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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAP4K4-MBNL2 (FusionGDB2 ID:HG9448TG10150)

Fusion Gene Summary for MAP4K4-MBNL2

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP4K4-MBNL2
Fusion gene ID: hg9448tg10150
HgeneTgene
Gene symbol

MAP4K4

MBNL2

Gene ID

9448

10150

Gene namemitogen-activated protein kinase kinase kinase kinase 4muscleblind like splicing regulator 2
SynonymsFLH21957|HEL-S-31|HGK|MEKKK4|NIKMBLL|MBLL39|PRO2032
Cytomap('MAP4K4')('MBNL2')

2q11.2

13q32.1

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase kinase kinase kinase 4HPK/GCK-like kinase HGKMAPK/ERK kinase kinase kinase 4MEK kinase kinase 4Ste20 group protein kinase HGKepididymis secretory protein Li 31hepatocyte progenitor kinase-like/germinal center kinase-muscleblind-like protein 2muscleblind-like 2muscleblind-like protein 1muscleblind-like protein-like 39
Modification date2020031520200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000302217, ENST00000324219, 
ENST00000347699, ENST00000350198, 
ENST00000413150, ENST00000425019, 
ENST00000456652, ENST00000350878, 
ENST00000498066, 
Fusion gene scores* DoF score16 X 11 X 9=15847 X 8 X 5=280
# samples 169
** MAII scorelog2(16/1584*10)=-3.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAP4K4 [Title/Abstract] AND MBNL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAP4K4(102315000)-MBNL2(98043576), # samples:1
Anticipated loss of major functional domain due to fusion event.MAP4K4-MBNL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MAP4K4-MBNL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MAP4K4-MBNL2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
MAP4K4-MBNL2 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
MAP4K4-MBNL2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
MAP4K4-MBNL2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAP4K4

GO:0006468

protein phosphorylation

9890973

HgeneMAP4K4

GO:0035556

intracellular signal transduction

9890973

HgeneMAP4K4

GO:0046328

regulation of JNK cascade

14966141

TgeneMBNL2

GO:0043484

regulation of RNA splicing

15257297|16946708


check buttonFusion gene breakpoints across MAP4K4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MBNL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-DA-A1HW-06AMAP4K4chr2

102315000

+MBNL2chr13

98043576

+


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Fusion Gene ORF analysis for MAP4K4-MBNL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000302217ENST00000376673MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
Frame-shiftENST00000302217ENST00000397601MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
Frame-shiftENST00000302217ENST00000445661MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
Frame-shiftENST00000324219ENST00000376673MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
Frame-shiftENST00000324219ENST00000397601MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
Frame-shiftENST00000324219ENST00000445661MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
Frame-shiftENST00000347699ENST00000376673MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
Frame-shiftENST00000347699ENST00000397601MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
Frame-shiftENST00000347699ENST00000445661MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
Frame-shiftENST00000350198ENST00000376673MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
Frame-shiftENST00000350198ENST00000397601MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
Frame-shiftENST00000350198ENST00000445661MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
Frame-shiftENST00000413150ENST00000376673MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
Frame-shiftENST00000413150ENST00000397601MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
Frame-shiftENST00000413150ENST00000445661MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
Frame-shiftENST00000425019ENST00000376673MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
Frame-shiftENST00000425019ENST00000397601MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
Frame-shiftENST00000425019ENST00000445661MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
Frame-shiftENST00000456652ENST00000376673MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
Frame-shiftENST00000456652ENST00000397601MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
Frame-shiftENST00000456652ENST00000445661MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
In-frameENST00000302217ENST00000343600MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
In-frameENST00000302217ENST00000345429MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
In-frameENST00000324219ENST00000343600MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
In-frameENST00000324219ENST00000345429MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
In-frameENST00000347699ENST00000343600MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
In-frameENST00000347699ENST00000345429MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
In-frameENST00000350198ENST00000343600MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
In-frameENST00000350198ENST00000345429MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
In-frameENST00000413150ENST00000343600MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
In-frameENST00000413150ENST00000345429MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
In-frameENST00000425019ENST00000343600MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
In-frameENST00000425019ENST00000345429MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
In-frameENST00000456652ENST00000343600MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
In-frameENST00000456652ENST00000345429MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
intron-3CDSENST00000350878ENST00000343600MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
intron-3CDSENST00000350878ENST00000345429MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
intron-3CDSENST00000350878ENST00000376673MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
intron-3CDSENST00000350878ENST00000397601MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
intron-3CDSENST00000350878ENST00000445661MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
intron-3CDSENST00000498066ENST00000343600MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
intron-3CDSENST00000498066ENST00000345429MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
intron-3CDSENST00000498066ENST00000376673MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
intron-3CDSENST00000498066ENST00000397601MAP4K4chr2

102315000

+MBNL2chr13

98043576

+
intron-3CDSENST00000498066ENST00000445661MAP4K4chr2

102315000

+MBNL2chr13

98043576

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000425019MAP4K4chr2102315000+ENST00000343600MBNL2chr1398043576+32584604812160
ENST00000425019MAP4K4chr2102315000+ENST00000345429MBNL2chr1398043576+32594603740125
ENST00000324219MAP4K4chr2102315000+ENST00000343600MBNL2chr1398043576+29951971474169874
ENST00000324219MAP4K4chr2102315000+ENST00000345429MBNL2chr1398043576+29961971474169874
ENST00000350198MAP4K4chr2102315000+ENST00000343600MBNL2chr1398043576+29951971474169874
ENST00000350198MAP4K4chr2102315000+ENST00000345429MBNL2chr1398043576+29961971474169874
ENST00000302217MAP4K4chr2102315000+ENST00000343600MBNL2chr1398043576+29951971474169874
ENST00000302217MAP4K4chr2102315000+ENST00000345429MBNL2chr1398043576+29961971474169874
ENST00000413150MAP4K4chr2102315000+ENST00000343600MBNL2chr1398043576+29761781455167974
ENST00000413150MAP4K4chr2102315000+ENST00000345429MBNL2chr1398043576+29771781455167974
ENST00000347699MAP4K4chr2102315000+ENST00000343600MBNL2chr1398043576+29211231400162474
ENST00000347699MAP4K4chr2102315000+ENST00000345429MBNL2chr1398043576+29221231400162474
ENST00000456652MAP4K4chr2102315000+ENST00000343600MBNL2chr1398043576+29211231400162474
ENST00000456652MAP4K4chr2102315000+ENST00000345429MBNL2chr1398043576+29221231400162474

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000425019ENST00000343600MAP4K4chr2102315000+MBNL2chr1398043576+0.482176360.51782364
ENST00000425019ENST00000345429MAP4K4chr2102315000+MBNL2chr1398043576+0.458935860.54106414
ENST00000324219ENST00000343600MAP4K4chr2102315000+MBNL2chr1398043576+0.76503910.23496087
ENST00000324219ENST00000345429MAP4K4chr2102315000+MBNL2chr1398043576+0.76594750.23405254
ENST00000350198ENST00000343600MAP4K4chr2102315000+MBNL2chr1398043576+0.76503910.23496087
ENST00000350198ENST00000345429MAP4K4chr2102315000+MBNL2chr1398043576+0.76594750.23405254
ENST00000302217ENST00000343600MAP4K4chr2102315000+MBNL2chr1398043576+0.76503910.23496087
ENST00000302217ENST00000345429MAP4K4chr2102315000+MBNL2chr1398043576+0.76594750.23405254
ENST00000413150ENST00000343600MAP4K4chr2102315000+MBNL2chr1398043576+0.66382010.33617988
ENST00000413150ENST00000345429MAP4K4chr2102315000+MBNL2chr1398043576+0.63764170.36235824
ENST00000347699ENST00000343600MAP4K4chr2102315000+MBNL2chr1398043576+0.402853520.5971465
ENST00000347699ENST00000345429MAP4K4chr2102315000+MBNL2chr1398043576+0.401309730.5986903
ENST00000456652ENST00000343600MAP4K4chr2102315000+MBNL2chr1398043576+0.402853520.5971465
ENST00000456652ENST00000345429MAP4K4chr2102315000+MBNL2chr1398043576+0.401309730.5986903

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Fusion Genomic Features for MAP4K4-MBNL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MAP4K4-MBNL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:102315000/chr13:98043576)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP4K4chr2:102315000chr13:98043576ENST00000347699+23031_39411240.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP4K4chr2:102315000chr13:98043576ENST00000347699+23025_289411240.0DomainProtein kinase
HgeneMAP4K4chr2:102315000chr13:98043576ENST00000347699+230926_1213411240.0DomainCNH
TgeneMBNL2chr2:102315000chr13:98043576ENST000003436005713_41319362.0Zinc fingerC3H1-type 1
TgeneMBNL2chr2:102315000chr13:98043576ENST0000034360057176_204319362.0Zinc fingerC3H1-type 3
TgeneMBNL2chr2:102315000chr13:98043576ENST0000034360057212_238319362.0Zinc fingerC3H1-type 4
TgeneMBNL2chr2:102315000chr13:98043576ENST000003436005747_73319362.0Zinc fingerC3H1-type 2
TgeneMBNL2chr2:102315000chr13:98043576ENST000003454297913_41363368.0Zinc fingerC3H1-type 1
TgeneMBNL2chr2:102315000chr13:98043576ENST0000034542979176_204363368.0Zinc fingerC3H1-type 3
TgeneMBNL2chr2:102315000chr13:98043576ENST0000034542979212_238363368.0Zinc fingerC3H1-type 4
TgeneMBNL2chr2:102315000chr13:98043576ENST000003454297947_73363368.0Zinc fingerC3H1-type 2
TgeneMBNL2chr2:102315000chr13:98043576ENST000003766736813_41331374.0Zinc fingerC3H1-type 1
TgeneMBNL2chr2:102315000chr13:98043576ENST0000037667368176_204331374.0Zinc fingerC3H1-type 3
TgeneMBNL2chr2:102315000chr13:98043576ENST0000037667368212_238331374.0Zinc fingerC3H1-type 4
TgeneMBNL2chr2:102315000chr13:98043576ENST000003766736847_73331374.0Zinc fingerC3H1-type 2
TgeneMBNL2chr2:102315000chr13:98043576ENST000003976015713_41319362.0Zinc fingerC3H1-type 1
TgeneMBNL2chr2:102315000chr13:98043576ENST0000039760157176_204319362.0Zinc fingerC3H1-type 3
TgeneMBNL2chr2:102315000chr13:98043576ENST0000039760157212_238319362.0Zinc fingerC3H1-type 4
TgeneMBNL2chr2:102315000chr13:98043576ENST000003976015747_73319362.0Zinc fingerC3H1-type 2


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Fusion Gene Sequence for MAP4K4-MBNL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>51408_51408_1_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000302217_MBNL2_chr13_98043576_ENST00000343600_length(transcript)=2995nt_BP=197nt
CTGGTCTGCGGCTGAGATACACAGAGCGACAGAGACATTTATTGTTATTTGTTTTTTGGTGGCAAAAAGGGAAAATGGCGAACGACTCCC
CTGCAAAAAGTCTGGTGGACATCGACCTCTCCTCCCTGCGGGATCCTGCTGGGATTTTTGAGCTGGTGGAAGTGGTTGGAAATGGCACCT
ATGGACAAGTCTATAAGATAATTCTGAAATAATCAGCAGAAACGGAATGGAATGCCAAGAATCTGCATTGAGAATAACTAAACATTGTTA
CTGTACATACTATCCTGTTTCCTCCTCAATAGAATTGCCACAAACTGCATGCTAAATAAAGATGTAGTTCTTCTGGACAGACCACAACTC
TAAGAAGCTAGTGCTGCTATCTCATATATGAGTATTAAATATGGTATGCTTAGTATATTCCAACCTAAGATAGTTAACTACCTGAGACCA
GCTGTGATGTTTAAAGACATAAAGGATAAAGTTTACTTTTAAAGGGTTTCTAAACATAGTTTCTGTCCTAGGAATATTGTCTTATCTCCA
TAACTATAGCTGATGCAGAAAGTCCAGCCAGTTTACTCATTTCGATTCAGAATATTTCAAATTTAGCAATAAACAATTAGCATTAGTTAA
AAAAGAAACATATTCCAAGGGCAGGTTCGATTCTAGCTCTAATTACTGTCATGTCATTTACCCACTGGATCAAAGGGTATGTTTCACTTC
TTGACAATATAAATGCTGCAGCAAAGATGAGAGGTGAAGTAAAACCGATACCTGTCCTGCAGGTCTAAAATTTGAATGGAAATTCAAGCA
CAAGTACTGGGGACACATCAAAGTGTGGTGTTTGGTTTGCCTGGAGATGCCACGTTGAATCATGTGATTCTAGATTAACATTAAATAGAT
TGAAAAAGAAACTTTGCACGGTATGAGCTTCATACCCCACCAAACAAAGTCTTGAAGGTATTATTTTACAAGTATATTTTTAAAGTTGTT
TTATAAGAGAGACTTTGTAGAAGTGCCTAGATTTTGCCAGACTTCATCCAGCTTGACAAGATTGAGAGGCCCATGCCAACAGTCTAATCT
AAGAGATTAGTCTTTCAAACTCACCATCCAGTTGCCTGTTACAGAATAACTCTTCTTAACTAAAAACCTAGTCAAACAAGGAAGCTGTAG
GTGAGGAGATCTGTATAATATTCTAATTTAAGTAAGTTTGAGTTTAGTCACTGCAAATTTGACTGTGACTTTAATCTAAATTACTATGTA
AACAAAAAGTAGATAGTTTCACTTTTTAAAAAATCCATTACTGTTTTGCATTTCAAAAGTTGGATTAAAGGGTTGTAACTGACTACAGCA
TGGAAAAAAATAGTTCTTTTAATTCTTTCACCTTAAAGCATATTTTATGTCTCAAAAGTATAAAAAACTTTAATACAAGTACATACATAT
TATATATACACATACATATATATACTATATATGGATGAAACATATTTTAATGTTGTTTACTTTTTTAAATACTTGGTTGATCTTCAAGGT
AATAGCGATACAATTAAATTTTGTTCAGAAAGTTTGTTTTAAAGTTTATTTTAAGCACTATCGTACCAAATATTTCATATTTCACATTTT
ATATGTTGCACATAGCCTATACAGTACCTACATAGTTTTTAAATTATTGTTTAAAAAACAAAACAGCTGTTATAAATGAATATTATGTGT
AATTGTTTCAAACATCCATTTTCTTTGTGAACATATTAGTGATTGAAGTATTTTGACTTTTGAGATTGAATGTAAAATATTTTAAATTTG
GGATCATCGCCTGTTCTGAAAACTAGATGCACCAACCGTATCATTATTTGTTTGAGGAAAAAAAGAAATCTGCATTTTAATTCATGTTGG
TCAAAGTCGAATTACTATCTATTTATCTTATATCGTAGATCTGATAACCCTATCTAAAAGAAAGTCACACGCTAAATGTATTCTTACATA
GTGCTTGTATCGTTGCATTTGTTTTAATTTGTGGAAAAGTATTGTATCTAACTTGTATTACTTTGGTAGTTTCATCTTTATGTATTATTG
ATATTTGTAATTTTCTCAACTATAACAATGTAGTTACGCTACAACTTGCCTAAAACATTCAAACTTGTTTTCTTTTTTCTGTTTTTTTCT
TTGTTAATTCATTTAAACTCATTGAAAACATAGTATACATTACTAAAAGGTAAATTATGGGAATCACTGAAATATTTTTGTAGATTAATT
GTTGTAACATTGTCTTTCTTTTTTTTCTTTTGTTTCATGATTTTGATTTTTAAAATTATTAGCACACAACTATTTTCAGCCCTTTAATAA
TGGAGCATCAAAAACATCACCTGTAACCCCAAGCAAATATAGAAGACTGTATTTTTTACTATGATATCCATTTTCCAGAATTGTGATTAC
AATATGCAAAGAGTCATAAATATGCCATTTACAATAAGGAGGAGGCAAGGCAAATGCATAGATGTACAAATATATGTACAACAGATTTTG
CTTTTTATTTATTTATAATGTAATTTTATAGAATAATTCTGGGATTTGAGAGGATCTAAAACTATTTTTCTGTATAAATATTATTTGCCA
AAAGTTTGTTTATATTCAGAAGTCTGACTATGATGAATAAATCTTAAATGCTTTGTTTAATTAAAAAACAAAAATCACCAATATCCAAGA
CATGAAGATATCAGTTCAACAAATACTGTAGTTAAGAGACTAACTCTCCACTTGTATGGGAACTACATTTCACTCTTGGTTTTCAGGATA
TAACAGCACTTCACCGAAATATTCTTTCAGCCATACCACTGGTAACATTTCTACTAAATCTTTCTGTAACACTTAAAGAATTCCCTCATT
CATTACCTTACAGTGTAAACAGGAGTCTAATTTGTATCAATACTATGTTTTGGTTGTAATATTCAGTTCACTCACCCAATGTACAACCAA

>51408_51408_1_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000302217_MBNL2_chr13_98043576_ENST00000343600_length(amino acids)=74AA_BP=

--------------------------------------------------------------
>51408_51408_2_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000302217_MBNL2_chr13_98043576_ENST00000345429_length(transcript)=2996nt_BP=197nt
CTGGTCTGCGGCTGAGATACACAGAGCGACAGAGACATTTATTGTTATTTGTTTTTTGGTGGCAAAAAGGGAAAATGGCGAACGACTCCC
CTGCAAAAAGTCTGGTGGACATCGACCTCTCCTCCCTGCGGGATCCTGCTGGGATTTTTGAGCTGGTGGAAGTGGTTGGAAATGGCACCT
ATGGACAAGTCTATAAGATAATTCTGAAATAATCAGCAGAAACGGAATGGAATGCCAAGAATCTGCATTGAGAATAACTAAACATTGTTA
CTGTACATACTATCCTGTTTCCTCCTCAATAGAATTGCCACAAACTGCATGCTAAATAAAGATGTAGTTCTTCTGGACAGACCACAACTC
TAAGAAGCTAGTGCTGCTATCTCATATATGAGTATTAAATATGGTATGCTTAGTATATTCCAACCTAAGATAGTTAACTACCTGAGACCA
GCTGTGATGTTTAAAGACATAAAGGATAAAGTTTACTTTTAAAGGGTTTCTAAACATAGTTTCTGTCCTAGGAATATTGTCTTATCTCCA
TAACTATAGCTGATGCAGAAAGTCCAGCCAGTTTACTCATTTCGATTCAGAATATTTCAAATTTAGCAATAAACAATTAGCATTAGTTAA
AAAAGAAACATATTCCAAGGGCAGGTTCGATTCTAGCTCTAATTACTGTCATGTCATTTACCCACTGGATCAAAGGGTATGTTTCACTTC
TTGACAATATAAATGCTGCAGCAAAGATGAGAGGTGAAGTAAAACCGATACCTGTCCTGCAGGTCTAAAATTTGAATGGAAATTCAAGCA
CAAGTACTGGGGACACATCAAAGTGTGGTGTTTGGTTTGCCTGGAGATGCCACGTTGAATCATGTGATTCTAGATTAACATTAAATAGAT
TGAAAAAGAAACTTTGCACGGTATGAGCTTCATACCCCACCAAACAAAGTCTTGAAGGTATTATTTTACAAGTATATTTTTAAAGTTGTT
TTATAAGAGAGACTTTGTAGAAGTGCCTAGATTTTGCCAGACTTCATCCAGCTTGACAAGATTGAGAGGCCCATGCCAACAGTCTAATCT
AAGAGATTAGTCTTTCAAACTCACCATCCAGTTGCCTGTTACAGAATAACTCTTCTTAACTAAAAACCTAGTCAAACAAGGAAGCTGTAG
GTGAGGAGATCTGTATAATATTCTAATTTAAGTAAGTTTGAGTTTAGTCACTGCAAATTTGACTGTGACTTTAATCTAAATTACTATGTA
AACAAAAAGTAGATAGTTTCACTTTTTAAAAAATCCATTACTGTTTTGCATTTCAAAAGTTGGATTAAAGGGTTGTAACTGACTACAGCA
TGGAAAAAAATAGTTCTTTTAATTCTTTCACCTTAAAGCATATTTTATGTCTCAAAAGTATAAAAAACTTTAATACAAGTACATACATAT
TATATATACACATACATATATATACTATATATGGATGAAACATATTTTAATGTTGTTTACTTTTTTAAATACTTGGTTGATCTTCAAGGT
AATAGCGATACAATTAAATTTTGTTCAGAAAGTTTGTTTTAAAGTTTATTTTAAGCACTATCGTACCAAATATTTCATATTTCACATTTT
ATATGTTGCACATAGCCTATACAGTACCTACATAGTTTTTAAATTATTGTTTAAAAAACAAAACAGCTGTTATAAATGAATATTATGTGT
AATTGTTTCAAACATCCATTTTCTTTGTGAACATATTAGTGATTGAAGTATTTTGACTTTTGAGATTGAATGTAAAATATTTTAAATTTG
GGATCATCGCCTGTTCTGAAAACTAGATGCACCAACCGTATCATTATTTGTTTGAGGAAAAAAAGAAATCTGCATTTTAATTCATGTTGG
TCAAAGTCGAATTACTATCTATTTATCTTATATCGTAGATCTGATAACCCTATCTAAAAGAAAGTCACACGCTAAATGTATTCTTACATA
GTGCTTGTATCGTTGCATTTGTTTTAATTTGTGGAAAAGTATTGTATCTAACTTGTATTACTTTGGTAGTTTCATCTTTATGTATTATTG
ATATTTGTAATTTTCTCAACTATAACAATGTAGTTACGCTACAACTTGCCTAAAACATTCAAACTTGTTTTCTTTTTTCTGTTTTTTTCT
TTGTTAATTCATTTAAACTCATTGAAAACATAGTATACATTACTAAAAGGTAAATTATGGGAATCACTGAAATATTTTTGTAGATTAATT
GTTGTAACATTGTCTTTCTTTTTTTTCTTTTGTTTCATGATTTTGATTTTTAAAATTATTAGCACACAACTATTTTCAGCCCTTTAATAA
TGGAGCATCAAAAACATCACCTGTAACCCCAAGCAAATATAGAAGACTGTATTTTTTACTATGATATCCATTTTCCAGAATTGTGATTAC
AATATGCAAAGAGTCATAAATATGCCATTTACAATAAGGAGGAGGCAAGGCAAATGCATAGATGTACAAATATATGTACAACAGATTTTG
CTTTTTATTTATTTATAATGTAATTTTATAGAATAATTCTGGGATTTGAGAGGATCTAAAACTATTTTTCTGTATAAATATTATTTGCCA
AAAGTTTGTTTATATTCAGAAGTCTGACTATGATGAATAAATCTTAAATGCTTTGTTTAATTAAAAAACAAAAATCACCAATATCCAAGA
CATGAAGATATCAGTTCAACAAATACTGTAGTTAAGAGACTAACTCTCCACTTGTATGGGAACTACATTTCACTCTTGGTTTTCAGGATA
TAACAGCACTTCACCGAAATATTCTTTCAGCCATACCACTGGTAACATTTCTACTAAATCTTTCTGTAACACTTAAAGAATTCCCTCATT
CATTACCTTACAGTGTAAACAGGAGTCTAATTTGTATCAATACTATGTTTTGGTTGTAATATTCAGTTCACTCACCCAATGTACAACCAA

>51408_51408_2_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000302217_MBNL2_chr13_98043576_ENST00000345429_length(amino acids)=74AA_BP=

--------------------------------------------------------------
>51408_51408_3_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000324219_MBNL2_chr13_98043576_ENST00000343600_length(transcript)=2995nt_BP=197nt
CTGGTCTGCGGCTGAGATACACAGAGCGACAGAGACATTTATTGTTATTTGTTTTTTGGTGGCAAAAAGGGAAAATGGCGAACGACTCCC
CTGCAAAAAGTCTGGTGGACATCGACCTCTCCTCCCTGCGGGATCCTGCTGGGATTTTTGAGCTGGTGGAAGTGGTTGGAAATGGCACCT
ATGGACAAGTCTATAAGATAATTCTGAAATAATCAGCAGAAACGGAATGGAATGCCAAGAATCTGCATTGAGAATAACTAAACATTGTTA
CTGTACATACTATCCTGTTTCCTCCTCAATAGAATTGCCACAAACTGCATGCTAAATAAAGATGTAGTTCTTCTGGACAGACCACAACTC
TAAGAAGCTAGTGCTGCTATCTCATATATGAGTATTAAATATGGTATGCTTAGTATATTCCAACCTAAGATAGTTAACTACCTGAGACCA
GCTGTGATGTTTAAAGACATAAAGGATAAAGTTTACTTTTAAAGGGTTTCTAAACATAGTTTCTGTCCTAGGAATATTGTCTTATCTCCA
TAACTATAGCTGATGCAGAAAGTCCAGCCAGTTTACTCATTTCGATTCAGAATATTTCAAATTTAGCAATAAACAATTAGCATTAGTTAA
AAAAGAAACATATTCCAAGGGCAGGTTCGATTCTAGCTCTAATTACTGTCATGTCATTTACCCACTGGATCAAAGGGTATGTTTCACTTC
TTGACAATATAAATGCTGCAGCAAAGATGAGAGGTGAAGTAAAACCGATACCTGTCCTGCAGGTCTAAAATTTGAATGGAAATTCAAGCA
CAAGTACTGGGGACACATCAAAGTGTGGTGTTTGGTTTGCCTGGAGATGCCACGTTGAATCATGTGATTCTAGATTAACATTAAATAGAT
TGAAAAAGAAACTTTGCACGGTATGAGCTTCATACCCCACCAAACAAAGTCTTGAAGGTATTATTTTACAAGTATATTTTTAAAGTTGTT
TTATAAGAGAGACTTTGTAGAAGTGCCTAGATTTTGCCAGACTTCATCCAGCTTGACAAGATTGAGAGGCCCATGCCAACAGTCTAATCT
AAGAGATTAGTCTTTCAAACTCACCATCCAGTTGCCTGTTACAGAATAACTCTTCTTAACTAAAAACCTAGTCAAACAAGGAAGCTGTAG
GTGAGGAGATCTGTATAATATTCTAATTTAAGTAAGTTTGAGTTTAGTCACTGCAAATTTGACTGTGACTTTAATCTAAATTACTATGTA
AACAAAAAGTAGATAGTTTCACTTTTTAAAAAATCCATTACTGTTTTGCATTTCAAAAGTTGGATTAAAGGGTTGTAACTGACTACAGCA
TGGAAAAAAATAGTTCTTTTAATTCTTTCACCTTAAAGCATATTTTATGTCTCAAAAGTATAAAAAACTTTAATACAAGTACATACATAT
TATATATACACATACATATATATACTATATATGGATGAAACATATTTTAATGTTGTTTACTTTTTTAAATACTTGGTTGATCTTCAAGGT
AATAGCGATACAATTAAATTTTGTTCAGAAAGTTTGTTTTAAAGTTTATTTTAAGCACTATCGTACCAAATATTTCATATTTCACATTTT
ATATGTTGCACATAGCCTATACAGTACCTACATAGTTTTTAAATTATTGTTTAAAAAACAAAACAGCTGTTATAAATGAATATTATGTGT
AATTGTTTCAAACATCCATTTTCTTTGTGAACATATTAGTGATTGAAGTATTTTGACTTTTGAGATTGAATGTAAAATATTTTAAATTTG
GGATCATCGCCTGTTCTGAAAACTAGATGCACCAACCGTATCATTATTTGTTTGAGGAAAAAAAGAAATCTGCATTTTAATTCATGTTGG
TCAAAGTCGAATTACTATCTATTTATCTTATATCGTAGATCTGATAACCCTATCTAAAAGAAAGTCACACGCTAAATGTATTCTTACATA
GTGCTTGTATCGTTGCATTTGTTTTAATTTGTGGAAAAGTATTGTATCTAACTTGTATTACTTTGGTAGTTTCATCTTTATGTATTATTG
ATATTTGTAATTTTCTCAACTATAACAATGTAGTTACGCTACAACTTGCCTAAAACATTCAAACTTGTTTTCTTTTTTCTGTTTTTTTCT
TTGTTAATTCATTTAAACTCATTGAAAACATAGTATACATTACTAAAAGGTAAATTATGGGAATCACTGAAATATTTTTGTAGATTAATT
GTTGTAACATTGTCTTTCTTTTTTTTCTTTTGTTTCATGATTTTGATTTTTAAAATTATTAGCACACAACTATTTTCAGCCCTTTAATAA
TGGAGCATCAAAAACATCACCTGTAACCCCAAGCAAATATAGAAGACTGTATTTTTTACTATGATATCCATTTTCCAGAATTGTGATTAC
AATATGCAAAGAGTCATAAATATGCCATTTACAATAAGGAGGAGGCAAGGCAAATGCATAGATGTACAAATATATGTACAACAGATTTTG
CTTTTTATTTATTTATAATGTAATTTTATAGAATAATTCTGGGATTTGAGAGGATCTAAAACTATTTTTCTGTATAAATATTATTTGCCA
AAAGTTTGTTTATATTCAGAAGTCTGACTATGATGAATAAATCTTAAATGCTTTGTTTAATTAAAAAACAAAAATCACCAATATCCAAGA
CATGAAGATATCAGTTCAACAAATACTGTAGTTAAGAGACTAACTCTCCACTTGTATGGGAACTACATTTCACTCTTGGTTTTCAGGATA
TAACAGCACTTCACCGAAATATTCTTTCAGCCATACCACTGGTAACATTTCTACTAAATCTTTCTGTAACACTTAAAGAATTCCCTCATT
CATTACCTTACAGTGTAAACAGGAGTCTAATTTGTATCAATACTATGTTTTGGTTGTAATATTCAGTTCACTCACCCAATGTACAACCAA

>51408_51408_3_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000324219_MBNL2_chr13_98043576_ENST00000343600_length(amino acids)=74AA_BP=

--------------------------------------------------------------
>51408_51408_4_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000324219_MBNL2_chr13_98043576_ENST00000345429_length(transcript)=2996nt_BP=197nt
CTGGTCTGCGGCTGAGATACACAGAGCGACAGAGACATTTATTGTTATTTGTTTTTTGGTGGCAAAAAGGGAAAATGGCGAACGACTCCC
CTGCAAAAAGTCTGGTGGACATCGACCTCTCCTCCCTGCGGGATCCTGCTGGGATTTTTGAGCTGGTGGAAGTGGTTGGAAATGGCACCT
ATGGACAAGTCTATAAGATAATTCTGAAATAATCAGCAGAAACGGAATGGAATGCCAAGAATCTGCATTGAGAATAACTAAACATTGTTA
CTGTACATACTATCCTGTTTCCTCCTCAATAGAATTGCCACAAACTGCATGCTAAATAAAGATGTAGTTCTTCTGGACAGACCACAACTC
TAAGAAGCTAGTGCTGCTATCTCATATATGAGTATTAAATATGGTATGCTTAGTATATTCCAACCTAAGATAGTTAACTACCTGAGACCA
GCTGTGATGTTTAAAGACATAAAGGATAAAGTTTACTTTTAAAGGGTTTCTAAACATAGTTTCTGTCCTAGGAATATTGTCTTATCTCCA
TAACTATAGCTGATGCAGAAAGTCCAGCCAGTTTACTCATTTCGATTCAGAATATTTCAAATTTAGCAATAAACAATTAGCATTAGTTAA
AAAAGAAACATATTCCAAGGGCAGGTTCGATTCTAGCTCTAATTACTGTCATGTCATTTACCCACTGGATCAAAGGGTATGTTTCACTTC
TTGACAATATAAATGCTGCAGCAAAGATGAGAGGTGAAGTAAAACCGATACCTGTCCTGCAGGTCTAAAATTTGAATGGAAATTCAAGCA
CAAGTACTGGGGACACATCAAAGTGTGGTGTTTGGTTTGCCTGGAGATGCCACGTTGAATCATGTGATTCTAGATTAACATTAAATAGAT
TGAAAAAGAAACTTTGCACGGTATGAGCTTCATACCCCACCAAACAAAGTCTTGAAGGTATTATTTTACAAGTATATTTTTAAAGTTGTT
TTATAAGAGAGACTTTGTAGAAGTGCCTAGATTTTGCCAGACTTCATCCAGCTTGACAAGATTGAGAGGCCCATGCCAACAGTCTAATCT
AAGAGATTAGTCTTTCAAACTCACCATCCAGTTGCCTGTTACAGAATAACTCTTCTTAACTAAAAACCTAGTCAAACAAGGAAGCTGTAG
GTGAGGAGATCTGTATAATATTCTAATTTAAGTAAGTTTGAGTTTAGTCACTGCAAATTTGACTGTGACTTTAATCTAAATTACTATGTA
AACAAAAAGTAGATAGTTTCACTTTTTAAAAAATCCATTACTGTTTTGCATTTCAAAAGTTGGATTAAAGGGTTGTAACTGACTACAGCA
TGGAAAAAAATAGTTCTTTTAATTCTTTCACCTTAAAGCATATTTTATGTCTCAAAAGTATAAAAAACTTTAATACAAGTACATACATAT
TATATATACACATACATATATATACTATATATGGATGAAACATATTTTAATGTTGTTTACTTTTTTAAATACTTGGTTGATCTTCAAGGT
AATAGCGATACAATTAAATTTTGTTCAGAAAGTTTGTTTTAAAGTTTATTTTAAGCACTATCGTACCAAATATTTCATATTTCACATTTT
ATATGTTGCACATAGCCTATACAGTACCTACATAGTTTTTAAATTATTGTTTAAAAAACAAAACAGCTGTTATAAATGAATATTATGTGT
AATTGTTTCAAACATCCATTTTCTTTGTGAACATATTAGTGATTGAAGTATTTTGACTTTTGAGATTGAATGTAAAATATTTTAAATTTG
GGATCATCGCCTGTTCTGAAAACTAGATGCACCAACCGTATCATTATTTGTTTGAGGAAAAAAAGAAATCTGCATTTTAATTCATGTTGG
TCAAAGTCGAATTACTATCTATTTATCTTATATCGTAGATCTGATAACCCTATCTAAAAGAAAGTCACACGCTAAATGTATTCTTACATA
GTGCTTGTATCGTTGCATTTGTTTTAATTTGTGGAAAAGTATTGTATCTAACTTGTATTACTTTGGTAGTTTCATCTTTATGTATTATTG
ATATTTGTAATTTTCTCAACTATAACAATGTAGTTACGCTACAACTTGCCTAAAACATTCAAACTTGTTTTCTTTTTTCTGTTTTTTTCT
TTGTTAATTCATTTAAACTCATTGAAAACATAGTATACATTACTAAAAGGTAAATTATGGGAATCACTGAAATATTTTTGTAGATTAATT
GTTGTAACATTGTCTTTCTTTTTTTTCTTTTGTTTCATGATTTTGATTTTTAAAATTATTAGCACACAACTATTTTCAGCCCTTTAATAA
TGGAGCATCAAAAACATCACCTGTAACCCCAAGCAAATATAGAAGACTGTATTTTTTACTATGATATCCATTTTCCAGAATTGTGATTAC
AATATGCAAAGAGTCATAAATATGCCATTTACAATAAGGAGGAGGCAAGGCAAATGCATAGATGTACAAATATATGTACAACAGATTTTG
CTTTTTATTTATTTATAATGTAATTTTATAGAATAATTCTGGGATTTGAGAGGATCTAAAACTATTTTTCTGTATAAATATTATTTGCCA
AAAGTTTGTTTATATTCAGAAGTCTGACTATGATGAATAAATCTTAAATGCTTTGTTTAATTAAAAAACAAAAATCACCAATATCCAAGA
CATGAAGATATCAGTTCAACAAATACTGTAGTTAAGAGACTAACTCTCCACTTGTATGGGAACTACATTTCACTCTTGGTTTTCAGGATA
TAACAGCACTTCACCGAAATATTCTTTCAGCCATACCACTGGTAACATTTCTACTAAATCTTTCTGTAACACTTAAAGAATTCCCTCATT
CATTACCTTACAGTGTAAACAGGAGTCTAATTTGTATCAATACTATGTTTTGGTTGTAATATTCAGTTCACTCACCCAATGTACAACCAA

>51408_51408_4_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000324219_MBNL2_chr13_98043576_ENST00000345429_length(amino acids)=74AA_BP=

--------------------------------------------------------------
>51408_51408_5_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000347699_MBNL2_chr13_98043576_ENST00000343600_length(transcript)=2921nt_BP=123nt
ATGGCGAACGACTCCCCTGCAAAAAGTCTGGTGGACATCGACCTCTCCTCCCTGCGGGATCCTGCTGGGATTTTTGAGCTGGTGGAAGTG
GTTGGAAATGGCACCTATGGACAAGTCTATAAGATAATTCTGAAATAATCAGCAGAAACGGAATGGAATGCCAAGAATCTGCATTGAGAA
TAACTAAACATTGTTACTGTACATACTATCCTGTTTCCTCCTCAATAGAATTGCCACAAACTGCATGCTAAATAAAGATGTAGTTCTTCT
GGACAGACCACAACTCTAAGAAGCTAGTGCTGCTATCTCATATATGAGTATTAAATATGGTATGCTTAGTATATTCCAACCTAAGATAGT
TAACTACCTGAGACCAGCTGTGATGTTTAAAGACATAAAGGATAAAGTTTACTTTTAAAGGGTTTCTAAACATAGTTTCTGTCCTAGGAA
TATTGTCTTATCTCCATAACTATAGCTGATGCAGAAAGTCCAGCCAGTTTACTCATTTCGATTCAGAATATTTCAAATTTAGCAATAAAC
AATTAGCATTAGTTAAAAAAGAAACATATTCCAAGGGCAGGTTCGATTCTAGCTCTAATTACTGTCATGTCATTTACCCACTGGATCAAA
GGGTATGTTTCACTTCTTGACAATATAAATGCTGCAGCAAAGATGAGAGGTGAAGTAAAACCGATACCTGTCCTGCAGGTCTAAAATTTG
AATGGAAATTCAAGCACAAGTACTGGGGACACATCAAAGTGTGGTGTTTGGTTTGCCTGGAGATGCCACGTTGAATCATGTGATTCTAGA
TTAACATTAAATAGATTGAAAAAGAAACTTTGCACGGTATGAGCTTCATACCCCACCAAACAAAGTCTTGAAGGTATTATTTTACAAGTA
TATTTTTAAAGTTGTTTTATAAGAGAGACTTTGTAGAAGTGCCTAGATTTTGCCAGACTTCATCCAGCTTGACAAGATTGAGAGGCCCAT
GCCAACAGTCTAATCTAAGAGATTAGTCTTTCAAACTCACCATCCAGTTGCCTGTTACAGAATAACTCTTCTTAACTAAAAACCTAGTCA
AACAAGGAAGCTGTAGGTGAGGAGATCTGTATAATATTCTAATTTAAGTAAGTTTGAGTTTAGTCACTGCAAATTTGACTGTGACTTTAA
TCTAAATTACTATGTAAACAAAAAGTAGATAGTTTCACTTTTTAAAAAATCCATTACTGTTTTGCATTTCAAAAGTTGGATTAAAGGGTT
GTAACTGACTACAGCATGGAAAAAAATAGTTCTTTTAATTCTTTCACCTTAAAGCATATTTTATGTCTCAAAAGTATAAAAAACTTTAAT
ACAAGTACATACATATTATATATACACATACATATATATACTATATATGGATGAAACATATTTTAATGTTGTTTACTTTTTTAAATACTT
GGTTGATCTTCAAGGTAATAGCGATACAATTAAATTTTGTTCAGAAAGTTTGTTTTAAAGTTTATTTTAAGCACTATCGTACCAAATATT
TCATATTTCACATTTTATATGTTGCACATAGCCTATACAGTACCTACATAGTTTTTAAATTATTGTTTAAAAAACAAAACAGCTGTTATA
AATGAATATTATGTGTAATTGTTTCAAACATCCATTTTCTTTGTGAACATATTAGTGATTGAAGTATTTTGACTTTTGAGATTGAATGTA
AAATATTTTAAATTTGGGATCATCGCCTGTTCTGAAAACTAGATGCACCAACCGTATCATTATTTGTTTGAGGAAAAAAAGAAATCTGCA
TTTTAATTCATGTTGGTCAAAGTCGAATTACTATCTATTTATCTTATATCGTAGATCTGATAACCCTATCTAAAAGAAAGTCACACGCTA
AATGTATTCTTACATAGTGCTTGTATCGTTGCATTTGTTTTAATTTGTGGAAAAGTATTGTATCTAACTTGTATTACTTTGGTAGTTTCA
TCTTTATGTATTATTGATATTTGTAATTTTCTCAACTATAACAATGTAGTTACGCTACAACTTGCCTAAAACATTCAAACTTGTTTTCTT
TTTTCTGTTTTTTTCTTTGTTAATTCATTTAAACTCATTGAAAACATAGTATACATTACTAAAAGGTAAATTATGGGAATCACTGAAATA
TTTTTGTAGATTAATTGTTGTAACATTGTCTTTCTTTTTTTTCTTTTGTTTCATGATTTTGATTTTTAAAATTATTAGCACACAACTATT
TTCAGCCCTTTAATAATGGAGCATCAAAAACATCACCTGTAACCCCAAGCAAATATAGAAGACTGTATTTTTTACTATGATATCCATTTT
CCAGAATTGTGATTACAATATGCAAAGAGTCATAAATATGCCATTTACAATAAGGAGGAGGCAAGGCAAATGCATAGATGTACAAATATA
TGTACAACAGATTTTGCTTTTTATTTATTTATAATGTAATTTTATAGAATAATTCTGGGATTTGAGAGGATCTAAAACTATTTTTCTGTA
TAAATATTATTTGCCAAAAGTTTGTTTATATTCAGAAGTCTGACTATGATGAATAAATCTTAAATGCTTTGTTTAATTAAAAAACAAAAA
TCACCAATATCCAAGACATGAAGATATCAGTTCAACAAATACTGTAGTTAAGAGACTAACTCTCCACTTGTATGGGAACTACATTTCACT
CTTGGTTTTCAGGATATAACAGCACTTCACCGAAATATTCTTTCAGCCATACCACTGGTAACATTTCTACTAAATCTTTCTGTAACACTT
AAAGAATTCCCTCATTCATTACCTTACAGTGTAAACAGGAGTCTAATTTGTATCAATACTATGTTTTGGTTGTAATATTCAGTTCACTCA

>51408_51408_5_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000347699_MBNL2_chr13_98043576_ENST00000343600_length(amino acids)=74AA_BP=

--------------------------------------------------------------
>51408_51408_6_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000347699_MBNL2_chr13_98043576_ENST00000345429_length(transcript)=2922nt_BP=123nt
ATGGCGAACGACTCCCCTGCAAAAAGTCTGGTGGACATCGACCTCTCCTCCCTGCGGGATCCTGCTGGGATTTTTGAGCTGGTGGAAGTG
GTTGGAAATGGCACCTATGGACAAGTCTATAAGATAATTCTGAAATAATCAGCAGAAACGGAATGGAATGCCAAGAATCTGCATTGAGAA
TAACTAAACATTGTTACTGTACATACTATCCTGTTTCCTCCTCAATAGAATTGCCACAAACTGCATGCTAAATAAAGATGTAGTTCTTCT
GGACAGACCACAACTCTAAGAAGCTAGTGCTGCTATCTCATATATGAGTATTAAATATGGTATGCTTAGTATATTCCAACCTAAGATAGT
TAACTACCTGAGACCAGCTGTGATGTTTAAAGACATAAAGGATAAAGTTTACTTTTAAAGGGTTTCTAAACATAGTTTCTGTCCTAGGAA
TATTGTCTTATCTCCATAACTATAGCTGATGCAGAAAGTCCAGCCAGTTTACTCATTTCGATTCAGAATATTTCAAATTTAGCAATAAAC
AATTAGCATTAGTTAAAAAAGAAACATATTCCAAGGGCAGGTTCGATTCTAGCTCTAATTACTGTCATGTCATTTACCCACTGGATCAAA
GGGTATGTTTCACTTCTTGACAATATAAATGCTGCAGCAAAGATGAGAGGTGAAGTAAAACCGATACCTGTCCTGCAGGTCTAAAATTTG
AATGGAAATTCAAGCACAAGTACTGGGGACACATCAAAGTGTGGTGTTTGGTTTGCCTGGAGATGCCACGTTGAATCATGTGATTCTAGA
TTAACATTAAATAGATTGAAAAAGAAACTTTGCACGGTATGAGCTTCATACCCCACCAAACAAAGTCTTGAAGGTATTATTTTACAAGTA
TATTTTTAAAGTTGTTTTATAAGAGAGACTTTGTAGAAGTGCCTAGATTTTGCCAGACTTCATCCAGCTTGACAAGATTGAGAGGCCCAT
GCCAACAGTCTAATCTAAGAGATTAGTCTTTCAAACTCACCATCCAGTTGCCTGTTACAGAATAACTCTTCTTAACTAAAAACCTAGTCA
AACAAGGAAGCTGTAGGTGAGGAGATCTGTATAATATTCTAATTTAAGTAAGTTTGAGTTTAGTCACTGCAAATTTGACTGTGACTTTAA
TCTAAATTACTATGTAAACAAAAAGTAGATAGTTTCACTTTTTAAAAAATCCATTACTGTTTTGCATTTCAAAAGTTGGATTAAAGGGTT
GTAACTGACTACAGCATGGAAAAAAATAGTTCTTTTAATTCTTTCACCTTAAAGCATATTTTATGTCTCAAAAGTATAAAAAACTTTAAT
ACAAGTACATACATATTATATATACACATACATATATATACTATATATGGATGAAACATATTTTAATGTTGTTTACTTTTTTAAATACTT
GGTTGATCTTCAAGGTAATAGCGATACAATTAAATTTTGTTCAGAAAGTTTGTTTTAAAGTTTATTTTAAGCACTATCGTACCAAATATT
TCATATTTCACATTTTATATGTTGCACATAGCCTATACAGTACCTACATAGTTTTTAAATTATTGTTTAAAAAACAAAACAGCTGTTATA
AATGAATATTATGTGTAATTGTTTCAAACATCCATTTTCTTTGTGAACATATTAGTGATTGAAGTATTTTGACTTTTGAGATTGAATGTA
AAATATTTTAAATTTGGGATCATCGCCTGTTCTGAAAACTAGATGCACCAACCGTATCATTATTTGTTTGAGGAAAAAAAGAAATCTGCA
TTTTAATTCATGTTGGTCAAAGTCGAATTACTATCTATTTATCTTATATCGTAGATCTGATAACCCTATCTAAAAGAAAGTCACACGCTA
AATGTATTCTTACATAGTGCTTGTATCGTTGCATTTGTTTTAATTTGTGGAAAAGTATTGTATCTAACTTGTATTACTTTGGTAGTTTCA
TCTTTATGTATTATTGATATTTGTAATTTTCTCAACTATAACAATGTAGTTACGCTACAACTTGCCTAAAACATTCAAACTTGTTTTCTT
TTTTCTGTTTTTTTCTTTGTTAATTCATTTAAACTCATTGAAAACATAGTATACATTACTAAAAGGTAAATTATGGGAATCACTGAAATA
TTTTTGTAGATTAATTGTTGTAACATTGTCTTTCTTTTTTTTCTTTTGTTTCATGATTTTGATTTTTAAAATTATTAGCACACAACTATT
TTCAGCCCTTTAATAATGGAGCATCAAAAACATCACCTGTAACCCCAAGCAAATATAGAAGACTGTATTTTTTACTATGATATCCATTTT
CCAGAATTGTGATTACAATATGCAAAGAGTCATAAATATGCCATTTACAATAAGGAGGAGGCAAGGCAAATGCATAGATGTACAAATATA
TGTACAACAGATTTTGCTTTTTATTTATTTATAATGTAATTTTATAGAATAATTCTGGGATTTGAGAGGATCTAAAACTATTTTTCTGTA
TAAATATTATTTGCCAAAAGTTTGTTTATATTCAGAAGTCTGACTATGATGAATAAATCTTAAATGCTTTGTTTAATTAAAAAACAAAAA
TCACCAATATCCAAGACATGAAGATATCAGTTCAACAAATACTGTAGTTAAGAGACTAACTCTCCACTTGTATGGGAACTACATTTCACT
CTTGGTTTTCAGGATATAACAGCACTTCACCGAAATATTCTTTCAGCCATACCACTGGTAACATTTCTACTAAATCTTTCTGTAACACTT
AAAGAATTCCCTCATTCATTACCTTACAGTGTAAACAGGAGTCTAATTTGTATCAATACTATGTTTTGGTTGTAATATTCAGTTCACTCA

>51408_51408_6_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000347699_MBNL2_chr13_98043576_ENST00000345429_length(amino acids)=74AA_BP=

--------------------------------------------------------------
>51408_51408_7_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000350198_MBNL2_chr13_98043576_ENST00000343600_length(transcript)=2995nt_BP=197nt
CTGGTCTGCGGCTGAGATACACAGAGCGACAGAGACATTTATTGTTATTTGTTTTTTGGTGGCAAAAAGGGAAAATGGCGAACGACTCCC
CTGCAAAAAGTCTGGTGGACATCGACCTCTCCTCCCTGCGGGATCCTGCTGGGATTTTTGAGCTGGTGGAAGTGGTTGGAAATGGCACCT
ATGGACAAGTCTATAAGATAATTCTGAAATAATCAGCAGAAACGGAATGGAATGCCAAGAATCTGCATTGAGAATAACTAAACATTGTTA
CTGTACATACTATCCTGTTTCCTCCTCAATAGAATTGCCACAAACTGCATGCTAAATAAAGATGTAGTTCTTCTGGACAGACCACAACTC
TAAGAAGCTAGTGCTGCTATCTCATATATGAGTATTAAATATGGTATGCTTAGTATATTCCAACCTAAGATAGTTAACTACCTGAGACCA
GCTGTGATGTTTAAAGACATAAAGGATAAAGTTTACTTTTAAAGGGTTTCTAAACATAGTTTCTGTCCTAGGAATATTGTCTTATCTCCA
TAACTATAGCTGATGCAGAAAGTCCAGCCAGTTTACTCATTTCGATTCAGAATATTTCAAATTTAGCAATAAACAATTAGCATTAGTTAA
AAAAGAAACATATTCCAAGGGCAGGTTCGATTCTAGCTCTAATTACTGTCATGTCATTTACCCACTGGATCAAAGGGTATGTTTCACTTC
TTGACAATATAAATGCTGCAGCAAAGATGAGAGGTGAAGTAAAACCGATACCTGTCCTGCAGGTCTAAAATTTGAATGGAAATTCAAGCA
CAAGTACTGGGGACACATCAAAGTGTGGTGTTTGGTTTGCCTGGAGATGCCACGTTGAATCATGTGATTCTAGATTAACATTAAATAGAT
TGAAAAAGAAACTTTGCACGGTATGAGCTTCATACCCCACCAAACAAAGTCTTGAAGGTATTATTTTACAAGTATATTTTTAAAGTTGTT
TTATAAGAGAGACTTTGTAGAAGTGCCTAGATTTTGCCAGACTTCATCCAGCTTGACAAGATTGAGAGGCCCATGCCAACAGTCTAATCT
AAGAGATTAGTCTTTCAAACTCACCATCCAGTTGCCTGTTACAGAATAACTCTTCTTAACTAAAAACCTAGTCAAACAAGGAAGCTGTAG
GTGAGGAGATCTGTATAATATTCTAATTTAAGTAAGTTTGAGTTTAGTCACTGCAAATTTGACTGTGACTTTAATCTAAATTACTATGTA
AACAAAAAGTAGATAGTTTCACTTTTTAAAAAATCCATTACTGTTTTGCATTTCAAAAGTTGGATTAAAGGGTTGTAACTGACTACAGCA
TGGAAAAAAATAGTTCTTTTAATTCTTTCACCTTAAAGCATATTTTATGTCTCAAAAGTATAAAAAACTTTAATACAAGTACATACATAT
TATATATACACATACATATATATACTATATATGGATGAAACATATTTTAATGTTGTTTACTTTTTTAAATACTTGGTTGATCTTCAAGGT
AATAGCGATACAATTAAATTTTGTTCAGAAAGTTTGTTTTAAAGTTTATTTTAAGCACTATCGTACCAAATATTTCATATTTCACATTTT
ATATGTTGCACATAGCCTATACAGTACCTACATAGTTTTTAAATTATTGTTTAAAAAACAAAACAGCTGTTATAAATGAATATTATGTGT
AATTGTTTCAAACATCCATTTTCTTTGTGAACATATTAGTGATTGAAGTATTTTGACTTTTGAGATTGAATGTAAAATATTTTAAATTTG
GGATCATCGCCTGTTCTGAAAACTAGATGCACCAACCGTATCATTATTTGTTTGAGGAAAAAAAGAAATCTGCATTTTAATTCATGTTGG
TCAAAGTCGAATTACTATCTATTTATCTTATATCGTAGATCTGATAACCCTATCTAAAAGAAAGTCACACGCTAAATGTATTCTTACATA
GTGCTTGTATCGTTGCATTTGTTTTAATTTGTGGAAAAGTATTGTATCTAACTTGTATTACTTTGGTAGTTTCATCTTTATGTATTATTG
ATATTTGTAATTTTCTCAACTATAACAATGTAGTTACGCTACAACTTGCCTAAAACATTCAAACTTGTTTTCTTTTTTCTGTTTTTTTCT
TTGTTAATTCATTTAAACTCATTGAAAACATAGTATACATTACTAAAAGGTAAATTATGGGAATCACTGAAATATTTTTGTAGATTAATT
GTTGTAACATTGTCTTTCTTTTTTTTCTTTTGTTTCATGATTTTGATTTTTAAAATTATTAGCACACAACTATTTTCAGCCCTTTAATAA
TGGAGCATCAAAAACATCACCTGTAACCCCAAGCAAATATAGAAGACTGTATTTTTTACTATGATATCCATTTTCCAGAATTGTGATTAC
AATATGCAAAGAGTCATAAATATGCCATTTACAATAAGGAGGAGGCAAGGCAAATGCATAGATGTACAAATATATGTACAACAGATTTTG
CTTTTTATTTATTTATAATGTAATTTTATAGAATAATTCTGGGATTTGAGAGGATCTAAAACTATTTTTCTGTATAAATATTATTTGCCA
AAAGTTTGTTTATATTCAGAAGTCTGACTATGATGAATAAATCTTAAATGCTTTGTTTAATTAAAAAACAAAAATCACCAATATCCAAGA
CATGAAGATATCAGTTCAACAAATACTGTAGTTAAGAGACTAACTCTCCACTTGTATGGGAACTACATTTCACTCTTGGTTTTCAGGATA
TAACAGCACTTCACCGAAATATTCTTTCAGCCATACCACTGGTAACATTTCTACTAAATCTTTCTGTAACACTTAAAGAATTCCCTCATT
CATTACCTTACAGTGTAAACAGGAGTCTAATTTGTATCAATACTATGTTTTGGTTGTAATATTCAGTTCACTCACCCAATGTACAACCAA

>51408_51408_7_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000350198_MBNL2_chr13_98043576_ENST00000343600_length(amino acids)=74AA_BP=

--------------------------------------------------------------
>51408_51408_8_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000350198_MBNL2_chr13_98043576_ENST00000345429_length(transcript)=2996nt_BP=197nt
CTGGTCTGCGGCTGAGATACACAGAGCGACAGAGACATTTATTGTTATTTGTTTTTTGGTGGCAAAAAGGGAAAATGGCGAACGACTCCC
CTGCAAAAAGTCTGGTGGACATCGACCTCTCCTCCCTGCGGGATCCTGCTGGGATTTTTGAGCTGGTGGAAGTGGTTGGAAATGGCACCT
ATGGACAAGTCTATAAGATAATTCTGAAATAATCAGCAGAAACGGAATGGAATGCCAAGAATCTGCATTGAGAATAACTAAACATTGTTA
CTGTACATACTATCCTGTTTCCTCCTCAATAGAATTGCCACAAACTGCATGCTAAATAAAGATGTAGTTCTTCTGGACAGACCACAACTC
TAAGAAGCTAGTGCTGCTATCTCATATATGAGTATTAAATATGGTATGCTTAGTATATTCCAACCTAAGATAGTTAACTACCTGAGACCA
GCTGTGATGTTTAAAGACATAAAGGATAAAGTTTACTTTTAAAGGGTTTCTAAACATAGTTTCTGTCCTAGGAATATTGTCTTATCTCCA
TAACTATAGCTGATGCAGAAAGTCCAGCCAGTTTACTCATTTCGATTCAGAATATTTCAAATTTAGCAATAAACAATTAGCATTAGTTAA
AAAAGAAACATATTCCAAGGGCAGGTTCGATTCTAGCTCTAATTACTGTCATGTCATTTACCCACTGGATCAAAGGGTATGTTTCACTTC
TTGACAATATAAATGCTGCAGCAAAGATGAGAGGTGAAGTAAAACCGATACCTGTCCTGCAGGTCTAAAATTTGAATGGAAATTCAAGCA
CAAGTACTGGGGACACATCAAAGTGTGGTGTTTGGTTTGCCTGGAGATGCCACGTTGAATCATGTGATTCTAGATTAACATTAAATAGAT
TGAAAAAGAAACTTTGCACGGTATGAGCTTCATACCCCACCAAACAAAGTCTTGAAGGTATTATTTTACAAGTATATTTTTAAAGTTGTT
TTATAAGAGAGACTTTGTAGAAGTGCCTAGATTTTGCCAGACTTCATCCAGCTTGACAAGATTGAGAGGCCCATGCCAACAGTCTAATCT
AAGAGATTAGTCTTTCAAACTCACCATCCAGTTGCCTGTTACAGAATAACTCTTCTTAACTAAAAACCTAGTCAAACAAGGAAGCTGTAG
GTGAGGAGATCTGTATAATATTCTAATTTAAGTAAGTTTGAGTTTAGTCACTGCAAATTTGACTGTGACTTTAATCTAAATTACTATGTA
AACAAAAAGTAGATAGTTTCACTTTTTAAAAAATCCATTACTGTTTTGCATTTCAAAAGTTGGATTAAAGGGTTGTAACTGACTACAGCA
TGGAAAAAAATAGTTCTTTTAATTCTTTCACCTTAAAGCATATTTTATGTCTCAAAAGTATAAAAAACTTTAATACAAGTACATACATAT
TATATATACACATACATATATATACTATATATGGATGAAACATATTTTAATGTTGTTTACTTTTTTAAATACTTGGTTGATCTTCAAGGT
AATAGCGATACAATTAAATTTTGTTCAGAAAGTTTGTTTTAAAGTTTATTTTAAGCACTATCGTACCAAATATTTCATATTTCACATTTT
ATATGTTGCACATAGCCTATACAGTACCTACATAGTTTTTAAATTATTGTTTAAAAAACAAAACAGCTGTTATAAATGAATATTATGTGT
AATTGTTTCAAACATCCATTTTCTTTGTGAACATATTAGTGATTGAAGTATTTTGACTTTTGAGATTGAATGTAAAATATTTTAAATTTG
GGATCATCGCCTGTTCTGAAAACTAGATGCACCAACCGTATCATTATTTGTTTGAGGAAAAAAAGAAATCTGCATTTTAATTCATGTTGG
TCAAAGTCGAATTACTATCTATTTATCTTATATCGTAGATCTGATAACCCTATCTAAAAGAAAGTCACACGCTAAATGTATTCTTACATA
GTGCTTGTATCGTTGCATTTGTTTTAATTTGTGGAAAAGTATTGTATCTAACTTGTATTACTTTGGTAGTTTCATCTTTATGTATTATTG
ATATTTGTAATTTTCTCAACTATAACAATGTAGTTACGCTACAACTTGCCTAAAACATTCAAACTTGTTTTCTTTTTTCTGTTTTTTTCT
TTGTTAATTCATTTAAACTCATTGAAAACATAGTATACATTACTAAAAGGTAAATTATGGGAATCACTGAAATATTTTTGTAGATTAATT
GTTGTAACATTGTCTTTCTTTTTTTTCTTTTGTTTCATGATTTTGATTTTTAAAATTATTAGCACACAACTATTTTCAGCCCTTTAATAA
TGGAGCATCAAAAACATCACCTGTAACCCCAAGCAAATATAGAAGACTGTATTTTTTACTATGATATCCATTTTCCAGAATTGTGATTAC
AATATGCAAAGAGTCATAAATATGCCATTTACAATAAGGAGGAGGCAAGGCAAATGCATAGATGTACAAATATATGTACAACAGATTTTG
CTTTTTATTTATTTATAATGTAATTTTATAGAATAATTCTGGGATTTGAGAGGATCTAAAACTATTTTTCTGTATAAATATTATTTGCCA
AAAGTTTGTTTATATTCAGAAGTCTGACTATGATGAATAAATCTTAAATGCTTTGTTTAATTAAAAAACAAAAATCACCAATATCCAAGA
CATGAAGATATCAGTTCAACAAATACTGTAGTTAAGAGACTAACTCTCCACTTGTATGGGAACTACATTTCACTCTTGGTTTTCAGGATA
TAACAGCACTTCACCGAAATATTCTTTCAGCCATACCACTGGTAACATTTCTACTAAATCTTTCTGTAACACTTAAAGAATTCCCTCATT
CATTACCTTACAGTGTAAACAGGAGTCTAATTTGTATCAATACTATGTTTTGGTTGTAATATTCAGTTCACTCACCCAATGTACAACCAA

>51408_51408_8_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000350198_MBNL2_chr13_98043576_ENST00000345429_length(amino acids)=74AA_BP=

--------------------------------------------------------------
>51408_51408_9_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000413150_MBNL2_chr13_98043576_ENST00000343600_length(transcript)=2976nt_BP=178nt
CACAGAGCGACAGAGACATTTATTGTTATTTGTTTTTTGGTGGCAAAAAGGGAAAATGGCGAACGACTCCCCTGCAAAAAGTCTGGTGGA
CATCGACCTCTCCTCCCTGCGGGATCCTGCTGGGATTTTTGAGCTGGTGGAAGTGGTTGGAAATGGCACCTATGGACAAGTCTATAAGAT
AATTCTGAAATAATCAGCAGAAACGGAATGGAATGCCAAGAATCTGCATTGAGAATAACTAAACATTGTTACTGTACATACTATCCTGTT
TCCTCCTCAATAGAATTGCCACAAACTGCATGCTAAATAAAGATGTAGTTCTTCTGGACAGACCACAACTCTAAGAAGCTAGTGCTGCTA
TCTCATATATGAGTATTAAATATGGTATGCTTAGTATATTCCAACCTAAGATAGTTAACTACCTGAGACCAGCTGTGATGTTTAAAGACA
TAAAGGATAAAGTTTACTTTTAAAGGGTTTCTAAACATAGTTTCTGTCCTAGGAATATTGTCTTATCTCCATAACTATAGCTGATGCAGA
AAGTCCAGCCAGTTTACTCATTTCGATTCAGAATATTTCAAATTTAGCAATAAACAATTAGCATTAGTTAAAAAAGAAACATATTCCAAG
GGCAGGTTCGATTCTAGCTCTAATTACTGTCATGTCATTTACCCACTGGATCAAAGGGTATGTTTCACTTCTTGACAATATAAATGCTGC
AGCAAAGATGAGAGGTGAAGTAAAACCGATACCTGTCCTGCAGGTCTAAAATTTGAATGGAAATTCAAGCACAAGTACTGGGGACACATC
AAAGTGTGGTGTTTGGTTTGCCTGGAGATGCCACGTTGAATCATGTGATTCTAGATTAACATTAAATAGATTGAAAAAGAAACTTTGCAC
GGTATGAGCTTCATACCCCACCAAACAAAGTCTTGAAGGTATTATTTTACAAGTATATTTTTAAAGTTGTTTTATAAGAGAGACTTTGTA
GAAGTGCCTAGATTTTGCCAGACTTCATCCAGCTTGACAAGATTGAGAGGCCCATGCCAACAGTCTAATCTAAGAGATTAGTCTTTCAAA
CTCACCATCCAGTTGCCTGTTACAGAATAACTCTTCTTAACTAAAAACCTAGTCAAACAAGGAAGCTGTAGGTGAGGAGATCTGTATAAT
ATTCTAATTTAAGTAAGTTTGAGTTTAGTCACTGCAAATTTGACTGTGACTTTAATCTAAATTACTATGTAAACAAAAAGTAGATAGTTT
CACTTTTTAAAAAATCCATTACTGTTTTGCATTTCAAAAGTTGGATTAAAGGGTTGTAACTGACTACAGCATGGAAAAAAATAGTTCTTT
TAATTCTTTCACCTTAAAGCATATTTTATGTCTCAAAAGTATAAAAAACTTTAATACAAGTACATACATATTATATATACACATACATAT
ATATACTATATATGGATGAAACATATTTTAATGTTGTTTACTTTTTTAAATACTTGGTTGATCTTCAAGGTAATAGCGATACAATTAAAT
TTTGTTCAGAAAGTTTGTTTTAAAGTTTATTTTAAGCACTATCGTACCAAATATTTCATATTTCACATTTTATATGTTGCACATAGCCTA
TACAGTACCTACATAGTTTTTAAATTATTGTTTAAAAAACAAAACAGCTGTTATAAATGAATATTATGTGTAATTGTTTCAAACATCCAT
TTTCTTTGTGAACATATTAGTGATTGAAGTATTTTGACTTTTGAGATTGAATGTAAAATATTTTAAATTTGGGATCATCGCCTGTTCTGA
AAACTAGATGCACCAACCGTATCATTATTTGTTTGAGGAAAAAAAGAAATCTGCATTTTAATTCATGTTGGTCAAAGTCGAATTACTATC
TATTTATCTTATATCGTAGATCTGATAACCCTATCTAAAAGAAAGTCACACGCTAAATGTATTCTTACATAGTGCTTGTATCGTTGCATT
TGTTTTAATTTGTGGAAAAGTATTGTATCTAACTTGTATTACTTTGGTAGTTTCATCTTTATGTATTATTGATATTTGTAATTTTCTCAA
CTATAACAATGTAGTTACGCTACAACTTGCCTAAAACATTCAAACTTGTTTTCTTTTTTCTGTTTTTTTCTTTGTTAATTCATTTAAACT
CATTGAAAACATAGTATACATTACTAAAAGGTAAATTATGGGAATCACTGAAATATTTTTGTAGATTAATTGTTGTAACATTGTCTTTCT
TTTTTTTCTTTTGTTTCATGATTTTGATTTTTAAAATTATTAGCACACAACTATTTTCAGCCCTTTAATAATGGAGCATCAAAAACATCA
CCTGTAACCCCAAGCAAATATAGAAGACTGTATTTTTTACTATGATATCCATTTTCCAGAATTGTGATTACAATATGCAAAGAGTCATAA
ATATGCCATTTACAATAAGGAGGAGGCAAGGCAAATGCATAGATGTACAAATATATGTACAACAGATTTTGCTTTTTATTTATTTATAAT
GTAATTTTATAGAATAATTCTGGGATTTGAGAGGATCTAAAACTATTTTTCTGTATAAATATTATTTGCCAAAAGTTTGTTTATATTCAG
AAGTCTGACTATGATGAATAAATCTTAAATGCTTTGTTTAATTAAAAAACAAAAATCACCAATATCCAAGACATGAAGATATCAGTTCAA
CAAATACTGTAGTTAAGAGACTAACTCTCCACTTGTATGGGAACTACATTTCACTCTTGGTTTTCAGGATATAACAGCACTTCACCGAAA
TATTCTTTCAGCCATACCACTGGTAACATTTCTACTAAATCTTTCTGTAACACTTAAAGAATTCCCTCATTCATTACCTTACAGTGTAAA
CAGGAGTCTAATTTGTATCAATACTATGTTTTGGTTGTAATATTCAGTTCACTCACCCAATGTACAACCAATGAAATAAAAGAAGCATTT

>51408_51408_9_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000413150_MBNL2_chr13_98043576_ENST00000343600_length(amino acids)=74AA_BP=

--------------------------------------------------------------
>51408_51408_10_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000413150_MBNL2_chr13_98043576_ENST00000345429_length(transcript)=2977nt_BP=178nt
CACAGAGCGACAGAGACATTTATTGTTATTTGTTTTTTGGTGGCAAAAAGGGAAAATGGCGAACGACTCCCCTGCAAAAAGTCTGGTGGA
CATCGACCTCTCCTCCCTGCGGGATCCTGCTGGGATTTTTGAGCTGGTGGAAGTGGTTGGAAATGGCACCTATGGACAAGTCTATAAGAT
AATTCTGAAATAATCAGCAGAAACGGAATGGAATGCCAAGAATCTGCATTGAGAATAACTAAACATTGTTACTGTACATACTATCCTGTT
TCCTCCTCAATAGAATTGCCACAAACTGCATGCTAAATAAAGATGTAGTTCTTCTGGACAGACCACAACTCTAAGAAGCTAGTGCTGCTA
TCTCATATATGAGTATTAAATATGGTATGCTTAGTATATTCCAACCTAAGATAGTTAACTACCTGAGACCAGCTGTGATGTTTAAAGACA
TAAAGGATAAAGTTTACTTTTAAAGGGTTTCTAAACATAGTTTCTGTCCTAGGAATATTGTCTTATCTCCATAACTATAGCTGATGCAGA
AAGTCCAGCCAGTTTACTCATTTCGATTCAGAATATTTCAAATTTAGCAATAAACAATTAGCATTAGTTAAAAAAGAAACATATTCCAAG
GGCAGGTTCGATTCTAGCTCTAATTACTGTCATGTCATTTACCCACTGGATCAAAGGGTATGTTTCACTTCTTGACAATATAAATGCTGC
AGCAAAGATGAGAGGTGAAGTAAAACCGATACCTGTCCTGCAGGTCTAAAATTTGAATGGAAATTCAAGCACAAGTACTGGGGACACATC
AAAGTGTGGTGTTTGGTTTGCCTGGAGATGCCACGTTGAATCATGTGATTCTAGATTAACATTAAATAGATTGAAAAAGAAACTTTGCAC
GGTATGAGCTTCATACCCCACCAAACAAAGTCTTGAAGGTATTATTTTACAAGTATATTTTTAAAGTTGTTTTATAAGAGAGACTTTGTA
GAAGTGCCTAGATTTTGCCAGACTTCATCCAGCTTGACAAGATTGAGAGGCCCATGCCAACAGTCTAATCTAAGAGATTAGTCTTTCAAA
CTCACCATCCAGTTGCCTGTTACAGAATAACTCTTCTTAACTAAAAACCTAGTCAAACAAGGAAGCTGTAGGTGAGGAGATCTGTATAAT
ATTCTAATTTAAGTAAGTTTGAGTTTAGTCACTGCAAATTTGACTGTGACTTTAATCTAAATTACTATGTAAACAAAAAGTAGATAGTTT
CACTTTTTAAAAAATCCATTACTGTTTTGCATTTCAAAAGTTGGATTAAAGGGTTGTAACTGACTACAGCATGGAAAAAAATAGTTCTTT
TAATTCTTTCACCTTAAAGCATATTTTATGTCTCAAAAGTATAAAAAACTTTAATACAAGTACATACATATTATATATACACATACATAT
ATATACTATATATGGATGAAACATATTTTAATGTTGTTTACTTTTTTAAATACTTGGTTGATCTTCAAGGTAATAGCGATACAATTAAAT
TTTGTTCAGAAAGTTTGTTTTAAAGTTTATTTTAAGCACTATCGTACCAAATATTTCATATTTCACATTTTATATGTTGCACATAGCCTA
TACAGTACCTACATAGTTTTTAAATTATTGTTTAAAAAACAAAACAGCTGTTATAAATGAATATTATGTGTAATTGTTTCAAACATCCAT
TTTCTTTGTGAACATATTAGTGATTGAAGTATTTTGACTTTTGAGATTGAATGTAAAATATTTTAAATTTGGGATCATCGCCTGTTCTGA
AAACTAGATGCACCAACCGTATCATTATTTGTTTGAGGAAAAAAAGAAATCTGCATTTTAATTCATGTTGGTCAAAGTCGAATTACTATC
TATTTATCTTATATCGTAGATCTGATAACCCTATCTAAAAGAAAGTCACACGCTAAATGTATTCTTACATAGTGCTTGTATCGTTGCATT
TGTTTTAATTTGTGGAAAAGTATTGTATCTAACTTGTATTACTTTGGTAGTTTCATCTTTATGTATTATTGATATTTGTAATTTTCTCAA
CTATAACAATGTAGTTACGCTACAACTTGCCTAAAACATTCAAACTTGTTTTCTTTTTTCTGTTTTTTTCTTTGTTAATTCATTTAAACT
CATTGAAAACATAGTATACATTACTAAAAGGTAAATTATGGGAATCACTGAAATATTTTTGTAGATTAATTGTTGTAACATTGTCTTTCT
TTTTTTTCTTTTGTTTCATGATTTTGATTTTTAAAATTATTAGCACACAACTATTTTCAGCCCTTTAATAATGGAGCATCAAAAACATCA
CCTGTAACCCCAAGCAAATATAGAAGACTGTATTTTTTACTATGATATCCATTTTCCAGAATTGTGATTACAATATGCAAAGAGTCATAA
ATATGCCATTTACAATAAGGAGGAGGCAAGGCAAATGCATAGATGTACAAATATATGTACAACAGATTTTGCTTTTTATTTATTTATAAT
GTAATTTTATAGAATAATTCTGGGATTTGAGAGGATCTAAAACTATTTTTCTGTATAAATATTATTTGCCAAAAGTTTGTTTATATTCAG
AAGTCTGACTATGATGAATAAATCTTAAATGCTTTGTTTAATTAAAAAACAAAAATCACCAATATCCAAGACATGAAGATATCAGTTCAA
CAAATACTGTAGTTAAGAGACTAACTCTCCACTTGTATGGGAACTACATTTCACTCTTGGTTTTCAGGATATAACAGCACTTCACCGAAA
TATTCTTTCAGCCATACCACTGGTAACATTTCTACTAAATCTTTCTGTAACACTTAAAGAATTCCCTCATTCATTACCTTACAGTGTAAA
CAGGAGTCTAATTTGTATCAATACTATGTTTTGGTTGTAATATTCAGTTCACTCACCCAATGTACAACCAATGAAATAAAAGAAGCATTT

>51408_51408_10_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000413150_MBNL2_chr13_98043576_ENST00000345429_length(amino acids)=74AA_BP=

--------------------------------------------------------------
>51408_51408_11_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000425019_MBNL2_chr13_98043576_ENST00000343600_length(transcript)=3258nt_BP=460nt
GGGCCCGTCCTCGAGGCGCGCGGCGCGGGGCGCGGGCGCCGGGGCCTGAGGCGGCGGGCGACGCCCGGGGGCCTGACGGCCGGCCCCGCG
CCATGGTGTGAGCGCCGCCGCCCGTGCACGCTCCGTCCGCCCTCCGCGCGGCCCGGCCGGCAGAGAGCCCCGAGCGGCCCGAGAGCGCAG
CCGAGCCCGCCGCCGCCGCCCGCGGCCCCGCGAGGAGAGTACCGGGCCGGCTCGGCTGCCGCGCGAGGAGCGCGGTCGGCGGCCTGGTCT
GCGGCTGAGATACACAGAGCGACAGAGACATTTATTGTTATTTGTTTTTTGGTGGCAAAAAGGGAAAATGGCGAACGACTCCCCTGCAAA
AAGTCTGGTGGACATCGACCTCTCCTCCCTGCGGGATCCTGCTGGGATTTTTGAGCTGGTGGAAGTGGTTGGAAATGGCACCTATGGACA
AGTCTATAAGATAATTCTGAAATAATCAGCAGAAACGGAATGGAATGCCAAGAATCTGCATTGAGAATAACTAAACATTGTTACTGTACA
TACTATCCTGTTTCCTCCTCAATAGAATTGCCACAAACTGCATGCTAAATAAAGATGTAGTTCTTCTGGACAGACCACAACTCTAAGAAG
CTAGTGCTGCTATCTCATATATGAGTATTAAATATGGTATGCTTAGTATATTCCAACCTAAGATAGTTAACTACCTGAGACCAGCTGTGA
TGTTTAAAGACATAAAGGATAAAGTTTACTTTTAAAGGGTTTCTAAACATAGTTTCTGTCCTAGGAATATTGTCTTATCTCCATAACTAT
AGCTGATGCAGAAAGTCCAGCCAGTTTACTCATTTCGATTCAGAATATTTCAAATTTAGCAATAAACAATTAGCATTAGTTAAAAAAGAA
ACATATTCCAAGGGCAGGTTCGATTCTAGCTCTAATTACTGTCATGTCATTTACCCACTGGATCAAAGGGTATGTTTCACTTCTTGACAA
TATAAATGCTGCAGCAAAGATGAGAGGTGAAGTAAAACCGATACCTGTCCTGCAGGTCTAAAATTTGAATGGAAATTCAAGCACAAGTAC
TGGGGACACATCAAAGTGTGGTGTTTGGTTTGCCTGGAGATGCCACGTTGAATCATGTGATTCTAGATTAACATTAAATAGATTGAAAAA
GAAACTTTGCACGGTATGAGCTTCATACCCCACCAAACAAAGTCTTGAAGGTATTATTTTACAAGTATATTTTTAAAGTTGTTTTATAAG
AGAGACTTTGTAGAAGTGCCTAGATTTTGCCAGACTTCATCCAGCTTGACAAGATTGAGAGGCCCATGCCAACAGTCTAATCTAAGAGAT
TAGTCTTTCAAACTCACCATCCAGTTGCCTGTTACAGAATAACTCTTCTTAACTAAAAACCTAGTCAAACAAGGAAGCTGTAGGTGAGGA
GATCTGTATAATATTCTAATTTAAGTAAGTTTGAGTTTAGTCACTGCAAATTTGACTGTGACTTTAATCTAAATTACTATGTAAACAAAA
AGTAGATAGTTTCACTTTTTAAAAAATCCATTACTGTTTTGCATTTCAAAAGTTGGATTAAAGGGTTGTAACTGACTACAGCATGGAAAA
AAATAGTTCTTTTAATTCTTTCACCTTAAAGCATATTTTATGTCTCAAAAGTATAAAAAACTTTAATACAAGTACATACATATTATATAT
ACACATACATATATATACTATATATGGATGAAACATATTTTAATGTTGTTTACTTTTTTAAATACTTGGTTGATCTTCAAGGTAATAGCG
ATACAATTAAATTTTGTTCAGAAAGTTTGTTTTAAAGTTTATTTTAAGCACTATCGTACCAAATATTTCATATTTCACATTTTATATGTT
GCACATAGCCTATACAGTACCTACATAGTTTTTAAATTATTGTTTAAAAAACAAAACAGCTGTTATAAATGAATATTATGTGTAATTGTT
TCAAACATCCATTTTCTTTGTGAACATATTAGTGATTGAAGTATTTTGACTTTTGAGATTGAATGTAAAATATTTTAAATTTGGGATCAT
CGCCTGTTCTGAAAACTAGATGCACCAACCGTATCATTATTTGTTTGAGGAAAAAAAGAAATCTGCATTTTAATTCATGTTGGTCAAAGT
CGAATTACTATCTATTTATCTTATATCGTAGATCTGATAACCCTATCTAAAAGAAAGTCACACGCTAAATGTATTCTTACATAGTGCTTG
TATCGTTGCATTTGTTTTAATTTGTGGAAAAGTATTGTATCTAACTTGTATTACTTTGGTAGTTTCATCTTTATGTATTATTGATATTTG
TAATTTTCTCAACTATAACAATGTAGTTACGCTACAACTTGCCTAAAACATTCAAACTTGTTTTCTTTTTTCTGTTTTTTTCTTTGTTAA
TTCATTTAAACTCATTGAAAACATAGTATACATTACTAAAAGGTAAATTATGGGAATCACTGAAATATTTTTGTAGATTAATTGTTGTAA
CATTGTCTTTCTTTTTTTTCTTTTGTTTCATGATTTTGATTTTTAAAATTATTAGCACACAACTATTTTCAGCCCTTTAATAATGGAGCA
TCAAAAACATCACCTGTAACCCCAAGCAAATATAGAAGACTGTATTTTTTACTATGATATCCATTTTCCAGAATTGTGATTACAATATGC
AAAGAGTCATAAATATGCCATTTACAATAAGGAGGAGGCAAGGCAAATGCATAGATGTACAAATATATGTACAACAGATTTTGCTTTTTA
TTTATTTATAATGTAATTTTATAGAATAATTCTGGGATTTGAGAGGATCTAAAACTATTTTTCTGTATAAATATTATTTGCCAAAAGTTT
GTTTATATTCAGAAGTCTGACTATGATGAATAAATCTTAAATGCTTTGTTTAATTAAAAAACAAAAATCACCAATATCCAAGACATGAAG
ATATCAGTTCAACAAATACTGTAGTTAAGAGACTAACTCTCCACTTGTATGGGAACTACATTTCACTCTTGGTTTTCAGGATATAACAGC
ACTTCACCGAAATATTCTTTCAGCCATACCACTGGTAACATTTCTACTAAATCTTTCTGTAACACTTAAAGAATTCCCTCATTCATTACC
TTACAGTGTAAACAGGAGTCTAATTTGTATCAATACTATGTTTTGGTTGTAATATTCAGTTCACTCACCCAATGTACAACCAATGAAATA

>51408_51408_11_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000425019_MBNL2_chr13_98043576_ENST00000343600_length(amino acids)=160AA_BP=
MLIISELSYRLVHRCHFQPLPPAQKSQQDPAGRRGRCPPDFLQGSRSPFSLFATKKQITINVSVALCISAADQAADRAPRAAAEPARYSP

--------------------------------------------------------------
>51408_51408_12_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000425019_MBNL2_chr13_98043576_ENST00000345429_length(transcript)=3259nt_BP=460nt
GGGCCCGTCCTCGAGGCGCGCGGCGCGGGGCGCGGGCGCCGGGGCCTGAGGCGGCGGGCGACGCCCGGGGGCCTGACGGCCGGCCCCGCG
CCATGGTGTGAGCGCCGCCGCCCGTGCACGCTCCGTCCGCCCTCCGCGCGGCCCGGCCGGCAGAGAGCCCCGAGCGGCCCGAGAGCGCAG
CCGAGCCCGCCGCCGCCGCCCGCGGCCCCGCGAGGAGAGTACCGGGCCGGCTCGGCTGCCGCGCGAGGAGCGCGGTCGGCGGCCTGGTCT
GCGGCTGAGATACACAGAGCGACAGAGACATTTATTGTTATTTGTTTTTTGGTGGCAAAAAGGGAAAATGGCGAACGACTCCCCTGCAAA
AAGTCTGGTGGACATCGACCTCTCCTCCCTGCGGGATCCTGCTGGGATTTTTGAGCTGGTGGAAGTGGTTGGAAATGGCACCTATGGACA
AGTCTATAAGATAATTCTGAAATAATCAGCAGAAACGGAATGGAATGCCAAGAATCTGCATTGAGAATAACTAAACATTGTTACTGTACA
TACTATCCTGTTTCCTCCTCAATAGAATTGCCACAAACTGCATGCTAAATAAAGATGTAGTTCTTCTGGACAGACCACAACTCTAAGAAG
CTAGTGCTGCTATCTCATATATGAGTATTAAATATGGTATGCTTAGTATATTCCAACCTAAGATAGTTAACTACCTGAGACCAGCTGTGA
TGTTTAAAGACATAAAGGATAAAGTTTACTTTTAAAGGGTTTCTAAACATAGTTTCTGTCCTAGGAATATTGTCTTATCTCCATAACTAT
AGCTGATGCAGAAAGTCCAGCCAGTTTACTCATTTCGATTCAGAATATTTCAAATTTAGCAATAAACAATTAGCATTAGTTAAAAAAGAA
ACATATTCCAAGGGCAGGTTCGATTCTAGCTCTAATTACTGTCATGTCATTTACCCACTGGATCAAAGGGTATGTTTCACTTCTTGACAA
TATAAATGCTGCAGCAAAGATGAGAGGTGAAGTAAAACCGATACCTGTCCTGCAGGTCTAAAATTTGAATGGAAATTCAAGCACAAGTAC
TGGGGACACATCAAAGTGTGGTGTTTGGTTTGCCTGGAGATGCCACGTTGAATCATGTGATTCTAGATTAACATTAAATAGATTGAAAAA
GAAACTTTGCACGGTATGAGCTTCATACCCCACCAAACAAAGTCTTGAAGGTATTATTTTACAAGTATATTTTTAAAGTTGTTTTATAAG
AGAGACTTTGTAGAAGTGCCTAGATTTTGCCAGACTTCATCCAGCTTGACAAGATTGAGAGGCCCATGCCAACAGTCTAATCTAAGAGAT
TAGTCTTTCAAACTCACCATCCAGTTGCCTGTTACAGAATAACTCTTCTTAACTAAAAACCTAGTCAAACAAGGAAGCTGTAGGTGAGGA
GATCTGTATAATATTCTAATTTAAGTAAGTTTGAGTTTAGTCACTGCAAATTTGACTGTGACTTTAATCTAAATTACTATGTAAACAAAA
AGTAGATAGTTTCACTTTTTAAAAAATCCATTACTGTTTTGCATTTCAAAAGTTGGATTAAAGGGTTGTAACTGACTACAGCATGGAAAA
AAATAGTTCTTTTAATTCTTTCACCTTAAAGCATATTTTATGTCTCAAAAGTATAAAAAACTTTAATACAAGTACATACATATTATATAT
ACACATACATATATATACTATATATGGATGAAACATATTTTAATGTTGTTTACTTTTTTAAATACTTGGTTGATCTTCAAGGTAATAGCG
ATACAATTAAATTTTGTTCAGAAAGTTTGTTTTAAAGTTTATTTTAAGCACTATCGTACCAAATATTTCATATTTCACATTTTATATGTT
GCACATAGCCTATACAGTACCTACATAGTTTTTAAATTATTGTTTAAAAAACAAAACAGCTGTTATAAATGAATATTATGTGTAATTGTT
TCAAACATCCATTTTCTTTGTGAACATATTAGTGATTGAAGTATTTTGACTTTTGAGATTGAATGTAAAATATTTTAAATTTGGGATCAT
CGCCTGTTCTGAAAACTAGATGCACCAACCGTATCATTATTTGTTTGAGGAAAAAAAGAAATCTGCATTTTAATTCATGTTGGTCAAAGT
CGAATTACTATCTATTTATCTTATATCGTAGATCTGATAACCCTATCTAAAAGAAAGTCACACGCTAAATGTATTCTTACATAGTGCTTG
TATCGTTGCATTTGTTTTAATTTGTGGAAAAGTATTGTATCTAACTTGTATTACTTTGGTAGTTTCATCTTTATGTATTATTGATATTTG
TAATTTTCTCAACTATAACAATGTAGTTACGCTACAACTTGCCTAAAACATTCAAACTTGTTTTCTTTTTTCTGTTTTTTTCTTTGTTAA
TTCATTTAAACTCATTGAAAACATAGTATACATTACTAAAAGGTAAATTATGGGAATCACTGAAATATTTTTGTAGATTAATTGTTGTAA
CATTGTCTTTCTTTTTTTTCTTTTGTTTCATGATTTTGATTTTTAAAATTATTAGCACACAACTATTTTCAGCCCTTTAATAATGGAGCA
TCAAAAACATCACCTGTAACCCCAAGCAAATATAGAAGACTGTATTTTTTACTATGATATCCATTTTCCAGAATTGTGATTACAATATGC
AAAGAGTCATAAATATGCCATTTACAATAAGGAGGAGGCAAGGCAAATGCATAGATGTACAAATATATGTACAACAGATTTTGCTTTTTA
TTTATTTATAATGTAATTTTATAGAATAATTCTGGGATTTGAGAGGATCTAAAACTATTTTTCTGTATAAATATTATTTGCCAAAAGTTT
GTTTATATTCAGAAGTCTGACTATGATGAATAAATCTTAAATGCTTTGTTTAATTAAAAAACAAAAATCACCAATATCCAAGACATGAAG
ATATCAGTTCAACAAATACTGTAGTTAAGAGACTAACTCTCCACTTGTATGGGAACTACATTTCACTCTTGGTTTTCAGGATATAACAGC
ACTTCACCGAAATATTCTTTCAGCCATACCACTGGTAACATTTCTACTAAATCTTTCTGTAACACTTAAAGAATTCCCTCATTCATTACC
TTACAGTGTAAACAGGAGTCTAATTTGTATCAATACTATGTTTTGGTTGTAATATTCAGTTCACTCACCCAATGTACAACCAATGAAATA

>51408_51408_12_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000425019_MBNL2_chr13_98043576_ENST00000345429_length(amino acids)=125AA_BP=
MSTRLFAGESFAIFPFCHQKTNNNKCLCRSVYLSRRPGRRPRSSRGSRAGPVLSSRGRGRRRRARLRSRAARGSLPAGPRGGRTERARAA

--------------------------------------------------------------
>51408_51408_13_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000456652_MBNL2_chr13_98043576_ENST00000343600_length(transcript)=2921nt_BP=123nt
ATGGCGAACGACTCCCCTGCAAAAAGTCTGGTGGACATCGACCTCTCCTCCCTGCGGGATCCTGCTGGGATTTTTGAGCTGGTGGAAGTG
GTTGGAAATGGCACCTATGGACAAGTCTATAAGATAATTCTGAAATAATCAGCAGAAACGGAATGGAATGCCAAGAATCTGCATTGAGAA
TAACTAAACATTGTTACTGTACATACTATCCTGTTTCCTCCTCAATAGAATTGCCACAAACTGCATGCTAAATAAAGATGTAGTTCTTCT
GGACAGACCACAACTCTAAGAAGCTAGTGCTGCTATCTCATATATGAGTATTAAATATGGTATGCTTAGTATATTCCAACCTAAGATAGT
TAACTACCTGAGACCAGCTGTGATGTTTAAAGACATAAAGGATAAAGTTTACTTTTAAAGGGTTTCTAAACATAGTTTCTGTCCTAGGAA
TATTGTCTTATCTCCATAACTATAGCTGATGCAGAAAGTCCAGCCAGTTTACTCATTTCGATTCAGAATATTTCAAATTTAGCAATAAAC
AATTAGCATTAGTTAAAAAAGAAACATATTCCAAGGGCAGGTTCGATTCTAGCTCTAATTACTGTCATGTCATTTACCCACTGGATCAAA
GGGTATGTTTCACTTCTTGACAATATAAATGCTGCAGCAAAGATGAGAGGTGAAGTAAAACCGATACCTGTCCTGCAGGTCTAAAATTTG
AATGGAAATTCAAGCACAAGTACTGGGGACACATCAAAGTGTGGTGTTTGGTTTGCCTGGAGATGCCACGTTGAATCATGTGATTCTAGA
TTAACATTAAATAGATTGAAAAAGAAACTTTGCACGGTATGAGCTTCATACCCCACCAAACAAAGTCTTGAAGGTATTATTTTACAAGTA
TATTTTTAAAGTTGTTTTATAAGAGAGACTTTGTAGAAGTGCCTAGATTTTGCCAGACTTCATCCAGCTTGACAAGATTGAGAGGCCCAT
GCCAACAGTCTAATCTAAGAGATTAGTCTTTCAAACTCACCATCCAGTTGCCTGTTACAGAATAACTCTTCTTAACTAAAAACCTAGTCA
AACAAGGAAGCTGTAGGTGAGGAGATCTGTATAATATTCTAATTTAAGTAAGTTTGAGTTTAGTCACTGCAAATTTGACTGTGACTTTAA
TCTAAATTACTATGTAAACAAAAAGTAGATAGTTTCACTTTTTAAAAAATCCATTACTGTTTTGCATTTCAAAAGTTGGATTAAAGGGTT
GTAACTGACTACAGCATGGAAAAAAATAGTTCTTTTAATTCTTTCACCTTAAAGCATATTTTATGTCTCAAAAGTATAAAAAACTTTAAT
ACAAGTACATACATATTATATATACACATACATATATATACTATATATGGATGAAACATATTTTAATGTTGTTTACTTTTTTAAATACTT
GGTTGATCTTCAAGGTAATAGCGATACAATTAAATTTTGTTCAGAAAGTTTGTTTTAAAGTTTATTTTAAGCACTATCGTACCAAATATT
TCATATTTCACATTTTATATGTTGCACATAGCCTATACAGTACCTACATAGTTTTTAAATTATTGTTTAAAAAACAAAACAGCTGTTATA
AATGAATATTATGTGTAATTGTTTCAAACATCCATTTTCTTTGTGAACATATTAGTGATTGAAGTATTTTGACTTTTGAGATTGAATGTA
AAATATTTTAAATTTGGGATCATCGCCTGTTCTGAAAACTAGATGCACCAACCGTATCATTATTTGTTTGAGGAAAAAAAGAAATCTGCA
TTTTAATTCATGTTGGTCAAAGTCGAATTACTATCTATTTATCTTATATCGTAGATCTGATAACCCTATCTAAAAGAAAGTCACACGCTA
AATGTATTCTTACATAGTGCTTGTATCGTTGCATTTGTTTTAATTTGTGGAAAAGTATTGTATCTAACTTGTATTACTTTGGTAGTTTCA
TCTTTATGTATTATTGATATTTGTAATTTTCTCAACTATAACAATGTAGTTACGCTACAACTTGCCTAAAACATTCAAACTTGTTTTCTT
TTTTCTGTTTTTTTCTTTGTTAATTCATTTAAACTCATTGAAAACATAGTATACATTACTAAAAGGTAAATTATGGGAATCACTGAAATA
TTTTTGTAGATTAATTGTTGTAACATTGTCTTTCTTTTTTTTCTTTTGTTTCATGATTTTGATTTTTAAAATTATTAGCACACAACTATT
TTCAGCCCTTTAATAATGGAGCATCAAAAACATCACCTGTAACCCCAAGCAAATATAGAAGACTGTATTTTTTACTATGATATCCATTTT
CCAGAATTGTGATTACAATATGCAAAGAGTCATAAATATGCCATTTACAATAAGGAGGAGGCAAGGCAAATGCATAGATGTACAAATATA
TGTACAACAGATTTTGCTTTTTATTTATTTATAATGTAATTTTATAGAATAATTCTGGGATTTGAGAGGATCTAAAACTATTTTTCTGTA
TAAATATTATTTGCCAAAAGTTTGTTTATATTCAGAAGTCTGACTATGATGAATAAATCTTAAATGCTTTGTTTAATTAAAAAACAAAAA
TCACCAATATCCAAGACATGAAGATATCAGTTCAACAAATACTGTAGTTAAGAGACTAACTCTCCACTTGTATGGGAACTACATTTCACT
CTTGGTTTTCAGGATATAACAGCACTTCACCGAAATATTCTTTCAGCCATACCACTGGTAACATTTCTACTAAATCTTTCTGTAACACTT
AAAGAATTCCCTCATTCATTACCTTACAGTGTAAACAGGAGTCTAATTTGTATCAATACTATGTTTTGGTTGTAATATTCAGTTCACTCA

>51408_51408_13_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000456652_MBNL2_chr13_98043576_ENST00000343600_length(amino acids)=74AA_BP=

--------------------------------------------------------------
>51408_51408_14_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000456652_MBNL2_chr13_98043576_ENST00000345429_length(transcript)=2922nt_BP=123nt
ATGGCGAACGACTCCCCTGCAAAAAGTCTGGTGGACATCGACCTCTCCTCCCTGCGGGATCCTGCTGGGATTTTTGAGCTGGTGGAAGTG
GTTGGAAATGGCACCTATGGACAAGTCTATAAGATAATTCTGAAATAATCAGCAGAAACGGAATGGAATGCCAAGAATCTGCATTGAGAA
TAACTAAACATTGTTACTGTACATACTATCCTGTTTCCTCCTCAATAGAATTGCCACAAACTGCATGCTAAATAAAGATGTAGTTCTTCT
GGACAGACCACAACTCTAAGAAGCTAGTGCTGCTATCTCATATATGAGTATTAAATATGGTATGCTTAGTATATTCCAACCTAAGATAGT
TAACTACCTGAGACCAGCTGTGATGTTTAAAGACATAAAGGATAAAGTTTACTTTTAAAGGGTTTCTAAACATAGTTTCTGTCCTAGGAA
TATTGTCTTATCTCCATAACTATAGCTGATGCAGAAAGTCCAGCCAGTTTACTCATTTCGATTCAGAATATTTCAAATTTAGCAATAAAC
AATTAGCATTAGTTAAAAAAGAAACATATTCCAAGGGCAGGTTCGATTCTAGCTCTAATTACTGTCATGTCATTTACCCACTGGATCAAA
GGGTATGTTTCACTTCTTGACAATATAAATGCTGCAGCAAAGATGAGAGGTGAAGTAAAACCGATACCTGTCCTGCAGGTCTAAAATTTG
AATGGAAATTCAAGCACAAGTACTGGGGACACATCAAAGTGTGGTGTTTGGTTTGCCTGGAGATGCCACGTTGAATCATGTGATTCTAGA
TTAACATTAAATAGATTGAAAAAGAAACTTTGCACGGTATGAGCTTCATACCCCACCAAACAAAGTCTTGAAGGTATTATTTTACAAGTA
TATTTTTAAAGTTGTTTTATAAGAGAGACTTTGTAGAAGTGCCTAGATTTTGCCAGACTTCATCCAGCTTGACAAGATTGAGAGGCCCAT
GCCAACAGTCTAATCTAAGAGATTAGTCTTTCAAACTCACCATCCAGTTGCCTGTTACAGAATAACTCTTCTTAACTAAAAACCTAGTCA
AACAAGGAAGCTGTAGGTGAGGAGATCTGTATAATATTCTAATTTAAGTAAGTTTGAGTTTAGTCACTGCAAATTTGACTGTGACTTTAA
TCTAAATTACTATGTAAACAAAAAGTAGATAGTTTCACTTTTTAAAAAATCCATTACTGTTTTGCATTTCAAAAGTTGGATTAAAGGGTT
GTAACTGACTACAGCATGGAAAAAAATAGTTCTTTTAATTCTTTCACCTTAAAGCATATTTTATGTCTCAAAAGTATAAAAAACTTTAAT
ACAAGTACATACATATTATATATACACATACATATATATACTATATATGGATGAAACATATTTTAATGTTGTTTACTTTTTTAAATACTT
GGTTGATCTTCAAGGTAATAGCGATACAATTAAATTTTGTTCAGAAAGTTTGTTTTAAAGTTTATTTTAAGCACTATCGTACCAAATATT
TCATATTTCACATTTTATATGTTGCACATAGCCTATACAGTACCTACATAGTTTTTAAATTATTGTTTAAAAAACAAAACAGCTGTTATA
AATGAATATTATGTGTAATTGTTTCAAACATCCATTTTCTTTGTGAACATATTAGTGATTGAAGTATTTTGACTTTTGAGATTGAATGTA
AAATATTTTAAATTTGGGATCATCGCCTGTTCTGAAAACTAGATGCACCAACCGTATCATTATTTGTTTGAGGAAAAAAAGAAATCTGCA
TTTTAATTCATGTTGGTCAAAGTCGAATTACTATCTATTTATCTTATATCGTAGATCTGATAACCCTATCTAAAAGAAAGTCACACGCTA
AATGTATTCTTACATAGTGCTTGTATCGTTGCATTTGTTTTAATTTGTGGAAAAGTATTGTATCTAACTTGTATTACTTTGGTAGTTTCA
TCTTTATGTATTATTGATATTTGTAATTTTCTCAACTATAACAATGTAGTTACGCTACAACTTGCCTAAAACATTCAAACTTGTTTTCTT
TTTTCTGTTTTTTTCTTTGTTAATTCATTTAAACTCATTGAAAACATAGTATACATTACTAAAAGGTAAATTATGGGAATCACTGAAATA
TTTTTGTAGATTAATTGTTGTAACATTGTCTTTCTTTTTTTTCTTTTGTTTCATGATTTTGATTTTTAAAATTATTAGCACACAACTATT
TTCAGCCCTTTAATAATGGAGCATCAAAAACATCACCTGTAACCCCAAGCAAATATAGAAGACTGTATTTTTTACTATGATATCCATTTT
CCAGAATTGTGATTACAATATGCAAAGAGTCATAAATATGCCATTTACAATAAGGAGGAGGCAAGGCAAATGCATAGATGTACAAATATA
TGTACAACAGATTTTGCTTTTTATTTATTTATAATGTAATTTTATAGAATAATTCTGGGATTTGAGAGGATCTAAAACTATTTTTCTGTA
TAAATATTATTTGCCAAAAGTTTGTTTATATTCAGAAGTCTGACTATGATGAATAAATCTTAAATGCTTTGTTTAATTAAAAAACAAAAA
TCACCAATATCCAAGACATGAAGATATCAGTTCAACAAATACTGTAGTTAAGAGACTAACTCTCCACTTGTATGGGAACTACATTTCACT
CTTGGTTTTCAGGATATAACAGCACTTCACCGAAATATTCTTTCAGCCATACCACTGGTAACATTTCTACTAAATCTTTCTGTAACACTT
AAAGAATTCCCTCATTCATTACCTTACAGTGTAAACAGGAGTCTAATTTGTATCAATACTATGTTTTGGTTGTAATATTCAGTTCACTCA

>51408_51408_14_MAP4K4-MBNL2_MAP4K4_chr2_102315000_ENST00000456652_MBNL2_chr13_98043576_ENST00000345429_length(amino acids)=74AA_BP=

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MAP4K4-MBNL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAP4K4-MBNL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAP4K4-MBNL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAP4K4C0024121Lung Neoplasms1CTD_human
HgeneMAP4K4C0242379Malignant neoplasm of lung1CTD_human