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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:EPT1_CCNI (FusionGDB2 ID:HG85465TG10983)

Fusion Gene Summary for EPT1_CCNI

Fusion gene summary

Fusion gene information	Fusion gene name: EPT1_CCNI
	Fusion gene ID: hg85465tg10983
		Hgene	Tgene
	Gene symbol	EPT1	CCNI
	Gene ID	85465	10983
	Gene name	selenoprotein I	cyclin I
	Synonyms	EPT1\|SELI\|SEPI\|SPG81	CCNI1\|CYC1\|CYI
	Cytomap	2p23.3	4q21.1
	Type of gene	protein-coding	protein-coding
	Description	ethanolaminephosphotransferase 1ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)hEPT1	cyclin-Icyclin ITI
	Modification date	20240407	20240305
	UniProtAcc	.	Q14094
	Ensembl transtripts involved in fusion gene	ENST00000260585, ENST00000462301,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 3 X 3 X 3=27	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 11 X 9 X 11=1089
	# samples	3	35
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(3/2710)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(35/108910)=-1.63757712688458 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: EPT1 [Title/Abstract] AND CCNI [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	EPT1(26596497)-CCNI(77976533), # samples:1

Fusion gene breakpoints across EPT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CCNI (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Breakpoints for EPT1_CCNI

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
EPT1	chr2	26596497	CCNI	chr4	77976533

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for EPT1_CCNI

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
EPT1-CCNI	Promoter / Enhancer Hijacking M6		Promoter swap drives cyclin I expression, activating CDK5 to inhibit apoptotic podocyte and cancer cell death.		Pan-CDK inhibitors; CDK5 inhibitors; lysosomal agents		Chemoresistant epithelial carcinomas

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
EPT1-CCNI	Promoter / Enhancer Hijacking	Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 37081792; Title: CDK6 is activated by the atypical cyclin I to promote E2F-mediated gene expression and cancer cell proliferation.	Promoter swap drives cyclin I expression, activating CDK5 to inhibit apoptotic podocyte and cancer cell death.	Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 37081792; Title: CDK6 is activated by the atypical cyclin I to promote E2F-mediated gene expression and cancer cell proliferation.	Pan-CDK inhibitors; CDK5 inhibitors; lysosomal agents		Chemoresistant epithelial carcinomas	Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 32080083; Title: Combined use of circulating tumor cells and salivary mRNA to detect non-small-cell lung cancer.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CCNI Q14094

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EPT1	GO:0006646	phosphatidylethanolamine biosynthetic process	17132865

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Fusion Genomic Features for EPT1_CCNI

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
EPT1	chr2	26596497	+	CCNI	chr4	77976533	-	9.83e-04	9.99e-01

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for EPT1_CCNI

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000260585	ENST00000237654	EPT1	chr2	26596497	+	CCNI	chr4	77976533	-
In-frame	ENST00000260585	ENST00000537948	EPT1	chr2	26596497	+	CCNI	chr4	77976533	-

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000260585	ENST00000237654	EPT1	chr2	26596497	CCNI	chr4	77976533	692	1439
ENST00000260585	ENST00000537948	EPT1	chr2	26596497	CCNI	chr4	77976533	692	415

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000260585	ENST00000237654	EPT1	chr2	26596497	CCNI	chr4	77976533	2.29e-03	9.98e-01
ENST00000260585	ENST00000537948	EPT1	chr2	26596497	CCNI	chr4	77976533	1.21e-03	9.99e-01

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

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Fusion Protein Retained/Non-Retained Functional Features for EPT1_CCNI

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

EPT1_CCNI_chr2-26596497_chr4-77976533.png

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EPT1

chr2:26596497

chr4:77976533

ENST00000260585

Q9C0D9

123_145

191.0

398.0

Transmembrane

Helical

Hgene

EPT1

chr2:26596497

chr4:77976533

ENST00000260585

Q9C0D9

150_172

191.0

398.0

Transmembrane

Helical

Hgene

EPT1

chr2:26596497

chr4:77976533

ENST00000260585

Q9C0D9

47_69

191.0

398.0

Transmembrane

Helical

Hgene

EPT1

chr2:26596497

chr4:77976533

ENST00000260585

Q9C0D9

84_103

191.0

398.0

Transmembrane

Helical

Tgene

CCNI

chr2:26596497

chr4:77976533

ENST00000237654

Q14094

367_377

153.0

378.0

Compositional bias

Pro residues

Tgene

CCNI

chr2:26596497

chr4:77976533

ENST00000237654

Q14094

357_377

153.0

378.0

Region

Disordered

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EPT1

chr2:26596497

chr4:77976533

ENST00000260585

Q9C0D9

179_201

191.0

398.0

Transmembrane

Helical

Hgene

EPT1

chr2:26596497

chr4:77976533

ENST00000260585

Q9C0D9

221_243

191.0

398.0

Transmembrane

Helical

Hgene

EPT1

chr2:26596497

chr4:77976533

ENST00000260585

Q9C0D9

256_278

191.0

398.0

Transmembrane

Helical

Hgene

EPT1

chr2:26596497

chr4:77976533

ENST00000260585

Q9C0D9

291_310

191.0

398.0

Transmembrane

Helical

Hgene

EPT1

chr2:26596497

chr4:77976533

ENST00000260585

Q9C0D9

317_339

191.0

398.0

Transmembrane

Helical

Hgene

EPT1

chr2:26596497

chr4:77976533

ENST00000260585

Q9C0D9

344_366

191.0

398.0

Transmembrane

Helical

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for EPT1_CCNI

In-frame Fusion Transcript Sequences.

>EPT1_CCNI_ENST00000260585_ENST00000237654_26596497_77976533 length=2428nt 
 Breakpoint=692nt
CTCCTACCTTCTCGGGCAGCCCAGTCTTTGCCATCCTTGCCCAGCCGGTGTGGTGCTTGTGTGTCACAGCCTTGTAGCCGGGAGTCGCTGCCGAGTGGGCGCTCAGTTTTCGGGTCGTCATGGCTGGCTACGAATACGTGAGCCCGGAGC
AGCTGGCTGGCTTTGATAAGTACAAGTACAGTGCTGTGGATACCAATCCACTTTCTCTGTATGTCATGCATCCATTCTGGAACACTATAGTAAAGGTATTTCCTACTTGGCTGGCGCCCAATCTGATAACTTTTTCTGGCTTTCTGCTGG
TCGTATTCAATTTTCTGCTAATGGCATACTTTGATCCTGACTTTTATGCCTCAGCACCAGGTCACAAGCACGTGCCTGACTGGGTTTGGATTGTAGTGGGCATCCTCAACTTCGTAGCCTACACTCTAGATGGTGTGGACGGAAAGCAAG
CTCGCAGAACCAATTCTAGCACTCCCTTAGGGGAGCTTTTTGATCATGGCCTGGATAGTTGGTCATGTGTTTACTTTGTTGTGACTGTTTATTCCATCTTTGGAAGAGGATCAACTGGTGTCAGTGTTTTTGTTCTTTATCTCCTGCTAT
GGGTAGTTTTGTTTTCTTTCATCCTGTCCCACTGGGAAAAGTATAACACAGGGATTCTTTTCCTGCCATGGGGATATGACATTAGCCAGGTGTTCCATGCCATTGCAGTGTCAACTAGGCCTCAGTTACTTTTCAGTTTGCCCAAATTGA
GCCCATCTCAACATTTGGCAGTCCTTACCAAGCAACTACTTCACTGTATGGCCTGCAACCAACTTCTGCAATTCAGAGGATCCATGCTTGCTCTGGCCATGGTTAGTCTGGAAATGGAGAAACTCATTCCTGATTGGCTTTCTCTTACAA
TTGAACTGCTTCAGAAAGCACAGATGGATAGCTCCCAGTTGATCCATTGTCGGGAGCTTGTGGCACATCACCTTTCTACTCTGCAGTCTTCCCTGCCTCTGAATTCCGTTTATGTCTACCGTCCCCTCAAGCACACCCTGGTGACCTGTG
ACAAAGGAGTGTTCAGATTACATCCCTCCTCTGTCCCAGGCCCAGACTTCTCCAAGGACAACAGCAAGCCAGAAGTGCCAGTCAGAGGTACAGCAGCCTTTTACCATCATCTCCCAGCTGCCAGTGGGTGCAAGCAGACCTCTACTAAAC
GCAAAGTAGAGGAAATGGAAGTGGATGACTTCTATGATGGAATCAAACGGCTCTATAATGAAGATAATGTCTCAGAAAATGTGGGTTCTGTGTGTGGCACTGATTTATCAAGACAAGAGGGACATGCTTCCCCTTGTCCACCTTTGCAGC
CTGTTTCTGTCATGTAGTTTCAACAAGTGCTACCTTTGAGTGTAAACTAAGGTAGACTACTTTGGGAATGAGAACATGCAAAATCAGGAAAGGCTGTAGAAGGAAATATACCTTAACAGGCTGATTTGGAGTGAGCCAGAAAAAAAAAAT
AAAACTCTCATTATTTGTGTGGCTAATTATAATTCAGCGTTATTTAAGCACATAAAGACCAAAAAAAAAAAAAAGAAATCCAAAAGATCCAAACTTTTTTTAAACTTAAAAAATCTCTTTGTAGTATGTCAGTTGCACTTTTTTTCTGCC
ATAATGTAACGTAGCTTGCCCCGTCAAAAATTCAATTAAAATTCATGGCCAGCAATCCTGTTCCCCCTCAGCATCCTGATTTAATTTTCCTGTTGCTTTTGCTTGCTTCTCCATTTAATAGTTACTGAACTTTATGCATGTTGATCTATA
TTGATTTTCACTGCAGTTGAATGAACAAATTATTTCAGTGTGACAGCCATGACTCAAGTTCCAATTAGTCTGAAAAGGGTACTTTGGAATTGTCCCATATTAATCAGAGATGGCAAAAGAAAAAGTTCTCATATTACCAGGTTGATTTTG
TGTCTCATTTCAAATTTTAATTTAAAATTATGGTTTTCATTTTTGTTTACCTTAAAGTGATGCTTAAAAGTGGCATGTAATTAGGACACTTAGGTTTGTTGAAAGCATTTTCGACATTTGTATAAAAGAATTTGTGATAAATATATCCAG
GTGCTCACCAAAGAAACATGTATTAACAACTTAAATTAGATTTTTCTAACTGATAGTTTTCACTCATTTATAATCAGTAGGAGAGACTGTCTAGATGTTGGGGCAGCTCTATGATTTAAGTCTGTAACATGTTATAACTGAATTTAGTAC
CCTAGTTTTGTTAAGCTATTAGGATTTTCTAATAGAACTTACTCCCCCTGCCTCCCCAGCCTTATGTTTCTTTTAATGACTTCTGGATCCTGAGCTCCCTTTGCAGTCTGAAAAAGGTATTGCAGTCAGAACTGTGTACTGATGATAAAA
GCCTCTGGTAGCAATAAAAAGTTGTCCT

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533 length=1451nt 
 Breakpoint=692nt
CTCCTACCTTCTCGGGCAGCCCAGTCTTTGCCATCCTTGCCCAGCCGGTGTGGTGCTTGTGTGTCACAGCCTTGTAGCCGGGAGTCGCTGCCGAGTGGGCGCTCAGTTTTCGGGTCGTCATGGCTGGCTACGAATACGTGAGCCCGGAGC
AGCTGGCTGGCTTTGATAAGTACAAGTACAGTGCTGTGGATACCAATCCACTTTCTCTGTATGTCATGCATCCATTCTGGAACACTATAGTAAAGGTATTTCCTACTTGGCTGGCGCCCAATCTGATAACTTTTTCTGGCTTTCTGCTGG
TCGTATTCAATTTTCTGCTAATGGCATACTTTGATCCTGACTTTTATGCCTCAGCACCAGGTCACAAGCACGTGCCTGACTGGGTTTGGATTGTAGTGGGCATCCTCAACTTCGTAGCCTACACTCTAGATGGTGTGGACGGAAAGCAAG
CTCGCAGAACCAATTCTAGCACTCCCTTAGGGGAGCTTTTTGATCATGGCCTGGATAGTTGGTCATGTGTTTACTTTGTTGTGACTGTTTATTCCATCTTTGGAAGAGGATCAACTGGTGTCAGTGTTTTTGTTCTTTATCTCCTGCTAT
GGGTAGTTTTGTTTTCTTTCATCCTGTCCCACTGGGAAAAGTATAACACAGGGATTCTTTTCCTGCCATGGGGATATGACATTAGCCAGGTGTTCCATGCCATTGCAGTGTCAACTAGGCCTCAGTTACTTTTCAGTTTGCCCAAATTGA
GCCCATCTCAACATTTGGCAGTCCTTACCAAGCAACTACTTCACTGTATGGCCTGCAACCAACTTCTGCAATTCAGAGGATCCATGCTTGCTCTGGCCATGGTTAGTCTGGAAATGGAGAAACTCATTCCTGATTGGCTTTCTCTTACAA
TTGAACTGCTTCAGAAAGCACAGATGGATAGCTCCCAGTTGATCCATTGTCGGGAGCTTGTGGCACATCACCTTTCTACTCTGCAGTCTTCCCTGCCTCTGAATTCCGTTTATGTCTACCGTCCCCTCAAGCACACCCTGGTGACCTGTG
ACAAAGGAGTGTTCAGATTACATCCCTCCTCTGTCCCAGGCCCAGACTTCTCCAAGGACAACAGCAAGCCAGAAGTGCCAGTCAGAGGTACAGCAGCCTTTTACCATCATCTCCCAGCTGCCAGTGGGTGCAAGCAGACCTCTACTAAAC
GCAAAGTAGAGGAAATGGAAGTGGATGACTTCTATGATGGAATCAAACGGCTCTATAATGAAGATAATGTCTCAGAAAATGTGGGTTCTGTGTGTGGCACTGATTTATCAAGACAAGAGGGACATGCTTCCCCTTGTCCACCTTTGCAGC
CTGTTTCTGTCATGTAGTTTCAACAAGTGCTACCTTTGAGTGTAAACTAAGGTAGACTACTTTGGGAATGAGAACATGCAAAATCAGGAAAGGCTGTAGAA

N-Truncated Transcript (5UTR-3CDS) Sequences

C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for EPT1_CCNI

In-frame Fusion Protein Sequences.

>EPT1_CCNI_ENST00000260585_ENST00000237654_26596497_77976533 length=1439nt
MAATQDTMSQSGAVSCCPGATNGSLGRSDGVAKMSPKDLFEQRKKYSNSNVIMHETSQYHVQLNLVMNEQKEKITEKVILSMTAKEHHKEQEEVSRLIDELQTAIKSNIGHLCKLGPQLQAEQEQFSSYVYQHIKSLPANTLVPGGLQLK
VFENGKNTGEISVGISKKDLGSDSPIQTDHMMERLLLKIHQRLQGSSINPPGLNYSSMRLFDENGQEIKNPLSLKNEQKIWVSYGRAYRSPLNLALGLTFDRVSAFARGDIMVAYKTFLDPNAVLLPGCGNWEVCEGFPINFNCTSQQIP
DQFEKVDLENHFLQNKVDPNIVLHASVSIGKWSFSGSEASSRSQIAPSILWPVASVWLITKTGMILSRAITQGCLAIGHPIRVKAAEGTSLEGYKLILQKRHSGDDSQKWVFGTDGCIYSKAYPQFVLTYLEELNAQVDVTQTEYHIHHG
AWTTAHQEHGRNLAEEVLQESASNLGLKQLPEPSDTHLMPEGSLEETGELTVALVRKLEEKHPKASAQRWAIKHEGTSKPGQWKHSRVENPLWNKLTYMWPVLPSGQLNEEFDWPIQGLLVPSSPPMKKPICKTTEPYAPVRLRVLQNGE
KNKNRSVTILGPDISPGRKTQCTEILNLPSAARRLYNEKGKEIFALKDLQRDELVYVSCGELWINPDLSIAQQKKQIFLRNLESDIAKIQIFCSTHKIEALVLEVQSDIVSGSKLAVHKPVAIFGEEKQVTEPEEKQMQEDPLTTENASS
EILDSHVRAHLRMKACHTLPRYAWQETSHDFDEDDSLPKKTEKGLFENVEPQKKHSCSPKHSKLHKHCHQQFEYRDGQIISHAAPQLVLGVQGPNLRSGMEVVLVEKKSDGSHQRWIHQEDSRTFHLVSNPDLVLAVSMTKTRNEVCGYP
VIVQKYKPYNNGAANQKWHYMKNIKALVAFHSTALDKEITSANYAGVCTSSVIKEENIDQPGYCYLSPDGKRKTMLCLACGQSMRTEKGLKQLLPGVPFLCISGTKTQKPFLQGPFKVISVAEVDLSCDKAEKTLSYYQARLLSLRMKTC
TQAASHSGMAATHQKAVKIIAYKNGDGYRNGKLIVAGTFPMLLTECTEQLGLARAASKVYTKDGTPIFTLRDLVLWALDESFLQRDSEKQKQDAAPVGKEQIIVEKNPRMKVKNRLFAKSVTSDSLDGIDKSLLTLILRNPIAIWVSCGE
PFLPPNALQKAEKLEKQNWLKKDRILADLDTMRHKMRQLKGRRVAACQPATMVPTKSPVQPVVVEGGWTEQTQQEIKLMELIRHTEAHLSEIQEMESKINFPIATKRIAVKPSNLYKQPNTKRVWIYLNGGRPEDGTYAWGKTISELLQD
CSSRLKMTHPARALYTPSGEPIQSWDDIERDMVICVSMGHGFKTPKELKQLMEIRANYARIRRQQGPQATDIVVSPSTKLLSLAHLHNX

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533 length=415nt
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVFHAIAVSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPLNSVYVY
RPLKHTLVTCDKGVFRLHPSSVPGPDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for EPT1_CCNI

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533_3-gene_p.T182I_415_T220I length=415AA
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVFHAIAVSTRPQLLFSLPKLSPSQHLAVLIKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPLNSVYVY
RPLKHTLVTCDKGVFRLHPSSVPGPDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533_3-gene_p.H152Y_415_Q190Y length=415AA
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISYVFHAIAVSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPLNSVYVY
RPLKHTLVTCDKGVFRLHPSSVPGPDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533_3-gene_p.G363E_415_G401E length=415AA
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVFHAIAVSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPLNSVYVY
RPLKHTLVTCDKGVFRLHPSSVPGPDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEEHASPCPPLQPVSVM

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533_3-gene_p.S234C_415_S272C length=415AA
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVFHAIAVSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSCQLIHCRELVAHHLSTLQSSLPLNSVYVY
RPLKHTLVTCDKGVFRLHPSSVPGPDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533_3-gene_p.R301T_415_R339T length=415AA
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVFHAIAVSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPLNSVYVY
RPLKHTLVTCDKGVFRLHPSSVPGPDFSKDNSKPEVPVTGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533_3-gene_p.S200C_415_S238C length=415AA
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVFHAIAVSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFRGCMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPLNSVYVY
RPLKHTLVTCDKGVFRLHPSSVPGPDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533_3-gene_p.T161A_415_T199A length=415AA
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVFHAIAVSARPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPLNSVYVY
RPLKHTLVTCDKGVFRLHPSSVPGPDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533_3-gene_p.P264S_415_P302S length=415AA
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVFHAIAVSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPLNSVYVY
RSLKHTLVTCDKGVFRLHPSSVPGPDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533_3-gene_p.P296T_415_P334T length=415AA
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVFHAIAVSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPLNSVYVY
RPLKHTLVTCDKGVFRLHPSSVPGPDFSKDNSKTEVPVRGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533_3-gene_p.A190T_415_A228T length=415AA
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVFHAIAVSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMTCNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPLNSVYVY
RPLKHTLVTCDKGVFRLHPSSVPGPDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533_3-gene_p.S160P;p.S282F_415_S198P;S320F length=415AA
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVFHAIAVPTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPLNSVYVY
RPLKHTLVTCDKGVFRLHPFSVPGPDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533_3-gene_p.H177P;p.V207A_415_H215P;V245A length=415AA
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVFHAIAVSTRPQLLFSLPKLSPSQPLAVLTKQLLHCMACNQLLQFRGSMLALAMASLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPLNSVYVY
RPLKHTLVTCDKGVFRLHPSSVPGPDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533_3-gene_p.F154L;p.H187N_415_F192L;H225N length=415AA
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVLHAIAVSTRPQLLFSLPKLSPSQHLAVLTKQLLNCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPLNSVYVY
RPLKHTLVTCDKGVFRLHPSSVPGPDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533_3-gene_p.V325I_415_V363I length=415AA
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVFHAIAVSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPLNSVYVY
RPLKHTLVTCDKGVFRLHPSSVPGPDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKRKIEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533_3-gene_p.C272Y_415_C310Y length=415AA
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVFHAIAVSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPLNSVYVY
RPLKHTLVTYDKGVFRLHPSSVPGPDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533_3-gene_p.V259I_415_V297I length=415AA
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVFHAIAVSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPLNSIYVY
RPLKHTLVTCDKGVFRLHPSSVPGPDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533_3-gene_p.P170H_415_P208H length=415AA
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVFHAIAVSTRPQLLFSLHKLSPSQHLAVLTKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPLNSVYVY
RPLKHTLVTCDKGVFRLHPSSVPGPDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533_3-gene_p.R240L_415_R278L length=415AA
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVFHAIAVSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCLELVAHHLSTLQSSLPLNSVYVY
RPLKHTLVTCDKGVFRLHPSSVPGPDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533_3-gene_p.P287T_415_P325T length=415AA
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVFHAIAVSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPLNSVYVY
RPLKHTLVTCDKGVFRLHPSSVPGTDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533_3-gene_p.S248C_415_S286C length=415AA
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVFHAIAVSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCRELVAHHLCTLQSSLPLNSVYVY
RPLKHTLVTCDKGVFRLHPSSVPGPDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533_3-gene_p.R323H_415_R361H length=415AA
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVFHAIAVSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPLNSVYVY
RPLKHTLVTCDKGVFRLHPSSVPGPDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKHKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533_3-gene_p.L151F;p.Q235K_415_S189F;Q273K length=415AA
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDIFQVFHAIAVSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSKLIHCRELVAHHLSTLQSSLPLNSVYVY
RPLKHTLVTCDKGVFRLHPSSVPGPDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533_3-gene_p.S290P_415_S328P length=415AA
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVFHAIAVSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPLNSVYVY
RPLKHTLVTCDKGVFRLHPSSVPGPDFPKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533_3-gene_p.Y334C_415_Y372C length=415AA
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVFHAIAVSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPLNSVYVY
RPLKHTLVTCDKGVFRLHPSSVPGPDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFCDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

>EPT1_CCNI_ENST00000260585_ENST00000537948_26596497_77976533_3-gene_p.R323H_415_R361H length=415AA
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVWIVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTG
VSVFVLYLLLWVVLFSFILSHWEKYNTGILFLPWGYDISQVFHAIAVSTRPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDWLSLTIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPLNSVYVY
RPLKHTLVTCDKGVFRLHPSSVPGPDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKHKVEEMEVDDFYDGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM

Fusion Protein ID	Sample ID	Mutated Partner	AAchange in WT	Seq. Length	AAchange in Fusion
ENST00000260585_ENST00000537948_26596497_77976533	TCGA-19-5956-01A	3-gene	p.T182I	415	T220I
ENST00000260585_ENST00000537948_26596497_77976533	TCGA-2F-A9KO-01A	3-gene	p.H152Y	415	Q190Y
ENST00000260585_ENST00000537948_26596497_77976533	TCGA-44-3919-01A	3-gene	p.G363E	415	G401E
ENST00000260585_ENST00000537948_26596497_77976533	TCGA-49-AAQV-01A	3-gene	p.S234C	415	S272C
ENST00000260585_ENST00000537948_26596497_77976533	TCGA-55-8205-01A	3-gene	p.R301T	415	R339T
ENST00000260585_ENST00000537948_26596497_77976533	TCGA-59-2352-01A	3-gene	p.S200C	415	S238C
ENST00000260585_ENST00000537948_26596497_77976533	TCGA-69-8254-01A	3-gene	p.T161A	415	T199A
ENST00000260585_ENST00000537948_26596497_77976533	TCGA-A5-A0G2-01A	3-gene	p.P264S	415	P302S
ENST00000260585_ENST00000537948_26596497_77976533	TCGA-A5-A2K5-01A	3-gene	p.P296T	415	P334T
ENST00000260585_ENST00000537948_26596497_77976533	TCGA-AG-A002-01A	3-gene	p.A190T	415	A228T
ENST00000260585_ENST00000537948_26596497_77976533	TCGA-AP-A059-01A	3-gene	p.S160P;p.S282F	415	S198P;S320F
ENST00000260585_ENST00000537948_26596497_77976533	TCGA-AP-A1DV-01A	3-gene	p.H177P;p.V207A	415	H215P;V245A
ENST00000260585_ENST00000537948_26596497_77976533	TCGA-AX-A2HC-01A	3-gene	p.F154L;p.H187N	415	F192L;H225N
ENST00000260585_ENST00000537948_26596497_77976533	TCGA-B5-A1MR-01A	3-gene	p.V325I	415	V363I
ENST00000260585_ENST00000537948_26596497_77976533	TCGA-B5-A1MX-01A	3-gene	p.C272Y	415	C310Y
ENST00000260585_ENST00000537948_26596497_77976533	TCGA-CG-5726-01A	3-gene	p.V259I	415	V297I
ENST00000260585_ENST00000537948_26596497_77976533	TCGA-D3-A2JD-06A	3-gene	p.P170H	415	P208H
ENST00000260585_ENST00000537948_26596497_77976533	TCGA-EE-A17Y-06A	3-gene	p.R240L	415	R278L
ENST00000260585_ENST00000537948_26596497_77976533	TCGA-EE-A181-06A	3-gene	p.P287T	415	P325T
ENST00000260585_ENST00000537948_26596497_77976533	TCGA-FD-A43X-01A	3-gene	p.S248C	415	S286C
ENST00000260585_ENST00000537948_26596497_77976533	TCGA-FD-A5BY-01A	3-gene	p.R323H	415	R361H
ENST00000260585_ENST00000537948_26596497_77976533	TCGA-FS-A1ZK-06A	3-gene	p.L151F;p.Q235K	415	S189F;Q273K
ENST00000260585_ENST00000537948_26596497_77976533	TCGA-ND-A4WC-01A	3-gene	p.S290P	415	S328P
ENST00000260585_ENST00000537948_26596497_77976533	TCGA-SQ-A6I6-01A	3-gene	p.Y334C	415	Y372C
ENST00000260585_ENST00000537948_26596497_77976533	TCGA-XK-AAIW-01A	3-gene	p.R323H	415	R361H

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for EPT1_CCNI

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		STAD	TCGA-CG-5717-01A	EPT1	chr2	26596497	+	CCNI	chr4	77976533	-

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for EPT1_CCNI

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status