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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IFT20-GLS (FusionGDB2 ID:HG90410TG2744)

Fusion Gene Summary for IFT20-GLS

check button Fusion gene summary
Fusion gene informationFusion gene name: IFT20-GLS
Fusion gene ID: hg90410tg2744
HgeneTgene
Gene symbol

IFT20

GLS

Gene ID

90410

2744

Gene nameintraflagellar transport 20glutaminase
Synonyms-AAD20|CASGID|EIEE71|GAC|GAM|GDPAG|GLS1|KGA
Cytomap('IFT20')('GLS')

17q11.2

2q32.2

Type of geneprotein-codingprotein-coding
Descriptionintraflagellar transport protein 20 homologintraflagellar transport 20 homologintraflagellar transport protein IFT20glutaminase kidney isoform, mitochondrialK-glutaminaseL-glutamine amidohydrolaseglutaminase Cglutaminase, phosphate-activated
Modification date2020032720200313
UniProtAcc

Q8IY31

.
Ensembl transtripts involved in fusion geneENST00000357896, ENST00000395418, 
ENST00000578122, ENST00000578985, 
ENST00000579419, ENST00000585089, 
ENST00000585313, 
Fusion gene scores* DoF score3 X 3 X 3=2712 X 9 X 5=540
# samples 312
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IFT20 [Title/Abstract] AND GLS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIFT20(26658882)-GLS(191827556), # samples:1
Anticipated loss of major functional domain due to fusion event.IFT20-GLS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IFT20-GLS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IFT20-GLS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
IFT20-GLS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
IFT20-GLS seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
IFT20-GLS seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
IFT20-GLS seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGLS

GO:0006537

glutamate biosynthetic process

16899818|22049910

TgeneGLS

GO:0006543

glutamine catabolic process

22049910

TgeneGLS

GO:0051289

protein homotetramerization

22049910


check buttonFusion gene breakpoints across IFT20 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across GLS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADC316034IFT20chr17

26658882

-GLSchr2

191827556

+


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Fusion Gene ORF analysis for IFT20-GLS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000357896ENST00000338435IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000357896ENST00000409215IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000357896ENST00000409428IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000357896ENST00000409626IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000357896ENST00000471443IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000395418ENST00000338435IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000395418ENST00000409215IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000395418ENST00000409428IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000395418ENST00000409626IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000395418ENST00000471443IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000578122ENST00000338435IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000578122ENST00000409215IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000578122ENST00000409428IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000578122ENST00000409626IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000578122ENST00000471443IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000578985ENST00000338435IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000578985ENST00000409215IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000578985ENST00000409428IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000578985ENST00000409626IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000578985ENST00000471443IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000579419ENST00000338435IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000579419ENST00000409215IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000579419ENST00000409428IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000579419ENST00000409626IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000579419ENST00000471443IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000585089ENST00000338435IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000585089ENST00000409215IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000585089ENST00000409428IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000585089ENST00000409626IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000585089ENST00000471443IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000585313ENST00000338435IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000585313ENST00000409215IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000585313ENST00000409428IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000585313ENST00000409626IFT20chr17

26658882

-GLSchr2

191827556

+
5CDS-intronENST00000585313ENST00000471443IFT20chr17

26658882

-GLSchr2

191827556

+
Frame-shiftENST00000357896ENST00000320717IFT20chr17

26658882

-GLSchr2

191827556

+
Frame-shiftENST00000395418ENST00000320717IFT20chr17

26658882

-GLSchr2

191827556

+
Frame-shiftENST00000579419ENST00000320717IFT20chr17

26658882

-GLSchr2

191827556

+
Frame-shiftENST00000585313ENST00000320717IFT20chr17

26658882

-GLSchr2

191827556

+
In-frameENST00000578122ENST00000320717IFT20chr17

26658882

-GLSchr2

191827556

+
In-frameENST00000578985ENST00000320717IFT20chr17

26658882

-GLSchr2

191827556

+
In-frameENST00000585089ENST00000320717IFT20chr17

26658882

-GLSchr2

191827556

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000585089IFT20chr1726658882-ENST00000320717GLSchr2191827556+3199476256672138
ENST00000578122IFT20chr1726658882-ENST00000320717GLSchr2191827556+3185462242658138
ENST00000578985IFT20chr1726658882-ENST00000320717GLSchr2191827556+3190467247663138

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000585089ENST00000320717IFT20chr1726658882-GLSchr2191827556+0.0176801870.9823198
ENST00000578122ENST00000320717IFT20chr1726658882-GLSchr2191827556+0.0178222430.98217773
ENST00000578985ENST00000320717IFT20chr1726658882-GLSchr2191827556+0.0178331160.9821669

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Fusion Genomic Features for IFT20-GLS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
IFT20chr1726658884-GLSchr2191827555+0.0001212660.99987876
IFT20chr1726658884-GLSchr2191827555+0.0001212660.99987876

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for IFT20-GLS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:26658882/chr2:191827556)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IFT20

Q8IY31

.
FUNCTION: Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium (PubMed:16775004). Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Required for protein stability of E3 ubiquitin ligases CBL and CBLB that mediate ubiquitination and internalization of PDGFRA for proper feedback inhibition of PDGFRA signaling (PubMed:29237719). Essential for male fertility. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella. May play a role in the transport of flagellar proteins ODF2 and SPAG16 to build sperm flagella and in the removal of redundant sperm cytoplasm (By similarity). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment (By similarity). {ECO:0000250|UniProtKB:Q61025, ECO:0000269|PubMed:16775004, ECO:0000269|PubMed:29237719}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGLSchr17:26658882chr2:191827556ENST00000338435015315_3220599.0RegionHighly mobile activation loop
TgeneGLSchr17:26658882chr2:191827556ENST000003207171618619_648617670.0RepeatNote=ANK 2
TgeneGLSchr17:26658882chr2:191827556ENST00000338435015585_6140599.0RepeatNote=ANK 1
TgeneGLSchr17:26658882chr2:191827556ENST00000338435015619_6480599.0RepeatNote=ANK 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIFT20chr17:26658882chr2:191827556ENST00000357896-2674_11442149.0Coiled coilOntology_term=ECO:0000255
HgeneIFT20chr17:26658882chr2:191827556ENST00000395418-2574_11442133.0Coiled coilOntology_term=ECO:0000255
HgeneIFT20chr17:26658882chr2:191827556ENST00000579419-3674_11442115.0Coiled coilOntology_term=ECO:0000255
HgeneIFT20chr17:26658882chr2:191827556ENST00000585089-3674_11468159.0Coiled coilOntology_term=ECO:0000255
HgeneIFT20chr17:26658882chr2:191827556ENST00000585313-3674_11442133.0Coiled coilOntology_term=ECO:0000255
HgeneIFT20chr17:26658882chr2:191827556ENST00000357896-2670_13242149.0RegionIFT57-binding
HgeneIFT20chr17:26658882chr2:191827556ENST00000395418-2570_13242133.0RegionIFT57-binding
HgeneIFT20chr17:26658882chr2:191827556ENST00000579419-3670_13242115.0RegionIFT57-binding
HgeneIFT20chr17:26658882chr2:191827556ENST00000585089-3670_13268159.0RegionIFT57-binding
HgeneIFT20chr17:26658882chr2:191827556ENST00000585313-3670_13242133.0RegionIFT57-binding
TgeneGLSchr17:26658882chr2:191827556ENST000003207171618315_322617670.0RegionHighly mobile activation loop
TgeneGLSchr17:26658882chr2:191827556ENST000003207171618585_614617670.0RepeatNote=ANK 1


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Fusion Gene Sequence for IFT20-GLS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>38416_38416_1_IFT20-GLS_IFT20_chr17_26658882_ENST00000578122_GLS_chr2_191827556_ENST00000320717_length(transcript)=3185nt_BP=462nt
GGCAGGCTGGCTGGGTACCGGCTGTCGCTGACCCAGGAGAAGCTGCCTGTCTACATCAGCCTGGGCTGCAGCGCGCTGCCGCCGCGGGGC
CGGCAGCTGAACTATGTGCTCTTCAGGGCGGGCACCGTGTTGCATTCATCTTTGTACCCCCAGCATCTAGCAGTGTTGGCATGTAGTAGG
CACTCAAGAAATGTGTGTTGAATGAACGATGCCTGTGACAAGCAAGCGGACTTTATTCTTTCCTGACCCTTGCTCCTATGACACACCTCC
TCCTGACTGCCACTGTCACTCCTTCAGAGCAGAACTCCTCTAGGGAACCTGGATGGGAAACAGCCATGGCCAAGGACATCCTGGGTGAAG
CAGGGCTACACTTTGATGAACTGAACAAGCTGAGGGTGTTGGACCCAGAGGTTACCCAGCAGACCATAGAGCTGAAGGAAGAGTGCAAAG
ACTTTGTGGACAGTGGAATAACACTCCCATGGATGAAGCACTGCACTTTGGACACCATGATGTATTTAAAATTCTCCAAGAATACCAAGT
CCAGTACACACCTCAAGGAGATTCTGACAACGGGAAGGAAAATCAAACCGTCCATAAGAATCTTGATGGATTGTTGTAATGGTCTCAAAT
CCCAAGATTTAAATCACTTACCTATTTAATTGTGGAAAATGATTATGAAGAACATGTGTATTTCTATCTGGTAGTGATGTATATTTTACA
TTTGTCATTTCAGTGTTACTGGAGTTTTCTTCATTGTGCACACAGGACAAATCTGATCTCTTTGGGAAAAAATAGAAATAAAACAATCTC
CCTCCATAATGTGAGCAATATTACCTCGTGCATTGTATAATTTGATGTAAAAGAAATAGTTACCAATGCTAGCTTGTGTGGTCTTCCATG
ATTTATTTGTGTTTTGTGAATTTTCAATTTATGGTGATGATCTGCTGATATGCATTTATAAAGTAAGCTCTGTTGTACAGTCTGTCCAAA
TGGGTCAAGGTTGCCTTTAGAAGCAAATAGTGTGATTTTCAAGACTTCAAATACAAATTTAGTTTAAGTGTTTGAACAACTATATGCACT
TACGGTTGTGTGTTTAAAATGTCTCTCTCACCCCCTAGCTTCATGATGTGACTCTTAAAAAACTATAATAGTTAACAACTGTTAGTAAGA
TAGACCAATTCTGATTAGACTTTATCAGGGAATCTGTTTAAGATATGTTTGGTGACCAAAACGTATGTGTGAATGTAGTTATAATGCTTT
TGAAAAATTTTCCTTTTTCTATATCCCCTTAGTCCAGCCTCTCTTCTCAGACATTTAGCTATCTGCCTCTTTCCTTTAGCTGGGAAAGTG
AGAGCTGGCATACTATGCAGTTTTTATGTTTTCCATAGTAAGTCAGAAAATGCCTCCTATTTCTGGCATCAGAACTTTGCCATTTGTCTA
CAGAAGACGAACCAGAGACAAAATTACTAAGTATAAATTAGTCAAGTTTATCAGTCTAAAAAACGAAGGGATGTGCAACTGCAGCTCTTT
AAGAAGTTTTTTTTTTTTAGCTTCTAGGGTAAAGATAAATTCAGAAATGCTCTAAGCTACCAAAGTTATTCTGAAAGTATGGGAACTGCT
ACAACTAACAAACATTTGTTTCCAAGCCTGTCATTAAGAGTCTGCATCAAGAGATTTGTCCTCCTTGGGGGACCACTGGATCATTCCAGA
TTTCTTGTGATTTTTCTATTGTGTAATTCTTGGTGGGCTCTGTAGTTTAATAATAAGAAAAAGGCCATTTCATTTTAAATTGTGACCTAT
AATTCTTTGTCTTGGGTTGGTAATTCAGGATTCATTTGGAAAGTGGGTAAAAGGGGCTTCAAAAAACGGATAGAACAGGATTTTCTAGGA
GTTACACATACATTTTATCCTGTCATACCTCGAGATAAAGTGGCATGTTAGTGAGGAGTTCTGATATTAAGCACACACACACATGCACAC
AAATGGACTTCTCTGAAGCTGTGTTTAGTGAAATGAGCTCAAGTACATGAATGTTAGTTGTTATCACATACAGCAAATTCCTTTTTTTTT
CTTTTTCTATGAGCACACTCTGCTGCTTCTAAACTTTACATGCCTGATGGCACCTTACTCCAGCAGCCTCCAGGTGCTTTCATTTTCACT
TCCAGTCTAAGCCAGTGGCTCCTGCCACTGCCCTCCCATTACCTAGATGGCACCTCCTTTGGTGAAACCACGGCCAATGTTCCTTAGCTG
CACCAGGCCCGAAGCTGTTCCCATGCTTGAGCTTCCATGGGGAGGATGCTGAGTGAGCAGTTTCCTACCCCGTGGATCTAGCAAGCCATG
GAGACAGGTAGCATTTGTAAGATGCTGCACAGGAGCAGCATTATCCCCAAAGATATTACAGGGTAGACACGTTTTAACTGAAATCAATCA
AGATAACTTTATTCAAAGAGCAGCCCGCTTTGTGTGACTAAAATGAAACAAGACAGTTGAATTGTGTGACTTGAAGATTACCAATGATTT
TGAGGCTTTTCTATAATAAAAAGAGGTTCTAACCATTATTTGGGAACAAAGAGAGTTTTCATCTTTTTTCAGATCAAAACCATTCTGTAA
AATCTTTGTTGTTTAATTAAATGTGCCGTTATTTACCCCTGATGTTATTTATGACTATGTGCCGATTCCTGCTCGGGCTGTTTGCTGTTG
GCTGGTAATAATATATTTGATTTAAATGCTGTTGACTGTGCTATTAACTGCTGCCGTCAGTAAACTCCAAAGATCTTTTTGTTTTGGCTT
TAGTATCATATGTGCTTTTTCTGTATCCTGAGCGCTCTATATGATCATGTTAATTTAAAGCTTTATACACATTGTTGTTTTTGCTGGTCT
CATCTTTGGTAATATGCTATACCCCACTGCTGCCCGACACTGCCCTTTAGCTGCAGAGCTGGATTAGCTGTTGACCATTTGATGCTGTTG
TCTGTCTGGCAGGGACTGAATGACCTGATGTCAGATTTAGATTCTTCCTGGGGATTACACAGCTATGAATGTATTTGCTTCTAAAACCTC
CCAAAGTGAATCTAATCTTAAAACTACAAGTTGTAAGTATTCTGAAATTGGGAAACATTTATTTTAAATGCAATCAGGTAGTGTTGCTTT

>38416_38416_1_IFT20-GLS_IFT20_chr17_26658882_ENST00000578122_GLS_chr2_191827556_ENST00000320717_length(amino acids)=138AA_BP=74
MTLAPMTHLLLTATVTPSEQNSSREPGWETAMAKDILGEAGLHFDELNKLRVLDPEVTQQTIELKEECKDFVDSGITLPWMKHCTLDTMM

--------------------------------------------------------------
>38416_38416_2_IFT20-GLS_IFT20_chr17_26658882_ENST00000578985_GLS_chr2_191827556_ENST00000320717_length(transcript)=3190nt_BP=467nt
GCCGTGGCAGGCTGGCTGGGTACCGGCTGTCGCTGACCCAGGAGAAGCTGCCTGTCTACATCAGCCTGGGCTGCAGCGCGCTGCCGCCGC
GGGGCCGGCAGCTGAACTATGTGCTCTTCAGGGCGGGCACCGTGTTGCATTCATCTTTGTACCCCCAGCATCTAGCAGTGTTGGCATGTA
GTAGGCACTCAAGAAATGTGTGTTGAATGAACGATGCCTGTGACAAGCAAGCGGACTTTATTCTTTCCTGACCCTTGCTCCTATGACACA
CCTCCTCCTGACTGCCACTGTCACTCCTTCAGAGCAGAACTCCTCTAGGGAACCTGGATGGGAAACAGCCATGGCCAAGGACATCCTGGG
TGAAGCAGGGCTACACTTTGATGAACTGAACAAGCTGAGGGTGTTGGACCCAGAGGTTACCCAGCAGACCATAGAGCTGAAGGAAGAGTG
CAAAGACTTTGTGGACAGTGGAATAACACTCCCATGGATGAAGCACTGCACTTTGGACACCATGATGTATTTAAAATTCTCCAAGAATAC
CAAGTCCAGTACACACCTCAAGGAGATTCTGACAACGGGAAGGAAAATCAAACCGTCCATAAGAATCTTGATGGATTGTTGTAATGGTCT
CAAATCCCAAGATTTAAATCACTTACCTATTTAATTGTGGAAAATGATTATGAAGAACATGTGTATTTCTATCTGGTAGTGATGTATATT
TTACATTTGTCATTTCAGTGTTACTGGAGTTTTCTTCATTGTGCACACAGGACAAATCTGATCTCTTTGGGAAAAAATAGAAATAAAACA
ATCTCCCTCCATAATGTGAGCAATATTACCTCGTGCATTGTATAATTTGATGTAAAAGAAATAGTTACCAATGCTAGCTTGTGTGGTCTT
CCATGATTTATTTGTGTTTTGTGAATTTTCAATTTATGGTGATGATCTGCTGATATGCATTTATAAAGTAAGCTCTGTTGTACAGTCTGT
CCAAATGGGTCAAGGTTGCCTTTAGAAGCAAATAGTGTGATTTTCAAGACTTCAAATACAAATTTAGTTTAAGTGTTTGAACAACTATAT
GCACTTACGGTTGTGTGTTTAAAATGTCTCTCTCACCCCCTAGCTTCATGATGTGACTCTTAAAAAACTATAATAGTTAACAACTGTTAG
TAAGATAGACCAATTCTGATTAGACTTTATCAGGGAATCTGTTTAAGATATGTTTGGTGACCAAAACGTATGTGTGAATGTAGTTATAAT
GCTTTTGAAAAATTTTCCTTTTTCTATATCCCCTTAGTCCAGCCTCTCTTCTCAGACATTTAGCTATCTGCCTCTTTCCTTTAGCTGGGA
AAGTGAGAGCTGGCATACTATGCAGTTTTTATGTTTTCCATAGTAAGTCAGAAAATGCCTCCTATTTCTGGCATCAGAACTTTGCCATTT
GTCTACAGAAGACGAACCAGAGACAAAATTACTAAGTATAAATTAGTCAAGTTTATCAGTCTAAAAAACGAAGGGATGTGCAACTGCAGC
TCTTTAAGAAGTTTTTTTTTTTTAGCTTCTAGGGTAAAGATAAATTCAGAAATGCTCTAAGCTACCAAAGTTATTCTGAAAGTATGGGAA
CTGCTACAACTAACAAACATTTGTTTCCAAGCCTGTCATTAAGAGTCTGCATCAAGAGATTTGTCCTCCTTGGGGGACCACTGGATCATT
CCAGATTTCTTGTGATTTTTCTATTGTGTAATTCTTGGTGGGCTCTGTAGTTTAATAATAAGAAAAAGGCCATTTCATTTTAAATTGTGA
CCTATAATTCTTTGTCTTGGGTTGGTAATTCAGGATTCATTTGGAAAGTGGGTAAAAGGGGCTTCAAAAAACGGATAGAACAGGATTTTC
TAGGAGTTACACATACATTTTATCCTGTCATACCTCGAGATAAAGTGGCATGTTAGTGAGGAGTTCTGATATTAAGCACACACACACATG
CACACAAATGGACTTCTCTGAAGCTGTGTTTAGTGAAATGAGCTCAAGTACATGAATGTTAGTTGTTATCACATACAGCAAATTCCTTTT
TTTTTCTTTTTCTATGAGCACACTCTGCTGCTTCTAAACTTTACATGCCTGATGGCACCTTACTCCAGCAGCCTCCAGGTGCTTTCATTT
TCACTTCCAGTCTAAGCCAGTGGCTCCTGCCACTGCCCTCCCATTACCTAGATGGCACCTCCTTTGGTGAAACCACGGCCAATGTTCCTT
AGCTGCACCAGGCCCGAAGCTGTTCCCATGCTTGAGCTTCCATGGGGAGGATGCTGAGTGAGCAGTTTCCTACCCCGTGGATCTAGCAAG
CCATGGAGACAGGTAGCATTTGTAAGATGCTGCACAGGAGCAGCATTATCCCCAAAGATATTACAGGGTAGACACGTTTTAACTGAAATC
AATCAAGATAACTTTATTCAAAGAGCAGCCCGCTTTGTGTGACTAAAATGAAACAAGACAGTTGAATTGTGTGACTTGAAGATTACCAAT
GATTTTGAGGCTTTTCTATAATAAAAAGAGGTTCTAACCATTATTTGGGAACAAAGAGAGTTTTCATCTTTTTTCAGATCAAAACCATTC
TGTAAAATCTTTGTTGTTTAATTAAATGTGCCGTTATTTACCCCTGATGTTATTTATGACTATGTGCCGATTCCTGCTCGGGCTGTTTGC
TGTTGGCTGGTAATAATATATTTGATTTAAATGCTGTTGACTGTGCTATTAACTGCTGCCGTCAGTAAACTCCAAAGATCTTTTTGTTTT
GGCTTTAGTATCATATGTGCTTTTTCTGTATCCTGAGCGCTCTATATGATCATGTTAATTTAAAGCTTTATACACATTGTTGTTTTTGCT
GGTCTCATCTTTGGTAATATGCTATACCCCACTGCTGCCCGACACTGCCCTTTAGCTGCAGAGCTGGATTAGCTGTTGACCATTTGATGC
TGTTGTCTGTCTGGCAGGGACTGAATGACCTGATGTCAGATTTAGATTCTTCCTGGGGATTACACAGCTATGAATGTATTTGCTTCTAAA
ACCTCCCAAAGTGAATCTAATCTTAAAACTACAAGTTGTAAGTATTCTGAAATTGGGAAACATTTATTTTAAATGCAATCAGGTAGTGTT

>38416_38416_2_IFT20-GLS_IFT20_chr17_26658882_ENST00000578985_GLS_chr2_191827556_ENST00000320717_length(amino acids)=138AA_BP=74
MTLAPMTHLLLTATVTPSEQNSSREPGWETAMAKDILGEAGLHFDELNKLRVLDPEVTQQTIELKEECKDFVDSGITLPWMKHCTLDTMM

--------------------------------------------------------------
>38416_38416_3_IFT20-GLS_IFT20_chr17_26658882_ENST00000585089_GLS_chr2_191827556_ENST00000320717_length(transcript)=3199nt_BP=476nt
GTGGCAGCGGCCGTGGCAGGCTGGCTGGGTACCGGCTGTCGCTGACCCAGGAGAAGCTGCCTGTCTACATCAGCCTGGGCTGCAGCGCGC
TGCCGCCGCGGGGCCGGCAGCTGAACTATGTGCTCTTCAGGGCGGGCACCGTGTTGCATTCATCTTTGTACCCCCAGCATCTAGCAGTGT
TGGCATGTAGTAGGCACTCAAGAAATGTGTGTTGAATGAACGATGCCTGTGACAAGCAAGCGGACTTTATTCTTTCCTGACCCTTGCTCC
TATGACACACCTCCTCCTGACTGCCACTGTCACTCCTTCAGAGCAGAACTCCTCTAGGGAACCTGGATGGGAAACAGCCATGGCCAAGGA
CATCCTGGGTGAAGCAGGGCTACACTTTGATGAACTGAACAAGCTGAGGGTGTTGGACCCAGAGGTTACCCAGCAGACCATAGAGCTGAA
GGAAGAGTGCAAAGACTTTGTGGACAGTGGAATAACACTCCCATGGATGAAGCACTGCACTTTGGACACCATGATGTATTTAAAATTCTC
CAAGAATACCAAGTCCAGTACACACCTCAAGGAGATTCTGACAACGGGAAGGAAAATCAAACCGTCCATAAGAATCTTGATGGATTGTTG
TAATGGTCTCAAATCCCAAGATTTAAATCACTTACCTATTTAATTGTGGAAAATGATTATGAAGAACATGTGTATTTCTATCTGGTAGTG
ATGTATATTTTACATTTGTCATTTCAGTGTTACTGGAGTTTTCTTCATTGTGCACACAGGACAAATCTGATCTCTTTGGGAAAAAATAGA
AATAAAACAATCTCCCTCCATAATGTGAGCAATATTACCTCGTGCATTGTATAATTTGATGTAAAAGAAATAGTTACCAATGCTAGCTTG
TGTGGTCTTCCATGATTTATTTGTGTTTTGTGAATTTTCAATTTATGGTGATGATCTGCTGATATGCATTTATAAAGTAAGCTCTGTTGT
ACAGTCTGTCCAAATGGGTCAAGGTTGCCTTTAGAAGCAAATAGTGTGATTTTCAAGACTTCAAATACAAATTTAGTTTAAGTGTTTGAA
CAACTATATGCACTTACGGTTGTGTGTTTAAAATGTCTCTCTCACCCCCTAGCTTCATGATGTGACTCTTAAAAAACTATAATAGTTAAC
AACTGTTAGTAAGATAGACCAATTCTGATTAGACTTTATCAGGGAATCTGTTTAAGATATGTTTGGTGACCAAAACGTATGTGTGAATGT
AGTTATAATGCTTTTGAAAAATTTTCCTTTTTCTATATCCCCTTAGTCCAGCCTCTCTTCTCAGACATTTAGCTATCTGCCTCTTTCCTT
TAGCTGGGAAAGTGAGAGCTGGCATACTATGCAGTTTTTATGTTTTCCATAGTAAGTCAGAAAATGCCTCCTATTTCTGGCATCAGAACT
TTGCCATTTGTCTACAGAAGACGAACCAGAGACAAAATTACTAAGTATAAATTAGTCAAGTTTATCAGTCTAAAAAACGAAGGGATGTGC
AACTGCAGCTCTTTAAGAAGTTTTTTTTTTTTAGCTTCTAGGGTAAAGATAAATTCAGAAATGCTCTAAGCTACCAAAGTTATTCTGAAA
GTATGGGAACTGCTACAACTAACAAACATTTGTTTCCAAGCCTGTCATTAAGAGTCTGCATCAAGAGATTTGTCCTCCTTGGGGGACCAC
TGGATCATTCCAGATTTCTTGTGATTTTTCTATTGTGTAATTCTTGGTGGGCTCTGTAGTTTAATAATAAGAAAAAGGCCATTTCATTTT
AAATTGTGACCTATAATTCTTTGTCTTGGGTTGGTAATTCAGGATTCATTTGGAAAGTGGGTAAAAGGGGCTTCAAAAAACGGATAGAAC
AGGATTTTCTAGGAGTTACACATACATTTTATCCTGTCATACCTCGAGATAAAGTGGCATGTTAGTGAGGAGTTCTGATATTAAGCACAC
ACACACATGCACACAAATGGACTTCTCTGAAGCTGTGTTTAGTGAAATGAGCTCAAGTACATGAATGTTAGTTGTTATCACATACAGCAA
ATTCCTTTTTTTTTCTTTTTCTATGAGCACACTCTGCTGCTTCTAAACTTTACATGCCTGATGGCACCTTACTCCAGCAGCCTCCAGGTG
CTTTCATTTTCACTTCCAGTCTAAGCCAGTGGCTCCTGCCACTGCCCTCCCATTACCTAGATGGCACCTCCTTTGGTGAAACCACGGCCA
ATGTTCCTTAGCTGCACCAGGCCCGAAGCTGTTCCCATGCTTGAGCTTCCATGGGGAGGATGCTGAGTGAGCAGTTTCCTACCCCGTGGA
TCTAGCAAGCCATGGAGACAGGTAGCATTTGTAAGATGCTGCACAGGAGCAGCATTATCCCCAAAGATATTACAGGGTAGACACGTTTTA
ACTGAAATCAATCAAGATAACTTTATTCAAAGAGCAGCCCGCTTTGTGTGACTAAAATGAAACAAGACAGTTGAATTGTGTGACTTGAAG
ATTACCAATGATTTTGAGGCTTTTCTATAATAAAAAGAGGTTCTAACCATTATTTGGGAACAAAGAGAGTTTTCATCTTTTTTCAGATCA
AAACCATTCTGTAAAATCTTTGTTGTTTAATTAAATGTGCCGTTATTTACCCCTGATGTTATTTATGACTATGTGCCGATTCCTGCTCGG
GCTGTTTGCTGTTGGCTGGTAATAATATATTTGATTTAAATGCTGTTGACTGTGCTATTAACTGCTGCCGTCAGTAAACTCCAAAGATCT
TTTTGTTTTGGCTTTAGTATCATATGTGCTTTTTCTGTATCCTGAGCGCTCTATATGATCATGTTAATTTAAAGCTTTATACACATTGTT
GTTTTTGCTGGTCTCATCTTTGGTAATATGCTATACCCCACTGCTGCCCGACACTGCCCTTTAGCTGCAGAGCTGGATTAGCTGTTGACC
ATTTGATGCTGTTGTCTGTCTGGCAGGGACTGAATGACCTGATGTCAGATTTAGATTCTTCCTGGGGATTACACAGCTATGAATGTATTT
GCTTCTAAAACCTCCCAAAGTGAATCTAATCTTAAAACTACAAGTTGTAAGTATTCTGAAATTGGGAAACATTTATTTTAAATGCAATCA

>38416_38416_3_IFT20-GLS_IFT20_chr17_26658882_ENST00000585089_GLS_chr2_191827556_ENST00000320717_length(amino acids)=138AA_BP=74
MTLAPMTHLLLTATVTPSEQNSSREPGWETAMAKDILGEAGLHFDELNKLRVLDPEVTQQTIELKEECKDFVDSGITLPWMKHCTLDTMM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for IFT20-GLS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IFT20-GLS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IFT20-GLS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0000786Spontaneous abortion1CTD_human
TgeneC0000822Abortion, Tubal1CTD_human
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC0029408Degenerative polyarthritis1CTD_human
TgeneC0086743Osteoarthrosis Deformans1CTD_human
TgeneC3830362Early Pregnancy Loss1CTD_human
TgeneC4552766Miscarriage1CTD_human