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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DPM1-EZR (FusionGDB2 ID:HG8813TG7430)

Fusion Gene Summary for DPM1-EZR

check button Fusion gene summary
Fusion gene informationFusion gene name: DPM1-EZR
Fusion gene ID: hg8813tg7430
HgeneTgene
Gene symbol

DPM1

EZR

Gene ID

8813

7430

Gene namedolichyl-phosphate mannosyltransferase subunit 1, catalyticezrin
SynonymsCDGIE|MPDSCVIL|CVL|HEL-S-105|VIL2
Cytomap('DPM1')('EZR')

20q13.13

6q25.3

Type of geneprotein-codingprotein-coding
Descriptiondolichol-phosphate mannosyltransferase subunit 1DPM synthase complex, catalytic subunitDPM synthase subunit 1MPD synthase subunit 1dolichol monophosphate mannose synthasedolichol-phosphate mannose synthase subunit 1dolichyl-phosphate beta-D-mannosylezrincytovillin 2epididymis secretory protein Li 105p81villin 2 (ezrin)
Modification date2020031320200322
UniProtAcc

O60762

P15311

Ensembl transtripts involved in fusion geneENST00000371582, ENST00000371583, 
ENST00000371588, ENST00000466152, 
Fusion gene scores* DoF score11 X 8 X 6=52825 X 24 X 6=3600
# samples 1327
** MAII scorelog2(13/528*10)=-2.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/3600*10)=-3.73696559416621
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DPM1 [Title/Abstract] AND EZR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDPM1(49574900)-EZR(159197536), # samples:3
Anticipated loss of major functional domain due to fusion event.DPM1-EZR seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
DPM1-EZR seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DPM1-EZR seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
DPM1-EZR seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDPM1

GO:0006506

GPI anchor biosynthetic process

9535917|9724629|10835346

HgeneDPM1

GO:0019348

dolichol metabolic process

9535917|9724629

HgeneDPM1

GO:0035268

protein mannosylation

9535917

HgeneDPM1

GO:0035269

protein O-linked mannosylation

9535917

TgeneEZR

GO:0048015

phosphatidylinositol-mediated signaling

25591774

TgeneEZR

GO:0051017

actin filament bundle assembly

10793131



check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0B2-01ADPM1chr20

49574900

-EZRchr6

159197536

-
ChimerDB4BRCATCGA-BH-A0B2DPM1chr20

49574899

-EZRchr6

159197536

-


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Fusion Gene ORF analysis for DPM1-EZR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000371582ENST00000476189DPM1chr20

49574900

-EZRchr6

159197536

-
5CDS-intronENST00000371582ENST00000476189DPM1chr20

49574899

-EZRchr6

159197536

-
5CDS-intronENST00000371583ENST00000476189DPM1chr20

49574900

-EZRchr6

159197536

-
5CDS-intronENST00000371583ENST00000476189DPM1chr20

49574899

-EZRchr6

159197536

-
5CDS-intronENST00000371588ENST00000476189DPM1chr20

49574900

-EZRchr6

159197536

-
5CDS-intronENST00000371588ENST00000476189DPM1chr20

49574899

-EZRchr6

159197536

-
5UTR-3CDSENST00000466152ENST00000337147DPM1chr20

49574900

-EZRchr6

159197536

-
5UTR-3CDSENST00000466152ENST00000337147DPM1chr20

49574899

-EZRchr6

159197536

-
5UTR-3CDSENST00000466152ENST00000367075DPM1chr20

49574900

-EZRchr6

159197536

-
5UTR-3CDSENST00000466152ENST00000367075DPM1chr20

49574899

-EZRchr6

159197536

-
5UTR-3CDSENST00000466152ENST00000392177DPM1chr20

49574900

-EZRchr6

159197536

-
5UTR-3CDSENST00000466152ENST00000392177DPM1chr20

49574899

-EZRchr6

159197536

-
5UTR-intronENST00000466152ENST00000476189DPM1chr20

49574900

-EZRchr6

159197536

-
5UTR-intronENST00000466152ENST00000476189DPM1chr20

49574899

-EZRchr6

159197536

-
Frame-shiftENST00000371582ENST00000337147DPM1chr20

49574900

-EZRchr6

159197536

-
Frame-shiftENST00000371582ENST00000337147DPM1chr20

49574899

-EZRchr6

159197536

-
Frame-shiftENST00000371582ENST00000367075DPM1chr20

49574900

-EZRchr6

159197536

-
Frame-shiftENST00000371582ENST00000367075DPM1chr20

49574899

-EZRchr6

159197536

-
Frame-shiftENST00000371582ENST00000392177DPM1chr20

49574900

-EZRchr6

159197536

-
Frame-shiftENST00000371582ENST00000392177DPM1chr20

49574899

-EZRchr6

159197536

-
Frame-shiftENST00000371583ENST00000337147DPM1chr20

49574900

-EZRchr6

159197536

-
Frame-shiftENST00000371583ENST00000337147DPM1chr20

49574899

-EZRchr6

159197536

-
Frame-shiftENST00000371583ENST00000367075DPM1chr20

49574900

-EZRchr6

159197536

-
Frame-shiftENST00000371583ENST00000367075DPM1chr20

49574899

-EZRchr6

159197536

-
Frame-shiftENST00000371583ENST00000392177DPM1chr20

49574900

-EZRchr6

159197536

-
Frame-shiftENST00000371583ENST00000392177DPM1chr20

49574899

-EZRchr6

159197536

-
Frame-shiftENST00000371588ENST00000337147DPM1chr20

49574900

-EZRchr6

159197536

-
Frame-shiftENST00000371588ENST00000337147DPM1chr20

49574899

-EZRchr6

159197536

-
Frame-shiftENST00000371588ENST00000367075DPM1chr20

49574900

-EZRchr6

159197536

-
Frame-shiftENST00000371588ENST00000367075DPM1chr20

49574899

-EZRchr6

159197536

-
Frame-shiftENST00000371588ENST00000392177DPM1chr20

49574900

-EZRchr6

159197536

-
Frame-shiftENST00000371588ENST00000392177DPM1chr20

49574899

-EZRchr6

159197536

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DPM1-EZR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for DPM1-EZR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:49574900/:159197536)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DPM1

O60762

EZR

P15311

FUNCTION: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.FUNCTION: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DPM1-EZR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DPM1-EZR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DPM1-EZR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DPM1-EZR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDPM1C1837396CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Ie5CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneDPM1C4317224Congenital disorder of glycosylation type 1q1GENOMICS_ENGLAND
TgeneC0033578Prostatic Neoplasms3CTD_human
TgeneC0376358Malignant neoplasm of prostate3CTD_human
TgeneC0007097Carcinoma1CTD_human
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC0024667Animal Mammary Neoplasms1CTD_human
TgeneC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneC0027627Neoplasm Metastasis1CTD_human
TgeneC0029408Degenerative polyarthritis1CTD_human
TgeneC0086743Osteoarthrosis Deformans1CTD_human
TgeneC0205696Anaplastic carcinoma1CTD_human
TgeneC0205697Carcinoma, Spindle-Cell1CTD_human
TgeneC0205698Undifferentiated carcinoma1CTD_human
TgeneC0205699Carcinomatosis1CTD_human
TgeneC1257925Mammary Carcinoma, Animal1CTD_human