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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NCOA1-OPRM1 (FusionGDB2 ID:HG8648TG4988)

Fusion Gene Summary for NCOA1-OPRM1

Fusion gene summary

Fusion gene information	Fusion gene name: NCOA1-OPRM1
	Fusion gene ID: hg8648tg4988
		Hgene	Tgene
	Gene symbol	NCOA1	OPRM1
	Gene ID	8648	4988
	Gene name	nuclear receptor coactivator 1	opioid receptor mu 1
	Synonyms	F-SRC-1\|KAT13A\|RIP160\|SRC1\|bHLHe42\|bHLHe74	LMOR\|M-OR-1\|MOP\|MOR\|MOR1\|OPRM
	Cytomap	('NCOA1')('OPRM1') 2p23.3	6q25.2
	Type of gene	protein-coding	protein-coding
	Description	nuclear receptor coactivator 1Hin-2 proteinclass E basic helix-loop-helix protein 74renal carcinoma antigen NY-REN-52steroid receptor coactivator-1	mu-type opioid receptormu opiate receptormu opioid receptor hMOR-1a
	Modification date	20200313	20200322
	UniProtAcc	Q15788	.
	Ensembl transtripts involved in fusion gene	ENST00000288599, ENST00000348332, ENST00000395856, ENST00000405141, ENST00000406961, ENST00000407230, ENST00000469850, ENST00000538539,	ENST00000288599, ENST00000348332, ENST00000395856, ENST00000405141, ENST00000406961, ENST00000407230, ENST00000469850, ENST00000538539,
Fusion gene scores	* DoF score	16 X 13 X 8=1664	7 X 6 X 3=126
	# samples	17	7
	** MAII score	log2(17/1664*10)=-3.29104878200339 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NCOA1 [Title/Abstract] AND OPRM1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NCOA1(24991403)-OPRM1(154424052), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NCOA1	GO:0000435	positive regulation of transcription from RNA polymerase II promoter by galactose	10207113
Hgene	NCOA1	GO:0006351	transcription, DNA-templated	9223431
Hgene	NCOA1	GO:0045893	positive regulation of transcription, DNA-templated	11891224\|15367689
Hgene	NCOA1	GO:0045944	positive regulation of transcription by RNA polymerase II	15919756

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	CB049201	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+

Top

Fusion Gene ORF analysis for NCOA1-OPRM1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-intron	ENST00000288599	ENST00000229768	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000288599	ENST00000330432	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000288599	ENST00000337049	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000288599	ENST00000360422	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000288599	ENST00000414028	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000288599	ENST00000419506	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000288599	ENST00000428397	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000288599	ENST00000434900	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000288599	ENST00000435918	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000288599	ENST00000452687	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000288599	ENST00000518759	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000288599	ENST00000520708	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000288599	ENST00000522236	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000288599	ENST00000522555	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000288599	ENST00000523520	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000288599	ENST00000524163	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000348332	ENST00000229768	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000348332	ENST00000330432	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000348332	ENST00000337049	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000348332	ENST00000360422	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000348332	ENST00000414028	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000348332	ENST00000419506	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000348332	ENST00000428397	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000348332	ENST00000434900	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000348332	ENST00000435918	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000348332	ENST00000452687	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000348332	ENST00000518759	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000348332	ENST00000520708	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000348332	ENST00000522236	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000348332	ENST00000522555	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000348332	ENST00000523520	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000348332	ENST00000524163	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000395856	ENST00000229768	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000395856	ENST00000330432	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000395856	ENST00000337049	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000395856	ENST00000360422	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000395856	ENST00000414028	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000395856	ENST00000419506	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000395856	ENST00000428397	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000395856	ENST00000434900	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000395856	ENST00000435918	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000395856	ENST00000452687	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000395856	ENST00000518759	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000395856	ENST00000520708	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000395856	ENST00000522236	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000395856	ENST00000522555	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000395856	ENST00000523520	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000395856	ENST00000524163	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000405141	ENST00000229768	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000405141	ENST00000330432	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000405141	ENST00000337049	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000405141	ENST00000360422	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000405141	ENST00000414028	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000405141	ENST00000419506	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000405141	ENST00000428397	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000405141	ENST00000434900	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000405141	ENST00000435918	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000405141	ENST00000452687	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000405141	ENST00000518759	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000405141	ENST00000520708	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000405141	ENST00000522236	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000405141	ENST00000522555	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000405141	ENST00000523520	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000405141	ENST00000524163	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000406961	ENST00000229768	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000406961	ENST00000330432	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000406961	ENST00000337049	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000406961	ENST00000360422	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000406961	ENST00000414028	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000406961	ENST00000419506	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000406961	ENST00000428397	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000406961	ENST00000434900	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000406961	ENST00000435918	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000406961	ENST00000452687	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000406961	ENST00000518759	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000406961	ENST00000520708	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000406961	ENST00000522236	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000406961	ENST00000522555	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000406961	ENST00000523520	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000406961	ENST00000524163	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000407230	ENST00000229768	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000407230	ENST00000330432	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000407230	ENST00000337049	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000407230	ENST00000360422	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000407230	ENST00000414028	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000407230	ENST00000419506	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000407230	ENST00000428397	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000407230	ENST00000434900	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000407230	ENST00000435918	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000407230	ENST00000452687	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000407230	ENST00000518759	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000407230	ENST00000520708	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000407230	ENST00000522236	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000407230	ENST00000522555	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000407230	ENST00000523520	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
3UTR-intron	ENST00000407230	ENST00000524163	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000469850	ENST00000229768	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000469850	ENST00000330432	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000469850	ENST00000337049	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000469850	ENST00000360422	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000469850	ENST00000414028	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000469850	ENST00000419506	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000469850	ENST00000428397	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000469850	ENST00000434900	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000469850	ENST00000435918	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000469850	ENST00000452687	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000469850	ENST00000518759	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000469850	ENST00000520708	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000469850	ENST00000522236	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000469850	ENST00000522555	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000469850	ENST00000523520	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000469850	ENST00000524163	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000538539	ENST00000229768	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000538539	ENST00000330432	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000538539	ENST00000337049	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000538539	ENST00000360422	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000538539	ENST00000414028	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000538539	ENST00000419506	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000538539	ENST00000428397	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000538539	ENST00000434900	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000538539	ENST00000435918	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000538539	ENST00000452687	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000538539	ENST00000518759	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000538539	ENST00000520708	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000538539	ENST00000522236	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000538539	ENST00000522555	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000538539	ENST00000523520	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+
intron-intron	ENST00000538539	ENST00000524163	NCOA1	chr2	24991403	+	OPRM1	chr6	154424052	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for NCOA1-OPRM1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

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Fusion Protein Features for NCOA1-OPRM1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:24991403/:154424052)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NCOA1 Q15788	.
FUNCTION: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269\|PubMed:10449719, ECO:0000269\|PubMed:12954634, ECO:0000269\|PubMed:7481822, ECO:0000269\|PubMed:9223281, ECO:0000269\|PubMed:9223431, ECO:0000269\|PubMed:9296499, ECO:0000269\|PubMed:9427757}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for NCOA1-OPRM1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NCOA1-OPRM1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for NCOA1-OPRM1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for NCOA1-OPRM1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	NCOA1	C0006142	Malignant neoplasm of breast	1	CTD_human
Hgene	NCOA1	C0014175	Endometriosis	1	CTD_human
Hgene	NCOA1	C0024668	Mammary Neoplasms, Experimental	1	CTD_human
Hgene	NCOA1	C0027627	Neoplasm Metastasis	1	CTD_human
Hgene	NCOA1	C0033578	Prostatic Neoplasms	1	CTD_human
Hgene	NCOA1	C0269102	Endometrioma	1	CTD_human
Hgene	NCOA1	C0376358	Malignant neoplasm of prostate	1	CTD_human
Hgene	NCOA1	C0678222	Breast Carcinoma	1	CTD_human
Hgene	NCOA1	C1257931	Mammary Neoplasms, Human	1	CTD_human
Hgene	NCOA1	C1458155	Mammary Neoplasms	1	CTD_human
Hgene	NCOA1	C4704874	Mammary Carcinoma, Human	1	CTD_human
Tgene		C0001973	Alcoholic Intoxication, Chronic	6	CTD_human;PSYGENET
Tgene		C0600427	Cocaine Dependence	6	CTD_human;PSYGENET
Tgene		C0001969	Alcoholic Intoxication	5	PSYGENET
Tgene		C0011570	Mental Depression	4	PSYGENET
Tgene		C0011581	Depressive disorder	4	PSYGENET
Tgene		C0009171	Cocaine Abuse	3	CTD_human
Tgene		C0036341	Schizophrenia	3	PSYGENET
Tgene		C0085762	Alcohol abuse	3	CTD_human;PSYGENET
Tgene		C0236736	Cocaine-Related Disorders	3	CTD_human
Tgene		C0019196	Hepatitis C	2	CTD_human
Tgene		C0022333	Jacksonian Seizure	2	CTD_human
Tgene		C0027796	Neuralgia	2	CTD_human
Tgene		C0033975	Psychotic Disorders	2	PSYGENET
Tgene		C0036572	Seizures	2	CTD_human
Tgene		C0038870	Neuralgia, Supraorbital	2	CTD_human
Tgene		C0042656	Neuralgia, Vidian	2	CTD_human
Tgene		C0149958	Complex partial seizures	2	CTD_human
Tgene		C0234247	Neuralgia, Atypical	2	CTD_human
Tgene		C0234249	Neuralgia, Stump	2	CTD_human
Tgene		C0234533	Generalized seizures	2	CTD_human
Tgene		C0234535	Clonic Seizures	2	CTD_human
Tgene		C0270824	Visual seizure	2	CTD_human
Tgene		C0270844	Tonic Seizures	2	CTD_human
Tgene		C0270846	Epileptic drop attack	2	CTD_human
Tgene		C0349204	Nonorganic psychosis	2	PSYGENET
Tgene		C0422850	Seizures, Somatosensory	2	CTD_human
Tgene		C0422852	Seizures, Auditory	2	CTD_human
Tgene		C0422853	Olfactory seizure	2	CTD_human
Tgene		C0422854	Gustatory seizure	2	CTD_human
Tgene		C0422855	Vertiginous seizure	2	CTD_human
Tgene		C0423711	Neuralgia, Perineal	2	CTD_human
Tgene		C0423712	Neuralgia, Iliohypogastric Nerve	2	CTD_human
Tgene		C0494475	Tonic - clonic seizures	2	CTD_human
Tgene		C0751056	Non-epileptic convulsion	2	CTD_human
Tgene		C0751110	Single Seizure	2	CTD_human
Tgene		C0751123	Atonic Absence Seizures	2	CTD_human
Tgene		C0751371	Neuralgia, Ilioinguinal	2	CTD_human
Tgene		C0751372	Nerve Pain	2	CTD_human
Tgene		C0751373	Paroxysmal Nerve Pain	2	CTD_human
Tgene		C0751494	Convulsive Seizures	2	CTD_human
Tgene		C0751495	Seizures, Focal	2	CTD_human
Tgene		C0751496	Seizures, Sensory	2	CTD_human
Tgene		C3495874	Nonepileptic Seizures	2	CTD_human
Tgene		C4048158	Convulsions	2	CTD_human
Tgene		C4316903	Absence Seizures	2	CTD_human
Tgene		C4317109	Epileptic Seizures	2	CTD_human
Tgene		C4317123	Myoclonic Seizures	2	CTD_human
Tgene		C4505436	Generalized Absence Seizures	2	CTD_human
Tgene		C0001849	AIDS Dementia Complex	1	CTD_human
Tgene		C0001956	Alcohol Use Disorder	1	CTD_human
Tgene		C0009806	Constipation	1	CTD_human
Tgene		C0013146	Drug abuse	1	CTD_human
Tgene		C0013170	Drug habituation	1	CTD_human
Tgene		C0013222	Drug Use Disorders	1	CTD_human
Tgene		C0013384	Dyskinetic syndrome	1	CTD_human
Tgene		C0014544	Epilepsy	1	CTD_human
Tgene		C0019147	Hepatic Coma	1	CTD_human
Tgene		C0019151	Hepatic Encephalopathy	1	CTD_human
Tgene		C0019337	Heroin Dependence	1	CTD_human
Tgene		C0020429	Hyperalgesia	1	CTD_human
Tgene		C0020651	Hypotension, Orthostatic	1	CTD_human
Tgene		C0026552	Morphine Dependence	1	CTD_human
Tgene		C0026650	Movement Disorders	1	CTD_human
Tgene		C0027497	Nausea	1	CTD_human
Tgene		C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
Tgene		C0033774	Pruritus	1	CTD_human
Tgene		C0033937	Psychoses, Drug	1	CTD_human
Tgene		C0033941	Psychoses, Substance-Induced	1	CTD_human
Tgene		C0035229	Respiratory Insufficiency	1	CTD_human
Tgene		C0038580	Substance Dependence	1	CTD_human
Tgene		C0038586	Substance Use Disorders	1	CTD_human
Tgene		C0086237	Epilepsy, Cryptogenic	1	CTD_human
Tgene		C0152115	Lingual-Facial-Buccal Dyskinesia	1	CTD_human
Tgene		C0206019	HIV Encephalopathy	1	CTD_human
Tgene		C0221074	Depression, Postpartum	1	PSYGENET
Tgene		C0221169	Hemiballismus	1	CTD_human
Tgene		C0232766	Asterixis	1	CTD_human
Tgene		C0233477	Dysphoric mood	1	PSYGENET
Tgene		C0235063	Respiratory Depression	1	CTD_human
Tgene		C0236018	Aura	1	CTD_human
Tgene		C0236733	Amphetamine-Related Disorders	1	CTD_human
Tgene		C0236804	Amphetamine Addiction	1	CTD_human
Tgene		C0236807	Amphetamine Abuse	1	CTD_human
Tgene		C0236969	Substance-Related Disorders	1	CTD_human
Tgene		C0237326	Dyschezia	1	CTD_human
Tgene		C0243010	Viral Encephalitis	1	CTD_human
Tgene		C0266487	Etat Marbre	1	CTD_human
Tgene		C0427086	Involuntary Movements	1	CTD_human
Tgene		C0454606	Oral Dyskinesia	1	CTD_human
Tgene		C0458247	Allodynia	1	CTD_human
Tgene		C0600241	heroin abuse	1	CTD_human
Tgene		C0600272	Morphine Abuse	1	CTD_human
Tgene		C0740858	Substance abuse problem	1	CTD_human
Tgene		C0751111	Awakening Epilepsy	1	CTD_human
Tgene		C0751197	Fulminant Hepatic Failure with Cerebral Edema	1	CTD_human
Tgene		C0751198	Hepatic Stupor	1	CTD_human
Tgene		C0751211	Hyperalgesia, Primary	1	CTD_human
Tgene		C0751212	Hyperalgesia, Secondary	1	CTD_human
Tgene		C0751213	Tactile Allodynia	1	CTD_human
Tgene		C0751214	Hyperalgesia, Thermal	1	CTD_human
Tgene		C0752196	Ballismus	1	CTD_human
Tgene		C0936243	HIV-1-Associated Cognitive Motor Complex	1	CTD_human
Tgene		C1145670	Respiratory Failure	1	CTD_human
Tgene		C1257861	Colonic Inertia	1	CTD_human
Tgene		C1510472	Drug Dependence	1	CTD_human
Tgene		C1837893	SCHIZOPHRENIA 12	1	PSYGENET
Tgene		C2936719	Mechanical Allodynia	1	CTD_human
Tgene		C4316881	Prescription Drug Abuse	1	CTD_human
Tgene		C4505390	Heroin Smoking	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:NCOA1-OPRM1 (FusionGDB2 ID:HG8648TG4988)

Fusion Gene Summary for NCOA1-OPRM1

Fusion Gene ORF analysis for NCOA1-OPRM1

Fusion Genomic Features for NCOA1-OPRM1

Fusion Protein Features for NCOA1-OPRM1

Fusion Gene Sequence for NCOA1-OPRM1

Fusion Gene PPI Analysis for NCOA1-OPRM1

Related Drugs for NCOA1-OPRM1

Related Diseases for NCOA1-OPRM1

Fusion Gene Studies
in Kim Lab