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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:ACVR2A-AKT3 (FusionGDB2 ID:HG92TG10000)

Fusion Gene Summary for ACVR2A-AKT3

check button Fusion gene summary
Fusion gene informationFusion gene name: ACVR2A-AKT3
Fusion gene ID: hg92tg10000
HgeneTgene
Gene symbol

ACVR2A

AKT3

Gene ID

92

10000

Gene nameactivin A receptor type 2AAKT serine/threonine kinase 3
SynonymsACTRII|ACVR2MPPH|MPPH2|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2
Cytomap('ACVR2A')('AKT3')

2q22.3-q23.1

1q43-q44

Type of geneprotein-codingprotein-coding
Descriptionactivin receptor type-2Aactivin A receptor, type IIARAC-gamma serine/threonine-protein kinasePKB gammaRAC-gamma serine/threonine protein kinasev-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000241416, ENST00000404590, 
ENST00000495775, ENST00000535787, 
Fusion gene scores* DoF score8 X 7 X 7=39219 X 18 X 8=2736
# samples 1019
** MAII scorelog2(10/392*10)=-1.97085365434048
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/2736*10)=-3.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACVR2A [Title/Abstract] AND AKT3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACVR2A(148602776)-AKT3(243828185), # samples:3
Anticipated loss of major functional domain due to fusion event.ACVR2A-AKT3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACVR2A-AKT3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACVR2A-AKT3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACVR2A-AKT3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACVR2A

GO:0030509

BMP signaling pathway

18436533

HgeneACVR2A

GO:0032927

positive regulation of activin receptor signaling pathway

12665502

HgeneACVR2A

GO:0045648

positive regulation of erythrocyte differentiation

9032295

TgeneAKT3

GO:0043536

positive regulation of blood vessel endothelial cell migration

28254819

TgeneAKT3

GO:1905564

positive regulation of vascular endothelial cell proliferation

28254819


check buttonFusion gene breakpoints across ACVR2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across AKT3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-G9-6348-01AACVR2Achr2

148602776

-AKT3chr1

243828185

-
ChimerDB4PRADTCGA-G9-6348-01AACVR2Achr2

148602776

+AKT3chr1

243828185

-
ChimerDB4PRADTCGA-G9-6348ACVR2Achr2

148602776

+AKT3chr1

243828185

-


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Fusion Gene ORF analysis for ACVR2A-AKT3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000241416ENST00000492957ACVR2Achr2

148602776

+AKT3chr1

243828185

-
5CDS-intronENST00000404590ENST00000492957ACVR2Achr2

148602776

+AKT3chr1

243828185

-
In-frameENST00000241416ENST00000263826ACVR2Achr2

148602776

+AKT3chr1

243828185

-
In-frameENST00000241416ENST00000336199ACVR2Achr2

148602776

+AKT3chr1

243828185

-
In-frameENST00000241416ENST00000366539ACVR2Achr2

148602776

+AKT3chr1

243828185

-
In-frameENST00000241416ENST00000366540ACVR2Achr2

148602776

+AKT3chr1

243828185

-
In-frameENST00000404590ENST00000263826ACVR2Achr2

148602776

+AKT3chr1

243828185

-
In-frameENST00000404590ENST00000336199ACVR2Achr2

148602776

+AKT3chr1

243828185

-
In-frameENST00000404590ENST00000366539ACVR2Achr2

148602776

+AKT3chr1

243828185

-
In-frameENST00000404590ENST00000366540ACVR2Achr2

148602776

+AKT3chr1

243828185

-
intron-3CDSENST00000495775ENST00000263826ACVR2Achr2

148602776

+AKT3chr1

243828185

-
intron-3CDSENST00000495775ENST00000336199ACVR2Achr2

148602776

+AKT3chr1

243828185

-
intron-3CDSENST00000495775ENST00000366539ACVR2Achr2

148602776

+AKT3chr1

243828185

-
intron-3CDSENST00000495775ENST00000366540ACVR2Achr2

148602776

+AKT3chr1

243828185

-
intron-3CDSENST00000535787ENST00000263826ACVR2Achr2

148602776

+AKT3chr1

243828185

-
intron-3CDSENST00000535787ENST00000336199ACVR2Achr2

148602776

+AKT3chr1

243828185

-
intron-3CDSENST00000535787ENST00000366539ACVR2Achr2

148602776

+AKT3chr1

243828185

-
intron-3CDSENST00000535787ENST00000366540ACVR2Achr2

148602776

+AKT3chr1

243828185

-
intron-intronENST00000495775ENST00000492957ACVR2Achr2

148602776

+AKT3chr1

243828185

-
intron-intronENST00000535787ENST00000492957ACVR2Achr2

148602776

+AKT3chr1

243828185

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000241416ACVR2Achr2148602776+ENST00000336199AKT3chr1243828185-21416916361916426
ENST00000241416ACVR2Achr2148602776+ENST00000366540AKT3chr1243828185-19416916361916426
ENST00000241416ACVR2Achr2148602776+ENST00000366539AKT3chr1243828185-54456916361958440
ENST00000241416ACVR2Achr2148602776+ENST00000263826AKT3chr1243828185-40266916361958440
ENST00000404590ACVR2Achr2148602776+ENST00000336199AKT3chr1243828185-16752251701450426
ENST00000404590ACVR2Achr2148602776+ENST00000366540AKT3chr1243828185-14752251701450426
ENST00000404590ACVR2Achr2148602776+ENST00000366539AKT3chr1243828185-49792251701492440
ENST00000404590ACVR2Achr2148602776+ENST00000263826AKT3chr1243828185-35602251701492440

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000241416ENST00000336199ACVR2Achr2148602776+AKT3chr1243828185-0.0001851230.9998149
ENST00000241416ENST00000366540ACVR2Achr2148602776+AKT3chr1243828185-0.0001586020.99984133
ENST00000241416ENST00000366539ACVR2Achr2148602776+AKT3chr1243828185-0.0001463140.9998536
ENST00000241416ENST00000263826ACVR2Achr2148602776+AKT3chr1243828185-0.0001772550.9998228
ENST00000404590ENST00000336199ACVR2Achr2148602776+AKT3chr1243828185-0.0003378050.99966216
ENST00000404590ENST00000366540ACVR2Achr2148602776+AKT3chr1243828185-0.0003220460.999678
ENST00000404590ENST00000366539ACVR2Achr2148602776+AKT3chr1243828185-0.0001983790.9998017
ENST00000404590ENST00000263826ACVR2Achr2148602776+AKT3chr1243828185-0.0002721050.9997279

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Fusion Genomic Features for ACVR2A-AKT3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ACVR2A-AKT3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:148602776/chr1:243828185)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAKT3chr2:148602776chr1:243828185ENST00000263826113148_40557480.0DomainProtein kinase
TgeneAKT3chr2:148602776chr1:243828185ENST00000263826113406_47957480.0DomainAGC-kinase C-terminal
TgeneAKT3chr2:148602776chr1:243828185ENST00000336199114148_40557476.0DomainProtein kinase
TgeneAKT3chr2:148602776chr1:243828185ENST00000336199114406_47957476.0DomainAGC-kinase C-terminal
TgeneAKT3chr2:148602776chr1:243828185ENST00000366539214148_40557480.0DomainProtein kinase
TgeneAKT3chr2:148602776chr1:243828185ENST00000366539214406_47957480.0DomainAGC-kinase C-terminal
TgeneAKT3chr2:148602776chr1:243828185ENST00000366540214148_40557466.0DomainProtein kinase
TgeneAKT3chr2:148602776chr1:243828185ENST00000366540214406_47957466.0DomainAGC-kinase C-terminal
TgeneAKT3chr2:148602776chr1:243828185ENST00000263826113154_16257480.0Nucleotide bindingATP
TgeneAKT3chr2:148602776chr1:243828185ENST00000336199114154_16257476.0Nucleotide bindingATP
TgeneAKT3chr2:148602776chr1:243828185ENST00000366539214154_16257480.0Nucleotide bindingATP
TgeneAKT3chr2:148602776chr1:243828185ENST00000366540214154_16257466.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACVR2Achr2:148602776chr1:243828185ENST00000241416+111192_48518514.0DomainProtein kinase
HgeneACVR2Achr2:148602776chr1:243828185ENST00000404590+212192_48518514.0DomainProtein kinase
HgeneACVR2Achr2:148602776chr1:243828185ENST00000241416+111198_20618514.0Nucleotide bindingATP
HgeneACVR2Achr2:148602776chr1:243828185ENST00000404590+212198_20618514.0Nucleotide bindingATP
HgeneACVR2Achr2:148602776chr1:243828185ENST00000241416+111162_51318514.0Topological domainCytoplasmic
HgeneACVR2Achr2:148602776chr1:243828185ENST00000241416+11120_13518514.0Topological domainExtracellular
HgeneACVR2Achr2:148602776chr1:243828185ENST00000404590+212162_51318514.0Topological domainCytoplasmic
HgeneACVR2Achr2:148602776chr1:243828185ENST00000404590+21220_13518514.0Topological domainExtracellular
HgeneACVR2Achr2:148602776chr1:243828185ENST00000241416+111136_16118514.0TransmembraneHelical
HgeneACVR2Achr2:148602776chr1:243828185ENST00000404590+212136_16118514.0TransmembraneHelical
TgeneAKT3chr2:148602776chr1:243828185ENST000002638261135_10757480.0DomainPH
TgeneAKT3chr2:148602776chr1:243828185ENST000003361991145_10757476.0DomainPH
TgeneAKT3chr2:148602776chr1:243828185ENST000003665392145_10757480.0DomainPH
TgeneAKT3chr2:148602776chr1:243828185ENST000003665402145_10757466.0DomainPH


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Fusion Gene Sequence for ACVR2A-AKT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1904_1904_1_ACVR2A-AKT3_ACVR2A_chr2_148602776_ENST00000241416_AKT3_chr1_243828185_ENST00000263826_length(transcript)=4026nt_BP=691nt
AGGAGACCGAAAACGCGGCCGAGCCCGGAGCCCGGAGCTGGAGCCAGAGCCTGGACCAGAACTTGGCCGCCGCCTGCACCGCCGCCGCCG
CTGCCGCCCGCCGCCCCTTCCCCGCGCCGCAGCCGCCTCGCCGCCACCGCCGCGAGCTCGGCCGCCAGTGGTCCTCGGACTTTAGGTGTC
TGGGTTGAAGGTCGGTCCGGACATCGGACCCAGTCAGTTCCCAGACTGTCCGGGCGGCAGCGGACGCCGCTGCCGCCGCCGCCTCTTCGT
CGCCTCAGCCTGGCGTTTTGTTCCGAGAGACGGGAGAGGCGAGCGGAGCTGACAGTGATTTTGACAGTGATTTAAACCCGCTTTTGTTGT
TGTTGGCTTTTCGTTGTTTGGTTTTGTGTGTTGTGCGTGTGTGTGGCGGTTTTTCCCCCGTGGTGCATTTTATTTTTTATCGTTGTGCTC
TTTTTTTTCTTTTTTTTTTTTAACCCAGTGAGCGTTTTTTTTTTTTTTTTTTTTTTTTTTTGGTCTGGGCTTCCGAATATGTTTTATGAC
GGTTGATTTTACACCAGGAGGTTTGTCTCCGAGGAAGACCCAGGGAACTGGATATCTAGCGAGAACTTCCTCCGGATTCCCCGGCGCCTC
GGGAAAATGGGAGCTGCTGCAAAGTTGGCGTTTGCCGTCTTTCTTATCTCCTGTTCTTCAGAATGCCAGTTAATGAAAACAGAACGACCA
AAGCCAAACACATTTATAATCAGATGTCTCCAGTGGACTACTGTTATAGAGAGAACATTTCATGTAGATACTCCAGAGGAAAGGGAAGAA
TGGACAGAAGCTATCCAGGCTGTAGCAGACAGACTGCAGAGGCAAGAAGAGGAGAGAATGAATTGTAGTCCAACTTCACAAATTGATAAT
ATAGGAGAGGAAGAGATGGATGCCTCTACAACCCATCATAAAAGAAAGACAATGAATGATTTTGACTATTTGAAACTACTAGGTAAAGGC
ACTTTTGGGAAAGTTATTTTGGTTCGAGAGAAGGCAAGTGGAAAATACTATGCTATGAAGATTCTGAAGAAAGAAGTCATTATTGCAAAG
GATGAAGTGGCACACACTCTAACTGAAAGCAGAGTATTAAAGAACACTAGACATCCCTTTTTAACATCCTTGAAATATTCCTTCCAGACA
AAAGACCGTTTGTGTTTTGTGATGGAATATGTTAATGGGGGCGAGCTGTTTTTCCATTTGTCGAGAGAGCGGGTGTTCTCTGAGGACCGC
ACACGTTTCTATGGTGCAGAAATTGTCTCTGCCTTGGACTATCTACATTCCGGAAAGATTGTGTACCGTGATCTCAAGTTGGAGAATCTA
ATGCTGGACAAAGATGGCCACATAAAAATTACAGATTTTGGACTTTGCAAAGAAGGGATCACAGATGCAGCCACCATGAAGACATTCTGT
GGCACTCCAGAATATCTGGCACCAGAGGTGTTAGAAGATAATGACTATGGCCGAGCAGTAGACTGGTGGGGCCTAGGGGTTGTCATGTAT
GAAATGATGTGTGGGAGGTTACCTTTCTACAACCAGGACCATGAGAAACTTTTTGAATTAATATTAATGGAAGACATTAAATTTCCTCGA
ACACTCTCTTCAGATGCAAAATCATTGCTTTCAGGGCTCTTGATAAAGGATCCAAATAAACGCCTTGGTGGAGGACCAGATGATGCAAAA
GAAATTATGAGACACAGTTTCTTCTCTGGAGTAAACTGGCAAGATGTATATGATAAAAAGCTTGTACCTCCTTTTAAACCTCAAGTAACA
TCTGAGACAGATACTAGATATTTTGATGAAGAATTTACAGCTCAGACTATTACAATAACACCACCTGAAAAATATGATGAGGATGGTATG
GACTGCATGGACAATGAGAGGCGGCCGCATTTCCCTCAATTTTCCTACTCTGCAAGTGGACGAGAATAAGTCTCTTTCATTCTGCTACTT
CACTGTCATCTTCAATTTATTACTGAAAATGATTCCTGGACATCACCAGTCCTAGCTCTTACACATAGCAGGGGCACCTTCCGACATCCC
AGACCAGCCAAGGGTCCTCACCCCTCGCCACCTTTCACCCTCATGAAAACACACATACACGCAAATACACTCCAGTTTTTGTTTTTGCAT
GAAATTGTATCTCAGTCTAAGGTCTCATGCTGTTGCTGCTACTGTCTTACTATTATAGCAACTTTAAGAAGTAATTTTCCAACCTTTGGA
AGTCATGAGCCCACCATTGTTCATTTGTGCACCAATTATCATCTTTTGATCTTTTAGTTTTTCCCTCAGTGAAGGCTAAATGAGATACAC
TGATTCTAGGTACATTTTTTAACTTTCTAGAAGAGAAAAACTAACTAGACTAAGAAGATTTAGTTTATAAATTCAGAACAAGCAATTGTG
GAAGGGTGGTGGCGTGCATATGTAAAGCACATCAGATCCGTGCGTGAAGTAGGCATATATCACTAAGCTGTGGCTGGAATTGATTAGGAA
GCATTTGGTAGAAGGACTGAACAACTGTTGGGATATATATATATATATATAATTTTTTTTTTTTAAATTCCTGGTGGATACTGTAGAAGA
AGCCCATATCACATGTGGATGTCGAGACTTCACGGGCAATCATGAGCAAGTGAACACTGTTCTACCAAGAACTGAAGGCATATGCACAGT
CAAGGTCACTTAAAGGGTCTTATGAAACAATTTGAGCCAGAGAGCATCTTTCCCCTGTGCTTGGAAACCTTTTTTCCTTCTTGACATTTA
TCACCTCTGATGGCTGAAGAATGTAGACAGGTATAATGATACTGCTTTTCACCAAAATTTCTACACCAAGGTAAACAGGTGTTTGCCTTA
TTTAATTTTTTACTTTCAGTTCTACGTGAATTAGCTTTTTCTCAGATGTTGAAACTTTGAATGTCCTTTTATGATTTTGTTTATATTGCA
GTAGTATTTATTTTTTAGTGATGAGAATTGTATGTCATGTTAGCAAACGCAGCTCCAACTTATATAAAATAGACTTACTGCAGTTACTTT
TGACCCATGTGCAAGGATTGTACACGCTGATGAGAATCATGCACTTTTTCTCCTCTGTTAAAAAAAATGATAAGGCTCTGAAATGGAATA
TATTGGTTAGAATTTGGCTTTGGGAGAAGAGATGCTGCCATTTAACCCCTTGGTACTGAAAATGAGAAAATCCCCAACTATGCATGCCAA
GGGGTTAATGAAACAAATAGCTGTTGACGTTTGCTCATTTAAGAATTTGAAACGTTATGATGACCTGGCAACAAAAAGTAATGAAGAAAA
TTGAGACCTGAGTGAAGATAAGAAATGATCTTTACGTGGCAAAATGAACACATCTTGAGTATTTAGGAAATGGGCAGTGAAGGCTAAGAA
CCTGGTGTGTTTCTTGGGATCATGGTACATTTATCACTGAATTAAGCCATCAGGGAAAAAACAACAAAAAAAGAGAACACCTCCAGCTTT
TCTTTTTCTGTATATACTCATGTCCCCCAGATTCCAACATTTCTCACTGAAAGGGGGCATGTATGCAAACCTCATCTTTCTCCTTCATTA
ATGATGATCTTCAGATTAAACCCTTTGGTGCTAGGAGCTGACAATTTCCAAAGCAGCCTGTGAAGTCCTAGGGGCTGGGGGCCACTCTTG
CGGCAAGCAGAAGGCCATCCTACTCCGCGGAGTGATCATGGAAATGTATTTTAGTTAAACTCTGACAGCTCCCAAACGGAAGACTACAGC
ATGACGTAGTATTATGATTGCATTGTATGAAAGAGCAAGTGACTTTCTAAGTAGGATGAATCATATTCATATGCAGATGTCTTAGCCTCT
TGACGCTGGAAGTGTGGATTTATAGCTATGAAACCACTGCTGGCAGTGGGTGGGCCACTGGGACTGACGGGGGTTAAAGGGCATTTTACT

>1904_1904_1_ACVR2A-AKT3_ACVR2A_chr2_148602776_ENST00000241416_AKT3_chr1_243828185_ENST00000263826_length(amino acids)=440AA_BP=18
MGAAAKLAFAVFLISCSSECQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIG
EEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKD
RLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGT
PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEI

--------------------------------------------------------------
>1904_1904_2_ACVR2A-AKT3_ACVR2A_chr2_148602776_ENST00000241416_AKT3_chr1_243828185_ENST00000336199_length(transcript)=2141nt_BP=691nt
AGGAGACCGAAAACGCGGCCGAGCCCGGAGCCCGGAGCTGGAGCCAGAGCCTGGACCAGAACTTGGCCGCCGCCTGCACCGCCGCCGCCG
CTGCCGCCCGCCGCCCCTTCCCCGCGCCGCAGCCGCCTCGCCGCCACCGCCGCGAGCTCGGCCGCCAGTGGTCCTCGGACTTTAGGTGTC
TGGGTTGAAGGTCGGTCCGGACATCGGACCCAGTCAGTTCCCAGACTGTCCGGGCGGCAGCGGACGCCGCTGCCGCCGCCGCCTCTTCGT
CGCCTCAGCCTGGCGTTTTGTTCCGAGAGACGGGAGAGGCGAGCGGAGCTGACAGTGATTTTGACAGTGATTTAAACCCGCTTTTGTTGT
TGTTGGCTTTTCGTTGTTTGGTTTTGTGTGTTGTGCGTGTGTGTGGCGGTTTTTCCCCCGTGGTGCATTTTATTTTTTATCGTTGTGCTC
TTTTTTTTCTTTTTTTTTTTTAACCCAGTGAGCGTTTTTTTTTTTTTTTTTTTTTTTTTTTGGTCTGGGCTTCCGAATATGTTTTATGAC
GGTTGATTTTACACCAGGAGGTTTGTCTCCGAGGAAGACCCAGGGAACTGGATATCTAGCGAGAACTTCCTCCGGATTCCCCGGCGCCTC
GGGAAAATGGGAGCTGCTGCAAAGTTGGCGTTTGCCGTCTTTCTTATCTCCTGTTCTTCAGAATGCCAGTTAATGAAAACAGAACGACCA
AAGCCAAACACATTTATAATCAGATGTCTCCAGTGGACTACTGTTATAGAGAGAACATTTCATGTAGATACTCCAGAGGAAAGGGAAGAA
TGGACAGAAGCTATCCAGGCTGTAGCAGACAGACTGCAGAGGCAAGAAGAGGAGAGAATGAATTGTAGTCCAACTTCACAAATTGATAAT
ATAGGAGAGGAAGAGATGGATGCCTCTACAACCCATCATAAAAGAAAGACAATGAATGATTTTGACTATTTGAAACTACTAGGTAAAGGC
ACTTTTGGGAAAGTTATTTTGGTTCGAGAGAAGGCAAGTGGAAAATACTATGCTATGAAGATTCTGAAGAAAGAAGTCATTATTGCAAAG
GATGAAGTGGCACACACTCTAACTGAAAGCAGAGTATTAAAGAACACTAGACATCCCTTTTTAACATCCTTGAAATATTCCTTCCAGACA
AAAGACCGTTTGTGTTTTGTGATGGAATATGTTAATGGGGGCGAGCTGTTTTTCCATTTGTCGAGAGAGCGGGTGTTCTCTGAGGACCGC
ACACGTTTCTATGGTGCAGAAATTGTCTCTGCCTTGGACTATCTACATTCCGGAAAGATTGTGTACCGTGATCTCAAGTTGGAGAATCTA
ATGCTGGACAAAGATGGCCACATAAAAATTACAGATTTTGGACTTTGCAAAGAAGGGATCACAGATGCAGCCACCATGAAGACATTCTGT
GGCACTCCAGAATATCTGGCACCAGAGGTGTTAGAAGATAATGACTATGGCCGAGCAGTAGACTGGTGGGGCCTAGGGGTTGTCATGTAT
GAAATGATGTGTGGGAGGTTACCTTTCTACAACCAGGACCATGAGAAACTTTTTGAATTAATATTAATGGAAGACATTAAATTTCCTCGA
ACACTCTCTTCAGATGCAAAATCATTGCTTTCAGGGCTCTTGATAAAGGATCCAAATAAACGCCTTGGTGGAGGACCAGATGATGCAAAA
GAAATTATGAGACACAGTTTCTTCTCTGGAGTAAACTGGCAAGATGTATATGATAAAAAGCTTGTACCTCCTTTTAAACCTCAAGTAACA
TCTGAGACAGATACTAGATATTTTGATGAAGAATTTACAGCTCAGACTATTACAATAACACCACCTGAAAAATGTCAGCAATCAGATTGT
GGCATGCTGGGTAACTGGAAAAAATAATAAAAATCGGCTTCCTACAGCCAGCAGCACAGTCACCCATGGAACTGTTGGCTTTGGATTAAA
TGTGGAATTGAACGACTACCCAGAAGTGTTCTGGAAAGAAGCGAGATGTGTGGCCTGCCTCACCGTCCTCACCCATCAAAAGCACCAGCA

>1904_1904_2_ACVR2A-AKT3_ACVR2A_chr2_148602776_ENST00000241416_AKT3_chr1_243828185_ENST00000336199_length(amino acids)=426AA_BP=18
MGAAAKLAFAVFLISCSSECQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIG
EEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKD
RLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGT
PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEI

--------------------------------------------------------------
>1904_1904_3_ACVR2A-AKT3_ACVR2A_chr2_148602776_ENST00000241416_AKT3_chr1_243828185_ENST00000366539_length(transcript)=5445nt_BP=691nt
AGGAGACCGAAAACGCGGCCGAGCCCGGAGCCCGGAGCTGGAGCCAGAGCCTGGACCAGAACTTGGCCGCCGCCTGCACCGCCGCCGCCG
CTGCCGCCCGCCGCCCCTTCCCCGCGCCGCAGCCGCCTCGCCGCCACCGCCGCGAGCTCGGCCGCCAGTGGTCCTCGGACTTTAGGTGTC
TGGGTTGAAGGTCGGTCCGGACATCGGACCCAGTCAGTTCCCAGACTGTCCGGGCGGCAGCGGACGCCGCTGCCGCCGCCGCCTCTTCGT
CGCCTCAGCCTGGCGTTTTGTTCCGAGAGACGGGAGAGGCGAGCGGAGCTGACAGTGATTTTGACAGTGATTTAAACCCGCTTTTGTTGT
TGTTGGCTTTTCGTTGTTTGGTTTTGTGTGTTGTGCGTGTGTGTGGCGGTTTTTCCCCCGTGGTGCATTTTATTTTTTATCGTTGTGCTC
TTTTTTTTCTTTTTTTTTTTTAACCCAGTGAGCGTTTTTTTTTTTTTTTTTTTTTTTTTTTGGTCTGGGCTTCCGAATATGTTTTATGAC
GGTTGATTTTACACCAGGAGGTTTGTCTCCGAGGAAGACCCAGGGAACTGGATATCTAGCGAGAACTTCCTCCGGATTCCCCGGCGCCTC
GGGAAAATGGGAGCTGCTGCAAAGTTGGCGTTTGCCGTCTTTCTTATCTCCTGTTCTTCAGAATGCCAGTTAATGAAAACAGAACGACCA
AAGCCAAACACATTTATAATCAGATGTCTCCAGTGGACTACTGTTATAGAGAGAACATTTCATGTAGATACTCCAGAGGAAAGGGAAGAA
TGGACAGAAGCTATCCAGGCTGTAGCAGACAGACTGCAGAGGCAAGAAGAGGAGAGAATGAATTGTAGTCCAACTTCACAAATTGATAAT
ATAGGAGAGGAAGAGATGGATGCCTCTACAACCCATCATAAAAGAAAGACAATGAATGATTTTGACTATTTGAAACTACTAGGTAAAGGC
ACTTTTGGGAAAGTTATTTTGGTTCGAGAGAAGGCAAGTGGAAAATACTATGCTATGAAGATTCTGAAGAAAGAAGTCATTATTGCAAAG
GATGAAGTGGCACACACTCTAACTGAAAGCAGAGTATTAAAGAACACTAGACATCCCTTTTTAACATCCTTGAAATATTCCTTCCAGACA
AAAGACCGTTTGTGTTTTGTGATGGAATATGTTAATGGGGGCGAGCTGTTTTTCCATTTGTCGAGAGAGCGGGTGTTCTCTGAGGACCGC
ACACGTTTCTATGGTGCAGAAATTGTCTCTGCCTTGGACTATCTACATTCCGGAAAGATTGTGTACCGTGATCTCAAGTTGGAGAATCTA
ATGCTGGACAAAGATGGCCACATAAAAATTACAGATTTTGGACTTTGCAAAGAAGGGATCACAGATGCAGCCACCATGAAGACATTCTGT
GGCACTCCAGAATATCTGGCACCAGAGGTGTTAGAAGATAATGACTATGGCCGAGCAGTAGACTGGTGGGGCCTAGGGGTTGTCATGTAT
GAAATGATGTGTGGGAGGTTACCTTTCTACAACCAGGACCATGAGAAACTTTTTGAATTAATATTAATGGAAGACATTAAATTTCCTCGA
ACACTCTCTTCAGATGCAAAATCATTGCTTTCAGGGCTCTTGATAAAGGATCCAAATAAACGCCTTGGTGGAGGACCAGATGATGCAAAA
GAAATTATGAGACACAGTTTCTTCTCTGGAGTAAACTGGCAAGATGTATATGATAAAAAGCTTGTACCTCCTTTTAAACCTCAAGTAACA
TCTGAGACAGATACTAGATATTTTGATGAAGAATTTACAGCTCAGACTATTACAATAACACCACCTGAAAAATATGATGAGGATGGTATG
GACTGCATGGACAATGAGAGGCGGCCGCATTTCCCTCAATTTTCCTACTCTGCAAGTGGACGAGAATAAGTCTCTTTCATTCTGCTACTT
CACTGTCATCTTCAATTTATTACTGAAAATGATTCCTGGACATCACCAGTCCTAGCTCTTACACATAGCAGGGGCACCTTCCGACATCCC
AGACCAGCCAAGGGTCCTCACCCCTCGCCACCTTTCACCCTCATGAAAACACACATACACGCAAATACACTCCAGTTTTTGTTTTTGCAT
GAAATTGTATCTCAGTCTAAGGTCTCATGCTGTTGCTGCTACTGTCTTACTATTATAGCAACTTTAAGAAGTAATTTTCCAACCTTTGGA
AGTCATGAGCCCACCATTGTTCATTTGTGCACCAATTATCATCTTTTGATCTTTTAGTTTTTCCCTCAGTGAAGGCTAAATGAGATACAC
TGATTCTAGGTACATTTTTTAACTTTCTAGAAGAGAAAAACTAACTAGACTAAGAAGATTTAGTTTATAAATTCAGAACAAGCAATTGTG
GAAGGGTGGTGGCGTGCATATGTAAAGCACATCAGATCCGTGCGTGAAGTAGGCATATATCACTAAGCTGTGGCTGGAATTGATTAGGAA
GCATTTGGTAGAAGGACTGAACAACTGTTGGGATATATATATATATATATAATTTTTTTTTTTTAAATTCCTGGTGGATACTGTAGAAGA
AGCCCATATCACATGTGGATGTCGAGACTTCACGGGCAATCATGAGCAAGTGAACACTGTTCTACCAAGAACTGAAGGCATATGCACAGT
CAAGGTCACTTAAAGGGTCTTATGAAACAATTTGAGCCAGAGAGCATCTTTCCCCTGTGCTTGGAAACCTTTTTTCCTTCTTGACATTTA
TCACCTCTGATGGCTGAAGAATGTAGACAGGTATAATGATACTGCTTTTCACCAAAATTTCTACACCAAGGTAAACAGGTGTTTGCCTTA
TTTAATTTTTTACTTTCAGTTCTACGTGAATTAGCTTTTTCTCAGATGTTGAAACTTTGAATGTCCTTTTATGATTTTGTTTATATTGCA
GTAGTATTTATTTTTTAGTGATGAGAATTGTATGTCATGTTAGCAAACGCAGCTCCAACTTATATAAAATAGACTTACTGCAGTTACTTT
TGACCCATGTGCAAGGATTGTACACGCTGATGAGAATCATGCACTTTTTCTCCTCTGTTAAAAAAAATGATAAGGCTCTGAAATGGAATA
TATTGGTTAGAATTTGGCTTTGGGAGAAGAGATGCTGCCATTTAACCCCTTGGTACTGAAAATGAGAAAATCCCCAACTATGCATGCCAA
GGGGTTAATGAAACAAATAGCTGTTGACGTTTGCTCATTTAAGAATTTGAAACGTTATGATGACCTGGCAACAAAAAGTAATGAAGAAAA
TTGAGACCTGAGTGAAGATAAGAAATGATCTTTACGTGGCAAAATGAACACATCTTGAGTATTTAGGAAATGGGCAGTGAAGGCTAAGAA
CCTGGTGTGTTTCTTGGGATCATGGTACATTTATCACTGAATTAAGCCATCAGGGAAAAAACAACAAAAAAAGAGAACACCTCCAGCTTT
TCTTTTTCTGTATATACTCATGTCCCCCAGATTCCAACATTTCTCACTGAAAGGGGGCATGTATGCAAACCTCATCTTTCTCCTTCATTA
ATGATGATCTTCAGATTAAACCCTTTGGTGCTAGGAGCTGACAATTTCCAAAGCAGCCTGTGAAGTCCTAGGGGCTGGGGGCCACTCTTG
CGGCAAGCAGAAGGCCATCCTACTCCGCGGAGTGATCATGGAAATGTATTTTAGTTAAACTCTGACAGCTCCCAAACGGAAGACTACAGC
ATGACGTAGTATTATGATTGCATTGTATGAAAGAGCAAGTGACTTTCTAAGTAGGATGAATCATATTCATATGCAGATGTCTTAGCCTCT
TGACGCTGGAAGTGTGGATTTATAGCTATGAAACCACTGCTGGCAGTGGGTGGGCCACTGGGACTGACGGGGGTTAAAGGGCATTTTACT
AAGGCAGCTAAGACATATTCAGACATCAACGTTATCCTTCTTTTTCATATTTCTACCTGAGTGAAGTTCATCCTTAGTATTGAGTAGGAA
GTTACAGTAAATGGTAGTTCATTCTTACTTACACACATAGCTAATCTTTTTTTTTTCACTTGGAATTATGTTGAATGTTTCATTTTGACA
AAAAAGTAGACTAGAAGGTATGTTCTTTAAGTTGTCTTGCATCCATTATATAAGAAAGAAACAGGTGAGAGGAAGAGCAGAAAGCTGAGA
CTGGCTGATGTTCAGAGCACTTACTCCTCTAGAGGGAAAGCATGACACCGAACACTAAGCACACAGCTTTTTGTTGTTTTGGTTTTTTCT
CCCGCAAATCTTAAAGTGATTCCCATGACCTTGGCCAAGGACACTTCTTAAAGATTAATGACTGGCACTGACATTGCCCCAGGCGGGCCA
CTCCTCACACTGGCTCTCAGTTCCCAGCCATGCCTGGGGCTCAGTCACTTCTATTCCACCCTCTGAGACTCCATTGGTGTCACACAAGGT
GTCTTCTTGGCTTTGATTTTGAGAATCCCCTATTTTCACTTCCAGATCTGTCAGCTGCCATGGAGGAATAATAGAAAACCAGAAATGCGT
GTAGAGGGAGATTTCTAAAACTTCCCTTGTGTCGCCCATAGTTGTAGTTTTGGGTTCTGGCAGGTGGAACACCCTGAAACCTGGAATCAT
TCTATGAGAATACAGTTCAGACTTTGCAGACTCCAGCCCATACTAACTGTCATGAAGCTTGACTTCTTGTCATAATGCAGCCATCTTGGA
GGAAATTGGCCATTTCTGCTTAGATGGTTGGCAGGGTCGCGCTCAGCTTTGCTTTCTACACTAATTACATAGCATTATTCAAGTATTGTT
TTCCATTTCCCATCCCTGATTTCCAGCTTCTTAAAGCTGACTGTTCTTGCAGGGGCCACTTGCTTCTCCTAGAGTACAAAAGTAAGGGCC
TTCCTTACTAACTGCAGGGTCTCTCTATTACACCTCAACATACACACTTTGCTGCTACTGTTTGTACTGTCTACAGTAGAATTTCCTTAT
CTTGCTCCTGGTAGTGCATTACAGGCAAGCATGAAATGTAAAGTATTTATTTAAATAAAAAGAAAACCTCTAAATTGGTAATTGAATTAC
CTCCCTGTAGCTTTATAGTTTGTGACATTTCTTGACCTTGCTAGTTCTTTCATTAGATCTGCGCAAGATCTAGTCATCTGGTTAAGGATT
TTAAGCAGATGCAACTATAAACCCAAGAAACTGTATTACTATTACTGTTGGTCATACTAAACCTGTCTATTTCCTGAAGTATATGACCCA
CAAGGATGTGGAATAACTAGGAGAAACTGTTTTTGTACACTGTACATCCTTAGTATTTTTACACGTATATGATAGGGATGAACATGATTT

>1904_1904_3_ACVR2A-AKT3_ACVR2A_chr2_148602776_ENST00000241416_AKT3_chr1_243828185_ENST00000366539_length(amino acids)=440AA_BP=18
MGAAAKLAFAVFLISCSSECQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIG
EEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKD
RLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGT
PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEI

--------------------------------------------------------------
>1904_1904_4_ACVR2A-AKT3_ACVR2A_chr2_148602776_ENST00000241416_AKT3_chr1_243828185_ENST00000366540_length(transcript)=1941nt_BP=691nt
AGGAGACCGAAAACGCGGCCGAGCCCGGAGCCCGGAGCTGGAGCCAGAGCCTGGACCAGAACTTGGCCGCCGCCTGCACCGCCGCCGCCG
CTGCCGCCCGCCGCCCCTTCCCCGCGCCGCAGCCGCCTCGCCGCCACCGCCGCGAGCTCGGCCGCCAGTGGTCCTCGGACTTTAGGTGTC
TGGGTTGAAGGTCGGTCCGGACATCGGACCCAGTCAGTTCCCAGACTGTCCGGGCGGCAGCGGACGCCGCTGCCGCCGCCGCCTCTTCGT
CGCCTCAGCCTGGCGTTTTGTTCCGAGAGACGGGAGAGGCGAGCGGAGCTGACAGTGATTTTGACAGTGATTTAAACCCGCTTTTGTTGT
TGTTGGCTTTTCGTTGTTTGGTTTTGTGTGTTGTGCGTGTGTGTGGCGGTTTTTCCCCCGTGGTGCATTTTATTTTTTATCGTTGTGCTC
TTTTTTTTCTTTTTTTTTTTTAACCCAGTGAGCGTTTTTTTTTTTTTTTTTTTTTTTTTTTGGTCTGGGCTTCCGAATATGTTTTATGAC
GGTTGATTTTACACCAGGAGGTTTGTCTCCGAGGAAGACCCAGGGAACTGGATATCTAGCGAGAACTTCCTCCGGATTCCCCGGCGCCTC
GGGAAAATGGGAGCTGCTGCAAAGTTGGCGTTTGCCGTCTTTCTTATCTCCTGTTCTTCAGAATGCCAGTTAATGAAAACAGAACGACCA
AAGCCAAACACATTTATAATCAGATGTCTCCAGTGGACTACTGTTATAGAGAGAACATTTCATGTAGATACTCCAGAGGAAAGGGAAGAA
TGGACAGAAGCTATCCAGGCTGTAGCAGACAGACTGCAGAGGCAAGAAGAGGAGAGAATGAATTGTAGTCCAACTTCACAAATTGATAAT
ATAGGAGAGGAAGAGATGGATGCCTCTACAACCCATCATAAAAGAAAGACAATGAATGATTTTGACTATTTGAAACTACTAGGTAAAGGC
ACTTTTGGGAAAGTTATTTTGGTTCGAGAGAAGGCAAGTGGAAAATACTATGCTATGAAGATTCTGAAGAAAGAAGTCATTATTGCAAAG
GATGAAGTGGCACACACTCTAACTGAAAGCAGAGTATTAAAGAACACTAGACATCCCTTTTTAACATCCTTGAAATATTCCTTCCAGACA
AAAGACCGTTTGTGTTTTGTGATGGAATATGTTAATGGGGGCGAGCTGTTTTTCCATTTGTCGAGAGAGCGGGTGTTCTCTGAGGACCGC
ACACGTTTCTATGGTGCAGAAATTGTCTCTGCCTTGGACTATCTACATTCCGGAAAGATTGTGTACCGTGATCTCAAGTTGGAGAATCTA
ATGCTGGACAAAGATGGCCACATAAAAATTACAGATTTTGGACTTTGCAAAGAAGGGATCACAGATGCAGCCACCATGAAGACATTCTGT
GGCACTCCAGAATATCTGGCACCAGAGGTGTTAGAAGATAATGACTATGGCCGAGCAGTAGACTGGTGGGGCCTAGGGGTTGTCATGTAT
GAAATGATGTGTGGGAGGTTACCTTTCTACAACCAGGACCATGAGAAACTTTTTGAATTAATATTAATGGAAGACATTAAATTTCCTCGA
ACACTCTCTTCAGATGCAAAATCATTGCTTTCAGGGCTCTTGATAAAGGATCCAAATAAACGCCTTGGTGGAGGACCAGATGATGCAAAA
GAAATTATGAGACACAGTTTCTTCTCTGGAGTAAACTGGCAAGATGTATATGATAAAAAGCTTGTACCTCCTTTTAAACCTCAAGTAACA
TCTGAGACAGATACTAGATATTTTGATGAAGAATTTACAGCTCAGACTATTACAATAACACCACCTGAAAAATGTCAGCAATCAGATTGT

>1904_1904_4_ACVR2A-AKT3_ACVR2A_chr2_148602776_ENST00000241416_AKT3_chr1_243828185_ENST00000366540_length(amino acids)=426AA_BP=18
MGAAAKLAFAVFLISCSSECQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIG
EEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKD
RLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGT
PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEI

--------------------------------------------------------------
>1904_1904_5_ACVR2A-AKT3_ACVR2A_chr2_148602776_ENST00000404590_AKT3_chr1_243828185_ENST00000263826_length(transcript)=3560nt_BP=225nt
GCCGCCCCTTCCCCGCGCCGCAGCCGCCTCGCCGCCACCGCCGCGAGCTCGGCCGCCAGTGGTCCTCGGACTTTAGGTGTCTGGGTTGAA
GGAGGTTTGTCTCCGAGGAAGACCCAGGGAACTGGATATCTAGCGAGAACTTCCTCCGGATTCCCCGGCGCCTCGGGAAAATGGGAGCTG
CTGCAAAGTTGGCGTTTGCCGTCTTTCTTATCTCCTGTTCTTCAGAATGCCAGTTAATGAAAACAGAACGACCAAAGCCAAACACATTTA
TAATCAGATGTCTCCAGTGGACTACTGTTATAGAGAGAACATTTCATGTAGATACTCCAGAGGAAAGGGAAGAATGGACAGAAGCTATCC
AGGCTGTAGCAGACAGACTGCAGAGGCAAGAAGAGGAGAGAATGAATTGTAGTCCAACTTCACAAATTGATAATATAGGAGAGGAAGAGA
TGGATGCCTCTACAACCCATCATAAAAGAAAGACAATGAATGATTTTGACTATTTGAAACTACTAGGTAAAGGCACTTTTGGGAAAGTTA
TTTTGGTTCGAGAGAAGGCAAGTGGAAAATACTATGCTATGAAGATTCTGAAGAAAGAAGTCATTATTGCAAAGGATGAAGTGGCACACA
CTCTAACTGAAAGCAGAGTATTAAAGAACACTAGACATCCCTTTTTAACATCCTTGAAATATTCCTTCCAGACAAAAGACCGTTTGTGTT
TTGTGATGGAATATGTTAATGGGGGCGAGCTGTTTTTCCATTTGTCGAGAGAGCGGGTGTTCTCTGAGGACCGCACACGTTTCTATGGTG
CAGAAATTGTCTCTGCCTTGGACTATCTACATTCCGGAAAGATTGTGTACCGTGATCTCAAGTTGGAGAATCTAATGCTGGACAAAGATG
GCCACATAAAAATTACAGATTTTGGACTTTGCAAAGAAGGGATCACAGATGCAGCCACCATGAAGACATTCTGTGGCACTCCAGAATATC
TGGCACCAGAGGTGTTAGAAGATAATGACTATGGCCGAGCAGTAGACTGGTGGGGCCTAGGGGTTGTCATGTATGAAATGATGTGTGGGA
GGTTACCTTTCTACAACCAGGACCATGAGAAACTTTTTGAATTAATATTAATGGAAGACATTAAATTTCCTCGAACACTCTCTTCAGATG
CAAAATCATTGCTTTCAGGGCTCTTGATAAAGGATCCAAATAAACGCCTTGGTGGAGGACCAGATGATGCAAAAGAAATTATGAGACACA
GTTTCTTCTCTGGAGTAAACTGGCAAGATGTATATGATAAAAAGCTTGTACCTCCTTTTAAACCTCAAGTAACATCTGAGACAGATACTA
GATATTTTGATGAAGAATTTACAGCTCAGACTATTACAATAACACCACCTGAAAAATATGATGAGGATGGTATGGACTGCATGGACAATG
AGAGGCGGCCGCATTTCCCTCAATTTTCCTACTCTGCAAGTGGACGAGAATAAGTCTCTTTCATTCTGCTACTTCACTGTCATCTTCAAT
TTATTACTGAAAATGATTCCTGGACATCACCAGTCCTAGCTCTTACACATAGCAGGGGCACCTTCCGACATCCCAGACCAGCCAAGGGTC
CTCACCCCTCGCCACCTTTCACCCTCATGAAAACACACATACACGCAAATACACTCCAGTTTTTGTTTTTGCATGAAATTGTATCTCAGT
CTAAGGTCTCATGCTGTTGCTGCTACTGTCTTACTATTATAGCAACTTTAAGAAGTAATTTTCCAACCTTTGGAAGTCATGAGCCCACCA
TTGTTCATTTGTGCACCAATTATCATCTTTTGATCTTTTAGTTTTTCCCTCAGTGAAGGCTAAATGAGATACACTGATTCTAGGTACATT
TTTTAACTTTCTAGAAGAGAAAAACTAACTAGACTAAGAAGATTTAGTTTATAAATTCAGAACAAGCAATTGTGGAAGGGTGGTGGCGTG
CATATGTAAAGCACATCAGATCCGTGCGTGAAGTAGGCATATATCACTAAGCTGTGGCTGGAATTGATTAGGAAGCATTTGGTAGAAGGA
CTGAACAACTGTTGGGATATATATATATATATATAATTTTTTTTTTTTAAATTCCTGGTGGATACTGTAGAAGAAGCCCATATCACATGT
GGATGTCGAGACTTCACGGGCAATCATGAGCAAGTGAACACTGTTCTACCAAGAACTGAAGGCATATGCACAGTCAAGGTCACTTAAAGG
GTCTTATGAAACAATTTGAGCCAGAGAGCATCTTTCCCCTGTGCTTGGAAACCTTTTTTCCTTCTTGACATTTATCACCTCTGATGGCTG
AAGAATGTAGACAGGTATAATGATACTGCTTTTCACCAAAATTTCTACACCAAGGTAAACAGGTGTTTGCCTTATTTAATTTTTTACTTT
CAGTTCTACGTGAATTAGCTTTTTCTCAGATGTTGAAACTTTGAATGTCCTTTTATGATTTTGTTTATATTGCAGTAGTATTTATTTTTT
AGTGATGAGAATTGTATGTCATGTTAGCAAACGCAGCTCCAACTTATATAAAATAGACTTACTGCAGTTACTTTTGACCCATGTGCAAGG
ATTGTACACGCTGATGAGAATCATGCACTTTTTCTCCTCTGTTAAAAAAAATGATAAGGCTCTGAAATGGAATATATTGGTTAGAATTTG
GCTTTGGGAGAAGAGATGCTGCCATTTAACCCCTTGGTACTGAAAATGAGAAAATCCCCAACTATGCATGCCAAGGGGTTAATGAAACAA
ATAGCTGTTGACGTTTGCTCATTTAAGAATTTGAAACGTTATGATGACCTGGCAACAAAAAGTAATGAAGAAAATTGAGACCTGAGTGAA
GATAAGAAATGATCTTTACGTGGCAAAATGAACACATCTTGAGTATTTAGGAAATGGGCAGTGAAGGCTAAGAACCTGGTGTGTTTCTTG
GGATCATGGTACATTTATCACTGAATTAAGCCATCAGGGAAAAAACAACAAAAAAAGAGAACACCTCCAGCTTTTCTTTTTCTGTATATA
CTCATGTCCCCCAGATTCCAACATTTCTCACTGAAAGGGGGCATGTATGCAAACCTCATCTTTCTCCTTCATTAATGATGATCTTCAGAT
TAAACCCTTTGGTGCTAGGAGCTGACAATTTCCAAAGCAGCCTGTGAAGTCCTAGGGGCTGGGGGCCACTCTTGCGGCAAGCAGAAGGCC
ATCCTACTCCGCGGAGTGATCATGGAAATGTATTTTAGTTAAACTCTGACAGCTCCCAAACGGAAGACTACAGCATGACGTAGTATTATG
ATTGCATTGTATGAAAGAGCAAGTGACTTTCTAAGTAGGATGAATCATATTCATATGCAGATGTCTTAGCCTCTTGACGCTGGAAGTGTG
GATTTATAGCTATGAAACCACTGCTGGCAGTGGGTGGGCCACTGGGACTGACGGGGGTTAAAGGGCATTTTACTAAGGCAGCTAAGACAT

>1904_1904_5_ACVR2A-AKT3_ACVR2A_chr2_148602776_ENST00000404590_AKT3_chr1_243828185_ENST00000263826_length(amino acids)=440AA_BP=18
MGAAAKLAFAVFLISCSSECQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIG
EEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKD
RLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGT
PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEI

--------------------------------------------------------------
>1904_1904_6_ACVR2A-AKT3_ACVR2A_chr2_148602776_ENST00000404590_AKT3_chr1_243828185_ENST00000336199_length(transcript)=1675nt_BP=225nt
GCCGCCCCTTCCCCGCGCCGCAGCCGCCTCGCCGCCACCGCCGCGAGCTCGGCCGCCAGTGGTCCTCGGACTTTAGGTGTCTGGGTTGAA
GGAGGTTTGTCTCCGAGGAAGACCCAGGGAACTGGATATCTAGCGAGAACTTCCTCCGGATTCCCCGGCGCCTCGGGAAAATGGGAGCTG
CTGCAAAGTTGGCGTTTGCCGTCTTTCTTATCTCCTGTTCTTCAGAATGCCAGTTAATGAAAACAGAACGACCAAAGCCAAACACATTTA
TAATCAGATGTCTCCAGTGGACTACTGTTATAGAGAGAACATTTCATGTAGATACTCCAGAGGAAAGGGAAGAATGGACAGAAGCTATCC
AGGCTGTAGCAGACAGACTGCAGAGGCAAGAAGAGGAGAGAATGAATTGTAGTCCAACTTCACAAATTGATAATATAGGAGAGGAAGAGA
TGGATGCCTCTACAACCCATCATAAAAGAAAGACAATGAATGATTTTGACTATTTGAAACTACTAGGTAAAGGCACTTTTGGGAAAGTTA
TTTTGGTTCGAGAGAAGGCAAGTGGAAAATACTATGCTATGAAGATTCTGAAGAAAGAAGTCATTATTGCAAAGGATGAAGTGGCACACA
CTCTAACTGAAAGCAGAGTATTAAAGAACACTAGACATCCCTTTTTAACATCCTTGAAATATTCCTTCCAGACAAAAGACCGTTTGTGTT
TTGTGATGGAATATGTTAATGGGGGCGAGCTGTTTTTCCATTTGTCGAGAGAGCGGGTGTTCTCTGAGGACCGCACACGTTTCTATGGTG
CAGAAATTGTCTCTGCCTTGGACTATCTACATTCCGGAAAGATTGTGTACCGTGATCTCAAGTTGGAGAATCTAATGCTGGACAAAGATG
GCCACATAAAAATTACAGATTTTGGACTTTGCAAAGAAGGGATCACAGATGCAGCCACCATGAAGACATTCTGTGGCACTCCAGAATATC
TGGCACCAGAGGTGTTAGAAGATAATGACTATGGCCGAGCAGTAGACTGGTGGGGCCTAGGGGTTGTCATGTATGAAATGATGTGTGGGA
GGTTACCTTTCTACAACCAGGACCATGAGAAACTTTTTGAATTAATATTAATGGAAGACATTAAATTTCCTCGAACACTCTCTTCAGATG
CAAAATCATTGCTTTCAGGGCTCTTGATAAAGGATCCAAATAAACGCCTTGGTGGAGGACCAGATGATGCAAAAGAAATTATGAGACACA
GTTTCTTCTCTGGAGTAAACTGGCAAGATGTATATGATAAAAAGCTTGTACCTCCTTTTAAACCTCAAGTAACATCTGAGACAGATACTA
GATATTTTGATGAAGAATTTACAGCTCAGACTATTACAATAACACCACCTGAAAAATGTCAGCAATCAGATTGTGGCATGCTGGGTAACT
GGAAAAAATAATAAAAATCGGCTTCCTACAGCCAGCAGCACAGTCACCCATGGAACTGTTGGCTTTGGATTAAATGTGGAATTGAACGAC
TACCCAGAAGTGTTCTGGAAAGAAGCGAGATGTGTGGCCTGCCTCACCGTCCTCACCCATCAAAAGCACCAGCAGGCACGTTAACTCGAA

>1904_1904_6_ACVR2A-AKT3_ACVR2A_chr2_148602776_ENST00000404590_AKT3_chr1_243828185_ENST00000336199_length(amino acids)=426AA_BP=18
MGAAAKLAFAVFLISCSSECQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIG
EEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKD
RLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGT
PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEI

--------------------------------------------------------------
>1904_1904_7_ACVR2A-AKT3_ACVR2A_chr2_148602776_ENST00000404590_AKT3_chr1_243828185_ENST00000366539_length(transcript)=4979nt_BP=225nt
GCCGCCCCTTCCCCGCGCCGCAGCCGCCTCGCCGCCACCGCCGCGAGCTCGGCCGCCAGTGGTCCTCGGACTTTAGGTGTCTGGGTTGAA
GGAGGTTTGTCTCCGAGGAAGACCCAGGGAACTGGATATCTAGCGAGAACTTCCTCCGGATTCCCCGGCGCCTCGGGAAAATGGGAGCTG
CTGCAAAGTTGGCGTTTGCCGTCTTTCTTATCTCCTGTTCTTCAGAATGCCAGTTAATGAAAACAGAACGACCAAAGCCAAACACATTTA
TAATCAGATGTCTCCAGTGGACTACTGTTATAGAGAGAACATTTCATGTAGATACTCCAGAGGAAAGGGAAGAATGGACAGAAGCTATCC
AGGCTGTAGCAGACAGACTGCAGAGGCAAGAAGAGGAGAGAATGAATTGTAGTCCAACTTCACAAATTGATAATATAGGAGAGGAAGAGA
TGGATGCCTCTACAACCCATCATAAAAGAAAGACAATGAATGATTTTGACTATTTGAAACTACTAGGTAAAGGCACTTTTGGGAAAGTTA
TTTTGGTTCGAGAGAAGGCAAGTGGAAAATACTATGCTATGAAGATTCTGAAGAAAGAAGTCATTATTGCAAAGGATGAAGTGGCACACA
CTCTAACTGAAAGCAGAGTATTAAAGAACACTAGACATCCCTTTTTAACATCCTTGAAATATTCCTTCCAGACAAAAGACCGTTTGTGTT
TTGTGATGGAATATGTTAATGGGGGCGAGCTGTTTTTCCATTTGTCGAGAGAGCGGGTGTTCTCTGAGGACCGCACACGTTTCTATGGTG
CAGAAATTGTCTCTGCCTTGGACTATCTACATTCCGGAAAGATTGTGTACCGTGATCTCAAGTTGGAGAATCTAATGCTGGACAAAGATG
GCCACATAAAAATTACAGATTTTGGACTTTGCAAAGAAGGGATCACAGATGCAGCCACCATGAAGACATTCTGTGGCACTCCAGAATATC
TGGCACCAGAGGTGTTAGAAGATAATGACTATGGCCGAGCAGTAGACTGGTGGGGCCTAGGGGTTGTCATGTATGAAATGATGTGTGGGA
GGTTACCTTTCTACAACCAGGACCATGAGAAACTTTTTGAATTAATATTAATGGAAGACATTAAATTTCCTCGAACACTCTCTTCAGATG
CAAAATCATTGCTTTCAGGGCTCTTGATAAAGGATCCAAATAAACGCCTTGGTGGAGGACCAGATGATGCAAAAGAAATTATGAGACACA
GTTTCTTCTCTGGAGTAAACTGGCAAGATGTATATGATAAAAAGCTTGTACCTCCTTTTAAACCTCAAGTAACATCTGAGACAGATACTA
GATATTTTGATGAAGAATTTACAGCTCAGACTATTACAATAACACCACCTGAAAAATATGATGAGGATGGTATGGACTGCATGGACAATG
AGAGGCGGCCGCATTTCCCTCAATTTTCCTACTCTGCAAGTGGACGAGAATAAGTCTCTTTCATTCTGCTACTTCACTGTCATCTTCAAT
TTATTACTGAAAATGATTCCTGGACATCACCAGTCCTAGCTCTTACACATAGCAGGGGCACCTTCCGACATCCCAGACCAGCCAAGGGTC
CTCACCCCTCGCCACCTTTCACCCTCATGAAAACACACATACACGCAAATACACTCCAGTTTTTGTTTTTGCATGAAATTGTATCTCAGT
CTAAGGTCTCATGCTGTTGCTGCTACTGTCTTACTATTATAGCAACTTTAAGAAGTAATTTTCCAACCTTTGGAAGTCATGAGCCCACCA
TTGTTCATTTGTGCACCAATTATCATCTTTTGATCTTTTAGTTTTTCCCTCAGTGAAGGCTAAATGAGATACACTGATTCTAGGTACATT
TTTTAACTTTCTAGAAGAGAAAAACTAACTAGACTAAGAAGATTTAGTTTATAAATTCAGAACAAGCAATTGTGGAAGGGTGGTGGCGTG
CATATGTAAAGCACATCAGATCCGTGCGTGAAGTAGGCATATATCACTAAGCTGTGGCTGGAATTGATTAGGAAGCATTTGGTAGAAGGA
CTGAACAACTGTTGGGATATATATATATATATATAATTTTTTTTTTTTAAATTCCTGGTGGATACTGTAGAAGAAGCCCATATCACATGT
GGATGTCGAGACTTCACGGGCAATCATGAGCAAGTGAACACTGTTCTACCAAGAACTGAAGGCATATGCACAGTCAAGGTCACTTAAAGG
GTCTTATGAAACAATTTGAGCCAGAGAGCATCTTTCCCCTGTGCTTGGAAACCTTTTTTCCTTCTTGACATTTATCACCTCTGATGGCTG
AAGAATGTAGACAGGTATAATGATACTGCTTTTCACCAAAATTTCTACACCAAGGTAAACAGGTGTTTGCCTTATTTAATTTTTTACTTT
CAGTTCTACGTGAATTAGCTTTTTCTCAGATGTTGAAACTTTGAATGTCCTTTTATGATTTTGTTTATATTGCAGTAGTATTTATTTTTT
AGTGATGAGAATTGTATGTCATGTTAGCAAACGCAGCTCCAACTTATATAAAATAGACTTACTGCAGTTACTTTTGACCCATGTGCAAGG
ATTGTACACGCTGATGAGAATCATGCACTTTTTCTCCTCTGTTAAAAAAAATGATAAGGCTCTGAAATGGAATATATTGGTTAGAATTTG
GCTTTGGGAGAAGAGATGCTGCCATTTAACCCCTTGGTACTGAAAATGAGAAAATCCCCAACTATGCATGCCAAGGGGTTAATGAAACAA
ATAGCTGTTGACGTTTGCTCATTTAAGAATTTGAAACGTTATGATGACCTGGCAACAAAAAGTAATGAAGAAAATTGAGACCTGAGTGAA
GATAAGAAATGATCTTTACGTGGCAAAATGAACACATCTTGAGTATTTAGGAAATGGGCAGTGAAGGCTAAGAACCTGGTGTGTTTCTTG
GGATCATGGTACATTTATCACTGAATTAAGCCATCAGGGAAAAAACAACAAAAAAAGAGAACACCTCCAGCTTTTCTTTTTCTGTATATA
CTCATGTCCCCCAGATTCCAACATTTCTCACTGAAAGGGGGCATGTATGCAAACCTCATCTTTCTCCTTCATTAATGATGATCTTCAGAT
TAAACCCTTTGGTGCTAGGAGCTGACAATTTCCAAAGCAGCCTGTGAAGTCCTAGGGGCTGGGGGCCACTCTTGCGGCAAGCAGAAGGCC
ATCCTACTCCGCGGAGTGATCATGGAAATGTATTTTAGTTAAACTCTGACAGCTCCCAAACGGAAGACTACAGCATGACGTAGTATTATG
ATTGCATTGTATGAAAGAGCAAGTGACTTTCTAAGTAGGATGAATCATATTCATATGCAGATGTCTTAGCCTCTTGACGCTGGAAGTGTG
GATTTATAGCTATGAAACCACTGCTGGCAGTGGGTGGGCCACTGGGACTGACGGGGGTTAAAGGGCATTTTACTAAGGCAGCTAAGACAT
ATTCAGACATCAACGTTATCCTTCTTTTTCATATTTCTACCTGAGTGAAGTTCATCCTTAGTATTGAGTAGGAAGTTACAGTAAATGGTA
GTTCATTCTTACTTACACACATAGCTAATCTTTTTTTTTTCACTTGGAATTATGTTGAATGTTTCATTTTGACAAAAAAGTAGACTAGAA
GGTATGTTCTTTAAGTTGTCTTGCATCCATTATATAAGAAAGAAACAGGTGAGAGGAAGAGCAGAAAGCTGAGACTGGCTGATGTTCAGA
GCACTTACTCCTCTAGAGGGAAAGCATGACACCGAACACTAAGCACACAGCTTTTTGTTGTTTTGGTTTTTTCTCCCGCAAATCTTAAAG
TGATTCCCATGACCTTGGCCAAGGACACTTCTTAAAGATTAATGACTGGCACTGACATTGCCCCAGGCGGGCCACTCCTCACACTGGCTC
TCAGTTCCCAGCCATGCCTGGGGCTCAGTCACTTCTATTCCACCCTCTGAGACTCCATTGGTGTCACACAAGGTGTCTTCTTGGCTTTGA
TTTTGAGAATCCCCTATTTTCACTTCCAGATCTGTCAGCTGCCATGGAGGAATAATAGAAAACCAGAAATGCGTGTAGAGGGAGATTTCT
AAAACTTCCCTTGTGTCGCCCATAGTTGTAGTTTTGGGTTCTGGCAGGTGGAACACCCTGAAACCTGGAATCATTCTATGAGAATACAGT
TCAGACTTTGCAGACTCCAGCCCATACTAACTGTCATGAAGCTTGACTTCTTGTCATAATGCAGCCATCTTGGAGGAAATTGGCCATTTC
TGCTTAGATGGTTGGCAGGGTCGCGCTCAGCTTTGCTTTCTACACTAATTACATAGCATTATTCAAGTATTGTTTTCCATTTCCCATCCC
TGATTTCCAGCTTCTTAAAGCTGACTGTTCTTGCAGGGGCCACTTGCTTCTCCTAGAGTACAAAAGTAAGGGCCTTCCTTACTAACTGCA
GGGTCTCTCTATTACACCTCAACATACACACTTTGCTGCTACTGTTTGTACTGTCTACAGTAGAATTTCCTTATCTTGCTCCTGGTAGTG
CATTACAGGCAAGCATGAAATGTAAAGTATTTATTTAAATAAAAAGAAAACCTCTAAATTGGTAATTGAATTACCTCCCTGTAGCTTTAT
AGTTTGTGACATTTCTTGACCTTGCTAGTTCTTTCATTAGATCTGCGCAAGATCTAGTCATCTGGTTAAGGATTTTAAGCAGATGCAACT
ATAAACCCAAGAAACTGTATTACTATTACTGTTGGTCATACTAAACCTGTCTATTTCCTGAAGTATATGACCCACAAGGATGTGGAATAA
CTAGGAGAAACTGTTTTTGTACACTGTACATCCTTAGTATTTTTACACGTATATGATAGGGATGAACATGATTTTCCTTCGTACAGACAG

>1904_1904_7_ACVR2A-AKT3_ACVR2A_chr2_148602776_ENST00000404590_AKT3_chr1_243828185_ENST00000366539_length(amino acids)=440AA_BP=18
MGAAAKLAFAVFLISCSSECQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIG
EEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKD
RLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGT
PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEI

--------------------------------------------------------------
>1904_1904_8_ACVR2A-AKT3_ACVR2A_chr2_148602776_ENST00000404590_AKT3_chr1_243828185_ENST00000366540_length(transcript)=1475nt_BP=225nt
GCCGCCCCTTCCCCGCGCCGCAGCCGCCTCGCCGCCACCGCCGCGAGCTCGGCCGCCAGTGGTCCTCGGACTTTAGGTGTCTGGGTTGAA
GGAGGTTTGTCTCCGAGGAAGACCCAGGGAACTGGATATCTAGCGAGAACTTCCTCCGGATTCCCCGGCGCCTCGGGAAAATGGGAGCTG
CTGCAAAGTTGGCGTTTGCCGTCTTTCTTATCTCCTGTTCTTCAGAATGCCAGTTAATGAAAACAGAACGACCAAAGCCAAACACATTTA
TAATCAGATGTCTCCAGTGGACTACTGTTATAGAGAGAACATTTCATGTAGATACTCCAGAGGAAAGGGAAGAATGGACAGAAGCTATCC
AGGCTGTAGCAGACAGACTGCAGAGGCAAGAAGAGGAGAGAATGAATTGTAGTCCAACTTCACAAATTGATAATATAGGAGAGGAAGAGA
TGGATGCCTCTACAACCCATCATAAAAGAAAGACAATGAATGATTTTGACTATTTGAAACTACTAGGTAAAGGCACTTTTGGGAAAGTTA
TTTTGGTTCGAGAGAAGGCAAGTGGAAAATACTATGCTATGAAGATTCTGAAGAAAGAAGTCATTATTGCAAAGGATGAAGTGGCACACA
CTCTAACTGAAAGCAGAGTATTAAAGAACACTAGACATCCCTTTTTAACATCCTTGAAATATTCCTTCCAGACAAAAGACCGTTTGTGTT
TTGTGATGGAATATGTTAATGGGGGCGAGCTGTTTTTCCATTTGTCGAGAGAGCGGGTGTTCTCTGAGGACCGCACACGTTTCTATGGTG
CAGAAATTGTCTCTGCCTTGGACTATCTACATTCCGGAAAGATTGTGTACCGTGATCTCAAGTTGGAGAATCTAATGCTGGACAAAGATG
GCCACATAAAAATTACAGATTTTGGACTTTGCAAAGAAGGGATCACAGATGCAGCCACCATGAAGACATTCTGTGGCACTCCAGAATATC
TGGCACCAGAGGTGTTAGAAGATAATGACTATGGCCGAGCAGTAGACTGGTGGGGCCTAGGGGTTGTCATGTATGAAATGATGTGTGGGA
GGTTACCTTTCTACAACCAGGACCATGAGAAACTTTTTGAATTAATATTAATGGAAGACATTAAATTTCCTCGAACACTCTCTTCAGATG
CAAAATCATTGCTTTCAGGGCTCTTGATAAAGGATCCAAATAAACGCCTTGGTGGAGGACCAGATGATGCAAAAGAAATTATGAGACACA
GTTTCTTCTCTGGAGTAAACTGGCAAGATGTATATGATAAAAAGCTTGTACCTCCTTTTAAACCTCAAGTAACATCTGAGACAGATACTA
GATATTTTGATGAAGAATTTACAGCTCAGACTATTACAATAACACCACCTGAAAAATGTCAGCAATCAGATTGTGGCATGCTGGGTAACT

>1904_1904_8_ACVR2A-AKT3_ACVR2A_chr2_148602776_ENST00000404590_AKT3_chr1_243828185_ENST00000366540_length(amino acids)=426AA_BP=18
MGAAAKLAFAVFLISCSSECQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIG
EEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKD
RLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGT
PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ACVR2A-AKT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACVR2A-AKT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACVR2A-AKT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACVR2AC0920269Microsatellite Instability1CTD_human
HgeneACVR2AC1721098Replication Error Phenotype1CTD_human
TgeneC4014738MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 24GENOMICS_ENGLAND;UNIPROT
TgeneC4012727MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 12GENOMICS_ENGLAND
TgeneC0152427Polydactyly1GENOMICS_ENGLAND
TgeneC0431380Cortical Dysplasia1CTD_human
TgeneC0431391Hemimegalencephaly1ORPHANET
TgeneC1863924Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome1CTD_human;ORPHANET
TgeneC1955869Malformations of Cortical Development1CTD_human