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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HOMER1-TMEM214 (FusionGDB2 ID:HG9456TG54867)

Fusion Gene Summary for HOMER1-TMEM214

check button Fusion gene summary
Fusion gene informationFusion gene name: HOMER1-TMEM214
Fusion gene ID: hg9456tg54867
HgeneTgene
Gene symbol

HOMER1

TMEM214

Gene ID

9456

54867

Gene namehomer scaffold protein 1transmembrane protein 214
SynonymsHOMER|HOMER1A|HOMER1B|HOMER1C|SYN47|Ves-1-
Cytomap('HOMER1')('TMEM214')

5q14.1

2p23.3

Type of geneprotein-codingprotein-coding
Descriptionhomer protein homolog 1homer homolog 1homer scaffolding protein 1homer, neuronal immediate early gene, 1homer-1transmembrane protein 214
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000282260, ENST00000334082, 
ENST00000508576, ENST00000535690, 
Fusion gene scores* DoF score7 X 6 X 5=21015 X 15 X 1=225
# samples 817
** MAII scorelog2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/225*10)=-0.404390255079335
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HOMER1 [Title/Abstract] AND TMEM214 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHOMER1(78668720)-TMEM214(27264542), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHOMER1

GO:0051592

response to calcium ion

14505576



check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AEC571513HOMER1chr5

78668720

+TMEM214chr2

27264542

-


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Fusion Gene ORF analysis for HOMER1-TMEM214

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000282260ENST00000238788HOMER1chr5

78668720

+TMEM214chr2

27264542

-
intron-3UTRENST00000282260ENST00000404032HOMER1chr5

78668720

+TMEM214chr2

27264542

-
intron-3UTRENST00000334082ENST00000238788HOMER1chr5

78668720

+TMEM214chr2

27264542

-
intron-3UTRENST00000334082ENST00000404032HOMER1chr5

78668720

+TMEM214chr2

27264542

-
intron-3UTRENST00000508576ENST00000238788HOMER1chr5

78668720

+TMEM214chr2

27264542

-
intron-3UTRENST00000508576ENST00000404032HOMER1chr5

78668720

+TMEM214chr2

27264542

-
intron-3UTRENST00000535690ENST00000238788HOMER1chr5

78668720

+TMEM214chr2

27264542

-
intron-3UTRENST00000535690ENST00000404032HOMER1chr5

78668720

+TMEM214chr2

27264542

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for HOMER1-TMEM214


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for HOMER1-TMEM214


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:78668720/:27264542)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for HOMER1-TMEM214


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HOMER1-TMEM214


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HOMER1-TMEM214


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HOMER1-TMEM214


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHOMER1C0036341Schizophrenia4PSYGENET
HgeneHOMER1C0011570Mental Depression3PSYGENET
HgeneHOMER1C0011581Depressive disorder3PSYGENET
HgeneHOMER1C0009171Cocaine Abuse2CTD_human
HgeneHOMER1C0236736Cocaine-Related Disorders2CTD_human
HgeneHOMER1C0600427Cocaine Dependence2CTD_human
HgeneHOMER1C0013221Drug toxicity1CTD_human
HgeneHOMER1C0013386Dyskinesia, Drug-Induced1CTD_human
HgeneHOMER1C0018524Hallucinations1CTD_human
HgeneHOMER1C0029226Hallucinations, Organic1CTD_human
HgeneHOMER1C0041696Unipolar Depression1PSYGENET
HgeneHOMER1C0041755Adverse reaction to drug1CTD_human
HgeneHOMER1C0233759Hallucinations, Elementary1CTD_human
HgeneHOMER1C0233762Hallucinations, Auditory1CTD_human
HgeneHOMER1C0233763Hallucinations, Visual1CTD_human
HgeneHOMER1C0233765Hallucinations, Olfactory1CTD_human
HgeneHOMER1C0233766Hallucinations, Gustatory1CTD_human
HgeneHOMER1C0233767Hallucinations, Tactile1CTD_human
HgeneHOMER1C0233773Hallucinations, Hypnagogic1CTD_human
HgeneHOMER1C0233774Hallucinations, Somatic1CTD_human
HgeneHOMER1C0233775Hallucinations, Mood Congruent1CTD_human
HgeneHOMER1C0233776Hallucinations, Mood Incongruent1CTD_human
HgeneHOMER1C0235153Hallucinations, Sensory1CTD_human
HgeneHOMER1C0424068Verbal auditory hallucinations1CTD_human
HgeneHOMER1C0424071Hallucinations, Visual, Unformed1CTD_human
HgeneHOMER1C0424072Hallucinations, Visual, Formed1CTD_human
HgeneHOMER1C0424082Hallucinations, Hypnapompic1CTD_human
HgeneHOMER1C0424083Hallucinations, Dissociative1CTD_human
HgeneHOMER1C0544668Hallucinations, Kinesthetic1CTD_human
HgeneHOMER1C0563608Hallucinations, Formed, of People1CTD_human
HgeneHOMER1C0563661Hallucinations, Reflex1CTD_human
HgeneHOMER1C0751088Dyskinesia, Medication-Induced1CTD_human
HgeneHOMER1C0751175Hallucination of Body Sensation1CTD_human
HgeneHOMER1C0751176Hallucinations, Internal Body Sensation1CTD_human
HgeneHOMER1C1269683Major Depressive Disorder1PSYGENET