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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:AGPS-LMNA (FusionGDB2 ID:HG8540TG4000)

Fusion Gene Summary for AGPS-LMNA

Fusion gene summary

Fusion gene information	Fusion gene name: AGPS-LMNA
	Fusion gene ID: hg8540tg4000
		Hgene	Tgene
	Gene symbol	AGPS	LMNA
	Gene ID	8540	4000
	Gene name	alkylglycerone phosphate synthase	lamin A/C
	Synonyms	ADAP-S\|ADAS\|ADHAPS\|ADPS\|ALDHPSY\|RCDP3	CDCD1\|CDDC\|CMD1A\|CMT2B1\|EMD2\|FPL\|FPLD\|FPLD2\|HGPS\|IDC\|LDP1\|LFP\|LGMD1B\|LMN1\|LMNC\|LMNL1\|MADA\|PRO1
	Cytomap	('AGPS')('LMNA') 2q31.2	1q22
	Type of gene	protein-coding	protein-coding
	Description	alkyldihydroxyacetonephosphate synthase, peroxisomalaging-associated gene 5 proteinaging-associated protein 5alkyl-DHAP synthase	lamin70 kDa laminepididymis secretory sperm binding proteinlamin A/C-like 1mandibuloacral dysplasia type Aprelamin-A/Crenal carcinoma antigen NY-REN-32
	Modification date	20200313	20200329
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000264167, ENST00000409888,
Fusion gene scores	* DoF score	8 X 8 X 7=448	13 X 16 X 6=1248
	# samples	10	16
	** MAII score	log2(10/448*10)=-2.16349873228288 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/1248*10)=-2.96347412397489 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: AGPS [Title/Abstract] AND LMNA [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	AGPS(178310354)-LMNA(156104595), # samples:1
Anticipated loss of major functional domain due to fusion event.	AGPS-LMNA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AGPS-LMNA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AGPS-LMNA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. AGPS-LMNA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	AGPS	GO:0008610	lipid biosynthetic process	9553082
Tgene	LMNA	GO:0090343	positive regulation of cell aging	20458013

Fusion gene breakpoints across AGPS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LMNA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	KIRC	TCGA-B0-5399	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+

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Fusion Gene ORF analysis for AGPS-LMNA

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000264167	ENST00000496738	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+
In-frame	ENST00000264167	ENST00000347559	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+
In-frame	ENST00000264167	ENST00000361308	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+
In-frame	ENST00000264167	ENST00000368297	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+
In-frame	ENST00000264167	ENST00000368299	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+
In-frame	ENST00000264167	ENST00000368300	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+
In-frame	ENST00000264167	ENST00000368301	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+
In-frame	ENST00000264167	ENST00000392353	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+
In-frame	ENST00000264167	ENST00000448611	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+
In-frame	ENST00000264167	ENST00000473598	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+
intron-3CDS	ENST00000409888	ENST00000347559	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+
intron-3CDS	ENST00000409888	ENST00000361308	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+
intron-3CDS	ENST00000409888	ENST00000368297	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+
intron-3CDS	ENST00000409888	ENST00000368299	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+
intron-3CDS	ENST00000409888	ENST00000368300	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+
intron-3CDS	ENST00000409888	ENST00000368301	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+
intron-3CDS	ENST00000409888	ENST00000392353	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+
intron-3CDS	ENST00000409888	ENST00000448611	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+
intron-3CDS	ENST00000409888	ENST00000473598	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+
intron-intron	ENST00000409888	ENST00000496738	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000264167	AGPS	chr2	178310354	+	ENST00000368301	LMNA	chr1	156104595	+	2197	1016	68	2095	675
ENST00000264167	AGPS	chr2	178310354	+	ENST00000361308	LMNA	chr1	156104595	+	2197	1016	68	2095	675
ENST00000264167	AGPS	chr2	178310354	+	ENST00000347559	LMNA	chr1	156104595	+	3263	1016	68	2281	737
ENST00000264167	AGPS	chr2	178310354	+	ENST00000368300	LMNA	chr1	156104595	+	3355	1016	68	2371	767
ENST00000264167	AGPS	chr2	178310354	+	ENST00000368299	LMNA	chr1	156104595	+	2433	1016	68	2221	717
ENST00000264167	AGPS	chr2	178310354	+	ENST00000448611	LMNA	chr1	156104595	+	2612	1016	68	2437	789
ENST00000264167	AGPS	chr2	178310354	+	ENST00000368297	LMNA	chr1	156104595	+	2197	1016	68	2095	675
ENST00000264167	AGPS	chr2	178310354	+	ENST00000473598	LMNA	chr1	156104595	+	2569	1016	68	2371	767
ENST00000264167	AGPS	chr2	178310354	+	ENST00000392353	LMNA	chr1	156104595	+	2197	1016	68	2095	675

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000264167	ENST00000368301	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+	0.014424324	0.9855757
ENST00000264167	ENST00000361308	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+	0.014424324	0.9855757
ENST00000264167	ENST00000347559	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+	0.00935209	0.99064785
ENST00000264167	ENST00000368300	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+	0.007298089	0.9927019
ENST00000264167	ENST00000368299	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+	0.015775016	0.98422503
ENST00000264167	ENST00000448611	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+	0.010469984	0.98953
ENST00000264167	ENST00000368297	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+	0.014424324	0.9855757
ENST00000264167	ENST00000473598	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+	0.014060487	0.9859395
ENST00000264167	ENST00000392353	AGPS	chr2	178310354	+	LMNA	chr1	156104595	+	0.014424324	0.9855757

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Fusion Genomic Features for AGPS-LMNA

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
AGPS	chr2	178310354	+	LMNA	chr1	156104595	+	6.50E-10	1
AGPS	chr2	178310354	+	LMNA	chr1	156104595	+	6.50E-10	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AGPS-LMNA

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:178310354/chr1:156104595)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AGPS

chr2:178310354

chr1:156104595

ENST00000264167

2_8

290

659.0

Compositional bias

Note=Poly-Ala

Hgene

AGPS

chr2:178310354

chr1:156104595

ENST00000264167

234_240

290

659.0

Nucleotide binding

FAD

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000347559

428_545

213

635.0

Domain

LTD

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000361308

428_545

213

573.0

Domain

LTD

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000368300

428_545

213

665.0

Domain

LTD

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000368301

428_545

213

573.0

Domain

LTD

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000448611

428_545

101

575.0

Domain

LTD

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000347559

417_422

213

635.0

Motif

Nuclear localization signal

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000361308

417_422

213

573.0

Motif

Nuclear localization signal

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000368300

417_422

213

665.0

Motif

Nuclear localization signal

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000368301

417_422

213

573.0

Motif

Nuclear localization signal

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000448611

417_422

101

575.0

Motif

Nuclear localization signal

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000347559

219_242

213

635.0

Region

Note=Linker 2

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000347559

243_383

213

635.0

Region

Note=Coil 2

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000347559

384_664

213

635.0

Region

Note=Tail

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000361308

219_242

213

573.0

Region

Note=Linker 2

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000361308

243_383

213

573.0

Region

Note=Coil 2

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000361308

384_664

213

573.0

Region

Note=Tail

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000368300

219_242

213

665.0

Region

Note=Linker 2

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000368300

243_383

213

665.0

Region

Note=Coil 2

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000368300

384_664

213

665.0

Region

Note=Tail

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000368301

219_242

213

573.0

Region

Note=Linker 2

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000368301

243_383

213

573.0

Region

Note=Coil 2

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000368301

384_664

213

573.0

Region

Note=Tail

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000448611

219_242

101

575.0

Region

Note=Linker 2

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000448611

243_383

101

575.0

Region

Note=Coil 2

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000448611

384_664

101

575.0

Region

Note=Tail

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AGPS

chr2:178310354

chr1:156104595

ENST00000264167

202_384

290

659.0

Domain

FAD-binding PCMH-type

Hgene

AGPS

chr2:178310354

chr1:156104595

ENST00000264167

303_309

290

659.0

Nucleotide binding

FAD

Hgene

AGPS

chr2:178310354

chr1:156104595

ENST00000264167

316_319

290

659.0

Nucleotide binding

FAD

Hgene

AGPS

chr2:178310354

chr1:156104595

ENST00000264167

368_374

290

659.0

Nucleotide binding

FAD

Hgene

AGPS

chr2:178310354

chr1:156104595

ENST00000264167

615_617

290

659.0

Region

Important for enzyme activity

Hgene

AGPS

chr2:178310354

chr1:156104595

ENST00000264167

654_658

290

659.0

Region

Important for enzyme activity

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000347559

31_387

213

635.0

Domain

IF rod

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000361308

31_387

213

573.0

Domain

IF rod

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000368300

31_387

213

665.0

Domain

IF rod

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000368301

31_387

213

573.0

Domain

IF rod

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000448611

31_387

101

575.0

Domain

IF rod

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000347559

1_33

213

635.0

Region

Note=Head

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000347559

34_70

213

635.0

Region

Note=Coil 1A

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000347559

71_80

213

635.0

Region

Note=Linker 1

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000347559

81_218

213

635.0

Region

Note=Coil 1B

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000361308

1_33

213

573.0

Region

Note=Head

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000361308

34_70

213

573.0

Region

Note=Coil 1A

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000361308

71_80

213

573.0

Region

Note=Linker 1

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000361308

81_218

213

573.0

Region

Note=Coil 1B

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000368300

1_33

213

665.0

Region

Note=Head

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000368300

34_70

213

665.0

Region

Note=Coil 1A

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000368300

71_80

213

665.0

Region

Note=Linker 1

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000368300

81_218

213

665.0

Region

Note=Coil 1B

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000368301

1_33

213

573.0

Region

Note=Head

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000368301

34_70

213

573.0

Region

Note=Coil 1A

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000368301

71_80

213

573.0

Region

Note=Linker 1

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000368301

81_218

213

573.0

Region

Note=Coil 1B

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000448611

1_33

101

575.0

Region

Note=Head

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000448611

34_70

101

575.0

Region

Note=Coil 1A

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000448611

71_80

101

575.0

Region

Note=Linker 1

Tgene

LMNA

chr2:178310354

chr1:156104595

ENST00000448611

81_218

101

575.0

Region

Note=Coil 1B

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Fusion Gene Sequence for AGPS-LMNA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>2980_2980_1_AGPS-LMNA_AGPS_chr2_178310354_ENST00000264167_LMNA_chr1_156104595_ENST00000347559_length(transcript)=3263nt_BP=1016nt
GTGAAGCTCCAGACGCATGGCACCCGCCGCCAAGTCGCCGCGGTGGCTGCCGGGATGCGCCGCAGCGAATGGTCGCGCCGGGCGCCGCTC
TGAGTGACCTTTCACCCGCGCCCAGCGGTTCCGGGCGGCAGCACAAGGCGGTAGCCATGGCGGAGGCGGCGGCTGCAGCGGGTGGGACTG
GCTTGGGCGCGGGCGCGAGCTACGGGTCTGCAGCGGACCGGGACCGGGACCCGGACCCGGACCGCGCCGGGCGGAGGCTGCGGGTTCTCT
CTGGCCATCTGCTGGGCCGGCCCCGGGAGGCTCTGAGTACCAATGAGTGCAAAGCGCGGAGAGCCGCGTCGGCGGCCACGGCAGCGCCCA
CGGCCACTCCCGCCGCGCAGGAGTCGGGCACCATCCCAAAGAAGCGGCAAGAAGTTATGAAATGGAATGGATGGGGATATAATGATTCTA
AATTCATCTTCAATAAGAAGGGCCAAATTGAATTGACTGGGAAAAGGTACCCTCTTAGTGGCATGGGTTTACCAACATTTAAAGAATGGA
TCCAAAATACCCTTGGAGTAAATGTGGAGCATAAAACTACCTCTAAAGCATCCTTAAATCCTAGTGATACACCTCCTTCTGTTGTAAATG
AAGATTTTCTTCATGACCTTAAAGAAACTAATATTTCATATTCACAAGAGGCAGATGATCGAGTATTTAGAGCTCATGGTCATTGTCTTC
ATGAGATATTTTTGCTCAGGGAAGGAATGTTTGAGCGAATTCCTGATATAGTTTTATGGCCAACATGCCATGATGATGTAGTTAAGATTG
TGAATCTAGCTTGCAAATATAATCTTTGTATCATACCAATTGGTGGAGGAACAAGTGTTTCATATGGCCTGATGTGTCCTGCAGATGAGA
CAAGAACAATTATTTCTTTGGACACTTCACAAATGAATCGAATTCTCTGGGTTGATGAGAACAATTTGACAGCTCATGTAGAGGCTGGCA
TAACAGGACAAGAGTTGGAAAGACAGGAGCTGCGTGAGACCAAGCGCCGTCATGAGACCCGACTGGTGGAGATTGACAATGGGAAGCAGC
GTGAGTTTGAGAGCCGGCTGGCGGATGCGCTGCAGGAACTGCGGGCCCAGCATGAGGACCAGGTGGAGCAGTATAAGAAGGAGCTGGAGA
AGACTTATTCTGCCAAGCTGGACAATGCCAGGCAGTCTGCTGAGAGGAACAGCAACCTGGTGGGGGCTGCCCACGAGGAGCTGCAGCAGT
CGCGCATCCGCATCGACAGCCTCTCTGCCCAGCTCAGCCAGCTCCAGAAGCAGCTGGCAGCCAAGGAGGCGAAGCTTCGAGACCTGGAGG
ACTCACTGGCCCGTGAGCGGGACACCAGCCGGCGGCTGCTGGCGGAAAAGGAGCGGGAGATGGCCGAGATGCGGGCAAGGATGCAGCAGC
AGCTGGACGAGTACCAGGAGCTTCTGGACATCAAGCTGGCCCTGGACATGGAGATCCACGCCTACCGCAAGCTCTTGGAGGGCGAGGAGG
AGAGGCTACGCCTGTCCCCCAGCCCTACCTCGCAGCGCAGCCGTGGCCGTGCTTCCTCTCACTCATCCCAGACACAGGGTGGGGGCAGCG
TCACCAAAAAGCGCAAACTGGAGTCCACTGAGAGCCGCAGCAGCTTCTCACAGCACGCACGCACTAGCGGGCGCGTGGCCGTGGAGGAGG
TGGATGAGGAGGGCAAGTTTGTCCGGCTGCGCAACAAGTCCAATGAGGACCAGTCCATGGGCAATTGGCAGATCAAGCGCCAGAATGGAG
ATGATCCCTTGCTGACTTACCGGTTCCCACCAAAGTTCACCCTGAAGGCTGGGCAGGTGGTGACGATCTGGGCTGCAGGAGCTGGGGCCA
CCCACAGCCCCCCTACCGACCTGGTGTGGAAGGCACAGAACACCTGGGGCTGCGGGAACAGCCTGCGTACGGCTCTCATCAACTCCACTG
GGGAAGGCTCCCACTGCAGCAGCTCGGGGGACCCCGCTGAGTACAACCTGCGCTCGCGCACCGTGCTGTGCGGGACCTGCGGGCAGCCTG
CCGACAAGGCATCTGCCAGCGGCTCAGGAGCCCAGGTGGGCGGACCCATCTCCTCTGGCTCTTCTGCCTCCAGTGTCACGGTCACTCGCA
GCTACCGCAGTGTGGGGGGCAGTGGGGGTGGCAGCTTCGGGGACAATCTGGTCACCCGCTCCTACCTCCTGGGCAACTCCAGCCCCCGAA
CCCAGAGCCCCCAGAACTGCAGCATCATGTAATCTGGGACCTGCCAGGCAGGGGTGGGGGTGGAGGCTTCCTGCGTCCTCCTCACCTCAT
GCCCACCCCCTGCCCTGCACGTCATGGGAGGGGGCTTGAAGCCAAAGAAAAATAACCCTTTGGTTTTTTTCTTCTGTATTTTTTTTTCTA
AGAGAAGTTATTTTCTACAGTGGTTTTATACTGAAGGAAAAACACAAGCAAAAAAAAAAAAAAGCATCTATCTCATCTATCTCAATCCTA
ATTTCTCCTCCCTTCCTTTTCCCTGCTTCCAGGAAACTCCACATCTGCCTTAAAACCAAAGAGGGCTTCCTCTAGAAGCCAAGGGAAAGG
GGTGCTTTTATAGAGGCTAGCTTCTGCTTTTCTGCCCTGGCTGCTGCCCCCACCCCGGGGACCCTGTGACATGGTGCCTGAGAGGCAGGC
ATAGAGGCTTCTCCGCCAGCCTCCTCTGGACGGCAGGCTCACTGCCAGGCCAGCCTCCGAGAGGGAGAGAGAGAGAGAGAGGACAGCTTG
AGCCGGGCCCCTGGGCTTGGCCTGCTGTGATTCCACTACACCTGGCTGAGGTTCCTCTGCCTGCCCCGCCCCCAGTCCCCACCCCTGCCC
CCAGCCCCGGGGTGAGTCCATTCTCCCAGGTACCAGCTGCGCTTGCTTTTCTGTATTTTATTTAGACAAGAGATGGGAATGAGGTGGGAG
GTGGAAGAAGGGAGAAGAAAGGTGAGTTTGAGCTGCCTTCCCTAGCTTTAGACCCTGGGTGGGCTCTGTGCAGTCACTGGAGGTTGAAGC
CAAGTGGGGTGCTGGGAGGAGGGAGAGGGAGGTCACTGGAAAGGGGAGAGCCTGCTGGCACCCACCGTGGAGGAGGAAGGCAAGAGGGGG
TGGAGGGGTGTGGCAGTGGTTTTGGCAAACGCTAAAGAGCCCTTGCCTCCCCATTTCCCATCTGCACCCCTTCTCTCCTCCCCAAATCAA

>2980_2980_1_AGPS-LMNA_AGPS_chr2_178310354_ENST00000264167_LMNA_chr1_156104595_ENST00000347559_length(amino acids)=737AA_BP=315
MVAPGAALSDLSPAPSGSGRQHKAVAMAEAAAAAGGTGLGAGASYGSAADRDRDPDPDRAGRRLRVLSGHLLGRPREALSTNECKARRAA
SAATAAPTATPAAQESGTIPKKRQEVMKWNGWGYNDSKFIFNKKGQIELTGKRYPLSGMGLPTFKEWIQNTLGVNVEHKTTSKASLNPSD
TPPSVVNEDFLHDLKETNISYSQEADDRVFRAHGHCLHEIFLLREGMFERIPDIVLWPTCHDDVVKIVNLACKYNLCIIPIGGGTSVSYG
LMCPADETRTIISLDTSQMNRILWVDENNLTAHVEAGITGQELERQELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVE
QYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAE
MRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTS
GRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLR
TALINSTGEGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASASGSGAQVGGPISSGSSASSVTVTRSYRSVGGSGGGSFGDNLVTRSYL

--------------------------------------------------------------
>2980_2980_2_AGPS-LMNA_AGPS_chr2_178310354_ENST00000264167_LMNA_chr1_156104595_ENST00000361308_length(transcript)=2197nt_BP=1016nt
GTGAAGCTCCAGACGCATGGCACCCGCCGCCAAGTCGCCGCGGTGGCTGCCGGGATGCGCCGCAGCGAATGGTCGCGCCGGGCGCCGCTC
TGAGTGACCTTTCACCCGCGCCCAGCGGTTCCGGGCGGCAGCACAAGGCGGTAGCCATGGCGGAGGCGGCGGCTGCAGCGGGTGGGACTG
GCTTGGGCGCGGGCGCGAGCTACGGGTCTGCAGCGGACCGGGACCGGGACCCGGACCCGGACCGCGCCGGGCGGAGGCTGCGGGTTCTCT
CTGGCCATCTGCTGGGCCGGCCCCGGGAGGCTCTGAGTACCAATGAGTGCAAAGCGCGGAGAGCCGCGTCGGCGGCCACGGCAGCGCCCA
CGGCCACTCCCGCCGCGCAGGAGTCGGGCACCATCCCAAAGAAGCGGCAAGAAGTTATGAAATGGAATGGATGGGGATATAATGATTCTA
AATTCATCTTCAATAAGAAGGGCCAAATTGAATTGACTGGGAAAAGGTACCCTCTTAGTGGCATGGGTTTACCAACATTTAAAGAATGGA
TCCAAAATACCCTTGGAGTAAATGTGGAGCATAAAACTACCTCTAAAGCATCCTTAAATCCTAGTGATACACCTCCTTCTGTTGTAAATG
AAGATTTTCTTCATGACCTTAAAGAAACTAATATTTCATATTCACAAGAGGCAGATGATCGAGTATTTAGAGCTCATGGTCATTGTCTTC
ATGAGATATTTTTGCTCAGGGAAGGAATGTTTGAGCGAATTCCTGATATAGTTTTATGGCCAACATGCCATGATGATGTAGTTAAGATTG
TGAATCTAGCTTGCAAATATAATCTTTGTATCATACCAATTGGTGGAGGAACAAGTGTTTCATATGGCCTGATGTGTCCTGCAGATGAGA
CAAGAACAATTATTTCTTTGGACACTTCACAAATGAATCGAATTCTCTGGGTTGATGAGAACAATTTGACAGCTCATGTAGAGGCTGGCA
TAACAGGACAAGAGTTGGAAAGACAGGAGCTGCGTGAGACCAAGCGCCGTCATGAGACCCGACTGGTGGAGATTGACAATGGGAAGCAGC
GTGAGTTTGAGAGCCGGCTGGCGGATGCGCTGCAGGAACTGCGGGCCCAGCATGAGGACCAGGTGGAGCAGTATAAGAAGGAGCTGGAGA
AGACTTATTCTGCCAAGCTGGACAATGCCAGGCAGTCTGCTGAGAGGAACAGCAACCTGGTGGGGGCTGCCCACGAGGAGCTGCAGCAGT
CGCGCATCCGCATCGACAGCCTCTCTGCCCAGCTCAGCCAGCTCCAGAAGCAGCTGGCAGCCAAGGAGGCGAAGCTTCGAGACCTGGAGG
ACTCACTGGCCCGTGAGCGGGACACCAGCCGGCGGCTGCTGGCGGAAAAGGAGCGGGAGATGGCCGAGATGCGGGCAAGGATGCAGCAGC
AGCTGGACGAGTACCAGGAGCTTCTGGACATCAAGCTGGCCCTGGACATGGAGATCCACGCCTACCGCAAGCTCTTGGAGGGCGAGGAGG
AGAGGCTACGCCTGTCCCCCAGCCCTACCTCGCAGCGCAGCCGTGGCCGTGCTTCCTCTCACTCATCCCAGACACAGGGTGGGGGCAGCG
TCACCAAAAAGCGCAAACTGGAGTCCACTGAGAGCCGCAGCAGCTTCTCACAGCACGCACGCACTAGCGGGCGCGTGGCCGTGGAGGAGG
TGGATGAGGAGGGCAAGTTTGTCCGGCTGCGCAACAAGTCCAATGAGGACCAGTCCATGGGCAATTGGCAGATCAAGCGCCAGAATGGAG
ATGATCCCTTGCTGACTTACCGGTTCCCACCAAAGTTCACCCTGAAGGCTGGGCAGGTGGTGACGATCTGGGCTGCAGGAGCTGGGGCCA
CCCACAGCCCCCCTACCGACCTGGTGTGGAAGGCACAGAACACCTGGGGCTGCGGGAACAGCCTGCGTACGGCTCTCATCAACTCCACTG
GGGAAGAAGTGGCCATGCGCAAGCTGGTGCGCTCAGTGACTGTGGTTGAGGACGACGAGGATGAGGATGGAGATGACCTGCTCCATCACC
ACCACGTGAGTGGTAGCCGCCGCTGAGGCCGAGCCTGCACTGGGGCCACCCAGCCAGGCCTGGGGGCAGCCTCTCCCCAGCCTCCCCGTG

>2980_2980_2_AGPS-LMNA_AGPS_chr2_178310354_ENST00000264167_LMNA_chr1_156104595_ENST00000361308_length(amino acids)=675AA_BP=315
MVAPGAALSDLSPAPSGSGRQHKAVAMAEAAAAAGGTGLGAGASYGSAADRDRDPDPDRAGRRLRVLSGHLLGRPREALSTNECKARRAA
SAATAAPTATPAAQESGTIPKKRQEVMKWNGWGYNDSKFIFNKKGQIELTGKRYPLSGMGLPTFKEWIQNTLGVNVEHKTTSKASLNPSD
TPPSVVNEDFLHDLKETNISYSQEADDRVFRAHGHCLHEIFLLREGMFERIPDIVLWPTCHDDVVKIVNLACKYNLCIIPIGGGTSVSYG
LMCPADETRTIISLDTSQMNRILWVDENNLTAHVEAGITGQELERQELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVE
QYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAE
MRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTS
GRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLR

--------------------------------------------------------------
>2980_2980_3_AGPS-LMNA_AGPS_chr2_178310354_ENST00000264167_LMNA_chr1_156104595_ENST00000368297_length(transcript)=2197nt_BP=1016nt
GTGAAGCTCCAGACGCATGGCACCCGCCGCCAAGTCGCCGCGGTGGCTGCCGGGATGCGCCGCAGCGAATGGTCGCGCCGGGCGCCGCTC
TGAGTGACCTTTCACCCGCGCCCAGCGGTTCCGGGCGGCAGCACAAGGCGGTAGCCATGGCGGAGGCGGCGGCTGCAGCGGGTGGGACTG
GCTTGGGCGCGGGCGCGAGCTACGGGTCTGCAGCGGACCGGGACCGGGACCCGGACCCGGACCGCGCCGGGCGGAGGCTGCGGGTTCTCT
CTGGCCATCTGCTGGGCCGGCCCCGGGAGGCTCTGAGTACCAATGAGTGCAAAGCGCGGAGAGCCGCGTCGGCGGCCACGGCAGCGCCCA
CGGCCACTCCCGCCGCGCAGGAGTCGGGCACCATCCCAAAGAAGCGGCAAGAAGTTATGAAATGGAATGGATGGGGATATAATGATTCTA
AATTCATCTTCAATAAGAAGGGCCAAATTGAATTGACTGGGAAAAGGTACCCTCTTAGTGGCATGGGTTTACCAACATTTAAAGAATGGA
TCCAAAATACCCTTGGAGTAAATGTGGAGCATAAAACTACCTCTAAAGCATCCTTAAATCCTAGTGATACACCTCCTTCTGTTGTAAATG
AAGATTTTCTTCATGACCTTAAAGAAACTAATATTTCATATTCACAAGAGGCAGATGATCGAGTATTTAGAGCTCATGGTCATTGTCTTC
ATGAGATATTTTTGCTCAGGGAAGGAATGTTTGAGCGAATTCCTGATATAGTTTTATGGCCAACATGCCATGATGATGTAGTTAAGATTG
TGAATCTAGCTTGCAAATATAATCTTTGTATCATACCAATTGGTGGAGGAACAAGTGTTTCATATGGCCTGATGTGTCCTGCAGATGAGA
CAAGAACAATTATTTCTTTGGACACTTCACAAATGAATCGAATTCTCTGGGTTGATGAGAACAATTTGACAGCTCATGTAGAGGCTGGCA
TAACAGGACAAGAGTTGGAAAGACAGGAGCTGCGTGAGACCAAGCGCCGTCATGAGACCCGACTGGTGGAGATTGACAATGGGAAGCAGC
GTGAGTTTGAGAGCCGGCTGGCGGATGCGCTGCAGGAACTGCGGGCCCAGCATGAGGACCAGGTGGAGCAGTATAAGAAGGAGCTGGAGA
AGACTTATTCTGCCAAGCTGGACAATGCCAGGCAGTCTGCTGAGAGGAACAGCAACCTGGTGGGGGCTGCCCACGAGGAGCTGCAGCAGT
CGCGCATCCGCATCGACAGCCTCTCTGCCCAGCTCAGCCAGCTCCAGAAGCAGCTGGCAGCCAAGGAGGCGAAGCTTCGAGACCTGGAGG
ACTCACTGGCCCGTGAGCGGGACACCAGCCGGCGGCTGCTGGCGGAAAAGGAGCGGGAGATGGCCGAGATGCGGGCAAGGATGCAGCAGC
AGCTGGACGAGTACCAGGAGCTTCTGGACATCAAGCTGGCCCTGGACATGGAGATCCACGCCTACCGCAAGCTCTTGGAGGGCGAGGAGG
AGAGGCTACGCCTGTCCCCCAGCCCTACCTCGCAGCGCAGCCGTGGCCGTGCTTCCTCTCACTCATCCCAGACACAGGGTGGGGGCAGCG
TCACCAAAAAGCGCAAACTGGAGTCCACTGAGAGCCGCAGCAGCTTCTCACAGCACGCACGCACTAGCGGGCGCGTGGCCGTGGAGGAGG
TGGATGAGGAGGGCAAGTTTGTCCGGCTGCGCAACAAGTCCAATGAGGACCAGTCCATGGGCAATTGGCAGATCAAGCGCCAGAATGGAG
ATGATCCCTTGCTGACTTACCGGTTCCCACCAAAGTTCACCCTGAAGGCTGGGCAGGTGGTGACGATCTGGGCTGCAGGAGCTGGGGCCA
CCCACAGCCCCCCTACCGACCTGGTGTGGAAGGCACAGAACACCTGGGGCTGCGGGAACAGCCTGCGTACGGCTCTCATCAACTCCACTG
GGGAAGAAGTGGCCATGCGCAAGCTGGTGCGCTCAGTGACTGTGGTTGAGGACGACGAGGATGAGGATGGAGATGACCTGCTCCATCACC
ACCACGTGAGTGGTAGCCGCCGCTGAGGCCGAGCCTGCACTGGGGCCACCCAGCCAGGCCTGGGGGCAGCCTCTCCCCAGCCTCCCCGTG

>2980_2980_3_AGPS-LMNA_AGPS_chr2_178310354_ENST00000264167_LMNA_chr1_156104595_ENST00000368297_length(amino acids)=675AA_BP=315
MVAPGAALSDLSPAPSGSGRQHKAVAMAEAAAAAGGTGLGAGASYGSAADRDRDPDPDRAGRRLRVLSGHLLGRPREALSTNECKARRAA
SAATAAPTATPAAQESGTIPKKRQEVMKWNGWGYNDSKFIFNKKGQIELTGKRYPLSGMGLPTFKEWIQNTLGVNVEHKTTSKASLNPSD
TPPSVVNEDFLHDLKETNISYSQEADDRVFRAHGHCLHEIFLLREGMFERIPDIVLWPTCHDDVVKIVNLACKYNLCIIPIGGGTSVSYG
LMCPADETRTIISLDTSQMNRILWVDENNLTAHVEAGITGQELERQELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVE
QYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAE
MRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTS
GRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLR

--------------------------------------------------------------
>2980_2980_4_AGPS-LMNA_AGPS_chr2_178310354_ENST00000264167_LMNA_chr1_156104595_ENST00000368299_length(transcript)=2433nt_BP=1016nt
GTGAAGCTCCAGACGCATGGCACCCGCCGCCAAGTCGCCGCGGTGGCTGCCGGGATGCGCCGCAGCGAATGGTCGCGCCGGGCGCCGCTC
TGAGTGACCTTTCACCCGCGCCCAGCGGTTCCGGGCGGCAGCACAAGGCGGTAGCCATGGCGGAGGCGGCGGCTGCAGCGGGTGGGACTG
GCTTGGGCGCGGGCGCGAGCTACGGGTCTGCAGCGGACCGGGACCGGGACCCGGACCCGGACCGCGCCGGGCGGAGGCTGCGGGTTCTCT
CTGGCCATCTGCTGGGCCGGCCCCGGGAGGCTCTGAGTACCAATGAGTGCAAAGCGCGGAGAGCCGCGTCGGCGGCCACGGCAGCGCCCA
CGGCCACTCCCGCCGCGCAGGAGTCGGGCACCATCCCAAAGAAGCGGCAAGAAGTTATGAAATGGAATGGATGGGGATATAATGATTCTA
AATTCATCTTCAATAAGAAGGGCCAAATTGAATTGACTGGGAAAAGGTACCCTCTTAGTGGCATGGGTTTACCAACATTTAAAGAATGGA
TCCAAAATACCCTTGGAGTAAATGTGGAGCATAAAACTACCTCTAAAGCATCCTTAAATCCTAGTGATACACCTCCTTCTGTTGTAAATG
AAGATTTTCTTCATGACCTTAAAGAAACTAATATTTCATATTCACAAGAGGCAGATGATCGAGTATTTAGAGCTCATGGTCATTGTCTTC
ATGAGATATTTTTGCTCAGGGAAGGAATGTTTGAGCGAATTCCTGATATAGTTTTATGGCCAACATGCCATGATGATGTAGTTAAGATTG
TGAATCTAGCTTGCAAATATAATCTTTGTATCATACCAATTGGTGGAGGAACAAGTGTTTCATATGGCCTGATGTGTCCTGCAGATGAGA
CAAGAACAATTATTTCTTTGGACACTTCACAAATGAATCGAATTCTCTGGGTTGATGAGAACAATTTGACAGCTCATGTAGAGGCTGGCA
TAACAGGACAAGAGTTGGAAAGACAGGAGCTGCGTGAGACCAAGCGCCGTCATGAGACCCGACTGGTGGAGATTGACAATGGGAAGCAGC
GTGAGTTTGAGAGCCGGCTGGCGGATGCGCTGCAGGAACTGCGGGCCCAGCATGAGGACCAGGTGGAGCAGTATAAGAAGGAGCTGGAGA
AGACTTATTCTGCCAAGCTGGACAATGCCAGGCAGTCTGCTGAGAGGAACAGCAACCTGGTGGGGGCTGCCCACGAGGAGCTGCAGCAGT
CGCGCATCCGCATCGACAGCCTCTCTGCCCAGCTCAGCCAGCTCCAGAAGCAGCTGGCAGCCAAGGAGGCGAAGCTTCGAGACCTGGAGG
ACTCACTGGCCCGTGAGCGGGACACCAGCCGGCGGCTGCTGGCGGAAAAGGAGCGGGAGATGGCCGAGATGCGGGCAAGGATGCAGCAGC
AGCTGGACGAGTACCAGGAGCTTCTGGACATCAAGCTGGCCCTGGACATGGAGATCCACGCCTACCGCAAGCTCTTGGAGGGCGAGGAGG
AGAGGCTACGCCTGTCCCCCAGCCCTACCTCGCAGCGCAGCCGTGGCCGTGCTTCCTCTCACTCATCCCAGACACAGGGTGGGGGCAGCG
TCACCAAAAAGCGCAAACTGGAGTCCACTGAGAGCCGCAGCAGCTTCTCACAGCACGCACGCACTAGCGGGCGCGTGGCCGTGGAGGAGG
TGGATGAGGAGGGCAAGTTTGTCCGGCTGCGCAACAAGTCCAATGAGGACCAGTCCATGGGCAATTGGCAGATCAAGCGCCAGAATGGAG
ATGATCCCTTGCTGACTTACCGGTTCCCACCAAAGTTCACCCTGAAGGCTGGGCAGGTGGTGACGATCTGGGCTGCAGGAGCTGGGGCCA
CCCACAGCCCCCCTACCGACCTGGTGTGGAAGGCACAGAACACCTGGGGCTGCGGGAACAGCCTGCGTACGGCTCTCATCAACTCCACTG
GGGAAGAAGTGGCCATGCGCAAGCTGGTGCGCTCAGTGACTGTGGTTGAGGACGACGAGGATGAGGATGGAGATGACCTGCTCCATCACC
ACCACGGCTCCCACTGCAGCAGCTCGGGGGACCCCGCTGAGTACAACCTGCGCTCGCGCACCGTGCTGTGCGGGACCTGCGGGCAGCCTG
CCGACAAGGCATCTGCCAGCGGCTCAGGAGCCCAGAGCCCCCAGAACTGCAGCATCATGTAATCTGGGACCTGCCAGGCAGGGGTGGGGG
TGGAGGCTTCCTGCGTCCTCCTCACCTCATGCCCACCCCCTGCCCTGCACGTCATGGGAGGGGGCTTGAAGCCAAAGAAAAATAACCCTT
TGGTTTTTTTCTTCTGTATTTTTTTTTCTAAGAGAAGTTATTTTCTACAGTGGTTTTATACTGAAGGAAAAACACAAGCAAAAAAAAAAA

>2980_2980_4_AGPS-LMNA_AGPS_chr2_178310354_ENST00000264167_LMNA_chr1_156104595_ENST00000368299_length(amino acids)=717AA_BP=315
MVAPGAALSDLSPAPSGSGRQHKAVAMAEAAAAAGGTGLGAGASYGSAADRDRDPDPDRAGRRLRVLSGHLLGRPREALSTNECKARRAA
SAATAAPTATPAAQESGTIPKKRQEVMKWNGWGYNDSKFIFNKKGQIELTGKRYPLSGMGLPTFKEWIQNTLGVNVEHKTTSKASLNPSD
TPPSVVNEDFLHDLKETNISYSQEADDRVFRAHGHCLHEIFLLREGMFERIPDIVLWPTCHDDVVKIVNLACKYNLCIIPIGGGTSVSYG
LMCPADETRTIISLDTSQMNRILWVDENNLTAHVEAGITGQELERQELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVE
QYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAE
MRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTS
GRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLR

--------------------------------------------------------------
>2980_2980_5_AGPS-LMNA_AGPS_chr2_178310354_ENST00000264167_LMNA_chr1_156104595_ENST00000368300_length(transcript)=3355nt_BP=1016nt
GTGAAGCTCCAGACGCATGGCACCCGCCGCCAAGTCGCCGCGGTGGCTGCCGGGATGCGCCGCAGCGAATGGTCGCGCCGGGCGCCGCTC
TGAGTGACCTTTCACCCGCGCCCAGCGGTTCCGGGCGGCAGCACAAGGCGGTAGCCATGGCGGAGGCGGCGGCTGCAGCGGGTGGGACTG
GCTTGGGCGCGGGCGCGAGCTACGGGTCTGCAGCGGACCGGGACCGGGACCCGGACCCGGACCGCGCCGGGCGGAGGCTGCGGGTTCTCT
CTGGCCATCTGCTGGGCCGGCCCCGGGAGGCTCTGAGTACCAATGAGTGCAAAGCGCGGAGAGCCGCGTCGGCGGCCACGGCAGCGCCCA
CGGCCACTCCCGCCGCGCAGGAGTCGGGCACCATCCCAAAGAAGCGGCAAGAAGTTATGAAATGGAATGGATGGGGATATAATGATTCTA
AATTCATCTTCAATAAGAAGGGCCAAATTGAATTGACTGGGAAAAGGTACCCTCTTAGTGGCATGGGTTTACCAACATTTAAAGAATGGA
TCCAAAATACCCTTGGAGTAAATGTGGAGCATAAAACTACCTCTAAAGCATCCTTAAATCCTAGTGATACACCTCCTTCTGTTGTAAATG
AAGATTTTCTTCATGACCTTAAAGAAACTAATATTTCATATTCACAAGAGGCAGATGATCGAGTATTTAGAGCTCATGGTCATTGTCTTC
ATGAGATATTTTTGCTCAGGGAAGGAATGTTTGAGCGAATTCCTGATATAGTTTTATGGCCAACATGCCATGATGATGTAGTTAAGATTG
TGAATCTAGCTTGCAAATATAATCTTTGTATCATACCAATTGGTGGAGGAACAAGTGTTTCATATGGCCTGATGTGTCCTGCAGATGAGA
CAAGAACAATTATTTCTTTGGACACTTCACAAATGAATCGAATTCTCTGGGTTGATGAGAACAATTTGACAGCTCATGTAGAGGCTGGCA
TAACAGGACAAGAGTTGGAAAGACAGGAGCTGCGTGAGACCAAGCGCCGTCATGAGACCCGACTGGTGGAGATTGACAATGGGAAGCAGC
GTGAGTTTGAGAGCCGGCTGGCGGATGCGCTGCAGGAACTGCGGGCCCAGCATGAGGACCAGGTGGAGCAGTATAAGAAGGAGCTGGAGA
AGACTTATTCTGCCAAGCTGGACAATGCCAGGCAGTCTGCTGAGAGGAACAGCAACCTGGTGGGGGCTGCCCACGAGGAGCTGCAGCAGT
CGCGCATCCGCATCGACAGCCTCTCTGCCCAGCTCAGCCAGCTCCAGAAGCAGCTGGCAGCCAAGGAGGCGAAGCTTCGAGACCTGGAGG
ACTCACTGGCCCGTGAGCGGGACACCAGCCGGCGGCTGCTGGCGGAAAAGGAGCGGGAGATGGCCGAGATGCGGGCAAGGATGCAGCAGC
AGCTGGACGAGTACCAGGAGCTTCTGGACATCAAGCTGGCCCTGGACATGGAGATCCACGCCTACCGCAAGCTCTTGGAGGGCGAGGAGG
AGAGGCTACGCCTGTCCCCCAGCCCTACCTCGCAGCGCAGCCGTGGCCGTGCTTCCTCTCACTCATCCCAGACACAGGGTGGGGGCAGCG
TCACCAAAAAGCGCAAACTGGAGTCCACTGAGAGCCGCAGCAGCTTCTCACAGCACGCACGCACTAGCGGGCGCGTGGCCGTGGAGGAGG
TGGATGAGGAGGGCAAGTTTGTCCGGCTGCGCAACAAGTCCAATGAGGACCAGTCCATGGGCAATTGGCAGATCAAGCGCCAGAATGGAG
ATGATCCCTTGCTGACTTACCGGTTCCCACCAAAGTTCACCCTGAAGGCTGGGCAGGTGGTGACGATCTGGGCTGCAGGAGCTGGGGCCA
CCCACAGCCCCCCTACCGACCTGGTGTGGAAGGCACAGAACACCTGGGGCTGCGGGAACAGCCTGCGTACGGCTCTCATCAACTCCACTG
GGGAAGAAGTGGCCATGCGCAAGCTGGTGCGCTCAGTGACTGTGGTTGAGGACGACGAGGATGAGGATGGAGATGACCTGCTCCATCACC
ACCACGGCTCCCACTGCAGCAGCTCGGGGGACCCCGCTGAGTACAACCTGCGCTCGCGCACCGTGCTGTGCGGGACCTGCGGGCAGCCTG
CCGACAAGGCATCTGCCAGCGGCTCAGGAGCCCAGGTGGGCGGACCCATCTCCTCTGGCTCTTCTGCCTCCAGTGTCACGGTCACTCGCA
GCTACCGCAGTGTGGGGGGCAGTGGGGGTGGCAGCTTCGGGGACAATCTGGTCACCCGCTCCTACCTCCTGGGCAACTCCAGCCCCCGAA
CCCAGAGCCCCCAGAACTGCAGCATCATGTAATCTGGGACCTGCCAGGCAGGGGTGGGGGTGGAGGCTTCCTGCGTCCTCCTCACCTCAT
GCCCACCCCCTGCCCTGCACGTCATGGGAGGGGGCTTGAAGCCAAAGAAAAATAACCCTTTGGTTTTTTTCTTCTGTATTTTTTTTTCTA
AGAGAAGTTATTTTCTACAGTGGTTTTATACTGAAGGAAAAACACAAGCAAAAAAAAAAAAAAGCATCTATCTCATCTATCTCAATCCTA
ATTTCTCCTCCCTTCCTTTTCCCTGCTTCCAGGAAACTCCACATCTGCCTTAAAACCAAAGAGGGCTTCCTCTAGAAGCCAAGGGAAAGG
GGTGCTTTTATAGAGGCTAGCTTCTGCTTTTCTGCCCTGGCTGCTGCCCCCACCCCGGGGACCCTGTGACATGGTGCCTGAGAGGCAGGC
ATAGAGGCTTCTCCGCCAGCCTCCTCTGGACGGCAGGCTCACTGCCAGGCCAGCCTCCGAGAGGGAGAGAGAGAGAGAGAGGACAGCTTG
AGCCGGGCCCCTGGGCTTGGCCTGCTGTGATTCCACTACACCTGGCTGAGGTTCCTCTGCCTGCCCCGCCCCCAGTCCCCACCCCTGCCC
CCAGCCCCGGGGTGAGTCCATTCTCCCAGGTACCAGCTGCGCTTGCTTTTCTGTATTTTATTTAGACAAGAGATGGGAATGAGGTGGGAG
GTGGAAGAAGGGAGAAGAAAGGTGAGTTTGAGCTGCCTTCCCTAGCTTTAGACCCTGGGTGGGCTCTGTGCAGTCACTGGAGGTTGAAGC
CAAGTGGGGTGCTGGGAGGAGGGAGAGGGAGGTCACTGGAAAGGGGAGAGCCTGCTGGCACCCACCGTGGAGGAGGAAGGCAAGAGGGGG
TGGAGGGGTGTGGCAGTGGTTTTGGCAAACGCTAAAGAGCCCTTGCCTCCCCATTTCCCATCTGCACCCCTTCTCTCCTCCCCAAATCAA

>2980_2980_5_AGPS-LMNA_AGPS_chr2_178310354_ENST00000264167_LMNA_chr1_156104595_ENST00000368300_length(amino acids)=767AA_BP=315
MVAPGAALSDLSPAPSGSGRQHKAVAMAEAAAAAGGTGLGAGASYGSAADRDRDPDPDRAGRRLRVLSGHLLGRPREALSTNECKARRAA
SAATAAPTATPAAQESGTIPKKRQEVMKWNGWGYNDSKFIFNKKGQIELTGKRYPLSGMGLPTFKEWIQNTLGVNVEHKTTSKASLNPSD
TPPSVVNEDFLHDLKETNISYSQEADDRVFRAHGHCLHEIFLLREGMFERIPDIVLWPTCHDDVVKIVNLACKYNLCIIPIGGGTSVSYG
LMCPADETRTIISLDTSQMNRILWVDENNLTAHVEAGITGQELERQELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVE
QYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAE
MRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTS
GRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLR
TALINSTGEEVAMRKLVRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASASGSGAQVGGPISSGSSA

--------------------------------------------------------------
>2980_2980_6_AGPS-LMNA_AGPS_chr2_178310354_ENST00000264167_LMNA_chr1_156104595_ENST00000368301_length(transcript)=2197nt_BP=1016nt
GTGAAGCTCCAGACGCATGGCACCCGCCGCCAAGTCGCCGCGGTGGCTGCCGGGATGCGCCGCAGCGAATGGTCGCGCCGGGCGCCGCTC
TGAGTGACCTTTCACCCGCGCCCAGCGGTTCCGGGCGGCAGCACAAGGCGGTAGCCATGGCGGAGGCGGCGGCTGCAGCGGGTGGGACTG
GCTTGGGCGCGGGCGCGAGCTACGGGTCTGCAGCGGACCGGGACCGGGACCCGGACCCGGACCGCGCCGGGCGGAGGCTGCGGGTTCTCT
CTGGCCATCTGCTGGGCCGGCCCCGGGAGGCTCTGAGTACCAATGAGTGCAAAGCGCGGAGAGCCGCGTCGGCGGCCACGGCAGCGCCCA
CGGCCACTCCCGCCGCGCAGGAGTCGGGCACCATCCCAAAGAAGCGGCAAGAAGTTATGAAATGGAATGGATGGGGATATAATGATTCTA
AATTCATCTTCAATAAGAAGGGCCAAATTGAATTGACTGGGAAAAGGTACCCTCTTAGTGGCATGGGTTTACCAACATTTAAAGAATGGA
TCCAAAATACCCTTGGAGTAAATGTGGAGCATAAAACTACCTCTAAAGCATCCTTAAATCCTAGTGATACACCTCCTTCTGTTGTAAATG
AAGATTTTCTTCATGACCTTAAAGAAACTAATATTTCATATTCACAAGAGGCAGATGATCGAGTATTTAGAGCTCATGGTCATTGTCTTC
ATGAGATATTTTTGCTCAGGGAAGGAATGTTTGAGCGAATTCCTGATATAGTTTTATGGCCAACATGCCATGATGATGTAGTTAAGATTG
TGAATCTAGCTTGCAAATATAATCTTTGTATCATACCAATTGGTGGAGGAACAAGTGTTTCATATGGCCTGATGTGTCCTGCAGATGAGA
CAAGAACAATTATTTCTTTGGACACTTCACAAATGAATCGAATTCTCTGGGTTGATGAGAACAATTTGACAGCTCATGTAGAGGCTGGCA
TAACAGGACAAGAGTTGGAAAGACAGGAGCTGCGTGAGACCAAGCGCCGTCATGAGACCCGACTGGTGGAGATTGACAATGGGAAGCAGC
GTGAGTTTGAGAGCCGGCTGGCGGATGCGCTGCAGGAACTGCGGGCCCAGCATGAGGACCAGGTGGAGCAGTATAAGAAGGAGCTGGAGA
AGACTTATTCTGCCAAGCTGGACAATGCCAGGCAGTCTGCTGAGAGGAACAGCAACCTGGTGGGGGCTGCCCACGAGGAGCTGCAGCAGT
CGCGCATCCGCATCGACAGCCTCTCTGCCCAGCTCAGCCAGCTCCAGAAGCAGCTGGCAGCCAAGGAGGCGAAGCTTCGAGACCTGGAGG
ACTCACTGGCCCGTGAGCGGGACACCAGCCGGCGGCTGCTGGCGGAAAAGGAGCGGGAGATGGCCGAGATGCGGGCAAGGATGCAGCAGC
AGCTGGACGAGTACCAGGAGCTTCTGGACATCAAGCTGGCCCTGGACATGGAGATCCACGCCTACCGCAAGCTCTTGGAGGGCGAGGAGG
AGAGGCTACGCCTGTCCCCCAGCCCTACCTCGCAGCGCAGCCGTGGCCGTGCTTCCTCTCACTCATCCCAGACACAGGGTGGGGGCAGCG
TCACCAAAAAGCGCAAACTGGAGTCCACTGAGAGCCGCAGCAGCTTCTCACAGCACGCACGCACTAGCGGGCGCGTGGCCGTGGAGGAGG
TGGATGAGGAGGGCAAGTTTGTCCGGCTGCGCAACAAGTCCAATGAGGACCAGTCCATGGGCAATTGGCAGATCAAGCGCCAGAATGGAG
ATGATCCCTTGCTGACTTACCGGTTCCCACCAAAGTTCACCCTGAAGGCTGGGCAGGTGGTGACGATCTGGGCTGCAGGAGCTGGGGCCA
CCCACAGCCCCCCTACCGACCTGGTGTGGAAGGCACAGAACACCTGGGGCTGCGGGAACAGCCTGCGTACGGCTCTCATCAACTCCACTG
GGGAAGAAGTGGCCATGCGCAAGCTGGTGCGCTCAGTGACTGTGGTTGAGGACGACGAGGATGAGGATGGAGATGACCTGCTCCATCACC
ACCACGTGAGTGGTAGCCGCCGCTGAGGCCGAGCCTGCACTGGGGCCACCCAGCCAGGCCTGGGGGCAGCCTCTCCCCAGCCTCCCCGTG

>2980_2980_6_AGPS-LMNA_AGPS_chr2_178310354_ENST00000264167_LMNA_chr1_156104595_ENST00000368301_length(amino acids)=675AA_BP=315
MVAPGAALSDLSPAPSGSGRQHKAVAMAEAAAAAGGTGLGAGASYGSAADRDRDPDPDRAGRRLRVLSGHLLGRPREALSTNECKARRAA
SAATAAPTATPAAQESGTIPKKRQEVMKWNGWGYNDSKFIFNKKGQIELTGKRYPLSGMGLPTFKEWIQNTLGVNVEHKTTSKASLNPSD
TPPSVVNEDFLHDLKETNISYSQEADDRVFRAHGHCLHEIFLLREGMFERIPDIVLWPTCHDDVVKIVNLACKYNLCIIPIGGGTSVSYG
LMCPADETRTIISLDTSQMNRILWVDENNLTAHVEAGITGQELERQELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVE
QYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAE
MRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTS
GRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLR

--------------------------------------------------------------
>2980_2980_7_AGPS-LMNA_AGPS_chr2_178310354_ENST00000264167_LMNA_chr1_156104595_ENST00000392353_length(transcript)=2197nt_BP=1016nt
GTGAAGCTCCAGACGCATGGCACCCGCCGCCAAGTCGCCGCGGTGGCTGCCGGGATGCGCCGCAGCGAATGGTCGCGCCGGGCGCCGCTC
TGAGTGACCTTTCACCCGCGCCCAGCGGTTCCGGGCGGCAGCACAAGGCGGTAGCCATGGCGGAGGCGGCGGCTGCAGCGGGTGGGACTG
GCTTGGGCGCGGGCGCGAGCTACGGGTCTGCAGCGGACCGGGACCGGGACCCGGACCCGGACCGCGCCGGGCGGAGGCTGCGGGTTCTCT
CTGGCCATCTGCTGGGCCGGCCCCGGGAGGCTCTGAGTACCAATGAGTGCAAAGCGCGGAGAGCCGCGTCGGCGGCCACGGCAGCGCCCA
CGGCCACTCCCGCCGCGCAGGAGTCGGGCACCATCCCAAAGAAGCGGCAAGAAGTTATGAAATGGAATGGATGGGGATATAATGATTCTA
AATTCATCTTCAATAAGAAGGGCCAAATTGAATTGACTGGGAAAAGGTACCCTCTTAGTGGCATGGGTTTACCAACATTTAAAGAATGGA
TCCAAAATACCCTTGGAGTAAATGTGGAGCATAAAACTACCTCTAAAGCATCCTTAAATCCTAGTGATACACCTCCTTCTGTTGTAAATG
AAGATTTTCTTCATGACCTTAAAGAAACTAATATTTCATATTCACAAGAGGCAGATGATCGAGTATTTAGAGCTCATGGTCATTGTCTTC
ATGAGATATTTTTGCTCAGGGAAGGAATGTTTGAGCGAATTCCTGATATAGTTTTATGGCCAACATGCCATGATGATGTAGTTAAGATTG
TGAATCTAGCTTGCAAATATAATCTTTGTATCATACCAATTGGTGGAGGAACAAGTGTTTCATATGGCCTGATGTGTCCTGCAGATGAGA
CAAGAACAATTATTTCTTTGGACACTTCACAAATGAATCGAATTCTCTGGGTTGATGAGAACAATTTGACAGCTCATGTAGAGGCTGGCA
TAACAGGACAAGAGTTGGAAAGACAGGAGCTGCGTGAGACCAAGCGCCGTCATGAGACCCGACTGGTGGAGATTGACAATGGGAAGCAGC
GTGAGTTTGAGAGCCGGCTGGCGGATGCGCTGCAGGAACTGCGGGCCCAGCATGAGGACCAGGTGGAGCAGTATAAGAAGGAGCTGGAGA
AGACTTATTCTGCCAAGCTGGACAATGCCAGGCAGTCTGCTGAGAGGAACAGCAACCTGGTGGGGGCTGCCCACGAGGAGCTGCAGCAGT
CGCGCATCCGCATCGACAGCCTCTCTGCCCAGCTCAGCCAGCTCCAGAAGCAGCTGGCAGCCAAGGAGGCGAAGCTTCGAGACCTGGAGG
ACTCACTGGCCCGTGAGCGGGACACCAGCCGGCGGCTGCTGGCGGAAAAGGAGCGGGAGATGGCCGAGATGCGGGCAAGGATGCAGCAGC
AGCTGGACGAGTACCAGGAGCTTCTGGACATCAAGCTGGCCCTGGACATGGAGATCCACGCCTACCGCAAGCTCTTGGAGGGCGAGGAGG
AGAGGCTACGCCTGTCCCCCAGCCCTACCTCGCAGCGCAGCCGTGGCCGTGCTTCCTCTCACTCATCCCAGACACAGGGTGGGGGCAGCG
TCACCAAAAAGCGCAAACTGGAGTCCACTGAGAGCCGCAGCAGCTTCTCACAGCACGCACGCACTAGCGGGCGCGTGGCCGTGGAGGAGG
TGGATGAGGAGGGCAAGTTTGTCCGGCTGCGCAACAAGTCCAATGAGGACCAGTCCATGGGCAATTGGCAGATCAAGCGCCAGAATGGAG
ATGATCCCTTGCTGACTTACCGGTTCCCACCAAAGTTCACCCTGAAGGCTGGGCAGGTGGTGACGATCTGGGCTGCAGGAGCTGGGGCCA
CCCACAGCCCCCCTACCGACCTGGTGTGGAAGGCACAGAACACCTGGGGCTGCGGGAACAGCCTGCGTACGGCTCTCATCAACTCCACTG
GGGAAGAAGTGGCCATGCGCAAGCTGGTGCGCTCAGTGACTGTGGTTGAGGACGACGAGGATGAGGATGGAGATGACCTGCTCCATCACC
ACCACGTGAGTGGTAGCCGCCGCTGAGGCCGAGCCTGCACTGGGGCCACCCAGCCAGGCCTGGGGGCAGCCTCTCCCCAGCCTCCCCGTG

>2980_2980_7_AGPS-LMNA_AGPS_chr2_178310354_ENST00000264167_LMNA_chr1_156104595_ENST00000392353_length(amino acids)=675AA_BP=315
MVAPGAALSDLSPAPSGSGRQHKAVAMAEAAAAAGGTGLGAGASYGSAADRDRDPDPDRAGRRLRVLSGHLLGRPREALSTNECKARRAA
SAATAAPTATPAAQESGTIPKKRQEVMKWNGWGYNDSKFIFNKKGQIELTGKRYPLSGMGLPTFKEWIQNTLGVNVEHKTTSKASLNPSD
TPPSVVNEDFLHDLKETNISYSQEADDRVFRAHGHCLHEIFLLREGMFERIPDIVLWPTCHDDVVKIVNLACKYNLCIIPIGGGTSVSYG
LMCPADETRTIISLDTSQMNRILWVDENNLTAHVEAGITGQELERQELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVE
QYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAE
MRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTS
GRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLR

--------------------------------------------------------------
>2980_2980_8_AGPS-LMNA_AGPS_chr2_178310354_ENST00000264167_LMNA_chr1_156104595_ENST00000448611_length(transcript)=2612nt_BP=1016nt
GTGAAGCTCCAGACGCATGGCACCCGCCGCCAAGTCGCCGCGGTGGCTGCCGGGATGCGCCGCAGCGAATGGTCGCGCCGGGCGCCGCTC
TGAGTGACCTTTCACCCGCGCCCAGCGGTTCCGGGCGGCAGCACAAGGCGGTAGCCATGGCGGAGGCGGCGGCTGCAGCGGGTGGGACTG
GCTTGGGCGCGGGCGCGAGCTACGGGTCTGCAGCGGACCGGGACCGGGACCCGGACCCGGACCGCGCCGGGCGGAGGCTGCGGGTTCTCT
CTGGCCATCTGCTGGGCCGGCCCCGGGAGGCTCTGAGTACCAATGAGTGCAAAGCGCGGAGAGCCGCGTCGGCGGCCACGGCAGCGCCCA
CGGCCACTCCCGCCGCGCAGGAGTCGGGCACCATCCCAAAGAAGCGGCAAGAAGTTATGAAATGGAATGGATGGGGATATAATGATTCTA
AATTCATCTTCAATAAGAAGGGCCAAATTGAATTGACTGGGAAAAGGTACCCTCTTAGTGGCATGGGTTTACCAACATTTAAAGAATGGA
TCCAAAATACCCTTGGAGTAAATGTGGAGCATAAAACTACCTCTAAAGCATCCTTAAATCCTAGTGATACACCTCCTTCTGTTGTAAATG
AAGATTTTCTTCATGACCTTAAAGAAACTAATATTTCATATTCACAAGAGGCAGATGATCGAGTATTTAGAGCTCATGGTCATTGTCTTC
ATGAGATATTTTTGCTCAGGGAAGGAATGTTTGAGCGAATTCCTGATATAGTTTTATGGCCAACATGCCATGATGATGTAGTTAAGATTG
TGAATCTAGCTTGCAAATATAATCTTTGTATCATACCAATTGGTGGAGGAACAAGTGTTTCATATGGCCTGATGTGTCCTGCAGATGAGA
CAAGAACAATTATTTCTTTGGACACTTCACAAATGAATCGAATTCTCTGGGTTGATGAGAACAATTTGACAGCTCATGTAGAGGCTGGCA
TAACAGGACAAGAGTTGGAAAGACAGGAGCTGCGTGAGACCAAGCGCCGTCATGAGACCCGACTGGTGGAGATTGACAATGGGAAGCAGC
GTGAGTTTGAGAGCCGGCTGGCGGATGCGCTGCAGGAACTGCGGGCCCAGCATGAGGACCAGGTGGAGCAGTATAAGAAGGAGCTGGAGA
AGACTTATTCTGCCAAGCTGGACAATGCCAGGCAGTCTGCTGAGAGGAACAGCAACCTGGTGGGGGCTGCCCACGAGGAGCTGCAGCAGT
CGCGCATCCGCATCGACAGCCTCTCTGCCCAGCTCAGCCAGCTCCAGAAGCAGCTGGCAGCCAAGGAGGCGAAGCTTCGAGACCTGGAGG
ACTCACTGGCCCGTGAGCGGGACACCAGCCGGCGGCTGCTGGCGGAAAAGGAGCGGGAGATGGCCGAGATGCGGGCAAGGATGCAGCAGC
AGCTGGACGAGTACCAGGAGCTTCTGGACATCAAGCTGGCCCTGGACATGGAGATCCACGCCTACCGCAAGCTCTTGGAGGGCGAGGAGG
AGAGGCTACGCCTGTCCCCCAGCCCTACCTCGCAGCGCAGCCGTGGCCGTGCTTCCTCTCACTCATCCCAGACACAGGGTGGGGGCAGCG
TCACCAAAAAGCGCAAACTGGAGTCCACTGAGAGCCGCAGCAGCTTCTCACAGCACGCACGCACTAGCGGGCGCGTGGCCGTGGAGGAGG
TGGATGAGGAGGGCAAGTTTGTCCGGCTGCGCAACAAGTCCAATGAGGACCAGTCCATGGGCAATTGGCAGATCAAGCGCCAGAATGGAG
ATGATCCCTTGCTGACTTACCGGTTCCCACCAAAGTTCACCCTGAAGGCTGGGCAGGTGGTGACGATCTGGGCTGCAGGAGCTGGGGCCA
CCCACAGCCCCCCTACCGACCTGGTGTGGAAGGCACAGAACACCTGGGGCTGCGGGAACAGCCTGCGTACGGCTCTCATCAACTCCACTG
GGGAAGAAGTGGCCATGCGCAAGCTGGTGCGCTCAGTGACTGTGGTTGAGGACGACGAGGATGAGGATGGAGATGACCTGCTCCATCACC
ACCACGGCTCCCACTGCAGCAGCTCGGGGGACCCCGCTGAGTACAACCTGCGCTCGCGCACCGTGCTGTGCGGGACCTGCGGGCAGCCTG
CCGACAAGGCATCTGCCAGCGGCTCAGGAGCCCAGGTGGGCGGACCCATCTCCTCTGGCTCTTCTGCCTCCAGTGTCACGGTCACTCGCA
GCTACCGCAGTGTGGGGGGCAGTGGGGGTGGCAGCTTCGGGGACAATCTGGTCACCCGCTCCTACCTCCTGGGCAACTCCAGCCCCCGAA
CCCAGAGCCCCCAGAACTGCAGCATCATACAAGAGATGGGAATGAGGTGGGAGGTGGAAGAAGGGAGAAGAAAGGTGAGTTTGAGCTGCC
TTCCCTAGCTTTAGACCCTGGGTGGGCTCTGTGCAGTCACTGGAGGTTGAAGCCAAGTGGGGTGCTGGGAGGAGGGAGAGGGAGGTCACT
GGAAAGGGGAGAGCCTGCTGGCACCCACCGTGGAGGAGGAAGGCAAGAGGGGGTGGAGGGGTGTGGCAGTGGTTTTGGCAAACGCTAAAG

>2980_2980_8_AGPS-LMNA_AGPS_chr2_178310354_ENST00000264167_LMNA_chr1_156104595_ENST00000448611_length(amino acids)=789AA_BP=315
MVAPGAALSDLSPAPSGSGRQHKAVAMAEAAAAAGGTGLGAGASYGSAADRDRDPDPDRAGRRLRVLSGHLLGRPREALSTNECKARRAA
SAATAAPTATPAAQESGTIPKKRQEVMKWNGWGYNDSKFIFNKKGQIELTGKRYPLSGMGLPTFKEWIQNTLGVNVEHKTTSKASLNPSD
TPPSVVNEDFLHDLKETNISYSQEADDRVFRAHGHCLHEIFLLREGMFERIPDIVLWPTCHDDVVKIVNLACKYNLCIIPIGGGTSVSYG
LMCPADETRTIISLDTSQMNRILWVDENNLTAHVEAGITGQELERQELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVE
QYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAE
MRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTS
GRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLR
TALINSTGEEVAMRKLVRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASASGSGAQVGGPISSGSSA

--------------------------------------------------------------
>2980_2980_9_AGPS-LMNA_AGPS_chr2_178310354_ENST00000264167_LMNA_chr1_156104595_ENST00000473598_length(transcript)=2569nt_BP=1016nt
GTGAAGCTCCAGACGCATGGCACCCGCCGCCAAGTCGCCGCGGTGGCTGCCGGGATGCGCCGCAGCGAATGGTCGCGCCGGGCGCCGCTC
TGAGTGACCTTTCACCCGCGCCCAGCGGTTCCGGGCGGCAGCACAAGGCGGTAGCCATGGCGGAGGCGGCGGCTGCAGCGGGTGGGACTG
GCTTGGGCGCGGGCGCGAGCTACGGGTCTGCAGCGGACCGGGACCGGGACCCGGACCCGGACCGCGCCGGGCGGAGGCTGCGGGTTCTCT
CTGGCCATCTGCTGGGCCGGCCCCGGGAGGCTCTGAGTACCAATGAGTGCAAAGCGCGGAGAGCCGCGTCGGCGGCCACGGCAGCGCCCA
CGGCCACTCCCGCCGCGCAGGAGTCGGGCACCATCCCAAAGAAGCGGCAAGAAGTTATGAAATGGAATGGATGGGGATATAATGATTCTA
AATTCATCTTCAATAAGAAGGGCCAAATTGAATTGACTGGGAAAAGGTACCCTCTTAGTGGCATGGGTTTACCAACATTTAAAGAATGGA
TCCAAAATACCCTTGGAGTAAATGTGGAGCATAAAACTACCTCTAAAGCATCCTTAAATCCTAGTGATACACCTCCTTCTGTTGTAAATG
AAGATTTTCTTCATGACCTTAAAGAAACTAATATTTCATATTCACAAGAGGCAGATGATCGAGTATTTAGAGCTCATGGTCATTGTCTTC
ATGAGATATTTTTGCTCAGGGAAGGAATGTTTGAGCGAATTCCTGATATAGTTTTATGGCCAACATGCCATGATGATGTAGTTAAGATTG
TGAATCTAGCTTGCAAATATAATCTTTGTATCATACCAATTGGTGGAGGAACAAGTGTTTCATATGGCCTGATGTGTCCTGCAGATGAGA
CAAGAACAATTATTTCTTTGGACACTTCACAAATGAATCGAATTCTCTGGGTTGATGAGAACAATTTGACAGCTCATGTAGAGGCTGGCA
TAACAGGACAAGAGTTGGAAAGACAGGAGCTGCGTGAGACCAAGCGCCGTCATGAGACCCGACTGGTGGAGATTGACAATGGGAAGCAGC
GTGAGTTTGAGAGCCGGCTGGCGGATGCGCTGCAGGAACTGCGGGCCCAGCATGAGGACCAGGTGGAGCAGTATAAGAAGGAGCTGGAGA
AGACTTATTCTGCCAAGCTGGACAATGCCAGGCAGTCTGCTGAGAGGAACAGCAACCTGGTGGGGGCTGCCCACGAGGAGCTGCAGCAGT
CGCGCATCCGCATCGACAGCCTCTCTGCCCAGCTCAGCCAGCTCCAGAAGCAGCTGGCAGCCAAGGAGGCGAAGCTTCGAGACCTGGAGG
ACTCACTGGCCCGTGAGCGGGACACCAGCCGGCGGCTGCTGGCGGAAAAGGAGCGGGAGATGGCCGAGATGCGGGCAAGGATGCAGCAGC
AGCTGGACGAGTACCAGGAGCTTCTGGACATCAAGCTGGCCCTGGACATGGAGATCCACGCCTACCGCAAGCTCTTGGAGGGCGAGGAGG
AGAGGCTACGCCTGTCCCCCAGCCCTACCTCGCAGCGCAGCCGTGGCCGTGCTTCCTCTCACTCATCCCAGACACAGGGTGGGGGCAGCG
TCACCAAAAAGCGCAAACTGGAGTCCACTGAGAGCCGCAGCAGCTTCTCACAGCACGCACGCACTAGCGGGCGCGTGGCCGTGGAGGAGG
TGGATGAGGAGGGCAAGTTTGTCCGGCTGCGCAACAAGTCCAATGAGGACCAGTCCATGGGCAATTGGCAGATCAAGCGCCAGAATGGAG
ATGATCCCTTGCTGACTTACCGGTTCCCACCAAAGTTCACCCTGAAGGCTGGGCAGGTGGTGACGATCTGGGCTGCAGGAGCTGGGGCCA
CCCACAGCCCCCCTACCGACCTGGTGTGGAAGGCACAGAACACCTGGGGCTGCGGGAACAGCCTGCGTACGGCTCTCATCAACTCCACTG
GGGAAGAAGTGGCCATGCGCAAGCTGGTGCGCTCAGTGACTGTGGTTGAGGACGACGAGGATGAGGATGGAGATGACCTGCTCCATCACC
ACCACGGCTCCCACTGCAGCAGCTCGGGGGACCCCGCTGAGTACAACCTGCGCTCGCGCACCGTGCTGTGCGGGACCTGCGGGCAGCCTG
CCGACAAGGCATCTGCCAGCGGCTCAGGAGCCCAGGTGGGCGGACCCATCTCCTCTGGCTCTTCTGCCTCCAGTGTCACGGTCACTCGCA
GCTACCGCAGTGTGGGGGGCAGTGGGGGTGGCAGCTTCGGGGACAATCTGGTCACCCGCTCCTACCTCCTGGGCAACTCCAGCCCCCGAA
CCCAGAGCCCCCAGAACTGCAGCATCATGTAATCTGGGACCTGCCAGGCAGGGGTGGGGGTGGAGGCTTCCTGCGTCCTCCTCACCTCAT
GCCCACCCCCTGCCCTGCACGTCATGGGAGGGGGCTTGAAGCCAAAGAAAAATAACCCTTTGGTTTTTTTCTTCTGTATTTTTTTTTCTA

>2980_2980_9_AGPS-LMNA_AGPS_chr2_178310354_ENST00000264167_LMNA_chr1_156104595_ENST00000473598_length(amino acids)=767AA_BP=315
MVAPGAALSDLSPAPSGSGRQHKAVAMAEAAAAAGGTGLGAGASYGSAADRDRDPDPDRAGRRLRVLSGHLLGRPREALSTNECKARRAA
SAATAAPTATPAAQESGTIPKKRQEVMKWNGWGYNDSKFIFNKKGQIELTGKRYPLSGMGLPTFKEWIQNTLGVNVEHKTTSKASLNPSD
TPPSVVNEDFLHDLKETNISYSQEADDRVFRAHGHCLHEIFLLREGMFERIPDIVLWPTCHDDVVKIVNLACKYNLCIIPIGGGTSVSYG
LMCPADETRTIISLDTSQMNRILWVDENNLTAHVEAGITGQELERQELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVE
QYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAE
MRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTS
GRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLR
TALINSTGEEVAMRKLVRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASASGSGAQVGGPISSGSSA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for AGPS-LMNA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	LMNA	chr2:178310354	chr1:156104595	ENST00000347559		2	11	1_130	213.0	635.0	MLIP
Tgene	LMNA	chr2:178310354	chr1:156104595	ENST00000361308		2	10	1_130	213.0	573.0	MLIP
Tgene	LMNA	chr2:178310354	chr1:156104595	ENST00000368300		2	12	1_130	213.0	665.0	MLIP
Tgene	LMNA	chr2:178310354	chr1:156104595	ENST00000368301		5	13	1_130	213.0	573.0	MLIP
Tgene	LMNA	chr2:178310354	chr1:156104595	ENST00000448611		2	13	1_130	101.0	575.0	MLIP

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for AGPS-LMNA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for AGPS-LMNA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	AGPS	C0282529	Chondrodysplasia Punctata, Rhizomelic	11	CLINGEN
Hgene	AGPS	C1838612	Rhizomelic chondrodysplasia punctata, type 3	5	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C1449563	Cardiomyopathy, Familial Idiopathic	24	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene		C1720860	Familial Partial Lipodystrophy, Type 2	19	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C0033300	Progeria	16	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene		C0410190	Autosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)	10	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C0432291	Mandibuloacral dysostosis	9	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C1720859	Familial Partial Lipodystrophy, Type 1	6	CTD_human;ORPHANET
Tgene		C0271694	Familial partial lipodystrophy	5	CTD_human;GENOMICS_ENGLAND
Tgene		C0406585	Lethal tight skin contracture syndrome (disorder)	5	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene		C0796031	Malouf syndrome	5	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C0007193	Cardiomyopathy, Dilated	4	CTD_human
Tgene		C1720861	Familial Partial Lipodystrophy, Type 3	4	CTD_human
Tgene		C2750035	Emery-Dreifuss Muscular Dystrophy 3	4	GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C2750785	MUSCULAR DYSTROPHY, CONGENITAL, LMNA-RELATED (disorder)	4	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C0410189	Muscular Dystrophy, Emery-Dreifuss	3	CTD_human
Tgene		C0686353	Muscular Dystrophies, Limb-Girdle	3	CTD_human;GENOMICS_ENGLAND
Tgene		C0751337	X-Linked Emery-Dreifuss Muscular Dystrophy	3	CTD_human
Tgene		C1450051	Autosomal Recessive Emery-Dreifuss Muscular Dystrophy	3	CTD_human;ORPHANET
Tgene		C1854154	Charcot-Marie-Tooth disease, Type 2B1	3	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene		C1857829	Heart-hand syndrome, Slovenian type	3	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene		C1832931	ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 2	2	ORPHANET
Tgene		C4275075	Atypical Werner syndrome	2	ORPHANET
Tgene		C0004245	Atrioventricular Block	1	CTD_human
Tgene		C0004331	Auriculo-Ventricular Dissociation	1	CTD_human
Tgene		C0011644	Scleroderma	1	CTD_human
Tgene		C0016508	Congenital Foot Deformity	1	CTD_human
Tgene		C0017668	Focal glomerulosclerosis	1	GENOMICS_ENGLAND
Tgene		C0018566	Congenital Hand Deformities	1	CTD_human
Tgene		C0018794	Heart Block	1	CTD_human
Tgene		C0032460	Polycystic Ovary Syndrome	1	CTD_human
Tgene		C0036420	Localized scleroderma	1	CTD_human
Tgene		C0037188	Sinoatrial Block	1	CTD_human
Tgene		C0042514	Tachycardia, Ventricular	1	CTD_human
Tgene		C0085298	Sudden Cardiac Death	1	CTD_human
Tgene		C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human
Tgene		C0263409	Linear Scleroderma	1	CTD_human
Tgene		C0376634	Craniofacial Abnormalities	1	CTD_human
Tgene		C0546264	Congenital Fiber Type Disproportion	1	GENOMICS_ENGLAND
Tgene		C0796083	Najjar syndrome	1	ORPHANET
Tgene		C1136321	HIV-Associated Lipodystrophy Syndrome	1	CTD_human
Tgene		C1136382	Sclerocystic Ovaries	1	CTD_human
Tgene		C1527383	Morphea	1	CTD_human
Tgene		C1720824	Sudden Cardiac Arrest	1	CTD_human
Tgene		C4049702	Focal Segmental Glomerulosclerosis, Not Otherwise Specified	1	GENOMICS_ENGLAND
Tgene		C4750858	LMNA-related cardiocutaneous progeria syndrome	1	ORPHANET

Fusion Gene Studies in Kim Lab

Fusion gene:AGPS-LMNA (FusionGDB2 ID:HG8540TG4000)

Fusion Gene Summary for AGPS-LMNA

Fusion Gene ORF analysis for AGPS-LMNA

Fusion Genomic Features for AGPS-LMNA

Fusion Protein Features for AGPS-LMNA

Fusion Gene Sequence for AGPS-LMNA

Fusion Gene PPI Analysis for AGPS-LMNA

Related Drugs for AGPS-LMNA

Related Diseases for AGPS-LMNA

Fusion Gene Studies
in Kim Lab