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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TOX2-EIF5A (FusionGDB2 ID:HG84969TG1984)

Fusion Gene Summary for TOX2-EIF5A

Fusion gene summary

Fusion gene information	Fusion gene name: TOX2-EIF5A
	Fusion gene ID: hg84969tg1984
		Hgene	Tgene
	Gene symbol	TOX2	EIF5A
	Gene ID	84969	1984
	Gene name	TOX high mobility group box family member 2	eukaryotic translation initiation factor 5A
	Synonyms	C20orf100\|GCX-1\|GCX1\|dJ1108D11.2\|dJ495O3.1	EIF-5A\|EIF5A1\|eIF-4D\|eIF5AI
	Cytomap	('TOX2')('EIF5A') 20q13.12	17p13.1
	Type of gene	protein-coding	protein-coding
	Description	TOX high mobility group box family member 2granulosa cell HMG box 1	eukaryotic translation initiation factor 5A-1eukaryotic initiation factor 5Arev-binding factor
	Modification date	20200313	20200313
	UniProtAcc	.	P63241
	Ensembl transtripts involved in fusion gene	ENST00000341197, ENST00000358131, ENST00000372999, ENST00000423191, ENST00000435864,
Fusion gene scores	* DoF score	5 X 5 X 3=75	9 X 5 X 8=360
	# samples	5	9
	** MAII score	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/360*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TOX2 [Title/Abstract] AND EIF5A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TOX2(42635432)-EIF5A(7212934), # samples:1
Anticipated loss of major functional domain due to fusion event.	TOX2-EIF5A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TOX2-EIF5A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TOX2-EIF5A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TOX2-EIF5A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TOX2	GO:0045944	positive regulation of transcription by RNA polymerase II	25352127
Tgene	EIF5A	GO:0006913	nucleocytoplasmic transport	12210765
Tgene	EIF5A	GO:0006915	apoptotic process	15371445\|17187778

Fusion gene breakpoints across TOX2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EIF5A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-J4-A67N-01A	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+

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Fusion Gene ORF analysis for TOX2-EIF5A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000341197	ENST00000336458	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000341197	ENST00000416016	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000341197	ENST00000419711	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000341197	ENST00000571955	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000341197	ENST00000572815	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000341197	ENST00000573542	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000341197	ENST00000576930	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000358131	ENST00000336458	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000358131	ENST00000416016	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000358131	ENST00000419711	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000358131	ENST00000571955	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000358131	ENST00000572815	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000358131	ENST00000573542	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000358131	ENST00000576930	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000372999	ENST00000336458	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000372999	ENST00000416016	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000372999	ENST00000419711	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000372999	ENST00000571955	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000372999	ENST00000572815	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000372999	ENST00000573542	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000372999	ENST00000576930	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000423191	ENST00000336458	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000423191	ENST00000416016	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000423191	ENST00000419711	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000423191	ENST00000571955	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000423191	ENST00000572815	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000423191	ENST00000573542	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
5CDS-5UTR	ENST00000423191	ENST00000576930	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
In-frame	ENST00000341197	ENST00000336452	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
In-frame	ENST00000358131	ENST00000336452	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
In-frame	ENST00000372999	ENST00000336452	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
In-frame	ENST00000423191	ENST00000336452	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
intron-3CDS	ENST00000435864	ENST00000336452	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
intron-5UTR	ENST00000435864	ENST00000336458	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
intron-5UTR	ENST00000435864	ENST00000416016	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
intron-5UTR	ENST00000435864	ENST00000419711	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
intron-5UTR	ENST00000435864	ENST00000571955	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
intron-5UTR	ENST00000435864	ENST00000572815	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
intron-5UTR	ENST00000435864	ENST00000573542	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+
intron-5UTR	ENST00000435864	ENST00000576930	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000341197

TOX2

chr20

42635432

ENST00000336452

EIF5A

chr17

7212934

1570

439

924

298

ENST00000423191

TOX2

chr20

42635432

ENST00000336452

EIF5A

chr17

7212934

1502

371

856

256

ENST00000372999

TOX2

chr20

42635432

ENST00000336452

EIF5A

chr17

7212934

1610

479

140

964

274

ENST00000358131

TOX2

chr20

42635432

ENST00000336452

EIF5A

chr17

7212934

1777

646

169

1131

320

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000341197	ENST00000336452	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+	0.001130666	0.99886936
ENST00000423191	ENST00000336452	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+	0.006505524	0.99349445
ENST00000372999	ENST00000336452	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+	0.006356164	0.9936439
ENST00000358131	ENST00000336452	TOX2	chr20	42635432	+	EIF5A	chr17	7212934	+	0.003068025	0.9969319

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Fusion Genomic Features for TOX2-EIF5A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TOX2	chr20	42635432	+	EIF5A	chr17	7212933	+	5.09E-08	1
TOX2	chr20	42635432	+	EIF5A	chr17	7212933	+	5.09E-08	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TOX2-EIF5A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:42635432/chr17:7212934)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	EIF5A P63241
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts. {ECO:0000269\|PubMed:15371445, ECO:0000269\|PubMed:15452064, ECO:0000269\|PubMed:16987817, ECO:0000269\|PubMed:17187778, ECO:0000269\|PubMed:17360499}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TOX2

chr20:42635432

chr17:7212934

ENST00000341197

76_114

137

507.0

Region

Required for transcriptional activation

Hgene

TOX2

chr20:42635432

chr17:7212934

ENST00000358131

76_114

146

489.0

Region

Required for transcriptional activation

Tgene

EIF5A

chr20:42635432

chr17:7212934

ENST00000336452

20_90

357.3333333333333

Region

Note=DOHH-binding

Tgene

EIF5A

chr20:42635432

chr17:7212934

ENST00000336458

20_90

239.66666666666666

Region

Note=DOHH-binding

Tgene

EIF5A

chr20:42635432

chr17:7212934

ENST00000416016

20_90

298.0

Region

Note=DOHH-binding

Tgene

EIF5A

chr20:42635432

chr17:7212934

ENST00000419711

20_90

319.6666666666667

Region

Note=DOHH-binding

Tgene

EIF5A

chr20:42635432

chr17:7212934

ENST00000571955

20_90

319.6666666666667

Region

Note=DOHH-binding

Tgene

EIF5A

chr20:42635432

chr17:7212934

ENST00000573542

20_90

245.66666666666666

Region

Note=DOHH-binding

Tgene

EIF5A

chr20:42635432

chr17:7212934

ENST00000576930

20_90

295.3333333333333

Region

Note=DOHH-binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TOX2

chr20:42635432

chr17:7212934

ENST00000341197

245_250

137

507.0

Compositional bias

Note=Poly-Lys

Hgene

TOX2

chr20:42635432

chr17:7212934

ENST00000341197

372_456

137

507.0

Compositional bias

Note=Pro-rich

Hgene

TOX2

chr20:42635432

chr17:7212934

ENST00000358131

245_250

146

489.0

Compositional bias

Note=Poly-Lys

Hgene

TOX2

chr20:42635432

chr17:7212934

ENST00000358131

372_456

146

489.0

Compositional bias

Note=Pro-rich

Hgene

TOX2

chr20:42635432

chr17:7212934

ENST00000372999

245_250

465.0

Compositional bias

Note=Poly-Lys

Hgene

TOX2

chr20:42635432

chr17:7212934

ENST00000372999

372_456

465.0

Compositional bias

Note=Pro-rich

Hgene

TOX2

chr20:42635432

chr17:7212934

ENST00000423191

245_250

465.0

Compositional bias

Note=Poly-Lys

Hgene

TOX2

chr20:42635432

chr17:7212934

ENST00000423191

372_456

465.0

Compositional bias

Note=Pro-rich

Hgene

TOX2

chr20:42635432

chr17:7212934

ENST00000341197

255_323

137

507.0

DNA binding

HMG box

Hgene

TOX2

chr20:42635432

chr17:7212934

ENST00000358131

255_323

146

489.0

DNA binding

HMG box

Hgene

TOX2

chr20:42635432

chr17:7212934

ENST00000372999

255_323

465.0

DNA binding

HMG box

Hgene

TOX2

chr20:42635432

chr17:7212934

ENST00000423191

255_323

465.0

DNA binding

HMG box

Hgene

TOX2

chr20:42635432

chr17:7212934

ENST00000341197

223_252

137

507.0

Motif

Nuclear localization signal

Hgene

TOX2

chr20:42635432

chr17:7212934

ENST00000358131

223_252

146

489.0

Motif

Nuclear localization signal

Hgene

TOX2

chr20:42635432

chr17:7212934

ENST00000372999

223_252

465.0

Motif

Nuclear localization signal

Hgene

TOX2

chr20:42635432

chr17:7212934

ENST00000423191

223_252

465.0

Motif

Nuclear localization signal

Hgene

TOX2

chr20:42635432

chr17:7212934

ENST00000372999

76_114

465.0

Region

Required for transcriptional activation

Hgene

TOX2

chr20:42635432

chr17:7212934

ENST00000423191

76_114

465.0

Region

Required for transcriptional activation

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Fusion Gene Sequence for TOX2-EIF5A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>93149_93149_1_TOX2-EIF5A_TOX2_chr20_42635432_ENST00000341197_EIF5A_chr17_7212934_ENST00000336452_length(transcript)=1570nt_BP=439nt
AGCCGCCGCCGCCGCCGCCGCGCCCGCCATGGACGTCCGCCTGTACCCCTCGGCGCCCGCGGTGGGCGCGCGGCCCGGGGCCGAGCCGGC
CGGCCTGGCGCACCTGGACTATTACCACGGCGGCAAGTTTGATGGTGACAGTGCCTACGTGGGGATGAGTGACGGAAACCCAGAGCTCCT
GTCAACCAGCCAGACCTACAACGGCCAGAGCGAGAACAACGAAGACTATGAGATCCCCCCGATAACACCTCCCAACCTCCCGGAGCCATC
CCTCCTGCACCTGGGGGACCACGAAGCCAGCTACCACTCGCTGTGCCACGGCCTCACCCCCAACGGTCTGCTCCCTGCCTACTCCTATCA
GGCCATGGACCTCCCAGCCATCATGGTGTCCAACATGCTAGCACAGGACAGCCACCTGCTGTCGGGCCAGCTGCCCACGTTGGAATCGAA
GCCTCTTAAAATGGCAGATGACTTGGACTTCGAGACAGGAGATGCAGGGGCCTCAGCCACCTTCCCAATGCAGTGCTCAGCATTACGTAA
GAATGGCTTTGTGGTGCTCAAAGGCCGGCCATGTAAGATCGTCGAGATGTCTACTTCGAAGACTGGCAAGCACGGCCACGCCAAGGTCCA
TCTGGTTGGTATTGACATCTTTACTGGGAAGAAATATGAAGATATCTGCCCGTCAACTCATAATATGGATGTCCCCAACATCAAAAGGAA
TGACTTCCAGCTGATTGGCATCCAGGATGGGTACCTATCACTGCTCCAGGACAGCGGGGAGGTACGAGAGGACCTTCGTCTCCCTGAGGG
AGACCTTGGCAAGGAGATTGAGCAGAAGTACGACTGTGGAGAAGAGATCCTGATCACGGTGCTGTCTGCCATGACAGAGGAGGCAGCTGT
TGCAATCAAGGCCATGGCAAAATAACTGGCTCCCAGGGTGGCGGTGGTGGCAGCAGTGATCCTCTGAACCTGCAGAGGCCCCCTCCCCGA
GCCTGGCCTGGCTCTGGCCCGGTCCTAAGCTGGACTCCTCCTACACAATTTATTTGACGTTTTATTTTGGTTTTCCCCACCCCCTCAATC
TGTCGGGGAGCCCCTGCCCTTCACCTAGCTCCCTTGGCCAGGAGCGAGCGAAGCTGTGGCCTTGGTGAAGCTGCCCTCCTCTTCTCCCCT
CACACTACAGCCCTGGTGGGGGAGAAGGGGGTGGGTGCTGCTTGTGGTTTAGTCTTTTTTTTTTTTTTTTTTTTAATTCAATCTGGAATC
AGAAAGCGGTGGATTCTGGCAAATGGTCCTTGTGCCCTCCCCACTCATCCCTGGTCTGGTCCCCTGTTGCCTATAGCCCTTTACCCTGAG
CACCACCCCAACAGACTGGGGACCAGCCCCCTCGCCTGCCTGTGTCTCTCCCCAAACCCCTTTAGATGGGGAGGGAAGAGGAGGAGAGGG
GAGGGGACCTGCCCCCTCCTCAGGCATCTGGGAGGGCCCTGCCCCCATGGGCTTTACCCTTCCCTGCGGGCTCTCTCCCCGACACATTTG

>93149_93149_1_TOX2-EIF5A_TOX2_chr20_42635432_ENST00000341197_EIF5A_chr17_7212934_ENST00000336452_length(amino acids)=298AA_BP=137
MDVRLYPSAPAVGARPGAEPAGLAHLDYYHGGKFDGDSAYVGMSDGNPELLSTSQTYNGQSENNEDYEIPPITPPNLPEPSLLHLGDHEA
SYHSLCHGLTPNGLLPAYSYQAMDLPAIMVSNMLAQDSHLLSGQLPTLESKPLKMADDLDFETGDAGASATFPMQCSALRKNGFVVLKGR
PCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVREDLRLPEGDLGKEIEQK

--------------------------------------------------------------
>93149_93149_2_TOX2-EIF5A_TOX2_chr20_42635432_ENST00000358131_EIF5A_chr17_7212934_ENST00000336452_length(transcript)=1777nt_BP=646nt
ACCAGGAGCTCCGAACACGCAGGCCCAAATTGGAATAGGAGATGGATTTTGATAAAAGAGGTTAAATAACAGGTTTTTCCATTTCACCTT
ATACGAATGGGATGGGGGGTGGGGGTGCTGGGCCTCCAGCCAATAGAGGACCAAGAGTTGTCAGGAGGGCTTATAAAGCTTGCTATTTCT
GGCATTTTTTCCTCTTTCTCTGCTGATTATGCAGCAGACTCGCACAGAGGCTGTCGCGGGCGCGTTCTCTCGCTGCCTGGGCTTCTGTGG
AATGAGACTCGGGCTCCTTCTACTTGCAAGACACTGGTGCATTGCAGGTGTGTTTCCGCAGAAGTTTGATGGTGACAGTGCCTACGTGGG
GATGAGTGACGGAAACCCAGAGCTCCTGTCAACCAGCCAGACCTACAACGGCCAGAGCGAGAACAACGAAGACTATGAGATCCCCCCGAT
AACACCTCCCAACCTCCCGGAGCCATCCCTCCTGCACCTGGGGGACCACGAAGCCAGCTACCACTCGCTGTGCCACGGCCTCACCCCCAA
CGGTCTGCTCCCTGCCTACTCCTATCAGGCCATGGACCTCCCAGCCATCATGGTGTCCAACATGCTAGCACAGGACAGCCACCTGCTGTC
GGGCCAGCTGCCCACGTTGGAATCGAAGCCTCTTAAAATGGCAGATGACTTGGACTTCGAGACAGGAGATGCAGGGGCCTCAGCCACCTT
CCCAATGCAGTGCTCAGCATTACGTAAGAATGGCTTTGTGGTGCTCAAAGGCCGGCCATGTAAGATCGTCGAGATGTCTACTTCGAAGAC
TGGCAAGCACGGCCACGCCAAGGTCCATCTGGTTGGTATTGACATCTTTACTGGGAAGAAATATGAAGATATCTGCCCGTCAACTCATAA
TATGGATGTCCCCAACATCAAAAGGAATGACTTCCAGCTGATTGGCATCCAGGATGGGTACCTATCACTGCTCCAGGACAGCGGGGAGGT
ACGAGAGGACCTTCGTCTCCCTGAGGGAGACCTTGGCAAGGAGATTGAGCAGAAGTACGACTGTGGAGAAGAGATCCTGATCACGGTGCT
GTCTGCCATGACAGAGGAGGCAGCTGTTGCAATCAAGGCCATGGCAAAATAACTGGCTCCCAGGGTGGCGGTGGTGGCAGCAGTGATCCT
CTGAACCTGCAGAGGCCCCCTCCCCGAGCCTGGCCTGGCTCTGGCCCGGTCCTAAGCTGGACTCCTCCTACACAATTTATTTGACGTTTT
ATTTTGGTTTTCCCCACCCCCTCAATCTGTCGGGGAGCCCCTGCCCTTCACCTAGCTCCCTTGGCCAGGAGCGAGCGAAGCTGTGGCCTT
GGTGAAGCTGCCCTCCTCTTCTCCCCTCACACTACAGCCCTGGTGGGGGAGAAGGGGGTGGGTGCTGCTTGTGGTTTAGTCTTTTTTTTT
TTTTTTTTTTTAATTCAATCTGGAATCAGAAAGCGGTGGATTCTGGCAAATGGTCCTTGTGCCCTCCCCACTCATCCCTGGTCTGGTCCC
CTGTTGCCTATAGCCCTTTACCCTGAGCACCACCCCAACAGACTGGGGACCAGCCCCCTCGCCTGCCTGTGTCTCTCCCCAAACCCCTTT
AGATGGGGAGGGAAGAGGAGGAGAGGGGAGGGGACCTGCCCCCTCCTCAGGCATCTGGGAGGGCCCTGCCCCCATGGGCTTTACCCTTCC

>93149_93149_2_TOX2-EIF5A_TOX2_chr20_42635432_ENST00000358131_EIF5A_chr17_7212934_ENST00000336452_length(amino acids)=320AA_BP=159
MLFLAFFPLSLLIMQQTRTEAVAGAFSRCLGFCGMRLGLLLLARHWCIAGVFPQKFDGDSAYVGMSDGNPELLSTSQTYNGQSENNEDYE
IPPITPPNLPEPSLLHLGDHEASYHSLCHGLTPNGLLPAYSYQAMDLPAIMVSNMLAQDSHLLSGQLPTLESKPLKMADDLDFETGDAGA
SATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQD

--------------------------------------------------------------
>93149_93149_3_TOX2-EIF5A_TOX2_chr20_42635432_ENST00000372999_EIF5A_chr17_7212934_ENST00000336452_length(transcript)=1610nt_BP=479nt
CGCAGCCCTGGCGCAGACGCGTGGGCTCCGTGGCGATGCGGGGTGTTGCCTGAGGCTCCACTGAAGCTATGGCATAATTTGCAGAATTTG
CACTTCATTACTTTTCTGAAATTCAAACAAATTCTGAAACTGCACGAGTTCTGGCTGAGAGCTGTGGATCTGTGCATTTTGATGGTGACA
GTGCCTACGTGGGGATGAGTGACGGAAACCCAGAGCTCCTGTCAACCAGCCAGACCTACAACGGCCAGAGCGAGAACAACGAAGACTATG
AGATCCCCCCGATAACACCTCCCAACCTCCCGGAGCCATCCCTCCTGCACCTGGGGGACCACGAAGCCAGCTACCACTCGCTGTGCCACG
GCCTCACCCCCAACGGTCTGCTCCCTGCCTACTCCTATCAGGCCATGGACCTCCCAGCCATCATGGTGTCCAACATGCTAGCACAGGACA
GCCACCTGCTGTCGGGCCAGCTGCCCACGTTGGAATCGAAGCCTCTTAAAATGGCAGATGACTTGGACTTCGAGACAGGAGATGCAGGGG
CCTCAGCCACCTTCCCAATGCAGTGCTCAGCATTACGTAAGAATGGCTTTGTGGTGCTCAAAGGCCGGCCATGTAAGATCGTCGAGATGT
CTACTTCGAAGACTGGCAAGCACGGCCACGCCAAGGTCCATCTGGTTGGTATTGACATCTTTACTGGGAAGAAATATGAAGATATCTGCC
CGTCAACTCATAATATGGATGTCCCCAACATCAAAAGGAATGACTTCCAGCTGATTGGCATCCAGGATGGGTACCTATCACTGCTCCAGG
ACAGCGGGGAGGTACGAGAGGACCTTCGTCTCCCTGAGGGAGACCTTGGCAAGGAGATTGAGCAGAAGTACGACTGTGGAGAAGAGATCC
TGATCACGGTGCTGTCTGCCATGACAGAGGAGGCAGCTGTTGCAATCAAGGCCATGGCAAAATAACTGGCTCCCAGGGTGGCGGTGGTGG
CAGCAGTGATCCTCTGAACCTGCAGAGGCCCCCTCCCCGAGCCTGGCCTGGCTCTGGCCCGGTCCTAAGCTGGACTCCTCCTACACAATT
TATTTGACGTTTTATTTTGGTTTTCCCCACCCCCTCAATCTGTCGGGGAGCCCCTGCCCTTCACCTAGCTCCCTTGGCCAGGAGCGAGCG
AAGCTGTGGCCTTGGTGAAGCTGCCCTCCTCTTCTCCCCTCACACTACAGCCCTGGTGGGGGAGAAGGGGGTGGGTGCTGCTTGTGGTTT
AGTCTTTTTTTTTTTTTTTTTTTTAATTCAATCTGGAATCAGAAAGCGGTGGATTCTGGCAAATGGTCCTTGTGCCCTCCCCACTCATCC
CTGGTCTGGTCCCCTGTTGCCTATAGCCCTTTACCCTGAGCACCACCCCAACAGACTGGGGACCAGCCCCCTCGCCTGCCTGTGTCTCTC
CCCAAACCCCTTTAGATGGGGAGGGAAGAGGAGGAGAGGGGAGGGGACCTGCCCCCTCCTCAGGCATCTGGGAGGGCCCTGCCCCCATGG

>93149_93149_3_TOX2-EIF5A_TOX2_chr20_42635432_ENST00000372999_EIF5A_chr17_7212934_ENST00000336452_length(amino acids)=274AA_BP=113
MAESCGSVHFDGDSAYVGMSDGNPELLSTSQTYNGQSENNEDYEIPPITPPNLPEPSLLHLGDHEASYHSLCHGLTPNGLLPAYSYQAMD
LPAIMVSNMLAQDSHLLSGQLPTLESKPLKMADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVG
IDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVREDLRLPEGDLGKEIEQKYDCGEEILITVLSAMTEEAAVAIK

--------------------------------------------------------------
>93149_93149_4_TOX2-EIF5A_TOX2_chr20_42635432_ENST00000423191_EIF5A_chr17_7212934_ENST00000336452_length(transcript)=1502nt_BP=371nt
AGCGCGCGTGGGTTTCCCGCAGCCCTGGCGCAGACGCGTGGGCTCCGTGGCGATGCGGGTTTGATGGTGACAGTGCCTACGTGGGGATGA
GTGACGGAAACCCAGAGCTCCTGTCAACCAGCCAGACCTACAACGGCCAGAGCGAGAACAACGAAGACTATGAGATCCCCCCGATAACAC
CTCCCAACCTCCCGGAGCCATCCCTCCTGCACCTGGGGGACCACGAAGCCAGCTACCACTCGCTGTGCCACGGCCTCACCCCCAACGGTC
TGCTCCCTGCCTACTCCTATCAGGCCATGGACCTCCCAGCCATCATGGTGTCCAACATGCTAGCACAGGACAGCCACCTGCTGTCGGGCC
AGCTGCCCACGTTGGAATCGAAGCCTCTTAAAATGGCAGATGACTTGGACTTCGAGACAGGAGATGCAGGGGCCTCAGCCACCTTCCCAA
TGCAGTGCTCAGCATTACGTAAGAATGGCTTTGTGGTGCTCAAAGGCCGGCCATGTAAGATCGTCGAGATGTCTACTTCGAAGACTGGCA
AGCACGGCCACGCCAAGGTCCATCTGGTTGGTATTGACATCTTTACTGGGAAGAAATATGAAGATATCTGCCCGTCAACTCATAATATGG
ATGTCCCCAACATCAAAAGGAATGACTTCCAGCTGATTGGCATCCAGGATGGGTACCTATCACTGCTCCAGGACAGCGGGGAGGTACGAG
AGGACCTTCGTCTCCCTGAGGGAGACCTTGGCAAGGAGATTGAGCAGAAGTACGACTGTGGAGAAGAGATCCTGATCACGGTGCTGTCTG
CCATGACAGAGGAGGCAGCTGTTGCAATCAAGGCCATGGCAAAATAACTGGCTCCCAGGGTGGCGGTGGTGGCAGCAGTGATCCTCTGAA
CCTGCAGAGGCCCCCTCCCCGAGCCTGGCCTGGCTCTGGCCCGGTCCTAAGCTGGACTCCTCCTACACAATTTATTTGACGTTTTATTTT
GGTTTTCCCCACCCCCTCAATCTGTCGGGGAGCCCCTGCCCTTCACCTAGCTCCCTTGGCCAGGAGCGAGCGAAGCTGTGGCCTTGGTGA
AGCTGCCCTCCTCTTCTCCCCTCACACTACAGCCCTGGTGGGGGAGAAGGGGGTGGGTGCTGCTTGTGGTTTAGTCTTTTTTTTTTTTTT
TTTTTTAATTCAATCTGGAATCAGAAAGCGGTGGATTCTGGCAAATGGTCCTTGTGCCCTCCCCACTCATCCCTGGTCTGGTCCCCTGTT
GCCTATAGCCCTTTACCCTGAGCACCACCCCAACAGACTGGGGACCAGCCCCCTCGCCTGCCTGTGTCTCTCCCCAAACCCCTTTAGATG
GGGAGGGAAGAGGAGGAGAGGGGAGGGGACCTGCCCCCTCCTCAGGCATCTGGGAGGGCCCTGCCCCCATGGGCTTTACCCTTCCCTGCG

>93149_93149_4_TOX2-EIF5A_TOX2_chr20_42635432_ENST00000423191_EIF5A_chr17_7212934_ENST00000336452_length(amino acids)=256AA_BP=95
MSDGNPELLSTSQTYNGQSENNEDYEIPPITPPNLPEPSLLHLGDHEASYHSLCHGLTPNGLLPAYSYQAMDLPAIMVSNMLAQDSHLLS
GQLPTLESKPLKMADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TOX2-EIF5A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for TOX2-EIF5A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TOX2-EIF5A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene		C0007097	Carcinoma	1	CTD_human
Tgene		C0022548	Keloid	1	CTD_human
Tgene		C0024667	Animal Mammary Neoplasms	1	CTD_human
Tgene		C0024668	Mammary Neoplasms, Experimental	1	CTD_human
Tgene		C0205696	Anaplastic carcinoma	1	CTD_human
Tgene		C0205697	Carcinoma, Spindle-Cell	1	CTD_human
Tgene		C0205698	Undifferentiated carcinoma	1	CTD_human
Tgene		C0205699	Carcinomatosis	1	CTD_human
Tgene		C1257925	Mammary Carcinoma, Animal	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:TOX2-EIF5A (FusionGDB2 ID:HG84969TG1984)

Fusion Gene Summary for TOX2-EIF5A

Fusion Gene ORF analysis for TOX2-EIF5A

Fusion Genomic Features for TOX2-EIF5A

Fusion Protein Features for TOX2-EIF5A

Fusion Gene Sequence for TOX2-EIF5A

Fusion Gene PPI Analysis for TOX2-EIF5A

Related Drugs for TOX2-EIF5A

Related Diseases for TOX2-EIF5A

Fusion Gene Studies
in Kim Lab