_human
Hgene	CASP8	C0025202	melanoma	2	CTD_human
Hgene	CASP8	C0546837	Malignant neoplasm of esophagus	2	CTD_human
Hgene	CASP8	C0001418	Adenocarcinoma	1	CTD_human
Hgene	CASP8	C0005586	Bipolar Disorder	1	PSYGENET
Hgene	CASP8	C0007114	Malignant neoplasm of skin	1	CTD_human
Hgene	CASP8	C0007131	Non-Small Cell Lung Carcinoma	1	CTD_human
Hgene	CASP8	C0007873	Uterine Cervical Neoplasm	1	CTD_human
Hgene	CASP8	C0009402	Colorectal Carcinoma	1	CTD_human
Hgene	CASP8	C0009404	Colorectal Neoplasms	1	CTD_human
Hgene	CASP8	C0011616	Contact Dermatitis	1	CTD_human
Hgene	CASP8	C0011860	Diabetes Mellitus, Non-Insulin-Dependent	1	CTD_human
Hgene	CASP8	C0013604	Edema	1	CTD_human
Hgene	CASP8	C0023452	Childhood Acute Lymphoblastic Leukemia	1	CTD_human
Hgene	CASP8	C0023453	L2 Acute Lymphoblastic Leukemia	1	CTD_human
Hgene	CASP8	C0024121	Lung Neoplasms	1	CTD_human
Hgene	CASP8	C0024623	Malignant neoplasm of stomach	1	CTD_human
Hgene	CASP8	C0027055	Myocardial Reperfusion Injury	1	CTD_human
Hgene	CASP8	C0035126	Reperfusion Injury	1	CTD_human
Hgene	CASP8	C0037286	Skin Neoplasms	1	CTD_human
Hgene	CASP8	C0038220	Status Epilepticus	1	CTD_human
Hgene	CASP8	C0038356	Stomach Neoplasms	1	CTD_human
Hgene	CASP8	C0151603	Anasarca	1	CTD_human
Hgene	CASP8	C0162351	Contact hypersensitivity	1	CTD_human
Hgene	CASP8	C0162820	Dermatitis, Allergic Contact	1	CTD_human
Hgene	CASP8	C0205641	Adenocarcinoma, Basal Cell	1	CTD_human
Hgene	CASP8	C0205642	Adenocarcinoma, Oxyphilic	1	CTD_human
Hgene	CASP8	C0205643	Carcinoma, Cribriform	1	CTD_human
Hgene	CASP8	C0205644	Carcinoma, Granular Cell	1	CTD_human
Hgene	CASP8	C0205645	Adenocarcinoma, Tubular	1	CTD_human
Hgene	CASP8	C0242379	Malignant neoplasm of lung	1	CTD_human
Hgene	CASP8	C0270823	Petit mal status	1	CTD_human
Hgene	CASP8	C0279607	Adult Hepatocellular Carcinoma	1	ORPHANET
Hgene	CASP8	C0311335	Grand Mal Status Epilepticus	1	CTD_human
Hgene	CASP8	C0343641	Human papilloma virus infection	1	CTD_human
Hgene	CASP8	C0393734	Complex Partial Status Epilepticus	1	CTD_human
Hgene	CASP8	C0751522	Status Epilepticus, Subclinical	1	CTD_human
Hgene	CASP8	C0751523	Non-Convulsive Status Epilepticus	1	CTD_human
Hgene	CASP8	C0751524	Simple Partial Status Epilepticus	1	CTD_human
Hgene	CASP8	C1168401	Squamous cell carcinoma of the head and neck	1	CTD_human
Hgene	CASP8	C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human
Hgene	CASP8	C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	1	CTD_human
Hgene	CASP8	C2931456	Prostate cancer, familial	1	CTD_human
Hgene	CASP8	C2937358	Cerebral Hemorrhage	1	CTD_human
Hgene	CASP8	C4048328	cervical cancer	1	CTD_human
Hgene	CASP8	C4722327	PROSTATE CANCER, HEREDITARY, 1	1	CTD_human
Tgene		C0019829	Hodgkin Disease	1	CTD_human
Tgene		C0023418	leukemia	1	CTD_human
Tgene		C0030297	Pancreatic Neoplasm	1	CTD_human
Tgene		C0152266	Mixed Cellularity Hodgkin Lymphoma	1	CTD_human
Tgene		C0152267	Hodgkin lymphoma, lymphocyte depletion	1	CTD_human
Tgene		C0220597	Adult Hodgkin Lymphoma	1	CTD_human
Tgene		C0346647	Malignant neoplasm of pancreas	1	CTD_human
Tgene		C0392788	Nasal Type Extranodal NK/T-Cell Lymphoma	1	CTD_human
Tgene		C1266194	Lymphocyte Rich Classical Hodgkin Lymphoma	1	CTD_human
Tgene		C1334968	Nodular Lymphocyte Predominant Hodgkin Lymphoma	1	CTD_human
Tgene		C1955906	Lymphoma, Extranodal NK-T-Cell	1	CTD_human
Tgene		C2713368	Hematopoetic Myelodysplasia	1	CTD_human
Tgene		C3463824	MYELODYSPLASTIC SYNDROME	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:CASP8-CFLAR (FusionGDB2 ID:HG841TG8837)

Fusion Gene Summary for CASP8-CFLAR

Fusion Gene ORF analysis for CASP8-CFLAR

Fusion Genomic Features for CASP8-CFLAR

Fusion Protein Features for CASP8-CFLAR

Fusion Gene Sequence for CASP8-CFLAR

Fusion Gene PPI Analysis for CASP8-CFLAR

Related Drugs for CASP8-CFLAR

Related Diseases for CASP8-CFLAR

Fusion Gene Studies
in Kim Lab